-- dump date   	20140618_191208
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
339671000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
339671000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
339671000003	Bacterial dnaA protein; Region: Bac_DnaA; pfam00308
339671000004	Walker B motif; other site
339671000005	arginine finger; other site
339671000006	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
339671000007	DnaA box-binding interface [nucleotide binding]; other site
339671000008	DNA polymerase III subunit beta; Validated; Region: PRK05643
339671000009	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
339671000010	putative DNA binding surface [nucleotide binding]; other site
339671000011	dimer interface [polypeptide binding]; other site
339671000012	beta-clamp/clamp loader binding surface; other site
339671000013	beta-clamp/translesion DNA polymerase binding surface; other site
339671000014	recF protein; Region: recf; TIGR00611
339671000015	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671000016	Walker A/P-loop; other site
339671000017	ATP binding site [chemical binding]; other site
339671000018	Q-loop/lid; other site
339671000019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671000020	ABC transporter signature motif; other site
339671000021	Walker B; other site
339671000022	D-loop; other site
339671000023	H-loop/switch region; other site
339671000024	D-lactate dehydrogenase; Provisional; Region: PRK11183
339671000025	FAD binding domain; Region: FAD_binding_4; pfam01565
339671000026	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
339671000027	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
339671000028	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
339671000029	TrkA-N domain; Region: TrkA_N; pfam02254
339671000030	Methyltransferase domain; Region: Methyltransf_31; pfam13847
339671000031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671000032	S-adenosylmethionine binding site [chemical binding]; other site
339671000033	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
339671000034	intersubunit interface [polypeptide binding]; other site
339671000035	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
339671000036	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
339671000037	ligand binding site [chemical binding]; other site
339671000038	flexible hinge region; other site
339671000039	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
339671000040	putative switch regulator; other site
339671000041	non-specific DNA interactions [nucleotide binding]; other site
339671000042	DNA binding site [nucleotide binding]
339671000043	sequence specific DNA binding site [nucleotide binding]; other site
339671000044	putative cAMP binding site [chemical binding]; other site
339671000045	hypothetical protein; Provisional; Region: PRK04966
339671000046	division inhibitor protein; Provisional; Region: slmA; PRK09480
339671000047	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
339671000048	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
339671000049	trimer interface [polypeptide binding]; other site
339671000050	active site
339671000051	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
339671000052	Flavoprotein; Region: Flavoprotein; pfam02441
339671000053	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
339671000054	hypothetical protein; Reviewed; Region: PRK00024
339671000055	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
339671000056	MPN+ (JAMM) motif; other site
339671000057	Zinc-binding site [ion binding]; other site
339671000058	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
339671000059	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
339671000060	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
339671000061	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
339671000062	DNA binding site [nucleotide binding]
339671000063	catalytic residue [active]
339671000064	H2TH interface [polypeptide binding]; other site
339671000065	putative catalytic residues [active]
339671000066	turnover-facilitating residue; other site
339671000067	intercalation triad [nucleotide binding]; other site
339671000068	8OG recognition residue [nucleotide binding]; other site
339671000069	putative reading head residues; other site
339671000070	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
339671000071	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
339671000072	dihydrodipicolinate synthase; Region: dapA; TIGR00674
339671000073	dimer interface [polypeptide binding]; other site
339671000074	active site
339671000075	catalytic residue [active]
339671000076	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
339671000077	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
339671000078	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
339671000079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671000080	S-adenosylmethionine binding site [chemical binding]; other site
339671000081	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
339671000082	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
339671000083	transmembrane helices; other site
339671000084	DNA polymerase I; Provisional; Region: PRK05755
339671000085	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
339671000086	active site
339671000087	metal binding site 1 [ion binding]; metal-binding site
339671000088	putative 5' ssDNA interaction site; other site
339671000089	metal binding site 3; metal-binding site
339671000090	metal binding site 2 [ion binding]; metal-binding site
339671000091	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
339671000092	putative DNA binding site [nucleotide binding]; other site
339671000093	putative metal binding site [ion binding]; other site
339671000094	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
339671000095	active site
339671000096	catalytic site [active]
339671000097	substrate binding site [chemical binding]; other site
339671000098	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
339671000099	active site
339671000100	DNA binding site [nucleotide binding]
339671000101	catalytic site [active]
339671000102	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
339671000103	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
339671000104	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
339671000105	putative transporter; Validated; Region: PRK03818
339671000106	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
339671000107	TrkA-C domain; Region: TrkA_C; pfam02080
339671000108	TrkA-C domain; Region: TrkA_C; pfam02080
339671000109	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
339671000110	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
339671000111	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
339671000112	ATP binding site [chemical binding]; other site
339671000113	Mg++ binding site [ion binding]; other site
339671000114	motif III; other site
339671000115	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
339671000116	nucleotide binding region [chemical binding]; other site
339671000117	ATP-binding site [chemical binding]; other site
339671000118	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
339671000119	non-specific DNA binding site [nucleotide binding]; other site
339671000120	salt bridge; other site
339671000121	sequence-specific DNA binding site [nucleotide binding]; other site
339671000122	YecR-like lipoprotein; Region: YecR; pfam13992
339671000123	adenylosuccinate lyase; Provisional; Region: PRK09285
339671000124	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
339671000125	tetramer interface [polypeptide binding]; other site
339671000126	active site
339671000127	putative lysogenization regulator; Reviewed; Region: PRK00218
339671000128	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
339671000129	active site
339671000130	DNA binding site [nucleotide binding]
339671000131	Int/Topo IB signature motif; other site
339671000132	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
339671000133	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671000134	active site
339671000135	motif I; other site
339671000136	motif II; other site
339671000137	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
339671000138	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
339671000139	Walker A/P-loop; other site
339671000140	ATP binding site [chemical binding]; other site
339671000141	Q-loop/lid; other site
339671000142	ABC transporter signature motif; other site
339671000143	Walker B; other site
339671000144	D-loop; other site
339671000145	H-loop/switch region; other site
339671000146	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
339671000147	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671000148	dimer interface [polypeptide binding]; other site
339671000149	conserved gate region; other site
339671000150	ABC-ATPase subunit interface; other site
339671000151	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
339671000152	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
339671000153	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
339671000154	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
339671000155	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
339671000156	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
339671000157	RNA binding surface [nucleotide binding]; other site
339671000158	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
339671000159	active site
339671000160	Outer membrane lipoprotein; Region: YfiO; pfam13525
339671000161	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
339671000162	binding surface
339671000163	TPR motif; other site
339671000164	transcription termination factor Rho; Provisional; Region: rho; PRK09376
339671000165	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
339671000166	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
339671000167	RNA binding site [nucleotide binding]; other site
339671000168	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
339671000169	multimer interface [polypeptide binding]; other site
339671000170	Walker A motif; other site
339671000171	ATP binding site [chemical binding]; other site
339671000172	Walker B motif; other site
339671000173	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
339671000174	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
339671000175	ATP binding site [chemical binding]; other site
339671000176	Mg++ binding site [ion binding]; other site
339671000177	motif III; other site
339671000178	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
339671000179	nucleotide binding region [chemical binding]; other site
339671000180	ATP-binding site [chemical binding]; other site
339671000181	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
339671000182	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
339671000183	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
339671000184	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
339671000185	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
339671000186	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
339671000187	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
339671000188	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
339671000189	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
339671000190	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
339671000191	DNA binding site [nucleotide binding]
339671000192	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
339671000193	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
339671000194	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
339671000195	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
339671000196	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
339671000197	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
339671000198	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
339671000199	RPB3 interaction site [polypeptide binding]; other site
339671000200	RPB1 interaction site [polypeptide binding]; other site
339671000201	RPB11 interaction site [polypeptide binding]; other site
339671000202	RPB10 interaction site [polypeptide binding]; other site
339671000203	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
339671000204	core dimer interface [polypeptide binding]; other site
339671000205	peripheral dimer interface [polypeptide binding]; other site
339671000206	L10 interface [polypeptide binding]; other site
339671000207	L11 interface [polypeptide binding]; other site
339671000208	putative EF-Tu interaction site [polypeptide binding]; other site
339671000209	putative EF-G interaction site [polypeptide binding]; other site
339671000210	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
339671000211	23S rRNA interface [nucleotide binding]; other site
339671000212	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
339671000213	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
339671000214	mRNA/rRNA interface [nucleotide binding]; other site
339671000215	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
339671000216	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
339671000217	23S rRNA interface [nucleotide binding]; other site
339671000218	L7/L12 interface [polypeptide binding]; other site
339671000219	putative thiostrepton binding site; other site
339671000220	L25 interface [polypeptide binding]; other site
339671000221	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
339671000222	active site
339671000223	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
339671000224	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
339671000225	putative homodimer interface [polypeptide binding]; other site
339671000226	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
339671000227	heterodimer interface [polypeptide binding]; other site
339671000228	homodimer interface [polypeptide binding]; other site
339671000229	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
339671000230	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
339671000231	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
339671000232	active site
339671000233	tetramer interface; other site
339671000234	phosphomannomutase CpsG; Provisional; Region: PRK15414
339671000235	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
339671000236	active site
339671000237	substrate binding site [chemical binding]; other site
339671000238	metal binding site [ion binding]; metal-binding site
339671000239	carbon storage regulator; Provisional; Region: PRK01712
339671000240	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
339671000241	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
339671000242	motif 1; other site
339671000243	active site
339671000244	motif 2; other site
339671000245	motif 3; other site
339671000246	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
339671000247	DHHA1 domain; Region: DHHA1; pfam02272
339671000248	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
339671000249	Ligand Binding Site [chemical binding]; other site
339671000250	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
339671000251	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
339671000252	homodimer interface [polypeptide binding]; other site
339671000253	metal binding site [ion binding]; metal-binding site
339671000254	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
339671000255	homodimer interface [polypeptide binding]; other site
339671000256	active site
339671000257	putative chemical substrate binding site [chemical binding]; other site
339671000258	metal binding site [ion binding]; metal-binding site
339671000259	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
339671000260	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
339671000261	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
339671000262	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
339671000263	Phosphotransferase enzyme family; Region: APH; pfam01636
339671000264	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
339671000265	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
339671000266	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
339671000267	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671000268	Walker A/P-loop; other site
339671000269	ATP binding site [chemical binding]; other site
339671000270	Q-loop/lid; other site
339671000271	ABC transporter signature motif; other site
339671000272	Walker B; other site
339671000273	D-loop; other site
339671000274	H-loop/switch region; other site
339671000275	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
339671000276	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
339671000277	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
339671000278	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
339671000279	putative ADP-binding pocket [chemical binding]; other site
339671000280	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
339671000281	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
339671000282	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
339671000283	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
339671000284	eyelet of channel; other site
339671000285	trimer interface [polypeptide binding]; other site
339671000286	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
339671000287	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
339671000288	active site
339671000289	catalytic tetrad [active]
339671000290	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
339671000291	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
339671000292	conserved cys residue [active]
339671000293	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
339671000294	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
339671000295	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
339671000296	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
339671000297	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
339671000298	minor groove reading motif; other site
339671000299	helix-hairpin-helix signature motif; other site
339671000300	active site
339671000301	S-formylglutathione hydrolase; Region: PLN02442
339671000302	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
339671000303	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
339671000304	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
339671000305	substrate binding site [chemical binding]; other site
339671000306	catalytic Zn binding site [ion binding]; other site
339671000307	NAD binding site [chemical binding]; other site
339671000308	structural Zn binding site [ion binding]; other site
339671000309	dimer interface [polypeptide binding]; other site
339671000310	Protein of unknown function, DUF606; Region: DUF606; pfam04657
339671000311	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
339671000312	Uncharacterized conserved protein [Function unknown]; Region: COG4925
339671000313	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
339671000314	trimer interface [polypeptide binding]; other site
339671000315	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
339671000316	active site
339671000317	substrate binding site [chemical binding]; other site
339671000318	CoA binding site [chemical binding]; other site
339671000319	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
339671000320	recombination factor protein RarA; Reviewed; Region: PRK13342
339671000321	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671000322	Walker A motif; other site
339671000323	ATP binding site [chemical binding]; other site
339671000324	Walker B motif; other site
339671000325	arginine finger; other site
339671000326	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
339671000327	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
339671000328	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
339671000329	gating phenylalanine in ion channel; other site
339671000330	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
339671000331	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
339671000332	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671000333	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671000334	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
339671000335	dimerization interface [polypeptide binding]; other site
339671000336	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
339671000337	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671000338	putative substrate translocation pore; other site
339671000339	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671000340	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671000341	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
339671000342	putative effector binding pocket; other site
339671000343	dimerization interface [polypeptide binding]; other site
339671000344	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
339671000345	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
339671000346	ligand binding site [chemical binding]; other site
339671000347	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
339671000348	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
339671000349	Walker A/P-loop; other site
339671000350	ATP binding site [chemical binding]; other site
339671000351	Q-loop/lid; other site
339671000352	ABC transporter signature motif; other site
339671000353	Walker B; other site
339671000354	D-loop; other site
339671000355	H-loop/switch region; other site
339671000356	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
339671000357	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
339671000358	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
339671000359	TM-ABC transporter signature motif; other site
339671000360	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
339671000361	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
339671000362	putative N- and C-terminal domain interface [polypeptide binding]; other site
339671000363	putative active site [active]
339671000364	MgATP binding site [chemical binding]; other site
339671000365	catalytic site [active]
339671000366	metal binding site [ion binding]; metal-binding site
339671000367	putative xylulose binding site [chemical binding]; other site
339671000368	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
339671000369	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
339671000370	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
339671000371	active site
339671000372	P-loop; other site
339671000373	phosphorylation site [posttranslational modification]
339671000374	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
339671000375	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
339671000376	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
339671000377	putative substrate binding site [chemical binding]; other site
339671000378	putative ATP binding site [chemical binding]; other site
339671000379	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779
339671000380	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
339671000381	active site
339671000382	phosphorylation site [posttranslational modification]
339671000383	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
339671000384	dimerization domain swap beta strand [polypeptide binding]; other site
339671000385	regulatory protein interface [polypeptide binding]; other site
339671000386	active site
339671000387	regulatory phosphorylation site [posttranslational modification]; other site
339671000388	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
339671000389	dimerization domain swap beta strand [polypeptide binding]; other site
339671000390	regulatory protein interface [polypeptide binding]; other site
339671000391	active site
339671000392	regulatory phosphorylation site [posttranslational modification]; other site
339671000393	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
339671000394	active site residue [active]
339671000395	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
339671000396	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
339671000397	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
339671000398	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
339671000399	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
339671000400	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
339671000401	elongation factor Tu; Reviewed; Region: PRK00049
339671000402	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
339671000403	G1 box; other site
339671000404	GEF interaction site [polypeptide binding]; other site
339671000405	GTP/Mg2+ binding site [chemical binding]; other site
339671000406	Switch I region; other site
339671000407	G2 box; other site
339671000408	G3 box; other site
339671000409	Switch II region; other site
339671000410	G4 box; other site
339671000411	G5 box; other site
339671000412	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
339671000413	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
339671000414	Antibiotic Binding Site [chemical binding]; other site
339671000415	pantothenate kinase; Provisional; Region: PRK05439
339671000416	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
339671000417	ATP-binding site [chemical binding]; other site
339671000418	CoA-binding site [chemical binding]; other site
339671000419	Mg2+-binding site [ion binding]; other site
339671000420	tyrosine kinase; Provisional; Region: PRK11519
339671000421	Chain length determinant protein; Region: Wzz; pfam02706
339671000422	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
339671000423	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
339671000424	polysaccharide export protein Wza; Provisional; Region: PRK15078
339671000425	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
339671000426	SLBB domain; Region: SLBB; pfam10531
339671000427	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
339671000428	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
339671000429	NAD(P) binding site [chemical binding]; other site
339671000430	homodimer interface [polypeptide binding]; other site
339671000431	substrate binding site [chemical binding]; other site
339671000432	active site
339671000433	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
339671000434	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
339671000435	inhibitor-cofactor binding pocket; inhibition site
339671000436	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671000437	catalytic residue [active]
339671000438	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
339671000439	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
339671000440	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
339671000441	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
339671000442	Bacterial sugar transferase; Region: Bac_transf; pfam02397
339671000443	O-Antigen ligase; Region: Wzy_C; pfam04932
339671000444	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
339671000445	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
339671000446	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
339671000447	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
339671000448	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
339671000449	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
339671000450	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
339671000451	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
339671000452	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
339671000453	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
339671000454	inhibitor-cofactor binding pocket; inhibition site
339671000455	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671000456	catalytic residue [active]
339671000457	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
339671000458	putative CoA binding site [chemical binding]; other site
339671000459	putative trimer interface [polypeptide binding]; other site
339671000460	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
339671000461	putative trimer interface [polypeptide binding]; other site
339671000462	putative active site [active]
339671000463	putative substrate binding site [chemical binding]; other site
339671000464	putative CoA binding site [chemical binding]; other site
339671000465	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
339671000466	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
339671000467	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
339671000468	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
339671000469	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
339671000470	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
339671000471	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
339671000472	active site
339671000473	catalytic residues [active]
339671000474	metal binding site [ion binding]; metal-binding site
339671000475	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
339671000476	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
339671000477	putative active site [active]
339671000478	substrate binding site [chemical binding]; other site
339671000479	putative cosubstrate binding site; other site
339671000480	catalytic site [active]
339671000481	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
339671000482	substrate binding site [chemical binding]; other site
339671000483	16S rRNA methyltransferase B; Provisional; Region: PRK10901
339671000484	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
339671000485	putative RNA binding site [nucleotide binding]; other site
339671000486	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671000487	S-adenosylmethionine binding site [chemical binding]; other site
339671000488	Predicted membrane protein [Function unknown]; Region: COG1297
339671000489	putative oligopeptide transporter, OPT family; Region: TIGR00733
339671000490	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
339671000491	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
339671000492	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
339671000493	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
339671000494	Predicted peptidase [General function prediction only]; Region: COG4099
339671000495	fructuronate transporter; Provisional; Region: PRK10034; cl15264
339671000496	GntP family permease; Region: GntP_permease; pfam02447
339671000497	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
339671000498	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
339671000499	Metal-binding active site; metal-binding site
339671000500	putative aldolase; Validated; Region: PRK08130
339671000501	intersubunit interface [polypeptide binding]; other site
339671000502	active site
339671000503	Zn2+ binding site [ion binding]; other site
339671000504	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
339671000505	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
339671000506	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
339671000507	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
339671000508	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
339671000509	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
339671000510	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
339671000511	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
339671000512	active site
339671000513	metal binding site [ion binding]; metal-binding site
339671000514	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
339671000515	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
339671000516	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
339671000517	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
339671000518	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
339671000519	HPr interaction site; other site
339671000520	glycerol kinase (GK) interaction site [polypeptide binding]; other site
339671000521	active site
339671000522	phosphorylation site [posttranslational modification]
339671000523	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
339671000524	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
339671000525	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
339671000526	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
339671000527	putative N- and C-terminal domain interface [polypeptide binding]; other site
339671000528	putative active site [active]
339671000529	MgATP binding site [chemical binding]; other site
339671000530	catalytic site [active]
339671000531	metal binding site [ion binding]; metal-binding site
339671000532	putative carbohydrate binding site [chemical binding]; other site
339671000533	short chain dehydrogenase; Provisional; Region: PRK05867
339671000534	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
339671000535	NAD(P) binding site [chemical binding]; other site
339671000536	active site
339671000537	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
339671000538	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
339671000539	nucleotide binding site [chemical binding]; other site
339671000540	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
339671000541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
339671000542	ATP binding site [chemical binding]; other site
339671000543	Mg2+ binding site [ion binding]; other site
339671000544	G-X-G motif; other site
339671000545	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
339671000546	anchoring element; other site
339671000547	dimer interface [polypeptide binding]; other site
339671000548	ATP binding site [chemical binding]; other site
339671000549	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
339671000550	active site
339671000551	putative metal-binding site [ion binding]; other site
339671000552	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
339671000553	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
339671000554	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
339671000555	active site 1 [active]
339671000556	dimer interface [polypeptide binding]; other site
339671000557	hexamer interface [polypeptide binding]; other site
339671000558	active site 2 [active]
339671000559	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
339671000560	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
339671000561	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671000562	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671000563	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
339671000564	dimerization interface [polypeptide binding]; other site
339671000565	tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185
339671000566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
339671000567	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
339671000568	Low molecular weight phosphatase family; Region: LMWPc; cd00115
339671000569	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
339671000570	active site
339671000571	homotetramer interface [polypeptide binding]; other site
339671000572	homodimer interface [polypeptide binding]; other site
339671000573	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
339671000574	Aspartase; Region: Aspartase; cd01357
339671000575	active sites [active]
339671000576	tetramer interface [polypeptide binding]; other site
339671000577	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
339671000578	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
339671000579	hypothetical protein; Provisional; Region: PRK05421
339671000580	putative catalytic site [active]
339671000581	putative metal binding site [ion binding]; other site
339671000582	putative phosphate binding site [ion binding]; other site
339671000583	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
339671000584	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
339671000585	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
339671000586	putative active site [active]
339671000587	catalytic site [active]
339671000588	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
339671000589	putative active site [active]
339671000590	catalytic site [active]
339671000591	Glucuronate isomerase; Region: UxaC; pfam02614
339671000592	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
339671000593	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
339671000594	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
339671000595	membrane-bound complex binding site; other site
339671000596	hinge residues; other site
339671000597	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
339671000598	DctM-like transporters; Region: DctM; pfam06808
339671000599	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
339671000600	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
339671000601	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
339671000602	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
339671000603	putative active site [active]
339671000604	putative catalytic site [active]
339671000605	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
339671000606	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
339671000607	DNA-binding site [nucleotide binding]; DNA binding site
339671000608	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
339671000609	mannonate dehydratase; Provisional; Region: PRK03906
339671000610	mannonate dehydratase; Region: uxuA; TIGR00695
339671000611	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
339671000612	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
339671000613	active site
339671000614	intersubunit interface [polypeptide binding]; other site
339671000615	catalytic residue [active]
339671000616	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
339671000617	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
339671000618	substrate binding site [chemical binding]; other site
339671000619	ATP binding site [chemical binding]; other site
339671000620	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
339671000621	galactarate dehydratase; Region: galactar-dH20; TIGR03248
339671000622	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
339671000623	altronate oxidoreductase; Provisional; Region: PRK03643
339671000624	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
339671000625	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
339671000626	DctM-like transporters; Region: DctM; pfam06808
339671000627	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
339671000628	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
339671000629	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
339671000630	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
339671000631	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
339671000632	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
339671000633	putative NAD(P) binding site [chemical binding]; other site
339671000634	catalytic Zn binding site [ion binding]; other site
339671000635	structural Zn binding site [ion binding]; other site
339671000636	Transcriptional regulators [Transcription]; Region: GntR; COG1802
339671000637	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
339671000638	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
339671000639	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
339671000640	Coenzyme A binding pocket [chemical binding]; other site
339671000641	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
339671000642	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
339671000643	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
339671000644	dimerization interface [polypeptide binding]; other site
339671000645	Histidine kinase; Region: HisKA_3; pfam07730
339671000646	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
339671000647	ATP binding site [chemical binding]; other site
339671000648	Mg2+ binding site [ion binding]; other site
339671000649	G-X-G motif; other site
339671000650	Ferritin-like domain; Region: Ferritin; pfam00210
339671000651	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
339671000652	dimerization interface [polypeptide binding]; other site
339671000653	DPS ferroxidase diiron center [ion binding]; other site
339671000654	ion pore; other site
339671000655	conserved hypothetical protein; Region: TIGR00743
339671000656	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
339671000657	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
339671000658	putative ion selectivity filter; other site
339671000659	putative pore gating glutamate residue; other site
339671000660	glutamine synthetase; Provisional; Region: glnA; PRK09469
339671000661	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
339671000662	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
339671000663	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
339671000664	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
339671000665	G1 box; other site
339671000666	putative GEF interaction site [polypeptide binding]; other site
339671000667	GTP/Mg2+ binding site [chemical binding]; other site
339671000668	Switch I region; other site
339671000669	G2 box; other site
339671000670	G3 box; other site
339671000671	Switch II region; other site
339671000672	G4 box; other site
339671000673	G5 box; other site
339671000674	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
339671000675	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
339671000676	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
339671000677	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
339671000678	hexamer (dimer of trimers) interface [polypeptide binding]; other site
339671000679	substrate binding site [chemical binding]; other site
339671000680	trimer interface [polypeptide binding]; other site
339671000681	Mn binding site [ion binding]; other site
339671000682	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
339671000683	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
339671000684	N- and C-terminal domain interface [polypeptide binding]; other site
339671000685	active site
339671000686	MgATP binding site [chemical binding]; other site
339671000687	catalytic site [active]
339671000688	metal binding site [ion binding]; metal-binding site
339671000689	putative homotetramer interface [polypeptide binding]; other site
339671000690	putative homodimer interface [polypeptide binding]; other site
339671000691	glycerol binding site [chemical binding]; other site
339671000692	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
339671000693	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
339671000694	PYR/PP interface [polypeptide binding]; other site
339671000695	dimer interface [polypeptide binding]; other site
339671000696	TPP binding site [chemical binding]; other site
339671000697	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
339671000698	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
339671000699	TPP-binding site [chemical binding]; other site
339671000700	dimer interface [polypeptide binding]; other site
339671000701	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
339671000702	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
339671000703	TM-ABC transporter signature motif; other site
339671000704	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
339671000705	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
339671000706	Walker A/P-loop; other site
339671000707	ATP binding site [chemical binding]; other site
339671000708	Q-loop/lid; other site
339671000709	ABC transporter signature motif; other site
339671000710	Walker B; other site
339671000711	D-loop; other site
339671000712	H-loop/switch region; other site
339671000713	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
339671000714	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054
339671000715	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
339671000716	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
339671000717	ligand binding site [chemical binding]; other site
339671000718	dimerization interface [polypeptide binding]; other site
339671000719	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
339671000720	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
339671000721	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792
339671000722	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
339671000723	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
339671000724	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
339671000725	metal binding site [ion binding]; metal-binding site
339671000726	dimer interface [polypeptide binding]; other site
339671000727	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
339671000728	active site
339671000729	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
339671000730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671000731	dimer interface [polypeptide binding]; other site
339671000732	conserved gate region; other site
339671000733	putative PBP binding loops; other site
339671000734	ABC-ATPase subunit interface; other site
339671000735	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671000736	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
339671000737	Walker A/P-loop; other site
339671000738	ATP binding site [chemical binding]; other site
339671000739	Q-loop/lid; other site
339671000740	ABC transporter signature motif; other site
339671000741	Walker B; other site
339671000742	D-loop; other site
339671000743	H-loop/switch region; other site
339671000744	prolyl-tRNA synthetase; Provisional; Region: PRK09194
339671000745	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
339671000746	dimer interface [polypeptide binding]; other site
339671000747	motif 1; other site
339671000748	active site
339671000749	motif 2; other site
339671000750	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
339671000751	putative deacylase active site [active]
339671000752	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
339671000753	active site
339671000754	motif 3; other site
339671000755	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
339671000756	anticodon binding site; other site
339671000757	Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939
339671000758	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
339671000759	transmembrane helices; other site
339671000760	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
339671000761	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
339671000762	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
339671000763	substrate binding site [chemical binding]; other site
339671000764	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
339671000765	substrate binding site [chemical binding]; other site
339671000766	ligand binding site [chemical binding]; other site
339671000767	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
339671000768	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
339671000769	DNA-binding site [nucleotide binding]; DNA binding site
339671000770	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
339671000771	glutathionine S-transferase; Provisional; Region: PRK10542
339671000772	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
339671000773	C-terminal domain interface [polypeptide binding]; other site
339671000774	GSH binding site (G-site) [chemical binding]; other site
339671000775	dimer interface [polypeptide binding]; other site
339671000776	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
339671000777	N-terminal domain interface [polypeptide binding]; other site
339671000778	dimer interface [polypeptide binding]; other site
339671000779	substrate binding pocket (H-site) [chemical binding]; other site
339671000780	diaminopimelate decarboxylase; Region: lysA; TIGR01048
339671000781	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
339671000782	active site
339671000783	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
339671000784	substrate binding site [chemical binding]; other site
339671000785	catalytic residues [active]
339671000786	dimer interface [polypeptide binding]; other site
339671000787	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
339671000788	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
339671000789	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
339671000790	HD domain; Region: HD_4; pfam13328
339671000791	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
339671000792	synthetase active site [active]
339671000793	NTP binding site [chemical binding]; other site
339671000794	metal binding site [ion binding]; metal-binding site
339671000795	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
339671000796	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
339671000797	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
339671000798	TRAM domain; Region: TRAM; pfam01938
339671000799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671000800	S-adenosylmethionine binding site [chemical binding]; other site
339671000801	Recombination protein O N terminal; Region: RecO_N; pfam11967
339671000802	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
339671000803	Recombination protein O C terminal; Region: RecO_C; pfam02565
339671000804	D-ribose pyranase; Provisional; Region: PRK11797
339671000805	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
339671000806	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
339671000807	Walker A/P-loop; other site
339671000808	ATP binding site [chemical binding]; other site
339671000809	Q-loop/lid; other site
339671000810	ABC transporter signature motif; other site
339671000811	Walker B; other site
339671000812	D-loop; other site
339671000813	H-loop/switch region; other site
339671000814	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
339671000815	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
339671000816	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
339671000817	TM-ABC transporter signature motif; other site
339671000818	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
339671000819	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
339671000820	ligand binding site [chemical binding]; other site
339671000821	dimerization interface [polypeptide binding]; other site
339671000822	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
339671000823	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
339671000824	substrate binding site [chemical binding]; other site
339671000825	dimer interface [polypeptide binding]; other site
339671000826	ATP binding site [chemical binding]; other site
339671000827	transcriptional repressor RbsR; Provisional; Region: PRK10423
339671000828	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
339671000829	DNA binding site [nucleotide binding]
339671000830	domain linker motif; other site
339671000831	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
339671000832	dimerization interface [polypeptide binding]; other site
339671000833	ligand binding site [chemical binding]; other site
339671000834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
339671000835	RNA methyltransferase, RsmE family; Region: TIGR00046
339671000836	hypothetical protein; Validated; Region: PRK00228
339671000837	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
339671000838	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
339671000839	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
339671000840	Cysteine-rich domain; Region: CCG; pfam02754
339671000841	Cysteine-rich domain; Region: CCG; pfam02754
339671000842	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
339671000843	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
339671000844	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
339671000845	Uncharacterized conserved protein [Function unknown]; Region: COG1359
339671000846	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
339671000847	Pyruvate formate lyase 1; Region: PFL1; cd01678
339671000848	coenzyme A binding site [chemical binding]; other site
339671000849	active site
339671000850	catalytic residues [active]
339671000851	glycine loop; other site
339671000852	formate transporter FocA; Region: formate_focA; TIGR04060
339671000853	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
339671000854	nucleotide binding site/active site [active]
339671000855	HIT family signature motif; other site
339671000856	catalytic residue [active]
339671000857	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
339671000858	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
339671000859	putative dimer interface [polypeptide binding]; other site
339671000860	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
339671000861	beta-hexosaminidase; Provisional; Region: PRK05337
339671000862	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
339671000863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671000864	S-adenosylmethionine binding site [chemical binding]; other site
339671000865	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
339671000866	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
339671000867	putative active site pocket [active]
339671000868	metal binding site [ion binding]; metal-binding site
339671000869	cell density-dependent motility repressor; Provisional; Region: PRK10082
339671000870	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671000871	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
339671000872	dimerization interface [polypeptide binding]; other site
339671000873	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671000874	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671000875	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
339671000876	dimerization interface [polypeptide binding]; other site
339671000877	Lysine efflux permease [General function prediction only]; Region: COG1279
339671000878	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
339671000879	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
339671000880	substrate binding site [chemical binding]; other site
339671000881	hexamer interface [polypeptide binding]; other site
339671000882	metal binding site [ion binding]; metal-binding site
339671000883	phosphoglycolate phosphatase; Provisional; Region: PRK13222
339671000884	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
339671000885	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671000886	motif II; other site
339671000887	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
339671000888	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
339671000889	active site
339671000890	HIGH motif; other site
339671000891	dimer interface [polypeptide binding]; other site
339671000892	KMSKS motif; other site
339671000893	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
339671000894	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
339671000895	active site
339671000896	substrate-binding site [chemical binding]; other site
339671000897	metal-binding site [ion binding]
339671000898	ATP binding site [chemical binding]; other site
339671000899	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
339671000900	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
339671000901	dimerization interface [polypeptide binding]; other site
339671000902	domain crossover interface; other site
339671000903	redox-dependent activation switch; other site
339671000904	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
339671000905	RNA binding surface [nucleotide binding]; other site
339671000906	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
339671000907	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
339671000908	ADP-ribose binding site [chemical binding]; other site
339671000909	dimer interface [polypeptide binding]; other site
339671000910	active site
339671000911	nudix motif; other site
339671000912	metal binding site [ion binding]; metal-binding site
339671000913	malonic semialdehyde reductase; Provisional; Region: PRK10538
339671000914	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
339671000915	putative NAD(P) binding site [chemical binding]; other site
339671000916	homotetramer interface [polypeptide binding]; other site
339671000917	homodimer interface [polypeptide binding]; other site
339671000918	active site
339671000919	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
339671000920	active site
339671000921	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
339671000922	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
339671000923	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
339671000924	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
339671000925	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
339671000926	putative active site [active]
339671000927	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
339671000928	aspartate racemase; Region: asp_race; TIGR00035
339671000929	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
339671000930	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
339671000931	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
339671000932	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
339671000933	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
339671000934	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
339671000935	intersubunit interface [polypeptide binding]; other site
339671000936	active site
339671000937	Zn2+ binding site [ion binding]; other site
339671000938	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
339671000939	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
339671000940	AP (apurinic/apyrimidinic) site pocket; other site
339671000941	DNA interaction; other site
339671000942	Metal-binding active site; metal-binding site
339671000943	transcriptional repressor UlaR; Provisional; Region: PRK13509
339671000944	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
339671000945	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
339671000946	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
339671000947	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
339671000948	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
339671000949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
339671000950	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
339671000951	active site
339671000952	P-loop; other site
339671000953	phosphorylation site [posttranslational modification]
339671000954	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
339671000955	active site
339671000956	phosphorylation site [posttranslational modification]
339671000957	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
339671000958	active site
339671000959	dimer interface [polypeptide binding]; other site
339671000960	magnesium binding site [ion binding]; other site
339671000961	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
339671000962	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
339671000963	Protein of unknown function (DUF541); Region: SIMPL; cl01077
339671000964	RNase E inhibitor protein; Provisional; Region: PRK11191
339671000965	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
339671000966	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
339671000967	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
339671000968	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
339671000969	TrkA-N domain; Region: TrkA_N; pfam02254
339671000970	TrkA-C domain; Region: TrkA_C; pfam02080
339671000971	TrkA-N domain; Region: TrkA_N; pfam02254
339671000972	TrkA-C domain; Region: TrkA_C; pfam02080
339671000973	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
339671000974	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
339671000975	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
339671000976	Uncharacterized conserved protein [Function unknown]; Region: COG2938
339671000977	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
339671000978	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
339671000979	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
339671000980	DNA binding residues [nucleotide binding]
339671000981	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
339671000982	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
339671000983	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
339671000984	anti-sigma E factor; Provisional; Region: rseB; PRK09455
339671000985	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
339671000986	Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086
339671000987	argininosuccinate lyase; Provisional; Region: PRK04833
339671000988	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
339671000989	active sites [active]
339671000990	tetramer interface [polypeptide binding]; other site
339671000991	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
339671000992	nucleotide binding site [chemical binding]; other site
339671000993	N-acetyl-L-glutamate binding site [chemical binding]; other site
339671000994	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
339671000995	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
339671000996	acetylornithine deacetylase; Provisional; Region: PRK05111
339671000997	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
339671000998	metal binding site [ion binding]; metal-binding site
339671000999	putative dimer interface [polypeptide binding]; other site
339671001000	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
339671001001	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
339671001002	putative active site [active]
339671001003	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
339671001004	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
339671001005	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
339671001006	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
339671001007	Walker A/P-loop; other site
339671001008	ATP binding site [chemical binding]; other site
339671001009	Q-loop/lid; other site
339671001010	ABC transporter signature motif; other site
339671001011	Walker B; other site
339671001012	D-loop; other site
339671001013	H-loop/switch region; other site
339671001014	recombination regulator RecX; Reviewed; Region: recX; PRK00117
339671001015	recombinase A; Provisional; Region: recA; PRK09354
339671001016	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
339671001017	hexamer interface [polypeptide binding]; other site
339671001018	Walker A motif; other site
339671001019	ATP binding site [chemical binding]; other site
339671001020	Walker B motif; other site
339671001021	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
339671001022	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
339671001023	active site
339671001024	dimer interface [polypeptide binding]; other site
339671001025	metal binding site [ion binding]; metal-binding site
339671001026	shikimate kinase; Reviewed; Region: aroK; PRK00131
339671001027	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
339671001028	ADP binding site [chemical binding]; other site
339671001029	magnesium binding site [ion binding]; other site
339671001030	putative shikimate binding site; other site
339671001031	transketolase; Reviewed; Region: PRK12753
339671001032	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
339671001033	TPP-binding site [chemical binding]; other site
339671001034	dimer interface [polypeptide binding]; other site
339671001035	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
339671001036	PYR/PP interface [polypeptide binding]; other site
339671001037	dimer interface [polypeptide binding]; other site
339671001038	TPP binding site [chemical binding]; other site
339671001039	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
339671001040	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
339671001041	Transcriptional regulator [Transcription]; Region: IclR; COG1414
339671001042	Bacterial transcriptional regulator; Region: IclR; pfam01614
339671001043	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
339671001044	Domain of unknown function (DUF386); Region: DUF386; pfam04074
339671001045	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
339671001046	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
339671001047	DctM-like transporters; Region: DctM; pfam06808
339671001048	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
339671001049	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
339671001050	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
339671001051	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
339671001052	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
339671001053	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
339671001054	putative N- and C-terminal domain interface [polypeptide binding]; other site
339671001055	putative active site [active]
339671001056	MgATP binding site [chemical binding]; other site
339671001057	catalytic site [active]
339671001058	metal binding site [ion binding]; metal-binding site
339671001059	putative xylulose binding site [chemical binding]; other site
339671001060	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
339671001061	Sodium Bile acid symporter family; Region: SBF; cl17470
339671001062	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
339671001063	Mechanosensitive ion channel; Region: MS_channel; pfam00924
339671001064	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
339671001065	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
339671001066	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
339671001067	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
339671001068	elongation factor Tu; Reviewed; Region: PRK00049
339671001069	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
339671001070	G1 box; other site
339671001071	GEF interaction site [polypeptide binding]; other site
339671001072	GTP/Mg2+ binding site [chemical binding]; other site
339671001073	Switch I region; other site
339671001074	G2 box; other site
339671001075	G3 box; other site
339671001076	Switch II region; other site
339671001077	G4 box; other site
339671001078	G5 box; other site
339671001079	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
339671001080	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
339671001081	Antibiotic Binding Site [chemical binding]; other site
339671001082	elongation factor G; Reviewed; Region: PRK00007
339671001083	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
339671001084	G1 box; other site
339671001085	putative GEF interaction site [polypeptide binding]; other site
339671001086	GTP/Mg2+ binding site [chemical binding]; other site
339671001087	Switch I region; other site
339671001088	G2 box; other site
339671001089	G3 box; other site
339671001090	Switch II region; other site
339671001091	G4 box; other site
339671001092	G5 box; other site
339671001093	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
339671001094	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
339671001095	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
339671001096	30S ribosomal protein S7; Validated; Region: PRK05302
339671001097	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
339671001098	S17 interaction site [polypeptide binding]; other site
339671001099	S8 interaction site; other site
339671001100	16S rRNA interaction site [nucleotide binding]; other site
339671001101	streptomycin interaction site [chemical binding]; other site
339671001102	23S rRNA interaction site [nucleotide binding]; other site
339671001103	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
339671001104	TfoX N-terminal domain; Region: TfoX_N; pfam04993
339671001105	TfoX C-terminal domain; Region: TfoX_C; pfam04994
339671001106	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
339671001107	Na2 binding site [ion binding]; other site
339671001108	putative substrate binding site 1 [chemical binding]; other site
339671001109	Na binding site 1 [ion binding]; other site
339671001110	putative substrate binding site 2 [chemical binding]; other site
339671001111	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
339671001112	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
339671001113	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
339671001114	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
339671001115	active pocket/dimerization site; other site
339671001116	active site
339671001117	phosphorylation site [posttranslational modification]
339671001118	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
339671001119	active site
339671001120	phosphorylation site [posttranslational modification]
339671001121	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
339671001122	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
339671001123	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
339671001124	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
339671001125	Walker A motif; other site
339671001126	putative transporter; Provisional; Region: PRK10504
339671001127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671001128	putative substrate translocation pore; other site
339671001129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671001130	MgtC family; Region: MgtC; pfam02308
339671001131	DNA utilization protein GntX; Provisional; Region: PRK11595
339671001132	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
339671001133	active site
339671001134	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
339671001135	nudix motif; other site
339671001136	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
339671001137	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
339671001138	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
339671001139	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
339671001140	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
339671001141	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
339671001142	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
339671001143	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
339671001144	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
339671001145	substrate binding pocket [chemical binding]; other site
339671001146	membrane-bound complex binding site; other site
339671001147	hinge residues; other site
339671001148	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
339671001149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671001150	dimer interface [polypeptide binding]; other site
339671001151	conserved gate region; other site
339671001152	putative PBP binding loops; other site
339671001153	ABC-ATPase subunit interface; other site
339671001154	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
339671001155	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
339671001156	Walker A/P-loop; other site
339671001157	ATP binding site [chemical binding]; other site
339671001158	Q-loop/lid; other site
339671001159	ABC transporter signature motif; other site
339671001160	Walker B; other site
339671001161	D-loop; other site
339671001162	H-loop/switch region; other site
339671001163	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
339671001164	oxaloacetate decarboxylase; Provisional; Region: PRK14040
339671001165	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
339671001166	active site
339671001167	catalytic residues [active]
339671001168	metal binding site [ion binding]; metal-binding site
339671001169	homodimer binding site [polypeptide binding]; other site
339671001170	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
339671001171	carboxyltransferase (CT) interaction site; other site
339671001172	biotinylation site [posttranslational modification]; other site
339671001173	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
339671001174	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
339671001175	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
339671001176	transmembrane helices; other site
339671001177	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
339671001178	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
339671001179	putative active site [active]
339671001180	(T/H)XGH motif; other site
339671001181	hypothetical protein; Provisional; Region: PRK11027
339671001182	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
339671001183	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
339671001184	catalytic residues [active]
339671001185	hinge region; other site
339671001186	alpha helical domain; other site
339671001187	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
339671001188	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
339671001189	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
339671001190	GTP binding site; other site
339671001191	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
339671001192	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
339671001193	active site
339671001194	catalytic tetrad [active]
339671001195	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
339671001196	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
339671001197	maltodextrin phosphorylase; Provisional; Region: PRK14985
339671001198	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
339671001199	homodimer interface [polypeptide binding]; other site
339671001200	active site pocket [active]
339671001201	transcriptional regulator MalT; Provisional; Region: PRK04841
339671001202	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
339671001203	binding surface
339671001204	TPR motif; other site
339671001205	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
339671001206	DNA binding residues [nucleotide binding]
339671001207	dimerization interface [polypeptide binding]; other site
339671001208	alpha-amylase; Reviewed; Region: malS; PRK09505
339671001209	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
339671001210	active site
339671001211	catalytic site [active]
339671001212	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
339671001213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671001214	dimer interface [polypeptide binding]; other site
339671001215	conserved gate region; other site
339671001216	putative PBP binding loops; other site
339671001217	ABC-ATPase subunit interface; other site
339671001218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671001219	dimer interface [polypeptide binding]; other site
339671001220	conserved gate region; other site
339671001221	putative PBP binding loops; other site
339671001222	ABC-ATPase subunit interface; other site
339671001223	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
339671001224	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
339671001225	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
339671001226	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
339671001227	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
339671001228	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
339671001229	Walker A/P-loop; other site
339671001230	ATP binding site [chemical binding]; other site
339671001231	Q-loop/lid; other site
339671001232	ABC transporter signature motif; other site
339671001233	Walker B; other site
339671001234	D-loop; other site
339671001235	H-loop/switch region; other site
339671001236	TOBE domain; Region: TOBE_2; pfam08402
339671001237	trehalose synthase; Region: treS_nterm; TIGR02456
339671001238	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
339671001239	active site
339671001240	catalytic site [active]
339671001241	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
339671001242	trimer interface; other site
339671001243	sugar binding site [chemical binding]; other site
339671001244	maltose regulon periplasmic protein; Provisional; Region: PRK10564
339671001245	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671001246	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
339671001247	active site
339671001248	motif I; other site
339671001249	motif II; other site
339671001250	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671001251	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
339671001252	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
339671001253	gamma subunit interface [polypeptide binding]; other site
339671001254	epsilon subunit interface [polypeptide binding]; other site
339671001255	LBP interface [polypeptide binding]; other site
339671001256	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
339671001257	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
339671001258	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
339671001259	alpha subunit interaction interface [polypeptide binding]; other site
339671001260	Walker A motif; other site
339671001261	ATP binding site [chemical binding]; other site
339671001262	Walker B motif; other site
339671001263	inhibitor binding site; inhibition site
339671001264	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
339671001265	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
339671001266	core domain interface [polypeptide binding]; other site
339671001267	delta subunit interface [polypeptide binding]; other site
339671001268	epsilon subunit interface [polypeptide binding]; other site
339671001269	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
339671001270	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
339671001271	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
339671001272	beta subunit interaction interface [polypeptide binding]; other site
339671001273	Walker A motif; other site
339671001274	ATP binding site [chemical binding]; other site
339671001275	Walker B motif; other site
339671001276	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
339671001277	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
339671001278	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
339671001279	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
339671001280	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
339671001281	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
339671001282	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
339671001283	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
339671001284	F0F1 ATP synthase subunit I; Validated; Region: PRK06099
339671001285	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
339671001286	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
339671001287	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
339671001288	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
339671001289	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
339671001290	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
339671001291	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
339671001292	OstA-like protein; Region: OstA; pfam03968
339671001293	Organic solvent tolerance protein; Region: OstA_C; pfam04453
339671001294	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
339671001295	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
339671001296	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
339671001297	shikimate binding site; other site
339671001298	NAD(P) binding site [chemical binding]; other site
339671001299	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
339671001300	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
339671001301	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
339671001302	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
339671001303	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
339671001304	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
339671001305	RmuC family; Region: RmuC; pfam02646
339671001306	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
339671001307	putative active site [active]
339671001308	dimerization interface [polypeptide binding]; other site
339671001309	putative tRNAtyr binding site [nucleotide binding]; other site
339671001310	hypothetical protein; Reviewed; Region: PRK01637
339671001311	hypothetical protein; Provisional; Region: PRK01752
339671001312	SEC-C motif; Region: SEC-C; pfam02810
339671001313	SEC-C motif; Region: SEC-C; pfam02810
339671001314	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
339671001315	Domain of unknown function DUF87; Region: DUF87; pfam01935
339671001316	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
339671001317	MutS domain I; Region: MutS_I; pfam01624
339671001318	MutS domain II; Region: MutS_II; pfam05188
339671001319	MutS domain III; Region: MutS_III; pfam05192
339671001320	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
339671001321	Walker A/P-loop; other site
339671001322	ATP binding site [chemical binding]; other site
339671001323	Q-loop/lid; other site
339671001324	ABC transporter signature motif; other site
339671001325	Walker B; other site
339671001326	D-loop; other site
339671001327	H-loop/switch region; other site
339671001328	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
339671001329	putative iron binding site [ion binding]; other site
339671001330	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
339671001331	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
339671001332	ATP binding site [chemical binding]; other site
339671001333	putative Mg++ binding site [ion binding]; other site
339671001334	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
339671001335	nucleotide binding region [chemical binding]; other site
339671001336	ATP-binding site [chemical binding]; other site
339671001337	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
339671001338	HRDC domain; Region: HRDC; pfam00570
339671001339	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
339671001340	active site
339671001341	HslU subunit interaction site [polypeptide binding]; other site
339671001342	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
339671001343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671001344	Walker A motif; other site
339671001345	ATP binding site [chemical binding]; other site
339671001346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671001347	Walker B motif; other site
339671001348	arginine finger; other site
339671001349	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
339671001350	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
339671001351	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
339671001352	FAD binding pocket [chemical binding]; other site
339671001353	FAD binding motif [chemical binding]; other site
339671001354	phosphate binding motif [ion binding]; other site
339671001355	beta-alpha-beta structure motif; other site
339671001356	NAD binding pocket [chemical binding]; other site
339671001357	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
339671001358	catalytic loop [active]
339671001359	iron binding site [ion binding]; other site
339671001360	hybrid cluster protein; Provisional; Region: PRK05290
339671001361	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
339671001362	ACS interaction site; other site
339671001363	CODH interaction site; other site
339671001364	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
339671001365	ACS interaction site; other site
339671001366	CODH interaction site; other site
339671001367	metal cluster binding site [ion binding]; other site
339671001368	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
339671001369	HemY protein N-terminus; Region: HemY_N; pfam07219
339671001370	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
339671001371	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
339671001372	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
339671001373	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
339671001374	active site
339671001375	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
339671001376	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
339671001377	domain interfaces; other site
339671001378	active site
339671001379	Transcriptional regulators [Transcription]; Region: PurR; COG1609
339671001380	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
339671001381	DNA binding site [nucleotide binding]
339671001382	domain linker motif; other site
339671001383	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
339671001384	dimerization interface [polypeptide binding]; other site
339671001385	ligand binding site [chemical binding]; other site
339671001386	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
339671001387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671001388	putative substrate translocation pore; other site
339671001389	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
339671001390	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
339671001391	Metal-binding active site; metal-binding site
339671001392	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
339671001393	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
339671001394	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
339671001395	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
339671001396	adenylate cyclase; Provisional; Region: cyaA; PRK09450
339671001397	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
339671001398	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
339671001399	transcriptional regulator NarP; Provisional; Region: PRK10403
339671001400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
339671001401	active site
339671001402	phosphorylation site [posttranslational modification]
339671001403	intermolecular recognition site; other site
339671001404	dimerization interface [polypeptide binding]; other site
339671001405	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
339671001406	DNA binding residues [nucleotide binding]
339671001407	dimerization interface [polypeptide binding]; other site
339671001408	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
339671001409	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
339671001410	Surface antigen; Region: Bac_surface_Ag; pfam01103
339671001411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
339671001412	Family of unknown function (DUF490); Region: DUF490; pfam04357
339671001413	exopolyphosphatase; Provisional; Region: PRK10854
339671001414	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
339671001415	nucleotide binding site [chemical binding]; other site
339671001416	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
339671001417	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
339671001418	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
339671001419	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
339671001420	DctM-like transporters; Region: DctM; pfam06808
339671001421	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
339671001422	putative oxidoreductase; Provisional; Region: PRK10083
339671001423	putative NAD(P) binding site [chemical binding]; other site
339671001424	catalytic Zn binding site [ion binding]; other site
339671001425	structural Zn binding site [ion binding]; other site
339671001426	mannonate dehydratase; Provisional; Region: PRK03906
339671001427	mannonate dehydratase; Region: uxuA; TIGR00695
339671001428	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
339671001429	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
339671001430	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
339671001431	Transcriptional regulators [Transcription]; Region: FadR; COG2186
339671001432	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
339671001433	DNA-binding site [nucleotide binding]; DNA binding site
339671001434	FCD domain; Region: FCD; pfam07729
339671001435	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
339671001436	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
339671001437	substrate binding site [chemical binding]; other site
339671001438	ATP binding site [chemical binding]; other site
339671001439	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
339671001440	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
339671001441	active site
339671001442	intersubunit interface [polypeptide binding]; other site
339671001443	catalytic residue [active]
339671001444	glutamate dehydrogenase; Provisional; Region: PRK09414
339671001445	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
339671001446	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
339671001447	NAD(P) binding site [chemical binding]; other site
339671001448	Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513
339671001449	CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643
339671001450	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
339671001451	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
339671001452	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
339671001453	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
339671001454	catalytic triad [active]
339671001455	Der GTPase activator; Provisional; Region: PRK05244
339671001456	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
339671001457	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
339671001458	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671001459	FeS/SAM binding site; other site
339671001460	HemN C-terminal domain; Region: HemN_C; pfam06969
339671001461	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
339671001462	serine acetyltransferase; Provisional; Region: cysE; PRK11132
339671001463	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
339671001464	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
339671001465	trimer interface [polypeptide binding]; other site
339671001466	active site
339671001467	substrate binding site [chemical binding]; other site
339671001468	CoA binding site [chemical binding]; other site
339671001469	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
339671001470	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
339671001471	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
339671001472	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
339671001473	SecA binding site; other site
339671001474	Preprotein binding site; other site
339671001475	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
339671001476	active site residue [active]
339671001477	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
339671001478	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
339671001479	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
339671001480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671001481	Walker A/P-loop; other site
339671001482	ATP binding site [chemical binding]; other site
339671001483	Q-loop/lid; other site
339671001484	ABC transporter signature motif; other site
339671001485	Walker B; other site
339671001486	D-loop; other site
339671001487	H-loop/switch region; other site
339671001488	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
339671001489	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
339671001490	catalytic triad [active]
339671001491	dimer interface [polypeptide binding]; other site
339671001492	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
339671001493	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
339671001494	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671001495	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
339671001496	dimerization interface [polypeptide binding]; other site
339671001497	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
339671001498	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
339671001499	Protein of unknown function (DUF904); Region: DUF904; pfam06005
339671001500	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
339671001501	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
339671001502	putative active site [active]
339671001503	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
339671001504	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
339671001505	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
339671001506	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
339671001507	Sel1-like repeats; Region: SEL1; smart00671
339671001508	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
339671001509	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
339671001510	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
339671001511	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
339671001512	NADP binding site [chemical binding]; other site
339671001513	homopentamer interface [polypeptide binding]; other site
339671001514	substrate binding site [chemical binding]; other site
339671001515	active site
339671001516	FMN-binding protein MioC; Provisional; Region: PRK09004
339671001517	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
339671001518	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
339671001519	dimer interface [polypeptide binding]; other site
339671001520	active site
339671001521	metal binding site [ion binding]; metal-binding site
339671001522	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
339671001523	active site residue [active]
339671001524	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
339671001525	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
339671001526	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
339671001527	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671001528	FeS/SAM binding site; other site
339671001529	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
339671001530	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
339671001531	dimerization interface [polypeptide binding]; other site
339671001532	DNA binding site [nucleotide binding]
339671001533	corepressor binding sites; other site
339671001534	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
339671001535	amphipathic channel; other site
339671001536	Asn-Pro-Ala signature motifs; other site
339671001537	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
339671001538	dimer interface [polypeptide binding]; other site
339671001539	motif 1; other site
339671001540	active site
339671001541	motif 2; other site
339671001542	motif 3; other site
339671001543	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
339671001544	chromosome condensation membrane protein; Provisional; Region: PRK14196
339671001545	putative hydrolase; Provisional; Region: PRK10976
339671001546	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671001547	active site
339671001548	motif I; other site
339671001549	motif II; other site
339671001550	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671001551	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
339671001552	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
339671001553	PYR/PP interface [polypeptide binding]; other site
339671001554	dimer interface [polypeptide binding]; other site
339671001555	TPP binding site [chemical binding]; other site
339671001556	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
339671001557	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
339671001558	TPP-binding site [chemical binding]; other site
339671001559	dimer interface [polypeptide binding]; other site
339671001560	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
339671001561	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
339671001562	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
339671001563	threonine dehydratase; Reviewed; Region: PRK09224
339671001564	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
339671001565	tetramer interface [polypeptide binding]; other site
339671001566	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671001567	catalytic residue [active]
339671001568	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
339671001569	putative Ile/Val binding site [chemical binding]; other site
339671001570	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
339671001571	putative Ile/Val binding site [chemical binding]; other site
339671001572	putative global regulator; Reviewed; Region: PRK09559
339671001573	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
339671001574	hypothetical protein; Provisional; Region: PRK11820
339671001575	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
339671001576	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
339671001577	ribonuclease PH; Reviewed; Region: rph; PRK00173
339671001578	Ribonuclease PH; Region: RNase_PH_bact; cd11362
339671001579	hexamer interface [polypeptide binding]; other site
339671001580	active site
339671001581	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
339671001582	active site
339671001583	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
339671001584	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
339671001585	dimerization interface [polypeptide binding]; other site
339671001586	ATP binding site [chemical binding]; other site
339671001587	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
339671001588	dimerization interface [polypeptide binding]; other site
339671001589	ATP binding site [chemical binding]; other site
339671001590	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
339671001591	putative active site [active]
339671001592	catalytic triad [active]
339671001593	cytidine deaminase; Provisional; Region: PRK09027
339671001594	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
339671001595	active site
339671001596	catalytic motif [active]
339671001597	Zn binding site [ion binding]; other site
339671001598	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
339671001599	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
339671001600	uridine phosphorylase; Provisional; Region: PRK11178
339671001601	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
339671001602	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
339671001603	homotrimer interaction site [polypeptide binding]; other site
339671001604	putative active site [active]
339671001605	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
339671001606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671001607	S-adenosylmethionine binding site [chemical binding]; other site
339671001608	Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445
339671001609	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
339671001610	pseudouridine synthase; Region: TIGR00093
339671001611	active site
339671001612	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
339671001613	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
339671001614	Tannase and feruloyl esterase; Region: Tannase; pfam07519
339671001615	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515
339671001616	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
339671001617	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
339671001618	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
339671001619	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
339671001620	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
339671001621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
339671001622	NAD(P) binding site [chemical binding]; other site
339671001623	active site
339671001624	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
339671001625	active site
339671001626	intersubunit interactions; other site
339671001627	catalytic residue [active]
339671001628	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
339671001629	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
339671001630	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
339671001631	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
339671001632	selenocysteine synthase; Provisional; Region: PRK04311
339671001633	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
339671001634	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
339671001635	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
339671001636	catalytic residue [active]
339671001637	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
339671001638	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
339671001639	G1 box; other site
339671001640	putative GEF interaction site [polypeptide binding]; other site
339671001641	GTP/Mg2+ binding site [chemical binding]; other site
339671001642	Switch I region; other site
339671001643	G2 box; other site
339671001644	G3 box; other site
339671001645	Switch II region; other site
339671001646	G4 box; other site
339671001647	G5 box; other site
339671001648	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
339671001649	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
339671001650	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
339671001651	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
339671001652	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
339671001653	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
339671001654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671001655	S-adenosylmethionine binding site [chemical binding]; other site
339671001656	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
339671001657	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
339671001658	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
339671001659	P loop; other site
339671001660	GTP binding site [chemical binding]; other site
339671001661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
339671001662	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
339671001663	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
339671001664	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
339671001665	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
339671001666	DNA binding residues [nucleotide binding]
339671001667	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
339671001668	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
339671001669	FAD binding domain; Region: FAD_binding_4; pfam01565
339671001670	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
339671001671	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
339671001672	DinI-like family; Region: DinI; cl11630
339671001673	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
339671001674	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
339671001675	putative ion selectivity filter; other site
339671001676	putative pore gating glutamate residue; other site
339671001677	putative H+/Cl- coupling transport residue; other site
339671001678	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
339671001679	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
339671001680	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
339671001681	active site
339671001682	P-loop; other site
339671001683	phosphorylation site [posttranslational modification]
339671001684	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
339671001685	active site
339671001686	phosphorylation site [posttranslational modification]
339671001687	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
339671001688	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
339671001689	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
339671001690	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
339671001691	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
339671001692	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
339671001693	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
339671001694	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
339671001695	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
339671001696	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
339671001697	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
339671001698	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
339671001699	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
339671001700	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
339671001701	protein-rRNA interface [nucleotide binding]; other site
339671001702	putative translocon binding site; other site
339671001703	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
339671001704	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
339671001705	G-X-X-G motif; other site
339671001706	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
339671001707	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
339671001708	23S rRNA interface [nucleotide binding]; other site
339671001709	5S rRNA interface [nucleotide binding]; other site
339671001710	putative antibiotic binding site [chemical binding]; other site
339671001711	L25 interface [polypeptide binding]; other site
339671001712	L27 interface [polypeptide binding]; other site
339671001713	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
339671001714	23S rRNA interface [nucleotide binding]; other site
339671001715	putative translocon interaction site; other site
339671001716	signal recognition particle (SRP54) interaction site; other site
339671001717	L23 interface [polypeptide binding]; other site
339671001718	trigger factor interaction site; other site
339671001719	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
339671001720	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
339671001721	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
339671001722	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
339671001723	RNA binding site [nucleotide binding]; other site
339671001724	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
339671001725	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
339671001726	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
339671001727	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
339671001728	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
339671001729	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
339671001730	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
339671001731	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
339671001732	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
339671001733	5S rRNA interface [nucleotide binding]; other site
339671001734	L27 interface [polypeptide binding]; other site
339671001735	23S rRNA interface [nucleotide binding]; other site
339671001736	L5 interface [polypeptide binding]; other site
339671001737	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
339671001738	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
339671001739	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
339671001740	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
339671001741	23S rRNA binding site [nucleotide binding]; other site
339671001742	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
339671001743	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
339671001744	SecY translocase; Region: SecY; pfam00344
339671001745	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
339671001746	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
339671001747	30S ribosomal protein S13; Region: bact_S13; TIGR03631
339671001748	30S ribosomal protein S11; Validated; Region: PRK05309
339671001749	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
339671001750	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
339671001751	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
339671001752	RNA binding surface [nucleotide binding]; other site
339671001753	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
339671001754	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
339671001755	alphaNTD homodimer interface [polypeptide binding]; other site
339671001756	alphaNTD - beta interaction site [polypeptide binding]; other site
339671001757	alphaNTD - beta' interaction site [polypeptide binding]; other site
339671001758	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
339671001759	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
339671001760	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
339671001761	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
339671001762	active site
339671001763	metal binding site [ion binding]; metal-binding site
339671001764	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
339671001765	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
339671001766	non-specific DNA binding site [nucleotide binding]; other site
339671001767	salt bridge; other site
339671001768	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
339671001769	sequence-specific DNA binding site [nucleotide binding]; other site
339671001770	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
339671001771	active site
339671001772	(T/H)XGH motif; other site
339671001773	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
339671001774	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792
339671001775	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
339671001776	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
339671001777	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
339671001778	Walker A/P-loop; other site
339671001779	ATP binding site [chemical binding]; other site
339671001780	Q-loop/lid; other site
339671001781	ABC transporter signature motif; other site
339671001782	Walker B; other site
339671001783	D-loop; other site
339671001784	H-loop/switch region; other site
339671001785	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
339671001786	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
339671001787	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
339671001788	TM-ABC transporter signature motif; other site
339671001789	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
339671001790	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
339671001791	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
339671001792	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
339671001793	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
339671001794	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
339671001795	putative N- and C-terminal domain interface [polypeptide binding]; other site
339671001796	putative active site [active]
339671001797	MgATP binding site [chemical binding]; other site
339671001798	catalytic site [active]
339671001799	metal binding site [ion binding]; metal-binding site
339671001800	putative carbohydrate binding site [chemical binding]; other site
339671001801	L-arabinose isomerase; Provisional; Region: PRK02929
339671001802	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
339671001803	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
339671001804	trimer interface [polypeptide binding]; other site
339671001805	putative substrate binding site [chemical binding]; other site
339671001806	putative metal binding site [ion binding]; other site
339671001807	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
339671001808	putative dimerization interface [polypeptide binding]; other site
339671001809	putative ligand binding site [chemical binding]; other site
339671001810	Transcriptional regulators [Transcription]; Region: PurR; COG1609
339671001811	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
339671001812	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
339671001813	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
339671001814	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671001815	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671001816	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
339671001817	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
339671001818	TM-ABC transporter signature motif; other site
339671001819	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
339671001820	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671001821	Walker A/P-loop; other site
339671001822	ATP binding site [chemical binding]; other site
339671001823	Q-loop/lid; other site
339671001824	ABC transporter signature motif; other site
339671001825	Walker B; other site
339671001826	D-loop; other site
339671001827	H-loop/switch region; other site
339671001828	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
339671001829	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
339671001830	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
339671001831	putative ligand binding site [chemical binding]; other site
339671001832	xylose isomerase; Provisional; Region: PRK05474
339671001833	xylose isomerase; Region: xylose_isom_A; TIGR02630
339671001834	xylulokinase; Provisional; Region: PRK15027
339671001835	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
339671001836	N- and C-terminal domain interface [polypeptide binding]; other site
339671001837	active site
339671001838	MgATP binding site [chemical binding]; other site
339671001839	catalytic site [active]
339671001840	metal binding site [ion binding]; metal-binding site
339671001841	xylulose binding site [chemical binding]; other site
339671001842	homodimer interface [polypeptide binding]; other site
339671001843	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
339671001844	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
339671001845	FMN binding site [chemical binding]; other site
339671001846	active site
339671001847	catalytic residues [active]
339671001848	substrate binding site [chemical binding]; other site
339671001849	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
339671001850	dimer interface [polypeptide binding]; other site
339671001851	active site
339671001852	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
339671001853	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
339671001854	putative DNA binding site [nucleotide binding]; other site
339671001855	putative Zn2+ binding site [ion binding]; other site
339671001856	AsnC family; Region: AsnC_trans_reg; pfam01037
339671001857	Mg chelatase-related protein; Region: TIGR00368
339671001858	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
339671001859	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671001860	Walker A motif; other site
339671001861	ATP binding site [chemical binding]; other site
339671001862	Walker B motif; other site
339671001863	arginine finger; other site
339671001864	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
339671001865	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
339671001866	G1 box; other site
339671001867	GTP/Mg2+ binding site [chemical binding]; other site
339671001868	Switch I region; other site
339671001869	G2 box; other site
339671001870	G3 box; other site
339671001871	Switch II region; other site
339671001872	G4 box; other site
339671001873	G5 box; other site
339671001874	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
339671001875	Predicted membrane protein [Function unknown]; Region: COG4125
339671001876	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
339671001877	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
339671001878	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
339671001879	active site
339671001880	P-loop; other site
339671001881	phosphorylation site [posttranslational modification]
339671001882	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
339671001883	CPxP  motif; other site
339671001884	hypothetical protein; Provisional; Region: PRK11568
339671001885	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
339671001886	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
339671001887	Cation transport protein; Region: TrkH; cl17365
339671001888	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
339671001889	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
339671001890	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
339671001891	homodimer interaction site [polypeptide binding]; other site
339671001892	cofactor binding site; other site
339671001893	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
339671001894	UbiA prenyltransferase family; Region: UbiA; pfam01040
339671001895	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
339671001896	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
339671001897	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
339671001898	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
339671001899	RimM N-terminal domain; Region: RimM; pfam01782
339671001900	PRC-barrel domain; Region: PRC; pfam05239
339671001901	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
339671001902	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
339671001903	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
339671001904	putative metal binding site; other site
339671001905	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
339671001906	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
339671001907	Substrate binding site; other site
339671001908	metal-binding site
339671001909	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
339671001910	dimer interface [polypeptide binding]; other site
339671001911	substrate binding site [chemical binding]; other site
339671001912	metal binding sites [ion binding]; metal-binding site
339671001913	Peptidase family M48; Region: Peptidase_M48; pfam01435
339671001914	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
339671001915	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
339671001916	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
339671001917	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
339671001918	primosome assembly protein PriA; Validated; Region: PRK05580
339671001919	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
339671001920	ATP binding site [chemical binding]; other site
339671001921	putative Mg++ binding site [ion binding]; other site
339671001922	DAN domain; Region: DAN; cl17734
339671001923	helicase superfamily c-terminal domain; Region: HELICc; smart00490
339671001924	nucleotide binding region [chemical binding]; other site
339671001925	ATP-binding site [chemical binding]; other site
339671001926	Sporulation related domain; Region: SPOR; cl10051
339671001927	Sporulation related domain; Region: SPOR; pfam05036
339671001928	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
339671001929	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
339671001930	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
339671001931	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
339671001932	HlyD family secretion protein; Region: HlyD_3; pfam13437
339671001933	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
339671001934	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
339671001935	dimer interface [polypeptide binding]; other site
339671001936	active site
339671001937	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
339671001938	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
339671001939	CAS motifs; other site
339671001940	active site
339671001941	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
339671001942	Phosphoglycerate kinase; Region: PGK; pfam00162
339671001943	substrate binding site [chemical binding]; other site
339671001944	hinge regions; other site
339671001945	ADP binding site [chemical binding]; other site
339671001946	catalytic site [active]
339671001947	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
339671001948	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
339671001949	active site
339671001950	intersubunit interface [polypeptide binding]; other site
339671001951	zinc binding site [ion binding]; other site
339671001952	Na+ binding site [ion binding]; other site
339671001953	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
339671001954	O-Antigen ligase; Region: Wzy_C; pfam04932
339671001955	hypothetical protein; Provisional; Region: PRK11702
339671001956	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
339671001957	adenine DNA glycosylase; Provisional; Region: PRK10880
339671001958	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
339671001959	minor groove reading motif; other site
339671001960	helix-hairpin-helix signature motif; other site
339671001961	substrate binding pocket [chemical binding]; other site
339671001962	active site
339671001963	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
339671001964	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
339671001965	DNA binding and oxoG recognition site [nucleotide binding]
339671001966	oxidative damage protection protein; Provisional; Region: PRK05408
339671001967	murein transglycosylase C; Provisional; Region: mltC; PRK11671
339671001968	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
339671001969	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
339671001970	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
339671001971	N-acetyl-D-glucosamine binding site [chemical binding]; other site
339671001972	catalytic residue [active]
339671001973	hypothetical protein; Validated; Region: PRK05445
339671001974	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
339671001975	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
339671001976	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
339671001977	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
339671001978	catalytic site [active]
339671001979	subunit interface [polypeptide binding]; other site
339671001980	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
339671001981	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
339671001982	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
339671001983	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
339671001984	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
339671001985	ATP-grasp domain; Region: ATP-grasp_4; cl17255
339671001986	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
339671001987	IMP binding site; other site
339671001988	dimer interface [polypeptide binding]; other site
339671001989	interdomain contacts; other site
339671001990	partial ornithine binding site; other site
339671001991	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
339671001992	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
339671001993	Substrate binding site; other site
339671001994	Mg++ binding site; other site
339671001995	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
339671001996	active site
339671001997	substrate binding site [chemical binding]; other site
339671001998	CoA binding site [chemical binding]; other site
339671001999	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
339671002000	putative oxidoreductase; Provisional; Region: PRK11579
339671002001	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
339671002002	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
339671002003	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
339671002004	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
339671002005	putative C-terminal domain interface [polypeptide binding]; other site
339671002006	putative GSH binding site (G-site) [chemical binding]; other site
339671002007	putative dimer interface [polypeptide binding]; other site
339671002008	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
339671002009	N-terminal domain interface [polypeptide binding]; other site
339671002010	dimer interface [polypeptide binding]; other site
339671002011	substrate binding pocket (H-site) [chemical binding]; other site
339671002012	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
339671002013	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
339671002014	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
339671002015	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
339671002016	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
339671002017	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
339671002018	putative active site [active]
339671002019	putative FMN binding site [chemical binding]; other site
339671002020	putative substrate binding site [chemical binding]; other site
339671002021	putative catalytic residue [active]
339671002022	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
339671002023	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
339671002024	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
339671002025	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
339671002026	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
339671002027	HIGH motif; other site
339671002028	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
339671002029	active site
339671002030	KMSKS motif; other site
339671002031	Sulfatase; Region: Sulfatase; cl17466
339671002032	transcription-repair coupling factor; Provisional; Region: PRK10689
339671002033	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
339671002034	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
339671002035	ATP binding site [chemical binding]; other site
339671002036	putative Mg++ binding site [ion binding]; other site
339671002037	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
339671002038	nucleotide binding region [chemical binding]; other site
339671002039	ATP-binding site [chemical binding]; other site
339671002040	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
339671002041	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
339671002042	30S subunit binding site; other site
339671002043	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
339671002044	Peptidase family M23; Region: Peptidase_M23; pfam01551
339671002045	Predicted membrane protein [Function unknown]; Region: COG1238
339671002046	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
339671002047	ketol-acid reductoisomerase; Validated; Region: PRK05225
339671002048	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
339671002049	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
339671002050	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
339671002051	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
339671002052	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
339671002053	putative metal binding site [ion binding]; other site
339671002054	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671002055	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
339671002056	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
339671002057	dimerization interface [polypeptide binding]; other site
339671002058	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
339671002059	DNA protecting protein DprA; Region: dprA; TIGR00732
339671002060	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
339671002061	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671002062	FeS/SAM binding site; other site
339671002063	Protein of unknown function (DUF533); Region: DUF533; pfam04391
339671002064	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
339671002065	putative metal binding site [ion binding]; other site
339671002066	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
339671002067	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
339671002068	NodB motif; other site
339671002069	putative active site [active]
339671002070	putative catalytic site [active]
339671002071	Zn binding site [ion binding]; other site
339671002072	AmiB activator; Provisional; Region: PRK11637
339671002073	Peptidase family M23; Region: Peptidase_M23; pfam01551
339671002074	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
339671002075	catalytic core [active]
339671002076	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
339671002077	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
339671002078	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
339671002079	putative active site [active]
339671002080	hypothetical protein; Validated; Region: PRK02101
339671002081	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
339671002082	ligand binding site [chemical binding]; other site
339671002083	active site
339671002084	UGI interface [polypeptide binding]; other site
339671002085	catalytic site [active]
339671002086	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
339671002087	GTP-binding protein LepA; Provisional; Region: PRK05433
339671002088	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
339671002089	G1 box; other site
339671002090	putative GEF interaction site [polypeptide binding]; other site
339671002091	GTP/Mg2+ binding site [chemical binding]; other site
339671002092	Switch I region; other site
339671002093	G2 box; other site
339671002094	G3 box; other site
339671002095	Switch II region; other site
339671002096	G4 box; other site
339671002097	G5 box; other site
339671002098	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
339671002099	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
339671002100	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
339671002101	signal peptidase I; Provisional; Region: PRK10861
339671002102	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
339671002103	Catalytic site [active]
339671002104	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
339671002105	Catalytic site [active]
339671002106	ribonuclease III; Reviewed; Region: rnc; PRK00102
339671002107	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
339671002108	dimerization interface [polypeptide binding]; other site
339671002109	active site
339671002110	metal binding site [ion binding]; metal-binding site
339671002111	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
339671002112	dsRNA binding site [nucleotide binding]; other site
339671002113	GTPase Era; Reviewed; Region: era; PRK00089
339671002114	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
339671002115	G1 box; other site
339671002116	GTP/Mg2+ binding site [chemical binding]; other site
339671002117	Switch I region; other site
339671002118	G2 box; other site
339671002119	Switch II region; other site
339671002120	G3 box; other site
339671002121	G4 box; other site
339671002122	G5 box; other site
339671002123	KH domain; Region: KH_2; pfam07650
339671002124	transaldolase-like protein; Provisional; Region: PTZ00411
339671002125	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
339671002126	active site
339671002127	dimer interface [polypeptide binding]; other site
339671002128	catalytic residue [active]
339671002129	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
339671002130	HTH domain; Region: HTH_11; pfam08279
339671002131	HTH domain; Region: HTH_11; cl17392
339671002132	PRD domain; Region: PRD; pfam00874
339671002133	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
339671002134	active site
339671002135	P-loop; other site
339671002136	phosphorylation site [posttranslational modification]
339671002137	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
339671002138	active site
339671002139	phosphorylation site [posttranslational modification]
339671002140	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
339671002141	active site
339671002142	phosphorylation site [posttranslational modification]
339671002143	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
339671002144	active site
339671002145	P-loop; other site
339671002146	phosphorylation site [posttranslational modification]
339671002147	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
339671002148	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
339671002149	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
339671002150	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
339671002151	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
339671002152	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
339671002153	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
339671002154	RNA binding site [nucleotide binding]; other site
339671002155	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
339671002156	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
339671002157	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
339671002158	putative catalytic cysteine [active]
339671002159	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
339671002160	putative active site [active]
339671002161	metal binding site [ion binding]; metal-binding site
339671002162	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
339671002163	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
339671002164	active site
339671002165	catalytic site [active]
339671002166	metal binding site [ion binding]; metal-binding site
339671002167	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
339671002168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671002169	putative substrate translocation pore; other site
339671002170	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
339671002171	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
339671002172	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671002173	Walker A/P-loop; other site
339671002174	ATP binding site [chemical binding]; other site
339671002175	Q-loop/lid; other site
339671002176	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
339671002177	ABC transporter; Region: ABC_tran_2; pfam12848
339671002178	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
339671002179	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
339671002180	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
339671002181	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
339671002182	BolA-like protein; Region: BolA; cl00386
339671002183	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
339671002184	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
339671002185	E3 interaction surface; other site
339671002186	lipoyl attachment site [posttranslational modification]; other site
339671002187	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
339671002188	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
339671002189	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
339671002190	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
339671002191	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
339671002192	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
339671002193	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
339671002194	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
339671002195	FAD binding pocket [chemical binding]; other site
339671002196	FAD binding motif [chemical binding]; other site
339671002197	phosphate binding motif [ion binding]; other site
339671002198	beta-alpha-beta structure motif; other site
339671002199	NAD binding pocket [chemical binding]; other site
339671002200	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
339671002201	ApbE family; Region: ApbE; pfam02424
339671002202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
339671002203	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
339671002204	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
339671002205	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
339671002206	Coenzyme A binding pocket [chemical binding]; other site
339671002207	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
339671002208	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
339671002209	CoA-binding site [chemical binding]; other site
339671002210	ATP-binding [chemical binding]; other site
339671002211	DNA gyrase inhibitor; Reviewed; Region: PRK00418
339671002212	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
339671002213	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
339671002214	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
339671002215	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
339671002216	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
339671002217	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
339671002218	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
339671002219	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
339671002220	Walker A motif; other site
339671002221	ATP binding site [chemical binding]; other site
339671002222	Walker B motif; other site
339671002223	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
339671002224	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
339671002225	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
339671002226	amidase catalytic site [active]
339671002227	substrate binding site [chemical binding]; other site
339671002228	Zn binding residues [ion binding]; other site
339671002229	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
339671002230	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671002231	motif II; other site
339671002232	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671002233	dimer interface [polypeptide binding]; other site
339671002234	conserved gate region; other site
339671002235	putative PBP binding loops; other site
339671002236	ABC-ATPase subunit interface; other site
339671002237	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
339671002238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671002239	dimer interface [polypeptide binding]; other site
339671002240	conserved gate region; other site
339671002241	putative PBP binding loops; other site
339671002242	ABC-ATPase subunit interface; other site
339671002243	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
339671002244	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
339671002245	substrate binding pocket [chemical binding]; other site
339671002246	membrane-bound complex binding site; other site
339671002247	hinge residues; other site
339671002248	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
339671002249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671002250	Walker A/P-loop; other site
339671002251	ATP binding site [chemical binding]; other site
339671002252	Q-loop/lid; other site
339671002253	ABC transporter signature motif; other site
339671002254	Walker B; other site
339671002255	D-loop; other site
339671002256	H-loop/switch region; other site
339671002257	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
339671002258	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
339671002259	FMN binding site [chemical binding]; other site
339671002260	active site
339671002261	catalytic residues [active]
339671002262	substrate binding site [chemical binding]; other site
339671002263	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
339671002264	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
339671002265	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
339671002266	putative metal binding site [ion binding]; other site
339671002267	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
339671002268	HSP70 interaction site [polypeptide binding]; other site
339671002269	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
339671002270	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
339671002271	phosphopentomutase; Provisional; Region: PRK05362
339671002272	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
339671002273	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
339671002274	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
339671002275	Nucleoside recognition; Region: Gate; pfam07670
339671002276	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
339671002277	Predicted membrane protein [Function unknown]; Region: COG2364
339671002278	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
339671002279	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
339671002280	aromatic amino acid transport protein; Region: araaP; TIGR00837
339671002281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
339671002282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671002283	S-adenosylmethionine binding site [chemical binding]; other site
339671002284	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
339671002285	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
339671002286	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
339671002287	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
339671002288	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
339671002289	NAD binding site [chemical binding]; other site
339671002290	dimerization interface [polypeptide binding]; other site
339671002291	product binding site; other site
339671002292	substrate binding site [chemical binding]; other site
339671002293	zinc binding site [ion binding]; other site
339671002294	catalytic residues [active]
339671002295	LysE type translocator; Region: LysE; cl00565
339671002296	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
339671002297	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
339671002298	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671002299	homodimer interface [polypeptide binding]; other site
339671002300	catalytic residue [active]
339671002301	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
339671002302	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671002303	active site
339671002304	motif I; other site
339671002305	motif II; other site
339671002306	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
339671002307	putative active site pocket [active]
339671002308	4-fold oligomerization interface [polypeptide binding]; other site
339671002309	metal binding residues [ion binding]; metal-binding site
339671002310	3-fold/trimer interface [polypeptide binding]; other site
339671002311	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
339671002312	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
339671002313	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
339671002314	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
339671002315	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
339671002316	active site
339671002317	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
339671002318	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
339671002319	homodimer interface [polypeptide binding]; other site
339671002320	NAD binding pocket [chemical binding]; other site
339671002321	ATP binding pocket [chemical binding]; other site
339671002322	Mg binding site [ion binding]; other site
339671002323	active-site loop [active]
339671002324	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
339671002325	Dehydroquinase class II; Region: DHquinase_II; pfam01220
339671002326	active site
339671002327	trimer interface [polypeptide binding]; other site
339671002328	dimer interface [polypeptide binding]; other site
339671002329	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
339671002330	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
339671002331	carboxyltransferase (CT) interaction site; other site
339671002332	biotinylation site [posttranslational modification]; other site
339671002333	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
339671002334	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
339671002335	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
339671002336	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
339671002337	Predicted membrane protein [Function unknown]; Region: COG3924
339671002338	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
339671002339	Na binding site [ion binding]; other site
339671002340	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
339671002341	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
339671002342	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
339671002343	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
339671002344	FMN binding site [chemical binding]; other site
339671002345	active site
339671002346	catalytic residues [active]
339671002347	substrate binding site [chemical binding]; other site
339671002348	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
339671002349	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
339671002350	O-succinylbenzoate synthase; Provisional; Region: PRK05105
339671002351	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
339671002352	active site
339671002353	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
339671002354	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
339671002355	substrate binding site [chemical binding]; other site
339671002356	oxyanion hole (OAH) forming residues; other site
339671002357	trimer interface [polypeptide binding]; other site
339671002358	Uncharacterized conserved protein [Function unknown]; Region: COG2128
339671002359	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
339671002360	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
339671002361	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
339671002362	Sulfatase; Region: Sulfatase; pfam00884
339671002363	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
339671002364	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
339671002365	tetramer interface [polypeptide binding]; other site
339671002366	heme binding pocket [chemical binding]; other site
339671002367	NADPH binding site [chemical binding]; other site
339671002368	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
339671002369	putative nucleotide binding site [chemical binding]; other site
339671002370	uridine monophosphate binding site [chemical binding]; other site
339671002371	homohexameric interface [polypeptide binding]; other site
339671002372	ribosome recycling factor; Reviewed; Region: frr; PRK00083
339671002373	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
339671002374	hinge region; other site
339671002375	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
339671002376	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
339671002377	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
339671002378	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
339671002379	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
339671002380	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
339671002381	Cell division protein ZapA; Region: ZapA; pfam05164
339671002382	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
339671002383	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
339671002384	proline aminopeptidase P II; Provisional; Region: PRK10879
339671002385	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
339671002386	active site
339671002387	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
339671002388	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
339671002389	ring oligomerisation interface [polypeptide binding]; other site
339671002390	ATP/Mg binding site [chemical binding]; other site
339671002391	stacking interactions; other site
339671002392	hinge regions; other site
339671002393	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
339671002394	oligomerisation interface [polypeptide binding]; other site
339671002395	mobile loop; other site
339671002396	roof hairpin; other site
339671002397	twin arginine translocase protein A; Provisional; Region: tatA; PRK01833
339671002398	sec-independent translocase; Provisional; Region: PRK01770
339671002399	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
339671002400	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
339671002401	dimer interface [polypeptide binding]; other site
339671002402	allosteric magnesium binding site [ion binding]; other site
339671002403	active site
339671002404	aspartate-rich active site metal binding site; other site
339671002405	Schiff base residues; other site
339671002406	superoxide dismutase; Provisional; Region: PRK10925
339671002407	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
339671002408	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
339671002409	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
339671002410	Malic enzyme, N-terminal domain; Region: malic; pfam00390
339671002411	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
339671002412	putative NAD(P) binding site [chemical binding]; other site
339671002413	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
339671002414	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
339671002415	RNA binding surface [nucleotide binding]; other site
339671002416	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
339671002417	active site
339671002418	uracil binding [chemical binding]; other site
339671002419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671002420	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
339671002421	putative substrate translocation pore; other site
339671002422	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
339671002423	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
339671002424	DNA methylase; Region: N6_N4_Mtase; pfam01555
339671002425	Restriction endonuclease [Defense mechanisms]; Region: COG3587
339671002426	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
339671002427	ATP binding site [chemical binding]; other site
339671002428	putative Mg++ binding site [ion binding]; other site
339671002429	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
339671002430	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
339671002431	active site
339671002432	(T/H)XGH motif; other site
339671002433	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
339671002434	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
339671002435	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
339671002436	triosephosphate isomerase; Provisional; Region: PRK14567
339671002437	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
339671002438	substrate binding site [chemical binding]; other site
339671002439	dimer interface [polypeptide binding]; other site
339671002440	catalytic triad [active]
339671002441	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
339671002442	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
339671002443	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
339671002444	hypothetical protein; Provisional; Region: PRK02119
339671002445	Protein of unknown function (DUF1375); Region: DUF1375; pfam07119
339671002446	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
339671002447	Part of AAA domain; Region: AAA_19; pfam13245
339671002448	Family description; Region: UvrD_C_2; pfam13538
339671002449	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
339671002450	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671002451	active site
339671002452	motif I; other site
339671002453	motif II; other site
339671002454	maltose O-acetyltransferase; Provisional; Region: PRK10092
339671002455	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
339671002456	active site
339671002457	substrate binding site [chemical binding]; other site
339671002458	trimer interface [polypeptide binding]; other site
339671002459	CoA binding site [chemical binding]; other site
339671002460	S-ribosylhomocysteinase; Provisional; Region: PRK02260
339671002461	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
339671002462	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
339671002463	ATP-grasp domain; Region: ATP-grasp; pfam02222
339671002464	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
339671002465	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
339671002466	active site
339671002467	ADP/pyrophosphate binding site [chemical binding]; other site
339671002468	dimerization interface [polypeptide binding]; other site
339671002469	allosteric effector site; other site
339671002470	fructose-1,6-bisphosphate binding site; other site
339671002471	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
339671002472	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
339671002473	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
339671002474	Pilus assembly protein, PilP; Region: PilP; pfam04351
339671002475	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
339671002476	Competence protein A; Region: Competence_A; pfam11104
339671002477	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
339671002478	Transglycosylase; Region: Transgly; pfam00912
339671002479	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
339671002480	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
339671002481	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
339671002482	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
339671002483	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
339671002484	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
339671002485	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
339671002486	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
339671002487	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
339671002488	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
339671002489	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
339671002490	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
339671002491	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
339671002492	hypothetical protein; Provisional; Region: PRK04998
339671002493	lipoate-protein ligase B; Provisional; Region: PRK14342
339671002494	lipoyl synthase; Provisional; Region: PRK05481
339671002495	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671002496	FeS/SAM binding site; other site
339671002497	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
339671002498	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
339671002499	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
339671002500	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
339671002501	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
339671002502	cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145
339671002503	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
339671002504	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
339671002505	catalytic residues [active]
339671002506	central insert; other site
339671002507	cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147
339671002508	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
339671002509	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
339671002510	binding surface
339671002511	Predicted flavoproteins [General function prediction only]; Region: COG2081
339671002512	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
339671002513	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
339671002514	substrate binding site [chemical binding]; other site
339671002515	THF binding site; other site
339671002516	zinc-binding site [ion binding]; other site
339671002517	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
339671002518	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
339671002519	folate binding site [chemical binding]; other site
339671002520	NADP+ binding site [chemical binding]; other site
339671002521	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
339671002522	Uncharacterized conserved protein [Function unknown]; Region: COG2966
339671002523	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
339671002524	gamma-glutamyl kinase; Provisional; Region: PRK05429
339671002525	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
339671002526	nucleotide binding site [chemical binding]; other site
339671002527	homotetrameric interface [polypeptide binding]; other site
339671002528	putative phosphate binding site [ion binding]; other site
339671002529	putative allosteric binding site; other site
339671002530	PUA domain; Region: PUA; pfam01472
339671002531	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
339671002532	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
339671002533	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
339671002534	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
339671002535	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
339671002536	DNA primase; Validated; Region: dnaG; PRK05667
339671002537	CHC2 zinc finger; Region: zf-CHC2; pfam01807
339671002538	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
339671002539	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
339671002540	active site
339671002541	metal binding site [ion binding]; metal-binding site
339671002542	interdomain interaction site; other site
339671002543	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
339671002544	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
339671002545	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
339671002546	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
339671002547	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
339671002548	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
339671002549	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
339671002550	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
339671002551	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
339671002552	DNA binding residues [nucleotide binding]
339671002553	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
339671002554	nucleoside/Zn binding site; other site
339671002555	dimer interface [polypeptide binding]; other site
339671002556	catalytic motif [active]
339671002557	thymidylate synthase; Reviewed; Region: thyA; PRK01827
339671002558	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
339671002559	dimerization interface [polypeptide binding]; other site
339671002560	active site
339671002561	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
339671002562	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
339671002563	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
339671002564	putative active site [active]
339671002565	Ap4A binding site [chemical binding]; other site
339671002566	nudix motif; other site
339671002567	putative metal binding site [ion binding]; other site
339671002568	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
339671002569	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
339671002570	dimerization interface [polypeptide binding]; other site
339671002571	putative ATP binding site [chemical binding]; other site
339671002572	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
339671002573	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
339671002574	active site
339671002575	substrate binding site [chemical binding]; other site
339671002576	cosubstrate binding site; other site
339671002577	catalytic site [active]
339671002578	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
339671002579	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
339671002580	active site
339671002581	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
339671002582	SurA N-terminal domain; Region: SurA_N; pfam09312
339671002583	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
339671002584	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
339671002585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671002586	S-adenosylmethionine binding site [chemical binding]; other site
339671002587	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
339671002588	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
339671002589	active site
339671002590	metal binding site [ion binding]; metal-binding site
339671002591	Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786
339671002592	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
339671002593	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
339671002594	MerT mercuric transport protein; Region: MerT; cl03578
339671002595	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
339671002596	metal-binding site [ion binding]
339671002597	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
339671002598	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
339671002599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
339671002600	Coenzyme A binding pocket [chemical binding]; other site
339671002601	Transcriptional regulators [Transcription]; Region: MarR; COG1846
339671002602	MarR family; Region: MarR_2; pfam12802
339671002603	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
339671002604	Acyltransferase family; Region: Acyl_transf_3; pfam01757
339671002605	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
339671002606	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
339671002607	HIGH motif; other site
339671002608	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
339671002609	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
339671002610	active site
339671002611	KMSKS motif; other site
339671002612	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
339671002613	tRNA binding surface [nucleotide binding]; other site
339671002614	Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980
339671002615	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
339671002616	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
339671002617	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
339671002618	amino acid carrier protein; Region: agcS; TIGR00835
339671002619	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
339671002620	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
339671002621	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
339671002622	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
339671002623	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
339671002624	glutaminase active site [active]
339671002625	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
339671002626	dimer interface [polypeptide binding]; other site
339671002627	active site
339671002628	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
339671002629	dimer interface [polypeptide binding]; other site
339671002630	active site
339671002631	benzoate transport; Region: 2A0115; TIGR00895
339671002632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671002633	putative substrate translocation pore; other site
339671002634	hypothetical protein; Provisional; Region: PRK11573
339671002635	Domain of unknown function DUF21; Region: DUF21; pfam01595
339671002636	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
339671002637	Transporter associated domain; Region: CorC_HlyC; smart01091
339671002638	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
339671002639	signal recognition particle protein; Provisional; Region: PRK10867
339671002640	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
339671002641	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
339671002642	P loop; other site
339671002643	GTP binding site [chemical binding]; other site
339671002644	Signal peptide binding domain; Region: SRP_SPB; pfam02978
339671002645	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
339671002646	YheO-like PAS domain; Region: PAS_6; pfam08348
339671002647	HTH domain; Region: HTH_22; pfam13309
339671002648	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
339671002649	sulfur relay protein TusC; Validated; Region: PRK00211
339671002650	Uncharacterized conserved protein involved in oxidation of intracellular sulfur [Inorganic ion transport and metabolism]; Region: DsrH; COG2168
339671002651	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
339671002652	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
339671002653	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
339671002654	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
339671002655	primosomal replication protein N; Provisional; Region: PRK02801
339671002656	generic binding surface I; other site
339671002657	generic binding surface II; other site
339671002658	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
339671002659	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
339671002660	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
339671002661	substrate binding pocket [chemical binding]; other site
339671002662	membrane-bound complex binding site; other site
339671002663	hinge residues; other site
339671002664	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
339671002665	N-acetyl-D-glucosamine binding site [chemical binding]; other site
339671002666	catalytic residue [active]
339671002667	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
339671002668	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
339671002669	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
339671002670	homodimer interface [polypeptide binding]; other site
339671002671	NADP binding site [chemical binding]; other site
339671002672	substrate binding site [chemical binding]; other site
339671002673	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
339671002674	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
339671002675	trigger factor; Provisional; Region: tig; PRK01490
339671002676	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
339671002677	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
339671002678	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
339671002679	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
339671002680	oligomer interface [polypeptide binding]; other site
339671002681	active site residues [active]
339671002682	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
339671002683	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
339671002684	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
339671002685	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671002686	Walker A motif; other site
339671002687	ATP binding site [chemical binding]; other site
339671002688	Walker B motif; other site
339671002689	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
339671002690	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
339671002691	Found in ATP-dependent protease La (LON); Region: LON; smart00464
339671002692	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671002693	Walker A motif; other site
339671002694	ATP binding site [chemical binding]; other site
339671002695	Walker B motif; other site
339671002696	arginine finger; other site
339671002697	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
339671002698	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
339671002699	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
339671002700	periplasmic folding chaperone; Provisional; Region: PRK10788
339671002701	SurA N-terminal domain; Region: SurA_N_3; cl07813
339671002702	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
339671002703	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
339671002704	trimer interface [polypeptide binding]; other site
339671002705	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
339671002706	trimer interface [polypeptide binding]; other site
339671002707	Haemagglutinin; Region: HIM; pfam05662
339671002708	YadA-like C-terminal region; Region: YadA; pfam03895
339671002709	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
339671002710	rRNA interaction site [nucleotide binding]; other site
339671002711	S8 interaction site; other site
339671002712	putative laminin-1 binding site; other site
339671002713	elongation factor Ts; Provisional; Region: tsf; PRK09377
339671002714	UBA/TS-N domain; Region: UBA; pfam00627
339671002715	Elongation factor TS; Region: EF_TS; pfam00889
339671002716	Elongation factor TS; Region: EF_TS; pfam00889
339671002717	hypothetical protein; Validated; Region: PRK06886
339671002718	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
339671002719	active site
339671002720	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
339671002721	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
339671002722	Sulfatase; Region: Sulfatase; cl17466
339671002723	hypothetical protein; Provisional; Region: PRK13689
339671002724	Nucleoid-associated protein [General function prediction only]; Region: COG3081
339671002725	nucleoid-associated protein NdpA; Validated; Region: PRK00378
339671002726	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
339671002727	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
339671002728	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
339671002729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
339671002730	active site
339671002731	phosphorylation site [posttranslational modification]
339671002732	intermolecular recognition site; other site
339671002733	dimerization interface [polypeptide binding]; other site
339671002734	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
339671002735	DNA binding site [nucleotide binding]
339671002736	two-component sensor protein; Provisional; Region: cpxA; PRK09470
339671002737	HAMP domain; Region: HAMP; pfam00672
339671002738	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
339671002739	dimer interface [polypeptide binding]; other site
339671002740	phosphorylation site [posttranslational modification]
339671002741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
339671002742	ATP binding site [chemical binding]; other site
339671002743	Mg2+ binding site [ion binding]; other site
339671002744	G-X-G motif; other site
339671002745	aminotransferase AlaT; Validated; Region: PRK09265
339671002746	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
339671002747	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671002748	homodimer interface [polypeptide binding]; other site
339671002749	catalytic residue [active]
339671002750	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
339671002751	chorismate binding enzyme; Region: Chorismate_bind; cl10555
339671002752	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
339671002753	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
339671002754	dimer interface [polypeptide binding]; other site
339671002755	tetramer interface [polypeptide binding]; other site
339671002756	PYR/PP interface [polypeptide binding]; other site
339671002757	TPP binding site [chemical binding]; other site
339671002758	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
339671002759	TPP-binding site; other site
339671002760	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
339671002761	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
339671002762	Walker A/P-loop; other site
339671002763	ATP binding site [chemical binding]; other site
339671002764	Q-loop/lid; other site
339671002765	ABC transporter signature motif; other site
339671002766	Walker B; other site
339671002767	D-loop; other site
339671002768	H-loop/switch region; other site
339671002769	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
339671002770	conserved hypothetical integral membrane protein; Region: TIGR00056
339671002771	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
339671002772	mce related protein; Region: MCE; pfam02470
339671002773	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
339671002774	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
339671002775	anti sigma factor interaction site; other site
339671002776	regulatory phosphorylation site [posttranslational modification]; other site
339671002777	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
339671002778	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
339671002779	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
339671002780	hinge; other site
339671002781	active site
339671002782	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
339671002783	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
339671002784	Walker A/P-loop; other site
339671002785	ATP binding site [chemical binding]; other site
339671002786	Q-loop/lid; other site
339671002787	ABC transporter signature motif; other site
339671002788	Walker B; other site
339671002789	D-loop; other site
339671002790	H-loop/switch region; other site
339671002791	Cobalt transport protein; Region: CbiQ; cl00463
339671002792	cobalt transport protein CbiM; Validated; Region: PRK06265
339671002793	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
339671002794	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
339671002795	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
339671002796	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
339671002797	DNA binding residues [nucleotide binding]
339671002798	dimer interface [polypeptide binding]; other site
339671002799	putative metal binding site [ion binding]; other site
339671002800	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
339671002801	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
339671002802	catalytic residue [active]
339671002803	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
339671002804	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
339671002805	E-class dimer interface [polypeptide binding]; other site
339671002806	P-class dimer interface [polypeptide binding]; other site
339671002807	active site
339671002808	Cu2+ binding site [ion binding]; other site
339671002809	Zn2+ binding site [ion binding]; other site
339671002810	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
339671002811	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
339671002812	nucleotide binding site [chemical binding]; other site
339671002813	substrate binding site [chemical binding]; other site
339671002814	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
339671002815	dimer interface [polypeptide binding]; other site
339671002816	putative threonine allosteric regulatory site; other site
339671002817	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
339671002818	putative threonine allosteric regulatory site; other site
339671002819	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
339671002820	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
339671002821	homoserine kinase; Provisional; Region: PRK01212
339671002822	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
339671002823	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
339671002824	threonine synthase; Validated; Region: PRK09225
339671002825	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
339671002826	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
339671002827	catalytic residue [active]
339671002828	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
339671002829	CHAP domain; Region: CHAP; pfam05257
339671002830	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
339671002831	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
339671002832	ArsC family; Region: ArsC; pfam03960
339671002833	putative catalytic residues [active]
339671002834	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
339671002835	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
339671002836	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
339671002837	metal binding site [ion binding]; metal-binding site
339671002838	dimer interface [polypeptide binding]; other site
339671002839	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
339671002840	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
339671002841	hypothetical protein; Provisional; Region: PRK05255
339671002842	peptidase PmbA; Provisional; Region: PRK11040
339671002843	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
339671002844	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
339671002845	active site
339671002846	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
339671002847	Divergent AAA domain; Region: AAA_4; pfam04326
339671002848	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
339671002849	chain length determinant protein WzzB; Provisional; Region: PRK15471
339671002850	Chain length determinant protein; Region: Wzz; cl15801
339671002851	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
339671002852	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
339671002853	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
339671002854	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
339671002855	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
339671002856	active site
339671002857	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
339671002858	Protein of unknown function DUF262; Region: DUF262; pfam03235
339671002859	Uncharacterized conserved protein [Function unknown]; Region: COG1479
339671002860	Protein of unknown function DUF262; Region: DUF262; pfam03235
339671002861	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
339671002862	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
339671002863	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
339671002864	UDP-galactopyranose mutase; Region: GLF; pfam03275
339671002865	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
339671002866	Bacterial sugar transferase; Region: Bac_transf; pfam02397
339671002867	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
339671002868	Acyltransferase family; Region: Acyl_transf_3; pfam01757
339671002869	Fic family protein [Function unknown]; Region: COG3177
339671002870	Fic/DOC family; Region: Fic; pfam02661
339671002871	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
339671002872	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
339671002873	NAD binding site [chemical binding]; other site
339671002874	substrate binding site [chemical binding]; other site
339671002875	homodimer interface [polypeptide binding]; other site
339671002876	active site
339671002877	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
339671002878	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
339671002879	active site
339671002880	NTP binding site [chemical binding]; other site
339671002881	metal binding triad [ion binding]; metal-binding site
339671002882	antibiotic binding site [chemical binding]; other site
339671002883	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
339671002884	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
339671002885	substrate binding site; other site
339671002886	tetramer interface; other site
339671002887	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
339671002888	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
339671002889	NADP binding site [chemical binding]; other site
339671002890	active site
339671002891	putative substrate binding site [chemical binding]; other site
339671002892	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
339671002893	metal binding triad [ion binding]; metal-binding site
339671002894	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
339671002895	aminopeptidase B; Provisional; Region: PRK05015
339671002896	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
339671002897	interface (dimer of trimers) [polypeptide binding]; other site
339671002898	Substrate-binding/catalytic site; other site
339671002899	Zn-binding sites [ion binding]; other site
339671002900	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
339671002901	active site
339671002902	multimer interface [polypeptide binding]; other site
339671002903	S-adenosylmethionine synthetase; Validated; Region: PRK05250
339671002904	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
339671002905	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
339671002906	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
339671002907	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
339671002908	hypothetical protein; Provisional; Region: PRK04860
339671002909	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
339671002910	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
339671002911	heat shock protein 90; Provisional; Region: PRK05218
339671002912	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
339671002913	ATP binding site [chemical binding]; other site
339671002914	Mg2+ binding site [ion binding]; other site
339671002915	G-X-G motif; other site
339671002916	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
339671002917	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
339671002918	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
339671002919	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
339671002920	dimer interface [polypeptide binding]; other site
339671002921	ADP-ribose binding site [chemical binding]; other site
339671002922	active site
339671002923	nudix motif; other site
339671002924	metal binding site [ion binding]; metal-binding site
339671002925	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
339671002926	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
339671002927	active site
339671002928	metal binding site [ion binding]; metal-binding site
339671002929	hexamer interface [polypeptide binding]; other site
339671002930	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
339671002931	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671002932	Walker A/P-loop; other site
339671002933	ATP binding site [chemical binding]; other site
339671002934	Q-loop/lid; other site
339671002935	ABC transporter signature motif; other site
339671002936	Walker B; other site
339671002937	D-loop; other site
339671002938	H-loop/switch region; other site
339671002939	heme exporter protein CcmB; Region: ccmB; TIGR01190
339671002940	heme exporter protein CcmC; Region: ccmC; TIGR01191
339671002941	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
339671002942	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
339671002943	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
339671002944	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
339671002945	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
339671002946	catalytic residues [active]
339671002947	central insert; other site
339671002948	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
339671002949	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
339671002950	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
339671002951	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
339671002952	TPR motif; other site
339671002953	binding surface
339671002954	glutamate racemase; Provisional; Region: PRK00865
339671002955	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
339671002956	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
339671002957	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
339671002958	putative active site [active]
339671002959	putative metal binding site [ion binding]; other site
339671002960	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
339671002961	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
339671002962	DXD motif; other site
339671002963	two-component sensor protein; Provisional; Region: cpxA; PRK09470
339671002964	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
339671002965	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
339671002966	active site
339671002967	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
339671002968	dimer interface [polypeptide binding]; other site
339671002969	phosphorylation site [posttranslational modification]
339671002970	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
339671002971	ATP binding site [chemical binding]; other site
339671002972	Mg2+ binding site [ion binding]; other site
339671002973	G-X-G motif; other site
339671002974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
339671002975	Response regulator receiver domain; Region: Response_reg; pfam00072
339671002976	active site
339671002977	phosphorylation site [posttranslational modification]
339671002978	intermolecular recognition site; other site
339671002979	dimerization interface [polypeptide binding]; other site
339671002980	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
339671002981	Hpt domain; Region: Hpt; pfam01627
339671002982	putative binding surface; other site
339671002983	active site
339671002984	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
339671002985	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
339671002986	active site
339671002987	dimerization interface [polypeptide binding]; other site
339671002988	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
339671002989	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
339671002990	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
339671002991	Rrf2 family protein; Region: rrf2_super; TIGR00738
339671002992	cysteine desulfurase; Provisional; Region: PRK14012
339671002993	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
339671002994	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
339671002995	catalytic residue [active]
339671002996	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
339671002997	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
339671002998	trimerization site [polypeptide binding]; other site
339671002999	active site
339671003000	iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011
339671003001	co-chaperone HscB; Provisional; Region: hscB; PRK01773
339671003002	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
339671003003	HSP70 interaction site [polypeptide binding]; other site
339671003004	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
339671003005	chaperone protein HscA; Provisional; Region: hscA; PRK05183
339671003006	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
339671003007	nucleotide binding site [chemical binding]; other site
339671003008	putative NEF/HSP70 interaction site [polypeptide binding]; other site
339671003009	SBD interface [polypeptide binding]; other site
339671003010	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
339671003011	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
339671003012	catalytic loop [active]
339671003013	iron binding site [ion binding]; other site
339671003014	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
339671003015	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
339671003016	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
339671003017	Sugar specificity; other site
339671003018	Pyrimidine base specificity; other site
339671003019	ATP-binding site [chemical binding]; other site
339671003020	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
339671003021	trimer interface [polypeptide binding]; other site
339671003022	active site
339671003023	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
339671003024	GTP-binding protein Der; Reviewed; Region: PRK00093
339671003025	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
339671003026	G1 box; other site
339671003027	GTP/Mg2+ binding site [chemical binding]; other site
339671003028	Switch I region; other site
339671003029	G2 box; other site
339671003030	Switch II region; other site
339671003031	G3 box; other site
339671003032	G4 box; other site
339671003033	G5 box; other site
339671003034	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
339671003035	G1 box; other site
339671003036	GTP/Mg2+ binding site [chemical binding]; other site
339671003037	Switch I region; other site
339671003038	G2 box; other site
339671003039	G3 box; other site
339671003040	Switch II region; other site
339671003041	G4 box; other site
339671003042	G5 box; other site
339671003043	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
339671003044	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
339671003045	active site
339671003046	catalytic site [active]
339671003047	substrate binding site [chemical binding]; other site
339671003048	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
339671003049	RNA/DNA hybrid binding site [nucleotide binding]; other site
339671003050	active site
339671003051	LexA repressor; Validated; Region: PRK00215
339671003052	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
339671003053	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
339671003054	Catalytic site [active]
339671003055	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
339671003056	SmpB-tmRNA interface; other site
339671003057	two-component response regulator; Provisional; Region: PRK11173
339671003058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
339671003059	active site
339671003060	phosphorylation site [posttranslational modification]
339671003061	intermolecular recognition site; other site
339671003062	dimerization interface [polypeptide binding]; other site
339671003063	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
339671003064	DNA binding site [nucleotide binding]
339671003065	YciI-like protein; Reviewed; Region: PRK11370
339671003066	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
339671003067	intracellular septation protein A; Reviewed; Region: PRK00259
339671003068	recombination and repair protein; Provisional; Region: PRK10869
339671003069	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
339671003070	Walker A/P-loop; other site
339671003071	ATP binding site [chemical binding]; other site
339671003072	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
339671003073	ABC transporter signature motif; other site
339671003074	Walker B; other site
339671003075	D-loop; other site
339671003076	H-loop/switch region; other site
339671003077	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
339671003078	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
339671003079	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
339671003080	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
339671003081	dimer interface [polypeptide binding]; other site
339671003082	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
339671003083	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
339671003084	Uncharacterized conserved protein [Function unknown]; Region: COG4121
339671003085	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
339671003086	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
339671003087	dimer interface [polypeptide binding]; other site
339671003088	active site
339671003089	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
339671003090	fructuronate transporter; Provisional; Region: PRK10034; cl15264
339671003091	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
339671003092	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
339671003093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
339671003094	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
339671003095	putative RNA binding site [nucleotide binding]; other site
339671003096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671003097	S-adenosylmethionine binding site [chemical binding]; other site
339671003098	N-acetylglutamate synthase; Validated; Region: PRK05279
339671003099	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
339671003100	putative feedback inhibition sensing region; other site
339671003101	putative nucleotide binding site [chemical binding]; other site
339671003102	putative substrate binding site [chemical binding]; other site
339671003103	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
339671003104	Coenzyme A binding pocket [chemical binding]; other site
339671003105	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
339671003106	HTH domain; Region: HTH_11; cl17392
339671003107	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
339671003108	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
339671003109	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
339671003110	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
339671003111	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
339671003112	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
339671003113	active site
339671003114	Uncharacterized conserved protein [Function unknown]; Region: COG3791
339671003115	GMP synthase; Reviewed; Region: guaA; PRK00074
339671003116	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
339671003117	AMP/PPi binding site [chemical binding]; other site
339671003118	candidate oxyanion hole; other site
339671003119	catalytic triad [active]
339671003120	potential glutamine specificity residues [chemical binding]; other site
339671003121	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
339671003122	ATP Binding subdomain [chemical binding]; other site
339671003123	Ligand Binding sites [chemical binding]; other site
339671003124	Dimerization subdomain; other site
339671003125	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
339671003126	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
339671003127	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
339671003128	molybdopterin cofactor binding site [chemical binding]; other site
339671003129	substrate binding site [chemical binding]; other site
339671003130	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
339671003131	molybdopterin cofactor binding site; other site
339671003132	chaperone protein TorD; Validated; Region: torD; PRK04976
339671003133	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
339671003134	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
339671003135	intersubunit interface [polypeptide binding]; other site
339671003136	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523
339671003137	metal binding site [ion binding]; metal-binding site
339671003138	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
339671003139	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
339671003140	intersubunit interface [polypeptide binding]; other site
339671003141	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
339671003142	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
339671003143	ABC-ATPase subunit  interface; other site
339671003144	dimer interface [polypeptide binding]; other site
339671003145	putative PBP binding regions; other site
339671003146	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
339671003147	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
339671003148	Walker A/P-loop; other site
339671003149	ATP binding site [chemical binding]; other site
339671003150	Q-loop/lid; other site
339671003151	ABC transporter signature motif; other site
339671003152	Walker B; other site
339671003153	D-loop; other site
339671003154	H-loop/switch region; other site
339671003155	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
339671003156	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
339671003157	ATP-grasp domain; Region: ATP-grasp_4; cl17255
339671003158	Methyltransferase domain; Region: Methyltransf_23; pfam13489
339671003159	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671003160	S-adenosylmethionine binding site [chemical binding]; other site
339671003161	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
339671003162	Na binding site [ion binding]; other site
339671003163	ribonuclease G; Provisional; Region: PRK11712
339671003164	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
339671003165	homodimer interface [polypeptide binding]; other site
339671003166	oligonucleotide binding site [chemical binding]; other site
339671003167	protease TldD; Provisional; Region: tldD; PRK10735
339671003168	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
339671003169	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
339671003170	inhibitor-cofactor binding pocket; inhibition site
339671003171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671003172	catalytic residue [active]
339671003173	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
339671003174	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
339671003175	active site turn [active]
339671003176	phosphorylation site [posttranslational modification]
339671003177	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
339671003178	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
339671003179	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
339671003180	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
339671003181	substrate binding pocket [chemical binding]; other site
339671003182	chain length determination region; other site
339671003183	substrate-Mg2+ binding site; other site
339671003184	catalytic residues [active]
339671003185	aspartate-rich region 1; other site
339671003186	active site lid residues [active]
339671003187	aspartate-rich region 2; other site
339671003188	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
339671003189	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
339671003190	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
339671003191	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
339671003192	EamA-like transporter family; Region: EamA; pfam00892
339671003193	EamA-like transporter family; Region: EamA; pfam00892
339671003194	GTPase CgtA; Reviewed; Region: obgE; PRK12298
339671003195	GTP1/OBG; Region: GTP1_OBG; pfam01018
339671003196	Obg GTPase; Region: Obg; cd01898
339671003197	G1 box; other site
339671003198	GTP/Mg2+ binding site [chemical binding]; other site
339671003199	Switch I region; other site
339671003200	G2 box; other site
339671003201	G3 box; other site
339671003202	Switch II region; other site
339671003203	G4 box; other site
339671003204	G5 box; other site
339671003205	hypothetical protein; Provisional; Region: PRK05423
339671003206	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
339671003207	homodimer interface [polypeptide binding]; other site
339671003208	substrate-cofactor binding pocket; other site
339671003209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671003210	catalytic residue [active]
339671003211	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
339671003212	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
339671003213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671003214	homodimer interface [polypeptide binding]; other site
339671003215	catalytic residue [active]
339671003216	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
339671003217	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
339671003218	hinge; other site
339671003219	active site
339671003220	aspartate kinase III; Validated; Region: PRK09084
339671003221	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
339671003222	nucleotide binding site [chemical binding]; other site
339671003223	substrate binding site [chemical binding]; other site
339671003224	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
339671003225	lysine allosteric regulatory site; other site
339671003226	dimer interface [polypeptide binding]; other site
339671003227	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
339671003228	dimer interface [polypeptide binding]; other site
339671003229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
339671003230	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
339671003231	OstA-like protein; Region: OstA; cl00844
339671003232	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
339671003233	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
339671003234	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
339671003235	Walker A/P-loop; other site
339671003236	ATP binding site [chemical binding]; other site
339671003237	Q-loop/lid; other site
339671003238	ABC transporter signature motif; other site
339671003239	Walker B; other site
339671003240	D-loop; other site
339671003241	H-loop/switch region; other site
339671003242	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
339671003243	active site
339671003244	phosphorylation site [posttranslational modification]
339671003245	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
339671003246	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
339671003247	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
339671003248	putative catalytic cysteine [active]
339671003249	DNA polymerase III subunit psi; Validated; Region: PRK06856
339671003250	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
339671003251	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
339671003252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671003253	S-adenosylmethionine binding site [chemical binding]; other site
339671003254	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
339671003255	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
339671003256	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
339671003257	Protein of unknown function (DUF986); Region: DUF986; pfam06173
339671003258	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
339671003259	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
339671003260	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
339671003261	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
339671003262	active pocket/dimerization site; other site
339671003263	active site
339671003264	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
339671003265	active site
339671003266	phosphorylation site [posttranslational modification]
339671003267	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
339671003268	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
339671003269	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
339671003270	dimer interface [polypeptide binding]; other site
339671003271	TPP-binding site [chemical binding]; other site
339671003272	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
339671003273	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
339671003274	E3 interaction surface; other site
339671003275	lipoyl attachment site [posttranslational modification]; other site
339671003276	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
339671003277	E3 interaction surface; other site
339671003278	lipoyl attachment site [posttranslational modification]; other site
339671003279	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
339671003280	E3 interaction surface; other site
339671003281	lipoyl attachment site [posttranslational modification]; other site
339671003282	e3 binding domain; Region: E3_binding; pfam02817
339671003283	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
339671003284	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
339671003285	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
339671003286	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
339671003287	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
339671003288	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
339671003289	NlpC/P60 family; Region: NLPC_P60; pfam00877
339671003290	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
339671003291	Catalytic site [active]
339671003292	serine/threonine transporter SstT; Provisional; Region: PRK13628
339671003293	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
339671003294	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
339671003295	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671003296	Walker A/P-loop; other site
339671003297	ATP binding site [chemical binding]; other site
339671003298	Q-loop/lid; other site
339671003299	ABC transporter signature motif; other site
339671003300	Walker B; other site
339671003301	D-loop; other site
339671003302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671003303	Walker A/P-loop; other site
339671003304	ATP binding site [chemical binding]; other site
339671003305	Q-loop/lid; other site
339671003306	ABC transporter signature motif; other site
339671003307	Walker B; other site
339671003308	D-loop; other site
339671003309	H-loop/switch region; other site
339671003310	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
339671003311	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
339671003312	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
339671003313	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
339671003314	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
339671003315	multifunctional aminopeptidase A; Provisional; Region: PRK00913
339671003316	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
339671003317	interface (dimer of trimers) [polypeptide binding]; other site
339671003318	Substrate-binding/catalytic site; other site
339671003319	Zn-binding sites [ion binding]; other site
339671003320	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
339671003321	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
339671003322	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
339671003323	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
339671003324	fumarate hydratase; Reviewed; Region: fumC; PRK00485
339671003325	Class II fumarases; Region: Fumarase_classII; cd01362
339671003326	active site
339671003327	tetramer interface [polypeptide binding]; other site
339671003328	hypothetical protein; Provisional; Region: PRK05415
339671003329	Domain of unknown function (DUF697); Region: DUF697; cl12064
339671003330	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
339671003331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671003332	Walker A motif; other site
339671003333	ATP binding site [chemical binding]; other site
339671003334	Walker B motif; other site
339671003335	arginine finger; other site
339671003336	ferric uptake regulator; Provisional; Region: fur; PRK09462
339671003337	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
339671003338	metal binding site 2 [ion binding]; metal-binding site
339671003339	putative DNA binding helix; other site
339671003340	metal binding site 1 [ion binding]; metal-binding site
339671003341	dimer interface [polypeptide binding]; other site
339671003342	structural Zn2+ binding site [ion binding]; other site
339671003343	flavodoxin FldA; Validated; Region: PRK09267
339671003344	LexA regulated protein; Provisional; Region: PRK11675
339671003345	acyl-CoA esterase; Provisional; Region: PRK10673
339671003346	PGAP1-like protein; Region: PGAP1; pfam07819
339671003347	replication initiation regulator SeqA; Provisional; Region: PRK11187
339671003348	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
339671003349	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
339671003350	acyl-activating enzyme (AAE) consensus motif; other site
339671003351	putative AMP binding site [chemical binding]; other site
339671003352	putative active site [active]
339671003353	putative CoA binding site [chemical binding]; other site
339671003354	hypothetical protein; Provisional; Region: PRK11281
339671003355	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
339671003356	Mechanosensitive ion channel; Region: MS_channel; pfam00924
339671003357	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
339671003358	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
339671003359	Tetramer interface [polypeptide binding]; other site
339671003360	active site
339671003361	FMN-binding site [chemical binding]; other site
339671003362	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
339671003363	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
339671003364	hypothetical protein; Provisional; Region: PRK10621
339671003365	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
339671003366	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
339671003367	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
339671003368	putative acyl-acceptor binding pocket; other site
339671003369	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
339671003370	active site
339671003371	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
339671003372	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671003373	Walker A motif; other site
339671003374	ATP binding site [chemical binding]; other site
339671003375	Walker B motif; other site
339671003376	DNA polymerase III subunit delta'; Validated; Region: PRK08485
339671003377	arginine finger; other site
339671003378	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
339671003379	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
339671003380	transcriptional antiterminator BglG; Provisional; Region: PRK09772
339671003381	CAT RNA binding domain; Region: CAT_RBD; smart01061
339671003382	PRD domain; Region: PRD; pfam00874
339671003383	PRD domain; Region: PRD; pfam00874
339671003384	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
339671003385	beta-galactosidase; Region: BGL; TIGR03356
339671003386	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
339671003387	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671003388	active site
339671003389	motif I; other site
339671003390	motif II; other site
339671003391	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
339671003392	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
339671003393	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
339671003394	active site turn [active]
339671003395	phosphorylation site [posttranslational modification]
339671003396	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
339671003397	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
339671003398	HPr interaction site; other site
339671003399	glycerol kinase (GK) interaction site [polypeptide binding]; other site
339671003400	active site
339671003401	phosphorylation site [posttranslational modification]
339671003402	YwiC-like protein; Region: YwiC; pfam14256
339671003403	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
339671003404	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
339671003405	CAP-like domain; other site
339671003406	active site
339671003407	primary dimer interface [polypeptide binding]; other site
339671003408	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
339671003409	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
339671003410	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
339671003411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
339671003412	ATP binding site [chemical binding]; other site
339671003413	Mg2+ binding site [ion binding]; other site
339671003414	G-X-G motif; other site
339671003415	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
339671003416	anchoring element; other site
339671003417	dimer interface [polypeptide binding]; other site
339671003418	ATP binding site [chemical binding]; other site
339671003419	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
339671003420	active site
339671003421	putative metal-binding site [ion binding]; other site
339671003422	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
339671003423	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
339671003424	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
339671003425	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
339671003426	ABC transporter; Region: ABC_tran_2; pfam12848
339671003427	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
339671003428	putative protease; Provisional; Region: PRK15452
339671003429	Peptidase family U32; Region: Peptidase_U32; pfam01136
339671003430	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
339671003431	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
339671003432	G1 box; other site
339671003433	putative GEF interaction site [polypeptide binding]; other site
339671003434	GTP/Mg2+ binding site [chemical binding]; other site
339671003435	Switch I region; other site
339671003436	G2 box; other site
339671003437	G3 box; other site
339671003438	Switch II region; other site
339671003439	G4 box; other site
339671003440	G5 box; other site
339671003441	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
339671003442	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
339671003443	ATP binding site [chemical binding]; other site
339671003444	active site
339671003445	substrate binding site [chemical binding]; other site
339671003446	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
339671003447	NADH(P)-binding; Region: NAD_binding_10; pfam13460
339671003448	NAD(P) binding site [chemical binding]; other site
339671003449	active site
339671003450	argininosuccinate synthase; Validated; Region: PRK05370
339671003451	argininosuccinate synthase; Provisional; Region: PRK13820
339671003452	GTPase HflX; Provisional; Region: PRK11058
339671003453	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
339671003454	HflX GTPase family; Region: HflX; cd01878
339671003455	G1 box; other site
339671003456	GTP/Mg2+ binding site [chemical binding]; other site
339671003457	Switch I region; other site
339671003458	G2 box; other site
339671003459	G3 box; other site
339671003460	Switch II region; other site
339671003461	G4 box; other site
339671003462	G5 box; other site
339671003463	bacterial Hfq-like; Region: Hfq; cd01716
339671003464	hexamer interface [polypeptide binding]; other site
339671003465	Sm1 motif; other site
339671003466	RNA binding site [nucleotide binding]; other site
339671003467	Sm2 motif; other site
339671003468	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
339671003469	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
339671003470	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
339671003471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
339671003472	ATP binding site [chemical binding]; other site
339671003473	Mg2+ binding site [ion binding]; other site
339671003474	G-X-G motif; other site
339671003475	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
339671003476	ATP binding site [chemical binding]; other site
339671003477	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
339671003478	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
339671003479	active site
339671003480	metal binding site [ion binding]; metal-binding site
339671003481	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
339671003482	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
339671003483	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
339671003484	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
339671003485	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
339671003486	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
339671003487	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
339671003488	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
339671003489	catalytic site [active]
339671003490	putative active site [active]
339671003491	putative substrate binding site [chemical binding]; other site
339671003492	dimer interface [polypeptide binding]; other site
339671003493	GTPase RsgA; Reviewed; Region: PRK12288
339671003494	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
339671003495	RNA binding site [nucleotide binding]; other site
339671003496	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
339671003497	GTPase/Zn-binding domain interface [polypeptide binding]; other site
339671003498	GTP/Mg2+ binding site [chemical binding]; other site
339671003499	G4 box; other site
339671003500	G5 box; other site
339671003501	G1 box; other site
339671003502	Switch I region; other site
339671003503	G2 box; other site
339671003504	G3 box; other site
339671003505	Switch II region; other site
339671003506	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
339671003507	dimerization domain swap beta strand [polypeptide binding]; other site
339671003508	regulatory protein interface [polypeptide binding]; other site
339671003509	active site
339671003510	regulatory phosphorylation site [posttranslational modification]; other site
339671003511	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
339671003512	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
339671003513	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
339671003514	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
339671003515	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
339671003516	HPr interaction site; other site
339671003517	glycerol kinase (GK) interaction site [polypeptide binding]; other site
339671003518	active site
339671003519	phosphorylation site [posttranslational modification]
339671003520	hypothetical protein; Validated; Region: PRK00153
339671003521	recombination protein RecR; Reviewed; Region: recR; PRK00076
339671003522	RecR protein; Region: RecR; pfam02132
339671003523	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
339671003524	putative active site [active]
339671003525	putative metal-binding site [ion binding]; other site
339671003526	tetramer interface [polypeptide binding]; other site
339671003527	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
339671003528	TIGR01666 family membrane protein; Region: YCCS
339671003529	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
339671003530	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
339671003531	hypothetical protein; Provisional; Region: PRK11770
339671003532	Domain of unknown function (DUF307); Region: DUF307; pfam03733
339671003533	Domain of unknown function (DUF307); Region: DUF307; pfam03733
339671003534	hypothetical protein; Provisional; Region: PRK01904
339671003535	acylphosphatase; Provisional; Region: PRK14448
339671003536	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
339671003537	DsrC like protein; Region: DsrC; pfam04358
339671003538	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
339671003539	YccA-like proteins; Region: YccA_like; cd10433
339671003540	haemagglutination activity domain; Region: Haemagg_act; pfam05860
339671003541	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
339671003542	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
339671003543	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
339671003544	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
339671003545	Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829
339671003546	Protein of unknown function (DUF1436); Region: DUF1436; pfam07262
339671003547	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
339671003548	FeoA domain; Region: FeoA; pfam04023
339671003549	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
339671003550	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
339671003551	G1 box; other site
339671003552	GTP/Mg2+ binding site [chemical binding]; other site
339671003553	Switch I region; other site
339671003554	G2 box; other site
339671003555	G3 box; other site
339671003556	Switch II region; other site
339671003557	G4 box; other site
339671003558	G5 box; other site
339671003559	Nucleoside recognition; Region: Gate; pfam07670
339671003560	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
339671003561	Nucleoside recognition; Region: Gate; pfam07670
339671003562	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
339671003563	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
339671003564	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
339671003565	N-terminal plug; other site
339671003566	ligand-binding site [chemical binding]; other site
339671003567	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
339671003568	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
339671003569	ABC-ATPase subunit  interface; other site
339671003570	dimer interface [polypeptide binding]; other site
339671003571	putative PBP binding regions; other site
339671003572	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
339671003573	ABC-ATPase subunit  interface; other site
339671003574	dimer interface [polypeptide binding]; other site
339671003575	putative PBP binding regions; other site
339671003576	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
339671003577	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
339671003578	siderophore binding site; other site
339671003579	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
339671003580	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
339671003581	Walker A/P-loop; other site
339671003582	ATP binding site [chemical binding]; other site
339671003583	Q-loop/lid; other site
339671003584	ABC transporter signature motif; other site
339671003585	Walker B; other site
339671003586	D-loop; other site
339671003587	H-loop/switch region; other site
339671003588	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
339671003589	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
339671003590	ligand binding site [chemical binding]; other site
339671003591	homodimer interface [polypeptide binding]; other site
339671003592	NAD(P) binding site [chemical binding]; other site
339671003593	trimer interface B [polypeptide binding]; other site
339671003594	trimer interface A [polypeptide binding]; other site
339671003595	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
339671003596	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
339671003597	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
339671003598	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
339671003599	Pathogenicity locus; Region: Cdd1; pfam11731
339671003600	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
339671003601	generic binding surface II; other site
339671003602	ssDNA binding site; other site
339671003603	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
339671003604	ATP binding site [chemical binding]; other site
339671003605	putative Mg++ binding site [ion binding]; other site
339671003606	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
339671003607	nucleotide binding region [chemical binding]; other site
339671003608	ATP-binding site [chemical binding]; other site
339671003609	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
339671003610	Zn2+ binding site [ion binding]; other site
339671003611	Mg2+ binding site [ion binding]; other site
339671003612	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
339671003613	synthetase active site [active]
339671003614	NTP binding site [chemical binding]; other site
339671003615	metal binding site [ion binding]; metal-binding site
339671003616	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
339671003617	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
339671003618	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
339671003619	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
339671003620	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
339671003621	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
339671003622	catalytic site [active]
339671003623	G-X2-G-X-G-K; other site
339671003624	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
339671003625	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
339671003626	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
339671003627	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
339671003628	Transglycosylase; Region: Transgly; pfam00912
339671003629	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
339671003630	Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062
339671003631	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
339671003632	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
339671003633	active site
339671003634	PII uridylyl-transferase; Provisional; Region: glnD; PRK01759
339671003635	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
339671003636	metal binding triad; other site
339671003637	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
339671003638	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
339671003639	Zn2+ binding site [ion binding]; other site
339671003640	Mg2+ binding site [ion binding]; other site
339671003641	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
339671003642	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
339671003643	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
339671003644	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
339671003645	DNA binding residues [nucleotide binding]
339671003646	dimer interface [polypeptide binding]; other site
339671003647	copper binding site [ion binding]; other site
339671003648	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
339671003649	metal-binding site [ion binding]
339671003650	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
339671003651	copper exporting ATPase; Provisional; Region: copA; PRK10671
339671003652	metal-binding site [ion binding]
339671003653	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
339671003654	metal-binding site [ion binding]
339671003655	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
339671003656	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671003657	motif II; other site
339671003658	ABC transporter ATPase component; Reviewed; Region: PRK11147
339671003659	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
339671003660	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
339671003661	ABC transporter; Region: ABC_tran_2; pfam12848
339671003662	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
339671003663	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
339671003664	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
339671003665	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
339671003666	putative active site [active]
339671003667	putative substrate binding site [chemical binding]; other site
339671003668	putative cosubstrate binding site; other site
339671003669	catalytic site [active]
339671003670	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
339671003671	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
339671003672	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
339671003673	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
339671003674	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06882
339671003675	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
339671003676	PYR/PP interface [polypeptide binding]; other site
339671003677	dimer interface [polypeptide binding]; other site
339671003678	TPP binding site [chemical binding]; other site
339671003679	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
339671003680	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
339671003681	TPP-binding site [chemical binding]; other site
339671003682	dimer interface [polypeptide binding]; other site
339671003683	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
339671003684	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
339671003685	putative valine binding site [chemical binding]; other site
339671003686	dimer interface [polypeptide binding]; other site
339671003687	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
339671003688	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
339671003689	Sulfatase; Region: Sulfatase; pfam00884
339671003690	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
339671003691	GSH binding site [chemical binding]; other site
339671003692	catalytic residues [active]
339671003693	hypothetical protein; Provisional; Region: PRK04940
339671003694	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
339671003695	FAD binding domain; Region: FAD_binding_4; pfam01565
339671003696	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
339671003697	outer membrane protein A; Reviewed; Region: PRK10808
339671003698	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
339671003699	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
339671003700	ligand binding site [chemical binding]; other site
339671003701	LemA family; Region: LemA; pfam04011
339671003702	Repair protein; Region: Repair_PSII; cl01535
339671003703	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
339671003704	Repair protein; Region: Repair_PSII; pfam04536
339671003705	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
339671003706	putative GSH binding site [chemical binding]; other site
339671003707	catalytic residues [active]
339671003708	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
339671003709	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
339671003710	Protein export membrane protein; Region: SecD_SecF; pfam02355
339671003711	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
339671003712	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
339671003713	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
339671003714	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
339671003715	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
339671003716	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
339671003717	CPxP  motif; other site
339671003718	Hemerythrin-like domain; Region: Hr-like; cd12108
339671003719	Fe binding site [ion binding]; other site
339671003720	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
339671003721	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
339671003722	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
339671003723	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
339671003724	DNA polymerase III subunit chi; Validated; Region: PRK05728
339671003725	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
339671003726	Coenzyme A binding pocket [chemical binding]; other site
339671003727	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
339671003728	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
339671003729	HIGH motif; other site
339671003730	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
339671003731	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
339671003732	active site
339671003733	KMSKS motif; other site
339671003734	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
339671003735	tRNA binding surface [nucleotide binding]; other site
339671003736	anticodon binding site; other site
339671003737	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
339671003738	allantoate amidohydrolase; Reviewed; Region: PRK09290
339671003739	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
339671003740	active site
339671003741	metal binding site [ion binding]; metal-binding site
339671003742	dimer interface [polypeptide binding]; other site
339671003743	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
339671003744	active site pocket [active]
339671003745	oxyanion hole [active]
339671003746	catalytic triad [active]
339671003747	active site nucleophile [active]
339671003748	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
339671003749	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
339671003750	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
339671003751	putative metal binding site [ion binding]; other site
339671003752	dimer interface [polypeptide binding]; other site
339671003753	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
339671003754	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
339671003755	NAD(P) binding site [chemical binding]; other site
339671003756	catalytic residues [active]
339671003757	exoribonuclease II; Provisional; Region: PRK05054
339671003758	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
339671003759	RNB domain; Region: RNB; pfam00773
339671003760	S1 RNA binding domain; Region: S1; pfam00575
339671003761	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
339671003762	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
339671003763	NAD binding site [chemical binding]; other site
339671003764	homotetramer interface [polypeptide binding]; other site
339671003765	homodimer interface [polypeptide binding]; other site
339671003766	substrate binding site [chemical binding]; other site
339671003767	active site
339671003768	Uncharacterized conserved protein [Function unknown]; Region: COG0327
339671003769	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
339671003770	FtsH protease regulator HflC; Provisional; Region: PRK11029
339671003771	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
339671003772	FtsH protease regulator HflK; Provisional; Region: PRK10930
339671003773	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
339671003774	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
339671003775	AMP binding site [chemical binding]; other site
339671003776	metal binding site [ion binding]; metal-binding site
339671003777	active site
339671003778	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
339671003779	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
339671003780	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
339671003781	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
339671003782	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
339671003783	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
339671003784	active site
339671003785	NTP binding site [chemical binding]; other site
339671003786	metal binding triad [ion binding]; metal-binding site
339671003787	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
339671003788	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
339671003789	Bacterial SH3 domain homologues; Region: SH3b; smart00287
339671003790	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
339671003791	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
339671003792	TIGR00153 family protein; Region: TIGR00153
339671003793	Uncharacterized conserved protein [Function unknown]; Region: COG3025
339671003794	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
339671003795	putative active site [active]
339671003796	putative metal binding residues [ion binding]; other site
339671003797	signature motif; other site
339671003798	putative triphosphate binding site [ion binding]; other site
339671003799	DNA repair protein RadA; Region: sms; TIGR00416
339671003800	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
339671003801	Walker A motif/ATP binding site; other site
339671003802	ATP binding site [chemical binding]; other site
339671003803	Walker B motif; other site
339671003804	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
339671003805	mce related protein; Region: MCE; pfam02470
339671003806	mce related protein; Region: MCE; pfam02470
339671003807	mce related protein; Region: MCE; pfam02470
339671003808	mce related protein; Region: MCE; pfam02470
339671003809	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
339671003810	Paraquat-inducible protein A; Region: PqiA; pfam04403
339671003811	Paraquat-inducible protein A; Region: PqiA; pfam04403
339671003812	putative RNA binding sites [nucleotide binding]; other site
339671003813	ProP expression regulator; Provisional; Region: PRK04950
339671003814	ProQ/FINO family; Region: ProQ; smart00945
339671003815	carboxy-terminal protease; Provisional; Region: PRK11186
339671003816	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
339671003817	protein binding site [polypeptide binding]; other site
339671003818	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
339671003819	Catalytic dyad [active]
339671003820	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
339671003821	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
339671003822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
339671003823	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
339671003824	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
339671003825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
339671003826	Peptidase M15; Region: Peptidase_M15_3; cl01194
339671003827	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
339671003828	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
339671003829	excinuclease ABC subunit B; Provisional; Region: PRK05298
339671003830	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
339671003831	ATP binding site [chemical binding]; other site
339671003832	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
339671003833	nucleotide binding region [chemical binding]; other site
339671003834	ATP-binding site [chemical binding]; other site
339671003835	Ultra-violet resistance protein B; Region: UvrB; pfam12344
339671003836	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
339671003837	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
339671003838	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
339671003839	chaperone protein DnaJ; Provisional; Region: PRK10767
339671003840	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
339671003841	HSP70 interaction site [polypeptide binding]; other site
339671003842	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
339671003843	substrate binding site [polypeptide binding]; other site
339671003844	dimer interface [polypeptide binding]; other site
339671003845	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
339671003846	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
339671003847	nucleotide binding site [chemical binding]; other site
339671003848	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
339671003849	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
339671003850	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
339671003851	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
339671003852	active site
339671003853	HIGH motif; other site
339671003854	KMSK motif region; other site
339671003855	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
339671003856	tRNA binding surface [nucleotide binding]; other site
339671003857	anticodon binding site; other site
339671003858	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
339671003859	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
339671003860	active site
339671003861	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
339671003862	catalytic triad [active]
339671003863	dimer interface [polypeptide binding]; other site
339671003864	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
339671003865	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
339671003866	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671003867	Walker A/P-loop; other site
339671003868	ATP binding site [chemical binding]; other site
339671003869	Q-loop/lid; other site
339671003870	ABC transporter signature motif; other site
339671003871	Walker B; other site
339671003872	D-loop; other site
339671003873	H-loop/switch region; other site
339671003874	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
339671003875	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
339671003876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671003877	Walker A/P-loop; other site
339671003878	ATP binding site [chemical binding]; other site
339671003879	Q-loop/lid; other site
339671003880	ABC transporter signature motif; other site
339671003881	Walker B; other site
339671003882	D-loop; other site
339671003883	H-loop/switch region; other site
339671003884	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
339671003885	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
339671003886	dimerization interface [polypeptide binding]; other site
339671003887	putative DNA binding site [nucleotide binding]; other site
339671003888	putative Zn2+ binding site [ion binding]; other site
339671003889	AsnC family; Region: AsnC_trans_reg; pfam01037
339671003890	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
339671003891	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671003892	Walker A motif; other site
339671003893	ATP binding site [chemical binding]; other site
339671003894	Walker B motif; other site
339671003895	arginine finger; other site
339671003896	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
339671003897	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
339671003898	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
339671003899	recombination factor protein RarA; Reviewed; Region: PRK13342
339671003900	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671003901	Walker A motif; other site
339671003902	ATP binding site [chemical binding]; other site
339671003903	Walker B motif; other site
339671003904	arginine finger; other site
339671003905	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
339671003906	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
339671003907	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
339671003908	active site
339671003909	dimer interface [polypeptide binding]; other site
339671003910	seryl-tRNA synthetase; Provisional; Region: PRK05431
339671003911	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
339671003912	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
339671003913	dimer interface [polypeptide binding]; other site
339671003914	active site
339671003915	motif 1; other site
339671003916	motif 2; other site
339671003917	motif 3; other site
339671003918	Predicted permeases [General function prediction only]; Region: COG0679
339671003919	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
339671003920	active site
339671003921	phosphate binding residues; other site
339671003922	catalytic residues [active]
339671003923	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
339671003924	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
339671003925	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
339671003926	Glycoprotease family; Region: Peptidase_M22; pfam00814
339671003927	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
339671003928	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
339671003929	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
339671003930	acyl-activating enzyme (AAE) consensus motif; other site
339671003931	putative AMP binding site [chemical binding]; other site
339671003932	putative active site [active]
339671003933	putative CoA binding site [chemical binding]; other site
339671003934	ribonuclease D; Provisional; Region: PRK10829
339671003935	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
339671003936	catalytic site [active]
339671003937	putative active site [active]
339671003938	putative substrate binding site [chemical binding]; other site
339671003939	HRDC domain; Region: HRDC; pfam00570
339671003940	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
339671003941	putative metal binding site [ion binding]; other site
339671003942	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
339671003943	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
339671003944	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
339671003945	peptide binding site [polypeptide binding]; other site
339671003946	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
339671003947	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
339671003948	tRNA; other site
339671003949	putative tRNA binding site [nucleotide binding]; other site
339671003950	putative NADP binding site [chemical binding]; other site
339671003951	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
339671003952	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
339671003953	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
339671003954	ribosome maturation protein RimP; Reviewed; Region: PRK00092
339671003955	Sm and related proteins; Region: Sm_like; cl00259
339671003956	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
339671003957	putative oligomer interface [polypeptide binding]; other site
339671003958	putative RNA binding site [nucleotide binding]; other site
339671003959	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
339671003960	NusA N-terminal domain; Region: NusA_N; pfam08529
339671003961	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
339671003962	RNA binding site [nucleotide binding]; other site
339671003963	homodimer interface [polypeptide binding]; other site
339671003964	NusA-like KH domain; Region: KH_5; pfam13184
339671003965	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
339671003966	G-X-X-G motif; other site
339671003967	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
339671003968	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
339671003969	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
339671003970	translation initiation factor IF-2; Region: IF-2; TIGR00487
339671003971	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
339671003972	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
339671003973	G1 box; other site
339671003974	putative GEF interaction site [polypeptide binding]; other site
339671003975	GTP/Mg2+ binding site [chemical binding]; other site
339671003976	Switch I region; other site
339671003977	G2 box; other site
339671003978	G3 box; other site
339671003979	Switch II region; other site
339671003980	G4 box; other site
339671003981	G5 box; other site
339671003982	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
339671003983	Translation-initiation factor 2; Region: IF-2; pfam11987
339671003984	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
339671003985	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
339671003986	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
339671003987	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
339671003988	RNA binding site [nucleotide binding]; other site
339671003989	active site
339671003990	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
339671003991	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
339671003992	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
339671003993	Ligand Binding Site [chemical binding]; other site
339671003994	TilS substrate binding domain; Region: TilS; pfam09179
339671003995	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
339671003996	pyridoxamine kinase; Validated; Region: PRK05756
339671003997	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
339671003998	dimer interface [polypeptide binding]; other site
339671003999	pyridoxal binding site [chemical binding]; other site
339671004000	ATP binding site [chemical binding]; other site
339671004001	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
339671004002	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
339671004003	Domain of unknown function (DUF1919); Region: DUF1919; pfam08942
339671004004	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
339671004005	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
339671004006	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
339671004007	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671004008	dimer interface [polypeptide binding]; other site
339671004009	conserved gate region; other site
339671004010	putative PBP binding loops; other site
339671004011	ABC-ATPase subunit interface; other site
339671004012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671004013	dimer interface [polypeptide binding]; other site
339671004014	conserved gate region; other site
339671004015	putative PBP binding loops; other site
339671004016	ABC-ATPase subunit interface; other site
339671004017	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
339671004018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671004019	Walker A/P-loop; other site
339671004020	ATP binding site [chemical binding]; other site
339671004021	Q-loop/lid; other site
339671004022	ABC transporter signature motif; other site
339671004023	Walker B; other site
339671004024	D-loop; other site
339671004025	H-loop/switch region; other site
339671004026	biotin synthase; Provisional; Region: PRK15108
339671004027	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671004028	FeS/SAM binding site; other site
339671004029	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
339671004030	Protein of unknown function, DUF488; Region: DUF488; cl01246
339671004031	peroxidase; Provisional; Region: PRK15000
339671004032	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
339671004033	dimer interface [polypeptide binding]; other site
339671004034	decamer (pentamer of dimers) interface [polypeptide binding]; other site
339671004035	catalytic triad [active]
339671004036	peroxidatic and resolving cysteines [active]
339671004037	cystathionine beta-lyase; Provisional; Region: PRK08114
339671004038	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
339671004039	homodimer interface [polypeptide binding]; other site
339671004040	substrate-cofactor binding pocket; other site
339671004041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671004042	catalytic residue [active]
339671004043	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
339671004044	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
339671004045	dimer interface [polypeptide binding]; other site
339671004046	active site
339671004047	metal binding site [ion binding]; metal-binding site
339671004048	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
339671004049	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
339671004050	trimer interface [polypeptide binding]; other site
339671004051	eyelet of channel; other site
339671004052	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
339671004053	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
339671004054	sequence-specific DNA binding site [nucleotide binding]; other site
339671004055	salt bridge; other site
339671004056	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
339671004057	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
339671004058	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
339671004059	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
339671004060	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
339671004061	Walker A/P-loop; other site
339671004062	ATP binding site [chemical binding]; other site
339671004063	Q-loop/lid; other site
339671004064	ABC transporter signature motif; other site
339671004065	Walker B; other site
339671004066	D-loop; other site
339671004067	H-loop/switch region; other site
339671004068	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671004069	Walker A/P-loop; other site
339671004070	ATP binding site [chemical binding]; other site
339671004071	Q-loop/lid; other site
339671004072	ABC transporter signature motif; other site
339671004073	Walker B; other site
339671004074	D-loop; other site
339671004075	H-loop/switch region; other site
339671004076	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
339671004077	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
339671004078	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
339671004079	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
339671004080	HlyD family secretion protein; Region: HlyD_3; pfam13437
339671004081	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
339671004082	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
339671004083	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
339671004084	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
339671004085	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
339671004086	DsbD alpha interface [polypeptide binding]; other site
339671004087	catalytic residues [active]
339671004088	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
339671004089	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
339671004090	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
339671004091	purine monophosphate binding site [chemical binding]; other site
339671004092	dimer interface [polypeptide binding]; other site
339671004093	putative catalytic residues [active]
339671004094	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
339671004095	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
339671004096	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
339671004097	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
339671004098	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
339671004099	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
339671004100	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671004101	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671004102	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
339671004103	putative effector binding pocket; other site
339671004104	dimerization interface [polypeptide binding]; other site
339671004105	Membrane transport protein; Region: Mem_trans; cl09117
339671004106	Predicted membrane protein [Function unknown]; Region: COG2707
339671004107	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
339671004108	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
339671004109	ATP binding site [chemical binding]; other site
339671004110	putative Mg++ binding site [ion binding]; other site
339671004111	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
339671004112	nucleotide binding region [chemical binding]; other site
339671004113	ATP-binding site [chemical binding]; other site
339671004114	Helicase associated domain (HA2); Region: HA2; pfam04408
339671004115	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
339671004116	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
339671004117	Transglycosylase; Region: Transgly; pfam00912
339671004118	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
339671004119	Shikimate kinase; Region: SKI; pfam01202
339671004120	ATP-binding site [chemical binding]; other site
339671004121	Gluconate-6-phosphate binding site [chemical binding]; other site
339671004122	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
339671004123	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
339671004124	putative NAD(P) binding site [chemical binding]; other site
339671004125	catalytic Zn binding site [ion binding]; other site
339671004126	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
339671004127	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
339671004128	NADP binding site [chemical binding]; other site
339671004129	homodimer interface [polypeptide binding]; other site
339671004130	active site
339671004131	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
339671004132	fructuronate transporter; Provisional; Region: PRK10034; cl15264
339671004133	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
339671004134	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
339671004135	trimer interface [polypeptide binding]; other site
339671004136	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
339671004137	trimer interface [polypeptide binding]; other site
339671004138	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
339671004139	trimer interface [polypeptide binding]; other site
339671004140	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
339671004141	trimer interface [polypeptide binding]; other site
339671004142	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
339671004143	trimer interface [polypeptide binding]; other site
339671004144	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
339671004145	trimer interface [polypeptide binding]; other site
339671004146	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
339671004147	trimer interface [polypeptide binding]; other site
339671004148	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
339671004149	trimer interface [polypeptide binding]; other site
339671004150	YadA-like C-terminal region; Region: YadA; pfam03895
339671004151	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
339671004152	Sodium Bile acid symporter family; Region: SBF; pfam01758
339671004153	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
339671004154	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
339671004155	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
339671004156	protein binding site [polypeptide binding]; other site
339671004157	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
339671004158	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
339671004159	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
339671004160	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
339671004161	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
339671004162	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
339671004163	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
339671004164	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
339671004165	DctM-like transporters; Region: DctM; pfam06808
339671004166	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
339671004167	Transcriptional regulators [Transcription]; Region: PurR; COG1609
339671004168	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
339671004169	DNA binding site [nucleotide binding]
339671004170	domain linker motif; other site
339671004171	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
339671004172	putative dimerization interface [polypeptide binding]; other site
339671004173	putative ligand binding site [chemical binding]; other site
339671004174	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
339671004175	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
339671004176	substrate binding site [chemical binding]; other site
339671004177	ATP binding site [chemical binding]; other site
339671004178	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
339671004179	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
339671004180	dimerization interface [polypeptide binding]; other site
339671004181	ligand binding site [chemical binding]; other site
339671004182	NADP binding site [chemical binding]; other site
339671004183	catalytic site [active]
339671004184	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
339671004185	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
339671004186	pyruvate kinase; Provisional; Region: PRK05826
339671004187	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
339671004188	domain interfaces; other site
339671004189	active site
339671004190	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
339671004191	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
339671004192	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
339671004193	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
339671004194	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
339671004195	N-terminal plug; other site
339671004196	ligand-binding site [chemical binding]; other site
339671004197	multidrug efflux protein; Reviewed; Region: PRK01766
339671004198	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
339671004199	cation binding site [ion binding]; other site
339671004200	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
339671004201	Lumazine binding domain; Region: Lum_binding; pfam00677
339671004202	Lumazine binding domain; Region: Lum_binding; pfam00677
339671004203	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
339671004204	Predicted membrane protein [Function unknown]; Region: COG2246
339671004205	GtrA-like protein; Region: GtrA; pfam04138
339671004206	outer membrane lipoprotein; Provisional; Region: PRK11023
339671004207	BON domain; Region: BON; pfam04972
339671004208	BON domain; Region: BON; pfam04972
339671004209	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
339671004210	DsrE/DsrF-like family; Region: DrsE; cl00672
339671004211	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
339671004212	Family description; Region: UvrD_C_2; pfam13538
339671004213	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
339671004214	AAA domain; Region: AAA_30; pfam13604
339671004215	Family description; Region: UvrD_C_2; pfam13538
339671004216	Protein of unknown function (DUF808); Region: DUF808; pfam05661
339671004217	uncharacterized domain; Region: TIGR00702
339671004218	YcaO-like family; Region: YcaO; pfam02624
339671004219	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671004220	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
339671004221	DNA ligase; Provisional; Region: PRK09125
339671004222	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
339671004223	DNA binding site [nucleotide binding]
339671004224	active site
339671004225	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
339671004226	DNA binding site [nucleotide binding]
339671004227	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
339671004228	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
339671004229	Na binding site [ion binding]; other site
339671004230	putative substrate binding site [chemical binding]; other site
339671004231	cytosine deaminase; Provisional; Region: PRK09230
339671004232	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
339671004233	active site
339671004234	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
339671004235	substrate binding site [chemical binding]; other site
339671004236	THF binding site; other site
339671004237	zinc-binding site [ion binding]; other site
339671004238	OmpW family; Region: OmpW; cl17427
339671004239	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
339671004240	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
339671004241	DNA binding site [nucleotide binding]
339671004242	domain linker motif; other site
339671004243	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
339671004244	dimerization interface [polypeptide binding]; other site
339671004245	ligand binding site [chemical binding]; other site
339671004246	citrate lyase subunit gamma; Provisional; Region: PRK13253
339671004247	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
339671004248	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
339671004249	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
339671004250	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802
339671004251	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
339671004252	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
339671004253	active site clefts [active]
339671004254	zinc binding site [ion binding]; other site
339671004255	dimer interface [polypeptide binding]; other site
339671004256	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
339671004257	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
339671004258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
339671004259	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
339671004260	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
339671004261	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071
339671004262	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
339671004263	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
339671004264	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
339671004265	probable active site [active]
339671004266	Helix-turn-helix domain; Region: HTH_17; pfam12728
339671004267	Methyltransferase domain; Region: Methyltransf_25; pfam13649
339671004268	Protein of unknown function (DUF1071); Region: DUF1071; pfam06378
339671004269	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
339671004270	active site
339671004271	catalytic site [active]
339671004272	substrate binding site [chemical binding]; other site
339671004273	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
339671004274	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
339671004275	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
339671004276	sequence-specific DNA binding site [nucleotide binding]; other site
339671004277	salt bridge; other site
339671004278	Domain of unknown function (DUF955); Region: DUF955; pfam06114
339671004279	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
339671004280	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
339671004281	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
339671004282	non-specific DNA binding site [nucleotide binding]; other site
339671004283	salt bridge; other site
339671004284	sequence-specific DNA binding site [nucleotide binding]; other site
339671004285	Predicted transcriptional regulator [Transcription]; Region: COG2932
339671004286	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
339671004287	Catalytic site [active]
339671004288	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
339671004289	sequence-specific DNA binding site [nucleotide binding]; other site
339671004290	salt bridge; other site
339671004291	Helix-turn-helix domain; Region: HTH_39; pfam14090
339671004292	Replication protein P; Region: Phage_lambda_P; pfam06992
339671004293	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442
339671004294	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
339671004295	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
339671004296	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
339671004297	Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530
339671004298	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
339671004299	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
339671004300	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
339671004301	P22AR C-terminal domain; Region: P22_AR_C; pfam10548
339671004302	Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106
339671004303	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
339671004304	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
339671004305	active site
339671004306	Phage terminase, small subunit; Region: Terminase_4; pfam05119
339671004307	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
339671004308	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
339671004309	Phage-related protein [Function unknown]; Region: COG4695
339671004310	Phage portal protein; Region: Phage_portal; pfam04860
339671004311	Phage head maturation protease [General function prediction only]; Region: COG3740
339671004312	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
339671004313	Phage capsid family; Region: Phage_capsid; pfam05065
339671004314	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
339671004315	oligomerization interface [polypeptide binding]; other site
339671004316	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
339671004317	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
339671004318	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
339671004319	Protein of unknown function (DUF4035); Region: DUF4035; pfam13227
339671004320	tape measure domain; Region: tape_meas_nterm; TIGR02675
339671004321	Phage-related minor tail protein [Function unknown]; Region: COG5281
339671004322	Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120
339671004323	Phage minor tail protein; Region: Phage_min_tail; cl01940
339671004324	Phage-related protein [Function unknown]; Region: gp18; COG4672
339671004325	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
339671004326	MPN+ (JAMM) motif; other site
339671004327	Zinc-binding site [ion binding]; other site
339671004328	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
339671004329	NlpC/P60 family; Region: NLPC_P60; pfam00877
339671004330	Phage-related protein, tail component [Function unknown]; Region: COG4723
339671004331	Phage-related protein, tail component [Function unknown]; Region: COG4733
339671004332	Putative phage tail protein; Region: Phage-tail_3; pfam13550
339671004333	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
339671004334	Interdomain contacts; other site
339671004335	Cytokine receptor motif; other site
339671004336	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
339671004337	integrase; Provisional; Region: PRK09692
339671004338	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
339671004339	active site
339671004340	Int/Topo IB signature motif; other site
339671004341	dsDNA-mimic protein; Reviewed; Region: PRK05094
339671004342	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
339671004343	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671004344	active site
339671004345	motif I; other site
339671004346	motif II; other site
339671004347	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671004348	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
339671004349	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
339671004350	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
339671004351	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
339671004352	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
339671004353	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
339671004354	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
339671004355	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
339671004356	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
339671004357	molybdopterin cofactor binding site; other site
339671004358	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
339671004359	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
339671004360	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
339671004361	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
339671004362	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
339671004363	Part of AAA domain; Region: AAA_19; pfam13245
339671004364	Family description; Region: UvrD_C_2; pfam13538
339671004365	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
339671004366	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
339671004367	active site
339671004368	ribulose/triose binding site [chemical binding]; other site
339671004369	phosphate binding site [ion binding]; other site
339671004370	substrate (anthranilate) binding pocket [chemical binding]; other site
339671004371	product (indole) binding pocket [chemical binding]; other site
339671004372	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
339671004373	active site
339671004374	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
339671004375	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
339671004376	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
339671004377	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
339671004378	Glutamine amidotransferase class-I; Region: GATase; pfam00117
339671004379	glutamine binding [chemical binding]; other site
339671004380	catalytic triad [active]
339671004381	anthranilate synthase component I; Provisional; Region: PRK13564
339671004382	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
339671004383	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
339671004384	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
339671004385	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
339671004386	Walker A/P-loop; other site
339671004387	ATP binding site [chemical binding]; other site
339671004388	Q-loop/lid; other site
339671004389	ABC transporter signature motif; other site
339671004390	Walker B; other site
339671004391	D-loop; other site
339671004392	H-loop/switch region; other site
339671004393	inner membrane transport permease; Provisional; Region: PRK15066
339671004394	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
339671004395	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
339671004396	putative inner membrane peptidase; Provisional; Region: PRK11778
339671004397	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
339671004398	tandem repeat interface [polypeptide binding]; other site
339671004399	oligomer interface [polypeptide binding]; other site
339671004400	active site residues [active]
339671004401	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
339671004402	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
339671004403	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
339671004404	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
339671004405	ligand binding site [chemical binding]; other site
339671004406	hydrogenase 2 small subunit; Provisional; Region: PRK10468
339671004407	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
339671004408	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
339671004409	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
339671004410	4Fe-4S binding domain; Region: Fer4; cl02805
339671004411	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
339671004412	hydrogenase 2 large subunit; Provisional; Region: PRK10467
339671004413	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
339671004414	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
339671004415	putative substrate-binding site; other site
339671004416	nickel binding site [ion binding]; other site
339671004417	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
339671004418	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
339671004419	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
339671004420	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
339671004421	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
339671004422	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651
339671004423	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
339671004424	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
339671004425	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
339671004426	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
339671004427	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
339671004428	Predicted transcriptional regulators [Transcription]; Region: COG1733
339671004429	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
339671004430	putative DNA binding site [nucleotide binding]; other site
339671004431	dimerization interface [polypeptide binding]; other site
339671004432	putative Zn2+ binding site [ion binding]; other site
339671004433	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
339671004434	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
339671004435	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
339671004436	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
339671004437	putative dimer interface [polypeptide binding]; other site
339671004438	putative anticodon binding site; other site
339671004439	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
339671004440	homodimer interface [polypeptide binding]; other site
339671004441	motif 1; other site
339671004442	motif 2; other site
339671004443	active site
339671004444	motif 3; other site
339671004445	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
339671004446	homodecamer interface [polypeptide binding]; other site
339671004447	GTP cyclohydrolase I; Provisional; Region: PLN03044
339671004448	active site
339671004449	putative catalytic site residues [active]
339671004450	zinc binding site [ion binding]; other site
339671004451	GTP-CH-I/GFRP interaction surface; other site
339671004452	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
339671004453	putative deacylase active site [active]
339671004454	threonine synthase; Validated; Region: PRK06450
339671004455	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
339671004456	homodimer interface [polypeptide binding]; other site
339671004457	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671004458	catalytic residue [active]
339671004459	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
339671004460	homotrimer interaction site [polypeptide binding]; other site
339671004461	putative active site [active]
339671004462	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
339671004463	YheO-like PAS domain; Region: PAS_6; pfam08348
339671004464	HTH domain; Region: HTH_22; pfam13309
339671004465	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
339671004466	AAA domain; Region: AAA_14; pfam13173
339671004467	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
339671004468	active site residue [active]
339671004469	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
339671004470	B3/4 domain; Region: B3_4; pfam03483
339671004471	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
339671004472	Citrate transporter; Region: CitMHS; pfam03600
339671004473	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
339671004474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
339671004475	NAD(P) binding site [chemical binding]; other site
339671004476	active site
339671004477	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
339671004478	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
339671004479	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
339671004480	active site
339671004481	catalytic tetrad [active]
339671004482	Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788
339671004483	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
339671004484	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
339671004485	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
339671004486	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
339671004487	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
339671004488	Predicted membrane protein [Function unknown]; Region: COG2259
339671004489	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671004490	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671004491	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
339671004492	putative effector binding pocket; other site
339671004493	putative dimerization interface [polypeptide binding]; other site
339671004494	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
339671004495	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
339671004496	DNA binding residues [nucleotide binding]
339671004497	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
339671004498	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
339671004499	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
339671004500	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
339671004501	non-specific DNA binding site [nucleotide binding]; other site
339671004502	salt bridge; other site
339671004503	sequence-specific DNA binding site [nucleotide binding]; other site
339671004504	HipA N-terminal domain; Region: Couple_hipA; pfam13657
339671004505	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
339671004506	HipA-like N-terminal domain; Region: HipA_N; pfam07805
339671004507	HipA-like C-terminal domain; Region: HipA_C; pfam07804
339671004508	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671004509	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671004510	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
339671004511	dimerization interface [polypeptide binding]; other site
339671004512	putative effector binding pocket; other site
339671004513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671004514	Major Facilitator Superfamily; Region: MFS_1; pfam07690
339671004515	putative substrate translocation pore; other site
339671004516	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
339671004517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671004518	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
339671004519	dimerization interface [polypeptide binding]; other site
339671004520	LysE type translocator; Region: LysE; cl00565
339671004521	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
339671004522	dimerization interface [polypeptide binding]; other site
339671004523	putative DNA binding site [nucleotide binding]; other site
339671004524	putative Zn2+ binding site [ion binding]; other site
339671004525	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
339671004526	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
339671004527	catalytic residues [active]
339671004528	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
339671004529	Serine hydrolase (FSH1); Region: FSH1; pfam03959
339671004530	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
339671004531	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671004532	Major Facilitator Superfamily; Region: MFS_1; pfam07690
339671004533	putative substrate translocation pore; other site
339671004534	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
339671004535	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
339671004536	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
339671004537	active site
339671004538	Phosphotransferase enzyme family; Region: APH; pfam01636
339671004539	ATP binding site [chemical binding]; other site
339671004540	glutaredoxin 2; Provisional; Region: PRK10387
339671004541	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
339671004542	C-terminal domain interface [polypeptide binding]; other site
339671004543	GSH binding site (G-site) [chemical binding]; other site
339671004544	catalytic residues [active]
339671004545	putative dimer interface [polypeptide binding]; other site
339671004546	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
339671004547	N-terminal domain interface [polypeptide binding]; other site
339671004548	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
339671004549	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
339671004550	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
339671004551	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
339671004552	active site
339671004553	dimer interface [polypeptide binding]; other site
339671004554	motif 1; other site
339671004555	motif 2; other site
339671004556	motif 3; other site
339671004557	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
339671004558	anticodon binding site; other site
339671004559	Uncharacterized conserved protein [Function unknown]; Region: COG1434
339671004560	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
339671004561	putative active site [active]
339671004562	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
339671004563	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
339671004564	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
339671004565	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
339671004566	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
339671004567	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
339671004568	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
339671004569	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
339671004570	active site
339671004571	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
339671004572	GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195
339671004573	Transglycosylase SLT domain; Region: SLT_2; pfam13406
339671004574	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
339671004575	N-acetyl-D-glucosamine binding site [chemical binding]; other site
339671004576	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
339671004577	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
339671004578	substrate binding pocket [chemical binding]; other site
339671004579	membrane-bound complex binding site; other site
339671004580	hinge residues; other site
339671004581	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
339671004582	putative substrate binding site [chemical binding]; other site
339671004583	putative ATP binding site [chemical binding]; other site
339671004584	HemK family putative methylases; Region: hemK_fam; TIGR00536
339671004585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671004586	S-adenosylmethionine binding site [chemical binding]; other site
339671004587	hypothetical protein; Provisional; Region: PRK04946
339671004588	Smr domain; Region: Smr; pfam01713
339671004589	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
339671004590	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
339671004591	putative acyl-acceptor binding pocket; other site
339671004592	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
339671004593	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
339671004594	putative ribose interaction site [chemical binding]; other site
339671004595	putative ADP binding site [chemical binding]; other site
339671004596	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
339671004597	active site
339671004598	nucleotide binding site [chemical binding]; other site
339671004599	HIGH motif; other site
339671004600	KMSKS motif; other site
339671004601	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
339671004602	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
339671004603	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
339671004604	Walker A/P-loop; other site
339671004605	ATP binding site [chemical binding]; other site
339671004606	Q-loop/lid; other site
339671004607	ABC transporter signature motif; other site
339671004608	Walker B; other site
339671004609	D-loop; other site
339671004610	H-loop/switch region; other site
339671004611	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
339671004612	FtsX-like permease family; Region: FtsX; pfam02687
339671004613	macrolide transporter subunit MacA; Provisional; Region: PRK11578
339671004614	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
339671004615	HlyD family secretion protein; Region: HlyD_3; pfam13437
339671004616	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
339671004617	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
339671004618	active site
339671004619	metal binding site [ion binding]; metal-binding site
339671004620	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
339671004621	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
339671004622	active site
339671004623	HIGH motif; other site
339671004624	nucleotide binding site [chemical binding]; other site
339671004625	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
339671004626	KMSKS motif; other site
339671004627	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
339671004628	hypothetical protein; Provisional; Region: PRK05170
339671004629	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
339671004630	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
339671004631	glycogen branching enzyme; Provisional; Region: PRK05402
339671004632	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
339671004633	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
339671004634	active site
339671004635	catalytic site [active]
339671004636	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
339671004637	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
339671004638	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
339671004639	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
339671004640	active site
339671004641	catalytic site [active]
339671004642	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
339671004643	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
339671004644	ligand binding site; other site
339671004645	oligomer interface; other site
339671004646	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
339671004647	dimer interface [polypeptide binding]; other site
339671004648	N-terminal domain interface [polypeptide binding]; other site
339671004649	sulfate 1 binding site; other site
339671004650	glycogen synthase; Provisional; Region: glgA; PRK00654
339671004651	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
339671004652	ADP-binding pocket [chemical binding]; other site
339671004653	homodimer interface [polypeptide binding]; other site
339671004654	glycogen phosphorylase; Provisional; Region: PRK14986
339671004655	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
339671004656	homodimer interface [polypeptide binding]; other site
339671004657	active site pocket [active]
339671004658	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
339671004659	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
339671004660	Putative esterase; Region: Esterase; pfam00756
339671004661	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
339671004662	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
339671004663	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
339671004664	dimer interface [polypeptide binding]; other site
339671004665	active site
339671004666	glycine-pyridoxal phosphate binding site [chemical binding]; other site
339671004667	folate binding site [chemical binding]; other site
339671004668	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
339671004669	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
339671004670	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
339671004671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
339671004672	active site
339671004673	phosphorylation site [posttranslational modification]
339671004674	intermolecular recognition site; other site
339671004675	dimerization interface [polypeptide binding]; other site
339671004676	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
339671004677	DNA binding site [nucleotide binding]
339671004678	sensor protein QseC; Provisional; Region: PRK10337
339671004679	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
339671004680	dimer interface [polypeptide binding]; other site
339671004681	phosphorylation site [posttranslational modification]
339671004682	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
339671004683	ATP binding site [chemical binding]; other site
339671004684	Mg2+ binding site [ion binding]; other site
339671004685	G-X-G motif; other site
339671004686	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
339671004687	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
339671004688	Hemerythrin-like domain; Region: Hr-like; cd12108
339671004689	Fe binding site [ion binding]; other site
339671004690	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
339671004691	substrate binding site [chemical binding]; other site
339671004692	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
339671004693	ATP cone domain; Region: ATP-cone; pfam03477
339671004694	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
339671004695	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
339671004696	catalytic motif [active]
339671004697	Zn binding site [ion binding]; other site
339671004698	RibD C-terminal domain; Region: RibD_C; cl17279
339671004699	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
339671004700	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
339671004701	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
339671004702	protein binding site [polypeptide binding]; other site
339671004703	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
339671004704	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
339671004705	active site
339671004706	nucleophile elbow; other site
339671004707	NAD-dependent deacetylase; Provisional; Region: PRK00481
339671004708	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
339671004709	NAD+ binding site [chemical binding]; other site
339671004710	substrate binding site [chemical binding]; other site
339671004711	Zn binding site [ion binding]; other site
339671004712	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
339671004713	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
339671004714	TPP-binding site; other site
339671004715	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
339671004716	PYR/PP interface [polypeptide binding]; other site
339671004717	dimer interface [polypeptide binding]; other site
339671004718	TPP binding site [chemical binding]; other site
339671004719	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
339671004720	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
339671004721	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
339671004722	substrate binding pocket [chemical binding]; other site
339671004723	chain length determination region; other site
339671004724	substrate-Mg2+ binding site; other site
339671004725	catalytic residues [active]
339671004726	aspartate-rich region 1; other site
339671004727	active site lid residues [active]
339671004728	aspartate-rich region 2; other site
339671004729	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
339671004730	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
339671004731	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
339671004732	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
339671004733	ATP binding site [chemical binding]; other site
339671004734	substrate interface [chemical binding]; other site
339671004735	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
339671004736	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
339671004737	dimer interface [polypeptide binding]; other site
339671004738	putative functional site; other site
339671004739	putative MPT binding site; other site
339671004740	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
339671004741	putative catalytic site [active]
339671004742	putative phosphate binding site [ion binding]; other site
339671004743	active site
339671004744	metal binding site A [ion binding]; metal-binding site
339671004745	DNA binding site [nucleotide binding]
339671004746	putative AP binding site [nucleotide binding]; other site
339671004747	putative metal binding site B [ion binding]; other site
339671004748	TIGR01619 family protein; Region: hyp_HI0040
339671004749	Family of unknown function (DUF695); Region: DUF695; pfam05117
339671004750	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
339671004751	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
339671004752	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
339671004753	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
339671004754	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
339671004755	catalytic core [active]
339671004756	aminopeptidase N; Provisional; Region: pepN; PRK14015
339671004757	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
339671004758	active site
339671004759	Zn binding site [ion binding]; other site
339671004760	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
339671004761	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
339671004762	quinone interaction residues [chemical binding]; other site
339671004763	active site
339671004764	catalytic residues [active]
339671004765	FMN binding site [chemical binding]; other site
339671004766	substrate binding site [chemical binding]; other site
339671004767	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
339671004768	putative FMN binding site [chemical binding]; other site
339671004769	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
339671004770	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
339671004771	trimer interface [polypeptide binding]; other site
339671004772	active site
339671004773	substrate binding site [chemical binding]; other site
339671004774	CoA binding site [chemical binding]; other site
339671004775	Late embryogenesis abundant protein; Region: LEA_4; pfam02987
339671004776	YcgL domain; Region: YcgL; pfam05166
339671004777	Mu-like prophage protein Com; Region: Mu-like_Com; cl11540
339671004778	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
339671004779	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
339671004780	Predicted transcriptional regulator [Transcription]; Region: COG2932
339671004781	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
339671004782	sequence-specific DNA binding site [nucleotide binding]; other site
339671004783	salt bridge; other site
339671004784	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
339671004785	Catalytic site [active]
339671004786	Transcriptional regulators [Transcription]; Region: PurR; COG1609
339671004787	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
339671004788	DNA binding site [nucleotide binding]
339671004789	domain linker motif; other site
339671004790	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
339671004791	putative dimerization interface [polypeptide binding]; other site
339671004792	putative ligand binding site [chemical binding]; other site
339671004793	galactoside permease; Reviewed; Region: lacY; PRK09528
339671004794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671004795	putative substrate translocation pore; other site
339671004796	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
339671004797	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
339671004798	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
339671004799	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
339671004800	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
339671004801	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
339671004802	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
339671004803	active site
339671004804	interdomain interaction site; other site
339671004805	putative metal-binding site [ion binding]; other site
339671004806	nucleotide binding site [chemical binding]; other site
339671004807	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
339671004808	domain I; other site
339671004809	DNA binding groove [nucleotide binding]
339671004810	phosphate binding site [ion binding]; other site
339671004811	domain II; other site
339671004812	domain III; other site
339671004813	nucleotide binding site [chemical binding]; other site
339671004814	catalytic site [active]
339671004815	domain IV; other site
339671004816	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
339671004817	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
339671004818	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
339671004819	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
339671004820	exonuclease I; Provisional; Region: sbcB; PRK11779
339671004821	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
339671004822	active site
339671004823	catalytic site [active]
339671004824	substrate binding site [chemical binding]; other site
339671004825	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
339671004826	Uncharacterized conserved protein [Function unknown]; Region: COG3422
339671004827	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
339671004828	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
339671004829	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
339671004830	P-loop containing region of AAA domain; Region: AAA_29; cl17516
339671004831	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
339671004832	condesin subunit E; Provisional; Region: PRK05256
339671004833	condesin subunit F; Provisional; Region: PRK05260
339671004834	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
339671004835	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
339671004836	Ligand Binding Site [chemical binding]; other site
339671004837	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
339671004838	ATP cone domain; Region: ATP-cone; pfam03477
339671004839	Class III ribonucleotide reductase; Region: RNR_III; cd01675
339671004840	effector binding site; other site
339671004841	active site
339671004842	Zn binding site [ion binding]; other site
339671004843	glycine loop; other site
339671004844	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
339671004845	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
339671004846	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671004847	FeS/SAM binding site; other site
339671004848	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671004849	active site
339671004850	motif I; other site
339671004851	motif II; other site
339671004852	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
339671004853	active site
339671004854	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
339671004855	putative active site [active]
339671004856	catalytic residue [active]
339671004857	GTP-binding protein YchF; Reviewed; Region: PRK09601
339671004858	YchF GTPase; Region: YchF; cd01900
339671004859	G1 box; other site
339671004860	GTP/Mg2+ binding site [chemical binding]; other site
339671004861	Switch I region; other site
339671004862	G2 box; other site
339671004863	Switch II region; other site
339671004864	G3 box; other site
339671004865	G4 box; other site
339671004866	G5 box; other site
339671004867	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
339671004868	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
339671004869	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
339671004870	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
339671004871	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
339671004872	NlpC/P60 family; Region: NLPC_P60; pfam00877
339671004873	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
339671004874	IHF dimer interface [polypeptide binding]; other site
339671004875	IHF - DNA interface [nucleotide binding]; other site
339671004876	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
339671004877	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
339671004878	putative tRNA-binding site [nucleotide binding]; other site
339671004879	B3/4 domain; Region: B3_4; pfam03483
339671004880	tRNA synthetase B5 domain; Region: B5; smart00874
339671004881	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
339671004882	dimer interface [polypeptide binding]; other site
339671004883	motif 1; other site
339671004884	motif 3; other site
339671004885	motif 2; other site
339671004886	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
339671004887	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
339671004888	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
339671004889	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
339671004890	dimer interface [polypeptide binding]; other site
339671004891	motif 1; other site
339671004892	active site
339671004893	motif 2; other site
339671004894	motif 3; other site
339671004895	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
339671004896	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
339671004897	active site
339671004898	substrate binding site [chemical binding]; other site
339671004899	metal binding site [ion binding]; metal-binding site
339671004900	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
339671004901	dihydropteroate synthase; Region: DHPS; TIGR01496
339671004902	substrate binding pocket [chemical binding]; other site
339671004903	dimer interface [polypeptide binding]; other site
339671004904	inhibitor binding site; inhibition site
339671004905	sugar efflux transporter B; Provisional; Region: PRK15011
339671004906	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671004907	putative substrate translocation pore; other site
339671004908	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
339671004909	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
339671004910	active site
339671004911	dimer interface [polypeptide binding]; other site
339671004912	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
339671004913	dimer interface [polypeptide binding]; other site
339671004914	active site
339671004915	alanine racemase; Reviewed; Region: alr; PRK00053
339671004916	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
339671004917	active site
339671004918	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
339671004919	substrate binding site [chemical binding]; other site
339671004920	catalytic residues [active]
339671004921	dimer interface [polypeptide binding]; other site
339671004922	replicative DNA helicase; Validated; Region: PRK06904
339671004923	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
339671004924	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
339671004925	Walker A motif; other site
339671004926	ATP binding site [chemical binding]; other site
339671004927	Walker B motif; other site
339671004928	DNA binding loops [nucleotide binding]
339671004929	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
339671004930	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
339671004931	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
339671004932	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
339671004933	FtsX-like permease family; Region: FtsX; pfam02687
339671004934	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
339671004935	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
339671004936	Walker A/P-loop; other site
339671004937	ATP binding site [chemical binding]; other site
339671004938	Q-loop/lid; other site
339671004939	ABC transporter signature motif; other site
339671004940	Walker B; other site
339671004941	D-loop; other site
339671004942	H-loop/switch region; other site
339671004943	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
339671004944	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
339671004945	FtsX-like permease family; Region: FtsX; pfam02687
339671004946	glycerate dehydrogenase; Provisional; Region: PRK06932
339671004947	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
339671004948	putative ligand binding site [chemical binding]; other site
339671004949	putative NAD binding site [chemical binding]; other site
339671004950	catalytic site [active]
339671004951	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
339671004952	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
339671004953	Uncharacterized conserved protein [Function unknown]; Region: COG2912
339671004954	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
339671004955	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
339671004956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671004957	S-adenosylmethionine binding site [chemical binding]; other site
339671004958	RDD family; Region: RDD; pfam06271
339671004959	peptide chain release factor 1; Validated; Region: prfA; PRK00591
339671004960	This domain is found in peptide chain release factors; Region: PCRF; smart00937
339671004961	RF-1 domain; Region: RF-1; pfam00472
339671004962	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
339671004963	catalytic core [active]
339671004964	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
339671004965	dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005
339671004966	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
339671004967	Dak1 domain; Region: Dak1; pfam02733
339671004968	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
339671004969	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
339671004970	Coenzyme A binding pocket [chemical binding]; other site
339671004971	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
339671004972	active site 1 [active]
339671004973	dimer interface [polypeptide binding]; other site
339671004974	active site 2 [active]
339671004975	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
339671004976	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
339671004977	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
339671004978	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
339671004979	DNA-binding site [nucleotide binding]; DNA binding site
339671004980	RNA-binding motif; other site
339671004981	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
339671004982	23S rRNA binding site [nucleotide binding]; other site
339671004983	L21 binding site [polypeptide binding]; other site
339671004984	L13 binding site [polypeptide binding]; other site
339671004985	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
339671004986	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
339671004987	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
339671004988	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
339671004989	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
339671004990	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
339671004991	Protein of unknown function, DUF462; Region: DUF462; cl01190
339671004992	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
339671004993	active site
339671004994	DNA polymerase IV; Validated; Region: PRK02406
339671004995	DNA binding site [nucleotide binding]
339671004996	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
339671004997	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
339671004998	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
339671004999	putative active site [active]
339671005000	putative metal-binding site [ion binding]; other site
339671005001	Predicted membrane protein [Function unknown]; Region: COG2431
339671005002	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
339671005003	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
339671005004	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
339671005005	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
339671005006	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
339671005007	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
339671005008	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
339671005009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671005010	Walker A motif; other site
339671005011	ATP binding site [chemical binding]; other site
339671005012	Walker B motif; other site
339671005013	arginine finger; other site
339671005014	Peptidase family M41; Region: Peptidase_M41; pfam01434
339671005015	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
339671005016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671005017	S-adenosylmethionine binding site [chemical binding]; other site
339671005018	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
339671005019	dimer interface [polypeptide binding]; other site
339671005020	active site
339671005021	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
339671005022	LppC putative lipoprotein; Region: LppC; pfam04348
339671005023	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
339671005024	putative ligand binding site [chemical binding]; other site
339671005025	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
339671005026	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
339671005027	putative SAM binding site [chemical binding]; other site
339671005028	putative homodimer interface [polypeptide binding]; other site
339671005029	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
339671005030	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
339671005031	DNA binding site [nucleotide binding]
339671005032	domain linker motif; other site
339671005033	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
339671005034	dimerization interface [polypeptide binding]; other site
339671005035	ligand binding site [chemical binding]; other site
339671005036	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
339671005037	ATP cone domain; Region: ATP-cone; pfam03477
339671005038	Class I ribonucleotide reductase; Region: RNR_I; cd01679
339671005039	active site
339671005040	dimer interface [polypeptide binding]; other site
339671005041	catalytic residues [active]
339671005042	effector binding site; other site
339671005043	R2 peptide binding site; other site
339671005044	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
339671005045	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
339671005046	Na binding site [ion binding]; other site
339671005047	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
339671005048	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
339671005049	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
339671005050	active site
339671005051	intersubunit interface [polypeptide binding]; other site
339671005052	catalytic residue [active]
339671005053	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
339671005054	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
339671005055	substrate binding site [chemical binding]; other site
339671005056	ATP binding site [chemical binding]; other site
339671005057	hypothetical protein; Provisional; Region: PRK09273
339671005058	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
339671005059	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
339671005060	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
339671005061	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
339671005062	NADP binding site [chemical binding]; other site
339671005063	homodimer interface [polypeptide binding]; other site
339671005064	active site
339671005065	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
339671005066	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
339671005067	Bacterial transcriptional regulator; Region: IclR; pfam01614
339671005068	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
339671005069	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
339671005070	trimer interface [polypeptide binding]; other site
339671005071	eyelet of channel; other site
339671005072	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
339671005073	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
339671005074	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671005075	catalytic residue [active]
339671005076	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
339671005077	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
339671005078	substrate binding site [chemical binding]; other site
339671005079	active site
339671005080	catalytic residues [active]
339671005081	heterodimer interface [polypeptide binding]; other site
339671005082	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
339671005083	dimer interface [polypeptide binding]; other site
339671005084	putative radical transfer pathway; other site
339671005085	diiron center [ion binding]; other site
339671005086	tyrosyl radical; other site
339671005087	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
339671005088	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
339671005089	catalytic loop [active]
339671005090	iron binding site [ion binding]; other site
339671005091	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
339671005092	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
339671005093	transmembrane helices; other site
339671005094	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
339671005095	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
339671005096	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
339671005097	LysE type translocator; Region: LysE; cl00565
339671005098	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
339671005099	tetramer interfaces [polypeptide binding]; other site
339671005100	binuclear metal-binding site [ion binding]; other site
339671005101	thiamine monophosphate kinase; Provisional; Region: PRK05731
339671005102	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
339671005103	ATP binding site [chemical binding]; other site
339671005104	dimerization interface [polypeptide binding]; other site
339671005105	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
339671005106	putative RNA binding site [nucleotide binding]; other site
339671005107	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
339671005108	homopentamer interface [polypeptide binding]; other site
339671005109	active site
339671005110	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
339671005111	aromatic amino acid transport protein; Region: araaP; TIGR00837
339671005112	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
339671005113	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
339671005114	metal binding triad; other site
339671005115	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
339671005116	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
339671005117	metal binding triad; other site
339671005118	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
339671005119	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
339671005120	stringent starvation protein A; Provisional; Region: sspA; PRK09481
339671005121	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
339671005122	C-terminal domain interface [polypeptide binding]; other site
339671005123	putative GSH binding site (G-site) [chemical binding]; other site
339671005124	dimer interface [polypeptide binding]; other site
339671005125	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
339671005126	dimer interface [polypeptide binding]; other site
339671005127	N-terminal domain interface [polypeptide binding]; other site
339671005128	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
339671005129	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
339671005130	23S rRNA interface [nucleotide binding]; other site
339671005131	L3 interface [polypeptide binding]; other site
339671005132	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
339671005133	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
339671005134	inhibitor-cofactor binding pocket; inhibition site
339671005135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671005136	catalytic residue [active]
339671005137	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
339671005138	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671005139	catalytic residue [active]
339671005140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
339671005141	Protein of unknown function (DUF1043); Region: DUF1043; pfam06295
339671005142	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
339671005143	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
339671005144	dimerization interface [polypeptide binding]; other site
339671005145	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
339671005146	ATP binding site [chemical binding]; other site
339671005147	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
339671005148	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
339671005149	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
339671005150	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
339671005151	dimerization interface [polypeptide binding]; other site
339671005152	active site
339671005153	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
339671005154	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
339671005155	active site
339671005156	fructokinase; Reviewed; Region: PRK09557
339671005157	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
339671005158	nucleotide binding site [chemical binding]; other site
339671005159	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
339671005160	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
339671005161	substrate binding site [chemical binding]; other site
339671005162	multimerization interface [polypeptide binding]; other site
339671005163	ATP binding site [chemical binding]; other site
339671005164	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
339671005165	dimer interface [polypeptide binding]; other site
339671005166	substrate binding site [chemical binding]; other site
339671005167	ATP binding site [chemical binding]; other site
339671005168	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
339671005169	thiamine phosphate binding site [chemical binding]; other site
339671005170	active site
339671005171	pyrophosphate binding site [ion binding]; other site
339671005172	ornithine carbamoyltransferase; Provisional; Region: PRK01713
339671005173	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
339671005174	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
339671005175	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
339671005176	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
339671005177	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
339671005178	catalytic residues [active]
339671005179	alpha helical domain; other site
339671005180	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
339671005181	DHH family; Region: DHH; pfam01368
339671005182	DHHA1 domain; Region: DHHA1; pfam02272
339671005183	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
339671005184	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
339671005185	dimerization domain [polypeptide binding]; other site
339671005186	dimer interface [polypeptide binding]; other site
339671005187	catalytic residues [active]
339671005188	peptide chain release factor 2; Validated; Region: prfB; PRK00578
339671005189	This domain is found in peptide chain release factors; Region: PCRF; smart00937
339671005190	RF-1 domain; Region: RF-1; pfam00472
339671005191	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
339671005192	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
339671005193	dimer interface [polypeptide binding]; other site
339671005194	putative anticodon binding site; other site
339671005195	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
339671005196	motif 1; other site
339671005197	active site
339671005198	motif 2; other site
339671005199	motif 3; other site
339671005200	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
339671005201	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
339671005202	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
339671005203	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
339671005204	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
339671005205	DNA binding residues [nucleotide binding]
339671005206	ferredoxin-type protein NapF; Region: napF; TIGR00402
339671005207	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
339671005208	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
339671005209	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
339671005210	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
339671005211	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
339671005212	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
339671005213	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
339671005214	putative [Fe4-S4] binding site [ion binding]; other site
339671005215	putative molybdopterin cofactor binding site [chemical binding]; other site
339671005216	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
339671005217	putative molybdopterin cofactor binding site; other site
339671005218	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
339671005219	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
339671005220	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
339671005221	putative [Fe4-S4] binding site [ion binding]; other site
339671005222	putative molybdopterin cofactor binding site [chemical binding]; other site
339671005223	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
339671005224	putative molybdopterin cofactor binding site; other site
339671005225	hypothetical protein; Provisional; Region: PRK11622
339671005226	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
339671005227	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
339671005228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671005229	dimer interface [polypeptide binding]; other site
339671005230	conserved gate region; other site
339671005231	putative PBP binding loops; other site
339671005232	ABC-ATPase subunit interface; other site
339671005233	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
339671005234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671005235	dimer interface [polypeptide binding]; other site
339671005236	conserved gate region; other site
339671005237	putative PBP binding loops; other site
339671005238	ABC-ATPase subunit interface; other site
339671005239	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
339671005240	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671005241	Walker A/P-loop; other site
339671005242	ATP binding site [chemical binding]; other site
339671005243	Q-loop/lid; other site
339671005244	ABC transporter signature motif; other site
339671005245	Walker B; other site
339671005246	D-loop; other site
339671005247	H-loop/switch region; other site
339671005248	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
339671005249	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
339671005250	FMN binding site [chemical binding]; other site
339671005251	substrate binding site [chemical binding]; other site
339671005252	putative catalytic residue [active]
339671005253	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
339671005254	Uncharacterized conserved protein [Function unknown]; Region: COG1359
339671005255	Uncharacterized conserved protein [Function unknown]; Region: COG1359
339671005256	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
339671005257	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
339671005258	NAD(P) binding site [chemical binding]; other site
339671005259	active site
339671005260	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
339671005261	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
339671005262	active site
339671005263	catalytic tetrad [active]
339671005264	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671005265	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671005266	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
339671005267	dimerization interface [polypeptide binding]; other site
339671005268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671005269	Archaeal ATPase; Region: Arch_ATPase; pfam01637
339671005270	Walker A motif; other site
339671005271	ATP binding site [chemical binding]; other site
339671005272	Walker B motif; other site
339671005273	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
339671005274	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
339671005275	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
339671005276	putative NAD(P) binding site [chemical binding]; other site
339671005277	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
339671005278	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671005279	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671005280	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
339671005281	putative effector binding pocket; other site
339671005282	dimerization interface [polypeptide binding]; other site
339671005283	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671005284	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671005285	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
339671005286	putative effector binding pocket; other site
339671005287	dimerization interface [polypeptide binding]; other site
339671005288	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
339671005289	dimer interface [polypeptide binding]; other site
339671005290	FMN binding site [chemical binding]; other site
339671005291	translation initiation factor Sui1; Validated; Region: PRK06824
339671005292	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
339671005293	putative rRNA binding site [nucleotide binding]; other site
339671005294	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
339671005295	active site
339671005296	dimer interface [polypeptide binding]; other site
339671005297	tetratricopeptide repeat protein; Provisional; Region: PRK11788
339671005298	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
339671005299	binding surface
339671005300	TPR motif; other site
339671005301	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
339671005302	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
339671005303	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
339671005304	IHF dimer interface [polypeptide binding]; other site
339671005305	IHF - DNA interface [nucleotide binding]; other site
339671005306	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
339671005307	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
339671005308	RNA binding site [nucleotide binding]; other site
339671005309	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
339671005310	RNA binding site [nucleotide binding]; other site
339671005311	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
339671005312	RNA binding site [nucleotide binding]; other site
339671005313	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
339671005314	RNA binding site [nucleotide binding]; other site
339671005315	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
339671005316	RNA binding site [nucleotide binding]; other site
339671005317	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
339671005318	RNA binding site [nucleotide binding]; other site
339671005319	cytidylate kinase; Provisional; Region: cmk; PRK00023
339671005320	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
339671005321	CMP-binding site; other site
339671005322	The sites determining sugar specificity; other site
339671005323	Protein of unknown function (DUF535); Region: DUF535; pfam04393
339671005324	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
339671005325	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
339671005326	N-acetyl-D-glucosamine binding site [chemical binding]; other site
339671005327	catalytic residue [active]
339671005328	Trp operon repressor; Provisional; Region: PRK01381
339671005329	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
339671005330	Transglycosylase; Region: Transgly; cl17702
339671005331	Predicted permeases [General function prediction only]; Region: RarD; COG2962
339671005332	EamA-like transporter family; Region: EamA; pfam00892
339671005333	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
339671005334	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
339671005335	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
339671005336	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
339671005337	molybdenum-pterin binding domain; Region: Mop; TIGR00638
339671005338	TOBE domain; Region: TOBE_2; pfam08402
339671005339	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
339671005340	CoenzymeA binding site [chemical binding]; other site
339671005341	subunit interaction site [polypeptide binding]; other site
339671005342	PHB binding site; other site
339671005343	ferrochelatase; Reviewed; Region: hemH; PRK00035
339671005344	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
339671005345	C-terminal domain interface [polypeptide binding]; other site
339671005346	active site
339671005347	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
339671005348	active site
339671005349	N-terminal domain interface [polypeptide binding]; other site
339671005350	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
339671005351	CoA binding domain; Region: CoA_binding; pfam02629
339671005352	CoA-ligase; Region: Ligase_CoA; pfam00549
339671005353	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
339671005354	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
339671005355	CoA-ligase; Region: Ligase_CoA; pfam00549
339671005356	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
339671005357	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
339671005358	E3 interaction surface; other site
339671005359	lipoyl attachment site [posttranslational modification]; other site
339671005360	e3 binding domain; Region: E3_binding; pfam02817
339671005361	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
339671005362	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
339671005363	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
339671005364	TPP-binding site [chemical binding]; other site
339671005365	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
339671005366	PYR/PP interface [polypeptide binding]; other site
339671005367	dimer interface [polypeptide binding]; other site
339671005368	TPP binding site [chemical binding]; other site
339671005369	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
339671005370	transmembrane helices; other site
339671005371	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
339671005372	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
339671005373	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
339671005374	prephenate dehydrogenase; Validated; Region: PRK08507
339671005375	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
339671005376	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
339671005377	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
339671005378	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
339671005379	tandem repeat interface [polypeptide binding]; other site
339671005380	oligomer interface [polypeptide binding]; other site
339671005381	active site residues [active]
339671005382	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
339671005383	tandem repeat interface [polypeptide binding]; other site
339671005384	oligomer interface [polypeptide binding]; other site
339671005385	active site residues [active]
339671005386	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
339671005387	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
339671005388	ATP-grasp domain; Region: ATP-grasp; pfam02222
339671005389	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
339671005390	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
339671005391	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671005392	homodimer interface [polypeptide binding]; other site
339671005393	catalytic residue [active]
339671005394	triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional; Region: PRK14905
339671005395	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
339671005396	substrate binding site [chemical binding]; other site
339671005397	dimer interface [polypeptide binding]; other site
339671005398	catalytic triad [active]
339671005399	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
339671005400	active site turn [active]
339671005401	phosphorylation site [posttranslational modification]
339671005402	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
339671005403	DctM-like transporters; Region: DctM; pfam06808
339671005404	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
339671005405	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
339671005406	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
339671005407	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
339671005408	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
339671005409	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
339671005410	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
339671005411	DNA binding residues [nucleotide binding]
339671005412	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
339671005413	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
339671005414	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
339671005415	Amidohydrolase; Region: Amidohydro_2; pfam04909
339671005416	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671005417	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
339671005418	putative substrate translocation pore; other site
339671005419	DAK2 domain; Region: Dak2; cl03685
339671005420	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
339671005421	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
339671005422	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
339671005423	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
339671005424	oligopeptidase A; Provisional; Region: PRK10911
339671005425	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
339671005426	active site
339671005427	Zn binding site [ion binding]; other site
339671005428	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
339671005429	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
339671005430	thioredoxin reductase; Provisional; Region: PRK10262
339671005431	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
339671005432	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
339671005433	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
339671005434	catalytic loop [active]
339671005435	iron binding site [ion binding]; other site
339671005436	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
339671005437	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
339671005438	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
339671005439	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
339671005440	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
339671005441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
339671005442	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
339671005443	Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995
339671005444	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
339671005445	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
339671005446	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
339671005447	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
339671005448	triosephosphate isomerase; Provisional; Region: PRK14565
339671005449	substrate binding site [chemical binding]; other site
339671005450	dimer interface [polypeptide binding]; other site
339671005451	catalytic triad [active]
339671005452	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
339671005453	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
339671005454	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
339671005455	amphipathic channel; other site
339671005456	Asn-Pro-Ala signature motifs; other site
339671005457	glycerol kinase; Provisional; Region: glpK; PRK00047
339671005458	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
339671005459	N- and C-terminal domain interface [polypeptide binding]; other site
339671005460	active site
339671005461	MgATP binding site [chemical binding]; other site
339671005462	catalytic site [active]
339671005463	metal binding site [ion binding]; metal-binding site
339671005464	glycerol binding site [chemical binding]; other site
339671005465	homotetramer interface [polypeptide binding]; other site
339671005466	homodimer interface [polypeptide binding]; other site
339671005467	FBP binding site [chemical binding]; other site
339671005468	protein IIAGlc interface [polypeptide binding]; other site
339671005469	hypothetical protein; Validated; Region: PRK01777
339671005470	Predicted membrane protein [Function unknown]; Region: COG2510
339671005471	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
339671005472	Ferritin-like domain; Region: Ferritin; pfam00210
339671005473	ferroxidase diiron center [ion binding]; other site
339671005474	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
339671005475	Ferritin-like domain; Region: Ferritin; pfam00210
339671005476	ferroxidase diiron center [ion binding]; other site
339671005477	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
339671005478	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
339671005479	ligand binding site [chemical binding]; other site
339671005480	flexible hinge region; other site
339671005481	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
339671005482	putative switch regulator; other site
339671005483	non-specific DNA interactions [nucleotide binding]; other site
339671005484	DNA binding site [nucleotide binding]
339671005485	sequence specific DNA binding site [nucleotide binding]; other site
339671005486	putative cAMP binding site [chemical binding]; other site
339671005487	universal stress protein UspE; Provisional; Region: PRK11175
339671005488	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
339671005489	Ligand Binding Site [chemical binding]; other site
339671005490	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
339671005491	Ligand Binding Site [chemical binding]; other site
339671005492	malate dehydrogenase; Provisional; Region: PRK05086
339671005493	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
339671005494	NAD binding site [chemical binding]; other site
339671005495	dimerization interface [polypeptide binding]; other site
339671005496	Substrate binding site [chemical binding]; other site
339671005497	arginine repressor; Provisional; Region: PRK05066
339671005498	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
339671005499	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
339671005500	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
339671005501	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
339671005502	NAD(P) binding site [chemical binding]; other site
339671005503	active site
339671005504	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
339671005505	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
339671005506	Zn2+ binding site [ion binding]; other site
339671005507	Mg2+ binding site [ion binding]; other site
339671005508	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
339671005509	LrgB-like family; Region: LrgB; cl00596
339671005510	hypothetical protein; Provisional; Region: PRK01821
339671005511	Staphylococcal nuclease homologues; Region: SNc; smart00318
339671005512	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
339671005513	Catalytic site; other site
339671005514	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
339671005515	Aminotransferase class-V; Region: Aminotran_5; pfam00266
339671005516	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
339671005517	catalytic residue [active]
339671005518	Fe-S metabolism associated domain; Region: SufE; cl00951
339671005519	Predicted peptidase [General function prediction only]; Region: COG4099
339671005520	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
339671005521	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
339671005522	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
339671005523	phosphate binding site [ion binding]; other site
339671005524	putative substrate binding pocket [chemical binding]; other site
339671005525	dimer interface [polypeptide binding]; other site
339671005526	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
339671005527	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
339671005528	homodimer interface [polypeptide binding]; other site
339671005529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671005530	substrate-cofactor binding pocket; other site
339671005531	catalytic residue [active]
339671005532	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
339671005533	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
339671005534	NAD(P) binding site [chemical binding]; other site
339671005535	active site
339671005536	Acylphosphatase; Region: Acylphosphatase; pfam00708
339671005537	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
339671005538	HypF finger; Region: zf-HYPF; pfam07503
339671005539	HypF finger; Region: zf-HYPF; pfam07503
339671005540	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
339671005541	MarR family; Region: MarR_2; pfam12802
339671005542	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
339671005543	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
339671005544	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
339671005545	Domain of unknown function (DUF333); Region: DUF333; pfam03891
339671005546	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
339671005547	catalytic site [active]
339671005548	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671005549	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671005550	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
339671005551	dimerization interface [polypeptide binding]; other site
339671005552	putative effector binding pocket; other site
339671005553	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
339671005554	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671005555	Walker A/P-loop; other site
339671005556	ATP binding site [chemical binding]; other site
339671005557	Q-loop/lid; other site
339671005558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671005559	ABC transporter signature motif; other site
339671005560	Walker B; other site
339671005561	D-loop; other site
339671005562	H-loop/switch region; other site
339671005563	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671005564	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
339671005565	Walker A/P-loop; other site
339671005566	ATP binding site [chemical binding]; other site
339671005567	Q-loop/lid; other site
339671005568	ABC transporter signature motif; other site
339671005569	Walker B; other site
339671005570	D-loop; other site
339671005571	H-loop/switch region; other site
339671005572	Protein of unknown function DUF45; Region: DUF45; pfam01863
339671005573	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
339671005574	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
339671005575	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
339671005576	ATP binding site [chemical binding]; other site
339671005577	putative Mg++ binding site [ion binding]; other site
339671005578	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
339671005579	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
339671005580	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
339671005581	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
339671005582	HsdM N-terminal domain; Region: HsdM_N; pfam12161
339671005583	Methyltransferase domain; Region: Methyltransf_26; pfam13659
339671005584	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
339671005585	BRO family, N-terminal domain; Region: Bro-N; pfam02498
339671005586	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
339671005587	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
339671005588	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
339671005589	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
339671005590	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
339671005591	nucleophilic elbow; other site
339671005592	catalytic triad; other site
339671005593	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
339671005594	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
339671005595	putative C-terminal domain interface [polypeptide binding]; other site
339671005596	putative GSH binding site (G-site) [chemical binding]; other site
339671005597	putative dimer interface [polypeptide binding]; other site
339671005598	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
339671005599	N-terminal domain interface [polypeptide binding]; other site
339671005600	dimer interface [polypeptide binding]; other site
339671005601	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
339671005602	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
339671005603	putative C-terminal domain interface [polypeptide binding]; other site
339671005604	putative GSH binding site (G-site) [chemical binding]; other site
339671005605	putative dimer interface [polypeptide binding]; other site
339671005606	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
339671005607	N-terminal domain interface [polypeptide binding]; other site
339671005608	dimer interface [polypeptide binding]; other site
339671005609	substrate binding pocket (H-site) [chemical binding]; other site
339671005610	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
339671005611	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
339671005612	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
339671005613	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
339671005614	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
339671005615	putative FMN binding site [chemical binding]; other site
339671005616	Protein of unknown function (DUF419); Region: DUF419; pfam04237
339671005617	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
339671005618	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
339671005619	dinuclear metal binding motif [ion binding]; other site
339671005620	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
339671005621	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
339671005622	putative active site [active]
339671005623	putative FMN binding site [chemical binding]; other site
339671005624	putative substrate binding site [chemical binding]; other site
339671005625	putative catalytic residue [active]
339671005626	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
339671005627	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
339671005628	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
339671005629	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
339671005630	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
339671005631	catalytic residues [active]
339671005632	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
339671005633	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
339671005634	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
339671005635	FMN binding site [chemical binding]; other site
339671005636	substrate binding site [chemical binding]; other site
339671005637	putative catalytic residue [active]
339671005638	transcriptional regulator; Provisional; Region: PRK10632
339671005639	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671005640	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
339671005641	putative effector binding pocket; other site
339671005642	putative dimerization interface [polypeptide binding]; other site
339671005643	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
339671005644	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
339671005645	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
339671005646	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
339671005647	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
339671005648	propionate/acetate kinase; Provisional; Region: PRK12379
339671005649	phosphate acetyltransferase; Reviewed; Region: PRK05632
339671005650	DRTGG domain; Region: DRTGG; pfam07085
339671005651	phosphate acetyltransferase; Region: pta; TIGR00651
339671005652	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
339671005653	Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470
339671005654	Predicted membrane protein [Function unknown]; Region: COG4393
339671005655	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
339671005656	Uncharacterized conserved protein [Function unknown]; Region: COG3350
339671005657	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
339671005658	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
339671005659	FtsX-like permease family; Region: FtsX; pfam02687
339671005660	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
339671005661	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
339671005662	FtsX-like permease family; Region: FtsX; pfam02687
339671005663	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
339671005664	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
339671005665	Walker A/P-loop; other site
339671005666	ATP binding site [chemical binding]; other site
339671005667	Q-loop/lid; other site
339671005668	ABC transporter signature motif; other site
339671005669	Walker B; other site
339671005670	D-loop; other site
339671005671	H-loop/switch region; other site
339671005672	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
339671005673	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
339671005674	catalytic residues [active]
339671005675	Cytochrome c; Region: Cytochrom_C; cl11414
339671005676	KpsF/GutQ family protein; Region: kpsF; TIGR00393
339671005677	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
339671005678	putative active site [active]
339671005679	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
339671005680	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
339671005681	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671005682	active site
339671005683	motif I; other site
339671005684	motif II; other site
339671005685	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
339671005686	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
339671005687	MoaE homodimer interface [polypeptide binding]; other site
339671005688	MoaD interaction [polypeptide binding]; other site
339671005689	active site residues [active]
339671005690	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
339671005691	MoaE interaction surface [polypeptide binding]; other site
339671005692	MoeB interaction surface [polypeptide binding]; other site
339671005693	thiocarboxylated glycine; other site
339671005694	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
339671005695	trimer interface [polypeptide binding]; other site
339671005696	dimer interface [polypeptide binding]; other site
339671005697	putative active site [active]
339671005698	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
339671005699	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671005700	FeS/SAM binding site; other site
339671005701	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
339671005702	Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687
339671005703	AzlC protein; Region: AzlC; cl00570
339671005704	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
339671005705	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671005706	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
339671005707	putative dimerization interface [polypeptide binding]; other site
339671005708	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
339671005709	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
339671005710	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
339671005711	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
339671005712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671005713	dimer interface [polypeptide binding]; other site
339671005714	conserved gate region; other site
339671005715	putative PBP binding loops; other site
339671005716	ABC-ATPase subunit interface; other site
339671005717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671005718	dimer interface [polypeptide binding]; other site
339671005719	conserved gate region; other site
339671005720	putative PBP binding loops; other site
339671005721	ABC-ATPase subunit interface; other site
339671005722	ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432
339671005723	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
339671005724	Walker A/P-loop; other site
339671005725	ATP binding site [chemical binding]; other site
339671005726	Q-loop/lid; other site
339671005727	ABC transporter signature motif; other site
339671005728	Walker B; other site
339671005729	D-loop; other site
339671005730	H-loop/switch region; other site
339671005731	TOBE domain; Region: TOBE_2; pfam08402
339671005732	argininosuccinate lyase; Provisional; Region: PRK06705
339671005733	sulfite reductase subunit beta; Provisional; Region: PRK13504
339671005734	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
339671005735	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
339671005736	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
339671005737	Flavodoxin; Region: Flavodoxin_1; pfam00258
339671005738	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
339671005739	FAD binding pocket [chemical binding]; other site
339671005740	FAD binding motif [chemical binding]; other site
339671005741	catalytic residues [active]
339671005742	NAD binding pocket [chemical binding]; other site
339671005743	phosphate binding motif [ion binding]; other site
339671005744	beta-alpha-beta structure motif; other site
339671005745	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
339671005746	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
339671005747	CysD dimerization site [polypeptide binding]; other site
339671005748	G1 box; other site
339671005749	putative GEF interaction site [polypeptide binding]; other site
339671005750	GTP/Mg2+ binding site [chemical binding]; other site
339671005751	Switch I region; other site
339671005752	G2 box; other site
339671005753	G3 box; other site
339671005754	Switch II region; other site
339671005755	G4 box; other site
339671005756	G5 box; other site
339671005757	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
339671005758	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
339671005759	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
339671005760	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
339671005761	Active Sites [active]
339671005762	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
339671005763	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
339671005764	Active Sites [active]
339671005765	siroheme synthase; Provisional; Region: cysG; PRK10637
339671005766	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
339671005767	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
339671005768	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
339671005769	active site
339671005770	SAM binding site [chemical binding]; other site
339671005771	homodimer interface [polypeptide binding]; other site
339671005772	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
339671005773	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
339671005774	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
339671005775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671005776	dimer interface [polypeptide binding]; other site
339671005777	conserved gate region; other site
339671005778	putative PBP binding loops; other site
339671005779	ABC-ATPase subunit interface; other site
339671005780	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
339671005781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671005782	dimer interface [polypeptide binding]; other site
339671005783	conserved gate region; other site
339671005784	putative PBP binding loops; other site
339671005785	ABC-ATPase subunit interface; other site
339671005786	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
339671005787	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
339671005788	Walker A/P-loop; other site
339671005789	ATP binding site [chemical binding]; other site
339671005790	Q-loop/lid; other site
339671005791	ABC transporter signature motif; other site
339671005792	Walker B; other site
339671005793	D-loop; other site
339671005794	H-loop/switch region; other site
339671005795	TOBE-like domain; Region: TOBE_3; pfam12857
339671005796	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
339671005797	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
339671005798	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
339671005799	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671005800	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
339671005801	dimerization interface [polypeptide binding]; other site
339671005802	substrate binding pocket [chemical binding]; other site
339671005803	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
339671005804	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
339671005805	homodimer interface [polypeptide binding]; other site
339671005806	substrate-cofactor binding pocket; other site
339671005807	catalytic residue [active]
339671005808	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
339671005809	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
339671005810	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671005811	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
339671005812	substrate binding site [chemical binding]; other site
339671005813	dimerization interface [polypeptide binding]; other site
339671005814	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
339671005815	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
339671005816	RNA binding surface [nucleotide binding]; other site
339671005817	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
339671005818	probable active site [active]
339671005819	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
339671005820	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
339671005821	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
339671005822	DNA binding site [nucleotide binding]
339671005823	domain linker motif; other site
339671005824	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
339671005825	putative ligand binding site [chemical binding]; other site
339671005826	putative dimerization interface [polypeptide binding]; other site
339671005827	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
339671005828	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
339671005829	catalytic loop [active]
339671005830	iron binding site [ion binding]; other site
339671005831	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
339671005832	4Fe-4S binding domain; Region: Fer4; pfam00037
339671005833	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
339671005834	[4Fe-4S] binding site [ion binding]; other site
339671005835	molybdopterin cofactor binding site; other site
339671005836	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
339671005837	molybdopterin cofactor binding site; other site
339671005838	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
339671005839	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
339671005840	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
339671005841	DNA topoisomerase III; Provisional; Region: PRK07726
339671005842	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
339671005843	active site
339671005844	putative interdomain interaction site [polypeptide binding]; other site
339671005845	putative metal-binding site [ion binding]; other site
339671005846	putative nucleotide binding site [chemical binding]; other site
339671005847	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
339671005848	domain I; other site
339671005849	DNA binding groove [nucleotide binding]
339671005850	phosphate binding site [ion binding]; other site
339671005851	domain II; other site
339671005852	domain III; other site
339671005853	nucleotide binding site [chemical binding]; other site
339671005854	catalytic site [active]
339671005855	domain IV; other site
339671005856	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
339671005857	amidophosphoribosyltransferase; Provisional; Region: PRK09246
339671005858	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
339671005859	active site
339671005860	tetramer interface [polypeptide binding]; other site
339671005861	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
339671005862	active site
339671005863	Colicin V production protein; Region: Colicin_V; cl00567
339671005864	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
339671005865	hypothetical protein; Provisional; Region: PRK01816
339671005866	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
339671005867	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
339671005868	dimerization interface 3.5A [polypeptide binding]; other site
339671005869	active site
339671005870	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
339671005871	5S rRNA interface [nucleotide binding]; other site
339671005872	CTC domain interface [polypeptide binding]; other site
339671005873	L16 interface [polypeptide binding]; other site
339671005874	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
339671005875	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
339671005876	tellurite resistance protein TehB; Provisional; Region: PRK12335
339671005877	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
339671005878	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671005879	S-adenosylmethionine binding site [chemical binding]; other site
339671005880	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
339671005881	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671005882	Walker A/P-loop; other site
339671005883	ATP binding site [chemical binding]; other site
339671005884	Q-loop/lid; other site
339671005885	ABC transporter signature motif; other site
339671005886	Walker B; other site
339671005887	D-loop; other site
339671005888	H-loop/switch region; other site
339671005889	TOBE domain; Region: TOBE_2; pfam08402
339671005890	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
339671005891	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671005892	dimer interface [polypeptide binding]; other site
339671005893	conserved gate region; other site
339671005894	putative PBP binding loops; other site
339671005895	ABC-ATPase subunit interface; other site
339671005896	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671005897	dimer interface [polypeptide binding]; other site
339671005898	conserved gate region; other site
339671005899	putative PBP binding loops; other site
339671005900	ABC-ATPase subunit interface; other site
339671005901	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
339671005902	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
339671005903	Walker A/P-loop; other site
339671005904	ATP binding site [chemical binding]; other site
339671005905	Q-loop/lid; other site
339671005906	ABC transporter signature motif; other site
339671005907	Walker B; other site
339671005908	D-loop; other site
339671005909	H-loop/switch region; other site
339671005910	TOBE domain; Region: TOBE_2; pfam08402
339671005911	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
339671005912	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
339671005913	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
339671005914	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
339671005915	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
339671005916	HAMP domain; Region: HAMP; pfam00672
339671005917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
339671005918	ATP binding site [chemical binding]; other site
339671005919	Mg2+ binding site [ion binding]; other site
339671005920	G-X-G motif; other site
339671005921	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
339671005922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
339671005923	active site
339671005924	phosphorylation site [posttranslational modification]
339671005925	intermolecular recognition site; other site
339671005926	dimerization interface [polypeptide binding]; other site
339671005927	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
339671005928	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
339671005929	Uncharacterized protein family (UPF0181); Region: UPF0181; pfam03701
339671005930	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
339671005931	putative active site [active]
339671005932	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
339671005933	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
339671005934	GIY-YIG motif/motif A; other site
339671005935	active site
339671005936	catalytic site [active]
339671005937	putative DNA binding site [nucleotide binding]; other site
339671005938	metal binding site [ion binding]; metal-binding site
339671005939	UvrB/uvrC motif; Region: UVR; pfam02151
339671005940	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
339671005941	Helix-hairpin-helix motif; Region: HHH; pfam00633
339671005942	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
339671005943	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
339671005944	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
339671005945	Ligand binding site; other site
339671005946	oligomer interface; other site
339671005947	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
339671005948	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
339671005949	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
339671005950	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
339671005951	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
339671005952	Walker A/P-loop; other site
339671005953	ATP binding site [chemical binding]; other site
339671005954	Q-loop/lid; other site
339671005955	ABC transporter signature motif; other site
339671005956	Walker B; other site
339671005957	D-loop; other site
339671005958	H-loop/switch region; other site
339671005959	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
339671005960	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
339671005961	Competence protein; Region: Competence; pfam03772
339671005962	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
339671005963	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
339671005964	poly(A) polymerase; Region: pcnB; TIGR01942
339671005965	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
339671005966	active site
339671005967	NTP binding site [chemical binding]; other site
339671005968	metal binding triad [ion binding]; metal-binding site
339671005969	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
339671005970	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
339671005971	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
339671005972	catalytic center binding site [active]
339671005973	ATP binding site [chemical binding]; other site
339671005974	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
339671005975	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
339671005976	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
339671005977	putative active site [active]
339671005978	electron transport complex protein RsxA; Provisional; Region: PRK05151
339671005979	ferredoxin; Provisional; Region: PRK08764
339671005980	Putative Fe-S cluster; Region: FeS; pfam04060
339671005981	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
339671005982	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
339671005983	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
339671005984	SLBB domain; Region: SLBB; pfam10531
339671005985	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
339671005986	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
339671005987	electron transport complex protein RnfG; Validated; Region: PRK01908
339671005988	electron transport complex RsxE subunit; Provisional; Region: PRK12405
339671005989	endonuclease III; Provisional; Region: PRK10702
339671005990	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
339671005991	minor groove reading motif; other site
339671005992	helix-hairpin-helix signature motif; other site
339671005993	substrate binding pocket [chemical binding]; other site
339671005994	active site
339671005995	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
339671005996	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
339671005997	Na2 binding site [ion binding]; other site
339671005998	putative substrate binding site 1 [chemical binding]; other site
339671005999	Na binding site 1 [ion binding]; other site
339671006000	putative substrate binding site 2 [chemical binding]; other site
339671006001	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
339671006002	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
339671006003	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
339671006004	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671006005	dimer interface [polypeptide binding]; other site
339671006006	conserved gate region; other site
339671006007	ABC-ATPase subunit interface; other site
339671006008	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
339671006009	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671006010	dimer interface [polypeptide binding]; other site
339671006011	conserved gate region; other site
339671006012	putative PBP binding loops; other site
339671006013	ABC-ATPase subunit interface; other site
339671006014	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
339671006015	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
339671006016	Walker A/P-loop; other site
339671006017	ATP binding site [chemical binding]; other site
339671006018	Q-loop/lid; other site
339671006019	ABC transporter signature motif; other site
339671006020	Walker B; other site
339671006021	D-loop; other site
339671006022	H-loop/switch region; other site
339671006023	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
339671006024	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
339671006025	metal binding site [ion binding]; metal-binding site
339671006026	dimer interface [polypeptide binding]; other site
339671006027	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
339671006028	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
339671006029	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
339671006030	Ligand Binding Site [chemical binding]; other site
339671006031	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
339671006032	active site residue [active]
339671006033	selenophosphate synthetase; Provisional; Region: PRK00943
339671006034	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
339671006035	dimerization interface [polypeptide binding]; other site
339671006036	putative ATP binding site [chemical binding]; other site
339671006037	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
339671006038	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
339671006039	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
339671006040	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
339671006041	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
339671006042	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
339671006043	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
339671006044	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
339671006045	active site
339671006046	DNA gyrase subunit A; Validated; Region: PRK05560
339671006047	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
339671006048	CAP-like domain; other site
339671006049	active site
339671006050	primary dimer interface [polypeptide binding]; other site
339671006051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
339671006052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
339671006053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
339671006054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
339671006055	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
339671006056	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
339671006057	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
339671006058	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
339671006059	Walker A/P-loop; other site
339671006060	ATP binding site [chemical binding]; other site
339671006061	Q-loop/lid; other site
339671006062	ABC transporter signature motif; other site
339671006063	Walker B; other site
339671006064	D-loop; other site
339671006065	H-loop/switch region; other site
339671006066	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
339671006067	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
339671006068	Walker A/P-loop; other site
339671006069	ATP binding site [chemical binding]; other site
339671006070	Q-loop/lid; other site
339671006071	ABC transporter signature motif; other site
339671006072	Walker B; other site
339671006073	D-loop; other site
339671006074	H-loop/switch region; other site
339671006075	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
339671006076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671006077	dimer interface [polypeptide binding]; other site
339671006078	conserved gate region; other site
339671006079	putative PBP binding loops; other site
339671006080	ABC-ATPase subunit interface; other site
339671006081	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
339671006082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671006083	dimer interface [polypeptide binding]; other site
339671006084	conserved gate region; other site
339671006085	putative PBP binding loops; other site
339671006086	ABC-ATPase subunit interface; other site
339671006087	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
339671006088	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
339671006089	peptide binding site [polypeptide binding]; other site
339671006090	YcjX-like family, DUF463; Region: DUF463; pfam04317
339671006091	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
339671006092	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
339671006093	Mg++ binding site [ion binding]; other site
339671006094	putative catalytic motif [active]
339671006095	substrate binding site [chemical binding]; other site
339671006096	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
339671006097	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
339671006098	inhibitor-cofactor binding pocket; inhibition site
339671006099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671006100	catalytic residue [active]
339671006101	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
339671006102	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
339671006103	active site
339671006104	Int/Topo IB signature motif; other site
339671006105	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
339671006106	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
339671006107	putative acyl-acceptor binding pocket; other site
339671006108	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
339671006109	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
339671006110	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
339671006111	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
339671006112	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
339671006113	putative active site [active]
339671006114	oxyanion strand; other site
339671006115	catalytic triad [active]
339671006116	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
339671006117	MOSC domain; Region: MOSC; pfam03473
339671006118	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
339671006119	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
339671006120	catalytic residues [active]
339671006121	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
339671006122	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
339671006123	substrate binding site [chemical binding]; other site
339671006124	glutamase interaction surface [polypeptide binding]; other site
339671006125	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
339671006126	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
339671006127	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
339671006128	metal binding site [ion binding]; metal-binding site
339671006129	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
339671006130	active site
339671006131	uracil-xanthine permease; Region: ncs2; TIGR00801
339671006132	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
339671006133	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
339671006134	putative active site [active]
339671006135	putative dimer interface [polypeptide binding]; other site
339671006136	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
339671006137	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
339671006138	active site
339671006139	HIGH motif; other site
339671006140	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
339671006141	KMSKS motif; other site
339671006142	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
339671006143	tRNA binding surface [nucleotide binding]; other site
339671006144	anticodon binding site; other site
339671006145	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
339671006146	substrate binding site [chemical binding]; other site
339671006147	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
339671006148	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
339671006149	generic binding surface II; other site
339671006150	generic binding surface I; other site
339671006151	Predicted membrane protein [Function unknown]; Region: COG2860
339671006152	UPF0126 domain; Region: UPF0126; pfam03458
339671006153	UPF0126 domain; Region: UPF0126; pfam03458
339671006154	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
339671006155	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
339671006156	putative active site [active]
339671006157	putative metal binding site [ion binding]; other site
339671006158	poxB regulator PoxA; Provisional; Region: PRK09350
339671006159	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
339671006160	motif 1; other site
339671006161	dimer interface [polypeptide binding]; other site
339671006162	active site
339671006163	motif 2; other site
339671006164	motif 3; other site
339671006165	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
339671006166	hypothetical protein; Provisional; Region: PRK10695
339671006167	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
339671006168	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
339671006169	metal binding site [ion binding]; metal-binding site
339671006170	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
339671006171	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
339671006172	putative ATP binding site [chemical binding]; other site
339671006173	putative substrate interface [chemical binding]; other site
339671006174	murein transglycosylase A; Provisional; Region: mltA; PRK11162
339671006175	MltA specific insert domain; Region: MltA; smart00925
339671006176	3D domain; Region: 3D; pfam06725
339671006177	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
339671006178	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
339671006179	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
339671006180	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
339671006181	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
339671006182	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
339671006183	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
339671006184	ligand binding site [chemical binding]; other site
339671006185	translocation protein TolB; Provisional; Region: tolB; PRK01742
339671006186	TolB amino-terminal domain; Region: TolB_N; pfam04052
339671006187	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
339671006188	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
339671006189	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
339671006190	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
339671006191	colicin uptake protein TolR; Provisional; Region: PRK11024
339671006192	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
339671006193	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
339671006194	active site
339671006195	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
339671006196	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
339671006197	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
339671006198	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
339671006199	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
339671006200	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671006201	Walker A motif; other site
339671006202	ATP binding site [chemical binding]; other site
339671006203	Walker B motif; other site
339671006204	arginine finger; other site
339671006205	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
339671006206	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
339671006207	RuvA N terminal domain; Region: RuvA_N; pfam01330
339671006208	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
339671006209	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
339671006210	active site
339671006211	putative DNA-binding cleft [nucleotide binding]; other site
339671006212	dimer interface [polypeptide binding]; other site
339671006213	hypothetical protein; Validated; Region: PRK00110
339671006214	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
339671006215	nudix motif; other site
339671006216	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
339671006217	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
339671006218	dimer interface [polypeptide binding]; other site
339671006219	anticodon binding site; other site
339671006220	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
339671006221	homodimer interface [polypeptide binding]; other site
339671006222	motif 1; other site
339671006223	active site
339671006224	motif 2; other site
339671006225	GAD domain; Region: GAD; pfam02938
339671006226	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
339671006227	active site
339671006228	motif 3; other site
339671006229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
339671006230	S-adenosylmethionine binding site [chemical binding]; other site
339671006231	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
339671006232	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
339671006233	substrate binding pocket [chemical binding]; other site
339671006234	membrane-bound complex binding site; other site
339671006235	hinge residues; other site
339671006236	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
339671006237	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
339671006238	dimer interface [polypeptide binding]; other site
339671006239	active site
339671006240	metal binding site [ion binding]; metal-binding site
339671006241	glutathione binding site [chemical binding]; other site
339671006242	ribonuclease T; Provisional; Region: PRK05168
339671006243	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
339671006244	active site
339671006245	catalytic site [active]
339671006246	substrate binding site [chemical binding]; other site
339671006247	Predicted permease [General function prediction only]; Region: COG2056
339671006248	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
339671006249	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
339671006250	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
339671006251	16S/18S rRNA binding site [nucleotide binding]; other site
339671006252	S13e-L30e interaction site [polypeptide binding]; other site
339671006253	25S rRNA binding site [nucleotide binding]; other site
339671006254	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
339671006255	L-aspartate oxidase; Provisional; Region: PRK06175
339671006256	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
339671006257	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
339671006258	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
339671006259	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
339671006260	D-subunit interface [polypeptide binding]; other site
339671006261	Iron-sulfur protein interface; other site
339671006262	proximal quinone binding site [chemical binding]; other site
339671006263	distal quinone binding site [chemical binding]; other site
339671006264	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
339671006265	Iron-sulfur protein interface; other site
339671006266	proximal quinone binding site [chemical binding]; other site
339671006267	C-subunit interface; other site
339671006268	distal quinone binding site; other site
339671006269	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
339671006270	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
339671006271	NAD binding site [chemical binding]; other site
339671006272	homodimer interface [polypeptide binding]; other site
339671006273	active site
339671006274	substrate binding site [chemical binding]; other site
339671006275	muropeptide transporter; Reviewed; Region: ampG; PRK11902
339671006276	AmpG-like permease; Region: 2A0125; TIGR00901
339671006277	adenylate kinase; Reviewed; Region: adk; PRK00279
339671006278	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
339671006279	AMP-binding site [chemical binding]; other site
339671006280	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
339671006281	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
339671006282	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
339671006283	putative ligand binding residues [chemical binding]; other site
339671006284	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
339671006285	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
339671006286	Walker A/P-loop; other site
339671006287	ATP binding site [chemical binding]; other site
339671006288	Q-loop/lid; other site
339671006289	ABC transporter signature motif; other site
339671006290	Walker B; other site
339671006291	D-loop; other site
339671006292	H-loop/switch region; other site
339671006293	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
339671006294	ABC-ATPase subunit  interface; other site
339671006295	dimer interface [polypeptide binding]; other site
339671006296	putative PBP binding regions; other site
339671006297	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
339671006298	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
339671006299	ABC-ATPase subunit  interface; other site
339671006300	dimer interface [polypeptide binding]; other site
339671006301	putative PBP binding regions; other site
339671006302	putative peptidase; Provisional; Region: PRK11649
339671006303	Peptidase family M23; Region: Peptidase_M23; pfam01551
339671006304	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
339671006305	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
339671006306	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
339671006307	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
339671006308	ABC-ATPase subunit  interface; other site
339671006309	dimer interface [polypeptide binding]; other site
339671006310	putative PBP binding regions; other site
339671006311	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
339671006312	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
339671006313	active site
339671006314	HIGH motif; other site
339671006315	dimer interface [polypeptide binding]; other site
339671006316	KMSKS motif; other site
339671006317	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
339671006318	RNA binding surface [nucleotide binding]; other site
339671006319	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
339671006320	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
339671006321	putative substrate binding site [chemical binding]; other site
339671006322	putative ATP binding site [chemical binding]; other site
339671006323	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
339671006324	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
339671006325	substrate binding [chemical binding]; other site
339671006326	active site
339671006327	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
339671006328	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
339671006329	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
339671006330	GDP-binding site [chemical binding]; other site
339671006331	ACT binding site; other site
339671006332	IMP binding site; other site
339671006333	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
339671006334	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
339671006335	active site
339671006336	HIGH motif; other site
339671006337	KMSKS motif; other site
339671006338	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
339671006339	tRNA binding surface [nucleotide binding]; other site
339671006340	anticodon binding site; other site
339671006341	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
339671006342	dimer interface [polypeptide binding]; other site
339671006343	putative tRNA-binding site [nucleotide binding]; other site
339671006344	antiporter inner membrane protein; Provisional; Region: PRK11670
339671006345	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
339671006346	Walker A motif; other site
339671006347	Putative zinc-finger; Region: zf-HC2; pfam13490
339671006348	RNA polymerase sigma factor; Provisional; Region: PRK12530
339671006349	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
339671006350	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
339671006351	DNA binding residues [nucleotide binding]
339671006352	TMAO/DMSO reductase; Reviewed; Region: PRK05363
339671006353	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
339671006354	Moco binding site; other site
339671006355	metal coordination site [ion binding]; other site
339671006356	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
339671006357	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
339671006358	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
339671006359	homodimer interface [polypeptide binding]; other site
339671006360	oligonucleotide binding site [chemical binding]; other site
339671006361	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
339671006362	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
339671006363	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
339671006364	RNA binding surface [nucleotide binding]; other site
339671006365	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
339671006366	active site
339671006367	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
339671006368	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
339671006369	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
339671006370	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
339671006371	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
339671006372	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
339671006373	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
339671006374	Protein of unknown function (DUF560); Region: DUF560; pfam04575
339671006375	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
339671006376	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
339671006377	catalytic residues [active]
339671006378	cystathionine gamma-synthase; Reviewed; Region: PRK08247
339671006379	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
339671006380	homodimer interface [polypeptide binding]; other site
339671006381	substrate-cofactor binding pocket; other site
339671006382	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671006383	catalytic residue [active]
339671006384	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
339671006385	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
339671006386	active site
339671006387	tetramer interface [polypeptide binding]; other site
339671006388	GntP family permease; Region: GntP_permease; pfam02447
339671006389	fructuronate transporter; Provisional; Region: PRK10034; cl15264
339671006390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
339671006391	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
339671006392	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
339671006393	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
339671006394	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
339671006395	active site
339671006396	tetramer interface [polypeptide binding]; other site
339671006397	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
339671006398	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
339671006399	active site
339671006400	catalytic tetrad [active]
339671006401	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
339671006402	Strictosidine synthase; Region: Str_synth; pfam03088
339671006403	galactarate dehydratase; Region: galactar-dH20; TIGR03248
339671006404	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
339671006405	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
339671006406	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
339671006407	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
339671006408	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
339671006409	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
339671006410	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
339671006411	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
339671006412	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
339671006413	recombination associated protein; Reviewed; Region: rdgC; PRK00321
339671006414	DNA replication initiation factor; Validated; Region: PRK06893
339671006415	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
339671006416	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
339671006417	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
339671006418	putative active site [active]
339671006419	putative PHP Thumb interface [polypeptide binding]; other site
339671006420	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
339671006421	generic binding surface II; other site
339671006422	generic binding surface I; other site
339671006423	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
339671006424	Domain of unknown function DUF21; Region: DUF21; pfam01595
339671006425	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
339671006426	Transporter associated domain; Region: CorC_HlyC; smart01091
339671006427	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
339671006428	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
339671006429	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
339671006430	active site
339671006431	DNA polymerase III subunit delta'; Validated; Region: PRK06871
339671006432	DNA polymerase III subunit delta'; Validated; Region: PRK08485
339671006433	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
339671006434	thymidylate kinase; Validated; Region: tmk; PRK00698
339671006435	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
339671006436	TMP-binding site; other site
339671006437	ATP-binding site [chemical binding]; other site
339671006438	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
339671006439	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
339671006440	dimerization interface [polypeptide binding]; other site
339671006441	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
339671006442	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
339671006443	ligand binding site [chemical binding]; other site
339671006444	NAD binding site [chemical binding]; other site
339671006445	tetramer interface [polypeptide binding]; other site
339671006446	catalytic site [active]
339671006447	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
339671006448	L-serine binding site [chemical binding]; other site
339671006449	ACT domain interface; other site
339671006450	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
339671006451	tetramer (dimer of dimers) interface [polypeptide binding]; other site
339671006452	active site
339671006453	dimer interface [polypeptide binding]; other site
339671006454	HemN family oxidoreductase; Provisional; Region: PRK05660
339671006455	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671006456	FeS/SAM binding site; other site
339671006457	HemN C-terminal domain; Region: HemN_C; pfam06969
339671006458	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
339671006459	active site
339671006460	dimerization interface [polypeptide binding]; other site
339671006461	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
339671006462	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
339671006463	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
339671006464	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
339671006465	lipoprotein signal peptidase; Provisional; Region: PRK14787
339671006466	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
339671006467	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
339671006468	active site
339671006469	HIGH motif; other site
339671006470	nucleotide binding site [chemical binding]; other site
339671006471	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
339671006472	active site
339671006473	KMSKS motif; other site
339671006474	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
339671006475	tRNA binding surface [nucleotide binding]; other site
339671006476	anticodon binding site; other site
339671006477	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
339671006478	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
339671006479	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
339671006480	active site
339671006481	Riboflavin kinase; Region: Flavokinase; smart00904
339671006482	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
339671006483	dimer interface [polypeptide binding]; other site
339671006484	FMN binding site [chemical binding]; other site
339671006485	NADPH bind site [chemical binding]; other site
339671006486	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
339671006487	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
339671006488	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
339671006489	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
339671006490	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
339671006491	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
339671006492	dimer interface [polypeptide binding]; other site
339671006493	ssDNA binding site [nucleotide binding]; other site
339671006494	tetramer (dimer of dimers) interface [polypeptide binding]; other site
339671006495	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
339671006496	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
339671006497	homooctamer interface [polypeptide binding]; other site
339671006498	active site
339671006499	fatty acid metabolism regulator; Provisional; Region: PRK04984
339671006500	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
339671006501	DNA-binding site [nucleotide binding]; DNA binding site
339671006502	FadR C-terminal domain; Region: FadR_C; pfam07840
339671006503	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
339671006504	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
339671006505	transmembrane helices; other site
339671006506	disulfide bond formation protein B; Provisional; Region: PRK01749
339671006507	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
339671006508	Domain of unknown function DUF20; Region: UPF0118; pfam01594
339671006509	Cytochrome b562; Region: Cytochrom_B562; pfam07361
339671006510	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
339671006511	Nitrogen regulatory protein P-II; Region: P-II; smart00938
339671006512	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
339671006513	MPT binding site; other site
339671006514	trimer interface [polypeptide binding]; other site
339671006515	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
339671006516	RNA/DNA hybrid binding site [nucleotide binding]; other site
339671006517	active site
339671006518	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
339671006519	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
339671006520	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
339671006521	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
339671006522	active site
339671006523	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
339671006524	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
339671006525	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
339671006526	TM-ABC transporter signature motif; other site
339671006527	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
339671006528	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
339671006529	Walker A/P-loop; other site
339671006530	ATP binding site [chemical binding]; other site
339671006531	Q-loop/lid; other site
339671006532	ABC transporter signature motif; other site
339671006533	Walker B; other site
339671006534	D-loop; other site
339671006535	H-loop/switch region; other site
339671006536	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
339671006537	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
339671006538	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
339671006539	ligand binding site [chemical binding]; other site
339671006540	calcium binding site [ion binding]; other site
339671006541	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
339671006542	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
339671006543	dimer interface [polypeptide binding]; other site
339671006544	active site
339671006545	galactokinase; Provisional; Region: PRK05101
339671006546	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
339671006547	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
339671006548	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
339671006549	active site
339671006550	catalytic residues [active]
339671006551	xanthine permease; Region: pbuX; TIGR03173
339671006552	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
339671006553	putative DNA-binding cleft [nucleotide binding]; other site
339671006554	putative DNA clevage site; other site
339671006555	molecular lever; other site
339671006556	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
339671006557	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
339671006558	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
339671006559	DNA binding site [nucleotide binding]
339671006560	active site
339671006561	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
339671006562	2-isopropylmalate synthase; Validated; Region: PRK00915
339671006563	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
339671006564	active site
339671006565	catalytic residues [active]
339671006566	metal binding site [ion binding]; metal-binding site
339671006567	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
339671006568	tartrate dehydrogenase; Region: TTC; TIGR02089
339671006569	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
339671006570	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
339671006571	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
339671006572	substrate binding site [chemical binding]; other site
339671006573	ligand binding site [chemical binding]; other site
339671006574	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
339671006575	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
339671006576	substrate binding site [chemical binding]; other site
339671006577	rod shape-determining protein MreD; Region: MreD; cl01087
339671006578	rod shape-determining protein MreC; Region: mreC; TIGR00219
339671006579	rod shape-determining protein MreC; Region: MreC; pfam04085
339671006580	rod shape-determining protein MreB; Provisional; Region: PRK13927
339671006581	MreB and similar proteins; Region: MreB_like; cd10225
339671006582	nucleotide binding site [chemical binding]; other site
339671006583	Mg binding site [ion binding]; other site
339671006584	putative protofilament interaction site [polypeptide binding]; other site
339671006585	RodZ interaction site [polypeptide binding]; other site
339671006586	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
339671006587	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
339671006588	molybdopterin cofactor binding site [chemical binding]; other site
339671006589	substrate binding site [chemical binding]; other site
339671006590	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
339671006591	molybdopterin cofactor binding site; other site
339671006592	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
339671006593	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
339671006594	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
339671006595	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
339671006596	molybdopterin cofactor binding site [chemical binding]; other site
339671006597	substrate binding site [chemical binding]; other site
339671006598	The MopB_CT_DMSOR-like CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-like; cd02777
339671006599	molybdopterin cofactor binding site; other site
339671006600	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
339671006601	rRNA binding site [nucleotide binding]; other site
339671006602	predicted 30S ribosome binding site; other site
339671006603	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
339671006604	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
339671006605	putative active site [active]
339671006606	catalytic triad [active]
339671006607	putative dimer interface [polypeptide binding]; other site
339671006608	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
339671006609	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
339671006610	Transporter associated domain; Region: CorC_HlyC; smart01091
339671006611	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
339671006612	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
339671006613	PhnA protein; Region: PhnA; pfam03831
339671006614	DctM-like transporters; Region: DctM; pfam06808
339671006615	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
339671006616	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
339671006617	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
339671006618	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
339671006619	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
339671006620	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
339671006621	Prephenate dehydratase; Region: PDT; pfam00800
339671006622	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
339671006623	putative L-Phe binding site [chemical binding]; other site
339671006624	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
339671006625	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
339671006626	active site
339671006627	metal binding site [ion binding]; metal-binding site
339671006628	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
339671006629	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
339671006630	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
339671006631	cell division protein FtsZ; Validated; Region: PRK09330
339671006632	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
339671006633	nucleotide binding site [chemical binding]; other site
339671006634	SulA interaction site; other site
339671006635	cell division protein FtsA; Region: ftsA; TIGR01174
339671006636	Cell division protein FtsA; Region: FtsA; smart00842
339671006637	Cell division protein FtsA; Region: FtsA; pfam14450
339671006638	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
339671006639	Cell division protein FtsQ; Region: FtsQ; pfam03799
339671006640	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
339671006641	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
339671006642	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
339671006643	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
339671006644	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
339671006645	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
339671006646	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
339671006647	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
339671006648	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
339671006649	active site
339671006650	homodimer interface [polypeptide binding]; other site
339671006651	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
339671006652	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
339671006653	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
339671006654	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
339671006655	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
339671006656	Mg++ binding site [ion binding]; other site
339671006657	putative catalytic motif [active]
339671006658	putative substrate binding site [chemical binding]; other site
339671006659	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
339671006660	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
339671006661	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
339671006662	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
339671006663	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
339671006664	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
339671006665	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
339671006666	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
339671006667	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
339671006668	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
339671006669	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
339671006670	Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116
339671006671	MraW methylase family; Region: Methyltransf_5; pfam01795
339671006672	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
339671006673	cell division protein MraZ; Reviewed; Region: PRK00326
339671006674	MraZ protein; Region: MraZ; pfam02381
339671006675	MraZ protein; Region: MraZ; pfam02381
339671006676	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
339671006677	Carbon starvation protein CstA; Region: CstA; pfam02554
339671006678	Carbon starvation protein CstA; Region: CstA; pfam02554
339671006679	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
339671006680	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
339671006681	Helicase; Region: Helicase_RecD; pfam05127
339671006682	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
339671006683	Coenzyme A binding pocket [chemical binding]; other site
339671006684	metal-binding heat shock protein; Provisional; Region: PRK00016
339671006685	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
339671006686	PhoH-like protein; Region: PhoH; pfam02562
339671006687	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
339671006688	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
339671006689	ATP-grasp domain; Region: ATP-grasp_4; cl17255
339671006690	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
339671006691	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
339671006692	substrate binding pocket [chemical binding]; other site
339671006693	membrane-bound complex binding site; other site
339671006694	hinge residues; other site
339671006695	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
339671006696	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
339671006697	Walker A/P-loop; other site
339671006698	ATP binding site [chemical binding]; other site
339671006699	Q-loop/lid; other site
339671006700	ABC transporter signature motif; other site
339671006701	Walker B; other site
339671006702	D-loop; other site
339671006703	H-loop/switch region; other site
339671006704	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
339671006705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671006706	dimer interface [polypeptide binding]; other site
339671006707	conserved gate region; other site
339671006708	putative PBP binding loops; other site
339671006709	ABC-ATPase subunit interface; other site
339671006710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
339671006711	dimer interface [polypeptide binding]; other site
339671006712	conserved gate region; other site
339671006713	putative PBP binding loops; other site
339671006714	ABC-ATPase subunit interface; other site
339671006715	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
339671006716	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
339671006717	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671006718	FeS/SAM binding site; other site
339671006719	TRAM domain; Region: TRAM; pfam01938
339671006720	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
339671006721	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
339671006722	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
339671006723	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
339671006724	inhibitor site; inhibition site
339671006725	active site
339671006726	dimer interface [polypeptide binding]; other site
339671006727	catalytic residue [active]
339671006728	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
339671006729	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
339671006730	putative active site [active]
339671006731	metal binding site [ion binding]; metal-binding site
339671006732	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
339671006733	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
339671006734	DctM-like transporters; Region: DctM; pfam06808
339671006735	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
339671006736	Na binding site [ion binding]; other site
339671006737	BNR repeat-like domain; Region: BNR_2; pfam13088
339671006738	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
339671006739	catalytic site [active]
339671006740	Asp-box motif; other site
339671006741	Domain of unknown function (DUF386); Region: DUF386; cl01047
339671006742	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
339671006743	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
339671006744	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
339671006745	trimer interface [polypeptide binding]; other site
339671006746	active site
339671006747	UDP-GlcNAc binding site [chemical binding]; other site
339671006748	lipid binding site [chemical binding]; lipid-binding site
339671006749	periplasmic chaperone; Provisional; Region: PRK10780
339671006750	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
339671006751	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
339671006752	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
339671006753	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
339671006754	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
339671006755	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
339671006756	Surface antigen; Region: Bac_surface_Ag; pfam01103
339671006757	zinc metallopeptidase RseP; Provisional; Region: PRK10779
339671006758	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
339671006759	active site
339671006760	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
339671006761	protein binding site [polypeptide binding]; other site
339671006762	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
339671006763	protein binding site [polypeptide binding]; other site
339671006764	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
339671006765	putative substrate binding region [chemical binding]; other site
339671006766	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
339671006767	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
339671006768	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
339671006769	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
339671006770	catalytic residue [active]
339671006771	putative FPP diphosphate  binding site; other site
339671006772	putative FPP binding hydrophobic cleft; other site
339671006773	dimer interface [polypeptide binding]; other site
339671006774	putative IPP diphosphate binding site; other site
339671006775	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
339671006776	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
339671006777	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
339671006778	hypothetical protein; Provisional; Region: PRK10963
339671006779	L-lactate permease; Region: Lactate_perm; cl00701
339671006780	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
339671006781	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
339671006782	Cysteine-rich domain; Region: CCG; pfam02754
339671006783	Cysteine-rich domain; Region: CCG; pfam02754
339671006784	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
339671006785	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
339671006786	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
339671006787	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
339671006788	Uncharacterized conserved protein [Function unknown]; Region: COG1556
339671006789	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
339671006790	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
339671006791	active site
339671006792	Int/Topo IB signature motif; other site
339671006793	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
339671006794	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671006795	active site
339671006796	motif I; other site
339671006797	motif II; other site
339671006798	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
339671006799	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
339671006800	trmE is a tRNA modification GTPase; Region: trmE; cd04164
339671006801	G1 box; other site
339671006802	GTP/Mg2+ binding site [chemical binding]; other site
339671006803	Switch I region; other site
339671006804	G2 box; other site
339671006805	Switch II region; other site
339671006806	G3 box; other site
339671006807	G4 box; other site
339671006808	G5 box; other site
339671006809	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
339671006810	hypothetical protein; Validated; Region: PRK05090
339671006811	YGGT family; Region: YGGT; pfam02325
339671006812	YGGT family; Region: YGGT; pfam02325
339671006813	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
339671006814	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
339671006815	Cl binding site [ion binding]; other site
339671006816	oligomer interface [polypeptide binding]; other site
339671006817	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
339671006818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
339671006819	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
339671006820	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
339671006821	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
339671006822	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
339671006823	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
339671006824	putative NADH binding site [chemical binding]; other site
339671006825	putative active site [active]
339671006826	nudix motif; other site
339671006827	putative metal binding site [ion binding]; other site
339671006828	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
339671006829	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
339671006830	substrate binding site [chemical binding]; other site
339671006831	active site
339671006832	Protein of unknown function (DUF416); Region: DUF416; cl01166
339671006833	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
339671006834	IHF - DNA interface [nucleotide binding]; other site
339671006835	IHF dimer interface [polypeptide binding]; other site
339671006836	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
339671006837	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
339671006838	active site
339671006839	ATP binding site [chemical binding]; other site
339671006840	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
339671006841	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
339671006842	putative active site [active]
339671006843	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
339671006844	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
339671006845	active site
339671006846	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
339671006847	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
339671006848	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
339671006849	Ligand Binding Site [chemical binding]; other site
339671006850	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
339671006851	DctM-like transporters; Region: DctM; pfam06808
339671006852	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
339671006853	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
339671006854	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
339671006855	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
339671006856	ATP-dependent helicase HepA; Validated; Region: PRK04914
339671006857	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
339671006858	ATP binding site [chemical binding]; other site
339671006859	putative Mg++ binding site [ion binding]; other site
339671006860	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
339671006861	nucleotide binding region [chemical binding]; other site
339671006862	ATP-binding site [chemical binding]; other site
339671006863	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
339671006864	Predicted membrane protein [Function unknown]; Region: COG1971
339671006865	Domain of unknown function DUF; Region: DUF204; pfam02659
339671006866	Domain of unknown function DUF; Region: DUF204; pfam02659
339671006867	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
339671006868	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671006869	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
339671006870	active site
339671006871	motif I; other site
339671006872	motif II; other site
339671006873	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671006874	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
339671006875	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
339671006876	acyl carrier protein; Provisional; Region: acpP; PRK00982
339671006877	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
339671006878	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
339671006879	NAD(P) binding site [chemical binding]; other site
339671006880	homotetramer interface [polypeptide binding]; other site
339671006881	homodimer interface [polypeptide binding]; other site
339671006882	active site
339671006883	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
339671006884	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
339671006885	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
339671006886	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
339671006887	dimer interface [polypeptide binding]; other site
339671006888	active site
339671006889	CoA binding pocket [chemical binding]; other site
339671006890	putative phosphate acyltransferase; Provisional; Region: PRK05331
339671006891	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
339671006892	hypothetical protein; Provisional; Region: PRK11193
339671006893	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
339671006894	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
339671006895	domain interface [polypeptide binding]; other site
339671006896	putative active site [active]
339671006897	catalytic site [active]
339671006898	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
339671006899	domain interface [polypeptide binding]; other site
339671006900	putative active site [active]
339671006901	catalytic site [active]
339671006902	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
339671006903	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
339671006904	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
339671006905	Protein of unknown function (DUF554); Region: DUF554; pfam04474
339671006906	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
339671006907	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
339671006908	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
339671006909	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
339671006910	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
339671006911	UGMP family protein; Validated; Region: PRK09604
339671006912	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
339671006913	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
339671006914	Clp amino terminal domain; Region: Clp_N; pfam02861
339671006915	Clp amino terminal domain; Region: Clp_N; pfam02861
339671006916	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671006917	Walker A motif; other site
339671006918	ATP binding site [chemical binding]; other site
339671006919	Walker B motif; other site
339671006920	arginine finger; other site
339671006921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
339671006922	Walker A motif; other site
339671006923	ATP binding site [chemical binding]; other site
339671006924	Walker B motif; other site
339671006925	arginine finger; other site
339671006926	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
339671006927	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
339671006928	intersubunit interface [polypeptide binding]; other site
339671006929	active site
339671006930	catalytic residue [active]
339671006931	Predicted metalloprotease [General function prediction only]; Region: COG2321
339671006932	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
339671006933	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
339671006934	Ligand Binding Site [chemical binding]; other site
339671006935	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
339671006936	active site
339671006937	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
339671006938	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671006939	FeS/SAM binding site; other site
339671006940	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
339671006941	active site
339671006942	8-oxo-dGMP binding site [chemical binding]; other site
339671006943	nudix motif; other site
339671006944	metal binding site [ion binding]; metal-binding site
339671006945	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
339671006946	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
339671006947	SEC-C motif; Region: SEC-C; pfam02810
339671006948	Protein of unknown function (DUF2547); Region: DUF2547; pfam10818
339671006949	Protein of unknown function (DUF721); Region: DUF721; cl02324
339671006950	glutathione reductase; Validated; Region: PRK06116
339671006951	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
339671006952	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
339671006953	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
339671006954	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
339671006955	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
339671006956	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
339671006957	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
339671006958	dimer interface [polypeptide binding]; other site
339671006959	motif 1; other site
339671006960	active site
339671006961	motif 2; other site
339671006962	motif 3; other site
339671006963	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
339671006964	anticodon binding site; other site
339671006965	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
339671006966	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
339671006967	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
339671006968	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
339671006969	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
339671006970	non-specific DNA binding site [nucleotide binding]; other site
339671006971	salt bridge; other site
339671006972	sequence-specific DNA binding site [nucleotide binding]; other site
339671006973	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
339671006974	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
339671006975	binding surface
339671006976	TPR motif; other site
339671006977	TPR repeat; Region: TPR_11; pfam13414
339671006978	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
339671006979	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671006980	FeS/SAM binding site; other site
339671006981	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
339671006982	homotrimer interaction site [polypeptide binding]; other site
339671006983	zinc binding site [ion binding]; other site
339671006984	CDP-binding sites; other site
339671006985	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
339671006986	substrate binding site; other site
339671006987	dimer interface; other site
339671006988	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
339671006989	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
339671006990	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
339671006991	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
339671006992	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
339671006993	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
339671006994	4Fe-4S binding domain; Region: Fer4_5; pfam12801
339671006995	4Fe-4S binding domain; Region: Fer4_6; pfam12837
339671006996	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
339671006997	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
339671006998	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
339671006999	[4Fe-4S] binding site [ion binding]; other site
339671007000	molybdopterin cofactor binding site; other site
339671007001	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
339671007002	molybdopterin cofactor binding site; other site
339671007003	NapD protein; Region: NapD; pfam03927
339671007004	ferredoxin-type protein NapF; Region: napF; TIGR00402
339671007005	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
339671007006	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
339671007007	Patatin-like phospholipase; Region: Patatin; pfam01734
339671007008	active site
339671007009	nucleophile elbow; other site
339671007010	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
339671007011	Domain of unknown function DUF20; Region: UPF0118; pfam01594
339671007012	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
339671007013	Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; pfam10008
339671007014	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
339671007015	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
339671007016	nudix motif; other site
339671007017	Protein of unknown function (DUF560); Region: DUF560; pfam04575
339671007018	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
339671007019	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
339671007020	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
339671007021	non-specific DNA binding site [nucleotide binding]; other site
339671007022	salt bridge; other site
339671007023	sequence-specific DNA binding site [nucleotide binding]; other site
339671007024	enolase; Provisional; Region: eno; PRK00077
339671007025	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
339671007026	dimer interface [polypeptide binding]; other site
339671007027	metal binding site [ion binding]; metal-binding site
339671007028	substrate binding pocket [chemical binding]; other site
339671007029	CTP synthetase; Validated; Region: pyrG; PRK05380
339671007030	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
339671007031	Catalytic site [active]
339671007032	active site
339671007033	UTP binding site [chemical binding]; other site
339671007034	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
339671007035	active site
339671007036	putative oxyanion hole; other site
339671007037	catalytic triad [active]
339671007038	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
339671007039	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
339671007040	Permutation of conserved domain; other site
339671007041	active site
339671007042	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
339671007043	Haem-binding domain; Region: Haem_bd; pfam14376
339671007044	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
339671007045	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
339671007046	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
339671007047	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
339671007048	DNA binding residues [nucleotide binding]
339671007049	putative dimer interface [polypeptide binding]; other site
339671007050	benzoate transport; Region: 2A0115; TIGR00895
339671007051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671007052	putative substrate translocation pore; other site
339671007053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
339671007054	hypothetical protein; Provisional; Region: PRK11212
339671007055	putative transporter; Provisional; Region: PRK11660
339671007056	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
339671007057	Sulfate transporter family; Region: Sulfate_transp; pfam00916
339671007058	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
339671007059	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
339671007060	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
339671007061	ATP binding site [chemical binding]; other site
339671007062	Mg++ binding site [ion binding]; other site
339671007063	motif III; other site
339671007064	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
339671007065	nucleotide binding region [chemical binding]; other site
339671007066	ATP-binding site [chemical binding]; other site
339671007067	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
339671007068	putative RNA binding site [nucleotide binding]; other site
339671007069	lipoprotein NlpI; Provisional; Region: PRK11189
339671007070	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
339671007071	binding surface
339671007072	TPR motif; other site
339671007073	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
339671007074	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
339671007075	RNase E interface [polypeptide binding]; other site
339671007076	trimer interface [polypeptide binding]; other site
339671007077	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
339671007078	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
339671007079	RNase E interface [polypeptide binding]; other site
339671007080	trimer interface [polypeptide binding]; other site
339671007081	active site
339671007082	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
339671007083	putative nucleic acid binding region [nucleotide binding]; other site
339671007084	G-X-X-G motif; other site
339671007085	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
339671007086	RNA binding site [nucleotide binding]; other site
339671007087	domain interface; other site
339671007088	Domain of unknown function (DUF386); Region: DUF386; pfam04074
339671007089	exoribonuclease R; Provisional; Region: PRK11642
339671007090	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
339671007091	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
339671007092	RNB domain; Region: RNB; pfam00773
339671007093	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
339671007094	RNA binding site [nucleotide binding]; other site
339671007095	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
339671007096	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
339671007097	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
339671007098	thymidine kinase; Provisional; Region: PRK04296
339671007099	Predicted small secreted protein [Function unknown]; Region: COG5510
339671007100	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
339671007101	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
339671007102	nucleotide binding pocket [chemical binding]; other site
339671007103	K-X-D-G motif; other site
339671007104	catalytic site [active]
339671007105	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
339671007106	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
339671007107	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
339671007108	Dimer interface [polypeptide binding]; other site
339671007109	BRCT sequence motif; other site
339671007110	cell division protein ZipA; Provisional; Region: PRK01741
339671007111	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
339671007112	FtsZ protein binding site [polypeptide binding]; other site
339671007113	putative sulfate transport protein CysZ; Validated; Region: PRK04949
339671007114	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
339671007115	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
339671007116	putative active site [active]
339671007117	putative metal binding site [ion binding]; other site
339671007118	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
339671007119	putative acyl-acceptor binding pocket; other site
339671007120	FtsI repressor; Provisional; Region: PRK10883
339671007121	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
339671007122	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
339671007123	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
339671007124	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
339671007125	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
339671007126	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
339671007127	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
339671007128	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
339671007129	catalytic residues [active]
339671007130	Predicted transcriptional regulators [Transcription]; Region: COG1733
339671007131	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
339671007132	dimerization interface [polypeptide binding]; other site
339671007133	putative DNA binding site [nucleotide binding]; other site
339671007134	putative Zn2+ binding site [ion binding]; other site
339671007135	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
339671007136	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
339671007137	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
339671007138	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
339671007139	SnoaL-like domain; Region: SnoaL_4; pfam13577
339671007140	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
339671007141	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
339671007142	catalytic site [active]
339671007143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
339671007144	NADH(P)-binding; Region: NAD_binding_10; pfam13460
339671007145	NAD(P) binding site [chemical binding]; other site
339671007146	active site
339671007147	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
339671007148	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
339671007149	catalytic site [active]
339671007150	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
339671007151	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
339671007152	active site
339671007153	catalytic tetrad [active]
339671007154	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
339671007155	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
339671007156	active site
339671007157	catalytic tetrad [active]
339671007158	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
339671007159	AAA domain; Region: AAA_14; pfam13173
339671007160	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
339671007161	flavodoxin; Provisional; Region: PRK06934
339671007162	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
339671007163	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
339671007164	substrate binding pocket [chemical binding]; other site
339671007165	catalytic triad [active]
339671007166	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
339671007167	active site
339671007168	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
339671007169	catalytic tetrad [active]
339671007170	Transcriptional regulator [Transcription]; Region: LysR; COG0583
339671007171	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
339671007172	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
339671007173	putative effector binding pocket; other site
339671007174	putative dimerization interface [polypeptide binding]; other site
339671007175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
339671007176	Coenzyme A binding pocket [chemical binding]; other site
339671007177	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
339671007178	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
339671007179	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
339671007180	putative NAD(P) binding site [chemical binding]; other site
339671007181	putative substrate binding site [chemical binding]; other site
339671007182	catalytic Zn binding site [ion binding]; other site
339671007183	structural Zn binding site [ion binding]; other site
339671007184	dimer interface [polypeptide binding]; other site
339671007185	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
339671007186	NADH(P)-binding; Region: NAD_binding_10; pfam13460
339671007187	NAD binding site [chemical binding]; other site
339671007188	substrate binding site [chemical binding]; other site
339671007189	putative active site [active]
339671007190	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
339671007191	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
339671007192	Zn2+ binding site [ion binding]; other site
339671007193	Mg2+ binding site [ion binding]; other site
339671007194	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
339671007195	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
339671007196	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
339671007197	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
339671007198	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
339671007199	FeS/SAM binding site; other site
339671007200	elongation factor P; Validated; Region: PRK00529
339671007201	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
339671007202	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
339671007203	RNA binding site [nucleotide binding]; other site
339671007204	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
339671007205	RNA binding site [nucleotide binding]; other site
339671007206	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
339671007207	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
339671007208	dimer interface [polypeptide binding]; other site
339671007209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
339671007210	catalytic residue [active]
339671007211	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
339671007212	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
339671007213	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
339671007214	Bacterial virulence factor haemolysin; Region: SMP_2; pfam10144
339671007215	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
339671007216	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
339671007217	motif II; other site
339671007218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
339671007219	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
339671007220	membrane protein insertase; Provisional; Region: PRK01318
339671007221	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
339671007222	hypothetical protein; Validated; Region: PRK00041
339671007223	ribonuclease P; Reviewed; Region: rnpA; PRK01732
339671007224	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399