-- dump date 20140618_191208 -- class Genbank::CDS -- table cds_note -- id note YP_001343318.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001343319.1 binds the polymerase to DNA and acts as a sliding clamp YP_001343320.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001343321.1 KEGG: msu:MS0296 hypothetical protein YP_001343322.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_001343323.1 TIGRFAM: potassium efflux system protein; PFAM: TrkA-N domain protein; sodium/hydrogen exchanger; KEGG: hso:HS_1497 glutathione-regulated potassium-efflux system protein YP_001343324.1 PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: hin:HI0095 hypothetical protein YP_001343325.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_001343326.1 PFAM: protein of unknown function UPF0270; KEGG: msu:MS1935 hypothetical protein YP_001343327.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_001343328.1 catalyzes the formation of dUMP from dUTP YP_001343329.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_001343330.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001343331.1 required for 70S ribosome assembly YP_001343332.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001343333.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001343334.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001343335.1 PFAM: NlpBDapX family lipoprotein; KEGG: msu:MS0267 uncharacterized lipoprotein YP_001343336.1 PFAM: methyltransferase small; Methyltransferase type 12; KEGG: msu:MS0203 SmtA protein YP_001343337.1 TIGRFAM: anion transporter; PFAM: sodium/sulphate symporter; Citrate transporter; KEGG: pmu:PM1167 hypothetical HI0608 YP_001343338.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001343339.1 PFAM: ABC transporter related; SbmABacA family protein; ABC transporter domain protein; SMART: AAA ATPase; KEGG: msu:MS0290 ABC-type long-chain fatty acid transport system, fused permease and ATPase components YP_001343340.1 TIGRFAM: YidE/YbjL duplication; PFAM: TrkA-C domain protein; YidE/YbjL duplication domain protein; KEGG: pmu:PM1071 hypothetical HI0035 YP_001343341.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_001343342.1 PFAM: helix-turn-helix domain protein; KEGG: pha:PSHAa2249 DNA binding protein YP_001343343.1 KEGG: pfo:Pfl_3252 putative lipoprotein YP_001343344.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001343345.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_001343346.1 PFAM: phage integrase family protein; KEGG: bml:BMA10299_A1532 site-specific recombinase, phage integrase family YP_001343347.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_001343348.1 part of the metNIQ transport system for methionine YP_001343349.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS0433 hypothetical protein YP_001343350.1 TIGRFAM: lipoprotein, YaeC family; PFAM: NLPA lipoprotein; KEGG: msu:MS0432 lipoprotein, attached to the cytoplasmic membrane YP_001343351.1 PFAM: protein of unknown function DUF152; KEGG: msu:MS1822 uncharacterized ACR YP_001343352.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA YP_001343353.1 KEGG: msu:MS1820 TPR-repeat-containing proteins YP_001343354.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001343355.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_001343356.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001343357.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001343358.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001343359.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001343360.1 PFAM: ribosomal protein L1; KEGG: hit:NTHI0642 50S ribosomal protein L1 YP_001343361.1 binds directly to 23S ribosomal RNA YP_001343363.1 Modulates Rho-dependent transcription termination YP_001343364.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001343365.1 TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: msu:MS0345 UDP-glucose pyrophosphorylase YP_001343366.1 PFAM: phosphoglucomutase/phosphomannomutase ; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: msu:MS0346 phosphomannomutase YP_001343367.1 affects carbohydrate metabolism; has regulatory role in many processes YP_001343368.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001343369.1 PFAM: UspA domain protein; KEGG: msu:MS0349 universal stress protein UspA and related nucleotide-binding proteins YP_001343370.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001343371.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; KEGG: neu:NE1343 UDP-glucose/GDP-mannose dehydrogenase family YP_001343372.1 KEGG: ana:all5192 hypothetical protein YP_001343373.1 PFAM: ABC transporter transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: ava:Ava_2435 ABC transporter, transmembrane region YP_001343374.1 PFAM: glycosyl transferase group 1; KEGG: syn:sll1724 LPS glycosyltransferase IcsA YP_001343375.1 PFAM: glycosyl transferase group 1; KEGG: ava:Ava_2433 glycosyl transferase, group 1 YP_001343376.1 KEGG: ana:all5196 hypothetical protein YP_001343377.1 PFAM: porin Gram-negative type; KEGG: hdu:HD1433 outer membrane protein P2 homolog YP_001343378.1 PFAM: aldo/keto reductase; KEGG: ecv:APECO1_1695 2,5-diketo-D-gluconic acid reductase A YP_001343379.1 PFAM: helix-turn-helix- domain containing protein AraC type; ThiJ/PfpI domain protein; KEGG: shn:Shewana3_2327 transcriptional regulator, AraC family YP_001343380.1 KEGG: shn:Shewana3_2326 conserved hypothetical protein YP_001343381.1 PFAM: HhH-GPD family protein; KEGG: lwe:lwe0626 endonuclease III domain protein YP_001343382.1 TIGRFAM: S-formylglutathione hydrolase; PFAM: putative esterase; KEGG: smu:SMU.118c putative esterase YP_001343383.1 TIGRFAM: Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: smu:SMU.119 putative alcohol dehydrogenase class III YP_001343384.1 PFAM: protein of unknown function DUF606; KEGG: msu:MS2114 hypothetical protein YP_001343385.1 KEGG: msu:MS2125 hypothetical protein YP_001343386.1 KEGG: msu:MS2127 hypothetical protein YP_001343387.1 KEGG: msu:MS2128 acetyltransferases (the isoleucine patch superfamily) YP_001343388.1 KEGG: msu:MS2129 hydrolases of the alpha/beta superfamily YP_001343389.1 PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: lca:LSEI_0165 helicase subunit of the Holliday junction resolvase related ATPase YP_001343390.1 PFAM: C4-dicarboxylate transporter/malic acid transport protein; KEGG: msu:MS0026 tellurite resistance protein and related permeases YP_001343391.1 PFAM: regulatory protein TetR; KEGG: msu:MS2211 AcrR protein YP_001343392.1 PFAM: 17 kDa surface antigen; KEGG: msu:MS2210 osmotically inducible lipoprotein B YP_001343393.1 PFAM: 17 kDa surface antigen; KEGG: msu:MS2209 hypothetical protein YP_001343394.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: msu:MS2130 LysR protein YP_001343395.1 TIGRFAM: drug resistance transporter, Bcr/CflA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: bfs:BF2930 putative antibiotic resistance transport membrane protein YP_001343396.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: cvi:CV2939 probable transcriptional regulator YP_001343397.1 PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: msu:MS1612 periplasmic sugar-binding proteins YP_001343398.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS1611 ABC-type sugar (aldose) transport system, ATPase component YP_001343399.1 PFAM: inner-membrane translocator; KEGG: msu:MS1610 ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components YP_001343400.1 PFAM: carbohydrate kinase FGGY; KEGG: msu:MS1609 XylB protein YP_001343401.1 TIGRFAM: PTS system, fructose-specific, IIB subunnit; PTS system, fructose subfamily, IIC subunit; PFAM: phosphotransferase system EIIC; phosphotransferase system PTS fructose-specific IIB subunit; KEGG: msu:MS2178 phosphotransferase system, fructose-specific IIC component YP_001343402.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers YP_001343403.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr YP_001343404.1 KEGG: msu:MS2181 hypothetical protein YP_001343405.1 PFAM: Rhodanese domain protein; KEGG: msu:MS2183 rhodanese-related sulfurtransferases YP_001343406.1 KEGG: hso:HS_0161 hypothetical protein YP_001343407.1 PFAM: Rhomboid family protein; KEGG: pmu:PM1438 Glp homolog YP_001343408.1 PFAM: regulatory protein DeoR; Helix-turn-helix type 11 domain protein; regulatory protein DeoR; KEGG: msu:MS2186 transcriptional regulators of sugar metabolism YP_001343409.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001343410.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001343411.1 PFAM: lipopolysaccharide biosynthesis protein; KEGG: msu:MS1486 uncharacterized protein involved in exopolysaccharide biosynthesis YP_001343412.1 PFAM: polysaccharide export protein; KEGG: msu:MS1487 periplasmic protein involved in polysaccharide export YP_001343413.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; KEGG: msu:MS1488 hypothetical protein YP_001343414.1 PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; KEGG: msu:MS1489 WecE protein YP_001343415.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: msu:MS1490 hypothetical protein YP_001343416.1 undetermined role; similar to CarB protein but much smaller YP_001343417.1 PFAM: sugar transferase; KEGG: msu:MS1492 WcaJ protein YP_001343418.1 PFAM: O-antigen polymerase; KEGG: msu:MS1493 hypothetical protein YP_001343419.1 PFAM: glycosyl transferase group 1; KEGG: msu:MS1494 RfaG protein YP_001343420.1 PFAM: polysaccharide biosynthesis protein; virulence factor MVIN family protein; KEGG: msu:MS1495 RfbX protein YP_001343421.1 PFAM: glycosyl transferase group 1; KEGG: msu:MS1496 RfaG protein YP_001343422.1 PFAM: glycosyl transferase group 1; KEGG: msu:MS1497 RfaG protein YP_001343423.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: msu:MS1498 WecE protein YP_001343424.1 PFAM: transferase hexapeptide repeat containing protein; KEGG: msu:MS1499 WbbJ protein YP_001343425.1 PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: msu:MS1500 MviM protein YP_001343426.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; KEGG: msu:MS1501 WecC protein YP_001343427.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001343428.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_001343429.1 TIGRFAM: sun protein; PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; KEGG: msu:MS2203 tRNA and rRNA cytosine-C5-methylases YP_001343430.1 TIGRFAM: oligopeptide transporters, OPT superfamily; oligopeptide transporter, OPT family; PFAM: Oligopeptide transporter OPT superfamily protein; KEGG: hso:HS_0311 integral membrane protein YP_001343431.1 KEGG: pmu:PM1361 kmt1 YP_001343432.1 PFAM: cyclase family protein; KEGG: hin:HI1016 hypothetical protein YP_001343433.1 PFAM: phospholipase/Carboxylesterase; KEGG: pmu:PM1358 hypothetical T. maritima YP_001343434.1 TIGRFAM: gluconate transporter; PFAM: Gluconate transporter; Citrate transporter; KEGG: msu:MS1977 H+/gluconate symporter and related permeases YP_001343435.1 PFAM: Xylose isomerase domain protein TIM barrel; KEGG: msu:MS1978 Hfi protein YP_001343436.1 PFAM: class II aldolase/adducin family protein; KEGG: msu:MS1979 hypothetical protein YP_001343437.1 PFAM: type III effector Hrp-dependent outers; KEGG: hin:HI1011 hypothetical protein YP_001343438.1 PFAM: 6-phosphogluconate dehydrogenase NAD-binding; KEGG: hin:HI1010 3-hydroxyisobutyrate dehydrogenase,putative YP_001343439.1 PFAM: regulatory protein DeoR; Helix-turn-helix type 11 domain protein; regulatory protein DeoR; KEGG: pmu:PM1367 glycerol-3 phosphate regulon, putative YP_001343440.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_001343441.1 PFAM: regulatory protein DeoR; regulatory protein DeoR; KEGG: hso:HS_0922 transcriptional regulator, DeoR family YP_001343442.1 TIGRFAM: PTS system, glucose subfamily, IIA subunit; PFAM: sugar-specific permease EIIA 1 domain; KEGG: msu:MS1408 NagE protein YP_001343443.1 TIGRFAM: sugar (Glycoside-Pentoside-Hexuronide) transporter; PFAM: major facilitator superfamily MFS_1; KEGG: msu:MS1409 MelB protein YP_001343444.1 PFAM: carbohydrate kinase FGGY; KEGG: msu:MS1411 XylB protein YP_001343445.1 PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: msu:MS1412 FabG protein YP_001343446.1 PFAM: ROK family protein; KEGG: msu:MS1413 NagC protein YP_001343447.1 negatively supercoils closed circular double-stranded DNA YP_001343448.1 PFAM: alpha/beta hydrolase fold; KEGG: lpp:lpp2473 hypothetical protein YP_001343449.1 PFAM: 4-oxalocrotonate tautomerase; KEGG: aba:Acid345_2511 4-oxalocrotonate tautomerase YP_001343450.1 PFAM: NADP oxidoreductase coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: llm:llmg_0880 putative oxidoreductase YP_001343451.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pau:PA14_01500 putative transcriptional regulator YP_001343452.1 TIGRFAM: RNA methyltransferase, TrmH family, group 2; PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: hit:NTHI0927 conserved hypothetical tRNA/rRNA methyltransferase YP_001343453.1 PFAM: protein of unknown function DUF465; KEGG: pmu:PM1568 hypothetical H. pylori YP_001343454.1 PFAM: low molecular weight phosphotyrosine protein phosphatase; KEGG: pmu:PM1569 tyrosine phosphatase, putative YP_001343455.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis YP_001343456.1 catalyzes the formation of fumarate from aspartate YP_001343457.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_001343458.1 PFAM: Endonuclease/exonuclease/phosphatase; KEGG: msu:MS0872 hypothetical protein YP_001343459.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_001343460.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_001343461.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit; KEGG: msu:MS0542 DctP protein YP_001343462.1 PFAM: Tripartite ATP-independent periplasmic transporter DctQ component; KEGG: msu:MS0541 hypothetical protein YP_001343463.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: msu:MS0540 hypothetical protein YP_001343464.1 PFAM: glycoside hydrolase family 31; KEGG: msu:MS0539 alpha-glucosidases, family 31 of glycosyl hydrolases YP_001343465.1 PFAM: regulatory protein GntR HTH; GntR domain protein; KEGG: msu:MS0538 FadR protein YP_001343466.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001343467.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_001343468.1 PFAM: PfkB domain protein; KEGG: msu:MS0545 sugar kinases, ribokinase family YP_001343469.1 PFAM: D-galactarate dehydratase/Altronate hydrolase domain protein; SAF domain protein; KEGG: msu:MS0530 altronate dehydratase YP_001343470.1 catalyzes the formation of D-tagaturonate from D-altronate YP_001343471.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: C4-dicarboxylate anaerobic carrier; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: msu:MS0528 hypothetical protein YP_001343472.1 PFAM: Tripartite ATP-independent periplasmic transporter DctQ component; KEGG: msu:MS0527 hypothetical protein YP_001343473.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit; KEGG: msu:MS0526 DctP protein YP_001343474.1 PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: msu:MS0525 Tdh protein YP_001343475.1 PFAM: GntR domain protein; KEGG: msu:MS0524 GntR protein YP_001343476.1 PFAM: GCN5-related N-acetyltransferase; KEGG: msu:MS2289 sortase and related acyltransferases YP_001343477.1 PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: msu:MS2288 sensory transduction histidine kinases YP_001343478.1 PFAM: Ferritin Dps family protein; KEGG: msu:MS0670 starvation-inducible DNA-binding protein YP_001343479.1 PFAM: conserved hypothetical protein 743; KEGG: hdu:HD1892 hypothetical protein YP_001343480.1 PFAM: Chloride channel core; KEGG: nme:NMB0982 chloride channel protein-related protein YP_001343481.1 TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: hit:NTHI1036 glutamine synthetase YP_001343482.1 TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; KEGG: msu:MS0263 predicted membrane GTPase involved in stress response YP_001343483.1 KEGG: yen:YE0825 hypothetical protein YP_001343484.1 PFAM: carbohydrate kinase FGGY; KEGG: yen:YE0824 glycerol kinase YP_001343485.1 PFAM: Transketolase central region; Transketolase domain protein; KEGG: eca:ECA1951 putative transketolase C-terminal section YP_001343486.1 PFAM: Transketolase domain protein; KEGG: yen:YE0822 putative N-terminal region of transketolase YP_001343487.1 PFAM: inner-membrane translocator; KEGG: eca:ECA1949 putative sugar ABC transporter, permease protein YP_001343488.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE0820 putative sugar ABC transporter, ATP-binding protein YP_001343489.1 KEGG: yen:YE0819 putative lipoprotein YP_001343490.1 PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: yps:YPTB0812 ABC transporter, periplasmic sugar binding protein YP_001343491.1 PFAM: putative sugar-binding domain protein; KEGG: eca:ECA1954 putative transcriptional regulator YP_001343492.1 DHBP synthase; functions during riboflavin biosynthesis YP_001343493.1 TIGRFAM: aminoacyl-histidine dipeptidase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: hso:HS_0004 Xaa-His dipeptidase (aminoacyl-histidine dipeptidase) YP_001343494.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_001343495.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_001343496.1 TIGRFAM: molybdate ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pmu:PM0742 molybdenum transport ATP-binding protein YP_001343497.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001343498.1 TIGRFAM: anion transporter; PFAM: sodium/sulphate symporter; Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: hit:NTHI0027 hypothetical protein YP_001343499.1 PFAM: protein of unknown function DUF453; KEGG: pol:Bpro_4551 protein of unknown function DUF453 YP_001343500.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_001343501.1 PFAM: regulatory protein GntR HTH; UbiC transcription regulator-associated domain protein; KEGG: pcr:Pcryo_1823 transcriptional regulator, GntR family YP_001343502.1 PFAM: Glutathione S-transferase domain; KEGG: msu:MS2085 glutathione-S-transferases YP_001343503.1 TIGRFAM: diaminopimelate decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: msu:MS2084 diaminopimelate decarboxylase YP_001343505.1 PFAM: diacylglycerol kinase; KEGG: msu:MS0242 diacylglycerol kinase YP_001343506.1 TIGRFAM: RelA/SpoT family protein; PFAM: amino acid-binding ACT domain protein; TGS domain protein; RelA/SpoT domain protein; KEGG: msu:MS0241 guanosine polyphosphate pyrophosphohydrolases/synthetases YP_001343507.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_001343508.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001343509.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_001343510.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_001343511.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_001343512.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_001343513.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_001343514.1 PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: pmu:PM0151 Rbs repressor homolog YP_001343515.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001343516.1 PFAM: protein of unknown function DUF179; KEGG: pmu:PM1869 putative transcriptional regulator YP_001343517.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001343518.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate YP_001343519.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_001343520.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor YP_001343521.1 PFAM: Antibiotic biosynthesis monooxygenase; KEGG: mma:MM1583 hypothetical protein YP_001343522.1 TIGRFAM: formate acetyltransferase; PFAM: formate C-acetyltransferase glycine radical; pyruvate formate-lyase PFL; KEGG: msu:MS0401 pyruvate-formate lyase YP_001343523.1 PFAM: formate/nitrite transporter; KEGG: hso:HS_1135 formate transporter YP_001343524.1 PFAM: histidine triad (HIT) protein; KEGG: pmu:PM0073 hit-like protein, putative YP_001343525.1 KEGG: msu:MS0397 hypothetical protein YP_001343526.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_001343527.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_001343528.1 PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: rsp:RSP_3384 mandelate racemase/muconate lactonizing enzyme family protein YP_001343529.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: stm:STM0764 transcriptional regulator YP_001343530.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: msu:MS1689 LysR protein YP_001343531.1 KEGG: msu:MS1688 hypothetical protein YP_001343532.1 PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: msu:MS2252 lysine efflux permease YP_001343533.1 PFAM: ribulose-phosphate 3-epimerase; KEGG: msu:MS2330 pentose-5-phosphate-3-epimerase YP_001343534.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_001343535.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001343536.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001343537.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001343538.1 PFAM: RNA-binding S4 domain protein; KEGG: msu:MS2264 ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) YP_001343539.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001343540.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: msu:MS1568 DltE protein YP_001343541.1 TIGRFAM: 3'(2'),5'-bisphosphate nucleotidase; PFAM: inositol monophosphatase; KEGG: hit:NTHI0687 CysQ YP_001343542.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001343543.1 TIGRFAM: 6-phosphogluconolactonase; PFAM: glucosamine/galactosamine-6-phosphate isomerase; KEGG: msu:MS0015 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase YP_001343544.1 KEGG: hit:NTHI1855 hypothetical protein YP_001343545.1 TIGRFAM: aspartate racemase; PFAM: Asp/Glu racemase; KEGG: msu:MS0014 RacX protein YP_001343546.1 KEGG: hso:HS_1231 hypothetical protein YP_001343547.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001343548.1 KEGG: msu:MS0012 hypothetical protein YP_001343549.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001343550.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate YP_001343551.1 negative regulator of ulaG and ulaABCDEF YP_001343552.1 KEGG: msu:MS0023 predicted Zn-dependent hydrolases of the beta-lactamase fold YP_001343553.1 PFAM: phosphotransferase system lactose/cellobiose-specific IIB subunit; putative sugar-specific permease SgaT/UlaA; KEGG: msu:MS0022 uncharacterized BCR YP_001343554.1 PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; KEGG: hdu:HD1859 PTS system Enzyme II-A permease component YP_001343555.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_001343556.1 PFAM: peptidylprolyl isomerase FKBP-type; KEGG: msu:MS2199 fKBP-type peptidyl-prolyl cis-trans isomerases 2 YP_001343557.1 PFAM: protein of unknown function DUF541; KEGG: msu:MS2198 hypothetical protein YP_001343558.1 PFAM: protein of unknown function DUF1260; KEGG: hit:NTHI0823 hypothetical protein YP_001343559.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001343560.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_001343561.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_001343562.1 PFAM: protein of unknown function DUF339; KEGG: hso:HS_1604 hypothetical protein YP_001343563.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_001343564.1 PFAM: Anti sigma-E protein RseA family protein; Anti sigma-E protein RseA domain protein; KEGG: msu:MS2229 negative regulator of sigma E activity YP_001343565.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_001343566.1 PFAM: Positive regulator of sigma(E) RseC/MucC; KEGG: msu:MS2231 positive regulator of sigma E activity YP_001343567.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001343568.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001343569.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001343570.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_001343571.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001343572.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001343573.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS0394 ABC-type multidrug/protein/lipid transport system, ATPase component YP_001343574.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001343575.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001343576.1 TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase; KEGG: msu:MS1967 site-specific DNA methylase YP_001343577.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001343578.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001343579.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001343580.1 PFAM: regulatory protein IclR; Transcriptional regulator IclR; KEGG: msu:MS0055 IclR protein YP_001343581.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate YP_001343582.1 PFAM: conserved hypothetical protein 22; KEGG: msu:MS0053 EbgC protein YP_001343583.1 PFAM: Tripartite ATP-independent periplasmic transporter DctQ component; KEGG: msu:MS0052 hypothetical protein YP_001343584.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: msu:MS0051 hypothetical protein YP_001343585.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit; KEGG: msu:MS0050 DctP protein YP_001343586.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit; KEGG: msu:MS0049 DctP protein YP_001343587.1 PFAM: carbohydrate kinase FGGY; KEGG: msu:MS0048 sugar (pentulose and hexulose) kinases YP_001343588.1 PFAM: Bile acid:sodium symporter; KEGG: msu:MS0521 hypothetical protein YP_001343589.1 PFAM: MscS Mechanosensitive ion channel; KEGG: msu:MS2333 MscS protein YP_001343590.1 PFAM: alpha/beta hydrolase fold; KEGG: hin:HI0645 lysophospholipase L2 YP_001343591.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001343592.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001343593.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001343594.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001343595.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001343596.1 PFAM: TfoX domain protein; KEGG: pmu:PM1558 transformation protein, putative YP_001343597.1 PFAM: sodium:neurotransmitter symporter; KEGG: msu:MS2382 Na+-dependent transporters of the SNF family YP_001343598.1 PFAM: protein of unknown function DUF1234; KEGG: msu:MS2381 predicted esterase of the alpha/beta hydrolase fold YP_001343599.1 TIGRFAM: PTS system, mannose/fructose/sorbose family, IIA subunit; PFAM: PTS system fructose subfamily IIA component; PTS system sorbose subfamily IIB component; KEGG: msu:MS2379 phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB YP_001343600.1 TIGRFAM: PTS system, mannose/fructose/sorbose family, IIC subunit; PFAM: phosphotransferase system PTS sorbose-specific IIC subunit; KEGG: msu:MS2378 PTS system, mannose-specific IIC component YP_001343601.1 TIGRFAM: PTS system, mannose/fructose/sorbose family, IID subunit; PFAM: PTS system mannose/fructose/sorbose family IID component; KEGG: msu:MS2377 PTS system, mannose-specific IID component YP_001343602.1 KEGG: msu:MS2376 hypothetical protein YP_001343603.1 TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; KEGG: hin:HI0851 molybdopterin-guanine dinucleotide biosynthesis protein B YP_001343604.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: pmu:PM1784 hypothetical HI0852 YP_001343605.1 PFAM: MgtC/SapB transporter; KEGG: pmu:PM1753 putative Mg2+ transporter-C (MgtC) family protein YP_001343606.1 KEGG: hit:NTHI0559 competence protein F YP_001343607.1 PFAM: NUDIX hydrolase; KEGG: msu:MS2341 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_001343608.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001343609.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_001343610.1 TIGRFAM: DNA-3-methyladenine glycosylase I; PFAM: methyladenine glycosylase; KEGG: hin:HI0654 DNA-3-methyladenine glycosidase I YP_001343611.1 PFAM: extracellular solute-binding protein family 3; KEGG: msu:MS1277 ABC-type amino acid transport system, periplasmic component YP_001343612.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS1276 ABC-type amino acid transport system, permease component YP_001343613.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS1275 ABC-type polar amino acid transport system, ATPase component YP_001343614.1 TIGRFAM: sodium ion-translocating decarboxylase, beta subunit; PFAM: Na+transporting methylmalonyl-CoA/oxaloacetate decarboxylase beta subunit; KEGG: msu:MS0038 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit YP_001343615.1 catalyzes the formation of pyruvate from oxaloacetate YP_001343616.1 catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide YP_001343617.1 TIGRFAM: anion transporter; PFAM: Arsenical pump membrane protein; sodium/sulphate symporter; C4-dicarboxylate anaerobic carrier; Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: hdu:HD0866 possible sodium/sulphate transporter YP_001343618.1 TIGRFAM: cytidyltransferase-related domain; citrate lyase ligase; PFAM: GCN5-related N-acetyltransferase; Citrate lyase ligase domain protein; KEGG: fnu:FN0319 citrate (pro-3S)-lyase ligase YP_001343619.1 KEGG: msu:MS2305 hypothetical protein YP_001343620.1 PFAM: protein of unknown function DUF413; KEGG: msu:MS2060 hypothetical protein YP_001343621.1 PFAM: DSBA oxidoreductase; KEGG: hit:NTHI1012 thiol:disulfide interchange protein DsbA YP_001343622.1 PFAM: protein of unknown function DUF1040; KEGG: msu:MS2058 hypothetical protein YP_001343623.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_001343624.1 PFAM: aldo/keto reductase; KEGG: msu:MS2075 ARA1 protein YP_001343625.1 amylomaltase; acts to release glucose from maltodextrins YP_001343626.1 TIGRFAM: glycogen/starch/alpha-glucan phosphorylase; PFAM: glycosyl transferase family 35; KEGG: msu:MS2073 glucan phosphorylase YP_001343627.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_001343628.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_001343629.1 with MalKFE is involved in the transport of maltose into the cell YP_001343630.1 with MalKGE is involved in maltose transport into the cell YP_001343631.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_001343632.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_001343633.1 with malEFG is involved in import of maltose/maltodextrin YP_001343634.1 PFAM: alpha amylase catalytic region; SMART: alpha amylase catalytic sub domain; KEGG: pat:Patl_2810 alpha amylase, catalytic region YP_001343635.1 porin involved in the transport of maltose and maltodextrins YP_001343636.1 PFAM: Maltose operon periplasmic; KEGG: msu:MS2065 maltose operon periplasmic protein YP_001343637.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: msu:MS2344 predicted hydrolases of the HAD superfamily YP_001343638.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_001343639.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001343640.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001343641.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001343642.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001343643.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001343644.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001343645.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001343646.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_001343647.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001343648.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001343649.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_001343650.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001343651.1 PFAM: SUA5/yciO/yrdC domain; KEGG: hin:HI0656 hypothetical protein YP_001343652.1 PFAM: DNA topoisomerase type IA zn finger domain protein; KEGG: msu:MS0131 Zn-finger domain associated with topoisomerase type I YP_001343653.1 PFAM: protein of unknown function DUF195; KEGG: msu:MS0130 hypothetical protein YP_001343654.1 PFAM: D-tyrosyl-tRNA(Tyr) deacylase; KEGG: hin:HI0670 D-tyrosyl-tRNA(Tyr) deacylase YP_001343655.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_001343656.1 PFAM: SEC-C motif domain protein; KEGG: msu:MS0033 hypothetical protein YP_001343657.1 PFAM: protein of unknown function DUF853 NPT hydrolase putative; SMART: AAA ATPase; KEGG: pmu:PM1435 hypothetical E.coli YP_001343658.1 This protein performs the mismatch recognition step during the DNA repair process YP_001343659.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_001343660.1 TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: msu:MS2081 superfamily II DNA helicase YP_001343661.1 KEGG: msu:MS0269 hypothetical protein YP_001343662.1 heat shock protein involved in degradation of misfolded proteins YP_001343663.1 heat shock protein involved in degradation of misfolded proteins YP_001343664.1 PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: msu:MS0292 Hmp protein YP_001343665.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_001343666.1 TIGRFAM: HemY protein; PFAM: HemY domain protein; KEGG: pmu:PM1815 hemY protein YP_001343667.1 PFAM: protein of unknown function DUF513 hemX; KEGG: msu:MS0274 uncharacterized BCR YP_001343668.1 PFAM: Uroporphyrinogen III synthase HEM4; KEGG: msu:MS0275 uroporphyrinogen-III synthase YP_001343669.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001343670.1 PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: msu:MS1531 PurR protein YP_001343671.1 PFAM: nucleoside:H symporter; major facilitator superfamily MFS_1; KEGG: msu:MS1530 ProP protein YP_001343672.1 PFAM: AP endonuclease 2 domain protein; Xylose isomerase domain protein TIM barrel; KEGG: msu:MS1529 IolE protein YP_001343673.1 PFAM: Semialdehyde dehydrogenase NAD - binding; oxidoreductase domain protein; Oxidoreductase domain; homoserine dehydrogenase NAD-binding; KEGG: msu:MS1528 MviM protein YP_001343674.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_001343675.1 PFAM: regulatory protein LuxR; response regulator receiver; KEGG: hso:HS_0042 nitrate/nitrite response regulator protein YP_001343676.1 PFAM: surface antigen (D15); surface antigen variable number repeat protein; KEGG: msu:MS0285 predicted outer membrane protein YP_001343677.1 PFAM: protein of unknown function DUF490; KEGG: msu:MS0286 hypothetical protein YP_001343678.1 PFAM: Ppx/GppA phosphatase; KEGG: msu:MS0287 exopolyphosphatase YP_001343679.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit; KEGG: gka:GK1974 C4-dicarboxylate transport system (C4-dicarboxylate-binding protein) YP_001343680.1 PFAM: Tripartite ATP-independent periplasmic transporter DctQ component; KEGG: gka:GK1973 transporter YP_001343681.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: C4-dicarboxylate anaerobic carrier; Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: gka:GK1972 transporter YP_001343682.1 PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: bsu:BG13207 similar to alcohol dehydrogenase YP_001343683.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001343684.1 PFAM: Mannitol dehydrogenase domain; Mannitol dehydrogenase rossman domain; KEGG: tte:TTE1940 mannitol-1-phosphate/altronate dehydrogenase YP_001343685.1 PFAM: regulatory protein GntR HTH; GntR domain protein; KEGG: bha:BH1062 transcriptional regulator (GntR family) YP_001343686.1 PFAM: PfkB domain protein; KEGG: msu:MS0545 sugar kinases, ribokinase family YP_001343687.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_001343688.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_001343689.1 TIGRFAM: CRISPR-associated protein, Csn1 family; KEGG: pmu:PM1127 unknown YP_001343690.1 TIGRFAM: CRISPR-associated protein Cas1; KEGG: pmu:PM1126 unknown YP_001343691.1 TIGRFAM: CRISPR-associated protein Cas2; KEGG: pmu:PM1125 unknown YP_001343692.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_001343693.1 PFAM: protein of unknown function DUF414; KEGG: msu:MS0230 hypothetical protein YP_001343694.1 KEGG: msu:MS0229 hypothetical protein YP_001343695.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001343696.1 KEGG: pmu:PM0673 hypothetical HI1326 YP_001343697.1 catalyzes the O-acetylation of serine YP_001343698.1 PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; KEGG: pmu:PM1431 glycerol-3-phosphate dehydrogenase (NAD+) YP_001343699.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001343700.1 PFAM: Rhodanese domain protein; KEGG: msu:MS2215 PspE protein YP_001343701.1 putative ABC transporter, membrane protein YP_001343702.1 TIGRFAM: cell division ATP-binding protein FtsE; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS0008 predicted ATPase involved in cell division YP_001343703.1 TIGRFAM: glutaredoxin-family domain protein; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; glutaredoxin; Redoxin domain protein; KEGG: pmu:PM1347 membrane protein, putative YP_001343704.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_001343705.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_001343706.1 PFAM: protein of unknown function DUF904; KEGG: msu:MS2253 hypothetical protein YP_001343707.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001343708.1 PFAM: pentapeptide repeat protein; KEGG: cte:CT2067 pentapeptide repeat family protein YP_001343709.1 PFAM: Sel1 domain protein repeat-containing protein; KEGG: zmo:ZMO0068 hypothetical protein YP_001343710.1 PFAM: Peptidoglycan-binding domain 1 protein; KEGG: ajs:Ajs_1969 hypothetical protein YP_001343712.1 KEGG: ajs:Ajs_1971 hypothetical protein YP_001343714.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_001343715.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001343716.1 PFAM: iron-containing alcohol dehydrogenase; KEGG: msu:MS1802 alcohol dehydrogenase IV YP_001343717.1 SMART: Rhodanese domain protein; KEGG: msu:MS2248 PspE protein YP_001343718.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_001343719.1 KEGG: msu:MS2246 hypothetical protein YP_001343720.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_001343721.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure YP_001343722.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001343723.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001343724.1 TIGRFAM: CrcB protein; PFAM: Camphor resistance CrcB protein; KEGG: msu:MS2226 integral membrane protein possibly involved in chromosome condensation YP_001343725.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: msu:MS2225 predicted hydrolases of the HAD superfamily YP_001343726.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_001343727.1 KEGG: msu:MS2222 acetolactate synthase, small subunit YP_001343728.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001343729.1 PFAM: zinc/iron permease; KEGG: ssa:SSA_1413 GufA-like protein, putative YP_001343730.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_001343731.1 related to GcvT; KEGG: msu:MS0254 predicted aminomethyltransferase related to GcvT YP_001343732.1 PFAM: YicC domain protein; domain of unknown function DUF1732; KEGG: msu:MS0253 hypothetical protein YP_001343733.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001343734.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001343735.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001343737.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_001343738.1 KEGG: nme:NMB1475 hypothetical protein YP_001343739.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_001343740.1 TIGRFAM: putative endoribonuclease L-PSP; PFAM: Endoribonuclease L-PSP; KEGG: msu:MS2189 putative translation initiation inhibitor YP_001343741.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_001343742.1 PFAM: protein of unknown function DUF548; KEGG: msu:MS2368 SmtA protein YP_001343743.1 PFAM: pseudouridine synthase; KEGG: msu:MS2342 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_001343744.1 PFAM: extracellular solute-binding protein family 1; KEGG: msu:MS2292 spermidine/putrescine-binding periplasmic protein YP_001343745.1 PFAM: Tannase and feruloyl esterase; KEGG: msu:MS2241 hypothetical protein YP_001343746.1 TIGRFAM: PTS system, glucitol/sorbitol-specific, IIC subunit; PFAM: PTS system protein II sorbitol-specific factor; KEGG: hso:HS_0679 PTS system, glucitol/sorbitol-specific IIC2 component YP_001343747.1 TIGRFAM: PTS system, glucitol/sorbitol-specific, IIBC subunit; PFAM: Sorbitol phosphotransferase protein II domain protein; KEGG: hso:HS_0678 PTS system, glucitol/sorbitol-specific IIBC component YP_001343748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001343749.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate YP_001343750.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_001343751.1 regulator for glucitol utilization YP_001343752.1 regulates genes involved in glucitol utilization YP_001343753.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_001343754.1 TIGRFAM: selenocysteine-specific translation elongation factor; small GTP-binding protein; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; Elongation factor SelB winged helix 2; Elongation factor SelB winged helix 3; KEGG: msu:MS2339 selenocysteine-specific translation elongation factor YP_001343755.1 PFAM: protein of unknown function DUF1440; KEGG: msu:MS2340 hypothetical protein YP_001343756.1 TIGRFAM: putative methyltransferase; PFAM: conserved hypothetical protein 95; KEGG: hit:NTHI0928 predicted N6-adenine-specific methylase YP_001343757.1 TIGRFAM: signal recognition particle-docking protein FtsY; PFAM: GTP-binding signal recognition particle SRP54 G- domain; GTP-binding signal recognition particle SRP54 helical bundle; SMART: AAA ATPase; KEGG: msu:MS0140 signal recognition particle GTPase YP_001343758.1 KEGG: hso:HS_0923 hypothetical protein YP_001343759.1 transports degraded pectin products into the bacterial cell YP_001343760.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001343761.1 KEGG: hso:HS_1544 hypothetical protein YP_001343762.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001343763.1 PFAM: sodium/glutamate symporter; KEGG: msu:MS0030 Na+/glutamate symporter YP_001343764.1 PFAM: DinI family protein YP_001343765.1 PFAM: Chloride channel core; KEGG: msu:MS2051 EriC protein YP_001343766.1 TIGRFAM: PTS system, mannitol-specific IIC subunit; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; phosphotransferase system EIIC; phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: msu:MS0411 phosphotransferase system, mannitol-specific IIBC component YP_001343767.1 PFAM: Mannitol dehydrogenase domain; Mannitol dehydrogenase rossman domain; KEGG: msu:MS0410 mannitol-1-phosphate/altronate dehydrogenases YP_001343768.1 Acts as a repressor of the mtlAD operon YP_001343769.1 PFAM: ribosomal protein S10; KEGG: yps:YPTB3699 30S ribosomal protein S10 YP_001343770.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001343771.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001343772.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001343773.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001343774.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001343775.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001343776.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001343777.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001343778.1 one of the stabilizing components for the large ribosomal subunit YP_001343779.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001343780.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001343781.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001343782.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001343783.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001343784.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001343785.1 PFAM: ribosomal protein L6; KEGG: pmu:PM1400 50S ribosomal protein L6 YP_001343786.1 binds 5S rRNA along with protein L5 and L25 YP_001343787.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001343788.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001343789.1 late assembly protein YP_001343790.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001343791.1 PFAM: ribosomal protein L36; KEGG: msu:MS2027 ribosomal protein L36 YP_001343792.1 PFAM: ribosomal protein S13; KEGG: msu:MS2026 ribosomal protein S13 YP_001343793.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001343794.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001343795.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001343796.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001343797.1 PFAM: metallophosphoesterase; KEGG: pmu:PM1388 hypothetical HI0762 YP_001343798.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_001343799.1 DHBP synthase; functions during riboflavin biosynthesis YP_001343800.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_001343801.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_001343802.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_001343803.1 PFAM: carbohydrate kinase FGGY; KEGG: msu:MS0059 XylB protein YP_001343804.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_001343805.1 PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: msu:MS2375 transcriptional regulators YP_001343806.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter YP_001343807.1 PFAM: inner-membrane translocator; KEGG: hin:HI1109 D-xylose transport system permease protein YP_001343808.1 with XylFH is part of the high affinity xylose ABC transporter YP_001343809.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity YP_001343810.1 catalyzes the interconversion of D-xylose to D-xylulose YP_001343811.1 TIGRFAM: xylulokinase; PFAM: carbohydrate kinase FGGY; KEGG: msu:MS2372 sugar (pentulose and hexulose) kinases YP_001343812.1 TIGRFAM: TIM-barrel protein, yjbN family; PFAM: dihydrouridine synthase DuS; KEGG: pmu:PM1418 tRNA-dihydrouridine synthase A YP_001343813.1 catalyzes the formation of asparagine from aspartate and ammonia YP_001343814.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_001343815.1 TIGRFAM: Mg chelatase, subunit ChlI; PFAM: magnesium chelatase ChlI subunit; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase; KEGG: hit:NTHI1282 competence protein ComM YP_001343816.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001343817.1 PFAM: transmembrane pair domain protein; KEGG: msu:MS2245 hypothetical protein YP_001343818.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001343819.1 PFAM: phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: msu:MS0150 phosphotransferase system component IIB of unknown specificity YP_001343820.1 PFAM: SirA family protein; KEGG: msu:MS0173 predicted transcriptional regulators YP_001343821.1 PFAM: protein of unknown function UPF0029; Domain of unknown function DUF1949; KEGG: msu:MS0174 hypothetical protein YP_001343822.1 TIGRFAM: potassium uptake protein, TrkH family; PFAM: cation transporter; KEGG: msu:MS0175 trk-type K+ transport systems, membrane components YP_001343823.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_001343824.1 PFAM: protein of unknown function UPF0066; KEGG: hit:NTHI0638 hypothetical protein YP_001343825.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001343826.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_001343827.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001343828.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001343829.1 Essential for efficient processing of 16S rRNA YP_001343830.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001343831.1 PFAM: glycosyl transferase family 2; KEGG: hhe:HH0773 hypothetical protein YP_001343832.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001343833.1 PFAM: peptidase M48 Ste24p; KEGG: msu:MS0437 HtpX protein YP_001343834.1 PFAM: glycosyl transferase group 1; KEGG: ngo:NGO2072 lipooligosaccharide glycosyl transferase G YP_001343835.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001343836.1 PFAM: glycosyl transferase family 25; KEGG: hso:HS_0638 Lob1 protein YP_001343837.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001343838.1 TIGRFAM: cell division protein FtsN; PFAM: Sporulation domain protein; KEGG: msu:MS0450 cell division protein YP_001343839.1 PFAM: regulatory protein TetR; KEGG: msu:MS0453 AcrR protein YP_001343840.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: msu:MS0454 AcrA protein YP_001343841.1 PFAM: acriflavin resistance protein; KEGG: msu:MS0456 cation/multidrug efflux pump YP_001343842.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_001343843.1 PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: msu:MS0247 NapF protein YP_001343844.1 PFAM: ribonuclease T2; KEGG: hit:NTHI0652 probable ribonuclease I YP_001343845.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001343846.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_001343847.1 PFAM: O-antigen polymerase; KEGG: msu:MS0243 RfaL protein YP_001343848.1 PFAM: protein of unknown function DUF469; KEGG: msu:MS0319 hypothetical protein YP_001343849.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001343850.1 TIGRFAM: A/G-specific adenine glycosylase; PFAM: HhH-GPD family protein; SMART: iron-sulfur cluster loop; KEGG: hso:HS_1667 A/G-specific adenine glycosylase YP_001343851.1 PFAM: Fe(II) trafficking protein YggX; KEGG: hit:NTHI0920 hypothetical protein YP_001343852.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001343853.1 PFAM: YfbU family protein; KEGG: pmu:PM1500 hypothetical E.coli YP_001343854.1 PFAM: VacJ family lipoprotein; KEGG: msu:MS2239 surface lipoprotein YP_001343855.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001343856.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001343857.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001343858.1 TIGRFAM: choline/carnitine/betaine transporter; PFAM: BCCT transporter; KEGG: msu:MS0227 choline-glycine betaine transporter YP_001343859.1 PFAM: Semialdehyde dehydrogenase NAD - binding; oxidoreductase domain protein; Oxidoreductase domain; KEGG: pmu:PM0652 hypothetical E.coli YP_001343860.1 PFAM: Glutathione S-transferase domain; KEGG: msu:MS0257 Gst protein YP_001343861.1 TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein; KEGG: sab:SAB0109 probable cation-efflux system membrane protein YP_001343862.1 PFAM: 6-phosphogluconate dehydrogenase NAD-binding; KEGG: nmc:NMC1504 hypothetical protein YP_001343863.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: msu:MS2097 NemA protein YP_001343864.1 TIGRFAM: lipoyltransferase and lipoate-protein ligase; PFAM: biotin/lipoate A/B protein ligase; KEGG: msu:MS1058 lipoate-protein ligase A YP_001343865.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001343866.1 PFAM: sulfatase; KEGG: vfi:VF0131 phosphoglycerol transferase MdoB and related proteins, alkaline phosphatase superfamily YP_001343867.1 TIGRFAM: transcription-repair coupling factor; PFAM: helicase domain protein; transcription factor CarD; TRCF domain protein; type III restriction protein res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: msu:MS0216 transcription-repair coupling factor - superfamily II helicase YP_001343868.1 TIGRFAM: ribosomal subunit interface protein; PFAM: sigma 54 modulation protein/ribosomal protein S30EA; KEGG: hso:HS_0462 ribosome-associated protein Y YP_001343869.1 PFAM: Peptidoglycan-binding LysM; peptidase M23B; KEGG: hit:NTHI0830 outer membrane antigenic lipoprotein B YP_001343870.1 KEGG: msu:MS2270 hypothetical protein YP_001343871.1 PFAM: SNARE associated Golgi protein; KEGG: msu:MS2271 hypothetical protein YP_001343872.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001343873.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001343874.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: msu:MS0611 lactoylglutathione lyase and related lyases YP_001343875.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_001343876.1 TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein; KEGG: hit:NTHI1157 smf YP_001343877.1 TIGRFAM: pyruvate formate-lyase activating enzyme; PFAM: Radical SAM domain protein; KEGG: hso:HS_1147 pyruvate formate-lyase 1 activating enzyme YP_001343878.1 PFAM: protein of unknown function DUF533; KEGG: msu:MS2177 hypothetical protein YP_001343879.1 KEGG: msu:MS2317 hypothetical protein YP_001343880.1 PFAM: protein of unknown function DUF610 YibQ; KEGG: msu:MS2319 hypothetical protein YP_001343881.1 PFAM: peptidase M23B; KEGG: msu:MS2320 NlpD protein YP_001343882.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001343883.1 TIGRFAM: lipopolysaccharide heptosyltransferase II; PFAM: glycosyl transferase family 9; KEGG: msu:MS2260 ADP-heptoseLPS heptosyltransferase YP_001343884.1 KEGG: msu:MS0375 hypothetical protein YP_001343885.1 PFAM: protein of unknown function DUF328; KEGG: msu:MS0374 hypothetical protein YP_001343886.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001343887.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_001343888.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001343889.1 TIGRFAM: signal peptidase I; PFAM: peptidase S24 S26A and S26B; KEGG: msu:MS0370 signal peptidase I YP_001343890.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001343891.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001343892.1 TIGRFAM: transaldolase; PFAM: Transaldolase; KEGG: msu:MS2355 transaldolase YP_001343893.1 PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; PRD domain protein; Helix-turn-helix type 11 domain protein; KEGG: sak:SAK_1762 PRD domain/PTS system IIA domain protein YP_001343894.1 TIGRFAM: PTS system, fructose subfamily, IIA subunit; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; KEGG: tte:TTE2586 phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) YP_001343895.1 TIGRFAM: PTS system, fructose-specific, IIB subunnit; PFAM: phosphotransferase system PTS fructose-specific IIB subunit; KEGG: cvi:CV2310 PTS system, fructose-like-2 IIB component 1 YP_001343896.1 TIGRFAM: PTS system, fructose subfamily, IIC subunit; PFAM: phosphotransferase system EIIC; KEGG: btl:BALH_4764 phosphotransferase system (PTS) mannose-specific enzyme IIBCA YP_001343897.1 KEGG: lmf:LMOf2365_0663 hypothetical protein YP_001343898.1 PFAM: RNA binding S1 domain protein; SMART: Resolvase RNase H domain protein fold; KEGG: hit:NTHI0701 predicted transcriptional accessory protein YP_001343899.1 PFAM: sodium/hydrogen exchanger; KEGG: msu:MS0136 NHAP-type Na+/H+ and K+/H+ antiporters YP_001343900.1 PFAM: iron-containing alcohol dehydrogenase; KEGG: msu:MS2190 alcohol dehydrogenase IV YP_001343901.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_001343902.1 TIGRFAM: phosphoglycerate transporter; glycerol-3-phosphate transporter; PFAM: major facilitator superfamily MFS_1; KEGG: msu:MS1991 sugar phosphate permease YP_001343903.1 PFAM: multiple antibiotic resistance (MarC)-related protein; KEGG: pmu:PM1581 putative multiple antibiotic resistance protein YP_001343904.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS0137 ATPase components of ABC transporters with duplicated ATPase domains YP_001343905.1 KEGG: hdu:HD1891 possible drug resistance protein YP_001343906.1 PFAM: Uncharacterized lipoprotein; KEGG: msu:MS0312 uncharacterized lipoprotein YP_001343907.1 PFAM: BolA family protein; KEGG: msu:MS0311 stress-induced morphogen (activity unknown) YP_001343908.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001343909.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001343910.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001343911.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm YP_001343912.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. YP_001343913.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm YP_001343914.1 PFAM: ApbE family lipoprotein; KEGG: msu:MS0303 membrane-associated lipoprotein involved in thiamine biosynthesis YP_001343915.1 PFAM: protein of unknown function DUF539; KEGG: msu:MS0302 hypothetical protein YP_001343916.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001343917.1 KEGG: msu:MS0357 predicted acetyltransferase YP_001343918.1 TIGRFAM: dephospho-CoA kinase; PFAM: Dephospho-CoA kinase; protein of unknown function DUF329; KEGG: hit:NTHI1055 dephospho-CoA kinase YP_001343919.1 PFAM: peptidase A24A prepilin type IV; KEGG: hso:HS_0458 prepilin peptidase YP_001343920.1 PFAM: type II secretion system protein; KEGG: hso:HS_0457 protein transport protein YP_001343921.1 PFAM: type II secretion system protein E; General secretory system II protein E domain protein; KEGG: hit:NTHI0408 putative type IV pilin secretion protein YP_001343922.1 KEGG: pmu:PM0084 prepilin peptidase dependent protein D YP_001343923.1 PFAM: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: hin:HI0300 ampD protein homolog YP_001343924.1 KEGG: msu:MS0366 hypothetical protein YP_001343925.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: hso:HS_0674 conserved phosphatase YP_001343926.1 with ArtPQJI acts to transport arginine across the inner membrane YP_001343927.1 with ArtPMJI transports arginine across the inner membrane YP_001343928.1 TIGRFAM: cationic amino acid ABC transporter, periplasmic binding protein; PFAM: extracellular solute-binding protein family 3; SMART: ionotropic glutamate receptor; KEGG: msu:MS0220 ABC-type amino acid transport system, periplasmic component YP_001343929.1 With ArtMQJI transports arginine across the inner membrane YP_001343930.1 PFAM: dihydrouridine synthase DuS; KEGG: hin:HI0270 tRNA-dihydrouridine synthase YP_001343931.1 KEGG: msu:MS1903 hypothetical protein YP_001343932.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_001343933.1 TIGRFAM: purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1; KEGG: hso:HS_0288 purine-nucleoside phosphorylase YP_001343934.1 TIGRFAM: phosphopentomutase; PFAM: metalloenzyme domain protein; Phosphopentomutase domain protein; KEGG: plu:plu0521 phosphopentomutase (phosphodeoxyribomutase) YP_001343935.1 TIGRFAM: nucleoside transporter; PFAM: Na dependent nucleoside transporter; nucleoside recognition domain protein; Na dependent nucleoside transporter domain protein; KEGG: msu:MS1897 nucleoside permease YP_001343936.1 PFAM: protein of unknown function DUF161; KEGG: msu:MS1896 uncharacterized membrane protein YP_001343937.1 TIGRFAM: aromatic amino acid transporter; PFAM: aromatic amino acid permease; KEGG: msu:MS1895 amino acid permeases YP_001343938.1 PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: pmu:PM1194 hypothetical HI0912 YP_001343939.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_001343940.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001343941.1 PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: cps:CPS_3142 transporter, LysE family YP_001343942.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001343943.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_001343945.1 KEGG: msu:MS1885 glutamine amidotransferase YP_001343946.1 PFAM: GCN5-related N-acetyltransferase; KEGG: san:gbs0247 hypothetical protein YP_001343947.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_001343948.1 TIGRFAM: NAD+ synthetase; PFAM: NAD synthase; KEGG: msu:MS1888 NAD synthase YP_001343949.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001343950.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001343951.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001343952.1 PFAM: protein of unknown function DUF997; KEGG: msu:MS1787 hypothetical protein YP_001343953.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_001343954.1 TIGRFAM: ribosomal protein L11 methyltransferase; PFAM: methyltransferase small; ribosomal L11 methyltransferase; Methyltransferase type 12; KEGG: hit:NTHI1149 ribosomal protein L11 methyltransferase YP_001343955.1 TIGRFAM: putative TIM-barrel protein, nifR3 family; PFAM: dihydrouridine synthase DuS; dihydroorotate dehydrogenase; KEGG: msu:MS0532 predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family YP_001343956.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_001343957.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_001343958.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001343959.1 TIGRFAM: alkylhydroperoxidase like protein, AhpD family; PFAM: Carboxymuconolactone decarboxylase; KEGG: ssa:SSA_1929 macrophage infectivity potentiator protein, putative YP_001343960.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_001343961.1 PFAM: sulfatase; KEGG: msu:MS1931 hypothetical protein YP_001343962.1 PFAM: Catalase domain protein; KEGG: nmc:NMC0211 catalase YP_001343963.1 Catalyzes the phosphorylation of UMP to UDP YP_001343964.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001343965.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001343966.1 PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: hit:NTHI1027 predicted 5-formyltetrahydrofolate cyclo-ligase YP_001343967.1 PFAM: protein of unknown function DUF710; KEGG: msu:MS0477 hypothetical protein YP_001343968.1 TIGRFAM: yecA family protein; PFAM: protein of unknown function UPF0149; KEGG: msu:MS0478 hypothetical protein YP_001343969.1 PFAM: peptidase M24; peptidase M24B X-Pro dipeptidase/aminopeptidase domain protein; KEGG: msu:MS0479 Xaa-Pro aminopeptidase YP_001343970.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001343971.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001343972.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001343973.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_001343974.1 TIGRFAM: Sec-independent protein translocase, TatC subunit; PFAM: Sec-independent periplasmic protein translocase; KEGG: msu:MS0502 sec-independent protein secretion pathway component TatC YP_001343975.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001343976.1 PFAM: manganese and iron superoxide dismutase; KEGG: pmu:PM0001 superoxide dismutase YP_001343977.1 PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: msu:MS0390 malic enzyme YP_001343978.1 PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: msu:MS0391 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_001343979.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_001343980.1 KEGG: pmu:PM0127 hypothetical HI1126 YP_001343981.1 PFAM: DNA methylase N-4/N-6 domain protein; KEGG: pmu:PM0698 methyltransferase, type III DNA modification enzyme YP_001343982.1 PFAM: type III restriction protein res subunit; KEGG: hdu:HD1690 type III restriction enzyme YP_001343983.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001343984.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_001343985.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001343986.1 KEGG: msu:MS0323 WecD protein YP_001343987.1 PFAM: FKBP-type peptidyl-prolyl isomerase domain protein; peptidylprolyl isomerase FKBP-type; KEGG: msu:MS0157 FKBP-type peptidyl-prolyl cis-trans isomerases 1 YP_001343988.1 PFAM: SlyX family protein; KEGG: msu:MS0156 uncharacterized BCR YP_001343989.1 PFAM: protein of unknown function DUF1375; KEGG: msu:MS0412 hypothetical protein YP_001343990.1 TIGRFAM: ATP-dependent DNA helicase Rep; PFAM: UvrD/REP helicase; KEGG: msu:MS0413 superfamily I DNA and RNA helicases YP_001343991.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; beta-phosphoglucomutase family hydrolase; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: msu:MS0416 hypothetical protein YP_001343992.1 PFAM: transferase hexapeptide repeat containing protein; KEGG: msu:MS0417 WbbJ protein YP_001343993.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_001343994.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_001343995.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001343996.1 TIGRFAM: type IV pilus secretin PilQ; PFAM: type II and III secretion system protein; NolW domain protein; KEGG: msu:MS1970 general secretory pathway protein D YP_001343997.1 KEGG: msu:MS1971 hypothetical protein YP_001343998.1 KEGG: pmu:PM1227 competence C protein, putative YP_001343999.1 PFAM: Fimbrial assembly family protein; KEGG: hit:NTHI0564 competence protein B YP_001344000.1 KEGG: hin:HI0439 competence protein A YP_001344001.1 TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; KEGG: msu:MS1975 membrane carboxypeptidase (penicillin-binding protein) YP_001344002.1 PFAM: protein of unknown function DUF519; KEGG: pmu:PM1234 OrfJ protein, putative YP_001344003.1 TIGRFAM: iojap-like protein; PFAM: Iojap-related protein; KEGG: msu:MS1834 hypothetical protein YP_001344004.1 PFAM: protein of unknown function DUF163; KEGG: msu:MS1833 hypothetical protein YP_001344005.1 PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: msu:MS1832 cell division protein FtsI/penicillin-binding protein 2 YP_001344006.1 TIGRFAM: rod shape-determining protein RodA; PFAM: cell cycle protein; KEGG: msu:MS1831 bacterial cell division membrane protein YP_001344007.1 TIGRFAM: rare lipoprotein A; PFAM: Rare lipoprotein A; KEGG: msu:MS1830 lipoproteins YP_001344008.1 PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: msu:MS1829 D-alanyl-D-alanine carboxypeptidase YP_001344009.1 PFAM: protein of unknown function DUF493; KEGG: hdu:HD2015 hypothetical protein YP_001344010.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001344011.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001344012.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_001344013.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia YP_001344014.1 PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: msu:MS1817 Fe-S-cluster-containing hydrogenase components 1 YP_001344015.1 PFAM: Polysulphide reductase NrfD; KEGG: msu:MS1816 formate-dependent nitrite reductase, membrane component YP_001344016.1 TIGRFAM: cytochrome c-type biogenesis protein CcmF; PFAM: cytochrome c assembly protein; KEGG: msu:MS1815 cytochrome c biogenesis factor YP_001344017.1 TIGRFAM: periplasmic protein thiol--disulphide oxidoreductase DsbE; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: msu:MS1813 thiol-disulfide isomerase and thioredoxins YP_001344018.1 PFAM: cytochrome C biogenesis protein; KEGG: msu:MS1812 uncharacterized protein involved in biosynthesis of c-type cytochromes YP_001344019.1 PFAM: Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: msu:MS1811 TPR-repeat-containing proteins YP_001344020.1 PFAM: HI0933 family protein; FAD dependent oxidoreductase; KEGG: msu:MS1810 predicted flavoproteins YP_001344021.1 PFAM: Methionine synthase vitamin-B12 independent; KEGG: oih:OB1054 hypothetical protein YP_001344022.1 PFAM: dihydrofolate reductase region; KEGG: hin:HI0899 dihydrofolate reductase YP_001344023.1 KEGG: msu:MS1859 hypothetical protein YP_001344024.1 PFAM: protein of unknown function DUF1212; KEGG: msu:MS1860 hypothetical protein YP_001344025.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001344026.1 PFAM: FKBP-type peptidyl-prolyl isomerase domain protein; peptidylprolyl isomerase FKBP-type; KEGG: msu:MS1863 FKBP-type peptidyl-prolyl cis-trans isomerases 1 YP_001344027.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_001344028.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001344029.1 synthesizes RNA primers at the replication forks YP_001344030.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001344031.1 PFAM: CMP/dCMP deaminase zinc-binding; KEGG: msu:MS0404 hypothetical protein YP_001344032.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001344033.1 PFAM: prolipoprotein diacylglyceryl transferase; KEGG: hso:HS_1620 prolipoprotein diacylglyceryl transferase YP_001344034.1 PFAM: protein of unknown function DUF81; KEGG: msu:MS0407 hypothetical protein YP_001344035.1 hydrolyzes diadenosine polyphosphate YP_001344036.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001344037.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001344038.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_001344039.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; SurA domain; KEGG: msu:MS0629 parvulin-like peptidyl-prolyl isomerase YP_001344040.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001344041.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_001344042.1 KEGG: msu:MS0344 hypothetical protein YP_001344043.1 PFAM: transglutaminase domain protein; KEGG: msu:MS0343 hypothetical protein YP_001344044.1 KEGG: msu:MS0342 putative mercuric transport protein YP_001344045.1 PFAM: Heavy metal transport/detoxification protein; KEGG: msu:MS0341 copper chaperone YP_001344046.1 KEGG: tac:Ta0640 hypothetical membrane protein YP_001344047.1 PFAM: GCN5-related N-acetyltransferase; KEGG: lwe:lwe0295 acetyltransferase, GNAT family YP_001344048.1 PFAM: regulatory protein MarR; KEGG: msu:MS2146 MarR protein YP_001344049.1 PFAM: acyltransferase 3; KEGG: msu:MS0340 hypothetical protein YP_001344050.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001344051.1 KEGG: msu:MS1576 hypothetical protein YP_001344052.1 PFAM: Rare lipoprotein B; KEGG: msu:MS0337 rare lipoprotein B YP_001344053.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_001344054.1 TIGRFAM: amino acid carrier protein; PFAM: sodium:alanine symporter; KEGG: msu:MS0353 Na+/alanine symporter YP_001344055.1 PFAM: regulatory protein DeoR; Helix-turn-helix type 11 domain protein; regulatory protein DeoR; KEGG: msu:MS0187 GlpR protein YP_001344056.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001344057.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: msu:MS0191 ProP protein YP_001344058.1 PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region; KEGG: msu:MS0517 hypothetical protein YP_001344059.1 PFAM: cytochrome c assembly protein; KEGG: msu:MS0518 CcmC protein YP_001344060.1 TIGRFAM: signal recognition particle protein; PFAM: GTP-binding signal recognition particle SRP54 G- domain; Signal peptide binding (SRP54) M- domain protein; GTP-binding signal recognition particle SRP54 helical bundle; SMART: AAA ATPase; KEGG: msu:MS0519 signal recognition particle GTPase YP_001344061.1 PFAM: YheO domain protein; KEGG: hso:HS_1636 hypothetical protein YP_001344062.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001344063.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001344064.1 KEGG: hit:NTHI0711 uncharacterized conserved protein involved in oxidation of intracellular sulfur YP_001344065.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001344066.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001344067.1 binds single-stranded DNA at the primosome assembly site YP_001344068.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001344069.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_001344070.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001344071.1 PFAM: Peptidoglycan-binding LysM; transport-associated; KEGG: msu:MS1850 XkdP protein YP_001344072.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001344073.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001344074.1 binds and unfolds substrates as part of the ClpXP protease YP_001344075.1 KEGG: msu:MS1844 ATP-dependent Lon protease, bacterial type; TIGRFAM: ATP-dependent protease La; PFAM: peptidase S16 lon domain protein; AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; SMART: AAA ATPase YP_001344076.1 PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: hit:NTHI0483 penicillin-binding protein 7 homolog precursor YP_001344077.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: msu:MS1843 parvulin-like peptidyl-prolyl isomerase YP_001344078.1 PFAM: YadA domain protein; Haemagluttinin domain protein; Hep_Hag repeat-containing protein; KEGG: bam:Bamb_3834 YadA C-terminal domain protein YP_001344079.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001344080.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001344081.1 KEGG: msu:MS1908 hypothetical protein YP_001344082.1 PFAM: sulfatase; KEGG: msu:MS1909 predicted hydrolase of alkaline phosphatase superfamily YP_001344083.1 PFAM: protein of unknown function DUF1414; KEGG: pmu:PM1884 hypothetical HI0840 YP_001344084.1 PFAM: 37kDa nucleoid-associated protein; KEGG: msu:MS1911 nucleoid-associated protein YP_001344085.1 PFAM: SmpA/OmlA domain protein; KEGG: msu:MS1912 small protein A (tmRNA-binding) YP_001344086.1 PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: msu:MS1913 response regulators consisting of a CheY-like receiver domain and a HTH DNA-binding domain YP_001344087.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_001344088.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_001344089.1 TIGRFAM: isochorismate synthase; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: msu:MS1795 isochorismate synthase YP_001344090.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_001344091.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS1713 uncharacterized ABC-type transport system, ATPase component YP_001344092.1 PFAM: protein of unknown function DUF140; KEGG: msu:MS1712 ABC-type toluene export system, permease component YP_001344093.1 PFAM: Mammalian cell entry related domain protein; KEGG: msu:MS1711 permease component of an ABC-transporter YP_001344094.1 PFAM: toluene tolerance family protein; KEGG: msu:MS1710 uncharacterized periplasmic protein YP_001344095.1 PFAM: Sulfate transporter/antisigma-factor antagonist STAS; KEGG: msu:MS1709 STAS domain protein YP_001344096.1 PFAM: BolA family protein; KEGG: msu:MS1708 BolA protein YP_001344097.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001344098.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: hit:NTHI1422 predicted ABC-type cobalt transport system, ATPase component YP_001344099.1 PFAM: cobalt transport protein; KEGG: hit:NTHI1421 predicted cobalt transport protein YP_001344100.1 catalyzes the ATP-dependent transport of cobalt YP_001344101.1 KEGG: hit:NTHI1419 hypothetical protein YP_001344102.1 KEGG: hit:NTHI1418 putative ABC-type Co2+ transport system, periplasmic component YP_001344103.1 PFAM: regulatory protein MerR; Transcription regulator MerR DNA binding; KEGG: hin:HI1623 zn(II)-responsive regulator homolog YP_001344104.1 PFAM: alanine racemase domain protein; KEGG: hin:HI0090 hypothetical protein YP_001344105.1 PFAM: superoxide dismutase copper/zinc binding; KEGG: pmu:PM1952 superoxide dismutase, Cu-Zn family YP_001344106.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001344107.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001344108.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001344109.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction YP_001344110.1 PFAM: arsenate reductase and related; KEGG: msu:MS0672 ArsC protein YP_001344111.1 PFAM: protein of unknown function DUF1568; KEGG: msu:MS0673 hypothetical protein YP_001344112.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001344113.1 PFAM: peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin; KEGG: msu:MS0675 D-alanyl-D-alanine carboxypeptidase YP_001344114.1 PFAM: protein of unknown function DUF615; KEGG: msu:MS0681 hypothetical protein YP_001344115.1 PFAM: peptidase U62 modulator of DNA gyrase; KEGG: msu:MS0682 predicted Zn-dependent proteases and their inactivated similarity YP_001344116.1 TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: pmu:PM0121 hypoxanthine phosphoribosyltransferase YP_001344117.1 PFAM: AAA-4 family protein; KEGG: plu:plu4904 hypothetical protein YP_001344118.1 PFAM: lipopolysaccharide biosynthesis protein; KEGG: msu:MS0655 hypothetical protein YP_001344119.1 KEGG: msu:MS0656 hypothetical protein YP_001344120.1 PFAM: polysaccharide biosynthesis protein; KEGG: msu:MS0657 membrane protein involved in the export of O-antigen and teichoic acid YP_001344121.1 TIGRFAM: cytidyltransferase-related domain; glycerol-3-phosphate cytidylyltransferase; PFAM: Riboflavin kinase / FAD synthetase; cytidylyltransferase; KEGG: msu:MS0658 cytidylyltransferase YP_001344122.1 PFAM: CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase; KEGG: msu:MS0659 TagB protein YP_001344123.1 KEGG: msu:MS0660 hypothetical protein YP_001344124.1 PFAM: protein of unknown function DUF262; protein of unknown function DUF1524 RloF; KEGG: cch:Cag_0325 hypothetical protein YP_001344125.1 KEGG: mma:MM2099 hypothetical protein YP_001344126.1 PFAM: UDP-galactopyranose mutase; KEGG: msu:MS0661 UDP-galactopyranose mutase YP_001344127.1 PFAM: sugar transferase; KEGG: msu:MS0662 WcaJ protein YP_001344128.1 PFAM: acyltransferase 3; KEGG: ajs:Ajs_0557 acyltransferase 3 YP_001344129.1 PFAM: acyltransferase 3; KEGG: bte:BTH_II0715 hypothetical protein YP_001344130.1 KEGG: blo:BL1474 narrowly conserved hypothetical protein YP_001344131.1 TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: vfi:VF0166 dTDP-glucose 4,6-dehydratase YP_001344132.1 TIGRFAM: nucleotidyltransferase substrate binding protein, HI0074 family; PFAM: Nucleotidyltransferase substrate binding protein HI0074; KEGG: hit:NTHI0087 hypothetical protein YP_001344133.1 PFAM: DNA polymerase beta domain protein region; KEGG: hin:HI0073 nucleotidyltransferase YP_001344134.1 TIGRFAM: glucose-1-phosphate thymidylyltransferase; PFAM: Nucleotidyl transferase; KEGG: nmc:NMC0064 glucose-1-phosphate thymidylyltransferase YP_001344135.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: pin:Ping_3463 dTDP-4-dehydrorhamnose reductase YP_001344136.1 KEGG: smu:SMU.1206c hypothetical protein YP_001344137.1 TIGRFAM: dTDP-4-dehydrorhamnose 3,5-epimerase; PFAM: dTDP-4-dehydrorhamnose 35-epimerase related; KEGG: nme:NMB0081 dTDP-4-dehydrorhamnose 3,5-epimerase YP_001344138.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_001344139.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001344140.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001344141.1 PFAM: porin opacity type; KEGG: msu:MS1161 hypothetical protein YP_001344142.1 PFAM: protein of unknown function DUF335 SprT; SMART: protein of unknown function SprT; KEGG: hit:NTHI1341 SprT YP_001344143.1 PFAM: porin opacity type; KEGG: msu:MS1161 hypothetical protein YP_001344144.1 molecular chaperone YP_001344145.1 PFAM: 4'-phosphopantetheinyl transferase; KEGG: msu:MS1695 Sfp protein YP_001344146.1 PFAM: NUDIX hydrolase; KEGG: msu:MS1694 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_001344147.1 PFAM: metallophosphoesterase; Calcineurin phosphoesterase domain protein; KEGG: msu:MS1693 predicted phosphohydrolases YP_001344148.1 ATP-binding protein; required for proper cytochrome c maturation YP_001344149.1 TIGRFAM: heme exporter protein CcmB; PFAM: cytochrome c-type biogenesis protein CcmB; KEGG: msu:MS0602 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_001344150.1 TIGRFAM: heme exporter protein CcmC; PFAM: cytochrome c assembly protein; KEGG: msu:MS0603 ABC-type transport system involved in cytochrome c biogenesis, permease component YP_001344151.1 PFAM: Heme exporter protein D (CcmD); KEGG: msu:MS0604 heme exporter protein D YP_001344152.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001344153.1 TIGRFAM: cytochrome c-type biogenesis protein CcmF; PFAM: cytochrome c assembly protein; KEGG: pmu:PM0010 cytochrome C-type biogenesis YP_001344154.1 TIGRFAM: periplasmic protein thiol--disulphide oxidoreductase DsbE; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: hit:NTHI1259 thiol:disulfide interchange protein DsbE YP_001344155.1 PFAM: cytochrome C biogenesis protein; KEGG: hin:HI1096m cytochrome C-type biogenesis protein YP_001344156.1 KEGG: msu:MS0609 NrfG protein YP_001344157.1 KEGG: msu:MS0612 hypothetical protein YP_001344158.1 KEGG: msu:MS0613 hypothetical protein YP_001344159.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001344160.1 KEGG: msu:MS1114 hypothetical protein YP_001344161.1 PFAM: polysaccharide deacetylase; KEGG: msu:MS1113 predicted xylanase/chitin deacetylase YP_001344162.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein YP_001344164.1 PFAM: glycoside hydrolase family 20; KEGG: msu:MS1111 Chb protein YP_001344165.1 PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: msu:MS1730 sensory transduction histidine kinases YP_001344166.1 PFAM: inositol monophosphatase; KEGG: pmu:PM0315 putative myo-inositol-1(or 4)-monophosphatase YP_001344167.1 TIGRFAM: RNA methyltransferase, TrmH family, group 1; PFAM: tRNA/rRNA methyltransferase (SpoU); KEGG: msu:MS1728 rRNA methylase YP_001344168.1 TIGRFAM: putative transcriptional regulator, Rrf2 family; iron-sulfur cluster assembly transcription factor IscR; PFAM: protein of unknown function UPF0074; KEGG: msu:MS1727 hypothetical protein YP_001344169.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_001344170.1 TIGRFAM: FeS cluster assembly scaffold IscU; PFAM: nitrogen-fixing NifU domain protein; KEGG: msu:MS1724 NifU similarity involved in Fe-S cluster formation YP_001344171.1 TIGRFAM: iron-sulfur cluster assembly accessory protein; iron-sulfur cluster assembly protein IscA; PFAM: HesB/YadR/YfhF-family protein; KEGG: hso:HS_0283 HesB-family protein YP_001344172.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_001344173.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001344174.1 TIGRFAM: ferredoxin, 2Fe-2S type, ISC system; PFAM: ferredoxin; KEGG: hit:NTHI0492 ferredoxin, 2Fe-2S YP_001344175.1 PFAM: protein of unknown function DUF528; KEGG: yps:YPTB2853 hypothetical protein YP_001344176.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_001344177.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001344178.1 KEGG: msu:MS1580 hypothetical protein YP_001344179.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001344180.1 3'-5' exonuclease of DNA polymerase III YP_001344181.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001344182.1 Represses a number of genes involved in the response to DNA damage YP_001344183.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001344184.1 PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: pmu:PM0219 aerobic respiration control protein YP_001344185.1 PFAM: YCII-related; KEGG: msu:MS0735 hypothetical protein YP_001344186.1 PFAM: thioesterase superfamily protein; KEGG: msu:MS0736 acyl-CoA hydrolase YP_001344187.1 Involved in cell division; probably involved in intracellular septation YP_001344188.1 KEGG: hin:HI0825 hypothetical protein YP_001344189.1 TIGRFAM: DNA repair protein RecN; PFAM: SMC domain protein; KEGG: msu:MS0741 ATPases involved in DNA repair YP_001344190.1 catalyzes the phosphorylation of NAD to NADP YP_001344191.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001344192.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_001344193.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001344194.1 PFAM: Gluconate transporter; Citrate transporter; KEGG: pmu:PM1740 gluconate transport protein homolog YP_001344195.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_001344196.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_001344197.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_001344198.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001344199.1 PFAM: protein of unknown function DUF6 transmembrane; KEGG: hin:HI0687 hypothetical YP_001344200.1 PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: ajs:Ajs_3196 glutathione-dependent formaldehyde-activating, GFA YP_001344201.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001344202.1 KEGG: hso:HS_1672 cytochrome c-type protein YP_001344203.1 TIGRFAM: trimethylamine-N-oxide reductase TorA; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: hso:HS_1673 trimethylamine-N-oxide reductase precursor YP_001344204.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor YP_001344205.1 PFAM: periplasmic binding protein; KEGG: yps:YPTB1369 putative periplasmic iron/siderophore binding protein YP_001344206.1 PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: efa:EF0974 hypothetical protein YP_001344207.1 PFAM: periplasmic binding protein; KEGG: yps:YPTB1369 putative periplasmic iron/siderophore binding protein YP_001344208.1 PFAM: transport system permease protein; ABC-3 protein; KEGG: mba:Mbar_A0466 Fe(III) dicitrate ABC transporter, permease YP_001344209.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pac:PPA1778 Fe(III) dicitrate ABC transporter, ATP-binding protein YP_001344210.1 TIGRFAM: pseudoazurin; PFAM: blue (type 1) copper domain protein; KEGG: bba:Bd2567 pseudoazurin YP_001344211.1 KEGG: aba:Acid345_3870 hypothetical protein YP_001344212.1 TIGRFAM: putative methyltransferase; PFAM: methyltransferase putative; Methyltransferase type 11; Methyltransferase type 12; KEGG: hit:NTHI1815 hypothetical protein YP_001344213.1 TIGRFAM: SSS sodium solute transporter superfamily; sodium/proline symporter; PFAM: Na+ symporter; KEGG: msu:MS0777 Na+/proline, Na+/panthothenate symporters and related permeases YP_001344214.1 involved in the processing of the 5'end of 16S rRNA YP_001344215.1 PFAM: peptidase U62 modulator of DNA gyrase; KEGG: hso:HS_0276 modulator of DNA gyrase YP_001344216.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_001344217.1 TIGRFAM: PTS system, sucrose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: msu:MS0784 phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific YP_001344218.1 PFAM: protein of unknown function DUF208; KEGG: msu:MS1601 hypothetical protein YP_001344219.1 PFAM: Polyprenyl synthetase; KEGG: hit:NTHI1044 octaprenyl-diphosphate synthase YP_001344220.1 PFAM: ribosomal protein L21; KEGG: msu:MS1599 ribosomal protein L21 YP_001344221.1 involved in the peptidyltransferase reaction during translation YP_001344222.1 PFAM: protein of unknown function DUF6 transmembrane; KEGG: msu:MS1595 RhaT protein YP_001344223.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001344224.1 PFAM: protein of unknown function DUF496; KEGG: msu:MS1572 hypothetical protein YP_001344225.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001344226.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001344227.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001344228.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_001344229.1 PFAM: protein of unknown function DUF1239; KEGG: msu:MS1714 hypothetical protein YP_001344230.1 TIGRFAM: Cell envelope biogenesis YhbN; PFAM: OstA family protein; KEGG: msu:MS1715 hypothetical protein YP_001344231.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS1716 ABC-type (unclassified) transport system, ATPase component YP_001344232.1 TIGRFAM: PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; KEGG: msu:MS1717 phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) YP_001344233.1 PFAM: uncharacterised P-loop ATPase protein UPF0042; KEGG: msu:MS1718 predicted P-loop-containing kinase YP_001344234.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001344235.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001344236.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_001344237.1 TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase type I; KEGG: msu:MS0614 phosphomannose isomerase YP_001344238.1 KEGG: hso:HS_0606 hypothetical protein YP_001344239.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_001344240.1 TIGRFAM: PTS system, mannose/fructose/sorbose family, IIC subunit; PFAM: phosphotransferase system PTS sorbose-specific IIC subunit; KEGG: msu:MS0617 PTS system, mannose-specific IIC component YP_001344241.1 TIGRFAM: PTS system, mannose/fructose/sorbose family, IIB subunit; PTS system, mannose/fructose/sorbose family, IIA subunit; PFAM: PTS system fructose subfamily IIA component; PTS system sorbose subfamily IIB component; KEGG: msu:MS0618 phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB YP_001344242.1 PFAM: 17 kDa surface antigen; KEGG: msu:MS0801 hypothetical protein YP_001344243.1 PFAM: Xanthine/uracil/vitamin C permease; sulphate transporter; KEGG: pmu:PM0287 hypothetical HI0125 YP_001344244.1 KEGG: msu:MS0803 hypothetical protein YP_001344245.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001344246.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_001344247.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001344248.1 PFAM: NLP/P60 protein; KEGG: msu:MS1333 Spr protein YP_001344249.1 PFAM: peptidase S24 S26A and S26B; KEGG: msu:MS0831 hypothetical protein YP_001344250.1 involved in the import of serine and threonine coupled with the import of sodium YP_001344251.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_001344252.1 PFAM: band 7 protein; KEGG: msu:MS0834 HflC protein YP_001344253.1 PFAM: protein of unknown function DUF107; KEGG: msu:MS0835 hypothetical protein YP_001344254.1 PFAM: NAD(P)H dehydrogenase (quinone); KEGG: msu:MS0836 putative NADPH-quinone reductase (modulator of drug activity B) YP_001344255.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001344256.1 PFAM: permease YjgP/YjgQ family protein; KEGG: msu:MS1549 predicted permeases YP_001344257.1 PFAM: permease YjgP/YjgQ family protein; KEGG: msu:MS1548 predicted permeases YP_001344258.1 KEGG: msu:MS0759 hypothetical protein YP_001344259.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001344260.1 PFAM: conserved hypothetical protein 1620; KEGG: msu:MS0761 hypothetical protein YP_001344261.1 PFAM: sigma-54 factor interaction domain-containing protein; SMART: AAA ATPase; KEGG: msu:MS0762 transcriptional regulator of aromatic amino acids metabolism YP_001344262.1 PFAM: ferric-uptake regulator; KEGG: msu:MS0859 Fur protein YP_001344263.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001344264.1 KEGG: msu:MS0861 hypothetical protein YP_001344265.1 PFAM: alpha/beta hydrolase fold; PGAP1 family protein; KEGG: hso:HS_1209 esterase/lipase YP_001344266.1 negative modulator of the initiation of chromosome replication YP_001344267.1 TIGRFAM: O-succinylbenzoate-CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: msu:MS0864 acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II YP_001344268.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_001344269.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001344270.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_001344271.1 PFAM: protein of unknown function DUF81; KEGG: msu:MS0868 predicted permeases YP_001344272.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_001344273.1 TIGRFAM: adenine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: msu:MS0870 adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins YP_001344274.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001344275.1 PFAM: CAT RNA-binding domain protein; PRD domain protein; KEGG: lin:lin2530 similar to transcription antiterminator YP_001344276.1 PFAM: glycoside hydrolase family 1; KEGG: lwe:lwe0230 glycosyl hydrolase, family 1 YP_001344277.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: ssa:SSA_0420 hydrolase, HAD superfamily, putative YP_001344278.1 TIGRFAM: PTS system, glucose subfamily, IIA subunit; PTS system, beta-glucoside-specific IIABC subunit; PTS system, glucose-like IIB subunint; PFAM: sugar-specific permease EIIA 1 domain; phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: bld:BLi04200 close homolog to BglP PTS enzyme IIBCA component; RBL02058 YP_001344279.1 KEGG: pmu:PM0367 hypothetical HI1626 YP_001344280.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001344281.1 TIGRFAM: nitrite reductase, copper-containing; KEGG: msu:MS0876 SufI protein YP_001344282.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001344283.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001344284.1 PFAM: peptidase U32; KEGG: msu:MS0786 collagenase and related proteases YP_001344285.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001344286.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001344287.1 KEGG: pmu:PM0814 hypothetical E.coli YP_001344288.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_001344289.1 TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; KEGG: msu:MS1519 GTPases YP_001344290.1 TIGRFAM: RNA chaperone Hfq; PFAM: Like-Sm ribonucleoprotein core; KEGG: msu:MS1518 uncharacterized ACR, host factor I protein YP_001344291.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001344292.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001344293.1 PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: msu:MS1515 N-acetylmuramoyl-L-alanine amidase YP_001344294.1 PFAM: protein of unknown function UPF0079; KEGG: msu:MS1514 predicted ATPase or kinase YP_001344295.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001344296.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_001344297.1 TIGRFAM: phosphocarrier, HPr family; PFAM: phosphocarrier HPr protein; KEGG: msu:MS1510 phosphotransferase system, HPr-related proteins YP_001344298.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_001344299.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_001344300.1 PFAM: conserved hypothetical protein 103; KEGG: hso:HS_1309 hypothetical protein YP_001344301.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001344302.1 KEGG: msu:MS0837 TorD protein YP_001344303.1 TIGRFAM: hypothetical membrane protein; integral membrane protein, YccS/YhfK family; PFAM: protein of unknown function DUF893 YccS/YhfK; KEGG: pmu:PM0392 hypothetical HI1680 YP_001344304.1 PFAM: protein of unknown function DUF307; KEGG: msu:MS0838 hypothetical protein YP_001344305.1 KEGG: msu:MS0844 hypothetical protein YP_001344306.1 catalyzes the hydrolysis of acylphosphate YP_001344307.1 PFAM: DsrC family protein; KEGG: msu:MS0846 sulfite reductase, gamma subunit YP_001344308.1 PFAM: protein of unknown function UPF0005; KEGG: msu:MS0847 integral membrane protein, interacts with FtsH YP_001344309.1 TIGRFAM: filamentous haemagglutinin family outer membrane protein; adhesin HecA family; PFAM: Haemagluttinin repeat-containing protein; filamentous haemagglutinin domain protein; KEGG: nme:NMB1768 hemagglutinin/hemolysin-related protein YP_001344311.1 KEGG: msu:MS1167 FhaB protein YP_001344312.1 PFAM: protein of unknown function DUF1436; KEGG: pmu:PM0496 unknown YP_001344313.1 KEGG: msu:MS1167 FhaB protein YP_001344314.1 PFAM: FeoA family protein; KEGG: msu:MS1159 hypothetical protein YP_001344315.1 TIGRFAM: ferrous iron transport protein B; small GTP-binding protein; PFAM: GTP-binding protein HSR1-related; Ferrous iron transport protein B domain protein; Ferrous iron transport B domain protein; nucleoside recognition domain protein; KEGG: msu:MS1158 ferrous ion uptake system protein FeoB (predicted GTPase) YP_001344316.1 KEGG: msu:MS1156 hypothetical protein YP_001344317.1 Regulatory factor involved in maltose metabolism YP_001344318.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: vpa:VPA1435 putative iron(III) compound receptor YP_001344319.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_001344320.1 PFAM: periplasmic binding protein; KEGG: msu:MS1202 FecB protein YP_001344321.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS1201 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components YP_001344322.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_001344323.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_001344324.1 catalyzes branch migration in Holliday junction intermediates YP_001344325.1 KEGG: msu:MS1736 guanosine polyphosphate pyrophosphohydrolases/synthetases; TIGRFAM: RelA/SpoT family protein; PFAM: TGS domain protein; metal-dependent phosphohydrolase HD sub domain; RelA/SpoT domain protein; SMART: metal-dependent phosphohydrolase HD region YP_001344326.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001344327.1 Essential for recycling GMP and indirectly, cGMP YP_001344328.1 TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: msu:MS1739 glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase YP_001344329.1 TIGRFAM: penicillin-binding protein 1B; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; KEGG: msu:MS1312 MrcA protein YP_001344330.1 PFAM: uncharacterised conserved protein UCP006287; KEGG: msu:MS1308 hypothetical protein YP_001344331.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_001344332.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001344333.1 KEGG: msu:MS1305 UTPGlnB (protein PII) uridylyltransferase; TIGRFAM: protein-P-II uridylyltransferase; PFAM: amino acid-binding ACT domain protein; DNA polymerase beta domain protein region; metal-dependent phosphohydrolase HD sub domain; GlnD PII-uridylyltransferase; SMART: metal-dependent phosphohydrolase HD region YP_001344334.1 TIGRFAM: Cu(I)-responsive transcriptional regulator; PFAM: regulatory protein MerR; Transcription regulator MerR DNA binding; KEGG: msu:MS0886 SoxR protein YP_001344335.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein; KEGG: plu:plu3824 copper-transporting P-type ATPase YP_001344336.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_001344337.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001344338.1 PFAM: histone family protein nucleoid-structuring protein H-NS; KEGG: hit:NTHI1464 DNA-binding protein H-NS homolog YP_001344339.1 PFAM: Na+ antiporter NhaC; KEGG: msu:MS1321 NhaC protein YP_001344340.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate YP_001344341.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001344342.1 PFAM: sulfatase; KEGG: hdu:HD0371 hypothetical protein YP_001344343.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_001344344.1 PFAM: protein of unknown function UPF0227; KEGG: pmu:PM0825 hypothetical E.coli YP_001344345.1 PFAM: FAD linked oxidase domain protein; KEGG: msu:MS1221 FAD/FMN-containing dehydrogenases YP_001344346.1 PFAM: OmpA domain protein transmembrane region-containing protein; OmpA/MotB domain protein; KEGG: msu:MS1218 outer membrane protein and related peptidoglycan-associated (lipo)proteins YP_001344347.1 PFAM: LemA family protein; KEGG: msu:MS1217 uncharacterized ACR YP_001344348.1 PFAM: protein of unknown function DUF477; KEGG: msu:MS1216 hypothetical protein YP_001344349.1 PFAM: protein of unknown function DUF477; KEGG: msu:MS1215 beta-propeller domains of methanol dehydrogenase type YP_001344350.1 TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin; KEGG: msu:MS1212 glutaredoxin-related proteins YP_001344351.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001344352.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001344353.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001344354.1 PFAM: SirA family protein; KEGG: msu:MS1561 SirA protein YP_001344355.1 KEGG: aha:AHA_0745 hypothetical protein YP_001344356.1 PFAM: Hemerythrin HHE cation binding domain protein; KEGG: msu:MS1560 hypothetical protein YP_001344357.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001344358.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001344359.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001344360.1 PFAM: GCN5-related N-acetyltransferase; KEGG: sak:SAK_0496 acetyltransferase, GNAT family YP_001344361.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001344362.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_001344363.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_001344364.1 TIGRFAM: anaerobic c4-dicarboxylate antiporter, DcuC family; PFAM: C4-dicarboxylate anaerobic carrier; Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: msu:MS1553 DcuC protein YP_001344365.1 TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: msu:MS1552 AbgB protein YP_001344366.1 PFAM: aldehyde dehydrogenase; KEGG: msu:MS1551 PutA protein YP_001344367.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_001344368.1 PFAM: short-chain dehydrogenase/reductase SDR; KEGG: hdu:HD1266 enoyl-[acyl-carrier-protein] reductase [NADH] YP_001344369.1 PFAM: protein of unknown function DUF34; KEGG: msu:MS1464 hypothetical protein YP_001344370.1 TIGRFAM: HflC protein; PFAM: band 7 protein; KEGG: pmu:PM0118 HflC protein YP_001344371.1 TIGRFAM: HflK protein; PFAM: band 7 protein; KEGG: hit:NTHI0239 HflK YP_001344372.1 KEGG: msu:MS1616 hypothetical protein YP_001344373.1 KEGG: pmu:PM0931 unknown YP_001344374.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_001344375.1 TIGRFAM: UDP-N-acetylmuramate; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: msu:MS1614 UDP-N-acetylmuramate-alanine ligase YP_001344376.1 PFAM: Polynucleotide adenylyltransferase region; KEGG: msu:MS2312 tRNA nucleotidyltransferase (CCA-adding enzyme) YP_001344377.1 PFAM: SH3 type 3 domain protein; SMART: SH3 domain protein; KEGG: msu:MS2311 SH3 domain protein YP_001344378.1 PFAM: phosphate transporter; KEGG: msu:MS2310 phosphate/sulphate permeases YP_001344379.1 PFAM: protein of unknown function DUF47; KEGG: pmu:PM0250 hypothetical HI1603 YP_001344380.1 PFAM: adenylate cyclase; KEGG: msu:MS2307 hypothetical protein YP_001344381.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001344382.1 PFAM: Mammalian cell entry related domain protein; KEGG: msu:MS0817 PqiB protein YP_001344383.1 TIGRFAM: integral membrane protein, PqiA family; PFAM: Paraquat-inducible protein A; KEGG: msu:MS0819 PqiA protein YP_001344384.1 affects solute and DNA transport through an unknown mechanism YP_001344385.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_001344386.1 KEGG: msu:MS0822 hypothetical protein YP_001344387.1 PFAM: protein of unknown function DUF882; Peptidase M15A; KEGG: pmu:PM0271 hypothetical E.coli YP_001344388.1 PFAM: beta-lactamase domain protein; KEGG: pmu:PM0272 hypothetical HI1663 YP_001344389.1 KEGG: msu:MS1292 hypothetical protein YP_001344390.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001344391.1 TIGRFAM: Na+/Ca+ antiporter, CaCA family; PFAM: sodium/calcium exchanger membrane region; KEGG: msu:MS1372 Ca2+/Na+ antiporter YP_001344392.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001344393.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001344394.1 KEGG: msu:MS1332 hypothetical protein YP_001344395.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001344396.1 TIGRFAM: acyl-CoA thioesterase II; PFAM: acyl-CoA thioesterase; KEGG: msu:MS0948 acyl-CoA thioesterase YP_001344397.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001344398.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001344399.1 KEGG: msu:MS1456 hypothetical protein YP_001344400.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_001344401.1 PFAM: cell divisionFtsK/SpoIIIE; KEGG: msu:MS1454 DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family YP_001344402.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_001344403.1 PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: hit:NTHI1458 predicted ATPase related to the helicase subunit of the holliday junction resolvase YP_001344404.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_001344405.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001344406.1 PFAM: Auxin Efflux Carrier; KEGG: hso:HS_0732 conserved hypothetical protein YP_001344407.1 PFAM: Aldose 1-epimerase; KEGG: msu:MS1362 hypothetical protein YP_001344408.1 SMART: helicase c2; KEGG: msu:MS1361 rad3-related DNA helicases YP_001344409.1 PFAM: peptidase M22 glycoprotease; KEGG: msu:MS1360 hypothetical protein YP_001344410.1 TIGRFAM: outer membrane lipoprotein, Slp family; PFAM: outer membrane lipoprotein Slp; KEGG: msu:MS1359 starvation-inducible outer membrane lipoprotein YP_001344411.1 Activates fatty acids by binding to coenzyme A YP_001344412.1 TIGRFAM: ribonuclease D; PFAM: HRDC domain protein; 3'-5' exonuclease; KEGG: msu:MS1357 ribonuclease D YP_001344413.1 PFAM: protein of unknown function DUF991; KEGG: hit:NTHI1471 hypothetical protein YP_001344414.1 KEGG: msu:MS1327 hypothetical protein YP_001344415.1 PFAM: 17 kDa surface antigen; KEGG: msu:MS1326 outer membrane lipoprotein YP_001344416.1 PFAM: extracellular solute-binding protein family 5; KEGG: pmu:PM0678 oligopeptide-binding protein homolog, periplasmic, putative YP_001344417.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001344418.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001344419.1 PFAM: protein of unknown function DUF1439; KEGG: msu:MS1449 hypothetical protein YP_001344420.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001344421.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001344422.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001344423.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001344424.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001344425.1 KEGG: dde:Dde_0264 hypothetical protein YP_001344426.1 TIGRFAM: tRNA(Ile)-lysidine synthetase; PFAM: PP-loop domain protein; Protein of unkown function DUF1946 PP-loop ATpase; KEGG: msu:MS0804 predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_001344427.1 TIGRFAM: pyridoxal kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: hso:HS_0933 pyridoxine kinase YP_001344428.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001344429.1 PFAM: Domain of unknown function DUF1919; KEGG: msu:MS0770 hypothetical protein YP_001344430.1 TIGRFAM: ABC transporter, periplasmic binding protein, thiB subfamily; thiamine ABC transporter, periplasmic binding protein; KEGG: msu:MS1526 ABC-type iron/thiamine transport systems, periplasmic component YP_001344431.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_001344432.1 TIGRFAM: ABC transporter, ATPase subunit, ThiQ subfamily; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS1524 ABC-type sugar/spermidine/putrescine/iron/thiamine transport systems, ATPase component YP_001344433.1 KEGG: msu:MS1523 biotin synthase and related enzymes; TIGRFAM: biotin synthase; PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; SMART: Elongator protein 3/MiaB/NifB YP_001344434.1 PFAM: protein of unknown function DUF488; KEGG: msu:MS1522 hypothetical protein YP_001344435.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: msu:MS1521 peroxiredoxin YP_001344436.1 catalyzes the formation of L-homocysteine from cystathionine YP_001344437.1 PFAM: iron-containing alcohol dehydrogenase; KEGG: msu:MS0883 hypothetical protein YP_001344438.1 PFAM: porin Gram-negative type; KEGG: msu:MS1337 OmpC protein YP_001344439.1 TIGRFAM: addiction module antidote protein, HigA family; KEGG: neu:NE1304 bacterial regulatory protein, LacI family:helix-turn-helix motif YP_001344440.1 TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: msu:MS1304 TolC protein YP_001344441.1 PFAM: ABC-2 type transporter; KEGG: msu:MS1303 ABC-type multidrug transport system, permease component YP_001344442.1 PFAM: ABC transporter related; ABC-2 type transporter; SMART: AAA ATPase; KEGG: msu:MS1302 ABC-type multidrug transport system, ATPase component YP_001344443.1 PFAM: secretion protein HlyD family protein; KEGG: msu:MS1301 membrane-fusion protein YP_001344444.1 PFAM: regulatory protein TetR; KEGG: msu:MS1300 AcrR protein YP_001344445.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_001344446.1 TIGRFAM: Dyp-type peroxidase family; PFAM: Dyp-type peroxidase; KEGG: msu:MS0947 predicted iron-dependent peroxidase YP_001344447.1 involved in de novo purine biosynthesis YP_001344448.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001344449.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: msu:MS2134 LysR protein YP_001344450.1 PFAM: Auxin Efflux Carrier; KEGG: msu:MS1440 predicted permeases YP_001344451.1 PFAM: protein of unknown function DUF441; KEGG: hso:HS_0993 possible permease YP_001344452.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_001344453.1 PFAM: glycosyl transferase family 51; KEGG: rxy:Rxyl_1310 penicillin-binding protein 1A YP_001344454.1 TIGRFAM: carbohydrate kinase, thermoresistant glucokinase family; PFAM: shikimate kinase; KEGG: msu:MS0957 gluconate kinase YP_001344455.1 NAD-binding YP_001344456.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate YP_001344457.1 TIGRFAM: gluconate transporter; PFAM: Gluconate transporter; Citrate transporter; KEGG: hso:HS_0378 gluconate permease YP_001344458.1 PFAM: YadA domain protein; Haemagluttinin domain protein; Hep_Hag repeat-containing protein; KEGG: msu:MS0748 hypothetical protein YP_001344459.1 PFAM: Bile acid:sodium symporter; KEGG: msu:MS0879 predicted Na+-dependent transporter YP_001344460.1 TIGRFAM: protease Do; PFAM: peptidase S1 and S6 chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: msu:MS0993 trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain YP_001344461.1 TIGRFAM: gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase; KEGG: aav:Aave_1114 gamma-glutamyltransferase YP_001344462.1 KEGG: msu:MS2120 hypothetical protein YP_001344463.1 PFAM: TRAP dicarboxylate transporter- DctP subunit; KEGG: oih:OB2702 C4-dicarboxylate transport system C4-dicarboxylate-binding protein YP_001344464.1 PFAM: Tripartite ATP-independent periplasmic transporter DctQ component; KEGG: oih:OB2701 hypothetical protein YP_001344465.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: oih:OB2700 C4-dicarboxylate transport system permease large protein YP_001344466.1 PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: reh:H16_B1806 transcriptional regulator, LacI-family YP_001344467.1 PFAM: PfkB domain protein; KEGG: bpm:BURPS1710b_2288 2-dehydro-3-deoxygluconokinase YP_001344468.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: eca:ECA0078 2-hydroxyacid dehydrogenase YP_001344469.1 PFAM: protein of unknown function DUF711; KEGG: msu:MS1380 hypothetical protein YP_001344470.1 ACT domain-containing protein YP_001344471.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001344472.1 PFAM: ABC transporter related; SbmABacA family protein; ABC transporter domain protein; SMART: AAA ATPase; KEGG: msu:MS1316 SbmA protein YP_001344473.1 TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: msu:MS1315 outer membrane receptor proteins, mostly Fe transport YP_001344474.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_001344475.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001344476.1 KEGG: cff:CFF8240_1390 hypothetical protein YP_001344477.1 PFAM: GtrA family protein; KEGG: cbu:CBU_1853 GtrA family protein, putative YP_001344478.1 PFAM: transport-associated; SMART: Transport-associated and nodulation region; KEGG: msu:MS1291 OsmY protein YP_001344479.1 PFAM: Xanthine/uracil/vitamin C permease; KEGG: msu:MS1018 permeases YP_001344480.1 PFAM: DsrE family protein; KEGG: pmu:PM0515 putative uncharacterized protein involved in oxidation of intracellular sulfur YP_001344481.1 TIGRFAM: exodeoxyribonuclease V, beta subunit; PFAM: UvrD/REP helicase; KEGG: msu:MS1099 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) YP_001344482.1 TIGRFAM: exodeoxyribonuclease V, alpha subunit; KEGG: msu:MS1098 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member YP_001344483.1 PFAM: protein of unknown function DUF808; KEGG: msu:MS0943 hypothetical protein YP_001344484.1 PFAM: protein of unknown function DUF181; KEGG: msu:MS0944 hypothetical protein YP_001344485.1 PFAM: Methyltransferase type 11; KEGG: pmu:PM0686 hypothetical E.coli YP_001344486.1 PFAM: beta-lactamase domain protein; KEGG: msu:MS0946 Zn-dependent hydrolases, including glyoxylases YP_001344487.1 catalyzes the formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_001344488.1 PFAM: permease for cytosine/purines uracil thiamine allantoin; KEGG: pmu:PM0564 cytosine permease/transport YP_001344489.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_001344490.1 PFAM: Methionine synthase vitamin-B12 independent; KEGG: msu:MS0941 MetE protein YP_001344491.1 PFAM: OmpW family protein; KEGG: msu:MS0740 outer membrane protein W YP_001344492.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_001344493.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_001344494.1 TIGRFAM: citrate lyase, beta subunit; PFAM: HpcH/HpaI aldolase; KEGG: hdu:HD1242 citrate lyase beta chain YP_001344495.1 TIGRFAM: citrate lyase, alpha subunit; PFAM: Citrate lyase alpha subunit; KEGG: hin:HI0022 citrate lyase alpha chain YP_001344496.1 TIGRFAM: regulator of ribonuclease activity A; PFAM: Dimethylmenaquinone methyltransferase; KEGG: eba:ebA4476 demethylmenaquinone methyltransferase YP_001344497.1 PFAM: triphosphoribosyl-dephospho-CoA protein; Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; KEGG: hit:NTHI0028 CitXG YP_001344498.1 PFAM: carbonic anhydrase; KEGG: msu:MS1065 carbonic anhydrase YP_001344499.1 PFAM: conserved hypothetical protein 730; KEGG: msu:MS1068 predicted Rossmann fold nucleotide-binding protein YP_001344500.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001344501.1 KEGG: msu:MS1070 hypothetical protein YP_001344502.1 PFAM: protein of unknown function DUF446; KEGG: msu:MS1071 hypothetical protein YP_001344503.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_001344505.1 KEGG: stt:t1914 putative methyltransferase YP_001344506.1 PFAM: protein of unknown function DUF1071; KEGG: lla:L42302 topoisomerase YP_001344507.1 KEGG: sit:TM1040_1688 hypothetical protein YP_001344508.1 TIGRFAM: Addiction module killer protein HI1419; PFAM: protein of unknown function DUF891; KEGG: dvl:Dvul_1444 protein of unknown function DUF891 YP_001344509.1 TIGRFAM: Addiction module antidote protein HI1420; KEGG: ppu:PP_0829 hypothetical protein YP_001344510.1 TIGRFAM: addiction module antidote protein, HigA family; PFAM: helix-turn-helix domain protein; protein of unknown function DUF955; KEGG: rru:Rru_A0006 plasmid maintenance system antidote protein YP_001344511.1 KEGG: sfu:Sfum_1442 killer suppression protein HigA, putative YP_001344512.1 PFAM: helix-turn-helix domain protein; peptidase S24 S26A and S26B; KEGG: spt:SPA2414 transcriptional activator-regulatory protein YP_001344513.1 KEGG: hit:NTHI1516 hypothetical protein YP_001344514.1 KEGG: hit:NTHI1722 hypothetical protein YP_001344515.1 KEGG: hso:HS_1403 hypothetical protein YP_001344516.1 PFAM: replication P family protein; KEGG: ecv:APECO1_234 putative replication protein P of bacteriophage YP_001344517.1 PFAM: DNA N-6-adenine-methyltransferase; KEGG: sgl:SG0744 phage DNA methyltransferase YP_001344518.1 PFAM: protein of unknown function DUF1367; KEGG: yps:YPTB1800 conserved putative phage protein YP_001344519.1 PFAM: protein of unknown function DUF1364; KEGG: spt:SPA2402 hypothetical protein YP_001344520.1 PFAM: endodeoxyribonuclease RusA; KEGG: sec:SC0344 Rus YP_001344521.1 KEGG: hso:HS_1393 hypothetical protein YP_001344522.1 KEGG: vvy:VVA0152 hypothetical protein YP_001344523.1 KEGG: eci:UTI89_C2637 antirepressor protein YP_001344525.1 TIGRFAM: phage holin, lambda family; PFAM: Holin phage lambda; KEGG: sec:SC2615 Gifsy-1 prophage protein YP_001344526.1 KEGG: gsu:GSU3176 LysM domain protein YP_001344527.1 KEGG: hit:NTHI1738 hypothetical protein YP_001344529.1 PFAM: HNH endonuclease; SMART: HNH nuclease; KEGG: ecv:APECO1_1027 HnhC YP_001344530.1 TIGRFAM: phage terminase, small subunit, putative, P27 family; PFAM: phage terminase small subunit putative P27; KEGG: bpm:BURPS1710b_1678 phage terminase, small subunit, putative, P27 family YP_001344531.1 PFAM: phage Terminase; KEGG: ecv:APECO1_3890 bacteriophage V large terminase subunit YP_001344532.1 KEGG: rso:RSc1681 hypothetical protein YP_001344533.1 TIGRFAM: phage portal protein, HK97 family; PFAM: phage portal protein; KEGG: ecv:APECO1_1024 putative phage portal protein YP_001344534.1 TIGRFAM: phage prohead protease, HK97 family; PFAM: peptidase U35 phage prohead HK97; KEGG: ecv:APECO1_1023 putative phage capsid protease YP_001344535.1 TIGRFAM: phage major capsid protein, HK97 family; PFAM: phage major capsid protein HK97; KEGG: ecv:APECO1_1022 putative phage capsid protein YP_001344536.1 TIGRFAM: uncharacterized phage protein (possible DNA packaging); KEGG: ecv:APECO1_1021 hypothetical protein YP_001344537.1 TIGRFAM: phage head-tail adaptor, putative; PFAM: phage head-tail adaptor putative; KEGG: dvl:Dvul_0865 phage head-tail adaptor, putative YP_001344538.1 TIGRFAM: phage protein, HK97 gp10 family; PFAM: TP901-1 ORF40 family protein; KEGG: ecs:ECs1547 hypothetical protein YP_001344544.1 TIGRFAM: phage tape measure protein; KEGG: hdu:HD1569 putative tail length tape measure protein YP_001344545.1 PFAM: phage minor tail family protein; KEGG: sec:SC0995 Gifsy-2 prophage probable minor tail protein YP_001344546.1 PFAM: phage minor tail protein L; KEGG: nmc:NMC0867 putative phage-related protein YP_001344547.1 PFAM: NLP/P60 protein; KEGG: stm:STM1046 probable tail assembly protein YP_001344548.1 PFAM: bacteriophage lambda tail assembly I; KEGG: stm:STM0923 putative phage tail assembly protein YP_001344549.1 PFAM: Fibronectin type III domain protein; Protein of unknown function DUF1983; KEGG: nmc:NMC0870 Neisseria meningitidis phage 2120.; ORF 4 YP_001344553.1 PFAM: phage integrase family protein; KEGG: hso:HS_1337 integrase YP_001344554.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_001344555.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: msu:MS0842 predicted hydrolases of the HAD superfamily YP_001344556.1 required for the formation of active formate dehydrogenase YP_001344557.1 TIGRFAM: formate dehydrogenase, gamma subunit; KEGG: msu:MS1028 cytochrome b subunit of formate dehydrogenase YP_001344558.1 TIGRFAM: formate dehydrogenase, beta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; Formate dehydrogenase transmembrane domain protein; KEGG: msu:MS1029 HybA protein YP_001344559.1 TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: msu:MS0891 anaerobic dehydrogenases, typically selenocysteine-containing YP_001344560.1 PFAM: molybdopterin oxidoreductase Fe4S4 region; KEGG: msu:MS0892 anaerobic dehydrogenases, typically selenocysteine-containing YP_001344561.1 TIGRFAM: formate dehydrogenase family accessory protein FdhD; PFAM: formate dehydrogenase subunit FdhD; KEGG: msu:MS0893 uncharacterized protein required for formate dehydrogenase activity YP_001344562.1 PFAM: extracellular solute-binding protein family 1; KEGG: msu:MS1370 TbpA protein YP_001344563.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_001344564.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_001344565.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001344566.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_001344567.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001344568.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: hso:HS_0848 ABC-type multidrug transport system, ATP-binding protein YP_001344569.1 PFAM: ABC-2 type transporter; KEGG: msu:MS1067 ABC-type multidrug transport system, permease component YP_001344570.1 SohB; periplasmic protein; member of the peptidase S49 family YP_001344571.1 PFAM: OmpA/MotB domain protein; SmpA/OmlA domain protein; KEGG: pmu:PM0586 lipoprotein plp4 YP_001344572.1 involved in hydrogen uptake YP_001344573.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2 YP_001344574.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits YP_001344575.1 involved in hydrogen uptake YP_001344576.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC) YP_001344577.1 KEGG: msu:MS2359 hypothetical protein YP_001344578.1 TIGRFAM: hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); KEGG: msu:MS2358 hydrogenase maturation factor YP_001344579.1 TIGRFAM: CRISPR-associated helicase Cas3; PFAM: helicase domain protein; KEGG: rfr:Rfer_3901 CRISPR-associated helicase Cas3 YP_001344580.1 TIGRFAM: CRISPR-associated protein Cas5 family; CRISPR-associated protein Cas5; KEGG: eba:ebA3290 hypothetical protein YP_001344581.1 TIGRFAM: CRISPR-associated protein, Csd1 family; KEGG: rfr:Rfer_3903 CRISPR-associated protein, CT1133 YP_001344582.1 TIGRFAM: CRISPR-associated protein, CT1132 family; CRISPR-associated protein, Csd2 family; PFAM: CRISPR-associated protein TM1801; KEGG: eba:ebA3286 hypothetical protein YP_001344583.1 TIGRFAM: CRISPR-associated protein Cas4; KEGG: msu:MS0985 RecB family exonuclease YP_001344584.1 PFAM: Carboxymuconolactone decarboxylase; KEGG: lla:L178933 hypothetical protein YP_001344585.1 PFAM: helix-turn-helix HxlR type; KEGG: bcl:ABC3681 transcriptional regulator YP_001344586.1 KEGG: msu:MS0982 hypothetical protein YP_001344587.1 TIGRFAM: CRISPR-associated protein Cas1; PFAM: protein of unknown function DUF48; KEGG: msu:MS0981 hypothetical protein YP_001344588.1 TIGRFAM: CRISPR-associated protein Cas2; PFAM: protein of unknown function DUF196; KEGG: msu:MS0980 hypothetical protein YP_001344589.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001344590.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001344591.1 PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: msu:MS1298 hypothetical protein YP_001344592.1 PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: bld:BLi02779 hypothetical protein YP_001344593.1 PFAM: Endoribonuclease L-PSP; KEGG: bld:BLi02776 hypothetical protein YP_001344594.1 PFAM: YheO domain protein; KEGG: bld:BLi02781 DctR YP_001344595.1 PFAM: ATPase; KEGG: msu:MS2113 uncharacterized ATPases of the AAA superfamily YP_001344596.1 PFAM: Rhodanese domain protein; KEGG: nma:NMA0994 putative periplasmic protein YP_001344597.1 PFAM: B3/4 domain protein; KEGG: lac:LBA0250 hypothetical protein YP_001344598.1 PFAM: Citrate transporter; KEGG: bha:BH0745 magnesium citrate secondary transporter YP_001344599.1 PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: msu:MS2163 FabG protein YP_001344600.1 PFAM: NAD(P)H dehydrogenase (quinone); KEGG: msu:MS2162 MdaB protein YP_001344601.1 PFAM: aldo/keto reductase; KEGG: mpe:MYPE4720 oxidoreductase-aldo/keto reductase family YP_001344603.1 PFAM: Carboxymuconolactone decarboxylase; Cupin 2 conserved barrel domain protein; KEGG: msu:MS2158 hypothetical protein YP_001344604.1 KEGG: msu:MS2255 hypothetical protein YP_001344605.1 PFAM: DoxX family protein; KEGG: msu:MS2138 hypothetical protein YP_001344606.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: msu:MS1210 LysR protein YP_001344607.1 PFAM: regulatory protein MerR; KEGG: efa:EF2225 transcriptional regulator, MerR family YP_001344608.1 PFAM: multi antimicrobial extrusion protein MatE; KEGG: bha:BH4045 hypothetical protein YP_001344609.1 PFAM: helix-turn-helix domain protein; KEGG: vfi:VF1469 transcriptional regulator, MerR family YP_001344610.1 PFAM: HipA domain protein; KEGG: lpp:lpp0064 HipA protein, DNA binding regulator YP_001344611.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: bur:Bcep18194_B1969 transcriptional regulator, LysR family YP_001344612.1 PFAM: major facilitator superfamily MFS_1; KEGG: wsu:WS1952 transmembrane transport protein-permease YP_001344613.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: ppu:PP_0698 transcriptional regulator, LysR family YP_001344614.1 PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: rme:Rmet_5915 lysine exporter protein (LysE/YggA) YP_001344615.1 SMART: regulatory protein ArsR; KEGG: lpn:lpg2723 transcriptional regulator YP_001344616.1 PFAM: DSBA oxidoreductase; KEGG: msu:MS2007 FrnE protein YP_001344617.1 PFAM: phospholipase/Carboxylesterase; KEGG: mpt:Mpe_A0054 carboxylesterase YP_001344618.1 PFAM: beta-lactamase domain protein; KEGG: reh:H16_B0067 metal-dependent hydrolase of the beta-lactamase superfamily YP_001344619.1 PFAM: protein of unknown function DUF1228; major facilitator superfamily MFS_1; KEGG: pfo:Pfl_1953 hypothetical protein YP_001344620.1 PFAM: Alpha/beta hydrolase fold-3 domain protein; KEGG: msu:MS2161 Aes protein YP_001344621.1 KEGG: msu:MS1484 hypothetical protein YP_001344622.1 PFAM: aminoglycoside phosphotransferase; fructosamine kinase; KEGG: msu:MS1051 hypothetical protein YP_001344623.1 cofactor involved in the reduction of disulfides YP_001344624.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001344625.1 PFAM: protein of unknown function DUF218; KEGG: msu:MS0908 hypothetical protein YP_001344626.1 PFAM: polysaccharide pyruvyl transferase; KEGG: msu:MS0907 hypothetical protein YP_001344627.1 KEGG: msu:MS0906 hypothetical protein YP_001344628.1 PFAM: glycosyl transferase family 25; KEGG: msu:MS0905 glycosyltransferase involved in LPS biosynthesis YP_001344629.1 KEGG: msu:MS0904 hypothetical protein YP_001344630.1 PFAM: glycosyl transferase family 2; KEGG: msu:MS0903 WcaA protein YP_001344631.1 PFAM: glycosyl transferase family 2; KEGG: msu:MS0902 WcaA protein YP_001344632.1 TIGRFAM: lytic murein transglycosylase; KEGG: msu:MS0901 MltB protein YP_001344633.1 PFAM: extracellular solute-binding protein family 3; KEGG: msu:MS0900 ArtI protein YP_001344634.1 TIGRFAM: carbohydrate kinase, YjeF related protein; PFAM: protein of unknown function UPF0031; KEGG: ssp:SSP0007 hypothetical protein YP_001344635.1 involved in methylation of ribosomal protein L3 YP_001344636.1 PFAM: Smr protein/MutS2; KEGG: msu:MS1264 hypothetical protein YP_001344637.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001344638.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_001344639.1 TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: msu:MS1131 TolC protein YP_001344640.1 PFAM: ABC transporter related; protein of unknown function DUF214; SMART: AAA ATPase; KEGG: msu:MS1129 ABC-type transport systems, involved in lipoprotein release, permease components YP_001344641.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: msu:MS1128 membrane-fusion protein YP_001344642.1 PFAM: cell wall hydrolase/autolysin; KEGG: bam:Bamb_4275 cell wall hydrolase/autolysin YP_001344643.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001344644.1 KEGG: msu:MS1126 hypothetical protein YP_001344645.1 PFAM: protein of unknown function UPF0153; KEGG: msu:MS1125 hypothetical protein YP_001344646.1 TIGRFAM: 4-alpha-glucanotransferase; PFAM: glycoside hydrolase family 77; KEGG: hso:HS_0890 4-alpha-glucanotransferase YP_001344647.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001344648.1 TIGRFAM: glycogen debranching enzyme GlgX; PFAM: glycoside hydrolase family 13 domain protein; alpha amylase catalytic region; SMART: alpha amylase catalytic sub domain; KEGG: msu:MS1122 pullulanase and related glycosidases YP_001344649.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_001344650.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_001344651.1 TIGRFAM: glycogen/starch/alpha-glucan phosphorylase; PFAM: glycosyl transferase family 35; KEGG: msu:MS1119 glucan phosphorylase YP_001344652.1 PFAM: putative esterase; KEGG: msu:MS2124 predicted hydrolase of the alpha/beta superfamily YP_001344653.1 PFAM: putative esterase; KEGG: msu:MS2123 hypothetical protein YP_001344654.1 PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; KEGG: msu:MS2122 hypothetical protein YP_001344655.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001344656.1 PFAM: protein of unknown function DUF1294; KEGG: msu:MS1294 hypothetical protein YP_001344657.1 PFAM: nucleic acid binding OB-fold tRNA/helicase-type; conserved hypothetical protein 156; KEGG: msu:MS1247 hypothetical protein YP_001344658.1 PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: pmu:PM0214 transcriptional regulatory protein, putative YP_001344659.1 PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: pmu:PM0215 sensor protein, putative YP_001344660.1 Involved in anaerobic NO protection and iron metabolism YP_001344661.1 PFAM: PEBP family protein; KEGG: msu:MS1376 hypothetical protein YP_001344662.1 PFAM: ATP-cone domain protein; KEGG: msu:MS1375 predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains YP_001344663.1 TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase zinc-binding; bifunctional deaminase-reductase domain protein; KEGG: pmu:PM0749 diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase YP_001344664.1 TIGRFAM: periplasmic serine protease DegS; PFAM: peptidase S1 and S6 chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: pmu:PM0748 protease DegS precursor YP_001344665.1 PFAM: Patatin; KEGG: msu:MS0145 RssA protein YP_001344666.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_001344667.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001344668.1 PFAM: Polyprenyl synthetase; KEGG: msu:MS1060 geranylgeranyl pyrophosphate synthase YP_001344669.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001344670.1 PFAM: glycosyl transferase family 25; KEGG: hdu:HD0472 lipooligosaccharide galactosyltransferase II YP_001344671.1 KEGG: aci:ACIAD0607 hypothetical protein YP_001344672.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_001344673.1 TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein domain I and II; MoeA domain protein domain IV; KEGG: msu:MS1005 molybdopterin biosynthesis enzyme YP_001344674.1 TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: hin:HI0041 exodeoxyribonuclease III YP_001344675.1 PFAM: conserved hypothetical protein 1619; protein of unknown function DUF1260; KEGG: msu:MS1049 hypothetical protein YP_001344676.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_001344677.1 TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain protein; KEGG: pmu:PM0635 folylpolyglutamate synthase / dihydrofolate synthase YP_001344678.1 PFAM: Phosphoglycerate mutase; KEGG: msu:MS1172 phosphoglycerate mutase/fructose-2, 6-bisphosphatase YP_001344679.1 TIGRFAM: aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; KEGG: msu:MS1034 aminopeptidase N YP_001344680.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001344681.1 PFAM: nitroreductase; KEGG: msu:MS1109 NfnB protein YP_001344682.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001344683.1 PFAM: Late embryogenesis abundant protein; KEGG: hit:NTHI1667 hypothetical protein YP_001344684.1 PFAM: protein of unknown function DUF709; KEGG: hso:HS_0805 hypothetical protein YP_001344685.1 KEGG: hin:HI1523 hypothetical protein YP_001344686.1 KEGG: hin:HI1522.1 hypothetical protein YP_001344687.1 KEGG: ecs:ECs4945 phage transposase YP_001344688.1 KEGG: hin:HI1477 DNA-binding protein YP_001344689.1 PFAM: helix-turn-helix domain protein; peptidase S24 S26A and S26B; bacteriophage CI repressor; KEGG: hin:HI1476 transcriptional regulatory protein YP_001344690.1 PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: msu:MS0808 PurR protein YP_001344691.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments YP_001344692.1 PFAM: glycoside hydrolase family 42 domain 5 loop region; glycoside hydrolase family 2 immunoglobulin domain protein beta-sandwich; glycoside hydrolase family 2 TIM barrel; glycoside hydrolase family 2 sugar binding; KEGG: msu:MS0806 beta-galactosidase/beta-glucuronidase YP_001344693.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001344694.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_001344695.1 PFAM: protein of unknown function DUF1508; KEGG: msu:MS1092 hypothetical protein YP_001344696.1 KEGG: hso:HS_0867 possible permease YP_001344697.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_001344698.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_001344699.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_001344700.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_001344701.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001344702.1 KEGG: bam:Bamb_2428 hypothetical protein YP_001344703.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions YP_001344704.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_001344705.1 PFAM: TatD-related deoxyribonuclease; KEGG: hit:NTHI0095 putative deoxyribonuclease YP_001344706.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001344707.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001344708.1 KEGG: vvy:VV1955 putative protein-S-isoprenylcysteine methyltransferase YP_001344709.1 PFAM: homocysteine S-methyltransferase; KEGG: msu:MS0553 MHT1 protein YP_001344710.1 PFAM: amino acid permease-associated region; KEGG: msu:MS0552 amino acid transporters YP_001344711.1 PFAM: NLP/P60 protein; KEGG: msu:MS1088 Spr protein YP_001344712.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001344713.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001344714.1 KEGG: pmu:PM0630 unknown YP_001344715.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001344716.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001344717.1 TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; KEGG: msu:MS0966 dihydropteroate synthase YP_001344718.1 PFAM: major facilitator superfamily MFS_1; KEGG: msu:MS1178 permeases of the major facilitator superfamily YP_001344719.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001344720.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_001344721.1 unwinds double stranded DNA YP_001344722.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_001344723.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001344724.1 TIGRFAM: lipoprotein releasing system, ATP-binding protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS1186 ABC-type transport systems, involved in lipoprotein release, ATPase components YP_001344725.1 TIGRFAM: lipoprotein releasing system, transmembrane protein, LolC/E family; PFAM: protein of unknown function DUF214; KEGG: msu:MS1187 ABC-type transport systems, involved in lipoprotein release, permease components YP_001344726.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor YP_001344727.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001344728.1 KEGG: msu:MS1190 hypothetical protein YP_001344729.1 TIGRFAM: modification methylase, HemK family; PFAM: methyltransferase small; ribosomal L11 methyltransferase; KEGG: hso:HS_0948 peptide release factor glutamine N(5)-methylase YP_001344730.1 PFAM: RDD domain containing protein; KEGG: hso:HS_0949 hypothetical protein YP_001344731.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001344732.1 TIGRFAM: phosphohistidine phosphatase SixA; PFAM: Phosphoglycerate mutase; KEGG: msu:MS1198 phosphohistidine phosphatase SixA YP_001344733.1 TIGRFAM: dihydroxyacetone kinase, phosphotransfer subunit; PFAM: PTS system fructose subfamily IIA component; KEGG: msu:MS1608 hypothetical protein YP_001344734.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone YP_001344735.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_001344736.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 YP_001344737.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_001344738.1 KEGG: msu:MS1195 predicted ATP-dependent protease YP_001344739.1 PFAM: protein of unknown function DUF1047; KEGG: msu:MS1196 hypothetical protein YP_001344740.1 TIGRFAM: cold shock domain protein CspD; PFAM: Cold-shock protein DNA-binding; SMART: Cold shock protein; KEGG: msu:MS1095 cold shock proteins YP_001344741.1 TIGRFAM: ribosomal protein L20; KEGG: pmu:PM0604 50S ribosomal protein L20 YP_001344742.1 PFAM: ribosomal protein L35; KEGG: pmu:PM0603 50S ribosomal protein L35 YP_001344743.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001344744.1 PFAM: protein of unknown function DUF945; KEGG: msu:MS0897 hypothetical protein YP_001344745.1 PFAM: protein of unknown function DUF462; KEGG: hin:HI1563 hypothetical protein YP_001344746.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001344747.1 KEGG: msu:MS1137 predicted ATP-dependent endonuclease of the OLD family YP_001344748.1 PFAM: protein of unknown function DUF340 membrane; KEGG: msu:MS1138 hypothetical protein YP_001344750.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001344751.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001344752.1 PFAM: protein of unknown function UPF0044; KEGG: hso:HS_1001 conserved hypothetical protein YP_001344753.1 KEGG: hso:HS_0725 cell division protein; TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: peptidase M41; AAA ATPase central domain protein; peptidase M41 FtsH extracellular; SMART: AAA ATPase YP_001344754.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_001344755.1 KEGG: msu:MS1290 GmhA protein YP_001344756.1 PFAM: protein of unknown function UPF0102; KEGG: hit:NTHI1958 predicted endonuclease distantly related to archaeal holliday junction resolvase YP_001344757.1 PFAM: LppC family lipoprotein; KEGG: msu:MS1288 putative lipoprotein YP_001344758.1 PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pmu:PM0645 hypothetical HI1654 YP_001344759.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_001344760.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001344761.1 KEGG: msu:MS1740 hypothetical protein YP_001344762.1 PFAM: Na+ symporter; KEGG: msu:MS1741 PutP protein YP_001344763.1 KEGG: msu:MS1742 hypothetical protein YP_001344764.1 PFAM: Cupin 2 conserved barrel domain protein; KEGG: msu:MS0567 hypothetical protein YP_001344765.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_001344766.1 PFAM: PfkB domain protein; KEGG: msu:MS0565 sugar kinases, ribokinase family YP_001344767.1 PFAM: Ribose/galactose isomerase; KEGG: msu:MS0564 hypothetical protein YP_001344768.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_001344769.1 PFAM: regulatory protein IclR; Transcriptional regulator IclR; KEGG: msu:MS0562 IclR protein YP_001344770.1 PFAM: porin Gram-negative type; KEGG: msu:MS0561 OmpC protein YP_001344771.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001344772.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001344773.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_001344774.1 PFAM: ferredoxin; KEGG: hso:HS_0962 possible ferredoxin, 2Fe-2S type YP_001344775.1 TIGRFAM: anion transporter; PFAM: sodium/sulphate symporter; Citrate transporter; KEGG: msu:MS0970 di- and tricarboxylate transporters YP_001344776.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001344777.1 PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: hso:HS_0834 possible lysine exporter protein YP_001344778.1 PFAM: phosphatidylglycerophosphatase A; KEGG: hin:HI1306 phosphatidylglycerophosphatase A YP_001344779.1 TIGRFAM: thiamine-monophosphate kinase; PFAM: AIR synthase related protein domain protein; KEGG: msu:MS0974 thiamine monophosphate kinase YP_001344780.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001344781.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001344782.1 TIGRFAM: aromatic amino acid transporter; PFAM: aromatic amino acid permease; Amino acid transporter transmembrane; KEGG: msu:MS0977 SdaC protein YP_001344783.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001344784.1 PFAM: Stringent starvation protein B; KEGG: hit:NTHI1690 stringent starvation protein B YP_001344785.1 PFAM: Glutathione S-transferase domain; KEGG: msu:MS1281 glutathione-S-transferases YP_001344786.1 forms a direct contact with the tRNA during translation YP_001344787.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001344788.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_001344789.1 PFAM: Pyridoxal-dependent decarboxylase; KEGG: msu:MS0827 glutamate decarboxylase and related PLP-dependent proteins YP_001344790.1 PFAM: protein of unknown function DUF1043; KEGG: pmu:PM0688 hypothetical HI1628 YP_001344791.1 PFAM: Cupin 2 conserved barrel domain protein; KEGG: fnu:FN0550 mannose-6-phosphate isomerase / mannose-1-phosphate guanylyl transferase (GDP) YP_001344792.1 TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: msu:MS1461 hydrogenase maturation factor YP_001344793.1 TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; KEGG: msu:MS1462 hydrogenase maturation factor YP_001344794.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_001344795.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_001344796.1 PFAM: phosphoesterase PA-phosphatase related; KEGG: msu:MS1532 membrane-associated phospholipid phosphatase YP_001344797.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_001344798.1 PFAM: protein of unknown function DUF419; KEGG: msu:MS0577 MmcQ protein YP_001344799.1 PFAM: hydroxyethylthiazole kinase; KEGG: hin:HI0415 hydroxyethylthiazole kinase YP_001344800.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001344801.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_001344802.1 TIGRFAM: ornithine carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; KEGG: msu:MS1073 ornithine carbamoyltransferase YP_001344803.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_001344804.1 KEGG: msu:MS1538 TrxA protein YP_001344805.1 TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; KEGG: msu:MS1539 single-stranded DNA-specific exonuclease YP_001344806.1 KEGG: msu:MS1540 DsbG protein YP_001344807.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_001344808.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001344809.1 TIGRFAM: hydrogenase nickel insertion protein HypA; PFAM: hydrogenase expression/synthesis HypA; KEGG: msu:MS1545 HybF protein YP_001344810.1 PFAM: cation efflux protein; KEGG: msu:MS1434 Co/Zn/Cd efflux system component YP_001344811.1 PFAM: regulatory protein MerR; Transcription regulator MerR DNA binding; KEGG: msu:MS1433 SoxR protein YP_001344812.1 TIGRFAM: ferredoxin-type protein NapF; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: msu:MS2334 NapF protein YP_001344813.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_001344814.1 PFAM: DMSO reductase anchor subunit (DmsC); KEGG: hit:NTHI1205 anaerobic dimethyl sulfoxide reductase chain C YP_001344815.1 TIGRFAM: Dimethylsulfoxide reductase chain B; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: hit:NTHI1206 anaerobic dimethyl sulfoxide reductase chain B YP_001344816.1 TIGRFAM: anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: pmu:PM1754 anaerobic dimethyl sulfoxide reductase, chain A YP_001344817.1 TIGRFAM: anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: ecv:APECO1_670 putative dimethyl sulfoxide reductase chain YnfE precursor YP_001344818.1 PFAM: extracellular solute-binding protein family 1; KEGG: msu:MS0580 PotD protein YP_001344819.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS0581 PotC protein YP_001344820.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS0583 ABC-type spermidine/putrescine transport system, permease component I YP_001344821.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS0584 MalK protein YP_001344822.1 PFAM: 2-nitropropane dioxygenase NPD; KEGG: sab:SAB1837 hypothetical protein YP_001344823.1 KEGG: msu:MS1416 hypothetical protein YP_001344824.1 PFAM: NAD(P)H dehydrogenase (quinone); KEGG: msu:MS2139 putative NADPH-quinone reductase (modulator of drug activity B) YP_001344825.1 PFAM: Antibiotic biosynthesis monooxygenase; KEGG: msu:MS1429 hypothetical protein YP_001344826.1 PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: msu:MS2163 FabG protein YP_001344827.1 PFAM: aldo/keto reductase; KEGG: msu:MS1422 Tas protein YP_001344828.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: eca:ECA1482 LysR-family transcriptional regulator YP_001344829.1 KEGG: dsy:DSY2532 hypothetical protein YP_001344831.1 PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: bam:Bamb_5387 alcohol dehydrogenase, zinc-binding domain protein YP_001344832.1 PFAM: beta-lactamase domain protein; KEGG: msu:MS2011 GloB protein YP_001344833.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: msu:MS2116 LysR protein YP_001344834.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: par:Psyc_0050 probable transcriptional regulator, LysR family YP_001344835.1 PFAM: nitroreductase; KEGG: msu:MS2115 NfnB protein YP_001344836.1 involved in start site selection during the initiation of translation YP_001344837.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_001344838.1 SMART: Tetratricopeptide domain protein; KEGG: msu:MS1473 hypothetical protein YP_001344839.1 PFAM: protein of unknown function DUF1049; KEGG: msu:MS1474 hypothetical protein YP_001344840.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001344841.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001344842.1 TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region; KEGG: pmu:PM0802 cytidylate kinase 1 YP_001344843.1 PFAM: protein of unknown function DUF535; KEGG: hso:HS_1361 hypothetical protein YP_001344844.1 PFAM: Lytic transglycosylase catalytic; KEGG: msu:MS1565 soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) YP_001344845.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_001344846.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_001344847.1 TIGRFAM: RarD protein, DMT superfamily transporter; PFAM: protein of unknown function DUF6 transmembrane; KEGG: msu:MS0578 predicted permeases YP_001344848.1 TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: msu:MS1342 ABC-type molybdate transport system, periplasmic component YP_001344849.1 TIGRFAM: molybdate transport repressor, ModE; PFAM: regulatory protein LysR; TOBE domain protein; Transport-associated OB domain protein; KEGG: pmu:PM0746 molybdenum transport protein YP_001344850.1 PFAM: thioesterase superfamily protein; KEGG: hso:HS_1045 hypothetical protein YP_001344851.1 PFAM: ferrochelatase; KEGG: hit:NTHI1329 ferrochelatase YP_001344852.1 KEGG: msu:MS1350 hypothetical protein YP_001344853.1 TIGRFAM: succinyl-CoA synthetase, alpha subunit; PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase; KEGG: hin:HI1197 succinyl-CoA synthetase alpha chain YP_001344854.1 TIGRFAM: succinyl-CoA synthetase, beta subunit; PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein; KEGG: msu:MS1352 succinyl-CoA synthetase beta subunit YP_001344855.1 TIGRFAM: 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: msu:MS1354 dihydrolipoamide acyltransferases YP_001344856.1 TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase E1 component; Transketolase central region; KEGG: msu:MS1355 pyruvate and 2-oxoglutarate dehydrogenases, E1 component YP_001344857.1 TIGRFAM: anion transporter; PFAM: sodium/sulphate symporter; Citrate transporter; KEGG: msu:MS1915 CitT protein YP_001344858.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_001344859.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_001344860.1 TIGRFAM: signal peptide peptidase SppA, 67K type; signal peptide peptidase SppA, 36K type; PFAM: peptidase S49; KEGG: hin:HI1541 protease IV (endopeptidase IV) YP_001344861.1 TIGRFAM: phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: msu:MS1033 phosphoribosylcarboxyaminoimidazole (NCAIR) mutase YP_001344862.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001344863.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001344864.1 PFAM: triosephosphate isomerase; phosphotransferase system PTS EIIB protein; KEGG: pmu:PM1640 triosephosphate isomerase YP_001344865.1 PFAM: cyclase family protein; KEGG: pmu:PM1641 hypothetical Synechocystis sp. YP_001344866.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: pmu:PM1642 hypothetical E.coli YP_001344867.1 PFAM: Tripartite ATP-independent periplasmic transporter DctQ component; KEGG: pmu:PM1643 unknown YP_001344868.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit; KEGG: pmu:PM1644 hypothetical HI1028 YP_001344869.1 TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; KEGG: pmu:PM1645 ribose-5-phosphate isomerase YP_001344870.1 PFAM: putative sugar-binding domain protein; KEGG: pmu:PM1646 SmoC-like regulatory protein YP_001344871.1 PFAM: Xylose isomerase domain protein TIM barrel; KEGG: pmu:PM1647 unknown YP_001344872.1 PFAM: amidohydrolase 2; KEGG: pau:PA14_36110 putative hydrolase YP_001344873.1 PFAM: major facilitator superfamily MFS_1; KEGG: pau:PA14_36120 putative MFS transporter YP_001344874.1 TIGRFAM: dihydroxyacetone kinase, L subunit; PFAM: Dak phosphatase; KEGG: pmu:PM1648 putative dihydroxyacetone kinase YP_001344875.1 PFAM: Dak kinase; KEGG: pmu:PM1649 dihydroxyacetone kinase YP_001344876.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_001344877.1 PFAM: peptidase M3A and M3B thimet/oligopeptidase F; KEGG: msu:MS1199 zn-dependent oligopeptidases YP_001344878.1 PFAM: Thioredoxin domain; KEGG: msu:MS0952 thioredoxin domain-containing protein YP_001344879.1 TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: pmu:PM0573 thioredoxin reductase (NADPH) YP_001344880.1 PFAM: ferredoxin; KEGG: cya:CYA_1426 ferredoxin, 2Fe-2S YP_001344884.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001344885.1 transports degraded pectin products into the bacterial cell YP_001344886.1 TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; KEGG: msu:MS0383 ribose 5-phosphate isomerase RpiB YP_001344887.1 KEGG: msu:MS0382 hypothetical protein YP_001344888.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_001344889.1 PFAM: regulatory protein DeoR; Helix-turn-helix type 11 domain protein; regulatory protein DeoR; KEGG: msu:MS0380 GlpR protein YP_001344890.1 PFAM: triosephosphate isomerase; KEGG: pmu:PM1640 triosephosphate isomerase YP_001344891.1 KEGG: msu:MS0294 nitric oxide reductase large subunit YP_001344892.1 PFAM: major intrinsic protein; KEGG: msu:MS1990 glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) YP_001344893.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_001344894.1 PFAM: protein of unknown function UPF0125; KEGG: msu:MS0558 hypothetical protein YP_001344895.1 PFAM: protein of unknown function DUF6 transmembrane; KEGG: msu:MS0557 hypothetical protein YP_001344896.1 PFAM: Ferritin Dps family protein; KEGG: pmu:PM0666 ferritin like protein 1 YP_001344897.1 PFAM: Ferritin Dps family protein; KEGG: hit:NTHI1772 ferritin like protein 2 YP_001344899.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_001344900.1 with UspC and UspD is involved in resistance to UV irradiation YP_001344901.1 oxidizes malate to oxaloacetate YP_001344902.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001344903.1 PFAM: NAD-dependent epimerase/dehydratase; Male sterility domain; domain of unknown function DUF1731; KEGG: msu:MS1268 predicted nucleoside-diphosphate sugar epimerases (SulA family) YP_001344904.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_001344905.1 PFAM: LrgB family protein; KEGG: msu:MS1270 LrgB protein YP_001344906.1 PFAM: LrgA family protein; KEGG: msu:MS1271 putative effector of murein hydrolase LrgA YP_001344907.1 PFAM: nuclease (SNase domain protein); KEGG: msu:MS1272 hypothetical protein YP_001344908.1 PFAM: aminotransferase class V; KEGG: msu:MS1273 selenocysteine lyase YP_001344909.1 PFAM: Fe-S metabolism associated SufE; KEGG: pmu:PM0883 hypothetical HI1293/94 YP_001344910.1 KEGG: yps:YPTB3260 hypothetical protein YP_001344911.1 PFAM: protein of unknown function UPF0052 and CofD; KEGG: hso:HS_0896 hypothetical protein YP_001344912.1 TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: pmu:PM0738 cystathionine beta-lyase, putative YP_001344913.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: msu:MS1421 FabG protein YP_001344914.1 TIGRFAM: [NiFe] hydrogenase maturation protein HypF; PFAM: acylphosphatase; SUA5/yciO/yrdC domain; zinc finger HypF domain protein; KEGG: msu:MS1546 hydrogenase maturation factor YP_001344915.1 PFAM: regulatory protein MarR; KEGG: eca:ECA1023 MarR-family transcriptional regulator YP_001344916.1 PFAM: transmembrane pair domain protein; KEGG: vfi:VFA1143 hypothetical membrane spanning protein YP_001344917.1 PFAM: protein of unknown function DUF333; KEGG: nma:NMA0983 haemolysin YP_001344919.1 KEGG: pgi:PG0223 exonuclease YP_001344920.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pau:PA14_01500 putative transcriptional regulator YP_001344921.1 PFAM: small multidrug resistance protein; KEGG: cff:CFF8240_1336 chaperonin YP_001344922.1 PFAM: small multidrug resistance protein; KEGG: hhe:HH1452 conserved hypothetical membrane protein YP_001344923.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: cac:CAC1464 UvrA-like protein, probably involved in MDR transport YP_001344924.1 PFAM: protein of unknown function DUF45; KEGG: yps:YPTB3878 putative predicted metal-dependent hydrolase YP_001344925.1 TIGRFAM: type I site-specific deoxyribonuclease, HsdR family; PFAM: type III restriction protein res subunit; protein of unknown function DUF450; SMART: DEAD-like helicases; KEGG: yps:YPTB3879 possible type I restriction enzyme (restriction subunit) YP_001344926.1 PFAM: restriction modification system DNA specificity domain; KEGG: bth:BT_4543 putative type I restriction enzyme specificity protein YP_001344927.1 TIGRFAM: type I restriction-modification system, M subunit; PFAM: N-6 DNA methylase; KEGG: gox:GOX2569 type I restriction enzyme M protein YP_001344928.1 KEGG: sbo:SBO_3734 DNA-damage-inducible protein YP_001344929.1 PFAM: restriction modification system DNA specificity domain; KEGG: gox:GOX2570 hypothetical protein YP_001344930.1 PFAM: alpha/beta hydrolase fold; KEGG: bcl:ABC1422 lysophospholipase YP_001344931.1 PFAM: Glutathione S-transferase domain; KEGG: msu:MS2100 Gst protein YP_001344932.1 PFAM: Glutathione S-transferase domain; KEGG: bam:Bamb_5570 glutathione S-transferase, N-terminal domain YP_001344933.1 PFAM: NAD(P)H dehydrogenase (quinone); KEGG: hso:HS_0336 NAD(P)H dehydrogenase (quinone) YP_001344934.1 PFAM: Alpha/beta hydrolase fold-3 domain protein; KEGG: msu:MS2161 Aes protein YP_001344935.1 PFAM: OsmC family protein; KEGG: msu:MS2101 OsmC protein YP_001344936.1 PFAM: nitroreductase; KEGG: msu:MS2149 NfnB protein YP_001344937.1 PFAM: protein of unknown function DUF419; KEGG: msu:MS0577 MmcQ protein YP_001344938.1 PFAM: HpcH/HpaI aldolase; KEGG: msu:MS2103 PykF protein YP_001344939.1 PFAM: Ferritin Dps family protein; KEGG: msu:MS2104 bacterioferritin (cytochrome b1) YP_001344940.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: msu:MS2153 NemA protein YP_001344941.1 KEGG: msu:MS2154 hypothetical protein YP_001344942.1 KEGG: lpl:lp_1348 hypothetical protein YP_001344943.1 PFAM: DSBA oxidoreductase; KEGG: msu:MS2155 hypothetical protein YP_001344944.1 PFAM: beta-lactamase domain protein; KEGG: msu:MS2011 GloB protein YP_001344945.1 PFAM: 2-nitropropane dioxygenase NPD; KEGG: sab:SAB1837 hypothetical protein YP_001344946.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: bch:Bcen2424_3647 transcriptional regulator, LysR family YP_001344947.1 PFAM: helix-turn-helix- domain containing protein AraC type; AraC-type transcriptional regulator domain protein; KEGG: msu:MS2105 AraC protein YP_001344948.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001344949.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_001344950.1 PFAM: iron permease FTR1; KEGG: pmu:PM0453 high-affinity iron transporter YP_001344951.1 KEGG: pmu:PM0452 hypothetical Y.pestis YP_001344952.1 PFAM: YHS domain protein; KEGG: pmu:PM0451 hypothetical Y.pestis YP_001344953.1 PFAM: protein of unknown function DUF214; KEGG: pmu:PM0450 hypothetical ABC transporter YP_001344954.1 PFAM: protein of unknown function DUF214; KEGG: pmu:PM0449 hypothetical Y. pestis YP_001344955.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pmu:PM0448 hypothetical Y. pestis YP_001344956.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: pmu:PM0447 cytochrome c biogenesis protein, putative YP_001344957.1 PFAM: cytochrome c class I; KEGG: pmu:PM0446 cytochrome c-553 homolog YP_001344958.1 TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS); KEGG: hso:HS_0918 polysialic acid capsule expression protein, KpsF/GutQ family protein YP_001344959.1 TIGRFAM: hydrolase, HAD-superfamily, subfamily IIIA; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; KEGG: hit:NTHI1982 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_001344960.1 PFAM: Invasion gene expression up-regulator SirB; KEGG: msu:MS1469 hypothetical protein YP_001344961.1 PFAM: molybdopterin biosynthesis MoaE protein; KEGG: msu:MS1024 molybdopterin converting factor, large subunit YP_001344962.1 TIGRFAM: molybdopterin converting factor, subunit 1; PFAM: thiamineS protein; KEGG: hso:HS_1029 molybdopterin biosynthesis protein, D chain YP_001344963.1 TIGRFAM: molybdenum cofactor biosynthesis protein C; PFAM: molybdopterin cofactor biosynthesis MoaC region; KEGG: msu:MS1022 molybdenum cofactor biosynthesis enzyme YP_001344964.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001344965.1 PFAM: branched-chain amino acid transport; KEGG: msu:MS0765 AzlD protein YP_001344966.1 PFAM: AzlC family protein; KEGG: hit:NTHI2047 predicted branched-chain amino acid permease YP_001344967.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: msu:MS0763 transcriptional regulator YP_001344968.1 PFAM: extracellular solute-binding protein family 1; KEGG: msu:MS1583 ABC-type iron/thiamine transport systems, periplasmic component YP_001344969.1 PFAM: extracellular solute-binding protein family 1; KEGG: msu:MS1585 ABC-type iron/thiamine transport systems, periplasmic component YP_001344970.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS1586 ABC-type thiamine transport system, permease components YP_001344971.1 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import YP_001344972.1 KEGG: msu:MS1011 hypothetical protein YP_001344973.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_001344974.1 TIGRFAM: sulfite reductase [NADPH] flavoprotein, alpha chain; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; FAD-binding domain protein; flavodoxin/nitric oxide synthase; KEGG: msu:MS1250 sulfite reductase flavoprotein subunit YP_001344975.1 TIGRFAM: sulfate adenylyltransferase, large subunit; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; KEGG: msu:MS1251 GTPases - sulfate adenylate transferase subunit 1 YP_001344976.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_001344977.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_001344978.1 TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: msu:MS1254 uroporphyrinogen-III methylase YP_001344979.1 TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; KEGG: msu:MS1255 ABC-type sulfate transport system, periplasmic component YP_001344980.1 TIGRFAM: sulfate ABC transporter, inner membrane subunit; sulfate ABC transporter, inner membrane subunit CysT; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS1259 ABC-type sulfate/molybdate transport systems, permease components YP_001344981.1 TIGRFAM: sulfate ABC transporter, inner membrane subunit; sulfate ABC transporter, inner membrane subunit CysW; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS1260 ABC-type sulfate/molybdate transport systems, permease components YP_001344982.1 TIGRFAM: sulfate ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS1261 ABC-type sulfate/molybdate transport systems, ATPase component YP_001344983.1 KEGG: msu:MS0894 predicted SAM-dependent methyltransferase YP_001344984.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_001344985.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001344986.1 TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; KEGG: msu:MS0959 phosphatidylglycerophosphate synthase YP_001344987.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_001344988.1 PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: msu:MS1038 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases YP_001344989.1 TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5/yciO/yrdC domain; KEGG: msu:MS1037 putative translation factor (SUA5) YP_001344990.1 PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: pmu:PM0791 gluconate utilization system gnt-I, repressor YP_001344991.1 TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: msu:MS0732 uncharacterized anaerobic dehydrogenase YP_001344992.1 unknown function YP_001344993.1 decatenates replicating daughter chromosomes YP_001344994.1 TIGRFAM: preprotein translocase, SecG subunit; PFAM: Preprotein translocase SecG subunit; KEGG: msu:MS0729 preprotein translocase subunit YP_001344995.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001344996.1 PFAM: Colicin V production protein; KEGG: msu:MS1002 uncharacterized membrane protein, required for colicin V production YP_001344997.1 PFAM: protein of unknown function DUF412; KEGG: hso:HS_0804 hypothetical protein YP_001344998.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001344999.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001345000.1 PFAM: SNARE associated Golgi protein; KEGG: hit:NTHI1412 uncharacterized membrane-associated protein YP_001345001.1 with TehA confers resistance to tellurite YP_001345002.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pmu:PM1454 multiple sugar-binding transport ATP binding protein YP_001345003.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: pmu:PM1455 AfuB homolog YP_001345004.1 PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase; KEGG: pmu:PM1456 ATP-binding transport protein, putative YP_001345005.1 PFAM: extracellular solute-binding protein family 1; KEGG: pmu:PM1457 periplasmic iron-binding protein, putative YP_001345006.1 KEGG: pmu:PM1458 phosphoglycerate transport regulatory protein YP_001345007.1 PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: pmu:PM1459 phosphoglycerate transport regulatory protein YP_001345008.1 PFAM: response regulator receiver; helix-turn-helix Fis-type; KEGG: pmu:PM1460 phosphoglycerate transport system activator protein YP_001345009.1 PFAM: protein of unknown function UPF0181; KEGG: pmu:PM0480 unknown YP_001345010.1 KEGG: msu:MS1222 Mug protein YP_001345011.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001345012.1 PFAM: protein of unknown function DUF937; KEGG: msu:MS0936 hypothetical protein YP_001345013.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001345014.1 TIGRFAM: tetraacyldisaccharide 4'-kinase; PFAM: Tetraacyldisaccharide-1-P 4'-kinase; KEGG: msu:MS0933 lipid A biosynthesis protein LpxK, tetraacyldisaccharide-1-P 4'-kinase YP_001345015.1 involved in the transport of lipid A across the inner membrane YP_001345016.1 TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; PFAM: beta-lactamase domain protein; ComEC/Rec2-related protein; KEGG: hit:NTHI0073 recombination protein 2 YP_001345017.1 TIGRFAM: RNA polymerase-binding protein DksA; PFAM: zinc finger DksA/TraR C4-type; KEGG: msu:MS0927 DnaK suppressor protein YP_001345018.1 TIGRFAM: poly(A) polymerase; PFAM: Polynucleotide adenylyltransferase region; KEGG: pmu:PM0864 poly(A) polymerase YP_001345019.1 TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; KEGG: hit:NTHI0077 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase YP_001345020.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_001345021.1 PFAM: protein of unknown function DUF218; KEGG: msu:MS0923 uncharacterized membrane protein YP_001345022.1 TIGRFAM: electron transport complex, RnfABCDGE type, A subunit; PFAM: RnfA-Nqr electron transport subunit; KEGG: hso:HS_1059 electron transport complex protein YP_001345023.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001345024.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001345025.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_001345026.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_001345027.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_001345028.1 KEGG: pmu:PM0381 endonuclease III; TIGRFAM: endonuclease III; PFAM: helix-hairpin-helix motif; HhH-GPD family protein; SMART: iron-sulfur cluster loop YP_001345029.1 PFAM: sodium:neurotransmitter symporter; KEGG: msu:MS0914 Na+-dependent transporters of the SNF family YP_001345030.1 PFAM: extracellular solute-binding protein family 1; KEGG: msu:MS0809 spermidine/putrescine-binding periplasmic protein YP_001345031.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_001345032.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_001345033.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_001345034.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001345035.1 Required for the synthesis of the thiazole moiety YP_001345036.1 catalyzes the formation of selenophosphate from selenide and ATP YP_001345037.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_001345038.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001345039.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001345040.1 negatively supercoils closed circular double-stranded DNA YP_001345041.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pmu:PM0915 peptide ABC transporter, ATP-binding protein YP_001345042.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter domain protein; SMART: AAA ATPase; KEGG: msu:MS0853 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component YP_001345043.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS0854 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_001345044.1 PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS0855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components YP_001345045.1 PFAM: extracellular solute-binding protein family 5; KEGG: msu:MS0856 ABC-type dipeptide/oligopeptide/nickel transport systems, periplasmic components YP_001345046.1 PFAM: protein of unknown function DUF463 YcjX family protein; KEGG: pmu:PM0910 hypothetical HI1637 YP_001345047.1 TIGRFAM: undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; PFAM: glycosyl transferase family 4; KEGG: msu:MS0911 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase YP_001345048.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001345049.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001345050.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001345051.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001345052.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_001345053.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001345054.1 PFAM: MOSC domain containing protein; KEGG: msu:MS1884 hypothetical protein YP_001345055.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001345056.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001345057.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_001345058.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001345059.1 TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: hin:HI1227 probable uracil permease (uracil transporter) YP_001345060.1 PFAM: glutamine amidotransferase class-II; KEGG: msu:MS0621 predicted glutamine amidotransferase YP_001345061.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001345062.1 PFAM: peptidyl-prolyl cis-trans isomerase cyclophilin type; KEGG: msu:MS0623 peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family YP_001345063.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001345064.1 PFAM: protein of unknown function UPF0126; KEGG: msu:MS1605 hypothetical protein YP_001345065.1 PFAM: metallophosphoesterase; KEGG: msu:MS1630 predicted phosphohydrolases YP_001345066.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001345067.1 KEGG: hdu:HD0606 hypothetical protein YP_001345068.1 KEGG: hdu:HD0607 hypothetical protein YP_001345069.1 involved in transport of zinc(II) with ZnuA and C YP_001345070.1 PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: msu:MS1458 hypothetical protein YP_001345071.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001345072.1 TIGRFAM: exodeoxyribonuclease V, gamma subunit; PFAM: Exodeoxyribonuclease V RecC subunit; KEGG: msu:MS0728 exonuclease V gamma subunit YP_001345073.1 KEGG: hin:HI0941 hypothetical protein YP_001345074.1 KEGG: hso:HS_0266 hypothetical protein YP_001345075.1 KEGG: pmu:PM0964 hypothetical HI0939 YP_001345076.1 KEGG: hso:HS_0264 type II secretory pathway, pseudopilin YP_001345077.1 TIGRFAM: Peptidoglycan-associated lipoprotein; PFAM: OmpA/MotB domain protein; KEGG: hit:NTHI0501 outer membrane protein P6 precursor YP_001345078.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001345079.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001345080.1 TIGRFAM: Tol-Pal system TolQ; PFAM: MotA/TolQ/ExbB proton channel; KEGG: pmu:PM0970 colicin transport protein YP_001345081.1 TIGRFAM: Pol-Pal system-associated acyl-CoA thioesterase; PFAM: thioesterase superfamily protein; KEGG: hit:NTHI0506 predicted thioesterase YP_001345082.1 TIGRFAM: cytochrome d ubiquinol oxidase, subunit II; PFAM: cytochrome bd ubiquinol oxidase subunit II; KEGG: msu:MS0716 cytochrome bd-type quinol oxidase, subunit 2 YP_001345083.1 PFAM: cytochrome bd ubiquinol oxidase subunit I; KEGG: msu:MS0715 cytochrome bd-type quinol oxidase, subunit 1 YP_001345084.1 KEGG: msu:MS0714 hypothetical protein YP_001345085.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001345086.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001345087.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001345088.1 KEGG: hdu:HD0595 hypothetical protein YP_001345089.1 PFAM: protein of unknown function DUF28; KEGG: msu:MS0710 hypothetical protein YP_001345090.1 converts dATP to dAMP and pyrophosphate YP_001345091.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001345092.1 TIGRFAM: putative methyltransferase; PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: msu:MS0706 SmtA protein YP_001345093.1 PFAM: extracellular solute-binding protein family 3; SMART: ionotropic glutamate receptor; KEGG: msu:MS0704 ABC-type amino acid transport system, periplasmic component YP_001345094.1 TIGRFAM: lactoylglutathione lyase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: msu:MS0703 lactoylglutathione lyase and related lyases YP_001345095.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_001345096.1 PFAM: Gluconate transporter; Citrate transporter; Na+ antiporter NhaC; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: msu:MS0701 predicted permease YP_001345097.1 KEGG: msu:MS0700 hypothetical protein YP_001345098.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001345099.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001345100.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001345101.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001345102.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_001345103.1 TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; Male sterility domain; KEGG: msu:MS0798 UDP-glucose 4-epimerase YP_001345104.1 TIGRFAM: AmpG-related permease; PFAM: major facilitator superfamily MFS_1; KEGG: hso:HS_0600 AmpG protein YP_001345105.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001345106.1 PFAM: periplasmic binding protein; KEGG: msu:MS0795 ABC-type Fe3+-siderophores transport systems, periplasmic components YP_001345107.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS0794 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components YP_001345108.1 PFAM: transport system permease protein; KEGG: msu:MS0793 ABC-type cobalamin/Fe3+-siderophores transport systems, permease components YP_001345109.1 PFAM: transport system permease protein; ABC-3 protein; KEGG: msu:MS0792 ABC-type cobalamin/Fe3+-siderophores transport systems, permease components YP_001345110.1 PFAM: peptidase M23B; KEGG: msu:MS0791 NlpD protein YP_001345111.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS0790 ABC-type Mn/Zn transport systems, ATPase component YP_001345112.1 PFAM: ABC-3 protein; KEGG: msu:MS0789 ABC-type Mn2+/Zn2+ transport systems, permease components YP_001345113.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001345114.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least YP_001345115.1 TIGRFAM: sucrose-6-phosphate hydrolase; PFAM: Glycosyl hydrolase family 32 domain protein; SMART: glycoside hydrolase family 32; KEGG: msu:MS0909 beta-fructosidases (levanase/invertase) YP_001345116.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001345117.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001345118.1 KEGG: msu:MS1632 ATPases involved in chromosome partitioning YP_001345119.1 KEGG: hso:HS_1015a hypothetical protein YP_001345120.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_001345122.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_001345123.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_001345124.1 TIGRFAM: ribonuclease, Rne/Rng family; PFAM: RNA binding S1 domain protein; KEGG: msu:MS1622 ribonucleases G and E YP_001345125.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_001345127.1 PFAM: peptidase M16 domain protein; KEGG: eca:ECA0879 putative zinc protease YP_001345128.1 PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: eca:ECA0878 hypothetical protein YP_001345129.1 KEGG: rno:689787 hypothetical protein LOC689787 YP_001345130.1 PFAM: protein of unknown function DUF560; KEGG: hso:HS_0622 hypothetical protein YP_001345131.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: hso:HS_1344 thioredoxin YP_001345132.1 catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity YP_001345133.1 PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: msu:MS0689 O-succinylbenzoate synthase and related enzymes YP_001345134.1 TIGRFAM: gluconate transporter; PFAM: Gluconate transporter; Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: msu:MS0688 GntT protein YP_001345135.1 PFAM: Uncharacterized protein UPF0065; KEGG: oih:OB2837 hypothetical protein YP_001345136.1 KEGG: oih:OB2839 hypothetical protein YP_001345137.1 PFAM: protein of unknown function DUF112 transmembrane; KEGG: oih:OB2838 putative tricarboxylic transport membrane protein YP_001345138.1 PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: ecv:APECO1_3743 glucarate dehydratase-related protein YP_001345139.1 PFAM: aldo/keto reductase; KEGG: msu:MS0687 ARA1 protein YP_001345140.1 PFAM: Arylesterase; SMP-30/Gluconolaconase/LRE domain protein; KEGG: msu:MS0684 gluconolactonase YP_001345141.1 PFAM: D-galactarate dehydratase/Altronate hydrolase domain protein; SAF domain protein; KEGG: msu:MS0695 altronate dehydratase YP_001345142.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization YP_001345143.1 PFAM: glycerate kinase; KEGG: msu:MS0693 glycerate kinase YP_001345144.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_001345145.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate YP_001345146.1 Required for efficient pilin antigenic variation YP_001345147.1 PFAM: Chromosomal replication initiator DnaA; KEGG: msu:MS1878 ATPase involved in DNA replication initiation YP_001345148.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001345149.1 PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region; KEGG: msu:MS0573 hypothetical protein YP_001345150.1 PFAM: protein of unknown function DUF1523; KEGG: msu:MS0572 hypothetical protein YP_001345151.1 TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease; KEGG: hit:NTHI0581 putative deoxyribonuclease YP_001345152.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001345153.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001345154.1 PFAM: aminodeoxychorismate lyase; KEGG: msu:MS0568 predicted periplasmic solute-binding protein YP_001345155.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001345156.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001345157.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001345158.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001345159.1 TIGRFAM: competence protein ComEA helix-hairpin-helix repeat protein; KEGG: hit:NTHI1183 hypothetical protein YP_001345160.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001345161.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001345162.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001345163.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001345164.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_001345165.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001345166.1 TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; KEGG: msu:MS0585 single-stranded DNA-binding protein YP_001345167.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_001345168.1 TIGRFAM: dihydroneopterin aldolase; KEGG: msu:MS1824 dihydroneopterin aldolase YP_001345169.1 Multifunctional regulator of fatty acid metabolism YP_001345170.1 involved in regulation of intracellular pH under alkaline conditions YP_001345171.1 PFAM: Disulphide bond formation protein DsbB; KEGG: msu:MS0429 disulfide bond formation protein DsbB YP_001345172.1 PFAM: protein of unknown function UPF0118; KEGG: msu:MS0428 PerM protein YP_001345173.1 PFAM: cytochrome b562; KEGG: msu:MS0427 hypothetical protein YP_001345174.1 PFAM: nitrogen regulatory protein P-II; KEGG: pmu:PM2004 nitrogen regulatory protein P-II YP_001345175.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_001345176.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001345177.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001345178.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001345179.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001345180.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_001345181.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_001345182.1 PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: msu:MS0643 periplasmic sugar-binding proteins YP_001345183.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_001345184.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001345185.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_001345186.1 TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: msu:MS0575 xanthine/uracil permeases YP_001345187.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_001345188.1 TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: methylguanine DNA methyltransferase ribonuclease domain protein; Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; KEGG: msu:MS0637 methylated DNA-protein cysteine methyltransferase YP_001345189.1 PFAM: membrane protein involved in aromatic hydrocarbon degradation; KEGG: hso:HS_1548 outer membrane protein P1 YP_001345190.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001345191.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001345192.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001345193.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001345194.1 PFAM: Rod shape-determining protein MreD; KEGG: msu:MS0593 rod shape-determining protein YP_001345195.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001345196.1 functions in MreBCD complex in some organisms YP_001345197.1 TIGRFAM: molybdopterin guanine dinucleotide-containing S/N-oxide reductase; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: msu:MS0588 anaerobic dehydrogenases, typically selenocysteine-containing YP_001345198.1 KEGG: hdu:HD1393 cytochrome c-type protein TorY YP_001345199.1 PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: msu:MS0588 anaerobic dehydrogenases, typically selenocysteine-containing YP_001345200.1 TIGRFAM: translation initiation factor IF-1; PFAM: RNA binding S1 domain protein; S1 IF1 family protein; KEGG: hso:HS_0705 translation initiation factor IF-1 YP_001345201.1 Transfers the fatty acyl group on membrane lipoproteins YP_001345202.1 PFAM: CBS domain containing protein; transporter-associated region; KEGG: pmu:PM1033 hemolysin, putative YP_001345203.1 TIGRFAM: alkylphosphonate utilization operon protein PhnA; PFAM: PhnA protein; KEGG: msu:MS0619 uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism YP_001345204.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: msu:MS0696 hypothetical protein YP_001345205.1 PFAM: Tripartite ATP-independent periplasmic transporter DctQ component; KEGG: msu:MS0697 hypothetical protein YP_001345206.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit; KEGG: msu:MS0698 DctP protein YP_001345207.1 TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; KEGG: hin:HI1145 chorismate mutase (CM) / prephenate dehydratase (PDT) (P-protein) YP_001345208.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_001345209.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001345210.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001345211.1 PFAM: cell division protein FtsA; KEGG: msu:MS1662 predicted ATPases of the HSP70 class involved in cell division YP_001345212.1 PFAM: cell division protein FtsQ; Polypeptide-transport-associated domain protein FtsQ-type; KEGG: msu:MS1663 cell division septal protein YP_001345213.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001345214.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001345215.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001345216.1 TIGRFAM: cell division protein FtsW; PFAM: cell cycle protein; KEGG: msu:MS1668 bacterial cell division membrane protein YP_001345217.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001345218.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001345219.1 TIGRFAM: UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: msu:MS1671 UDP-N-acetylmuramyl pentapeptide synthase YP_001345220.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001345221.1 PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; KEGG: msu:MS1673 cell division protein FtsI/penicillin-binding protein 2 YP_001345222.1 PFAM: cell division protein FtsL; KEGG: msu:MS1674 cell division protein YP_001345223.1 TIGRFAM: S-adenosyl-methyltransferase MraW; PFAM: methyltransferase; KEGG: msu:MS1675 predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis YP_001345224.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001345225.1 PFAM: carbon starvation protein CstA; KEGG: msu:MS1677 CstA protein YP_001345226.1 KEGG: msu:MS1678 hypothetical protein YP_001345227.1 PFAM: GCN5-related N-acetyltransferase; protein of unknown function DUF699 ATPase putative; KEGG: msu:MS1679 hypothetical protein YP_001345228.1 PFAM: protein of unknown function UPF0054; KEGG: msu:MS1680 predicted metal-dependent hydrolase YP_001345229.1 PFAM: PhoH family protein; KEGG: msu:MS1682 phosphate starvation-inducible protein PhoH, predicted ATPase YP_001345230.1 Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine YP_001345231.1 PFAM: extracellular solute-binding protein family 3; KEGG: msu:MS1684 ABC-type amino acid transport system, periplasmic component YP_001345232.1 PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: msu:MS1685 ABC-type polar amino acid transport system, ATPase component YP_001345233.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS1686 ABC-type amino acid transport system, permease component YP_001345234.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: msu:MS1687 ABC-type amino acid transport system, permease component YP_001345235.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001345236.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_001345237.1 PFAM: dihydrodipicolinate synthetase; KEGG: msu:MS0067 DapA protein YP_001345238.1 PFAM: iron-containing alcohol dehydrogenase; KEGG: msu:MS0069 EutG protein YP_001345239.1 TIGRFAM: TRAP transporter solute receptor, TAXI family; KEGG: maq:Maqu_2063 TRAP transporter solute receptor, TAXI family YP_001345240.1 TIGRFAM: TRAP transporter, 4TM/12TM fusion protein; PFAM: Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: sfu:Sfum_3721 TRAP transporter, 4TM/12TM fusion protein YP_001345241.1 PFAM: Na+ symporter; KEGG: eca:ECA3764 probable sodium:solute symporter YP_001345242.1 PFAM: glycosyl hydrolase BNR repeat-containing protein; KEGG: eca:ECA3765 hypothetical protein YP_001345243.1 PFAM: conserved hypothetical protein 22; KEGG: eca:ECA3766 hypothetical protein YP_001345244.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001345245.1 PFAM: outer membrane chaperone Skp (OmpH); KEGG: msu:MS1923 outer membrane protein YP_001345246.1 PFAM: surface antigen (D15); surface antigen variable number repeat protein; KEGG: msu:MS1924 predicted outer membrane protein YP_001345247.1 TIGRFAM: putative membrane-associated zinc metalloprotease; PFAM: PDZ/DHR/GLGF domain protein; peptidase M50; KEGG: msu:MS1925 predicted membrane-associated Zn-dependent proteases 1 YP_001345248.1 PFAM: phosphatidate cytidylyltransferase; KEGG: msu:MS1926 CDP-diglyceride synthetase YP_001345249.1 TIGRFAM: undecaprenyl diphosphate synthase; PFAM: Di-trans-poly-cis-decaprenylcistransferase; KEGG: msu:MS1927 undecaprenyl pyrophosphate synthase YP_001345250.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001345251.1 PFAM: protein of unknown function DUF484; KEGG: msu:MS1785 hypothetical protein YP_001345252.1 TIGRFAM: L-lactate transport; PFAM: L-lactate permease; KEGG: msu:MS0753 L-lactate permease YP_001345253.1 PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: hdu:HD1221 conserved putative dehydrogenase subunit YP_001345254.1 TIGRFAM: iron-sulfur cluster binding protein; PFAM: protein of unknown function DUF162; KEGG: hdu:HD1220 putative iron-sulfur electron transport protein YP_001345255.1 PFAM: protein of unknown function DUF162; KEGG: msu:MS0750 hypothetical protein YP_001345256.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001345257.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: pmu:PM1700 hypothetical S. marcescens YP_001345258.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001345259.1 PFAM: protein of unknown function DUF167; KEGG: msu:MS0322 hypothetical protein YP_001345260.1 PFAM: protein of unknown function YGGT; KEGG: msu:MS0321 hypothetical protein YP_001345261.1 responsible for the influx of magnesium ions YP_001345262.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: msu:MS0181 NADH dehydrogenase, FAD-containing subunit YP_001345263.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_001345264.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001345265.1 PFAM: protein of unknown function DUF416; KEGG: msu:MS0184 hypothetical protein YP_001345266.1 PFAM: histone family protein DNA-binding protein; KEGG: msu:MS0185 HimA protein YP_001345267.1 catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position YP_001345268.1 PFAM: glycosyl transferase family 9; KEGG: hin:HI0261 lipopolysaccharide biosynthesis protein YP_001345269.1 PFAM: pseudouridine synthase; KEGG: msu:MS0231 pseudouridylate synthases, 23S RNA-specific YP_001345270.1 TIGRFAM: TRAP transporter solute receptor, TAXI family; KEGG: msu:MS0331 predicted periplasmic binding protein YP_001345271.1 PFAM: UspA domain protein; KEGG: msu:MS0329 UspA protein YP_001345272.1 TIGRFAM: TRAP transporter, 4TM/12TM fusion protein; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: msu:MS0330 hypothetical protein YP_001345273.1 TIGRFAM: TRAP transporter solute receptor, TAXI family; KEGG: msu:MS0331 predicted periplasmic binding protein YP_001345274.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_001345275.1 TIGRFAM: nicotinamide mononucleotide transporter PnuC; PFAM: Nicotinamide mononucleotide transporter PnuC; KEGG: msu:MS0193 PnuC protein YP_001345276.1 PFAM: protein of unknown function DUF204; KEGG: msu:MS0192 hypothetical protein YP_001345277.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_001345278.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: msu:MS2235 predicted hydrolases of the HAD superfamily YP_001345279.1 KEGG: fnu:FN0616 hypothetical protein YP_001345280.1 TIGRFAM: anaerobic c4-dicarboxylate antiporter, Dcu family; PFAM: anaerobic c4-dicarboxylate membrane transporter; Citrate transporter; KEGG: cff:CFF8240_0146 anaerobic C4-dicarboxylate membrane transporter YP_001345281.1 carries the fatty acid chain in fatty acid biosynthesis YP_001345282.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001345283.1 TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: msu:MS1873 (acyl-carrier-protein) S-malonyltransferase YP_001345284.1 TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) synthase III; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: hit:NTHI0247 3-oxoacyl-[acyl-carrier-protein] synthase III YP_001345285.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001345286.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001345287.1 PFAM: protein of unknown function DUF177; KEGG: msu:MS1868 predicted metal-binding, possibly nucleic acid-binding protein YP_001345288.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_001345289.1 PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase substrate binding; KEGG: msu:MS0248 rRNA methylases YP_001345290.1 PFAM: protein of unknown function DUF554; KEGG: msu:MS0512 uncharacterized membrane protein, possible Na+ channel or PumP YP_001345291.1 TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: msu:MS0513 periplasmic protein TonB, links inner and outer membranes YP_001345292.1 TIGRFAM: TonB system transport protein ExbD type-2; PFAM: Biopolymer transport protein ExbD/TolR; KEGG: msu:MS0514 biopolymer transport protein YP_001345293.1 TIGRFAM: TonB-system energizer ExbB type-2; PFAM: MotA/TolQ/ExbB proton channel; KEGG: msu:MS0515 TolQ protein YP_001345294.1 TIGRFAM: putative metalloendopeptidase, glycoprotease family; PFAM: peptidase M22 glycoprotease; KEGG: msu:MS1763 metal-dependent proteases with possible chaperone activity YP_001345295.1 PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: msu:MS1783 ATPases with chaperone activity, ATP-binding subunit YP_001345296.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001345297.1 PFAM: protein of unknown function zinc metallopeptidase putative; KEGG: msu:MS1854 predicted metalloprotease YP_001345298.1 TIGRFAM: exsB protein; PFAM: ExsB family protein; KEGG: msu:MS1855 predicted ATPase (PP-loop superfamily), confers aluminum resistance YP_001345299.1 PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: msu:MS1856 6-pyruvoyl-tetrahydropterin synthase YP_001345300.1 PFAM: Radical SAM domain protein; KEGG: pmu:PM0184 hypothetical HI1189 YP_001345301.1 TIGRFAM: mutator MutT protein; PFAM: NUDIX hydrolase; KEGG: msu:MS0328 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_001345302.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001345303.1 KEGG: msu:MS0326 hypothetical protein YP_001345304.1 KEGG: msu:MS0325 hypothetical protein YP_001345305.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_001345306.1 KEGG: msu:MS1921 hypothetical protein YP_001345307.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001345308.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001345309.1 SMART: helix-turn-helix domain protein; KEGG: msu:MS1918 hypothetical protein YP_001345310.1 TIGRFAM: type IV pilus biogenesis/stability protein PilW; PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: msu:MS1917 uncharacterized protein involved in fimbrial biogenesis YP_001345311.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001345312.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001345313.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001345314.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_001345315.1 TIGRFAM: periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; PFAM: NapC/NirT cytochrome c domain protein; KEGG: msu:MS2277 nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit YP_001345316.1 PFAM: Nitrate reductase cytochrome c-type subunit (NapB); KEGG: msu:MS2278 nitrate reductase cytochrome c-type subunit YP_001345317.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_001345318.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_001345319.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_001345320.1 PFAM: NapD family protein; KEGG: hdu:HD0073 possible napD protein YP_001345321.1 TIGRFAM: ferredoxin-type protein NapF; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: msu:MS2283 ferredoxin 2 YP_001345322.1 PFAM: Patatin; KEGG: hdu:HD0066 hypothetical protein YP_001345323.1 KEGG: msu:MS1961 hypothetical protein YP_001345324.1 PFAM: protein of unknown function DUF331; KEGG: pmu:PM1129 hypothetical HI0235 YP_001345325.1 PFAM: protein of unknown function UPF0118; KEGG: msu:MS1958 predicted permease YP_001345326.1 KEGG: msu:MS0259 hypothetical protein YP_001345327.1 PFAM: NUDIX hydrolase; KEGG: msu:MS0258 MutT protein YP_001345328.1 KEGG: hso:HS_0622 hypothetical protein YP_001345329.1 KEGG: hso:HS_0621 hypothetical protein YP_001345330.1 KEGG: csa:Csal_2566 conserved hypothetical protein; putative conserved domain YP_001345331.1 PFAM: helix-turn-helix domain protein; KEGG: plu:plu0778 MrfJ protein YP_001345332.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001345333.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001345334.1 catalyzes the modification of U13 in tRNA(Glu) YP_001345335.1 PFAM: Di-haem cytochrome c peroxidase; KEGG: msu:MS0223 cytochrome c peroxidase YP_001345336.1 PFAM: regulatory protein MerR; Transcription regulator MerR DNA binding; KEGG: msu:MS0179 SoxR protein YP_001345337.1 PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: msu:MS0499 ProP protein YP_001345338.1 TIGRFAM: conserved hypothetical integral membrane protein; PFAM: protein of unknown function DUF165; KEGG: pmu:PM1889 hypothetical HI0862 YP_001345339.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_001345340.1 PFAM: helicase domain protein; DbpA RNA-binding domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: msu:MS0495 superfamily II DNA and RNA helicases YP_001345341.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_001345342.1 PFAM: 3' exoribonuclease; RNA binding S1 domain protein; KH type 1 domain protein; SMART: KH domain protein; KEGG: msu:MS0493 polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) YP_001345343.1 PFAM: conserved hypothetical protein 22; KEGG: pmu:PM1713 hypothetical HI0227 YP_001345344.1 KEGG: msu:MS0473 exoribonucleases; TIGRFAM: VacB and RNase II family 3'-5' exoribonuclease; ribonuclease R; PFAM: ribonuclease II; RNA binding S1 domain protein; Ribonuclease B OB region domain; Ribonuclease R winged-helix domain protein; SMART: Cold shock protein YP_001345345.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_001345346.1 PFAM: thymidine kinase; KEGG: msu:MS1764 thymidine kinase YP_001345347.1 PFAM: Entericidin EcnAB; KEGG: msu:MS1765 hypothetical protein YP_001345348.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001345349.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_001345350.1 putative role in sulfur assimilation YP_001345351.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_001345352.1 TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: phospholipid/glycerol acyltransferase; KEGG: pmu:PM0103 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_001345353.1 PFAM: multicopper oxidase type 3; KEGG: msu:MS0511 putative multicopper oxidases YP_001345354.1 PFAM: Carboxymuconolactone decarboxylase; KEGG: msu:MS0180 uncharacterized ACR, similar to gamma-carboxymuconolactone decarboxylase subunit YP_001345355.1 KEGG: vei:Veis_1858 serine/threonine-protein kinase YP_001345356.1 PFAM: O-methyltransferase domain protein; KEGG: pmu:PM1322 tetracenomycin C synthesis protein YP_001345357.1 KEGG: cth:Cthe_3139 hypothetical protein YP_001345358.1 PFAM: phospholipase/Carboxylesterase; KEGG: ilo:IL0037 phospholipase/carboxylesterase family protein YP_001345359.1 PFAM: DSBA oxidoreductase; KEGG: msu:MS2007 FrnE protein YP_001345360.1 PFAM: helix-turn-helix HxlR type; KEGG: fnu:FN1232 transcriptional regulator, MarR family YP_001345361.1 KEGG: tde:TDE0358 cinnamoyl ester hydrolase YP_001345362.1 KEGG: pfl:PFL_5952 PhlG YP_001345363.1 PFAM: regulatory protein TetR; KEGG: msu:MS1300 AcrR protein YP_001345364.1 KEGG: msu:MS1396 hypothetical protein YP_001345365.1 KEGG: ppe:PEPE_1799 hypothetical protein YP_001345366.1 KEGG: msu:MS1397 hypothetical protein YP_001345367.1 PFAM: NAD-dependent epimerase/dehydratase; NmrA family protein; KEGG: msu:MS1405 hypothetical protein YP_001345368.1 KEGG: sus:Acid_2913 hypothetical protein YP_001345369.1 PFAM: aldo/keto reductase; KEGG: yen:YE0342 putative aldo/keto reductase YP_001345370.1 PFAM: aldo/keto reductase; KEGG: tma:TM1009 oxidoreductase, aldo/keto reductase family YP_001345371.1 KEGG: mhu:Mhun_1407 hypothetical protein YP_001345372.1 KEGG: pmu:PM1936 unknown YP_001345373.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001345374.1 PFAM: Carboxylesterase type B; KEGG: rle:pRL110316 putative exported carboxylesterase YP_001345375.1 PFAM: aldo/keto reductase; KEGG: ade:Adeh_3215 aldo/keto reductase YP_001345376.1 PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: msu:MS1210 LysR protein YP_001345377.1 PFAM: GCN5-related N-acetyltransferase; KEGG: rpa:RPA2988 GCN5-related N-acetyltransferase YP_001345378.1 PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: rfr:Rfer_2439 alcohol dehydrogenase, zinc-binding YP_001345379.1 KEGG: tde:TDE0802 hypothetical protein YP_001345380.1 PFAM: protein of unknown function DUF1486; KEGG: bce:BC0915 hypothetical protein YP_001345382.1 PFAM: Cupin 2 conserved barrel domain protein; KEGG: ctc:CTC00439 hypothetical protein YP_001345383.1 KEGG: msu:MS0505 hypothetical protein YP_001345384.1 PFAM: Opacity-associated protein A; Opacity-associated protein A domain protein; KEGG: msu:MS0506 cell envelope opacity-associated protein A YP_001345385.1 TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein; KEGG: msu:MS0507 KamA protein YP_001345386.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001345387.1 TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: msu:MS1770 cysteine synthase YP_001345388.1 TIGRFAM: integral membrane protein MviN; PFAM: virulence factor MVIN family protein; KEGG: msu:MS1755 uncharacterized membrane protein, putative virulence factor YP_001345389.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001345390.1 KEGG: msu:MS1757 membrane protein YP_001345391.1 catalyzes the formation of serine from O-phosphoserine YP_001345392.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_001345393.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001345394.1 PFAM: protein of unknown function DUF37; KEGG: pmu:PM1164 hypothetical HI1000 YP_001345395.1 TIGRFAM: ribonuclease P protein component; PFAM: ribonuclease P protein; KEGG: msu:MS0483 RNase P protein component YP_001345396.1 in Escherichia coli transcription of this gene is enhanced by polyamines