-- dump date   	20140618_190222
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
509173000001	Initiator Replication protein; Region: Rep_3; pfam01051
509173000002	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
509173000003	Sel1-like repeats; Region: SEL1; smart00671
509173000004	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
509173000005	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
509173000006	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
509173000007	MobA/MobL family; Region: MobA_MobL; pfam03389
509173000008	Initiator Replication protein; Region: Rep_3; pfam01051
509173000009	Helix-turn-helix domain; Region: HTH_17; cl17695
509173000010	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
509173000011	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
509173000012	catalytic Zn binding site [ion binding]; other site
509173000013	structural Zn binding site [ion binding]; other site
509173000014	NAD(P) binding site [chemical binding]; other site
509173000015	Protein of unknown function (DUF497); Region: DUF497; pfam04365
509173000016	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
509173000017	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
509173000018	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
509173000019	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
509173000020	oligomer interface [polypeptide binding]; other site
509173000021	Replication protein; Region: Rep_1; cl02412
509173000022	Initiator Replication protein; Region: Rep_3; pfam01051
509173000023	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; transposase
509173000024	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; transposase of ISAba5
509173000025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173000026	Walker A/P-loop; other site
509173000027	ATP binding site [chemical binding]; other site
509173000028	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
509173000029	Q-loop/lid; other site
509173000030	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173000031	ABC transporter signature motif; other site
509173000032	Walker B; other site
509173000033	D-loop; other site
509173000034	H-loop/switch region; other site
509173000035	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173000036	Walker A/P-loop; other site
509173000037	ATP binding site [chemical binding]; other site
509173000038	Q-loop/lid; other site
509173000039	ABC transporter signature motif; other site
509173000040	Walker B; other site
509173000041	D-loop; other site
509173000042	H-loop/switch region; other site
509173000043	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; transposase
509173000044	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme; transposase of ISAba5 element
509173000045	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
509173000046	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
509173000047	NADP binding site [chemical binding]; other site
509173000048	dimer interface [polypeptide binding]; other site
509173000049	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
509173000050	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173000051	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
509173000052	integrase; Provisional; Region: PRK09692
509173000053	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
509173000054	active site
509173000055	Int/Topo IB signature motif; other site
509173000056	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
509173000057	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
509173000058	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
509173000059	putative C-terminal domain interface [polypeptide binding]; other site
509173000060	putative GSH binding site (G-site) [chemical binding]; other site
509173000061	putative dimer interface [polypeptide binding]; other site
509173000062	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
509173000063	N-terminal domain interface [polypeptide binding]; other site
509173000064	dimer interface [polypeptide binding]; other site
509173000065	substrate binding pocket (H-site) [chemical binding]; other site
509173000066	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
509173000067	Prostaglandin dehydrogenases; Region: PGDH; cd05288
509173000068	NAD(P) binding site [chemical binding]; other site
509173000069	substrate binding site [chemical binding]; other site
509173000070	dimer interface [polypeptide binding]; other site
509173000071	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173000072	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173000073	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
509173000074	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
509173000075	FMN binding site [chemical binding]; other site
509173000076	active site
509173000077	substrate binding site [chemical binding]; other site
509173000078	catalytic residue [active]
509173000079	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
509173000080	intracellular protease, PfpI family; Region: PfpI; TIGR01382
509173000081	potential catalytic triad [active]
509173000082	conserved cys residue [active]
509173000083	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
509173000084	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
509173000085	dimer interface [polypeptide binding]; other site
509173000086	active site
509173000087	metal binding site [ion binding]; metal-binding site
509173000088	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase, IS3 family
509173000089	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
509173000090	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
509173000091	S-formylglutathione hydrolase; Region: PLN02442
509173000092	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
509173000093	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
509173000094	substrate binding site [chemical binding]; other site
509173000095	catalytic Zn binding site [ion binding]; other site
509173000096	NAD binding site [chemical binding]; other site
509173000097	structural Zn binding site [ion binding]; other site
509173000098	dimer interface [polypeptide binding]; other site
509173000099	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
509173000100	putative homodimer interface [polypeptide binding]; other site
509173000101	putative homotetramer interface [polypeptide binding]; other site
509173000102	putative metal binding site [ion binding]; other site
509173000103	putative homodimer-homodimer interface [polypeptide binding]; other site
509173000104	putative allosteric switch controlling residues; other site
509173000105	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase, IS3 family (part 1)
509173000106	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase, IS3 family (part 2)
509173000107	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
509173000108	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
509173000109	conserved cys residue [active]
509173000110	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173000111	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173000112	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
509173000113	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
509173000114	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
509173000115	active site
509173000116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173000117	metabolite-proton symporter; Region: 2A0106; TIGR00883
509173000118	putative substrate translocation pore; other site
509173000119	aromatic amino acid exporter; Provisional; Region: PRK11689
509173000120	EamA-like transporter family; Region: EamA; pfam00892
509173000121	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase, IS5 family (part 1)
509173000122	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase, IS5 family (part 2)
509173000123	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase, IS5 family (part 3)
509173000124	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
509173000125	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
509173000126	putative NAD(P) binding site [chemical binding]; other site
509173000127	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
509173000128	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
509173000129	putative NAD(P) binding site [chemical binding]; other site
509173000130	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173000131	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173000132	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
509173000133	putative effector binding pocket; other site
509173000134	dimerization interface [polypeptide binding]; other site
509173000135	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
509173000136	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173000137	NAD(P) binding site [chemical binding]; other site
509173000138	active site
509173000139	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
509173000140	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
509173000141	putative NAD(P) binding site [chemical binding]; other site
509173000142	dimer interface [polypeptide binding]; other site
509173000143	Uncharacterized conserved protein [Function unknown]; Region: COG1359
509173000144	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase, IS3 family
509173000145	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
509173000146	Sel1-like repeats; Region: SEL1; smart00671
509173000147	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
509173000148	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
509173000149	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
509173000150	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
509173000151	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173000152	non-specific DNA binding site [nucleotide binding]; other site
509173000153	salt bridge; other site
509173000154	sequence-specific DNA binding site [nucleotide binding]; other site
509173000155	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173000156	non-specific DNA binding site [nucleotide binding]; other site
509173000157	salt bridge; other site
509173000158	sequence-specific DNA binding site [nucleotide binding]; other site
509173000159	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
509173000160	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase, IS3 family
509173000161	Evidence 7 : Gene remnant; putative prevent-host-death protein
509173000162	AAA ATPase domain; Region: AAA_15; pfam13175
509173000163	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173000164	Walker A/P-loop; other site
509173000165	ATP binding site [chemical binding]; other site
509173000166	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
509173000167	ATP binding site [chemical binding]; other site
509173000168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173000169	Walker B; other site
509173000170	D-loop; other site
509173000171	H-loop/switch region; other site
509173000172	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase (part 2)
509173000173	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of transposase (part 1)
509173000174	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
509173000175	Transposase; Region: HTH_Tnp_1; pfam01527
509173000176	Adenosine deaminase z-alpha domain; Region: z-alpha; cl02659
509173000177	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
509173000178	ATP binding site [chemical binding]; other site
509173000179	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
509173000180	AAA domain; Region: AAA_12; pfam13087
509173000181	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
509173000182	putative active site [active]
509173000183	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
509173000184	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
509173000185	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
509173000186	TIGR02687 family protein; Region: TIGR02687
509173000187	PglZ domain; Region: PglZ; pfam08665
509173000188	Protein of unknown function (DUF2408); Region: DUF2408; pfam10303
509173000189	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
509173000190	Methyltransferase domain; Region: Methyltransf_26; pfam13659
509173000191	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
509173000192	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
509173000193	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
509173000194	Predicted transcriptional regulator [Transcription]; Region: COG2378
509173000195	WYL domain; Region: WYL; pfam13280
509173000196	Evidence 5 : No homology to any previously reported sequences; hypothetical protein (part 1)
509173000197	Evidence 5 : No homology to any previously reported sequences; hypothetical protein (part 2)
509173000198	Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of putative cell filamentation-like protein
509173000199	enoyl-CoA hydratase; Validated; Region: PRK08788
509173000200	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
509173000201	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173000202	Phage-related protein, tail component [Function unknown]; Region: COG4733
509173000203	BRO family, N-terminal domain; Region: Bro-N; smart01040
509173000204	Bacteriophage lambda tail assembly protein I; Region: Lambda_tail_I; cl01945
509173000205	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
509173000206	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
509173000207	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173000208	salt bridge; other site
509173000209	non-specific DNA binding site [nucleotide binding]; other site
509173000210	sequence-specific DNA binding site [nucleotide binding]; other site
509173000211	hypothetical protein; Provisional; Region: PRK10040
509173000212	Terminase-like family; Region: Terminase_6; pfam03237
509173000213	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2)
509173000214	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1)
509173000215	hypothetical protein; Provisional; Region: PRK09741
509173000216	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
509173000217	active site
509173000218	catalytic residues [active]
509173000219	DNA binding site [nucleotide binding]
509173000220	Int/Topo IB signature motif; other site
509173000221	Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of putative cell filamentation-like protein (part 1)
509173000222	Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of putative cell filamentation-like protein (part 2)
509173000223	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173000224	non-specific DNA binding site [nucleotide binding]; other site
509173000225	salt bridge; other site
509173000226	sequence-specific DNA binding site [nucleotide binding]; other site
509173000227	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1)
509173000228	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2)
509173000229	Evidence 7 : Gene remnant; Product type pe : putative enzyme; fragment of putative alkaline phosphatase
509173000230	ParB-like nuclease domain; Region: ParB; smart00470
509173000231	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
509173000232	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
509173000233	P-loop; other site
509173000234	Magnesium ion binding site [ion binding]; other site
509173000235	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
509173000236	Magnesium ion binding site [ion binding]; other site
509173000237	DnaA N-terminal domain; Region: DnaA_N; pfam11638
509173000238	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
509173000239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173000240	Walker A motif; other site
509173000241	ATP binding site [chemical binding]; other site
509173000242	Walker B motif; other site
509173000243	arginine finger; other site
509173000244	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
509173000245	DnaA box-binding interface [nucleotide binding]; other site
509173000246	DNA polymerase III subunit beta; Validated; Region: PRK05643
509173000247	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
509173000248	putative DNA binding surface [nucleotide binding]; other site
509173000249	dimer interface [polypeptide binding]; other site
509173000250	beta-clamp/clamp loader binding surface; other site
509173000251	beta-clamp/translesion DNA polymerase binding surface; other site
509173000252	recombination protein F; Reviewed; Region: recF; PRK00064
509173000253	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173000254	Walker A/P-loop; other site
509173000255	ATP binding site [chemical binding]; other site
509173000256	Q-loop/lid; other site
509173000257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173000258	ABC transporter signature motif; other site
509173000259	Walker B; other site
509173000260	D-loop; other site
509173000261	H-loop/switch region; other site
509173000262	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
509173000263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173000264	ATP binding site [chemical binding]; other site
509173000265	Mg2+ binding site [ion binding]; other site
509173000266	G-X-G motif; other site
509173000267	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
509173000268	anchoring element; other site
509173000269	dimer interface [polypeptide binding]; other site
509173000270	ATP binding site [chemical binding]; other site
509173000271	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
509173000272	active site
509173000273	putative metal-binding site [ion binding]; other site
509173000274	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
509173000275	Cytochrome b562; Region: Cytochrom_B562; pfam07361
509173000276	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
509173000277	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
509173000278	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
509173000279	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
509173000280	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
509173000281	ABC transporter; Region: ABC_tran_2; pfam12848
509173000282	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
509173000283	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
509173000284	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
509173000285	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
509173000286	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173000287	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
509173000288	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
509173000289	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
509173000290	active site
509173000291	HIGH motif; other site
509173000292	dimer interface [polypeptide binding]; other site
509173000293	KMSKS motif; other site
509173000294	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
509173000295	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
509173000296	putative C-terminal domain interface [polypeptide binding]; other site
509173000297	putative GSH binding site (G-site) [chemical binding]; other site
509173000298	putative dimer interface [polypeptide binding]; other site
509173000299	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
509173000300	dimer interface [polypeptide binding]; other site
509173000301	N-terminal domain interface [polypeptide binding]; other site
509173000302	substrate binding pocket (H-site) [chemical binding]; other site
509173000303	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
509173000304	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
509173000305	Na2 binding site [ion binding]; other site
509173000306	putative substrate binding site 1 [chemical binding]; other site
509173000307	Na binding site 1 [ion binding]; other site
509173000308	putative substrate binding site 2 [chemical binding]; other site
509173000309	16S rRNA methyltransferase B; Provisional; Region: PRK10901
509173000310	NusB family; Region: NusB; pfam01029
509173000311	putative RNA binding site [nucleotide binding]; other site
509173000312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173000313	S-adenosylmethionine binding site [chemical binding]; other site
509173000314	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
509173000315	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
509173000316	putative active site [active]
509173000317	substrate binding site [chemical binding]; other site
509173000318	putative cosubstrate binding site; other site
509173000319	catalytic site [active]
509173000320	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
509173000321	substrate binding site [chemical binding]; other site
509173000322	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
509173000323	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
509173000324	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173000325	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173000326	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173000327	dimerization interface [polypeptide binding]; other site
509173000328	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
509173000329	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
509173000330	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
509173000331	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173000332	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173000333	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
509173000334	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
509173000335	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173000336	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
509173000337	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
509173000338	chaperone protein DnaJ; Provisional; Region: PRK10767
509173000339	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
509173000340	HSP70 interaction site [polypeptide binding]; other site
509173000341	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
509173000342	substrate binding site [polypeptide binding]; other site
509173000343	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
509173000344	Zn binding sites [ion binding]; other site
509173000345	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
509173000346	dimer interface [polypeptide binding]; other site
509173000347	ribonuclease E; Reviewed; Region: rne; PRK10811
509173000348	dihydrodipicolinate reductase; Provisional; Region: PRK00048
509173000349	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
509173000350	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
509173000351	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
509173000352	putative lipid binding site [chemical binding]; other site
509173000353	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
509173000354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173000355	putative substrate translocation pore; other site
509173000356	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
509173000357	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
509173000358	active site
509173000359	catalytic tetrad [active]
509173000360	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173000361	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173000362	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
509173000363	putative effector binding pocket; other site
509173000364	dimerization interface [polypeptide binding]; other site
509173000365	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
509173000366	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173000367	DNA-binding site [nucleotide binding]; DNA binding site
509173000368	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173000369	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173000370	homodimer interface [polypeptide binding]; other site
509173000371	catalytic residue [active]
509173000372	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
509173000373	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
509173000374	putative NAD(P) binding site [chemical binding]; other site
509173000375	putative substrate binding site [chemical binding]; other site
509173000376	catalytic Zn binding site [ion binding]; other site
509173000377	structural Zn binding site [ion binding]; other site
509173000378	dimer interface [polypeptide binding]; other site
509173000379	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
509173000380	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
509173000381	Peptidase family M23; Region: Peptidase_M23; pfam01551
509173000382	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
509173000383	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
509173000384	minor groove reading motif; other site
509173000385	helix-hairpin-helix signature motif; other site
509173000386	substrate binding pocket [chemical binding]; other site
509173000387	active site
509173000388	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
509173000389	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
509173000390	DNA binding and oxoG recognition site [nucleotide binding]
509173000391	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
509173000392	nucleotide binding site/active site [active]
509173000393	HIT family signature motif; other site
509173000394	catalytic residue [active]
509173000395	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
509173000396	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
509173000397	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
509173000398	hypothetical protein; Provisional; Region: PRK05170
509173000399	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
509173000400	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
509173000401	recombination factor protein RarA; Reviewed; Region: PRK13342
509173000402	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173000403	Walker A motif; other site
509173000404	ATP binding site [chemical binding]; other site
509173000405	Walker B motif; other site
509173000406	arginine finger; other site
509173000407	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
509173000408	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
509173000409	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
509173000410	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
509173000411	ATP binding site [chemical binding]; other site
509173000412	active site
509173000413	substrate binding site [chemical binding]; other site
509173000414	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
509173000415	dihydrodipicolinate synthase; Region: dapA; TIGR00674
509173000416	dimer interface [polypeptide binding]; other site
509173000417	active site
509173000418	catalytic residue [active]
509173000419	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
509173000420	Isochorismatase family; Region: Isochorismatase; pfam00857
509173000421	catalytic triad [active]
509173000422	metal binding site [ion binding]; metal-binding site
509173000423	conserved cis-peptide bond; other site
509173000424	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
509173000425	Sodium Bile acid symporter family; Region: SBF; pfam01758
509173000426	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
509173000427	putative efflux protein, MATE family; Region: matE; TIGR00797
509173000428	cation binding site [ion binding]; other site
509173000429	Uncharacterized conserved protein [Function unknown]; Region: COG1683
509173000430	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
509173000431	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
509173000432	dimer interface [polypeptide binding]; other site
509173000433	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
509173000434	active site
509173000435	Fe binding site [ion binding]; other site
509173000436	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
509173000437	Transcriptional regulator [Transcription]; Region: IclR; COG1414
509173000438	Bacterial transcriptional regulator; Region: IclR; pfam01614
509173000439	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
509173000440	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
509173000441	Zn binding site [ion binding]; other site
509173000442	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
509173000443	maleylacetoacetate isomerase; Region: maiA; TIGR01262
509173000444	C-terminal domain interface [polypeptide binding]; other site
509173000445	GSH binding site (G-site) [chemical binding]; other site
509173000446	putative dimer interface [polypeptide binding]; other site
509173000447	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
509173000448	dimer interface [polypeptide binding]; other site
509173000449	N-terminal domain interface [polypeptide binding]; other site
509173000450	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
509173000451	fumarylacetoacetase; Region: PLN02856
509173000452	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
509173000453	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
509173000454	aromatic amino acid transporter; Provisional; Region: PRK10238
509173000455	Peptidase M15; Region: Peptidase_M15_3; cl01194
509173000456	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
509173000457	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
509173000458	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
509173000459	Acyltransferase family; Region: Acyl_transf_3; pfam01757
509173000460	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
509173000461	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173000462	DNA-binding site [nucleotide binding]; DNA binding site
509173000463	UTRA domain; Region: UTRA; pfam07702
509173000464	HutD; Region: HutD; pfam05962
509173000465	urocanate hydratase; Provisional; Region: PRK05414
509173000466	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
509173000467	active sites [active]
509173000468	tetramer interface [polypeptide binding]; other site
509173000469	putative proline-specific permease; Provisional; Region: proY; PRK10580
509173000470	imidazolonepropionase; Validated; Region: PRK09356
509173000471	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
509173000472	active site
509173000473	agmatinase; Region: agmatinase; TIGR01230
509173000474	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
509173000475	putative active site [active]
509173000476	putative metal binding site [ion binding]; other site
509173000477	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
509173000478	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
509173000479	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173000480	motif II; other site
509173000481	glutamate racemase; Provisional; Region: PRK00865
509173000482	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
509173000483	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
509173000484	cofactor binding site; other site
509173000485	DNA binding site [nucleotide binding]
509173000486	substrate interaction site [chemical binding]; other site
509173000487	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
509173000488	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
509173000489	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173000490	ATP binding site [chemical binding]; other site
509173000491	Mg2+ binding site [ion binding]; other site
509173000492	G-X-G motif; other site
509173000493	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
509173000494	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
509173000495	glutaminase active site [active]
509173000496	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
509173000497	dimer interface [polypeptide binding]; other site
509173000498	active site
509173000499	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
509173000500	dimer interface [polypeptide binding]; other site
509173000501	active site
509173000502	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
509173000503	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
509173000504	Substrate binding site; other site
509173000505	Mg++ binding site; other site
509173000506	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
509173000507	active site
509173000508	substrate binding site [chemical binding]; other site
509173000509	CoA binding site [chemical binding]; other site
509173000510	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
509173000511	tetramer interfaces [polypeptide binding]; other site
509173000512	binuclear metal-binding site [ion binding]; other site
509173000513	thiamine monophosphate kinase; Provisional; Region: PRK05731
509173000514	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
509173000515	ATP binding site [chemical binding]; other site
509173000516	dimerization interface [polypeptide binding]; other site
509173000517	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
509173000518	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
509173000519	homopentamer interface [polypeptide binding]; other site
509173000520	active site
509173000521	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
509173000522	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
509173000523	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
509173000524	dimerization interface [polypeptide binding]; other site
509173000525	active site
509173000526	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
509173000527	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
509173000528	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
509173000529	phosphoserine phosphatase SerB; Region: serB; TIGR00338
509173000530	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173000531	motif II; other site
509173000532	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
509173000533	putative active site [active]
509173000534	dimerization interface [polypeptide binding]; other site
509173000535	putative tRNAtyr binding site [nucleotide binding]; other site
509173000536	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
509173000537	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
509173000538	active site
509173000539	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
509173000540	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
509173000541	active site residue [active]
509173000542	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
509173000543	active site residue [active]
509173000544	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
509173000545	Secretory lipase; Region: LIP; pfam03583
509173000546	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
509173000547	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
509173000548	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
509173000549	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
509173000550	putative active site [active]
509173000551	heme pocket [chemical binding]; other site
509173000552	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173000553	dimer interface [polypeptide binding]; other site
509173000554	phosphorylation site [posttranslational modification]
509173000555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173000556	ATP binding site [chemical binding]; other site
509173000557	Mg2+ binding site [ion binding]; other site
509173000558	G-X-G motif; other site
509173000559	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
509173000560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173000561	active site
509173000562	phosphorylation site [posttranslational modification]
509173000563	intermolecular recognition site; other site
509173000564	dimerization interface [polypeptide binding]; other site
509173000565	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173000566	DNA binding site [nucleotide binding]
509173000567	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173000568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173000569	short chain dehydrogenase; Provisional; Region: PRK07832
509173000570	NAD(P) binding site [chemical binding]; other site
509173000571	active site
509173000572	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
509173000573	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
509173000574	methionine aminotransferase; Validated; Region: PRK09082
509173000575	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173000576	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173000577	homodimer interface [polypeptide binding]; other site
509173000578	catalytic residue [active]
509173000579	Protein of unknown function (DUF445); Region: DUF445; pfam04286
509173000580	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
509173000581	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
509173000582	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
509173000583	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
509173000584	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
509173000585	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
509173000586	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
509173000587	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
509173000588	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173000589	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
509173000590	Bacterial SH3 domain; Region: SH3_3; cl17532
509173000591	PGAP1-like protein; Region: PGAP1; pfam07819
509173000592	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
509173000593	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
509173000594	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
509173000595	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
509173000596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173000597	ATP binding site [chemical binding]; other site
509173000598	Mg2+ binding site [ion binding]; other site
509173000599	G-X-G motif; other site
509173000600	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
509173000601	anchoring element; other site
509173000602	dimer interface [polypeptide binding]; other site
509173000603	ATP binding site [chemical binding]; other site
509173000604	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
509173000605	active site
509173000606	metal binding site [ion binding]; metal-binding site
509173000607	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
509173000608	ureidoglycolate hydrolase; Provisional; Region: PRK03606
509173000609	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
509173000610	allantoicase; Region: allantoicase; TIGR02961
509173000611	Allantoicase repeat; Region: Allantoicase; pfam03561
509173000612	Allantoicase repeat; Region: Allantoicase; pfam03561
509173000613	hypothetical protein; Provisional; Region: PRK07236
509173000614	FAD binding domain; Region: FAD_binding_3; pfam01494
509173000615	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114
509173000616	xanthine permease; Region: pbuX; TIGR03173
509173000617	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
509173000618	active site
509173000619	homotetramer interface [polypeptide binding]; other site
509173000620	putative OHCU decarboxylase; Provisional; Region: PRK13798
509173000621	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
509173000622	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
509173000623	active site
509173000624	catalytic site [active]
509173000625	tetramer interface [polypeptide binding]; other site
509173000626	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
509173000627	30S subunit binding site; other site
509173000628	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
509173000629	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
509173000630	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
509173000631	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
509173000632	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
509173000633	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
509173000634	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
509173000635	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
509173000636	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
509173000637	metal binding site [ion binding]; metal-binding site
509173000638	active site
509173000639	I-site; other site
509173000640	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
509173000641	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
509173000642	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
509173000643	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
509173000644	ArsC family; Region: ArsC; pfam03960
509173000645	putative catalytic residues [active]
509173000646	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
509173000647	putative active site [active]
509173000648	putative catalytic site [active]
509173000649	putative DNA binding site [nucleotide binding]; other site
509173000650	putative phosphate binding site [ion binding]; other site
509173000651	metal binding site A [ion binding]; metal-binding site
509173000652	putative AP binding site [nucleotide binding]; other site
509173000653	putative metal binding site B [ion binding]; other site
509173000654	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
509173000655	active site
509173000656	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
509173000657	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173000658	N-terminal plug; other site
509173000659	ligand-binding site [chemical binding]; other site
509173000660	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
509173000661	glutathione synthetase; Provisional; Region: PRK05246
509173000662	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
509173000663	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
509173000664	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
509173000665	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
509173000666	active site
509173000667	homodimer interface [polypeptide binding]; other site
509173000668	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
509173000669	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
509173000670	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
509173000671	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
509173000672	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
509173000673	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
509173000674	ATP-grasp domain; Region: ATP-grasp_4; cl17255
509173000675	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
509173000676	Cell division protein FtsQ; Region: FtsQ; pfam03799
509173000677	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
509173000678	Cell division protein FtsA; Region: FtsA; smart00842
509173000679	Cell division protein FtsA; Region: FtsA; pfam14450
509173000680	cell division protein FtsZ; Validated; Region: PRK09330
509173000681	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
509173000682	nucleotide binding site [chemical binding]; other site
509173000683	SulA interaction site; other site
509173000684	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
509173000685	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
509173000686	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
509173000687	Peptidase family M23; Region: Peptidase_M23; pfam01551
509173000688	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
509173000689	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
509173000690	dimer interface [polypeptide binding]; other site
509173000691	TPP-binding site [chemical binding]; other site
509173000692	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
509173000693	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
509173000694	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
509173000695	E3 interaction surface; other site
509173000696	lipoyl attachment site [posttranslational modification]; other site
509173000697	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
509173000698	E3 interaction surface; other site
509173000699	lipoyl attachment site [posttranslational modification]; other site
509173000700	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
509173000701	E3 interaction surface; other site
509173000702	lipoyl attachment site [posttranslational modification]; other site
509173000703	e3 binding domain; Region: E3_binding; pfam02817
509173000704	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
509173000705	Predicted membrane protein [Function unknown]; Region: COG2119
509173000706	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
509173000707	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
509173000708	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc :  receptor; fragment of ferric siderophore receptor protein (part 2)
509173000709	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc :  receptor; fragment of ferric siderophore receptor protein (part 1)
509173000710	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
509173000711	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
509173000712	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
509173000713	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
509173000714	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
509173000715	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
509173000716	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
509173000717	active site
509173000718	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
509173000719	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
509173000720	active site
509173000721	substrate binding site [chemical binding]; other site
509173000722	metal binding site [ion binding]; metal-binding site
509173000723	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
509173000724	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
509173000725	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
509173000726	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
509173000727	DHH family; Region: DHH; pfam01368
509173000728	DHHA1 domain; Region: DHHA1; pfam02272
509173000729	peptide chain release factor 2; Provisional; Region: PRK08787
509173000730	This domain is found in peptide chain release factors; Region: PCRF; smart00937
509173000731	RF-1 domain; Region: RF-1; pfam00472
509173000732	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173000733	putative DNA binding site [nucleotide binding]; other site
509173000734	dimerization interface [polypeptide binding]; other site
509173000735	putative Zn2+ binding site [ion binding]; other site
509173000736	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
509173000737	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
509173000738	FMN binding site [chemical binding]; other site
509173000739	active site
509173000740	substrate binding site [chemical binding]; other site
509173000741	catalytic residue [active]
509173000742	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
509173000743	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
509173000744	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
509173000745	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
509173000746	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
509173000747	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
509173000748	Mechanosensitive ion channel; Region: MS_channel; pfam00924
509173000749	Protein of unknown function (DUF805); Region: DUF805; pfam05656
509173000750	acetyl-CoA synthetase; Provisional; Region: PRK00174
509173000751	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
509173000752	active site
509173000753	CoA binding site [chemical binding]; other site
509173000754	acyl-activating enzyme (AAE) consensus motif; other site
509173000755	AMP binding site [chemical binding]; other site
509173000756	acetate binding site [chemical binding]; other site
509173000757	Isochorismatase family; Region: Isochorismatase; pfam00857
509173000758	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
509173000759	catalytic triad [active]
509173000760	conserved cis-peptide bond; other site
509173000761	Peroxidase, family 2; Region: Peroxidase_2; pfam01328
509173000762	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
509173000763	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
509173000764	dimerization interface [polypeptide binding]; other site
509173000765	putative DNA binding site [nucleotide binding]; other site
509173000766	putative Zn2+ binding site [ion binding]; other site
509173000767	AsnC family; Region: AsnC_trans_reg; pfam01037
509173000768	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
509173000769	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
509173000770	active site
509173000771	dimer interface [polypeptide binding]; other site
509173000772	non-prolyl cis peptide bond; other site
509173000773	insertion regions; other site
509173000774	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
509173000775	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
509173000776	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
509173000777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173000778	active site
509173000779	phosphorylation site [posttranslational modification]
509173000780	intermolecular recognition site; other site
509173000781	dimerization interface [polypeptide binding]; other site
509173000782	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
509173000783	DNA binding residues [nucleotide binding]
509173000784	dimerization interface [polypeptide binding]; other site
509173000785	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
509173000786	Na binding site [ion binding]; other site
509173000787	PAS fold; Region: PAS_7; pfam12860
509173000788	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
509173000789	putative active site [active]
509173000790	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
509173000791	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173000792	dimer interface [polypeptide binding]; other site
509173000793	phosphorylation site [posttranslational modification]
509173000794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173000795	ATP binding site [chemical binding]; other site
509173000796	Mg2+ binding site [ion binding]; other site
509173000797	G-X-G motif; other site
509173000798	Response regulator receiver domain; Region: Response_reg; pfam00072
509173000799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173000800	active site
509173000801	phosphorylation site [posttranslational modification]
509173000802	intermolecular recognition site; other site
509173000803	dimerization interface [polypeptide binding]; other site
509173000804	Protein of unknown function, DUF485; Region: DUF485; pfam04341
509173000805	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
509173000806	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
509173000807	Na binding site [ion binding]; other site
509173000808	BCCT family transporter; Region: BCCT; pfam02028
509173000809	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173000810	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
509173000811	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
509173000812	metal binding site [ion binding]; metal-binding site
509173000813	active site
509173000814	I-site; other site
509173000815	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
509173000816	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
509173000817	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
509173000818	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
509173000819	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173000820	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173000821	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
509173000822	2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292
509173000823	putative NAD(P) binding site [chemical binding]; other site
509173000824	putative dimer interface [polypeptide binding]; other site
509173000825	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
509173000826	GlpM protein; Region: GlpM; pfam06942
509173000827	Putative transcription activator [Transcription]; Region: TenA; COG0819
509173000828	hypothetical protein; Provisional; Region: PRK14013
509173000829	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173000830	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173000831	putative substrate translocation pore; other site
509173000832	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
509173000833	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
509173000834	dimer interface [polypeptide binding]; other site
509173000835	ssDNA binding site [nucleotide binding]; other site
509173000836	tetramer (dimer of dimers) interface [polypeptide binding]; other site
509173000837	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
509173000838	AzlC protein; Region: AzlC; cl00570
509173000839	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
509173000840	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173000841	non-specific DNA binding site [nucleotide binding]; other site
509173000842	salt bridge; other site
509173000843	sequence-specific DNA binding site [nucleotide binding]; other site
509173000844	Cupin domain; Region: Cupin_2; pfam07883
509173000845	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
509173000846	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
509173000847	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173000848	DNA-binding site [nucleotide binding]; DNA binding site
509173000849	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173000850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173000851	homodimer interface [polypeptide binding]; other site
509173000852	catalytic residue [active]
509173000853	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
509173000854	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
509173000855	inhibitor-cofactor binding pocket; inhibition site
509173000856	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173000857	catalytic residue [active]
509173000858	succinic semialdehyde dehydrogenase; Region: PLN02278
509173000859	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
509173000860	tetramerization interface [polypeptide binding]; other site
509173000861	NAD(P) binding site [chemical binding]; other site
509173000862	catalytic residues [active]
509173000863	LysR family transcriptional regulator; Provisional; Region: PRK14997
509173000864	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173000865	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173000866	dimerization interface [polypeptide binding]; other site
509173000867	Isochorismatase family; Region: Isochorismatase; pfam00857
509173000868	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
509173000869	catalytic triad [active]
509173000870	dimer interface [polypeptide binding]; other site
509173000871	conserved cis-peptide bond; other site
509173000872	Pirin-related protein [General function prediction only]; Region: COG1741
509173000873	Pirin; Region: Pirin; pfam02678
509173000874	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
509173000875	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
509173000876	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
509173000877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173000878	S-adenosylmethionine binding site [chemical binding]; other site
509173000879	Uncharacterized conserved protein [Function unknown]; Region: COG3791
509173000880	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173000881	putative substrate translocation pore; other site
509173000882	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173000883	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173000884	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
509173000885	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173000886	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
509173000887	putative dimerization interface [polypeptide binding]; other site
509173000888	putative substrate binding pocket [chemical binding]; other site
509173000889	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
509173000890	EamA-like transporter family; Region: EamA; pfam00892
509173000891	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
509173000892	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
509173000893	active site
509173000894	catalytic tetrad [active]
509173000895	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173000896	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173000897	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173000898	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173000899	Uncharacterized conserved protein [Function unknown]; Region: COG2128
509173000900	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
509173000901	Predicted transcriptional regulators [Transcription]; Region: COG1733
509173000902	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
509173000903	Predicted transcriptional regulators [Transcription]; Region: COG1733
509173000904	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
509173000905	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
509173000906	Helix-turn-helix domain; Region: HTH_18; pfam12833
509173000907	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173000908	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
509173000909	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
509173000910	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
509173000911	potassium uptake protein; Region: kup; TIGR00794
509173000912	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
509173000913	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
509173000914	active site
509173000915	substrate binding site [chemical binding]; other site
509173000916	Mg2+ binding site [ion binding]; other site
509173000917	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173000918	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
509173000919	amphipathic channel; other site
509173000920	Asn-Pro-Ala signature motifs; other site
509173000921	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173000922	Helix-turn-helix domain; Region: HTH_18; pfam12833
509173000923	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173000924	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
509173000925	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
509173000926	substrate binding site [chemical binding]; other site
509173000927	glutamase interaction surface [polypeptide binding]; other site
509173000928	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
509173000929	Phosphotransferase enzyme family; Region: APH; pfam01636
509173000930	putative active site [active]
509173000931	putative substrate binding site [chemical binding]; other site
509173000932	ATP binding site [chemical binding]; other site
509173000933	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
509173000934	DNA-binding site [nucleotide binding]; DNA binding site
509173000935	RNA-binding motif; other site
509173000936	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
509173000937	Predicted membrane protein [Function unknown]; Region: COG3671
509173000938	EamA-like transporter family; Region: EamA; pfam00892
509173000939	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
509173000940	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
509173000941	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173000942	non-specific DNA binding site [nucleotide binding]; other site
509173000943	salt bridge; other site
509173000944	sequence-specific DNA binding site [nucleotide binding]; other site
509173000945	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
509173000946	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
509173000947	catalytic residues [active]
509173000948	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
509173000949	catalytic site [active]
509173000950	putative active site [active]
509173000951	putative substrate binding site [chemical binding]; other site
509173000952	Protein of unknown function (DUF805); Region: DUF805; pfam05656
509173000953	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
509173000954	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
509173000955	putative active site [active]
509173000956	oxyanion strand; other site
509173000957	catalytic triad [active]
509173000958	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
509173000959	putative active site pocket [active]
509173000960	4-fold oligomerization interface [polypeptide binding]; other site
509173000961	metal binding residues [ion binding]; metal-binding site
509173000962	3-fold/trimer interface [polypeptide binding]; other site
509173000963	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173000964	Coenzyme A binding pocket [chemical binding]; other site
509173000965	putative acetyltransferase; Provisional; Region: PRK03624
509173000966	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173000967	Coenzyme A binding pocket [chemical binding]; other site
509173000968	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
509173000969	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
509173000970	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
509173000971	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
509173000972	HAMP domain; Region: HAMP; pfam00672
509173000973	dimerization interface [polypeptide binding]; other site
509173000974	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173000975	dimer interface [polypeptide binding]; other site
509173000976	phosphorylation site [posttranslational modification]
509173000977	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173000978	ATP binding site [chemical binding]; other site
509173000979	Mg2+ binding site [ion binding]; other site
509173000980	G-X-G motif; other site
509173000981	osmolarity response regulator; Provisional; Region: ompR; PRK09468
509173000982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173000983	active site
509173000984	phosphorylation site [posttranslational modification]
509173000985	intermolecular recognition site; other site
509173000986	dimerization interface [polypeptide binding]; other site
509173000987	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173000988	DNA binding site [nucleotide binding]
509173000989	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
509173000990	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
509173000991	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
509173000992	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
509173000993	RNA binding site [nucleotide binding]; other site
509173000994	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
509173000995	Sulfate transporter family; Region: Sulfate_transp; pfam00916
509173000996	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
509173000997	active site clefts [active]
509173000998	zinc binding site [ion binding]; other site
509173000999	dimer interface [polypeptide binding]; other site
509173001000	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
509173001001	classical (c) SDRs; Region: SDR_c; cd05233
509173001002	NAD(P) binding site [chemical binding]; other site
509173001003	active site
509173001004	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
509173001005	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
509173001006	homodimer interface [polypeptide binding]; other site
509173001007	substrate-cofactor binding pocket; other site
509173001008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173001009	catalytic residue [active]
509173001010	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
509173001011	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
509173001012	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
509173001013	ABC transporter; Region: ABC_tran_2; pfam12848
509173001014	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
509173001015	hypothetical protein; Provisional; Region: PRK10215
509173001016	Outer membrane efflux protein; Region: OEP; pfam02321
509173001017	Outer membrane efflux protein; Region: OEP; pfam02321
509173001018	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173001019	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
509173001020	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173001021	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
509173001022	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
509173001023	S-methylmethionine transporter; Provisional; Region: PRK11387
509173001024	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
509173001025	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
509173001026	active site
509173001027	HIGH motif; other site
509173001028	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
509173001029	active site
509173001030	KMSKS motif; other site
509173001031	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
509173001032	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
509173001033	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
509173001034	MraW methylase family; Region: Methyltransf_5; cl17771
509173001035	Cell division protein FtsL; Region: FtsL; pfam04999
509173001036	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
509173001037	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
509173001038	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
509173001039	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
509173001040	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
509173001041	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
509173001042	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
509173001043	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
509173001044	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
509173001045	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
509173001046	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
509173001047	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
509173001048	Mg++ binding site [ion binding]; other site
509173001049	putative catalytic motif [active]
509173001050	putative substrate binding site [chemical binding]; other site
509173001051	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
509173001052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173001053	S-adenosylmethionine binding site [chemical binding]; other site
509173001054	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
509173001055	Transglycosylase; Region: Transgly; pfam00912
509173001056	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
509173001057	Competence protein A; Region: Competence_A; pfam11104
509173001058	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
509173001059	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
509173001060	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
509173001061	Pilus assembly protein, PilO; Region: PilO; pfam04350
509173001062	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
509173001063	Pilus assembly protein, PilP; Region: PilP; pfam04351
509173001064	AMIN domain; Region: AMIN; pfam11741
509173001065	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
509173001066	Secretin and TonB N terminus short domain; Region: STN; smart00965
509173001067	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
509173001068	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
509173001069	shikimate kinase; Reviewed; Region: aroK; PRK00131
509173001070	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
509173001071	ADP binding site [chemical binding]; other site
509173001072	magnesium binding site [ion binding]; other site
509173001073	putative shikimate binding site; other site
509173001074	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
509173001075	active site
509173001076	dimer interface [polypeptide binding]; other site
509173001077	metal binding site [ion binding]; metal-binding site
509173001078	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
509173001079	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
509173001080	active site
509173001081	dimer interface [polypeptide binding]; other site
509173001082	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
509173001083	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
509173001084	active site
509173001085	FMN binding site [chemical binding]; other site
509173001086	substrate binding site [chemical binding]; other site
509173001087	3Fe-4S cluster binding site [ion binding]; other site
509173001088	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
509173001089	domain interface; other site
509173001090	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
509173001091	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
509173001092	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173001093	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
509173001094	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
509173001095	LemA family; Region: LemA; pfam04011
509173001096	Repair protein; Region: Repair_PSII; pfam04536
509173001097	Repair protein; Region: Repair_PSII; pfam04536
509173001098	Pilin (bacterial filament); Region: Pilin; pfam00114
509173001099	O-Antigen ligase; Region: Wzy_C; pfam04932
509173001100	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
509173001101	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
509173001102	heme binding site [chemical binding]; other site
509173001103	Ferritin-like domain; Region: Ferritin; pfam00210
509173001104	ferroxidase pore; other site
509173001105	ferroxidase diiron center [ion binding]; other site
509173001106	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
509173001107	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
509173001108	homotrimer interaction site [polypeptide binding]; other site
509173001109	putative active site [active]
509173001110	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
509173001111	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
509173001112	Zn2+ binding site [ion binding]; other site
509173001113	Mg2+ binding site [ion binding]; other site
509173001114	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
509173001115	synthetase active site [active]
509173001116	NTP binding site [chemical binding]; other site
509173001117	metal binding site [ion binding]; metal-binding site
509173001118	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
509173001119	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
509173001120	ACT domain; Region: ACT_4; pfam13291
509173001121	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
509173001122	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
509173001123	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
509173001124	catalytic site [active]
509173001125	G-X2-G-X-G-K; other site
509173001126	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
509173001127	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
509173001128	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
509173001129	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
509173001130	von Willebrand factor type A domain; Region: VWA_2; pfam13519
509173001131	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
509173001132	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
509173001133	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
509173001134	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
509173001135	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
509173001136	RimM N-terminal domain; Region: RimM; pfam01782
509173001137	PRC-barrel domain; Region: PRC; pfam05239
509173001138	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
509173001139	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
509173001140	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
509173001141	Putative serine esterase (DUF676); Region: DUF676; pfam05057
509173001142	lipase chaperone; Provisional; Region: PRK01294
509173001143	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
509173001144	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
509173001145	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
509173001146	RNA binding site [nucleotide binding]; other site
509173001147	active site
509173001148	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
509173001149	hypothetical protein; Provisional; Region: PRK10621
509173001150	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
509173001151	Hemerythrin-like domain; Region: Hr-like; cd12108
509173001152	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
509173001153	threonine and homoserine efflux system; Provisional; Region: PRK10532
509173001154	EamA-like transporter family; Region: EamA; pfam00892
509173001155	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
509173001156	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
509173001157	ligand binding site [chemical binding]; other site
509173001158	NAD binding site [chemical binding]; other site
509173001159	tetramer interface [polypeptide binding]; other site
509173001160	catalytic site [active]
509173001161	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
509173001162	L-serine binding site [chemical binding]; other site
509173001163	ACT domain interface; other site
509173001164	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
509173001165	FAD binding domain; Region: FAD_binding_4; pfam01565
509173001166	Uncharacterized conserved protein [Function unknown]; Region: COG1359
509173001167	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
509173001168	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
509173001169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173001170	putative substrate translocation pore; other site
509173001171	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
509173001172	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
509173001173	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
509173001174	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
509173001175	E-class dimer interface [polypeptide binding]; other site
509173001176	P-class dimer interface [polypeptide binding]; other site
509173001177	active site
509173001178	Cu2+ binding site [ion binding]; other site
509173001179	Zn2+ binding site [ion binding]; other site
509173001180	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
509173001181	Domain of unknown function DUF20; Region: UPF0118; pfam01594
509173001182	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
509173001183	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
509173001184	P-loop; other site
509173001185	Magnesium ion binding site [ion binding]; other site
509173001186	Endonuclease related to archaeal Holliday junction resolvase; Region: Endonuc_Holl; cl01958
509173001187	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
509173001188	Methyltransferase domain; Region: Methyltransf_23; pfam13489
509173001189	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173001190	S-adenosylmethionine binding site [chemical binding]; other site
509173001191	S-methylmethionine transporter; Provisional; Region: PRK11387
509173001192	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
509173001193	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
509173001194	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
509173001195	NAD(P) binding site [chemical binding]; other site
509173001196	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
509173001197	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
509173001198	inhibitor-cofactor binding pocket; inhibition site
509173001199	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173001200	catalytic residue [active]
509173001201	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
509173001202	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
509173001203	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
509173001204	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
509173001205	NAD(P) binding site [chemical binding]; other site
509173001206	catalytic residues [active]
509173001207	succinylarginine dihydrolase; Provisional; Region: PRK13281
509173001208	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
509173001209	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
509173001210	putative active site [active]
509173001211	Zn binding site [ion binding]; other site
509173001212	hypothetical protein; Provisional; Region: PRK12472
509173001213	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
509173001214	active site
509173001215	catalytic residues [active]
509173001216	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173001217	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173001218	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173001219	dimerization interface [polypeptide binding]; other site
509173001220	EamA-like transporter family; Region: EamA; pfam00892
509173001221	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
509173001222	EamA-like transporter family; Region: EamA; pfam00892
509173001223	YCII-related domain; Region: YCII; cl00999
509173001224	Protein of unknown function DUF262; Region: DUF262; pfam03235
509173001225	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
509173001226	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
509173001227	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
509173001228	dimer interface [polypeptide binding]; other site
509173001229	motif 1; other site
509173001230	active site
509173001231	motif 2; other site
509173001232	motif 3; other site
509173001233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173001234	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173001235	putative substrate translocation pore; other site
509173001236	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
509173001237	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173001238	FeS/SAM binding site; other site
509173001239	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
509173001240	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
509173001241	HPP family; Region: HPP; pfam04982
509173001242	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
509173001243	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
509173001244	PspC domain; Region: PspC; pfam04024
509173001245	hypothetical protein; Provisional; Region: PRK11615
509173001246	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
509173001247	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
509173001248	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173001249	active site
509173001250	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
509173001251	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
509173001252	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
509173001253	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
509173001254	shikimate binding site; other site
509173001255	NAD(P) binding site [chemical binding]; other site
509173001256	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
509173001257	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
509173001258	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
509173001259	dimerization interface [polypeptide binding]; other site
509173001260	active site
509173001261	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
509173001262	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
509173001263	TPP-binding site; other site
509173001264	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
509173001265	PYR/PP interface [polypeptide binding]; other site
509173001266	dimer interface [polypeptide binding]; other site
509173001267	TPP binding site [chemical binding]; other site
509173001268	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
509173001269	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
509173001270	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
509173001271	active site
509173001272	dimerization interface [polypeptide binding]; other site
509173001273	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
509173001274	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
509173001275	ATP binding site [chemical binding]; other site
509173001276	Mg++ binding site [ion binding]; other site
509173001277	motif III; other site
509173001278	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
509173001279	nucleotide binding region [chemical binding]; other site
509173001280	ATP-binding site [chemical binding]; other site
509173001281	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
509173001282	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
509173001283	Walker A/P-loop; other site
509173001284	ATP binding site [chemical binding]; other site
509173001285	Q-loop/lid; other site
509173001286	ABC transporter signature motif; other site
509173001287	Walker B; other site
509173001288	D-loop; other site
509173001289	H-loop/switch region; other site
509173001290	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
509173001291	Permease; Region: Permease; cl00510
509173001292	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
509173001293	mce related protein; Region: MCE; pfam02470
509173001294	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
509173001295	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
509173001296	anti sigma factor interaction site; other site
509173001297	regulatory phosphorylation site [posttranslational modification]; other site
509173001298	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
509173001299	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
509173001300	Cl binding site [ion binding]; other site
509173001301	oligomer interface [polypeptide binding]; other site
509173001302	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
509173001303	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
509173001304	nudix motif; other site
509173001305	comF family protein; Region: comF; TIGR00201
509173001306	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
509173001307	active site
509173001308	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
509173001309	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
509173001310	ssDNA binding site; other site
509173001311	generic binding surface II; other site
509173001312	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
509173001313	ATP binding site [chemical binding]; other site
509173001314	putative Mg++ binding site [ion binding]; other site
509173001315	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
509173001316	nucleotide binding region [chemical binding]; other site
509173001317	ATP-binding site [chemical binding]; other site
509173001318	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173001319	NADH(P)-binding; Region: NAD_binding_10; pfam13460
509173001320	NAD(P) binding site [chemical binding]; other site
509173001321	active site
509173001322	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
509173001323	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
509173001324	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
509173001325	putative acyl-acceptor binding pocket; other site
509173001326	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
509173001327	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
509173001328	active site
509173001329	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
509173001330	catalytic triad [active]
509173001331	dimer interface [polypeptide binding]; other site
509173001332	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
509173001333	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
509173001334	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
509173001335	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
509173001336	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
509173001337	G1 box; other site
509173001338	GTP/Mg2+ binding site [chemical binding]; other site
509173001339	Switch I region; other site
509173001340	G2 box; other site
509173001341	G3 box; other site
509173001342	Switch II region; other site
509173001343	G4 box; other site
509173001344	G5 box; other site
509173001345	Transcriptional regulator; Region: Rrf2; cl17282
509173001346	Rrf2 family protein; Region: rrf2_super; TIGR00738
509173001347	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
509173001348	heme-binding site [chemical binding]; other site
509173001349	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
509173001350	FAD binding pocket [chemical binding]; other site
509173001351	conserved FAD binding motif [chemical binding]; other site
509173001352	phosphate binding motif [ion binding]; other site
509173001353	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
509173001354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173001355	Walker A motif; other site
509173001356	ATP binding site [chemical binding]; other site
509173001357	Walker B motif; other site
509173001358	Zonular occludens toxin (Zot); Region: Zot; cl17485
509173001359	cystathionine beta-lyase; Provisional; Region: PRK07050
509173001360	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
509173001361	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
509173001362	catalytic residue [active]
509173001363	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
509173001364	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
509173001365	catalytic triad [active]
509173001366	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
509173001367	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
509173001368	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
509173001369	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
509173001370	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
509173001371	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
509173001372	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
509173001373	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
509173001374	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
509173001375	putative translocon binding site; other site
509173001376	protein-rRNA interface [nucleotide binding]; other site
509173001377	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
509173001378	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
509173001379	G-X-X-G motif; other site
509173001380	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
509173001381	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
509173001382	23S rRNA interface [nucleotide binding]; other site
509173001383	5S rRNA interface [nucleotide binding]; other site
509173001384	putative antibiotic binding site [chemical binding]; other site
509173001385	L25 interface [polypeptide binding]; other site
509173001386	L27 interface [polypeptide binding]; other site
509173001387	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
509173001388	23S rRNA interface [nucleotide binding]; other site
509173001389	putative translocon interaction site; other site
509173001390	signal recognition particle (SRP54) interaction site; other site
509173001391	L23 interface [polypeptide binding]; other site
509173001392	trigger factor interaction site; other site
509173001393	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
509173001394	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
509173001395	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
509173001396	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
509173001397	RNA binding site [nucleotide binding]; other site
509173001398	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
509173001399	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
509173001400	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
509173001401	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
509173001402	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
509173001403	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
509173001404	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
509173001405	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
509173001406	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
509173001407	5S rRNA interface [nucleotide binding]; other site
509173001408	23S rRNA interface [nucleotide binding]; other site
509173001409	L5 interface [polypeptide binding]; other site
509173001410	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
509173001411	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
509173001412	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
509173001413	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
509173001414	23S rRNA binding site [nucleotide binding]; other site
509173001415	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
509173001416	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
509173001417	SecY translocase; Region: SecY; pfam00344
509173001418	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
509173001419	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
509173001420	30S ribosomal protein S13; Region: bact_S13; TIGR03631
509173001421	30S ribosomal protein S11; Validated; Region: PRK05309
509173001422	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
509173001423	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
509173001424	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
509173001425	RNA binding surface [nucleotide binding]; other site
509173001426	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
509173001427	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
509173001428	alphaNTD homodimer interface [polypeptide binding]; other site
509173001429	alphaNTD - beta interaction site [polypeptide binding]; other site
509173001430	alphaNTD - beta' interaction site [polypeptide binding]; other site
509173001431	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
509173001432	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
509173001433	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
509173001434	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
509173001435	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173001436	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173001437	active site
509173001438	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
509173001439	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
509173001440	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
509173001441	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
509173001442	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
509173001443	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
509173001444	active site
509173001445	Zn binding site [ion binding]; other site
509173001446	ribonuclease R; Region: RNase_R; TIGR02063
509173001447	RNB domain; Region: RNB; pfam00773
509173001448	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
509173001449	RNA binding site [nucleotide binding]; other site
509173001450	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
509173001451	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
509173001452	dimer interface [polypeptide binding]; other site
509173001453	FMN binding site [chemical binding]; other site
509173001454	YcxB-like protein; Region: YcxB; pfam14317
509173001455	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
509173001456	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
509173001457	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
509173001458	Helix-turn-helix domain; Region: HTH_18; pfam12833
509173001459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173001460	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
509173001461	EamA-like transporter family; Region: EamA; pfam00892
509173001462	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
509173001463	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
509173001464	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
509173001465	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
509173001466	active site
509173001467	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
509173001468	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
509173001469	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
509173001470	metal-binding heat shock protein; Provisional; Region: PRK00016
509173001471	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
509173001472	PhoH-like protein; Region: PhoH; pfam02562
509173001473	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
509173001474	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
509173001475	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173001476	FeS/SAM binding site; other site
509173001477	TRAM domain; Region: TRAM; cl01282
509173001478	lytic murein transglycosylase; Provisional; Region: PRK11619
509173001479	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
509173001480	N-acetyl-D-glucosamine binding site [chemical binding]; other site
509173001481	catalytic residue [active]
509173001482	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
509173001483	B1 nucleotide binding pocket [chemical binding]; other site
509173001484	B2 nucleotide binding pocket [chemical binding]; other site
509173001485	CAS motifs; other site
509173001486	active site
509173001487	malate dehydrogenase; Provisional; Region: PRK05442
509173001488	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
509173001489	NAD(P) binding site [chemical binding]; other site
509173001490	dimer interface [polypeptide binding]; other site
509173001491	malate binding site [chemical binding]; other site
509173001492	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
509173001493	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
509173001494	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
509173001495	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
509173001496	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
509173001497	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
509173001498	Uncharacterized conserved protein [Function unknown]; Region: COG3791
509173001499	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
509173001500	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173001501	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173001502	active site
509173001503	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173001504	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173001505	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
509173001506	RUN domain; Region: RUN; cl02689
509173001507	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
509173001508	NAD(P) binding site [chemical binding]; other site
509173001509	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
509173001510	substrate binding site [chemical binding]; other site
509173001511	homotetramer interface [polypeptide binding]; other site
509173001512	active site
509173001513	homodimer interface [polypeptide binding]; other site
509173001514	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
509173001515	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
509173001516	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
509173001517	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173001518	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173001519	active site
509173001520	enoyl-CoA hydratase; Provisional; Region: PRK05995
509173001521	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173001522	substrate binding site [chemical binding]; other site
509173001523	oxyanion hole (OAH) forming residues; other site
509173001524	trimer interface [polypeptide binding]; other site
509173001525	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
509173001526	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
509173001527	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
509173001528	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
509173001529	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
509173001530	carboxyltransferase (CT) interaction site; other site
509173001531	biotinylation site [posttranslational modification]; other site
509173001532	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
509173001533	stringent starvation protein A; Provisional; Region: sspA; PRK09481
509173001534	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
509173001535	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
509173001536	dimer interface [polypeptide binding]; other site
509173001537	N-terminal domain interface [polypeptide binding]; other site
509173001538	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
509173001539	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
509173001540	23S rRNA interface [nucleotide binding]; other site
509173001541	L3 interface [polypeptide binding]; other site
509173001542	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
509173001543	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
509173001544	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
509173001545	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
509173001546	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
509173001547	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
509173001548	active site
509173001549	metal binding site [ion binding]; metal-binding site
509173001550	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
509173001551	LrgB-like family; Region: LrgB; cl00596
509173001552	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
509173001553	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
509173001554	HflX GTPase family; Region: HflX; cd01878
509173001555	G1 box; other site
509173001556	GTP/Mg2+ binding site [chemical binding]; other site
509173001557	Switch I region; other site
509173001558	G2 box; other site
509173001559	G3 box; other site
509173001560	Switch II region; other site
509173001561	G4 box; other site
509173001562	G5 box; other site
509173001563	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
509173001564	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
509173001565	putative acyl-acceptor binding pocket; other site
509173001566	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
509173001567	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
509173001568	putative active site [active]
509173001569	catalytic site [active]
509173001570	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
509173001571	putative active site [active]
509173001572	catalytic site [active]
509173001573	phosphodiesterase YaeI; Provisional; Region: PRK11340
509173001574	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
509173001575	putative active site [active]
509173001576	putative metal binding site [ion binding]; other site
509173001577	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
509173001578	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
509173001579	ligand binding site [chemical binding]; other site
509173001580	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
509173001581	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
509173001582	metal binding site [ion binding]; metal-binding site
509173001583	active site
509173001584	I-site; other site
509173001585	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
509173001586	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
509173001587	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173001588	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
509173001589	Putative phosphatase (DUF442); Region: DUF442; cl17385
509173001590	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1)
509173001591	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173001592	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173001593	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2)
509173001594	thioredoxin 2; Provisional; Region: PRK10996
509173001595	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
509173001596	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
509173001597	catalytic residues [active]
509173001598	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
509173001599	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
509173001600	CoenzymeA binding site [chemical binding]; other site
509173001601	subunit interaction site [polypeptide binding]; other site
509173001602	PHB binding site; other site
509173001603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
509173001604	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
509173001605	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
509173001606	active site residue [active]
509173001607	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
509173001608	Uncharacterized conserved protein [Function unknown]; Region: COG4121
509173001609	YciI-like protein; Reviewed; Region: PRK11370
509173001610	Intracellular septation protein A; Region: IspA; pfam04279
509173001611	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
509173001612	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
509173001613	active site
509173001614	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
509173001615	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
509173001616	hypothetical protein; Reviewed; Region: PRK00024
509173001617	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
509173001618	MPN+ (JAMM) motif; other site
509173001619	Zinc-binding site [ion binding]; other site
509173001620	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
509173001621	Flavoprotein; Region: Flavoprotein; pfam02441
509173001622	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
509173001623	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
509173001624	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
509173001625	Protein export membrane protein; Region: SecD_SecF; pfam02355
509173001626	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
509173001627	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
509173001628	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
509173001629	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
509173001630	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
509173001631	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
509173001632	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
509173001633	LemA family; Region: LemA; cl00742
509173001634	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
509173001635	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
509173001636	integrase; Provisional; Region: int; PHA02601
509173001637	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
509173001638	active site
509173001639	DNA binding site [nucleotide binding]
509173001640	Int/Topo IB signature motif; other site
509173001641	DNA polymerase III subunit epsilon; Validated; Region: PRK06309
509173001642	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
509173001643	active site
509173001644	catalytic site [active]
509173001645	substrate binding site [chemical binding]; other site
509173001646	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
509173001647	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
509173001648	dimer interface [polypeptide binding]; other site
509173001649	ssDNA binding site [nucleotide binding]; other site
509173001650	tetramer (dimer of dimers) interface [polypeptide binding]; other site
509173001651	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
509173001652	active site
509173001653	metal binding site [ion binding]; metal-binding site
509173001654	interdomain interaction site; other site
509173001655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173001656	non-specific DNA binding site [nucleotide binding]; other site
509173001657	salt bridge; other site
509173001658	sequence-specific DNA binding site [nucleotide binding]; other site
509173001659	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
509173001660	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
509173001661	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
509173001662	Dimer interface [polypeptide binding]; other site
509173001663	BRCT sequence motif; other site
509173001664	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
509173001665	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
509173001666	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
509173001667	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
509173001668	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
509173001669	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
509173001670	Phage tail tube protein FII; Region: Phage_tube; cl01390
509173001671	major tail sheath protein; Provisional; Region: FI; PHA02560
509173001672	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
509173001673	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
509173001674	Baseplate J-like protein; Region: Baseplate_J; cl01294
509173001675	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
509173001676	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
509173001677	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
509173001678	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
509173001679	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
509173001680	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
509173001681	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
509173001682	Protein of unknown function (DUF754); Region: DUF754; pfam05449
509173001683	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
509173001684	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
509173001685	terminase endonuclease subunit; Provisional; Region: M; PHA02537
509173001686	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
509173001687	capsid protein; Provisional; Region: N; PHA02538
509173001688	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
509173001689	terminase ATPase subunit; Provisional; Region: P; PHA02535
509173001690	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
509173001691	Phage-related protein [Function unknown]; Region: COG4695; cl01923
509173001692	Phage portal protein; Region: Phage_portal; pfam04860
509173001693	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
509173001694	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173001695	dimer interface [polypeptide binding]; other site
509173001696	phosphorylation site [posttranslational modification]
509173001697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173001698	ATP binding site [chemical binding]; other site
509173001699	Mg2+ binding site [ion binding]; other site
509173001700	G-X-G motif; other site
509173001701	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
509173001702	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
509173001703	metal binding triad; other site
509173001704	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
509173001705	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
509173001706	metal binding triad; other site
509173001707	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
509173001708	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
509173001709	homodimer interface [polypeptide binding]; other site
509173001710	substrate-cofactor binding pocket; other site
509173001711	catalytic residue [active]
509173001712	Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660
509173001713	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
509173001714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
509173001715	phosphorylation site [posttranslational modification]
509173001716	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
509173001717	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
509173001718	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
509173001719	putative active site [active]
509173001720	putative metal binding site [ion binding]; other site
509173001721	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
509173001722	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
509173001723	putative metal binding site; other site
509173001724	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
509173001725	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
509173001726	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
509173001727	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
509173001728	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
509173001729	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
509173001730	dimer interface [polypeptide binding]; other site
509173001731	anticodon binding site; other site
509173001732	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
509173001733	homodimer interface [polypeptide binding]; other site
509173001734	motif 1; other site
509173001735	active site
509173001736	motif 2; other site
509173001737	GAD domain; Region: GAD; pfam02938
509173001738	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
509173001739	active site
509173001740	motif 3; other site
509173001741	Domain of unknown function (DUF4184); Region: DUF4184; pfam13803
509173001742	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
509173001743	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173001744	N-terminal plug; other site
509173001745	ligand-binding site [chemical binding]; other site
509173001746	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
509173001747	putative active site [active]
509173001748	putative catalytic site [active]
509173001749	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
509173001750	PLD-like domain; Region: PLDc_2; pfam13091
509173001751	putative active site [active]
509173001752	putative catalytic site [active]
509173001753	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
509173001754	Predicted membrane protein [Function unknown]; Region: COG3223
509173001755	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
509173001756	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
509173001757	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173001758	active site
509173001759	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
509173001760	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
509173001761	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
509173001762	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173001763	active site
509173001764	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
509173001765	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
509173001766	dimerization interface [polypeptide binding]; other site
509173001767	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173001768	dimer interface [polypeptide binding]; other site
509173001769	phosphorylation site [posttranslational modification]
509173001770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173001771	ATP binding site [chemical binding]; other site
509173001772	Mg2+ binding site [ion binding]; other site
509173001773	G-X-G motif; other site
509173001774	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
509173001775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173001776	active site
509173001777	phosphorylation site [posttranslational modification]
509173001778	intermolecular recognition site; other site
509173001779	dimerization interface [polypeptide binding]; other site
509173001780	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173001781	DNA binding site [nucleotide binding]
509173001782	Uncharacterized conserved protein [Function unknown]; Region: COG0397
509173001783	hypothetical protein; Validated; Region: PRK00029
509173001784	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
509173001785	Di-iron ligands [ion binding]; other site
509173001786	META domain; Region: META; pfam03724
509173001787	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
509173001788	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
509173001789	active site
509173001790	catalytic site [active]
509173001791	metal binding site [ion binding]; metal-binding site
509173001792	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
509173001793	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
509173001794	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173001795	N-terminal plug; other site
509173001796	ligand-binding site [chemical binding]; other site
509173001797	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
509173001798	active site
509173001799	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
509173001800	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
509173001801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173001802	catalytic residue [active]
509173001803	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
509173001804	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
509173001805	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
509173001806	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
509173001807	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173001808	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173001809	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
509173001810	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
509173001811	substrate binding site [chemical binding]; other site
509173001812	active site
509173001813	catalytic residues [active]
509173001814	heterodimer interface [polypeptide binding]; other site
509173001815	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
509173001816	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
509173001817	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
509173001818	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
509173001819	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
509173001820	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
509173001821	active site
509173001822	catalytic residues [active]
509173001823	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
509173001824	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
509173001825	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
509173001826	dimer interface [polypeptide binding]; other site
509173001827	decamer (pentamer of dimers) interface [polypeptide binding]; other site
509173001828	catalytic triad [active]
509173001829	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
509173001830	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
509173001831	SEC-C motif; Region: SEC-C; pfam02810
509173001832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173001833	metabolite-proton symporter; Region: 2A0106; TIGR00883
509173001834	putative substrate translocation pore; other site
509173001835	Haemolysin-III related; Region: HlyIII; cl03831
509173001836	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
509173001837	Methyltransferase domain; Region: Methyltransf_31; pfam13847
509173001838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173001839	S-adenosylmethionine binding site [chemical binding]; other site
509173001840	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
509173001841	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
509173001842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173001843	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
509173001844	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
509173001845	active site
509173001846	nucleophile elbow; other site
509173001847	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
509173001848	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173001849	substrate binding site [chemical binding]; other site
509173001850	oxyanion hole (OAH) forming residues; other site
509173001851	trimer interface [polypeptide binding]; other site
509173001852	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
509173001853	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
509173001854	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
509173001855	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
509173001856	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
509173001857	dimer interface [polypeptide binding]; other site
509173001858	active site
509173001859	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173001860	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173001861	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173001862	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
509173001863	CoA-transferase family III; Region: CoA_transf_3; pfam02515
509173001864	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
509173001865	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
509173001866	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
509173001867	Trp docking motif [polypeptide binding]; other site
509173001868	putative active site [active]
509173001869	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
509173001870	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
509173001871	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
509173001872	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
509173001873	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
509173001874	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
509173001875	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
509173001876	dimer interface [polypeptide binding]; other site
509173001877	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
509173001878	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
509173001879	dimer interface [polypeptide binding]; other site
509173001880	active site
509173001881	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
509173001882	Type II transport protein GspH; Region: GspH; pfam12019
509173001883	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
509173001884	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
509173001885	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
509173001886	ligand binding site [chemical binding]; other site
509173001887	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
509173001888	hypothetical protein; Reviewed; Region: PRK09588
509173001889	lysine transporter; Provisional; Region: PRK10836
509173001890	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
509173001891	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
509173001892	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173001893	S-adenosylmethionine binding site [chemical binding]; other site
509173001894	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
509173001895	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
509173001896	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
509173001897	G1 box; other site
509173001898	putative GEF interaction site [polypeptide binding]; other site
509173001899	GTP/Mg2+ binding site [chemical binding]; other site
509173001900	Switch I region; other site
509173001901	G2 box; other site
509173001902	G3 box; other site
509173001903	Switch II region; other site
509173001904	G4 box; other site
509173001905	G5 box; other site
509173001906	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
509173001907	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
509173001908	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
509173001909	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
509173001910	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
509173001911	putative active site pocket [active]
509173001912	dimerization interface [polypeptide binding]; other site
509173001913	putative catalytic residue [active]
509173001914	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
509173001915	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
509173001916	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
509173001917	DNA binding site [nucleotide binding]
509173001918	catalytic residue [active]
509173001919	H2TH interface [polypeptide binding]; other site
509173001920	putative catalytic residues [active]
509173001921	turnover-facilitating residue; other site
509173001922	intercalation triad [nucleotide binding]; other site
509173001923	8OG recognition residue [nucleotide binding]; other site
509173001924	putative reading head residues; other site
509173001925	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
509173001926	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
509173001927	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
509173001928	active site
509173001929	DNA binding site [nucleotide binding]
509173001930	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
509173001931	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173001932	N-terminal plug; other site
509173001933	ligand-binding site [chemical binding]; other site
509173001934	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
509173001935	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
509173001936	active site
509173001937	FMN binding site [chemical binding]; other site
509173001938	substrate binding site [chemical binding]; other site
509173001939	homotetramer interface [polypeptide binding]; other site
509173001940	catalytic residue [active]
509173001941	Predicted permeases [General function prediction only]; Region: COG0679
509173001942	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
509173001943	Sel1-like repeats; Region: SEL1; smart00671
509173001944	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
509173001945	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
509173001946	dimerization domain [polypeptide binding]; other site
509173001947	dimer interface [polypeptide binding]; other site
509173001948	catalytic residues [active]
509173001949	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
509173001950	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
509173001951	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
509173001952	putative hydrophobic ligand binding site [chemical binding]; other site
509173001953	Uncharacterized conserved protein [Function unknown]; Region: COG3189
509173001954	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
509173001955	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
509173001956	PhnA protein; Region: PhnA; pfam03831
509173001957	Uncharacterized conserved protein [Function unknown]; Region: COG3422
509173001958	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
509173001959	prolyl-tRNA synthetase; Provisional; Region: PRK09194
509173001960	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
509173001961	dimer interface [polypeptide binding]; other site
509173001962	motif 1; other site
509173001963	active site
509173001964	motif 2; other site
509173001965	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
509173001966	putative deacylase active site [active]
509173001967	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
509173001968	active site
509173001969	motif 3; other site
509173001970	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
509173001971	anticodon binding site; other site
509173001972	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
509173001973	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
509173001974	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173001975	Response regulator receiver domain; Region: Response_reg; pfam00072
509173001976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173001977	active site
509173001978	phosphorylation site [posttranslational modification]
509173001979	intermolecular recognition site; other site
509173001980	dimerization interface [polypeptide binding]; other site
509173001981	Response regulator receiver domain; Region: Response_reg; pfam00072
509173001982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173001983	active site
509173001984	phosphorylation site [posttranslational modification]
509173001985	intermolecular recognition site; other site
509173001986	dimerization interface [polypeptide binding]; other site
509173001987	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
509173001988	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
509173001989	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
509173001990	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
509173001991	dimer interface [polypeptide binding]; other site
509173001992	putative CheW interface [polypeptide binding]; other site
509173001993	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
509173001994	putative binding surface; other site
509173001995	active site
509173001996	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
509173001997	putative binding surface; other site
509173001998	active site
509173001999	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
509173002000	putative binding surface; other site
509173002001	active site
509173002002	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
509173002003	putative binding surface; other site
509173002004	active site
509173002005	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
509173002006	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
509173002007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173002008	ATP binding site [chemical binding]; other site
509173002009	Mg2+ binding site [ion binding]; other site
509173002010	G-X-G motif; other site
509173002011	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
509173002012	Response regulator receiver domain; Region: Response_reg; pfam00072
509173002013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173002014	active site
509173002015	phosphorylation site [posttranslational modification]
509173002016	intermolecular recognition site; other site
509173002017	dimerization interface [polypeptide binding]; other site
509173002018	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
509173002019	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173002020	FeS/SAM binding site; other site
509173002021	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
509173002022	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
509173002023	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
509173002024	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
509173002025	metal binding site [ion binding]; metal-binding site
509173002026	dimer interface [polypeptide binding]; other site
509173002027	Predicted small secreted protein [Function unknown]; Region: COG5510
509173002028	Domain of unknown function (DUF1853); Region: DUF1853; cl01545
509173002029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
509173002030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
509173002031	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
509173002032	Uncharacterized conserved protein [Function unknown]; Region: COG1434
509173002033	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
509173002034	putative active site [active]
509173002035	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
509173002036	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
509173002037	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
509173002038	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
509173002039	Flavodoxin; Region: Flavodoxin_1; pfam00258
509173002040	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200
509173002041	FAD binding pocket [chemical binding]; other site
509173002042	FAD binding motif [chemical binding]; other site
509173002043	catalytic residues [active]
509173002044	NAD binding pocket [chemical binding]; other site
509173002045	phosphate binding motif [ion binding]; other site
509173002046	beta-alpha-beta structure motif; other site
509173002047	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
509173002048	YcxB-like protein; Region: YcxB; pfam14317
509173002049	TIGR01666 family membrane protein; Region: YCCS
509173002050	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
509173002051	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
509173002052	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
509173002053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173002054	putative substrate translocation pore; other site
509173002055	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
509173002056	putative FMN binding site [chemical binding]; other site
509173002057	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
509173002058	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
509173002059	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
509173002060	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
509173002061	active site
509173002062	nucleophile elbow; other site
509173002063	threonine dehydratase; Provisional; Region: PRK07334
509173002064	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
509173002065	tetramer interface [polypeptide binding]; other site
509173002066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173002067	catalytic residue [active]
509173002068	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
509173002069	microcin B17 transporter; Reviewed; Region: PRK11098
509173002070	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
509173002071	intracellular protease, PfpI family; Region: PfpI; TIGR01382
509173002072	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
509173002073	conserved cys residue [active]
509173002074	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
509173002075	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
509173002076	GatB domain; Region: GatB_Yqey; smart00845
509173002077	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
509173002078	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
509173002079	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
509173002080	rod shape-determining protein MreB; Provisional; Region: PRK13927
509173002081	MreB and similar proteins; Region: MreB_like; cd10225
509173002082	nucleotide binding site [chemical binding]; other site
509173002083	Mg binding site [ion binding]; other site
509173002084	putative protofilament interaction site [polypeptide binding]; other site
509173002085	RodZ interaction site [polypeptide binding]; other site
509173002086	rod shape-determining protein MreC; Provisional; Region: PRK13922
509173002087	rod shape-determining protein MreC; Region: MreC; pfam04085
509173002088	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
509173002089	Maf-like protein; Region: Maf; pfam02545
509173002090	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
509173002091	active site
509173002092	dimer interface [polypeptide binding]; other site
509173002093	ribonuclease G; Provisional; Region: PRK11712
509173002094	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
509173002095	homodimer interface [polypeptide binding]; other site
509173002096	oligonucleotide binding site [chemical binding]; other site
509173002097	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
509173002098	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
509173002099	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
509173002100	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
509173002101	Active Sites [active]
509173002102	phosphoserine phosphatase; Provisional; Region: thrH; PRK13582
509173002103	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
509173002104	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
509173002105	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
509173002106	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
509173002107	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173002108	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173002109	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173002110	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
509173002111	putative di-iron ligands [ion binding]; other site
509173002112	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
509173002113	Mrr N-terminal domain; Region: Mrr_N; pfam14338
509173002114	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
509173002115	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
509173002116	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
509173002117	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173002118	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173002119	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173002120	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
509173002121	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
509173002122	NAD(P) binding site [chemical binding]; other site
509173002123	chaperone protein HchA; Provisional; Region: PRK04155
509173002124	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
509173002125	conserved cys residue [active]
509173002126	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
509173002127	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
509173002128	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
509173002129	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
509173002130	substrate binding pocket [chemical binding]; other site
509173002131	chain length determination region; other site
509173002132	substrate-Mg2+ binding site; other site
509173002133	catalytic residues [active]
509173002134	aspartate-rich region 1; other site
509173002135	active site lid residues [active]
509173002136	aspartate-rich region 2; other site
509173002137	Protein of unknown function (DUF419); Region: DUF419; cl15265
509173002138	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
509173002139	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
509173002140	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
509173002141	hypothetical protein; Provisional; Region: PRK10279
509173002142	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
509173002143	nucleophile elbow; other site
509173002144	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
509173002145	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
509173002146	putative acyl-acceptor binding pocket; other site
509173002147	muropeptide transporter; Reviewed; Region: ampG; PRK11902
509173002148	muropeptide transporter; Validated; Region: ampG; cl17669
509173002149	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
509173002150	putative metal dependent hydrolase; Provisional; Region: PRK11598
509173002151	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
509173002152	Sulfatase; Region: Sulfatase; pfam00884
509173002153	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
509173002154	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173002155	active site
509173002156	phosphorylation site [posttranslational modification]
509173002157	intermolecular recognition site; other site
509173002158	dimerization interface [polypeptide binding]; other site
509173002159	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173002160	DNA binding site [nucleotide binding]
509173002161	sensor protein QseC; Provisional; Region: PRK10337
509173002162	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173002163	dimer interface [polypeptide binding]; other site
509173002164	phosphorylation site [posttranslational modification]
509173002165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173002166	ATP binding site [chemical binding]; other site
509173002167	Mg2+ binding site [ion binding]; other site
509173002168	G-X-G motif; other site
509173002169	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
509173002170	active site
509173002171	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
509173002172	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173002173	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173002174	putative DNA binding site [nucleotide binding]; other site
509173002175	putative Zn2+ binding site [ion binding]; other site
509173002176	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
509173002177	dimerization interface [polypeptide binding]; other site
509173002178	Predicted permeases [General function prediction only]; Region: COG0679
509173002179	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
509173002180	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
509173002181	HIGH motif; other site
509173002182	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
509173002183	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
509173002184	active site
509173002185	KMSKS motif; other site
509173002186	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
509173002187	tRNA binding surface [nucleotide binding]; other site
509173002188	anticodon binding site; other site
509173002189	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
509173002190	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173002191	short chain dehydrogenase; Provisional; Region: PRK06181
509173002192	NAD(P) binding site [chemical binding]; other site
509173002193	active site
509173002194	SnoaL-like domain; Region: SnoaL_4; pfam13577
509173002195	Uncharacterized conserved protein [Function unknown]; Region: COG0393
509173002196	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
509173002197	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
509173002198	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
509173002199	Protein export membrane protein; Region: SecD_SecF; cl14618
509173002200	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
509173002201	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173002202	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173002203	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
509173002204	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
509173002205	active site
509173002206	Site-specific recombinase; Region: SpecificRecomb; pfam10136
509173002207	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
509173002208	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
509173002209	substrate binding pocket [chemical binding]; other site
509173002210	chain length determination region; other site
509173002211	substrate-Mg2+ binding site; other site
509173002212	catalytic residues [active]
509173002213	aspartate-rich region 1; other site
509173002214	active site lid residues [active]
509173002215	aspartate-rich region 2; other site
509173002216	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
509173002217	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
509173002218	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
509173002219	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
509173002220	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
509173002221	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
509173002222	seryl-tRNA synthetase; Provisional; Region: PRK05431
509173002223	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
509173002224	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
509173002225	dimer interface [polypeptide binding]; other site
509173002226	active site
509173002227	motif 1; other site
509173002228	motif 2; other site
509173002229	motif 3; other site
509173002230	siroheme synthase; Provisional; Region: cysG; PRK10637
509173002231	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
509173002232	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
509173002233	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
509173002234	active site
509173002235	SAM binding site [chemical binding]; other site
509173002236	homodimer interface [polypeptide binding]; other site
509173002237	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
509173002238	Predicted transcriptional regulators [Transcription]; Region: COG1733
509173002239	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
509173002240	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
509173002241	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
509173002242	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
509173002243	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
509173002244	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189
509173002245	putative active site [active]
509173002246	metal binding site [ion binding]; metal-binding site
509173002247	lipoate-protein ligase B; Provisional; Region: PRK14342
509173002248	Protein of unknown function (DUF493); Region: DUF493; pfam04359
509173002249	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
509173002250	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
509173002251	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
509173002252	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
509173002253	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
509173002254	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
509173002255	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
509173002256	DNA binding residues [nucleotide binding]
509173002257	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
509173002258	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
509173002259	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
509173002260	active site residue [active]
509173002261	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
509173002262	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
509173002263	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
509173002264	dimer interface [polypeptide binding]; other site
509173002265	active site
509173002266	citrylCoA binding site [chemical binding]; other site
509173002267	NADH binding [chemical binding]; other site
509173002268	cationic pore residues; other site
509173002269	oxalacetate/citrate binding site [chemical binding]; other site
509173002270	coenzyme A binding site [chemical binding]; other site
509173002271	catalytic triad [active]
509173002272	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
509173002273	Iron-sulfur protein interface; other site
509173002274	proximal quinone binding site [chemical binding]; other site
509173002275	SdhD (CybS) interface [polypeptide binding]; other site
509173002276	proximal heme binding site [chemical binding]; other site
509173002277	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
509173002278	SdhC subunit interface [polypeptide binding]; other site
509173002279	proximal heme binding site [chemical binding]; other site
509173002280	cardiolipin binding site; other site
509173002281	Iron-sulfur protein interface; other site
509173002282	proximal quinone binding site [chemical binding]; other site
509173002283	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
509173002284	L-aspartate oxidase; Provisional; Region: PRK06175
509173002285	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
509173002286	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
509173002287	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
509173002288	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
509173002289	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
509173002290	TPP-binding site [chemical binding]; other site
509173002291	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
509173002292	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
509173002293	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
509173002294	E3 interaction surface; other site
509173002295	lipoyl attachment site [posttranslational modification]; other site
509173002296	e3 binding domain; Region: E3_binding; pfam02817
509173002297	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
509173002298	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
509173002299	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173002300	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173002301	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
509173002302	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
509173002303	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
509173002304	CoA-ligase; Region: Ligase_CoA; pfam00549
509173002305	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
509173002306	CoA binding domain; Region: CoA_binding; smart00881
509173002307	CoA-ligase; Region: Ligase_CoA; pfam00549
509173002308	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
509173002309	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
509173002310	active site
509173002311	HIGH motif; other site
509173002312	dimer interface [polypeptide binding]; other site
509173002313	KMSKS motif; other site
509173002314	Protein of unknown function (DUF808); Region: DUF808; pfam05661
509173002315	Predicted metalloprotease [General function prediction only]; Region: COG2321
509173002316	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
509173002317	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
509173002318	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
509173002319	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
509173002320	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
509173002321	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
509173002322	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
509173002323	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
509173002324	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
509173002325	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
509173002326	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
509173002327	putative active site [active]
509173002328	putative metal binding site [ion binding]; other site
509173002329	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
509173002330	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
509173002331	active site
509173002332	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
509173002333	DNA binding site [nucleotide binding]
509173002334	active site
509173002335	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
509173002336	Ligand Binding Site [chemical binding]; other site
509173002337	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
509173002338	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
509173002339	trimer interface [polypeptide binding]; other site
509173002340	active site
509173002341	substrate binding site [chemical binding]; other site
509173002342	CoA binding site [chemical binding]; other site
509173002343	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
509173002344	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
509173002345	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
509173002346	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
509173002347	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
509173002348	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
509173002349	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
509173002350	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
509173002351	ATP-grasp domain; Region: ATP-grasp_4; cl17255
509173002352	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
509173002353	IMP binding site; other site
509173002354	dimer interface [polypeptide binding]; other site
509173002355	interdomain contacts; other site
509173002356	partial ornithine binding site; other site
509173002357	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
509173002358	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
509173002359	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
509173002360	catalytic site [active]
509173002361	subunit interface [polypeptide binding]; other site
509173002362	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
509173002363	putative heme binding site [chemical binding]; other site
509173002364	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
509173002365	FtsJ-like methyltransferase; Region: FtsJ; cl17430
509173002366	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
509173002367	FtsH Extracellular; Region: FtsH_ext; pfam06480
509173002368	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
509173002369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173002370	Walker A motif; other site
509173002371	ATP binding site [chemical binding]; other site
509173002372	Walker B motif; other site
509173002373	arginine finger; other site
509173002374	Peptidase family M41; Region: Peptidase_M41; pfam01434
509173002375	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
509173002376	dihydropteroate synthase; Region: DHPS; TIGR01496
509173002377	substrate binding pocket [chemical binding]; other site
509173002378	dimer interface [polypeptide binding]; other site
509173002379	inhibitor binding site; inhibition site
509173002380	PhoD-like phosphatase; Region: PhoD; pfam09423
509173002381	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
509173002382	putative active site [active]
509173002383	putative metal binding site [ion binding]; other site
509173002384	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
509173002385	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
509173002386	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
509173002387	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
509173002388	homodimer interface [polypeptide binding]; other site
509173002389	NADP binding site [chemical binding]; other site
509173002390	substrate binding site [chemical binding]; other site
509173002391	Predicted methyltransferase [General function prediction only]; Region: COG3897
509173002392	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173002393	S-adenosylmethionine binding site [chemical binding]; other site
509173002394	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
509173002395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173002396	putative substrate translocation pore; other site
509173002397	glycerol kinase; Provisional; Region: glpK; PRK00047
509173002398	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
509173002399	N- and C-terminal domain interface [polypeptide binding]; other site
509173002400	active site
509173002401	MgATP binding site [chemical binding]; other site
509173002402	catalytic site [active]
509173002403	metal binding site [ion binding]; metal-binding site
509173002404	glycerol binding site [chemical binding]; other site
509173002405	homotetramer interface [polypeptide binding]; other site
509173002406	homodimer interface [polypeptide binding]; other site
509173002407	FBP binding site [chemical binding]; other site
509173002408	protein IIAGlc interface [polypeptide binding]; other site
509173002409	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
509173002410	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
509173002411	active site
509173002412	substrate-binding site [chemical binding]; other site
509173002413	metal-binding site [ion binding]
509173002414	GTP binding site [chemical binding]; other site
509173002415	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
509173002416	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
509173002417	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
509173002418	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
509173002419	putative active site [active]
509173002420	putative metal binding site [ion binding]; other site
509173002421	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
509173002422	active site
509173002423	metal binding site [ion binding]; metal-binding site
509173002424	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
509173002425	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
509173002426	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
509173002427	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
509173002428	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
509173002429	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
509173002430	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
509173002431	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
509173002432	oligomerisation interface [polypeptide binding]; other site
509173002433	mobile loop; other site
509173002434	roof hairpin; other site
509173002435	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
509173002436	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
509173002437	ring oligomerisation interface [polypeptide binding]; other site
509173002438	ATP/Mg binding site [chemical binding]; other site
509173002439	stacking interactions; other site
509173002440	hinge regions; other site
509173002441	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
509173002442	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
509173002443	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
509173002444	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
509173002445	putative active site [active]
509173002446	catalytic site [active]
509173002447	putative metal binding site [ion binding]; other site
509173002448	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
509173002449	Protein export membrane protein; Region: SecD_SecF; cl14618
509173002450	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
509173002451	heat shock protein HtpX; Provisional; Region: PRK05457
509173002452	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
509173002453	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
509173002454	N-acetyl-D-glucosamine binding site [chemical binding]; other site
509173002455	catalytic residue [active]
509173002456	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
509173002457	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
509173002458	Ligand Binding Site [chemical binding]; other site
509173002459	SCP-2 sterol transfer family; Region: SCP2; pfam02036
509173002460	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
509173002461	N-acetyl-D-glucosamine binding site [chemical binding]; other site
509173002462	catalytic residue [active]
509173002463	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
509173002464	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
509173002465	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
509173002466	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
509173002467	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
509173002468	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
509173002469	acyl-activating enzyme (AAE) consensus motif; other site
509173002470	AMP binding site [chemical binding]; other site
509173002471	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
509173002472	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
509173002473	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
509173002474	putative trimer interface [polypeptide binding]; other site
509173002475	putative CoA binding site [chemical binding]; other site
509173002476	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
509173002477	putative CoA binding site [chemical binding]; other site
509173002478	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
509173002479	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173002480	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173002481	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
509173002482	dimer interface [polypeptide binding]; other site
509173002483	FMN binding site [chemical binding]; other site
509173002484	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
509173002485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173002486	NAD(P) binding site [chemical binding]; other site
509173002487	active site
509173002488	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173002489	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173002490	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
509173002491	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
509173002492	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
509173002493	putative molybdopterin cofactor binding site [chemical binding]; other site
509173002494	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
509173002495	putative molybdopterin cofactor binding site; other site
509173002496	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
509173002497	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
509173002498	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
509173002499	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
509173002500	ligand binding site [chemical binding]; other site
509173002501	NAD binding site [chemical binding]; other site
509173002502	catalytic site [active]
509173002503	homodimer interface [polypeptide binding]; other site
509173002504	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
509173002505	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
509173002506	motif 1; other site
509173002507	dimer interface [polypeptide binding]; other site
509173002508	active site
509173002509	motif 2; other site
509173002510	motif 3; other site
509173002511	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
509173002512	DNA repair protein RadA; Provisional; Region: PRK11823
509173002513	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
509173002514	Walker A motif/ATP binding site; other site
509173002515	ATP binding site [chemical binding]; other site
509173002516	Walker B motif; other site
509173002517	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
509173002518	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
509173002519	diaminopimelate decarboxylase; Region: lysA; TIGR01048
509173002520	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
509173002521	active site
509173002522	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
509173002523	substrate binding site [chemical binding]; other site
509173002524	catalytic residues [active]
509173002525	dimer interface [polypeptide binding]; other site
509173002526	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
509173002527	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
509173002528	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
509173002529	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
509173002530	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
509173002531	catalytic site [active]
509173002532	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173002533	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
509173002534	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
509173002535	active site
509173002536	DNA binding site [nucleotide binding]
509173002537	Int/Topo IB signature motif; other site
509173002538	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
509173002539	Ligand binding site [chemical binding]; other site
509173002540	Electron transfer flavoprotein domain; Region: ETF; pfam01012
509173002541	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
509173002542	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
509173002543	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
509173002544	DNA gyrase subunit A; Validated; Region: PRK05560
509173002545	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
509173002546	CAP-like domain; other site
509173002547	active site
509173002548	primary dimer interface [polypeptide binding]; other site
509173002549	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
509173002550	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
509173002551	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
509173002552	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
509173002553	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
509173002554	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
509173002555	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
509173002556	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
509173002557	GtrA-like protein; Region: GtrA; pfam04138
509173002558	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
509173002559	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
509173002560	Ligand binding site; other site
509173002561	Putative Catalytic site; other site
509173002562	DXD motif; other site
509173002563	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
509173002564	putative active site [active]
509173002565	YdjC motif; other site
509173002566	Mg binding site [ion binding]; other site
509173002567	putative homodimer interface [polypeptide binding]; other site
509173002568	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
509173002569	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
509173002570	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
509173002571	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
509173002572	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
509173002573	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173002574	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173002575	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
509173002576	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
509173002577	homodimer interface [polypeptide binding]; other site
509173002578	substrate-cofactor binding pocket; other site
509173002579	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173002580	catalytic residue [active]
509173002581	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
509173002582	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
509173002583	EamA-like transporter family; Region: EamA; pfam00892
509173002584	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
509173002585	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
509173002586	FtsX-like permease family; Region: FtsX; pfam02687
509173002587	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
509173002588	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
509173002589	Walker A/P-loop; other site
509173002590	ATP binding site [chemical binding]; other site
509173002591	Q-loop/lid; other site
509173002592	ABC transporter signature motif; other site
509173002593	Walker B; other site
509173002594	D-loop; other site
509173002595	H-loop/switch region; other site
509173002596	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
509173002597	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
509173002598	Competence protein; Region: Competence; pfam03772
509173002599	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
509173002600	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
509173002601	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
509173002602	putative acyl-acceptor binding pocket; other site
509173002603	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
509173002604	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
509173002605	tandem repeat interface [polypeptide binding]; other site
509173002606	oligomer interface [polypeptide binding]; other site
509173002607	active site residues [active]
509173002608	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173002609	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
509173002610	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
509173002611	active site
509173002612	substrate binding site [chemical binding]; other site
509173002613	cosubstrate binding site; other site
509173002614	catalytic site [active]
509173002615	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
509173002616	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
509173002617	dimerization interface [polypeptide binding]; other site
509173002618	putative ATP binding site [chemical binding]; other site
509173002619	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
509173002620	Domain of unknown function DUF20; Region: UPF0118; pfam01594
509173002621	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
509173002622	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173002623	Walker A motif; other site
509173002624	ATP binding site [chemical binding]; other site
509173002625	Walker B motif; other site
509173002626	arginine finger; other site
509173002627	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
509173002628	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
509173002629	Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212
509173002630	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
509173002631	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
509173002632	RNA polymerase factor sigma-70; Validated; Region: PRK09047
509173002633	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
509173002634	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
509173002635	DNA binding residues [nucleotide binding]
509173002636	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
509173002637	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
509173002638	fructose-1,6-bisphosphatase family protein; Region: PLN02628
509173002639	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
509173002640	AMP binding site [chemical binding]; other site
509173002641	metal binding site [ion binding]; metal-binding site
509173002642	active site
509173002643	putative outer membrane lipoprotein; Provisional; Region: PRK09967
509173002644	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
509173002645	ligand binding site [chemical binding]; other site
509173002646	translocation protein TolB; Provisional; Region: tolB; PRK04922
509173002647	TolB amino-terminal domain; Region: TolB_N; pfam04052
509173002648	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
509173002649	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
509173002650	TolA protein; Region: tolA_full; TIGR02794
509173002651	TonB C terminal; Region: TonB_2; pfam13103
509173002652	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
509173002653	TolR protein; Region: tolR; TIGR02801
509173002654	TolQ protein; Region: tolQ; TIGR02796
509173002655	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
509173002656	active site
509173002657	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
509173002658	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
509173002659	metal binding site [ion binding]; metal-binding site
509173002660	putative dimer interface [polypeptide binding]; other site
509173002661	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
509173002662	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
509173002663	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173002664	Walker A motif; other site
509173002665	ATP binding site [chemical binding]; other site
509173002666	Walker B motif; other site
509173002667	arginine finger; other site
509173002668	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
509173002669	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
509173002670	RuvA N terminal domain; Region: RuvA_N; pfam01330
509173002671	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
509173002672	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
509173002673	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
509173002674	Zn2+ binding site [ion binding]; other site
509173002675	Mg2+ binding site [ion binding]; other site
509173002676	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
509173002677	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
509173002678	dimerization interface [polypeptide binding]; other site
509173002679	ATP binding site [chemical binding]; other site
509173002680	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
509173002681	dimerization interface [polypeptide binding]; other site
509173002682	ATP binding site [chemical binding]; other site
509173002683	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
509173002684	putative active site [active]
509173002685	catalytic triad [active]
509173002686	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173002687	putative substrate translocation pore; other site
509173002688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
509173002689	enoyl-CoA hydratase; Provisional; Region: PRK06688
509173002690	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173002691	substrate binding site [chemical binding]; other site
509173002692	oxyanion hole (OAH) forming residues; other site
509173002693	trimer interface [polypeptide binding]; other site
509173002694	nicotinamide-nucleotide adenylyltransferase; Provisional; Region: PRK13793
509173002695	active site
509173002696	nucleotide binding site [chemical binding]; other site
509173002697	HIGH motif; other site
509173002698	KMSKS motif; other site
509173002699	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
509173002700	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
509173002701	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
509173002702	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
509173002703	catalytic triad [active]
509173002704	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
509173002705	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
509173002706	Ligand Binding Site [chemical binding]; other site
509173002707	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
509173002708	Ligand Binding Site [chemical binding]; other site
509173002709	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
509173002710	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173002711	FeS/SAM binding site; other site
509173002712	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
509173002713	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
509173002714	active site
509173002715	substrate binding site [chemical binding]; other site
509173002716	trimer interface [polypeptide binding]; other site
509173002717	CoA binding site [chemical binding]; other site
509173002718	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
509173002719	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173002720	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
509173002721	substrate binding site [chemical binding]; other site
509173002722	dimerization interface [polypeptide binding]; other site
509173002723	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
509173002724	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
509173002725	Walker A/P-loop; other site
509173002726	ATP binding site [chemical binding]; other site
509173002727	Q-loop/lid; other site
509173002728	ABC transporter signature motif; other site
509173002729	Walker B; other site
509173002730	D-loop; other site
509173002731	H-loop/switch region; other site
509173002732	TOBE-like domain; Region: TOBE_3; pfam12857
509173002733	sulfate transport protein; Provisional; Region: cysT; CHL00187
509173002734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173002735	dimer interface [polypeptide binding]; other site
509173002736	conserved gate region; other site
509173002737	putative PBP binding loops; other site
509173002738	ABC-ATPase subunit interface; other site
509173002739	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
509173002740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173002741	dimer interface [polypeptide binding]; other site
509173002742	conserved gate region; other site
509173002743	putative PBP binding loops; other site
509173002744	ABC-ATPase subunit interface; other site
509173002745	Serine hydrolase; Region: Ser_hydrolase; pfam06821
509173002746	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
509173002747	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
509173002748	substrate binding pocket [chemical binding]; other site
509173002749	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
509173002750	membrane-bound complex binding site; other site
509173002751	hinge residues; other site
509173002752	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
509173002753	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
509173002754	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173002755	catalytic residue [active]
509173002756	YceG-like family; Region: YceG; pfam02618
509173002757	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
509173002758	dimerization interface [polypeptide binding]; other site
509173002759	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
509173002760	thymidylate kinase; Validated; Region: tmk; PRK00698
509173002761	TMP-binding site; other site
509173002762	ATP-binding site [chemical binding]; other site
509173002763	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
509173002764	CoenzymeA binding site [chemical binding]; other site
509173002765	subunit interaction site [polypeptide binding]; other site
509173002766	PHB binding site; other site
509173002767	L-aspartate oxidase; Provisional; Region: PRK09077
509173002768	L-aspartate oxidase; Provisional; Region: PRK06175
509173002769	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
509173002770	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
509173002771	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
509173002772	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
509173002773	protein binding site [polypeptide binding]; other site
509173002774	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
509173002775	protein binding site [polypeptide binding]; other site
509173002776	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
509173002777	active site
509173002778	GTP-binding protein LepA; Provisional; Region: PRK05433
509173002779	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
509173002780	G1 box; other site
509173002781	putative GEF interaction site [polypeptide binding]; other site
509173002782	GTP/Mg2+ binding site [chemical binding]; other site
509173002783	Switch I region; other site
509173002784	G2 box; other site
509173002785	G3 box; other site
509173002786	Switch II region; other site
509173002787	G4 box; other site
509173002788	G5 box; other site
509173002789	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
509173002790	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
509173002791	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
509173002792	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
509173002793	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
509173002794	Catalytic site [active]
509173002795	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
509173002796	ribonuclease III; Reviewed; Region: rnc; PRK00102
509173002797	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
509173002798	dimerization interface [polypeptide binding]; other site
509173002799	active site
509173002800	metal binding site [ion binding]; metal-binding site
509173002801	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
509173002802	dsRNA binding site [nucleotide binding]; other site
509173002803	GTPase Era; Reviewed; Region: era; PRK00089
509173002804	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
509173002805	G1 box; other site
509173002806	GTP/Mg2+ binding site [chemical binding]; other site
509173002807	Switch I region; other site
509173002808	G2 box; other site
509173002809	Switch II region; other site
509173002810	G3 box; other site
509173002811	G4 box; other site
509173002812	G5 box; other site
509173002813	KH domain; Region: KH_2; pfam07650
509173002814	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
509173002815	Recombination protein O N terminal; Region: RecO_N; pfam11967
509173002816	Recombination protein O C terminal; Region: RecO_C; pfam02565
509173002817	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
509173002818	active site
509173002819	hydrophilic channel; other site
509173002820	dimerization interface [polypeptide binding]; other site
509173002821	catalytic residues [active]
509173002822	active site lid [active]
509173002823	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
509173002824	active site
509173002825	dinuclear metal binding site [ion binding]; other site
509173002826	dimerization interface [polypeptide binding]; other site
509173002827	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173002828	malonic semialdehyde reductase; Provisional; Region: PRK10538
509173002829	NAD(P) binding site [chemical binding]; other site
509173002830	active site
509173002831	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
509173002832	CoenzymeA binding site [chemical binding]; other site
509173002833	subunit interaction site [polypeptide binding]; other site
509173002834	PHB binding site; other site
509173002835	Uncharacterized conserved protein [Function unknown]; Region: COG3791
509173002836	aspartate aminotransferase; Provisional; Region: PRK05764
509173002837	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173002838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173002839	homodimer interface [polypeptide binding]; other site
509173002840	catalytic residue [active]
509173002841	PAS domain; Region: PAS_9; pfam13426
509173002842	PAS domain; Region: PAS_9; pfam13426
509173002843	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
509173002844	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
509173002845	metal binding site [ion binding]; metal-binding site
509173002846	active site
509173002847	I-site; other site
509173002848	hypothetical protein; Region: PHA00684
509173002849	excinuclease ABC subunit B; Provisional; Region: PRK05298
509173002850	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
509173002851	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
509173002852	ATP-binding site [chemical binding]; other site
509173002853	ATP binding site [chemical binding]; other site
509173002854	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
509173002855	nucleotide binding region [chemical binding]; other site
509173002856	ATP-binding site [chemical binding]; other site
509173002857	Ultra-violet resistance protein B; Region: UvrB; pfam12344
509173002858	UvrB/uvrC motif; Region: UVR; pfam02151
509173002859	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
509173002860	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
509173002861	Predicted permeases [General function prediction only]; Region: RarD; COG2962
509173002862	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
509173002863	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
509173002864	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
509173002865	GTPase CgtA; Reviewed; Region: obgE; PRK12298
509173002866	GTP1/OBG; Region: GTP1_OBG; pfam01018
509173002867	Obg GTPase; Region: Obg; cd01898
509173002868	G1 box; other site
509173002869	GTP/Mg2+ binding site [chemical binding]; other site
509173002870	Switch I region; other site
509173002871	G2 box; other site
509173002872	G3 box; other site
509173002873	Switch II region; other site
509173002874	G4 box; other site
509173002875	G5 box; other site
509173002876	gamma-glutamyl kinase; Provisional; Region: PRK05429
509173002877	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
509173002878	nucleotide binding site [chemical binding]; other site
509173002879	homotetrameric interface [polypeptide binding]; other site
509173002880	putative phosphate binding site [ion binding]; other site
509173002881	putative allosteric binding site; other site
509173002882	PUA domain; Region: PUA; pfam01472
509173002883	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
509173002884	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
509173002885	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
509173002886	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
509173002887	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
509173002888	FMN binding site [chemical binding]; other site
509173002889	active site
509173002890	catalytic residues [active]
509173002891	substrate binding site [chemical binding]; other site
509173002892	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
509173002893	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
509173002894	FMN binding site [chemical binding]; other site
509173002895	substrate binding site [chemical binding]; other site
509173002896	putative catalytic residue [active]
509173002897	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
509173002898	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
509173002899	TPR motif; other site
509173002900	binding surface
509173002901	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
509173002902	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
509173002903	active site
509173002904	homodimer interface [polypeptide binding]; other site
509173002905	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
509173002906	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
509173002907	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
509173002908	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
509173002909	DXD motif; other site
509173002910	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
509173002911	DNA photolyase; Region: DNA_photolyase; pfam00875
509173002912	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
509173002913	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
509173002914	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
509173002915	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173002916	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
509173002917	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
509173002918	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
509173002919	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
509173002920	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
509173002921	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
509173002922	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
509173002923	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
509173002924	pseudouridine synthase; Region: TIGR00093
509173002925	probable active site [active]
509173002926	isocitrate dehydrogenase; Validated; Region: PRK06451
509173002927	isocitrate dehydrogenase; Reviewed; Region: PRK07006
509173002928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173002929	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173002930	putative substrate translocation pore; other site
509173002931	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173002932	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173002933	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
509173002934	putative dimerization interface [polypeptide binding]; other site
509173002935	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
509173002936	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
509173002937	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
509173002938	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
509173002939	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
509173002940	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
509173002941	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
509173002942	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
509173002943	Protein of unknown function (DUF3144); Region: DUF3144; pfam11342
509173002944	Uncharacterized conserved protein [Function unknown]; Region: COG3025
509173002945	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
509173002946	putative active site [active]
509173002947	putative metal binding residues [ion binding]; other site
509173002948	signature motif; other site
509173002949	putative triphosphate binding site [ion binding]; other site
509173002950	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
509173002951	Protein of unknown function (DUF962); Region: DUF962; pfam06127
509173002952	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
509173002953	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
509173002954	CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562
509173002955	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
509173002956	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736
509173002957	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
509173002958	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
509173002959	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
509173002960	thiamine phosphate binding site [chemical binding]; other site
509173002961	active site
509173002962	pyrophosphate binding site [ion binding]; other site
509173002963	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
509173002964	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
509173002965	inhibitor-cofactor binding pocket; inhibition site
509173002966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173002967	catalytic residue [active]
509173002968	Phosphopantetheine attachment site; Region: PP-binding; cl09936
509173002969	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
509173002970	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
509173002971	active site
509173002972	ATP-dependent helicase HepA; Validated; Region: PRK04914
509173002973	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
509173002974	ATP binding site [chemical binding]; other site
509173002975	putative Mg++ binding site [ion binding]; other site
509173002976	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
509173002977	nucleotide binding region [chemical binding]; other site
509173002978	ATP-binding site [chemical binding]; other site
509173002979	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
509173002980	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
509173002981	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173002982	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
509173002983	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
509173002984	FAD binding pocket [chemical binding]; other site
509173002985	FAD binding motif [chemical binding]; other site
509173002986	phosphate binding motif [ion binding]; other site
509173002987	beta-alpha-beta structure motif; other site
509173002988	NAD binding pocket [chemical binding]; other site
509173002989	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
509173002990	catalytic loop [active]
509173002991	iron binding site [ion binding]; other site
509173002992	Fatty acid desaturase; Region: FA_desaturase; pfam00487
509173002993	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
509173002994	putative di-iron ligands [ion binding]; other site
509173002995	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173002996	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173002997	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
509173002998	CoenzymeA binding site [chemical binding]; other site
509173002999	subunit interaction site [polypeptide binding]; other site
509173003000	PHB binding site; other site
509173003001	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173003002	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173003003	Protein of unknown function (DUF541); Region: SIMPL; cl01077
509173003004	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
509173003005	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
509173003006	inhibitor-cofactor binding pocket; inhibition site
509173003007	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173003008	catalytic residue [active]
509173003009	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
509173003010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173003011	catalytic residue [active]
509173003012	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
509173003013	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
509173003014	NAD(P) binding site [chemical binding]; other site
509173003015	catalytic residues [active]
509173003016	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
509173003017	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
509173003018	AsnC family; Region: AsnC_trans_reg; pfam01037
509173003019	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
509173003020	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
509173003021	dimer interface [polypeptide binding]; other site
509173003022	PYR/PP interface [polypeptide binding]; other site
509173003023	TPP binding site [chemical binding]; other site
509173003024	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
509173003025	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
509173003026	TPP-binding site [chemical binding]; other site
509173003027	dimer interface [polypeptide binding]; other site
509173003028	aromatic amino acid transporter; Provisional; Region: PRK10238
509173003029	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
509173003030	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
509173003031	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
509173003032	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173003033	dimer interface [polypeptide binding]; other site
509173003034	conserved gate region; other site
509173003035	putative PBP binding loops; other site
509173003036	ABC-ATPase subunit interface; other site
509173003037	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
509173003038	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
509173003039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173003040	dimer interface [polypeptide binding]; other site
509173003041	conserved gate region; other site
509173003042	putative PBP binding loops; other site
509173003043	ABC-ATPase subunit interface; other site
509173003044	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
509173003045	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
509173003046	Walker A/P-loop; other site
509173003047	ATP binding site [chemical binding]; other site
509173003048	Q-loop/lid; other site
509173003049	ABC transporter signature motif; other site
509173003050	Walker B; other site
509173003051	D-loop; other site
509173003052	H-loop/switch region; other site
509173003053	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
509173003054	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
509173003055	tandem repeat interface [polypeptide binding]; other site
509173003056	oligomer interface [polypeptide binding]; other site
509173003057	active site residues [active]
509173003058	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
509173003059	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
509173003060	adenylosuccinate lyase; Provisional; Region: PRK09285
509173003061	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
509173003062	tetramer interface [polypeptide binding]; other site
509173003063	active site
509173003064	putative lysogenization regulator; Reviewed; Region: PRK00218
509173003065	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
509173003066	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
509173003067	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
509173003068	nudix motif; other site
509173003069	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
509173003070	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
509173003071	trimer interface [polypeptide binding]; other site
509173003072	putative metal binding site [ion binding]; other site
509173003073	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
509173003074	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
509173003075	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
509173003076	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
509173003077	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
509173003078	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173003079	Peptidase family M23; Region: Peptidase_M23; pfam01551
509173003080	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173003081	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173003082	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
509173003083	putative effector binding pocket; other site
509173003084	dimerization interface [polypeptide binding]; other site
509173003085	AAA domain; Region: AAA_32; pfam13654
509173003086	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
509173003087	primary dimer interface [polypeptide binding]; other site
509173003088	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
509173003089	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
509173003090	muropeptide transporter; Validated; Region: ampG; cl17669
509173003091	muropeptide transporter; Validated; Region: ampG; cl17669
509173003092	muropeptide transporter; Validated; Region: ampG; cl17669
509173003093	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
509173003094	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
509173003095	dimer interface [polypeptide binding]; other site
509173003096	active site
509173003097	metal binding site [ion binding]; metal-binding site
509173003098	glutathione binding site [chemical binding]; other site
509173003099	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
509173003100	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
509173003101	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
509173003102	PAS domain S-box; Region: sensory_box; TIGR00229
509173003103	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
509173003104	Radical SAM superfamily; Region: Radical_SAM; pfam04055
509173003105	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173003106	FeS/SAM binding site; other site
509173003107	elongation factor P; Validated; Region: PRK00529
509173003108	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
509173003109	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
509173003110	RNA binding site [nucleotide binding]; other site
509173003111	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
509173003112	RNA binding site [nucleotide binding]; other site
509173003113	carbon starvation protein A; Provisional; Region: PRK15015
509173003114	Carbon starvation protein CstA; Region: CstA; pfam02554
509173003115	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
509173003116	Protein of unknown function (DUF466); Region: DUF466; pfam04328
509173003117	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
509173003118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173003119	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
509173003120	dimerization interface [polypeptide binding]; other site
509173003121	substrate binding pocket [chemical binding]; other site
509173003122	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
509173003123	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
509173003124	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
509173003125	active site
509173003126	BCCT family transporter; Region: BCCT; pfam02028
509173003127	BCCT family transporter; Region: BCCT; pfam02028
509173003128	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
509173003129	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
509173003130	[2Fe-2S] cluster binding site [ion binding]; other site
509173003131	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
509173003132	alpha subunit interface [polypeptide binding]; other site
509173003133	active site
509173003134	substrate binding site [chemical binding]; other site
509173003135	Fe binding site [ion binding]; other site
509173003136	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
509173003137	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
509173003138	NAD(P) binding site [chemical binding]; other site
509173003139	catalytic residues [active]
509173003140	Rubredoxin [Energy production and conversion]; Region: COG1773
509173003141	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
509173003142	iron binding site [ion binding]; other site
509173003143	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
509173003144	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173003145	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
509173003146	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
509173003147	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
509173003148	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
509173003149	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
509173003150	aromatic amino acid exporter; Provisional; Region: PRK11689
509173003151	EamA-like transporter family; Region: EamA; pfam00892
509173003152	EamA-like transporter family; Region: EamA; pfam00892
509173003153	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
509173003154	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173003155	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173003156	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173003157	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173003158	Pirin-related protein [General function prediction only]; Region: COG1741
509173003159	Pirin; Region: Pirin; pfam02678
509173003160	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
509173003161	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
509173003162	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
509173003163	tetramer interface [polypeptide binding]; other site
509173003164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173003165	catalytic residue [active]
509173003166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
509173003167	YheO-like PAS domain; Region: PAS_6; pfam08348
509173003168	HTH domain; Region: HTH_22; pfam13309
509173003169	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
509173003170	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
509173003171	FAD binding pocket [chemical binding]; other site
509173003172	FAD binding motif [chemical binding]; other site
509173003173	phosphate binding motif [ion binding]; other site
509173003174	NAD binding pocket [chemical binding]; other site
509173003175	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
509173003176	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
509173003177	acyl-activating enzyme (AAE) consensus motif; other site
509173003178	AMP binding site [chemical binding]; other site
509173003179	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
509173003180	Condensation domain; Region: Condensation; pfam00668
509173003181	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
509173003182	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
509173003183	ABC-ATPase subunit  interface; other site
509173003184	dimer interface [polypeptide binding]; other site
509173003185	putative PBP binding regions; other site
509173003186	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
509173003187	ABC-ATPase subunit  interface; other site
509173003188	dimer interface [polypeptide binding]; other site
509173003189	putative PBP binding regions; other site
509173003190	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
509173003191	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
509173003192	Walker A/P-loop; other site
509173003193	ATP binding site [chemical binding]; other site
509173003194	Q-loop/lid; other site
509173003195	ABC transporter signature motif; other site
509173003196	Walker B; other site
509173003197	D-loop; other site
509173003198	H-loop/switch region; other site
509173003199	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
509173003200	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
509173003201	putative ligand binding residues [chemical binding]; other site
509173003202	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
509173003203	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173003204	N-terminal plug; other site
509173003205	ligand-binding site [chemical binding]; other site
509173003206	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
509173003207	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173003208	Condensation domain; Region: Condensation; pfam00668
509173003209	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
509173003210	Nonribosomal peptide synthase; Region: NRPS; pfam08415
509173003211	Condensation domain; Region: Condensation; pfam00668
509173003212	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
509173003213	Nonribosomal peptide synthase; Region: NRPS; pfam08415
509173003214	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
509173003215	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
509173003216	acyl-activating enzyme (AAE) consensus motif; other site
509173003217	active site
509173003218	AMP binding site [chemical binding]; other site
509173003219	substrate binding site [chemical binding]; other site
509173003220	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
509173003221	hydrophobic substrate binding pocket; other site
509173003222	Isochorismatase family; Region: Isochorismatase; pfam00857
509173003223	active site
509173003224	conserved cis-peptide bond; other site
509173003225	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
509173003226	histidine decarboxylase; Provisional; Region: PRK02769
509173003227	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
509173003228	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
509173003229	catalytic residue [active]
509173003230	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
509173003231	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173003232	Walker A/P-loop; other site
509173003233	ATP binding site [chemical binding]; other site
509173003234	Q-loop/lid; other site
509173003235	ABC transporter signature motif; other site
509173003236	Walker B; other site
509173003237	D-loop; other site
509173003238	H-loop/switch region; other site
509173003239	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173003240	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
509173003241	Walker A/P-loop; other site
509173003242	ATP binding site [chemical binding]; other site
509173003243	Q-loop/lid; other site
509173003244	ABC transporter signature motif; other site
509173003245	Walker B; other site
509173003246	D-loop; other site
509173003247	H-loop/switch region; other site
509173003248	Thioesterase domain; Region: Thioesterase; pfam00975
509173003249	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
509173003250	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
509173003251	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
509173003252	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
509173003253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
509173003254	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
509173003255	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
509173003256	substrate binding site [chemical binding]; other site
509173003257	active site
509173003258	Protein of unknown function (DUF817); Region: DUF817; pfam05675
509173003259	Protein of unknown function (DUF3015); Region: DUF3015; pfam11220
509173003260	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
509173003261	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
509173003262	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
509173003263	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173003264	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173003265	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
509173003266	homodecamer interface [polypeptide binding]; other site
509173003267	GTP cyclohydrolase I; Provisional; Region: PLN03044
509173003268	active site
509173003269	putative catalytic site residues [active]
509173003270	zinc binding site [ion binding]; other site
509173003271	GTP-CH-I/GFRP interaction surface; other site
509173003272	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
509173003273	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
509173003274	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
509173003275	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
509173003276	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
509173003277	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
509173003278	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
509173003279	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
509173003280	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
509173003281	XdhC Rossmann domain; Region: XdhC_C; pfam13478
509173003282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
509173003283	Smr domain; Region: Smr; pfam01713
509173003284	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
509173003285	active site
509173003286	ribulose/triose binding site [chemical binding]; other site
509173003287	phosphate binding site [ion binding]; other site
509173003288	substrate (anthranilate) binding pocket [chemical binding]; other site
509173003289	product (indole) binding pocket [chemical binding]; other site
509173003290	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
509173003291	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
509173003292	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
509173003293	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
509173003294	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
509173003295	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
509173003296	Peptidase family M1; Region: Peptidase_M1; pfam01433
509173003297	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
509173003298	Zn binding site [ion binding]; other site
509173003299	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
509173003300	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
509173003301	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
509173003302	glutamine binding [chemical binding]; other site
509173003303	catalytic triad [active]
509173003304	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
509173003305	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
509173003306	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
509173003307	active site
509173003308	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
509173003309	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173003310	putative substrate translocation pore; other site
509173003311	POT family; Region: PTR2; cl17359
509173003312	glutamine synthetase; Provisional; Region: glnA; PRK09469
509173003313	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
509173003314	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
509173003315	Chorismate lyase; Region: Chor_lyase; cl01230
509173003316	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
509173003317	UbiA prenyltransferase family; Region: UbiA; pfam01040
509173003318	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
509173003319	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
509173003320	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173003321	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173003322	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
509173003323	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
509173003324	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
509173003325	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
509173003326	Uncharacterized conserved protein [Function unknown]; Region: COG0327
509173003327	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
509173003328	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
509173003329	protein binding site [polypeptide binding]; other site
509173003330	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
509173003331	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
509173003332	active site
509173003333	NTP binding site [chemical binding]; other site
509173003334	metal binding triad [ion binding]; metal-binding site
509173003335	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
509173003336	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
509173003337	Zn2+ binding site [ion binding]; other site
509173003338	Mg2+ binding site [ion binding]; other site
509173003339	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
509173003340	Malic enzyme, N-terminal domain; Region: malic; pfam00390
509173003341	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
509173003342	putative NAD(P) binding site [chemical binding]; other site
509173003343	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
509173003344	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
509173003345	PAS fold; Region: PAS_3; pfam08447
509173003346	heme pocket [chemical binding]; other site
509173003347	putative active site [active]
509173003348	PAS domain S-box; Region: sensory_box; TIGR00229
509173003349	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
509173003350	putative active site [active]
509173003351	heme pocket [chemical binding]; other site
509173003352	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
509173003353	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
509173003354	metal binding site [ion binding]; metal-binding site
509173003355	active site
509173003356	I-site; other site
509173003357	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
509173003358	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
509173003359	RNA methyltransferase, RsmE family; Region: TIGR00046
509173003360	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
509173003361	FAD binding site [chemical binding]; other site
509173003362	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
509173003363	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
509173003364	homotetramer interface [polypeptide binding]; other site
509173003365	ligand binding site [chemical binding]; other site
509173003366	catalytic site [active]
509173003367	NAD binding site [chemical binding]; other site
509173003368	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
509173003369	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
509173003370	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
509173003371	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173003372	active site
509173003373	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
509173003374	lipoyl synthase; Provisional; Region: PRK05481
509173003375	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173003376	FeS/SAM binding site; other site
509173003377	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
509173003378	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
509173003379	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173003380	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
509173003381	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173003382	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173003383	putative substrate translocation pore; other site
509173003384	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
509173003385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173003386	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
509173003387	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
509173003388	active site
509173003389	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
509173003390	rRNA interaction site [nucleotide binding]; other site
509173003391	S8 interaction site; other site
509173003392	putative laminin-1 binding site; other site
509173003393	elongation factor Ts; Provisional; Region: tsf; PRK09377
509173003394	UBA/TS-N domain; Region: UBA; pfam00627
509173003395	Elongation factor TS; Region: EF_TS; pfam00889
509173003396	Elongation factor TS; Region: EF_TS; pfam00889
509173003397	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
509173003398	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
509173003399	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
509173003400	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173003401	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173003402	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
509173003403	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
509173003404	Protein of unknown function (DUF962); Region: DUF962; cl01879
509173003405	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
509173003406	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
509173003407	Transglycosylase SLT domain; Region: SLT_2; pfam13406
509173003408	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
509173003409	N-acetyl-D-glucosamine binding site [chemical binding]; other site
509173003410	catalytic residue [active]
509173003411	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
509173003412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
509173003413	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
509173003414	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
509173003415	inner membrane transport permease; Provisional; Region: PRK15066
509173003416	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
509173003417	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
509173003418	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
509173003419	Walker A/P-loop; other site
509173003420	ATP binding site [chemical binding]; other site
509173003421	Q-loop/lid; other site
509173003422	ABC transporter signature motif; other site
509173003423	Walker B; other site
509173003424	D-loop; other site
509173003425	H-loop/switch region; other site
509173003426	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
509173003427	exodeoxyribonuclease X; Provisional; Region: PRK07983
509173003428	active site
509173003429	catalytic site [active]
509173003430	substrate binding site [chemical binding]; other site
509173003431	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
509173003432	Secretory lipase; Region: LIP; pfam03583
509173003433	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
509173003434	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
509173003435	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
509173003436	dimer interface [polypeptide binding]; other site
509173003437	active site
509173003438	glycine-pyridoxal phosphate binding site [chemical binding]; other site
509173003439	folate binding site [chemical binding]; other site
509173003440	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
509173003441	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
509173003442	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
509173003443	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173003444	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173003445	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173003446	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173003447	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
509173003448	putative effector binding pocket; other site
509173003449	putative dimerization interface [polypeptide binding]; other site
509173003450	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
509173003451	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
509173003452	substrate binding pocket [chemical binding]; other site
509173003453	membrane-bound complex binding site; other site
509173003454	hinge residues; other site
509173003455	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
509173003456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173003457	dimer interface [polypeptide binding]; other site
509173003458	conserved gate region; other site
509173003459	putative PBP binding loops; other site
509173003460	ABC-ATPase subunit interface; other site
509173003461	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
509173003462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173003463	dimer interface [polypeptide binding]; other site
509173003464	conserved gate region; other site
509173003465	putative PBP binding loops; other site
509173003466	ABC-ATPase subunit interface; other site
509173003467	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
509173003468	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
509173003469	Walker A/P-loop; other site
509173003470	ATP binding site [chemical binding]; other site
509173003471	Q-loop/lid; other site
509173003472	ABC transporter signature motif; other site
509173003473	Walker B; other site
509173003474	D-loop; other site
509173003475	H-loop/switch region; other site
509173003476	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
509173003477	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
509173003478	putative protease; Provisional; Region: PRK15452
509173003479	Peptidase family U32; Region: Peptidase_U32; pfam01136
509173003480	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
509173003481	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173003482	DNA-binding site [nucleotide binding]; DNA binding site
509173003483	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173003484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173003485	homodimer interface [polypeptide binding]; other site
509173003486	catalytic residue [active]
509173003487	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
509173003488	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
509173003489	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
509173003490	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
509173003491	FAD binding pocket [chemical binding]; other site
509173003492	FAD binding motif [chemical binding]; other site
509173003493	phosphate binding motif [ion binding]; other site
509173003494	beta-alpha-beta structure motif; other site
509173003495	NAD binding pocket [chemical binding]; other site
509173003496	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1)
509173003497	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173003498	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2)
509173003499	Predicted membrane protein [Function unknown]; Region: COG3174
509173003500	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
509173003501	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
509173003502	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
509173003503	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
509173003504	Walker A motif; other site
509173003505	ATP binding site [chemical binding]; other site
509173003506	Walker B motif; other site
509173003507	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
509173003508	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
509173003509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173003510	active site
509173003511	phosphorylation site [posttranslational modification]
509173003512	intermolecular recognition site; other site
509173003513	dimerization interface [polypeptide binding]; other site
509173003514	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173003515	DNA binding site [nucleotide binding]
509173003516	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
509173003517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173003518	dimer interface [polypeptide binding]; other site
509173003519	phosphorylation site [posttranslational modification]
509173003520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173003521	ATP binding site [chemical binding]; other site
509173003522	Mg2+ binding site [ion binding]; other site
509173003523	G-X-G motif; other site
509173003524	hypothetical protein; Provisional; Region: PRK08999
509173003525	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
509173003526	active site
509173003527	8-oxo-dGMP binding site [chemical binding]; other site
509173003528	nudix motif; other site
509173003529	metal binding site [ion binding]; metal-binding site
509173003530	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
509173003531	thiamine phosphate binding site [chemical binding]; other site
509173003532	active site
509173003533	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
509173003534	Transglycosylase; Region: Transgly; pfam00912
509173003535	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
509173003536	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231
509173003537	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
509173003538	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
509173003539	hypothetical protein; Validated; Region: PRK09071
509173003540	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
509173003541	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
509173003542	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
509173003543	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
509173003544	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173003545	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173003546	active site
509173003547	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
509173003548	Chorismate mutase type II; Region: CM_2; cl00693
509173003549	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
509173003550	Prephenate dehydratase; Region: PDT; pfam00800
509173003551	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
509173003552	putative L-Phe binding site [chemical binding]; other site
509173003553	bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806
509173003554	prephenate dehydrogenase; Validated; Region: PRK08507
509173003555	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
509173003556	hinge; other site
509173003557	active site
509173003558	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
509173003559	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
509173003560	metal binding site [ion binding]; metal-binding site
509173003561	dimer interface [polypeptide binding]; other site
509173003562	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
509173003563	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
509173003564	hypothetical protein; Validated; Region: PRK02101
509173003565	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
509173003566	ThiS interaction site; other site
509173003567	putative active site [active]
509173003568	tetramer interface [polypeptide binding]; other site
509173003569	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
509173003570	thiS-thiF/thiG interaction site; other site
509173003571	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
509173003572	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
509173003573	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
509173003574	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
509173003575	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
509173003576	DNA binding residues [nucleotide binding]
509173003577	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
509173003578	CPxP  motif; other site
509173003579	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
509173003580	DNA-binding site [nucleotide binding]; DNA binding site
509173003581	RNA-binding motif; other site
509173003582	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
509173003583	DEAD-like helicases superfamily; Region: DEXDc; smart00487
509173003584	ATP binding site [chemical binding]; other site
509173003585	Mg++ binding site [ion binding]; other site
509173003586	motif III; other site
509173003587	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
509173003588	nucleotide binding region [chemical binding]; other site
509173003589	ATP-binding site [chemical binding]; other site
509173003590	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
509173003591	putative FMN binding site [chemical binding]; other site
509173003592	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
509173003593	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
509173003594	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
509173003595	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
509173003596	catalytic core [active]
509173003597	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
509173003598	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
509173003599	active site
509173003600	DNA binding site [nucleotide binding]
509173003601	Int/Topo IB signature motif; other site
509173003602	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
509173003603	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
509173003604	non-specific DNA binding site [nucleotide binding]; other site
509173003605	sequence-specific DNA binding site [nucleotide binding]; other site
509173003606	salt bridge; other site
509173003607	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
509173003608	Catalytic site [active]
509173003609	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
509173003610	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
509173003611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173003612	Walker A motif; other site
509173003613	ATP binding site [chemical binding]; other site
509173003614	Walker B motif; other site
509173003615	arginine finger; other site
509173003616	Endodeoxyribonuclease RusA; Region: RusA; cl01885
509173003617	hypothetical protein; Region: PHA00670
509173003618	Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236
509173003619	hypothetical protein; Region: PHA00662
509173003620	hypothetical protein; Region: PHA00661
509173003621	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
509173003622	aromatic chitin/cellulose binding site residues [chemical binding]; other site
509173003623	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
509173003624	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173003625	Coenzyme A binding pocket [chemical binding]; other site
509173003626	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
509173003627	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
509173003628	N-acetyl-D-glucosamine binding site [chemical binding]; other site
509173003629	catalytic residue [active]
509173003630	structural protein; Region: PHA01972
509173003631	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
509173003632	active site
509173003633	oxyanion hole [active]
509173003634	catalytic triad [active]
509173003635	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
509173003636	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
509173003637	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
509173003638	GspL periplasmic domain; Region: GspL_C; cl14909
509173003639	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
509173003640	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
509173003641	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
509173003642	quinone interaction residues [chemical binding]; other site
509173003643	active site
509173003644	catalytic residues [active]
509173003645	FMN binding site [chemical binding]; other site
509173003646	substrate binding site [chemical binding]; other site
509173003647	Colicin V production protein; Region: Colicin_V; pfam02674
509173003648	amidophosphoribosyltransferase; Provisional; Region: PRK09246
509173003649	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
509173003650	active site
509173003651	tetramer interface [polypeptide binding]; other site
509173003652	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
509173003653	active site
509173003654	Peptidase family M48; Region: Peptidase_M48; cl12018
509173003655	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
509173003656	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
509173003657	dimerization interface [polypeptide binding]; other site
509173003658	ligand binding site [chemical binding]; other site
509173003659	NADP binding site [chemical binding]; other site
509173003660	catalytic site [active]
509173003661	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
509173003662	Peptidase family M48; Region: Peptidase_M48; cl12018
509173003663	Yqey-like protein; Region: YqeY; pfam09424
509173003664	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
509173003665	UGMP family protein; Validated; Region: PRK09604
509173003666	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
509173003667	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
509173003668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173003669	Walker A motif; other site
509173003670	ATP binding site [chemical binding]; other site
509173003671	Walker B motif; other site
509173003672	Domain of unknown function (DUF3336); Region: DUF3336; pfam11815
509173003673	Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206
509173003674	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
509173003675	active site
509173003676	nucleophile elbow; other site
509173003677	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
509173003678	substrate binding site [chemical binding]; other site
509173003679	activation loop (A-loop); other site
509173003680	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
509173003681	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173003682	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173003683	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
509173003684	dimerization interface [polypeptide binding]; other site
509173003685	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
509173003686	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
509173003687	inhibitor-cofactor binding pocket; inhibition site
509173003688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173003689	catalytic residue [active]
509173003690	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
509173003691	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
509173003692	tetrameric interface [polypeptide binding]; other site
509173003693	NAD binding site [chemical binding]; other site
509173003694	catalytic residues [active]
509173003695	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
509173003696	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939
509173003697	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173003698	active site
509173003699	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
509173003700	Methyltransferase domain; Region: Methyltransf_31; pfam13847
509173003701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173003702	S-adenosylmethionine binding site [chemical binding]; other site
509173003703	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
509173003704	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
509173003705	active site
509173003706	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
509173003707	Sensors of blue-light using FAD; Region: BLUF; pfam04940
509173003708	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173003709	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
509173003710	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173003711	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173003712	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173003713	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
509173003714	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
509173003715	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
509173003716	Putative cyclase; Region: Cyclase; pfam04199
509173003717	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
509173003718	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173003719	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
509173003720	dimerization interface [polypeptide binding]; other site
509173003721	substrate binding pocket [chemical binding]; other site
509173003722	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
509173003723	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
509173003724	active site
509173003725	catalytic tetrad [active]
509173003726	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
509173003727	classical (c) SDRs; Region: SDR_c; cd05233
509173003728	NAD(P) binding site [chemical binding]; other site
509173003729	active site
509173003730	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
509173003731	putative hydrophobic ligand binding site [chemical binding]; other site
509173003732	protein interface [polypeptide binding]; other site
509173003733	gate; other site
509173003734	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
509173003735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173003736	Walker A motif; other site
509173003737	ATP binding site [chemical binding]; other site
509173003738	Walker B motif; other site
509173003739	Transcriptional regulators [Transcription]; Region: FadR; COG2186
509173003740	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173003741	DNA-binding site [nucleotide binding]; DNA binding site
509173003742	FCD domain; Region: FCD; pfam07729
509173003743	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173003744	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173003745	Spore Coat Protein U domain; Region: SCPU; pfam05229
509173003746	Spore Coat Protein U domain; Region: SCPU; cl02253
509173003747	Spore Coat Protein U domain; Region: SCPU; pfam05229
509173003748	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
509173003749	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
509173003750	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
509173003751	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
509173003752	PapC C-terminal domain; Region: PapC_C; pfam13953
509173003753	Spore Coat Protein U domain; Region: SCPU; cl02253
509173003754	Spore Coat Protein U domain; Region: SCPU; pfam05229
509173003755	proline/glycine betaine transporter; Provisional; Region: PRK10642
509173003756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173003757	putative substrate translocation pore; other site
509173003758	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
509173003759	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173003760	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173003761	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
509173003762	EamA-like transporter family; Region: EamA; pfam00892
509173003763	EamA-like transporter family; Region: EamA; pfam00892
509173003764	Paraquat-inducible protein A; Region: PqiA; pfam04403
509173003765	Paraquat-inducible protein A; Region: PqiA; pfam04403
509173003766	mce related protein; Region: MCE; pfam02470
509173003767	mce related protein; Region: MCE; pfam02470
509173003768	mce related protein; Region: MCE; pfam02470
509173003769	Protein of unknown function (DUF330); Region: DUF330; pfam03886
509173003770	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
509173003771	active site
509173003772	homotetramer interface [polypeptide binding]; other site
509173003773	Domain of unknown function (DUF336); Region: DUF336; pfam03928
509173003774	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
509173003775	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173003776	active site
509173003777	phosphorylation site [posttranslational modification]
509173003778	intermolecular recognition site; other site
509173003779	dimerization interface [polypeptide binding]; other site
509173003780	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173003781	DNA binding site [nucleotide binding]
509173003782	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
509173003783	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
509173003784	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173003785	dimer interface [polypeptide binding]; other site
509173003786	phosphorylation site [posttranslational modification]
509173003787	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173003788	ATP binding site [chemical binding]; other site
509173003789	Mg2+ binding site [ion binding]; other site
509173003790	G-X-G motif; other site
509173003791	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
509173003792	Fatty acid desaturase; Region: FA_desaturase; pfam00487
509173003793	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
509173003794	Di-iron ligands [ion binding]; other site
509173003795	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
509173003796	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
509173003797	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
509173003798	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
509173003799	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
509173003800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173003801	S-adenosylmethionine binding site [chemical binding]; other site
509173003802	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
509173003803	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
509173003804	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173003805	S-adenosylmethionine binding site [chemical binding]; other site
509173003806	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
509173003807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173003808	dimer interface [polypeptide binding]; other site
509173003809	phosphorylation site [posttranslational modification]
509173003810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173003811	ATP binding site [chemical binding]; other site
509173003812	Mg2+ binding site [ion binding]; other site
509173003813	G-X-G motif; other site
509173003814	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
509173003815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173003816	active site
509173003817	phosphorylation site [posttranslational modification]
509173003818	intermolecular recognition site; other site
509173003819	dimerization interface [polypeptide binding]; other site
509173003820	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173003821	DNA binding site [nucleotide binding]
509173003822	SnoaL-like domain; Region: SnoaL_2; pfam12680
509173003823	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
509173003824	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
509173003825	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
509173003826	aspartate racemase; Region: asp_race; TIGR00035
509173003827	aromatic amino acid exporter; Provisional; Region: PRK11689
509173003828	EamA-like transporter family; Region: EamA; pfam00892
509173003829	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
509173003830	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173003831	Coenzyme A binding pocket [chemical binding]; other site
509173003832	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
509173003833	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173003834	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173003835	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
509173003836	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
509173003837	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
509173003838	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173003839	dimer interface [polypeptide binding]; other site
509173003840	conserved gate region; other site
509173003841	ABC-ATPase subunit interface; other site
509173003842	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
509173003843	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
509173003844	Walker A/P-loop; other site
509173003845	ATP binding site [chemical binding]; other site
509173003846	Q-loop/lid; other site
509173003847	ABC transporter signature motif; other site
509173003848	Walker B; other site
509173003849	D-loop; other site
509173003850	H-loop/switch region; other site
509173003851	NIL domain; Region: NIL; pfam09383
509173003852	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
509173003853	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
509173003854	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
509173003855	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
509173003856	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
509173003857	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
509173003858	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
509173003859	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
509173003860	purine monophosphate binding site [chemical binding]; other site
509173003861	dimer interface [polypeptide binding]; other site
509173003862	putative catalytic residues [active]
509173003863	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
509173003864	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
509173003865	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
509173003866	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
509173003867	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
509173003868	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
509173003869	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173003870	S-adenosylmethionine binding site [chemical binding]; other site
509173003871	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial)
509173003872	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
509173003873	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
509173003874	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
509173003875	Predicted transcriptional regulator [Transcription]; Region: COG2378
509173003876	WYL domain; Region: WYL; pfam13280
509173003877	Uncharacterized conserved protein [Function unknown]; Region: COG2308
509173003878	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
509173003879	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
509173003880	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
509173003881	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
509173003882	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
509173003883	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
509173003884	alanine racemase; Reviewed; Region: alr; PRK00053
509173003885	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
509173003886	active site
509173003887	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
509173003888	substrate binding site [chemical binding]; other site
509173003889	catalytic residues [active]
509173003890	dimer interface [polypeptide binding]; other site
509173003891	replicative DNA helicase; Region: DnaB; TIGR00665
509173003892	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
509173003893	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
509173003894	Walker A motif; other site
509173003895	ATP binding site [chemical binding]; other site
509173003896	Walker B motif; other site
509173003897	DNA binding loops [nucleotide binding]
509173003898	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
509173003899	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
509173003900	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
509173003901	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
509173003902	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
509173003903	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
509173003904	UbiA prenyltransferase family; Region: UbiA; pfam01040
509173003905	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
509173003906	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
509173003907	Subunit I/III interface [polypeptide binding]; other site
509173003908	Subunit III/IV interface [polypeptide binding]; other site
509173003909	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
509173003910	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
509173003911	D-pathway; other site
509173003912	Putative ubiquinol binding site [chemical binding]; other site
509173003913	Low-spin heme (heme b) binding site [chemical binding]; other site
509173003914	Putative water exit pathway; other site
509173003915	Binuclear center (heme o3/CuB) [ion binding]; other site
509173003916	K-pathway; other site
509173003917	Putative proton exit pathway; other site
509173003918	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
509173003919	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
509173003920	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
509173003921	RDD family; Region: RDD; pfam06271
509173003922	phosphoenolpyruvate synthase; Validated; Region: PRK06464
509173003923	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
509173003924	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
509173003925	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
509173003926	PEP synthetase regulatory protein; Provisional; Region: PRK05339
509173003927	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
509173003928	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
509173003929	binding surface
509173003930	TPR motif; other site
509173003931	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
509173003932	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
509173003933	putative active site [active]
509173003934	putative metal binding site [ion binding]; other site
509173003935	N-glycosyltransferase; Provisional; Region: PRK11204
509173003936	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
509173003937	DXD motif; other site
509173003938	PgaD-like protein; Region: PgaD; pfam13994
509173003939	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
509173003940	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
509173003941	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173003942	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173003943	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
509173003944	putative effector binding pocket; other site
509173003945	dimerization interface [polypeptide binding]; other site
509173003946	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
509173003947	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
509173003948	potential catalytic triad [active]
509173003949	conserved cys residue [active]
509173003950	peptide chain release factor 1; Validated; Region: prfA; PRK00591
509173003951	This domain is found in peptide chain release factors; Region: PCRF; smart00937
509173003952	RF-1 domain; Region: RF-1; pfam00472
509173003953	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
509173003954	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173003955	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
509173003956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173003957	ABC-ATPase subunit interface; other site
509173003958	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
509173003959	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
509173003960	substrate binding pocket [chemical binding]; other site
509173003961	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
509173003962	membrane-bound complex binding site; other site
509173003963	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173003964	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
509173003965	SurA N-terminal domain; Region: SurA_N; pfam09312
509173003966	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173003967	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
509173003968	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
509173003969	NAD binding site [chemical binding]; other site
509173003970	homodimer interface [polypeptide binding]; other site
509173003971	homotetramer interface [polypeptide binding]; other site
509173003972	active site
509173003973	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173003974	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173003975	active site
509173003976	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
509173003977	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
509173003978	acyl-activating enzyme (AAE) consensus motif; other site
509173003979	AMP binding site [chemical binding]; other site
509173003980	active site
509173003981	CoA binding site [chemical binding]; other site
509173003982	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
509173003983	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
509173003984	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
509173003985	ATP binding site [chemical binding]; other site
509173003986	substrate interface [chemical binding]; other site
509173003987	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
509173003988	ABC1 family; Region: ABC1; cl17513
509173003989	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
509173003990	homooctamer interface [polypeptide binding]; other site
509173003991	active site
509173003992	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
509173003993	catalytic center binding site [active]
509173003994	ATP binding site [chemical binding]; other site
509173003995	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
509173003996	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
509173003997	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
509173003998	Soluble P-type ATPase [General function prediction only]; Region: COG4087
509173003999	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
509173004000	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
509173004001	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
509173004002	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
509173004003	Ligand Binding Site [chemical binding]; other site
509173004004	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173004005	dimer interface [polypeptide binding]; other site
509173004006	phosphorylation site [posttranslational modification]
509173004007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173004008	ATP binding site [chemical binding]; other site
509173004009	Mg2+ binding site [ion binding]; other site
509173004010	G-X-G motif; other site
509173004011	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
509173004012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173004013	active site
509173004014	phosphorylation site [posttranslational modification]
509173004015	intermolecular recognition site; other site
509173004016	dimerization interface [polypeptide binding]; other site
509173004017	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173004018	DNA binding site [nucleotide binding]
509173004019	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
509173004020	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
509173004021	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
509173004022	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
509173004023	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
509173004024	diiron binding motif [ion binding]; other site
509173004025	lysophospholipid transporter LplT; Provisional; Region: PRK11195
509173004026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004027	putative substrate translocation pore; other site
509173004028	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
509173004029	Surface antigen; Region: Bac_surface_Ag; pfam01103
509173004030	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
509173004031	Family of unknown function (DUF490); Region: DUF490; pfam04357
509173004032	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
509173004033	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
509173004034	substrate binding site [chemical binding]; other site
509173004035	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
509173004036	substrate binding site [chemical binding]; other site
509173004037	ligand binding site [chemical binding]; other site
509173004038	Ion transport protein; Region: Ion_trans; pfam00520
509173004039	Ion channel; Region: Ion_trans_2; pfam07885
509173004040	CCC1-related family of proteins; Region: CCC1_like; cl00278
509173004041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004042	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173004043	putative substrate translocation pore; other site
509173004044	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
509173004045	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173004046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173004047	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
509173004048	putative dimerization interface [polypeptide binding]; other site
509173004049	Protein of unknown function (DUF441); Region: DUF441; pfam04284
509173004050	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
509173004051	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
509173004052	RNA binding surface [nucleotide binding]; other site
509173004053	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
509173004054	active site
509173004055	uracil binding [chemical binding]; other site
509173004056	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
509173004057	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173004058	Coenzyme A binding pocket [chemical binding]; other site
509173004059	RelB antitoxin; Region: RelB; cl01171
509173004060	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
509173004061	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
509173004062	probable active site [active]
509173004063	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
509173004064	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
509173004065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173004066	ATP binding site [chemical binding]; other site
509173004067	Mg2+ binding site [ion binding]; other site
509173004068	G-X-G motif; other site
509173004069	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
509173004070	ATP binding site [chemical binding]; other site
509173004071	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
509173004072	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
509173004073	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
509173004074	bacterial Hfq-like; Region: Hfq; cd01716
509173004075	hexamer interface [polypeptide binding]; other site
509173004076	Sm1 motif; other site
509173004077	RNA binding site [nucleotide binding]; other site
509173004078	Sm2 motif; other site
509173004079	EamA-like transporter family; Region: EamA; pfam00892
509173004080	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
509173004081	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
509173004082	dimer interface [polypeptide binding]; other site
509173004083	FMN binding site [chemical binding]; other site
509173004084	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
509173004085	putative active site [active]
509173004086	putative metal binding site [ion binding]; other site
509173004087	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
509173004088	substrate binding site [chemical binding]; other site
509173004089	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
509173004090	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
509173004091	active site
509173004092	HIGH motif; other site
509173004093	nucleotide binding site [chemical binding]; other site
509173004094	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
509173004095	KMSKS motif; other site
509173004096	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
509173004097	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
509173004098	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
509173004099	catalytic triad [active]
509173004100	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
509173004101	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
509173004102	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
509173004103	ethanolamine permease; Region: 2A0305; TIGR00908
509173004104	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
509173004105	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
509173004106	NAD(P) binding site [chemical binding]; other site
509173004107	catalytic residues [active]
509173004108	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
509173004109	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
509173004110	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173004111	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
509173004112	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
509173004113	dimer interface [polypeptide binding]; other site
509173004114	active site
509173004115	metal binding site [ion binding]; metal-binding site
509173004116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173004117	PIF1-like helicase; Region: PIF1; pfam05970
509173004118	Walker A motif; other site
509173004119	ATP binding site [chemical binding]; other site
509173004120	Walker B motif; other site
509173004121	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
509173004122	putative substrate binding pocket [chemical binding]; other site
509173004123	trimer interface [polypeptide binding]; other site
509173004124	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
509173004125	substrate binding site [chemical binding]; other site
509173004126	multimerization interface [polypeptide binding]; other site
509173004127	ATP binding site [chemical binding]; other site
509173004128	aminopeptidase N; Provisional; Region: pepN; PRK14015
509173004129	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
509173004130	active site
509173004131	Zn binding site [ion binding]; other site
509173004132	Spore Coat Protein U domain; Region: SCPU; pfam05229
509173004133	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
509173004134	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
509173004135	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
509173004136	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
509173004137	PapC C-terminal domain; Region: PapC_C; pfam13953
509173004138	Spore Coat Protein U domain; Region: SCPU; pfam05229
509173004139	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
509173004140	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
509173004141	C-terminal domain interface [polypeptide binding]; other site
509173004142	GSH binding site (G-site) [chemical binding]; other site
509173004143	dimer interface [polypeptide binding]; other site
509173004144	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
509173004145	N-terminal domain interface [polypeptide binding]; other site
509173004146	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173004147	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
509173004148	NAD(P) binding site [chemical binding]; other site
509173004149	active site
509173004150	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173004151	active site
509173004152	chorismate mutase; Provisional; Region: PRK08055
509173004153	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
509173004154	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173004155	putative DNA binding site [nucleotide binding]; other site
509173004156	putative Zn2+ binding site [ion binding]; other site
509173004157	AsnC family; Region: AsnC_trans_reg; pfam01037
509173004158	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173004159	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173004160	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
509173004161	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173004162	N-terminal plug; other site
509173004163	ligand-binding site [chemical binding]; other site
509173004164	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
509173004165	Mechanosensitive ion channel; Region: MS_channel; pfam00924
509173004166	synaptic vesicle protein SV2; Region: synapt_SV2; TIGR01299
509173004167	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173004168	Coenzyme A binding pocket [chemical binding]; other site
509173004169	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
509173004170	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173004171	N-terminal plug; other site
509173004172	ligand-binding site [chemical binding]; other site
509173004173	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
509173004174	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
509173004175	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173004176	Walker A/P-loop; other site
509173004177	ATP binding site [chemical binding]; other site
509173004178	Q-loop/lid; other site
509173004179	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
509173004180	ABC transporter signature motif; other site
509173004181	Walker B; other site
509173004182	D-loop; other site
509173004183	ABC transporter; Region: ABC_tran_2; pfam12848
509173004184	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
509173004185	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
509173004186	Ligand Binding Site [chemical binding]; other site
509173004187	dipeptidase, putative; Region: dipeptidaselike; TIGR01887
509173004188	RDD family; Region: RDD; pfam06271
509173004189	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
509173004190	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
509173004191	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
509173004192	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
509173004193	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
509173004194	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
509173004195	MgtC family; Region: MgtC; pfam02308
509173004196	Benzoate membrane transport protein; Region: BenE; pfam03594
509173004197	benzoate transporter; Region: benE; TIGR00843
509173004198	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
509173004199	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
509173004200	AsnC family; Region: AsnC_trans_reg; pfam01037
509173004201	leucine export protein LeuE; Provisional; Region: PRK10958
509173004202	transaldolase-like protein; Provisional; Region: PTZ00411
509173004203	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
509173004204	active site
509173004205	dimer interface [polypeptide binding]; other site
509173004206	catalytic residue [active]
509173004207	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173004208	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173004209	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
509173004210	dimerization interface [polypeptide binding]; other site
509173004211	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
509173004212	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
509173004213	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
509173004214	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
509173004215	dimer interface [polypeptide binding]; other site
509173004216	active site
509173004217	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
509173004218	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173004219	NAD(P) binding site [chemical binding]; other site
509173004220	active site
509173004221	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
509173004222	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
509173004223	active site 2 [active]
509173004224	active site 1 [active]
509173004225	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
509173004226	Beta-lactamase; Region: Beta-lactamase; pfam00144
509173004227	TetR family transcriptional regulator; Provisional; Region: PRK14996
509173004228	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173004229	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
509173004230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004231	putative substrate translocation pore; other site
509173004232	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960
509173004233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173004234	Walker A motif; other site
509173004235	ATP binding site [chemical binding]; other site
509173004236	Walker B motif; other site
509173004237	arginine finger; other site
509173004238	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
509173004239	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
509173004240	Phosphoesterase family; Region: Phosphoesterase; pfam04185
509173004241	Domain of unknown function (DUF756); Region: DUF756; pfam05506
509173004242	Domain of unknown function (DUF756); Region: DUF756; pfam05506
509173004243	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
509173004244	active site
509173004245	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
509173004246	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
509173004247	putative active site [active]
509173004248	metal binding site [ion binding]; metal-binding site
509173004249	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
509173004250	Low molecular weight phosphatase family; Region: LMWPc; cd00115
509173004251	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
509173004252	active site
509173004253	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
509173004254	FAD binding domain; Region: FAD_binding_4; pfam01565
509173004255	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
509173004256	Uncharacterized conserved protein [Function unknown]; Region: COG1434
509173004257	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
509173004258	putative active site [active]
509173004259	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
509173004260	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
509173004261	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
509173004262	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
509173004263	active site
509173004264	FMN binding site [chemical binding]; other site
509173004265	substrate binding site [chemical binding]; other site
509173004266	3Fe-4S cluster binding site [ion binding]; other site
509173004267	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
509173004268	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
509173004269	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173004270	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173004271	MFS_1 like family; Region: MFS_1_like; pfam12832
509173004272	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
509173004273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004274	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
509173004275	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
509173004276	ATP-grasp domain; Region: ATP-grasp_4; cl17255
509173004277	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
509173004278	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
509173004279	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
509173004280	carboxyltransferase (CT) interaction site; other site
509173004281	biotinylation site [posttranslational modification]; other site
509173004282	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
509173004283	Dehydroquinase class II; Region: DHquinase_II; pfam01220
509173004284	trimer interface [polypeptide binding]; other site
509173004285	active site
509173004286	dimer interface [polypeptide binding]; other site
509173004287	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
509173004288	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
509173004289	active site
509173004290	DNA binding site [nucleotide binding]
509173004291	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
509173004292	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
509173004293	NMT1-like family; Region: NMT1_2; pfam13379
509173004294	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
509173004295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173004296	active site
509173004297	phosphorylation site [posttranslational modification]
509173004298	intermolecular recognition site; other site
509173004299	dimerization interface [polypeptide binding]; other site
509173004300	ANTAR domain; Region: ANTAR; pfam03861
509173004301	nitrite reductase subunit NirD; Provisional; Region: PRK14989
509173004302	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173004303	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173004304	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
509173004305	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
509173004306	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
509173004307	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173004308	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
509173004309	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
509173004310	[4Fe-4S] binding site [ion binding]; other site
509173004311	molybdopterin cofactor binding site; other site
509173004312	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
509173004313	molybdopterin cofactor binding site; other site
509173004314	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
509173004315	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
509173004316	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
509173004317	GTP binding site; other site
509173004318	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
509173004319	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
509173004320	molybdopterin cofactor binding site; other site
509173004321	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
509173004322	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
509173004323	putative molybdopterin cofactor binding site; other site
509173004324	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
509173004325	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173004326	FeS/SAM binding site; other site
509173004327	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
509173004328	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
509173004329	MoaE homodimer interface [polypeptide binding]; other site
509173004330	MoaD interaction [polypeptide binding]; other site
509173004331	active site residues [active]
509173004332	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
509173004333	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
509173004334	trimer interface [polypeptide binding]; other site
509173004335	dimer interface [polypeptide binding]; other site
509173004336	putative active site [active]
509173004337	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
509173004338	MPT binding site; other site
509173004339	trimer interface [polypeptide binding]; other site
509173004340	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
509173004341	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
509173004342	dimer interface [polypeptide binding]; other site
509173004343	putative functional site; other site
509173004344	putative MPT binding site; other site
509173004345	Predicted transcriptional regulators [Transcription]; Region: COG1733
509173004346	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
509173004347	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173004348	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
509173004349	DNA-binding site [nucleotide binding]; DNA binding site
509173004350	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173004351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173004352	homodimer interface [polypeptide binding]; other site
509173004353	catalytic residue [active]
509173004354	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
509173004355	EamA-like transporter family; Region: EamA; pfam00892
509173004356	EamA-like transporter family; Region: EamA; pfam00892
509173004357	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
509173004358	DsrC like protein; Region: DsrC; pfam04358
509173004359	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
509173004360	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
509173004361	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173004362	NAD(P) binding site [chemical binding]; other site
509173004363	active site
509173004364	fumarate hydratase; Reviewed; Region: fumC; PRK00485
509173004365	Class II fumarases; Region: Fumarase_classII; cd01362
509173004366	active site
509173004367	tetramer interface [polypeptide binding]; other site
509173004368	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
509173004369	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
509173004370	hydroxyglutarate oxidase; Provisional; Region: PRK11728
509173004371	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
509173004372	homotrimer interaction site [polypeptide binding]; other site
509173004373	zinc binding site [ion binding]; other site
509173004374	CDP-binding sites; other site
509173004375	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
509173004376	catalytic residues [active]
509173004377	active site
509173004378	ornithine carbamoyltransferase; Provisional; Region: PRK00779
509173004379	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
509173004380	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
509173004381	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173004382	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173004383	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
509173004384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173004385	active site
509173004386	phosphorylation site [posttranslational modification]
509173004387	intermolecular recognition site; other site
509173004388	dimerization interface [polypeptide binding]; other site
509173004389	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173004390	Walker A motif; other site
509173004391	ATP binding site [chemical binding]; other site
509173004392	Walker B motif; other site
509173004393	arginine finger; other site
509173004394	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
509173004395	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
509173004396	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
509173004397	putative active site [active]
509173004398	heme pocket [chemical binding]; other site
509173004399	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173004400	dimer interface [polypeptide binding]; other site
509173004401	phosphorylation site [posttranslational modification]
509173004402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173004403	ATP binding site [chemical binding]; other site
509173004404	Mg2+ binding site [ion binding]; other site
509173004405	G-X-G motif; other site
509173004406	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
509173004407	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
509173004408	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173004409	FeS/SAM binding site; other site
509173004410	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
509173004411	putative nucleotide binding site [chemical binding]; other site
509173004412	uridine monophosphate binding site [chemical binding]; other site
509173004413	homohexameric interface [polypeptide binding]; other site
509173004414	ribosome recycling factor; Reviewed; Region: frr; PRK00083
509173004415	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
509173004416	hinge region; other site
509173004417	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
509173004418	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
509173004419	catalytic residue [active]
509173004420	putative FPP diphosphate  binding site; other site
509173004421	putative FPP binding hydrophobic cleft; other site
509173004422	dimer interface [polypeptide binding]; other site
509173004423	putative IPP diphosphate binding site; other site
509173004424	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
509173004425	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
509173004426	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
509173004427	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
509173004428	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
509173004429	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
509173004430	zinc metallopeptidase RseP; Provisional; Region: PRK10779
509173004431	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
509173004432	active site
509173004433	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
509173004434	protein binding site [polypeptide binding]; other site
509173004435	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
509173004436	protein binding site [polypeptide binding]; other site
509173004437	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
509173004438	putative substrate binding region [chemical binding]; other site
509173004439	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
509173004440	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
509173004441	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
509173004442	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
509173004443	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
509173004444	Surface antigen; Region: Bac_surface_Ag; pfam01103
509173004445	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
509173004446	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
509173004447	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
509173004448	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
509173004449	trimer interface [polypeptide binding]; other site
509173004450	active site
509173004451	UDP-GlcNAc binding site [chemical binding]; other site
509173004452	lipid binding site [chemical binding]; lipid-binding site
509173004453	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
509173004454	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
509173004455	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
509173004456	active site
509173004457	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
509173004458	recombination regulator RecX; Reviewed; Region: recX; PRK00117
509173004459	recombinase A; Provisional; Region: recA; PRK09354
509173004460	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
509173004461	hexamer interface [polypeptide binding]; other site
509173004462	Walker A motif; other site
509173004463	ATP binding site [chemical binding]; other site
509173004464	Walker B motif; other site
509173004465	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
509173004466	RNA binding surface [nucleotide binding]; other site
509173004467	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
509173004468	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
509173004469	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
509173004470	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
509173004471	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
509173004472	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
509173004473	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
509173004474	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173004475	putative DNA binding site [nucleotide binding]; other site
509173004476	putative Zn2+ binding site [ion binding]; other site
509173004477	AsnC family; Region: AsnC_trans_reg; pfam01037
509173004478	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
509173004479	kynureninase; Region: kynureninase; TIGR01814
509173004480	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
509173004481	catalytic residue [active]
509173004482	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
509173004483	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
509173004484	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
509173004485	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
509173004486	Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077
509173004487	calcium binding site 2 [ion binding]; other site
509173004488	active site
509173004489	catalytic triad [active]
509173004490	calcium binding site 1 [ion binding]; other site
509173004491	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
509173004492	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
509173004493	Sulfate transporter family; Region: Sulfate_transp; pfam00916
509173004494	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
509173004495	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
509173004496	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
509173004497	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
509173004498	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
509173004499	Ligand Binding Site [chemical binding]; other site
509173004500	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
509173004501	PAS domain; Region: PAS_9; pfam13426
509173004502	putative active site [active]
509173004503	heme pocket [chemical binding]; other site
509173004504	PAS fold; Region: PAS_4; pfam08448
509173004505	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
509173004506	putative active site [active]
509173004507	heme pocket [chemical binding]; other site
509173004508	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
509173004509	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
509173004510	metal binding site [ion binding]; metal-binding site
509173004511	active site
509173004512	I-site; other site
509173004513	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
509173004514	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
509173004515	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173004516	putative DNA binding site [nucleotide binding]; other site
509173004517	putative Zn2+ binding site [ion binding]; other site
509173004518	PEGA domain; Region: PEGA; pfam08308
509173004519	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
509173004520	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
509173004521	active site
509173004522	P-loop; other site
509173004523	phosphorylation site [posttranslational modification]
509173004524	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
509173004525	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
509173004526	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
509173004527	putative substrate binding site [chemical binding]; other site
509173004528	putative ATP binding site [chemical binding]; other site
509173004529	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
509173004530	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
509173004531	active site
509173004532	phosphorylation site [posttranslational modification]
509173004533	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
509173004534	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
509173004535	dimerization domain swap beta strand [polypeptide binding]; other site
509173004536	regulatory protein interface [polypeptide binding]; other site
509173004537	active site
509173004538	regulatory phosphorylation site [posttranslational modification]; other site
509173004539	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
509173004540	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
509173004541	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
509173004542	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
509173004543	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
509173004544	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
509173004545	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
509173004546	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
509173004547	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
509173004548	active site
509173004549	LysR family transcriptional regulator; Provisional; Region: PRK14997
509173004550	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173004551	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
509173004552	putative effector binding pocket; other site
509173004553	putative dimerization interface [polypeptide binding]; other site
509173004554	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
509173004555	putative GSH binding site [chemical binding]; other site
509173004556	catalytic residues [active]
509173004557	acetylornithine aminotransferase; Provisional; Region: PRK02627
509173004558	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
509173004559	inhibitor-cofactor binding pocket; inhibition site
509173004560	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173004561	catalytic residue [active]
509173004562	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
509173004563	FOG: CBS domain [General function prediction only]; Region: COG0517
509173004564	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
509173004565	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
509173004566	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
509173004567	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
509173004568	P loop; other site
509173004569	GTP binding site [chemical binding]; other site
509173004570	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
509173004571	dimer interface [polypeptide binding]; other site
509173004572	FMN binding site [chemical binding]; other site
509173004573	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
509173004574	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600
509173004575	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
509173004576	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
509173004577	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
509173004578	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
509173004579	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173004580	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173004581	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
509173004582	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
509173004583	iron-sulfur cluster [ion binding]; other site
509173004584	[2Fe-2S] cluster binding site [ion binding]; other site
509173004585	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
509173004586	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
509173004587	substrate binding site [chemical binding]; other site
509173004588	ATP binding site [chemical binding]; other site
509173004589	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
509173004590	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173004591	N-terminal plug; other site
509173004592	ligand-binding site [chemical binding]; other site
509173004593	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
509173004594	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
509173004595	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
509173004596	Peptidase M16C associated; Region: M16C_assoc; pfam08367
509173004597	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
509173004598	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
509173004599	dimerization interface [polypeptide binding]; other site
509173004600	substrate binding site [chemical binding]; other site
509173004601	active site
509173004602	calcium binding site [ion binding]; other site
509173004603	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
509173004604	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
509173004605	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
509173004606	TrkA-N domain; Region: TrkA_N; pfam02254
509173004607	threonine dehydratase; Reviewed; Region: PRK09224
509173004608	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
509173004609	tetramer interface [polypeptide binding]; other site
509173004610	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173004611	catalytic residue [active]
509173004612	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
509173004613	putative Ile/Val binding site [chemical binding]; other site
509173004614	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
509173004615	putative Ile/Val binding site [chemical binding]; other site
509173004616	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
509173004617	tetramer (dimer of dimers) interface [polypeptide binding]; other site
509173004618	active site
509173004619	dimer interface [polypeptide binding]; other site
509173004620	Protein of unknown function DUF45; Region: DUF45; pfam01863
509173004621	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
509173004622	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
509173004623	Uncharacterized conserved protein [Function unknown]; Region: COG2127
509173004624	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
509173004625	Clp amino terminal domain; Region: Clp_N; pfam02861
509173004626	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173004627	Walker A motif; other site
509173004628	ATP binding site [chemical binding]; other site
509173004629	Walker B motif; other site
509173004630	arginine finger; other site
509173004631	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173004632	Walker A motif; other site
509173004633	ATP binding site [chemical binding]; other site
509173004634	Walker B motif; other site
509173004635	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
509173004636	hypothetical protein; Provisional; Region: PRK02237
509173004637	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
509173004638	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
509173004639	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173004640	Predicted transcriptional regulators [Transcription]; Region: COG1695
509173004641	Transcriptional regulator PadR-like family; Region: PadR; cl17335
509173004642	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
509173004643	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
509173004644	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
509173004645	active site
509173004646	FMN binding site [chemical binding]; other site
509173004647	2,4-decadienoyl-CoA binding site; other site
509173004648	catalytic residue [active]
509173004649	4Fe-4S cluster binding site [ion binding]; other site
509173004650	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
509173004651	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
509173004652	SnoaL-like domain; Region: SnoaL_2; pfam12680
509173004653	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
509173004654	active site
509173004655	catalytic triad [active]
509173004656	oxyanion hole [active]
509173004657	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
509173004658	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
509173004659	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
509173004660	CTP synthetase; Validated; Region: pyrG; PRK05380
509173004661	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
509173004662	Catalytic site [active]
509173004663	active site
509173004664	UTP binding site [chemical binding]; other site
509173004665	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
509173004666	active site
509173004667	putative oxyanion hole; other site
509173004668	catalytic triad [active]
509173004669	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
509173004670	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
509173004671	enolase; Provisional; Region: eno; PRK00077
509173004672	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
509173004673	dimer interface [polypeptide binding]; other site
509173004674	metal binding site [ion binding]; metal-binding site
509173004675	substrate binding pocket [chemical binding]; other site
509173004676	Predicted membrane protein [Function unknown]; Region: COG2323
509173004677	Septum formation initiator; Region: DivIC; cl17659
509173004678	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
509173004679	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
509173004680	substrate binding site; other site
509173004681	dimer interface; other site
509173004682	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
509173004683	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
509173004684	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
509173004685	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
509173004686	dimer interface [polypeptide binding]; other site
509173004687	active site
509173004688	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
509173004689	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
509173004690	tetramer interface [polypeptide binding]; other site
509173004691	active site
509173004692	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
509173004693	benzoate transport; Region: 2A0115; TIGR00895
509173004694	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004695	putative substrate translocation pore; other site
509173004696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004697	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
509173004698	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
509173004699	heterodimer interface [polypeptide binding]; other site
509173004700	multimer interface [polypeptide binding]; other site
509173004701	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
509173004702	active site
509173004703	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
509173004704	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
509173004705	heterodimer interface [polypeptide binding]; other site
509173004706	active site
509173004707	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
509173004708	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
509173004709	active site
509173004710	catalytic residue [active]
509173004711	dimer interface [polypeptide binding]; other site
509173004712	Right handed beta helix region; Region: Beta_helix; pfam13229
509173004713	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
509173004714	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
509173004715	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
509173004716	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
509173004717	Trp docking motif [polypeptide binding]; other site
509173004718	putative active site [active]
509173004719	Predicted transporter component [General function prediction only]; Region: COG2391
509173004720	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
509173004721	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
509173004722	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
509173004723	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
509173004724	Bacterial transcriptional regulator; Region: IclR; pfam01614
509173004725	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173004726	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173004727	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
509173004728	substrate binding pocket [chemical binding]; other site
509173004729	dimerization interface [polypeptide binding]; other site
509173004730	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173004731	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173004732	active site
509173004733	thiamine kinase; Region: ycfN_thiK; TIGR02721
509173004734	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
509173004735	putative active site [active]
509173004736	putative substrate binding site [chemical binding]; other site
509173004737	ATP binding site [chemical binding]; other site
509173004738	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
509173004739	catalytic core [active]
509173004740	short chain dehydrogenase; Provisional; Region: PRK08251
509173004741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173004742	NAD(P) binding site [chemical binding]; other site
509173004743	active site
509173004744	outer membrane porin, OprD family; Region: OprD; pfam03573
509173004745	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004746	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173004747	putative substrate translocation pore; other site
509173004748	Transcriptional regulators [Transcription]; Region: MarR; COG1846
509173004749	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
509173004750	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
509173004751	Amidase; Region: Amidase; cl11426
509173004752	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173004753	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173004754	active site
509173004755	SnoaL-like domain; Region: SnoaL_4; pfam13577
509173004756	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
509173004757	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
509173004758	[2Fe-2S] cluster binding site [ion binding]; other site
509173004759	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
509173004760	putative alpha subunit interface [polypeptide binding]; other site
509173004761	putative active site [active]
509173004762	putative substrate binding site [chemical binding]; other site
509173004763	Fe binding site [ion binding]; other site
509173004764	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
509173004765	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
509173004766	classical (c) SDRs; Region: SDR_c; cd05233
509173004767	NAD(P) binding site [chemical binding]; other site
509173004768	active site
509173004769	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
509173004770	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
509173004771	FMN-binding pocket [chemical binding]; other site
509173004772	flavin binding motif; other site
509173004773	phosphate binding motif [ion binding]; other site
509173004774	beta-alpha-beta structure motif; other site
509173004775	NAD binding pocket [chemical binding]; other site
509173004776	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
509173004777	catalytic loop [active]
509173004778	iron binding site [ion binding]; other site
509173004779	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
509173004780	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
509173004781	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173004782	tyramine oxidase; Provisional; Region: tynA; PRK14696
509173004783	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
509173004784	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
509173004785	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
509173004786	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
509173004787	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
509173004788	NAD(P) binding site [chemical binding]; other site
509173004789	catalytic residues [active]
509173004790	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
509173004791	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
509173004792	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
509173004793	active site
509173004794	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
509173004795	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
509173004796	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
509173004797	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
509173004798	dimer interface [polypeptide binding]; other site
509173004799	active site
509173004800	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
509173004801	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
509173004802	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
509173004803	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
509173004804	dimer interface [polypeptide binding]; other site
509173004805	active site
509173004806	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
509173004807	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
509173004808	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
509173004809	octamer interface [polypeptide binding]; other site
509173004810	active site
509173004811	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
509173004812	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173004813	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173004814	dimerization interface [polypeptide binding]; other site
509173004815	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694
509173004816	Transcriptional regulators [Transcription]; Region: FadR; COG2186
509173004817	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173004818	DNA-binding site [nucleotide binding]; DNA binding site
509173004819	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
509173004820	dihydroxy-acid dehydratase; Validated; Region: PRK06131
509173004821	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
509173004822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004823	putative substrate translocation pore; other site
509173004824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
509173004826	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
509173004827	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
509173004828	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
509173004829	dimer interface [polypeptide binding]; other site
509173004830	NADP binding site [chemical binding]; other site
509173004831	catalytic residues [active]
509173004832	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173004833	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
509173004834	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
509173004835	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
509173004836	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
509173004837	putative active site [active]
509173004838	putative FMN binding site [chemical binding]; other site
509173004839	putative substrate binding site [chemical binding]; other site
509173004840	putative catalytic residue [active]
509173004841	Uncharacterized conserved protein [Function unknown]; Region: COG3268
509173004842	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173004843	NAD(P) binding site [chemical binding]; other site
509173004844	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
509173004845	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
509173004846	potential catalytic triad [active]
509173004847	conserved cys residue [active]
509173004848	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
509173004849	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
509173004850	DNA binding residues [nucleotide binding]
509173004851	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
509173004852	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
509173004853	potential catalytic triad [active]
509173004854	conserved cys residue [active]
509173004855	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
509173004856	Transcriptional regulator; Region: Rrf2; pfam02082
509173004857	Rrf2 family protein; Region: rrf2_super; TIGR00738
509173004858	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
509173004859	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
509173004860	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173004861	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173004862	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173004863	Helix-turn-helix domain; Region: HTH_18; pfam12833
509173004864	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173004865	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
509173004866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173004867	NAD(P) binding site [chemical binding]; other site
509173004868	active site
509173004869	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
509173004870	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
509173004871	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
509173004872	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
509173004873	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
509173004874	putative active site [active]
509173004875	putative FMN binding site [chemical binding]; other site
509173004876	putative substrate binding site [chemical binding]; other site
509173004877	putative catalytic residue [active]
509173004878	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
509173004879	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
509173004880	Uncharacterized conserved protein [Function unknown]; Region: COG1359
509173004881	Isochorismatase family; Region: Isochorismatase; pfam00857
509173004882	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
509173004883	catalytic triad [active]
509173004884	dimer interface [polypeptide binding]; other site
509173004885	conserved cis-peptide bond; other site
509173004886	LysR family transcriptional regulator; Provisional; Region: PRK14997
509173004887	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173004888	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
509173004889	putative effector binding pocket; other site
509173004890	putative dimerization interface [polypeptide binding]; other site
509173004891	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
509173004892	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
509173004893	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
509173004894	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
509173004895	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
509173004896	TrkA-N domain; Region: TrkA_N; pfam02254
509173004897	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
509173004898	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
509173004899	metal binding site [ion binding]; metal-binding site
509173004900	putative dimer interface [polypeptide binding]; other site
509173004901	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173004902	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173004903	Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763
509173004904	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
509173004905	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1)
509173004906	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173004907	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173004908	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2)
509173004909	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
509173004910	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004911	putative substrate translocation pore; other site
509173004912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004913	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
509173004914	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
509173004915	active site
509173004916	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
509173004917	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
509173004918	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
509173004919	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
509173004920	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173004921	DNA-binding site [nucleotide binding]; DNA binding site
509173004922	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
509173004923	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
509173004924	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
509173004925	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004926	putative substrate translocation pore; other site
509173004927	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173004928	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173004929	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173004930	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
509173004931	putative effector binding pocket; other site
509173004932	dimerization interface [polypeptide binding]; other site
509173004933	Protein of unknown function, DUF606; Region: DUF606; pfam04657
509173004934	Protein of unknown function, DUF606; Region: DUF606; pfam04657
509173004935	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
509173004936	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173004937	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173004938	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004939	putative substrate translocation pore; other site
509173004940	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173004941	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173004942	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
509173004943	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
509173004944	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
509173004945	dimer interface [polypeptide binding]; other site
509173004946	NADP binding site [chemical binding]; other site
509173004947	catalytic residues [active]
509173004948	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
509173004949	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
509173004950	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
509173004951	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173004952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173004953	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
509173004954	putative dimerization interface [polypeptide binding]; other site
509173004955	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
509173004956	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
509173004957	putative NAD(P) binding site [chemical binding]; other site
509173004958	active site
509173004959	putative substrate binding site [chemical binding]; other site
509173004960	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
509173004961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004962	putative substrate translocation pore; other site
509173004963	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
509173004964	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
509173004965	Evidence 7 : Gene remnant; Product type pr : regulator; fragment of  transcriptional regulator (AraC family)
509173004966	Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462
509173004967	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
509173004968	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
509173004969	active site
509173004970	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
509173004971	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
509173004972	active site
509173004973	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
509173004974	nudix motif; other site
509173004975	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
509173004976	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
509173004977	FAD binding site [chemical binding]; other site
509173004978	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
509173004979	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
509173004980	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
509173004981	DNA binding residues [nucleotide binding]
509173004982	dimerization interface [polypeptide binding]; other site
509173004983	indole acetimide hydrolase; Validated; Region: PRK07488
509173004984	Amidase; Region: Amidase; pfam01425
509173004985	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
509173004986	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173004987	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173004988	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
509173004989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004990	putative substrate translocation pore; other site
509173004991	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173004992	GH3 auxin-responsive promoter; Region: GH3; pfam03321
509173004993	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
509173004994	Survival protein SurE; Region: SurE; pfam01975
509173004995	HD domain; Region: HD_4; pfam13328
509173004996	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
509173004997	ATP binding site [chemical binding]; other site
509173004998	putative Mg++ binding site [ion binding]; other site
509173004999	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
509173005000	nucleotide binding region [chemical binding]; other site
509173005001	ATP-binding site [chemical binding]; other site
509173005002	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173005003	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173005004	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173005005	Coenzyme A binding pocket [chemical binding]; other site
509173005006	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
509173005007	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173005008	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173005009	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
509173005010	putative effector binding pocket; other site
509173005011	putative dimerization interface [polypeptide binding]; other site
509173005012	classical (c) SDRs; Region: SDR_c; cd05233
509173005013	NAD(P) binding site [chemical binding]; other site
509173005014	active site
509173005015	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
509173005016	classical (c) SDRs; Region: SDR_c; cd05233
509173005017	NAD(P) binding site [chemical binding]; other site
509173005018	active site
509173005019	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
509173005020	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173005021	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
509173005022	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173005023	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173005024	dimerization interface [polypeptide binding]; other site
509173005025	putative DNA binding site [nucleotide binding]; other site
509173005026	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173005027	putative Zn2+ binding site [ion binding]; other site
509173005028	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
509173005029	dimerization interface [polypeptide binding]; other site
509173005030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173005031	dimer interface [polypeptide binding]; other site
509173005032	phosphorylation site [posttranslational modification]
509173005033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173005034	ATP binding site [chemical binding]; other site
509173005035	Mg2+ binding site [ion binding]; other site
509173005036	G-X-G motif; other site
509173005037	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
509173005038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173005039	active site
509173005040	phosphorylation site [posttranslational modification]
509173005041	intermolecular recognition site; other site
509173005042	dimerization interface [polypeptide binding]; other site
509173005043	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173005044	DNA binding site [nucleotide binding]
509173005045	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
509173005046	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173005047	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173005048	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
509173005049	Protein export membrane protein; Region: SecD_SecF; cl14618
509173005050	Protein export membrane protein; Region: SecD_SecF; cl14618
509173005051	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
509173005052	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
509173005053	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
509173005054	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
509173005055	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
509173005056	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173005057	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173005058	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
509173005059	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
509173005060	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
509173005061	replication initiation protein; Region: II; PHA00360
509173005062	Phage replication protein CRI; Region: Phage_CRI; pfam05144
509173005063	Phage X family; Region: Phage_X; cl11585
509173005064	Zonular occludens toxin (Zot); Region: Zot; cl17485
509173005065	Protein of unknown function (DUF2523); Region: DUF2523; cl10291
509173005066	Bacteriophage coat protein B; Region: CoatB; pfam10389
509173005067	replication initiation protein; Region: II; PHA00360
509173005068	Phage replication protein CRI; Region: Phage_CRI; pfam05144
509173005069	Phage X family; Region: Phage_X; cl11585
509173005070	replication initiation protein; Region: II; PHA00360
509173005071	Phage replication protein CRI; Region: Phage_CRI; pfam05144
509173005072	Phage X family; Region: Phage_X; cl11585
509173005073	Zonular occludens toxin (Zot); Region: Zot; cl17485
509173005074	Protein of unknown function (DUF2523); Region: DUF2523; cl10291
509173005075	Bacteriophage coat protein B; Region: CoatB; pfam10389
509173005076	replication initiation protein; Region: II; PHA00360
509173005077	Phage replication protein CRI; Region: Phage_CRI; pfam05144
509173005078	Phage X family; Region: Phage_X; cl11585
509173005079	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
509173005080	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
509173005081	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
509173005082	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
509173005083	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
509173005084	PapC N-terminal domain; Region: PapC_N; pfam13954
509173005085	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
509173005086	PapC C-terminal domain; Region: PapC_C; pfam13953
509173005087	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
509173005088	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
509173005089	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
509173005090	substrate binding site [chemical binding]; other site
509173005091	catalytic Zn binding site [ion binding]; other site
509173005092	NAD binding site [chemical binding]; other site
509173005093	structural Zn binding site [ion binding]; other site
509173005094	dimer interface [polypeptide binding]; other site
509173005095	Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152
509173005096	putative heme binding pocket [chemical binding]; other site
509173005097	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173005098	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173005099	Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of  phospholipase D protein (part 1)
509173005100	Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of  phospholipase D protein (part 2)
509173005101	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173005102	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173005103	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
509173005104	putative active site [active]
509173005105	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
509173005106	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
509173005107	active site
509173005108	dimer interface [polypeptide binding]; other site
509173005109	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
509173005110	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173005111	FeS/SAM binding site; other site
509173005112	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
509173005113	pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079
509173005114	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
509173005115	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
509173005116	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
509173005117	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
509173005118	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of polyphosphate kinase (Polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase) (part 2)
509173005119	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of polyphosphate kinase (Polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase) (part 1)
509173005120	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
509173005121	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
509173005122	putative active site [active]
509173005123	putative metal binding site [ion binding]; other site
509173005124	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
509173005125	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
509173005126	metal binding site 2 [ion binding]; metal-binding site
509173005127	putative DNA binding helix; other site
509173005128	metal binding site 1 [ion binding]; metal-binding site
509173005129	dimer interface [polypeptide binding]; other site
509173005130	structural Zn2+ binding site [ion binding]; other site
509173005131	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
509173005132	hydrophobic substrate binding pocket; other site
509173005133	Isochorismatase family; Region: Isochorismatase; pfam00857
509173005134	active site
509173005135	conserved cis-peptide bond; other site
509173005136	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173005137	NAD(P) binding site [chemical binding]; other site
509173005138	active site
509173005139	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
509173005140	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173005141	Walker A/P-loop; other site
509173005142	ATP binding site [chemical binding]; other site
509173005143	Q-loop/lid; other site
509173005144	ABC transporter signature motif; other site
509173005145	Walker B; other site
509173005146	D-loop; other site
509173005147	H-loop/switch region; other site
509173005148	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
509173005149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173005150	dimer interface [polypeptide binding]; other site
509173005151	conserved gate region; other site
509173005152	putative PBP binding loops; other site
509173005153	ABC-ATPase subunit interface; other site
509173005154	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
509173005155	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
509173005156	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
509173005157	anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228
509173005158	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
509173005159	[2Fe-2S] cluster binding site [ion binding]; other site
509173005160	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
509173005161	putative alpha subunit interface [polypeptide binding]; other site
509173005162	putative active site [active]
509173005163	putative substrate binding site [chemical binding]; other site
509173005164	Fe binding site [ion binding]; other site
509173005165	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
509173005166	inter-subunit interface; other site
509173005167	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
509173005168	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
509173005169	catalytic loop [active]
509173005170	iron binding site [ion binding]; other site
509173005171	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
509173005172	FAD binding pocket [chemical binding]; other site
509173005173	FAD binding motif [chemical binding]; other site
509173005174	phosphate binding motif [ion binding]; other site
509173005175	beta-alpha-beta structure motif; other site
509173005176	NAD binding pocket [chemical binding]; other site
509173005177	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173005178	Helix-turn-helix domain; Region: HTH_18; pfam12833
509173005179	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173005180	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
509173005181	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
509173005182	short chain dehydrogenase; Provisional; Region: PRK08265
509173005183	classical (c) SDRs; Region: SDR_c; cd05233
509173005184	NAD(P) binding site [chemical binding]; other site
509173005185	active site
509173005186	Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of  carboxymethylenebutenolidase (Dienelactone hydrolase) (DLH) (part 2)
509173005187	Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of  carboxymethylenebutenolidase (Dienelactone hydrolase) (DLH) (part 1)
509173005188	benzoate transport; Region: 2A0115; TIGR00895
509173005189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173005190	putative substrate translocation pore; other site
509173005191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173005192	Helix-turn-helix domain; Region: HTH_18; pfam12833
509173005193	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173005194	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
509173005195	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173005196	NAD(P) binding site [chemical binding]; other site
509173005197	active site
509173005198	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
509173005199	fructuronate transporter; Provisional; Region: PRK10034; cl15264
509173005200	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173005201	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173005202	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
509173005203	putative dimerization interface [polypeptide binding]; other site
509173005204	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
509173005205	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
509173005206	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
509173005207	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
509173005208	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
509173005209	dimer interface [polypeptide binding]; other site
509173005210	active site
509173005211	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173005212	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173005213	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
509173005214	substrate binding pocket [chemical binding]; other site
509173005215	dimerization interface [polypeptide binding]; other site
509173005216	cell density-dependent motility repressor; Provisional; Region: PRK10082
509173005217	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173005218	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
509173005219	dimerization interface [polypeptide binding]; other site
509173005220	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
509173005221	Aspartase; Region: Aspartase; cd01357
509173005222	active sites [active]
509173005223	tetramer interface [polypeptide binding]; other site
509173005224	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
509173005225	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173005226	N-terminal plug; other site
509173005227	ligand-binding site [chemical binding]; other site
509173005228	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
509173005229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173005230	putative substrate translocation pore; other site
509173005231	Protein of unknown function (DUF971); Region: DUF971; pfam06155
509173005232	HEAT repeats; Region: HEAT_2; pfam13646
509173005233	HEAT repeats; Region: HEAT_2; pfam13646
509173005234	HEAT repeats; Region: HEAT_2; pfam13646
509173005235	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
509173005236	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
509173005237	Walker A/P-loop; other site
509173005238	ATP binding site [chemical binding]; other site
509173005239	Q-loop/lid; other site
509173005240	ABC transporter signature motif; other site
509173005241	Walker B; other site
509173005242	D-loop; other site
509173005243	H-loop/switch region; other site
509173005244	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
509173005245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173005246	dimer interface [polypeptide binding]; other site
509173005247	conserved gate region; other site
509173005248	putative PBP binding loops; other site
509173005249	ABC-ATPase subunit interface; other site
509173005250	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
509173005251	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
509173005252	substrate binding pocket [chemical binding]; other site
509173005253	membrane-bound complex binding site; other site
509173005254	Ferredoxin [Energy production and conversion]; Region: COG1146
509173005255	putative oxidoreductase; Provisional; Region: PRK08275
509173005256	L-aspartate oxidase; Provisional; Region: PRK06175
509173005257	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
509173005258	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
509173005259	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173005260	DNA-binding site [nucleotide binding]; DNA binding site
509173005261	UTRA domain; Region: UTRA; pfam07702
509173005262	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
509173005263	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
509173005264	Chromate transporter; Region: Chromate_transp; pfam02417
509173005265	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
509173005266	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
509173005267	Predicted transcriptional regulators [Transcription]; Region: COG1733
509173005268	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
509173005269	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173005270	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173005271	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173005272	EamA-like transporter family; Region: EamA; pfam00892
509173005273	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
509173005274	EamA-like transporter family; Region: EamA; pfam00892
509173005275	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
509173005276	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
509173005277	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
509173005278	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
509173005279	Putative phosphatase (DUF442); Region: DUF442; cl17385
509173005280	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
509173005281	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
509173005282	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
509173005283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173005284	Walker A motif; other site
509173005285	ATP binding site [chemical binding]; other site
509173005286	Walker B motif; other site
509173005287	arginine finger; other site
509173005288	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
509173005289	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
509173005290	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
509173005291	putative NAD(P) binding site [chemical binding]; other site
509173005292	catalytic Zn binding site [ion binding]; other site
509173005293	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
509173005294	acetoin reductases; Region: 23BDH; TIGR02415
509173005295	NAD binding site [chemical binding]; other site
509173005296	homotetramer interface [polypeptide binding]; other site
509173005297	homodimer interface [polypeptide binding]; other site
509173005298	active site
509173005299	substrate binding site [chemical binding]; other site
509173005300	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
509173005301	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173005302	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173005303	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
509173005304	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
509173005305	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
509173005306	E3 interaction surface; other site
509173005307	lipoyl attachment site [posttranslational modification]; other site
509173005308	e3 binding domain; Region: E3_binding; pfam02817
509173005309	e3 binding domain; Region: E3_binding; pfam02817
509173005310	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
509173005311	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
509173005312	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
509173005313	alpha subunit interface [polypeptide binding]; other site
509173005314	TPP binding site [chemical binding]; other site
509173005315	heterodimer interface [polypeptide binding]; other site
509173005316	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
509173005317	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
509173005318	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
509173005319	tetramer interface [polypeptide binding]; other site
509173005320	TPP-binding site [chemical binding]; other site
509173005321	heterodimer interface [polypeptide binding]; other site
509173005322	phosphorylation loop region [posttranslational modification]
509173005323	lipoyl synthase; Provisional; Region: PRK12928
509173005324	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173005325	FeS/SAM binding site; other site
509173005326	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
509173005327	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
509173005328	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
509173005329	metal binding site [ion binding]; metal-binding site
509173005330	active site
509173005331	I-site; other site
509173005332	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
509173005333	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
509173005334	Tetramer interface [polypeptide binding]; other site
509173005335	active site
509173005336	FMN-binding site [chemical binding]; other site
509173005337	HemK family putative methylases; Region: hemK_fam; TIGR00536
509173005338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173005339	S-adenosylmethionine binding site [chemical binding]; other site
509173005340	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
509173005341	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
509173005342	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173005343	catalytic residue [active]
509173005344	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2)
509173005345	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1)
509173005346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173005347	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
509173005348	Walker A motif; other site
509173005349	ATP binding site [chemical binding]; other site
509173005350	Walker B motif; other site
509173005351	arginine finger; other site
509173005352	YcgL domain; Region: YcgL; pfam05166
509173005353	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
509173005354	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
509173005355	catalytic site [active]
509173005356	putative active site [active]
509173005357	putative substrate binding site [chemical binding]; other site
509173005358	HRDC domain; Region: HRDC; pfam00570
509173005359	recombination protein RecR; Reviewed; Region: recR; PRK00076
509173005360	RecR protein; Region: RecR; pfam02132
509173005361	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
509173005362	putative active site [active]
509173005363	putative metal-binding site [ion binding]; other site
509173005364	tetramer interface [polypeptide binding]; other site
509173005365	hypothetical protein; Validated; Region: PRK00153
509173005366	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
509173005367	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
509173005368	homodimer interface [polypeptide binding]; other site
509173005369	substrate-cofactor binding pocket; other site
509173005370	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173005371	catalytic residue [active]
509173005372	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
509173005373	Methyltransferase domain; Region: Methyltransf_23; pfam13489
509173005374	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173005375	S-adenosylmethionine binding site [chemical binding]; other site
509173005376	TonB C terminal; Region: TonB_2; pfam13103
509173005377	TolA protein; Region: tolA_full; TIGR02794
509173005378	Uncharacterized conserved protein [Function unknown]; Region: COG3791
509173005379	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
509173005380	HIT family signature motif; other site
509173005381	catalytic residue [active]
509173005382	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
509173005383	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
509173005384	eyelet of channel; other site
509173005385	trimer interface [polypeptide binding]; other site
509173005386	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
509173005387	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
509173005388	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
509173005389	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
509173005390	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
509173005391	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173005392	N-terminal plug; other site
509173005393	ligand-binding site [chemical binding]; other site
509173005394	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
509173005395	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
509173005396	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
509173005397	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
509173005398	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
509173005399	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
509173005400	cobalamin synthase; Reviewed; Region: cobS; PRK00235
509173005401	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
509173005402	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
509173005403	catalytic core [active]
509173005404	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
509173005405	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
509173005406	putative dimer interface [polypeptide binding]; other site
509173005407	active site pocket [active]
509173005408	putative cataytic base [active]
509173005409	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
509173005410	homotrimer interface [polypeptide binding]; other site
509173005411	Walker A motif; other site
509173005412	GTP binding site [chemical binding]; other site
509173005413	Walker B motif; other site
509173005414	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
509173005415	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
509173005416	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
509173005417	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173005418	motif II; other site
509173005419	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
509173005420	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
509173005421	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
509173005422	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
509173005423	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
509173005424	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
509173005425	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173005426	N-terminal plug; other site
509173005427	ligand-binding site [chemical binding]; other site
509173005428	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
509173005429	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
509173005430	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
509173005431	IucA / IucC family; Region: IucA_IucC; pfam04183
509173005432	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
509173005433	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
509173005434	IucA / IucC family; Region: IucA_IucC; pfam04183
509173005435	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
509173005436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173005437	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173005438	putative substrate translocation pore; other site
509173005439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173005440	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
509173005441	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173005442	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
509173005443	IucA / IucC family; Region: IucA_IucC; pfam04183
509173005444	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
509173005445	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
509173005446	putative deacylase active site [active]
509173005447	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
509173005448	ABC1 family; Region: ABC1; cl17513
509173005449	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173005450	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173005451	active site
509173005452	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173005453	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173005454	active site
509173005455	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
509173005456	Fatty acid desaturase; Region: FA_desaturase; pfam00487
509173005457	Di-iron ligands [ion binding]; other site
509173005458	Cupin; Region: Cupin_6; pfam12852
509173005459	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173005460	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173005461	periplasmic folding chaperone; Provisional; Region: PRK10788
509173005462	SurA N-terminal domain; Region: SurA_N_3; cl07813
509173005463	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
509173005464	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
509173005465	IHF dimer interface [polypeptide binding]; other site
509173005466	IHF - DNA interface [nucleotide binding]; other site
509173005467	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
509173005468	Transcriptional regulator; Region: Rrf2; cl17282
509173005469	Rrf2 family protein; Region: rrf2_super; TIGR00738
509173005470	cysteine desulfurase; Provisional; Region: PRK14012
509173005471	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
509173005472	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
509173005473	catalytic residue [active]
509173005474	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
509173005475	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
509173005476	trimerization site [polypeptide binding]; other site
509173005477	active site
509173005478	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
509173005479	co-chaperone HscB; Provisional; Region: hscB; PRK05014
509173005480	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
509173005481	HSP70 interaction site [polypeptide binding]; other site
509173005482	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
509173005483	chaperone protein HscA; Provisional; Region: hscA; PRK05183
509173005484	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
509173005485	nucleotide binding site [chemical binding]; other site
509173005486	putative NEF/HSP70 interaction site [polypeptide binding]; other site
509173005487	SBD interface [polypeptide binding]; other site
509173005488	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
509173005489	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
509173005490	catalytic loop [active]
509173005491	iron binding site [ion binding]; other site
509173005492	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
509173005493	cyclase homology domain; Region: CHD; cd07302
509173005494	nucleotidyl binding site; other site
509173005495	metal binding site [ion binding]; metal-binding site
509173005496	dimer interface [polypeptide binding]; other site
509173005497	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
509173005498	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
509173005499	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
509173005500	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
509173005501	ATP binding site [chemical binding]; other site
509173005502	putative Mg++ binding site [ion binding]; other site
509173005503	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
509173005504	nucleotide binding region [chemical binding]; other site
509173005505	ATP-binding site [chemical binding]; other site
509173005506	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
509173005507	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
509173005508	GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041
509173005509	putative C-terminal domain interface [polypeptide binding]; other site
509173005510	putative GSH binding site (G-site) [chemical binding]; other site
509173005511	putative dimer interface [polypeptide binding]; other site
509173005512	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
509173005513	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
509173005514	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
509173005515	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
509173005516	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
509173005517	NAD binding site [chemical binding]; other site
509173005518	active site
509173005519	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
509173005520	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
509173005521	catalytic core [active]
509173005522	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
509173005523	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
509173005524	active site
509173005525	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
509173005526	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
509173005527	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
509173005528	Walker A/P-loop; other site
509173005529	ATP binding site [chemical binding]; other site
509173005530	Q-loop/lid; other site
509173005531	ABC transporter signature motif; other site
509173005532	Walker B; other site
509173005533	D-loop; other site
509173005534	H-loop/switch region; other site
509173005535	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
509173005536	Walker A/P-loop; other site
509173005537	ATP binding site [chemical binding]; other site
509173005538	Q-loop/lid; other site
509173005539	ABC transporter signature motif; other site
509173005540	Walker B; other site
509173005541	D-loop; other site
509173005542	H-loop/switch region; other site
509173005543	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
509173005544	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
509173005545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173005546	dimer interface [polypeptide binding]; other site
509173005547	conserved gate region; other site
509173005548	putative PBP binding loops; other site
509173005549	ABC-ATPase subunit interface; other site
509173005550	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
509173005551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173005552	dimer interface [polypeptide binding]; other site
509173005553	conserved gate region; other site
509173005554	putative PBP binding loops; other site
509173005555	ABC-ATPase subunit interface; other site
509173005556	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
509173005557	active site
509173005558	Zn binding site [ion binding]; other site
509173005559	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
509173005560	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
509173005561	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
509173005562	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
509173005563	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
509173005564	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173005565	N-terminal plug; other site
509173005566	ligand-binding site [chemical binding]; other site
509173005567	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
509173005568	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
509173005569	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
509173005570	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
509173005571	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
509173005572	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
509173005573	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
509173005574	malate synthase G; Provisional; Region: PRK02999
509173005575	active site
509173005576	Predicted ATPase [General function prediction only]; Region: COG1485
509173005577	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173005578	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173005579	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173005580	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
509173005581	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
509173005582	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
509173005583	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
509173005584	active site
509173005585	dimer interface [polypeptide binding]; other site
509173005586	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
509173005587	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
509173005588	IHF dimer interface [polypeptide binding]; other site
509173005589	IHF - DNA interface [nucleotide binding]; other site
509173005590	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
509173005591	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
509173005592	RNA binding site [nucleotide binding]; other site
509173005593	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
509173005594	RNA binding site [nucleotide binding]; other site
509173005595	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
509173005596	RNA binding site [nucleotide binding]; other site
509173005597	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
509173005598	RNA binding site [nucleotide binding]; other site
509173005599	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
509173005600	RNA binding site [nucleotide binding]; other site
509173005601	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
509173005602	RNA binding site [nucleotide binding]; other site
509173005603	cytidylate kinase; Provisional; Region: cmk; PRK00023
509173005604	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
509173005605	CMP-binding site; other site
509173005606	The sites determining sugar specificity; other site
509173005607	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
509173005608	putative hydrophobic ligand binding site [chemical binding]; other site
509173005609	protein interface [polypeptide binding]; other site
509173005610	gate; other site
509173005611	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
509173005612	nucleoside/Zn binding site; other site
509173005613	dimer interface [polypeptide binding]; other site
509173005614	catalytic motif [active]
509173005615	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
509173005616	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173005617	substrate binding site [chemical binding]; other site
509173005618	oxyanion hole (OAH) forming residues; other site
509173005619	trimer interface [polypeptide binding]; other site
509173005620	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
509173005621	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
509173005622	ligand binding site [chemical binding]; other site
509173005623	active site
509173005624	UGI interface [polypeptide binding]; other site
509173005625	catalytic site [active]
509173005626	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
509173005627	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
509173005628	type II secretion system protein J; Region: gspJ; TIGR01711
509173005629	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
509173005630	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
509173005631	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
509173005632	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173005633	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173005634	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
509173005635	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
509173005636	active site
509173005637	PilZ domain; Region: PilZ; cl01260
509173005638	DNA polymerase III subunit delta'; Validated; Region: PRK05707
509173005639	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
509173005640	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
509173005641	Ligand binding site; other site
509173005642	oligomer interface; other site
509173005643	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
509173005644	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
509173005645	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
509173005646	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
509173005647	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
509173005648	Walker A/P-loop; other site
509173005649	ATP binding site [chemical binding]; other site
509173005650	Q-loop/lid; other site
509173005651	ABC transporter signature motif; other site
509173005652	Walker B; other site
509173005653	D-loop; other site
509173005654	H-loop/switch region; other site
509173005655	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
509173005656	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
509173005657	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
509173005658	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
509173005659	ParB-like nuclease domain; Region: ParB; smart00470
509173005660	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
509173005661	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
509173005662	P-loop; other site
509173005663	Magnesium ion binding site [ion binding]; other site
509173005664	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
509173005665	Magnesium ion binding site [ion binding]; other site
509173005666	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
509173005667	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
509173005668	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
509173005669	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
509173005670	Substrate binding site; other site
509173005671	metal-binding site
509173005672	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
509173005673	Phosphotransferase enzyme family; Region: APH; pfam01636
509173005674	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
509173005675	OstA-like protein; Region: OstA; cl00844
509173005676	Organic solvent tolerance protein; Region: OstA_C; pfam04453
509173005677	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
509173005678	SurA N-terminal domain; Region: SurA_N; pfam09312
509173005679	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
509173005680	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
509173005681	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
509173005682	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
509173005683	intersubunit interface [polypeptide binding]; other site
509173005684	active site
509173005685	zinc binding site [ion binding]; other site
509173005686	Na+ binding site [ion binding]; other site
509173005687	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
509173005688	Phosphoglycerate kinase; Region: PGK; pfam00162
509173005689	substrate binding site [chemical binding]; other site
509173005690	hinge regions; other site
509173005691	ADP binding site [chemical binding]; other site
509173005692	catalytic site [active]
509173005693	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
509173005694	Maf-like protein; Region: Maf; pfam02545
509173005695	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
509173005696	active site
509173005697	dimer interface [polypeptide binding]; other site
509173005698	Cupin superfamily protein; Region: Cupin_4; pfam08007
509173005699	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173005700	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173005701	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173005702	dimerization interface [polypeptide binding]; other site
509173005703	putative DNA binding site [nucleotide binding]; other site
509173005704	putative Zn2+ binding site [ion binding]; other site
509173005705	serine/threonine transporter SstT; Provisional; Region: PRK13628
509173005706	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
509173005707	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
509173005708	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
509173005709	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
509173005710	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
509173005711	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
509173005712	Walker A/P-loop; other site
509173005713	ATP binding site [chemical binding]; other site
509173005714	Q-loop/lid; other site
509173005715	ABC transporter signature motif; other site
509173005716	Walker B; other site
509173005717	D-loop; other site
509173005718	H-loop/switch region; other site
509173005719	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
509173005720	putative active site [active]
509173005721	putative catalytic site [active]
509173005722	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173005723	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173005724	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173005725	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
509173005726	lipoyl attachment site [posttranslational modification]; other site
509173005727	NAD-dependent deacetylase; Provisional; Region: PRK00481
509173005728	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
509173005729	NAD+ binding site [chemical binding]; other site
509173005730	substrate binding site [chemical binding]; other site
509173005731	Zn binding site [ion binding]; other site
509173005732	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
509173005733	Na binding site [ion binding]; other site
509173005734	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
509173005735	AsnC family; Region: AsnC_trans_reg; pfam01037
509173005736	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
509173005737	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
509173005738	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
509173005739	Glutamate binding site [chemical binding]; other site
509173005740	NAD binding site [chemical binding]; other site
509173005741	catalytic residues [active]
509173005742	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
509173005743	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
509173005744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173005745	S-adenosylmethionine binding site [chemical binding]; other site
509173005746	Predicted periplasmic protein [Function unknown]; Region: COG3698
509173005747	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
509173005748	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
509173005749	Uncharacterized conserved protein [Function unknown]; Region: COG2353
509173005750	OsmC-like protein; Region: OsmC; pfam02566
509173005751	transketolase; Reviewed; Region: PRK12753
509173005752	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
509173005753	TPP-binding site [chemical binding]; other site
509173005754	dimer interface [polypeptide binding]; other site
509173005755	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
509173005756	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
509173005757	PYR/PP interface [polypeptide binding]; other site
509173005758	dimer interface [polypeptide binding]; other site
509173005759	TPP binding site [chemical binding]; other site
509173005760	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
509173005761	S-adenosylmethionine synthetase; Validated; Region: PRK05250
509173005762	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
509173005763	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
509173005764	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
509173005765	N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867
509173005766	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
509173005767	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
509173005768	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
509173005769	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
509173005770	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
509173005771	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173005772	non-specific DNA binding site [nucleotide binding]; other site
509173005773	salt bridge; other site
509173005774	sequence-specific DNA binding site [nucleotide binding]; other site
509173005775	Cupin domain; Region: Cupin_2; cl17218
509173005776	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
509173005777	active site
509173005778	putative DNA-binding cleft [nucleotide binding]; other site
509173005779	dimer interface [polypeptide binding]; other site
509173005780	putative carbohydrate kinase; Provisional; Region: PRK10565
509173005781	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
509173005782	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
509173005783	putative substrate binding site [chemical binding]; other site
509173005784	putative ATP binding site [chemical binding]; other site
509173005785	epoxyqueuosine reductase; Region: TIGR00276
509173005786	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
509173005787	biotin synthase; Provisional; Region: PRK15108
509173005788	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173005789	FeS/SAM binding site; other site
509173005790	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
509173005791	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
509173005792	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
509173005793	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
509173005794	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
509173005795	Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of  outer membrane usher protein (part 1)
509173005796	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173005797	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173005798	Evidence 7 : Gene remnant; Product type pm : membrane component; fragment of  outer membrane usher protein (part 2)
509173005799	putative major fimbrial protein SthE; Provisional; Region: PRK15292
509173005800	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
509173005801	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173005802	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173005803	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173005804	dimerization interface [polypeptide binding]; other site
509173005805	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
509173005806	EamA-like transporter family; Region: EamA; pfam00892
509173005807	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
509173005808	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
509173005809	Na binding site [ion binding]; other site
509173005810	Predicted membrane protein [Function unknown]; Region: COG4125
509173005811	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
509173005812	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
509173005813	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173005814	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173005815	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
509173005816	dimerization interface [polypeptide binding]; other site
509173005817	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
509173005818	active site
509173005819	Int/Topo IB signature motif; other site
509173005820	DNA binding site [nucleotide binding]
509173005821	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173005822	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173005823	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
509173005824	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
509173005825	putative acyl-acceptor binding pocket; other site
509173005826	hypothetical protein; Validated; Region: PRK00110
509173005827	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
509173005828	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173005829	putative DNA binding site [nucleotide binding]; other site
509173005830	putative Zn2+ binding site [ion binding]; other site
509173005831	AsnC family; Region: AsnC_trans_reg; pfam01037
509173005832	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
509173005833	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
509173005834	Walker A/P-loop; other site
509173005835	ATP binding site [chemical binding]; other site
509173005836	Q-loop/lid; other site
509173005837	ABC transporter signature motif; other site
509173005838	Walker B; other site
509173005839	D-loop; other site
509173005840	H-loop/switch region; other site
509173005841	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
509173005842	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173005843	dimer interface [polypeptide binding]; other site
509173005844	conserved gate region; other site
509173005845	putative PBP binding loops; other site
509173005846	ABC-ATPase subunit interface; other site
509173005847	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
509173005848	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173005849	dimer interface [polypeptide binding]; other site
509173005850	conserved gate region; other site
509173005851	putative PBP binding loops; other site
509173005852	ABC-ATPase subunit interface; other site
509173005853	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
509173005854	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
509173005855	substrate binding pocket [chemical binding]; other site
509173005856	membrane-bound complex binding site; other site
509173005857	hinge residues; other site
509173005858	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
509173005859	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
509173005860	C-terminal domain interface [polypeptide binding]; other site
509173005861	GSH binding site (G-site) [chemical binding]; other site
509173005862	dimer interface [polypeptide binding]; other site
509173005863	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
509173005864	N-terminal domain interface [polypeptide binding]; other site
509173005865	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
509173005866	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173005867	active site
509173005868	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
509173005869	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
509173005870	Flavin binding site [chemical binding]; other site
509173005871	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
509173005872	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
509173005873	active site
509173005874	non-prolyl cis peptide bond; other site
509173005875	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
509173005876	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
509173005877	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
509173005878	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
509173005879	Walker A/P-loop; other site
509173005880	ATP binding site [chemical binding]; other site
509173005881	Q-loop/lid; other site
509173005882	ABC transporter signature motif; other site
509173005883	Walker B; other site
509173005884	D-loop; other site
509173005885	H-loop/switch region; other site
509173005886	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
509173005887	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173005888	dimer interface [polypeptide binding]; other site
509173005889	conserved gate region; other site
509173005890	ABC-ATPase subunit interface; other site
509173005891	GTP-binding protein YchF; Reviewed; Region: PRK09601
509173005892	YchF GTPase; Region: YchF; cd01900
509173005893	G1 box; other site
509173005894	GTP/Mg2+ binding site [chemical binding]; other site
509173005895	Switch I region; other site
509173005896	G2 box; other site
509173005897	Switch II region; other site
509173005898	G3 box; other site
509173005899	G4 box; other site
509173005900	G5 box; other site
509173005901	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
509173005902	Predicted membrane protein [Function unknown]; Region: COG4539
509173005903	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
509173005904	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
509173005905	ligand binding site [chemical binding]; other site
509173005906	flexible hinge region; other site
509173005907	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
509173005908	putative switch regulator; other site
509173005909	non-specific DNA interactions [nucleotide binding]; other site
509173005910	DNA binding site [nucleotide binding]
509173005911	sequence specific DNA binding site [nucleotide binding]; other site
509173005912	putative cAMP binding site [chemical binding]; other site
509173005913	AzlC protein; Region: AzlC; cl00570
509173005914	putative L-valine exporter; Provisional; Region: PRK10408
509173005915	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
509173005916	trimer interface [polypeptide binding]; other site
509173005917	putative substrate binding pocket [chemical binding]; other site
509173005918	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
509173005919	active site 1 [active]
509173005920	dimer interface [polypeptide binding]; other site
509173005921	hexamer interface [polypeptide binding]; other site
509173005922	active site 2 [active]
509173005923	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
509173005924	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173005925	ATP-grasp domain; Region: ATP-grasp; pfam02222
509173005926	PII uridylyl-transferase; Provisional; Region: glnD; PRK00275
509173005927	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
509173005928	metal binding triad; other site
509173005929	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
509173005930	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
509173005931	Zn2+ binding site [ion binding]; other site
509173005932	Mg2+ binding site [ion binding]; other site
509173005933	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
509173005934	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
509173005935	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
509173005936	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173005937	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173005938	homodimer interface [polypeptide binding]; other site
509173005939	catalytic residue [active]
509173005940	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173005941	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
509173005942	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173005943	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173005944	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
509173005945	catalytic residues [active]
509173005946	dimer interface [polypeptide binding]; other site
509173005947	methionine sulfoxide reductase B; Provisional; Region: PRK00222
509173005948	SelR domain; Region: SelR; pfam01641
509173005949	aminotransferase AlaT; Validated; Region: PRK09265
509173005950	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173005951	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173005952	homodimer interface [polypeptide binding]; other site
509173005953	catalytic residue [active]
509173005954	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
509173005955	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
509173005956	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
509173005957	active site
509173005958	homodimer interface [polypeptide binding]; other site
509173005959	homotetramer interface [polypeptide binding]; other site
509173005960	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
509173005961	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
509173005962	putative active site [active]
509173005963	putative PHP Thumb interface [polypeptide binding]; other site
509173005964	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
509173005965	generic binding surface I; other site
509173005966	generic binding surface II; other site
509173005967	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
509173005968	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
509173005969	serine O-acetyltransferase; Region: cysE; TIGR01172
509173005970	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
509173005971	trimer interface [polypeptide binding]; other site
509173005972	active site
509173005973	substrate binding site [chemical binding]; other site
509173005974	CoA binding site [chemical binding]; other site
509173005975	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
509173005976	TPR motif; other site
509173005977	binding surface
509173005978	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173005979	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
509173005980	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
509173005981	catalytic residue [active]
509173005982	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
509173005983	catalytic residues [active]
509173005984	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173005985	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173005986	Chromate transporter; Region: Chromate_transp; pfam02417
509173005987	Chromate transporter; Region: Chromate_transp; pfam02417
509173005988	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173005989	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173005990	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
509173005991	putative dimerization interface [polypeptide binding]; other site
509173005992	putative substrate binding pocket [chemical binding]; other site
509173005993	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
509173005994	arsenical-resistance protein; Region: acr3; TIGR00832
509173005995	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173005996	dimerization interface [polypeptide binding]; other site
509173005997	putative DNA binding site [nucleotide binding]; other site
509173005998	putative Zn2+ binding site [ion binding]; other site
509173005999	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
509173006000	ArsC family; Region: ArsC; pfam03960
509173006001	catalytic residues [active]
509173006002	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein
509173006003	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
509173006004	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
509173006005	active site
509173006006	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
509173006007	Isochorismatase family; Region: Isochorismatase; pfam00857
509173006008	catalytic triad [active]
509173006009	dimer interface [polypeptide binding]; other site
509173006010	conserved cis-peptide bond; other site
509173006011	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173006012	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006013	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
509173006014	putative effector binding pocket; other site
509173006015	dimerization interface [polypeptide binding]; other site
509173006016	Transcriptional regulators [Transcription]; Region: GntR; COG1802
509173006017	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173006018	DNA-binding site [nucleotide binding]; DNA binding site
509173006019	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
509173006020	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
509173006021	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
509173006022	Na binding site [ion binding]; other site
509173006023	putative substrate binding site [chemical binding]; other site
509173006024	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
509173006025	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
509173006026	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
509173006027	active site
509173006028	iron coordination sites [ion binding]; other site
509173006029	substrate binding pocket [chemical binding]; other site
509173006030	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
509173006031	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173006032	dimer interface [polypeptide binding]; other site
509173006033	conserved gate region; other site
509173006034	putative PBP binding loops; other site
509173006035	ABC-ATPase subunit interface; other site
509173006036	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
509173006037	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
509173006038	Walker A/P-loop; other site
509173006039	ATP binding site [chemical binding]; other site
509173006040	Q-loop/lid; other site
509173006041	ABC transporter signature motif; other site
509173006042	Walker B; other site
509173006043	D-loop; other site
509173006044	H-loop/switch region; other site
509173006045	taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729
509173006046	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
509173006047	substrate binding pocket [chemical binding]; other site
509173006048	membrane-bound complex binding site; other site
509173006049	hinge residues; other site
509173006050	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
509173006051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006052	putative substrate translocation pore; other site
509173006053	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
509173006054	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
509173006055	active site
509173006056	non-prolyl cis peptide bond; other site
509173006057	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173006058	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
509173006059	active site
509173006060	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
509173006061	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
509173006062	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
509173006063	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
509173006064	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173006065	DNA-binding site [nucleotide binding]; DNA binding site
509173006066	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173006067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173006068	homodimer interface [polypeptide binding]; other site
509173006069	catalytic residue [active]
509173006070	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173006071	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006072	The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416
509173006073	putative dimerization interface [polypeptide binding]; other site
509173006074	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
509173006075	malonate transporter, MadL subunit; Region: malonate_madL; TIGR00807
509173006076	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
509173006077	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
509173006078	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
509173006079	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
509173006080	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
509173006081	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
509173006082	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
509173006083	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
509173006084	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
509173006085	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173006086	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006087	putative substrate translocation pore; other site
509173006088	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
509173006089	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
509173006090	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
509173006091	Evidence 7 : Gene remnant; Product type pr : regulator; fragment of  transcriptional regulator (GntR family) (part 1)
509173006092	Evidence 7 : Gene remnant; Product type pr : regulator; fragment of  transcriptional regulator (GntR family) (part 2)
509173006093	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
509173006094	LrgA family; Region: LrgA; cl00608
509173006095	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173006096	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006097	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
509173006098	putative dimerization interface [polypeptide binding]; other site
509173006099	glutathione S-transferase; Provisional; Region: PRK15113
509173006100	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
509173006101	C-terminal domain interface [polypeptide binding]; other site
509173006102	GSH binding site (G-site) [chemical binding]; other site
509173006103	dimer interface [polypeptide binding]; other site
509173006104	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
509173006105	putative dimer interface [polypeptide binding]; other site
509173006106	N-terminal domain interface [polypeptide binding]; other site
509173006107	putative substrate binding pocket (H-site) [chemical binding]; other site
509173006108	putative S-transferase; Provisional; Region: PRK11752
509173006109	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
509173006110	C-terminal domain interface [polypeptide binding]; other site
509173006111	GSH binding site (G-site) [chemical binding]; other site
509173006112	dimer interface [polypeptide binding]; other site
509173006113	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
509173006114	dimer interface [polypeptide binding]; other site
509173006115	N-terminal domain interface [polypeptide binding]; other site
509173006116	active site
509173006117	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173006118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006119	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
509173006120	putative effector binding pocket; other site
509173006121	putative dimerization interface [polypeptide binding]; other site
509173006122	short chain dehydrogenase; Provisional; Region: PRK12937
509173006123	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
509173006124	NADP binding site [chemical binding]; other site
509173006125	homodimer interface [polypeptide binding]; other site
509173006126	active site
509173006127	substrate binding site [chemical binding]; other site
509173006128	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
509173006129	active site residue [active]
509173006130	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
509173006131	trimer interface [polypeptide binding]; other site
509173006132	active site
509173006133	substrate binding site [chemical binding]; other site
509173006134	CoA binding site [chemical binding]; other site
509173006135	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
509173006136	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
509173006137	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
509173006138	catalytic residue [active]
509173006139	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173006140	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173006141	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006142	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
509173006143	putative effector binding pocket; other site
509173006144	dimerization interface [polypeptide binding]; other site
509173006145	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
509173006146	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
509173006147	substrate binding pocket [chemical binding]; other site
509173006148	membrane-bound complex binding site; other site
509173006149	hinge residues; other site
509173006150	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
509173006151	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
509173006152	substrate binding pocket [chemical binding]; other site
509173006153	membrane-bound complex binding site; other site
509173006154	hinge residues; other site
509173006155	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
509173006156	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
509173006157	Walker A/P-loop; other site
509173006158	ATP binding site [chemical binding]; other site
509173006159	Q-loop/lid; other site
509173006160	ABC transporter signature motif; other site
509173006161	Walker B; other site
509173006162	D-loop; other site
509173006163	H-loop/switch region; other site
509173006164	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173006165	dimer interface [polypeptide binding]; other site
509173006166	conserved gate region; other site
509173006167	putative PBP binding loops; other site
509173006168	ABC-ATPase subunit interface; other site
509173006169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173006170	dimer interface [polypeptide binding]; other site
509173006171	conserved gate region; other site
509173006172	ABC-ATPase subunit interface; other site
509173006173	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173006174	Coenzyme A binding pocket [chemical binding]; other site
509173006175	Response regulator receiver domain; Region: Response_reg; pfam00072
509173006176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173006177	active site
509173006178	phosphorylation site [posttranslational modification]
509173006179	intermolecular recognition site; other site
509173006180	dimerization interface [polypeptide binding]; other site
509173006181	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
509173006182	DNA binding residues [nucleotide binding]
509173006183	dimerization interface [polypeptide binding]; other site
509173006184	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
509173006185	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
509173006186	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173006187	dimer interface [polypeptide binding]; other site
509173006188	phosphorylation site [posttranslational modification]
509173006189	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173006190	ATP binding site [chemical binding]; other site
509173006191	Mg2+ binding site [ion binding]; other site
509173006192	G-X-G motif; other site
509173006193	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
509173006194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173006195	active site
509173006196	phosphorylation site [posttranslational modification]
509173006197	intermolecular recognition site; other site
509173006198	dimerization interface [polypeptide binding]; other site
509173006199	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
509173006200	Na binding site [ion binding]; other site
509173006201	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
509173006202	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173006203	putative DNA binding site [nucleotide binding]; other site
509173006204	putative Zn2+ binding site [ion binding]; other site
509173006205	AsnC family; Region: AsnC_trans_reg; pfam01037
509173006206	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173006207	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
509173006208	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
509173006209	Catalytic site [active]
509173006210	Evidence 7 : Gene remnant; Product type ph : phenotype; fragment of RecA-dependent DNA damage-inducible protein (partial)
509173006211	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
509173006212	short chain dehydrogenase; Provisional; Region: PRK06701
509173006213	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
509173006214	NAD binding site [chemical binding]; other site
509173006215	metal binding site [ion binding]; metal-binding site
509173006216	active site
509173006217	hydroperoxidase II; Provisional; Region: katE; PRK11249
509173006218	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
509173006219	tetramer interface [polypeptide binding]; other site
509173006220	heme binding pocket [chemical binding]; other site
509173006221	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
509173006222	domain interactions; other site
509173006223	Competence-damaged protein; Region: CinA; pfam02464
509173006224	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
509173006225	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173006226	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006227	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
509173006228	putative effector binding pocket; other site
509173006229	dimerization interface [polypeptide binding]; other site
509173006230	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
509173006231	active site
509173006232	catalytic triad [active]
509173006233	oxyanion hole [active]
509173006234	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
509173006235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173006236	S-adenosylmethionine binding site [chemical binding]; other site
509173006237	AMP-binding domain protein; Validated; Region: PRK08315
509173006238	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
509173006239	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
509173006240	acyl-activating enzyme (AAE) consensus motif; other site
509173006241	putative AMP binding site [chemical binding]; other site
509173006242	putative active site [active]
509173006243	putative CoA binding site [chemical binding]; other site
509173006244	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173006245	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173006246	isovaleryl-CoA dehydrogenase; Region: PLN02519
509173006247	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
509173006248	substrate binding site [chemical binding]; other site
509173006249	FAD binding site [chemical binding]; other site
509173006250	catalytic base [active]
509173006251	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
509173006252	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
509173006253	enoyl-CoA hydratase; Provisional; Region: PRK05995
509173006254	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173006255	substrate binding site [chemical binding]; other site
509173006256	oxyanion hole (OAH) forming residues; other site
509173006257	trimer interface [polypeptide binding]; other site
509173006258	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
509173006259	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
509173006260	ATP-grasp domain; Region: ATP-grasp_4; cl17255
509173006261	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
509173006262	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
509173006263	carboxyltransferase (CT) interaction site; other site
509173006264	biotinylation site [posttranslational modification]; other site
509173006265	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
509173006266	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
509173006267	active site
509173006268	catalytic residues [active]
509173006269	metal binding site [ion binding]; metal-binding site
509173006270	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173006271	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006272	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
509173006273	putative effector binding pocket; other site
509173006274	dimerization interface [polypeptide binding]; other site
509173006275	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
509173006276	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
509173006277	dimer interface [polypeptide binding]; other site
509173006278	PYR/PP interface [polypeptide binding]; other site
509173006279	TPP binding site [chemical binding]; other site
509173006280	substrate binding site [chemical binding]; other site
509173006281	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
509173006282	TPP-binding site [chemical binding]; other site
509173006283	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
509173006284	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
509173006285	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
509173006286	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
509173006287	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173006288	active site
509173006289	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
509173006290	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
509173006291	CoenzymeA binding site [chemical binding]; other site
509173006292	subunit interaction site [polypeptide binding]; other site
509173006293	PHB binding site; other site
509173006294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006295	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173006296	putative substrate translocation pore; other site
509173006297	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
509173006298	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
509173006299	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
509173006300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006301	benzoate transport; Region: 2A0115; TIGR00895
509173006302	putative substrate translocation pore; other site
509173006303	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173006304	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173006305	active site
509173006306	enoyl-CoA hydratase; Provisional; Region: PRK08138
509173006307	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173006308	substrate binding site [chemical binding]; other site
509173006309	oxyanion hole (OAH) forming residues; other site
509173006310	trimer interface [polypeptide binding]; other site
509173006311	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
509173006312	classical (c) SDRs; Region: SDR_c; cd05233
509173006313	NAD(P) binding site [chemical binding]; other site
509173006314	active site
509173006315	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
509173006316	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
509173006317	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
509173006318	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
509173006319	acetyl-CoA acetyltransferase; Provisional; Region: PRK08131
509173006320	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
509173006321	dimer interface [polypeptide binding]; other site
509173006322	active site
509173006323	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
509173006324	Transcriptional regulator [Transcription]; Region: IclR; COG1414
509173006325	Bacterial transcriptional regulator; Region: IclR; pfam01614
509173006326	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
509173006327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006328	putative substrate translocation pore; other site
509173006329	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
509173006330	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
509173006331	FMN binding site [chemical binding]; other site
509173006332	substrate binding site [chemical binding]; other site
509173006333	putative catalytic residue [active]
509173006334	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173006335	enoyl-CoA hydratase; Provisional; Region: PRK06688
509173006336	substrate binding site [chemical binding]; other site
509173006337	oxyanion hole (OAH) forming residues; other site
509173006338	trimer interface [polypeptide binding]; other site
509173006339	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
509173006340	Transcriptional regulator [Transcription]; Region: IclR; COG1414
509173006341	Bacterial transcriptional regulator; Region: IclR; pfam01614
509173006342	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
509173006343	CoA-transferase family III; Region: CoA_transf_3; pfam02515
509173006344	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173006345	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173006346	active site
509173006347	benzoate transport; Region: 2A0115; TIGR00895
509173006348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006349	putative substrate translocation pore; other site
509173006350	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
509173006351	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
509173006352	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
509173006353	catalytic residue [active]
509173006354	hydroxyglutarate oxidase; Provisional; Region: PRK11728
509173006355	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
509173006356	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
509173006357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173006358	dimer interface [polypeptide binding]; other site
509173006359	conserved gate region; other site
509173006360	putative PBP binding loops; other site
509173006361	ABC-ATPase subunit interface; other site
509173006362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173006363	dimer interface [polypeptide binding]; other site
509173006364	conserved gate region; other site
509173006365	putative PBP binding loops; other site
509173006366	ABC-ATPase subunit interface; other site
509173006367	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
509173006368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173006369	Walker A/P-loop; other site
509173006370	ATP binding site [chemical binding]; other site
509173006371	Q-loop/lid; other site
509173006372	ABC transporter signature motif; other site
509173006373	Walker B; other site
509173006374	D-loop; other site
509173006375	H-loop/switch region; other site
509173006376	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
509173006377	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
509173006378	transcriptional regulator protein; Region: phnR; TIGR03337
509173006379	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173006380	DNA-binding site [nucleotide binding]; DNA binding site
509173006381	UTRA domain; Region: UTRA; pfam07702
509173006382	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
509173006383	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
509173006384	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
509173006385	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
509173006386	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
509173006387	Bacterial transcriptional regulator; Region: IclR; pfam01614
509173006388	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
509173006389	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
509173006390	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173006391	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006392	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
509173006393	putative effector binding pocket; other site
509173006394	putative dimerization interface [polypeptide binding]; other site
509173006395	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
509173006396	succinic semialdehyde dehydrogenase; Region: PLN02278
509173006397	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
509173006398	tetramerization interface [polypeptide binding]; other site
509173006399	NAD(P) binding site [chemical binding]; other site
509173006400	catalytic residues [active]
509173006401	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
509173006402	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
509173006403	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
509173006404	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
509173006405	NAD(P) binding site [chemical binding]; other site
509173006406	catalytic residues [active]
509173006407	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
509173006408	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
509173006409	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
509173006410	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
509173006411	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
509173006412	Amino acid synthesis; Region: AA_synth; pfam06684
509173006413	Transcriptional regulators [Transcription]; Region: GntR; COG1802
509173006414	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173006415	DNA-binding site [nucleotide binding]; DNA binding site
509173006416	FCD domain; Region: FCD; cl11656
509173006417	Uncharacterized conserved protein [Function unknown]; Region: COG5470
509173006418	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
509173006419	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
509173006420	putative heme binding pocket [chemical binding]; other site
509173006421	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
509173006422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006423	putative substrate translocation pore; other site
509173006424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006425	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
509173006426	active site
509173006427	catalytic residues [active]
509173006428	metal binding site [ion binding]; metal-binding site
509173006429	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
509173006430	CoA-transferase family III; Region: CoA_transf_3; pfam02515
509173006431	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173006432	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006433	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
509173006434	putative dimerization interface [polypeptide binding]; other site
509173006435	Evidence 7 : Gene remnant; Product type pr : regulator; fragment of  transcriptional regulator (TetR family)
509173006436	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173006437	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173006438	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
509173006439	DNA-binding site [nucleotide binding]; DNA binding site
509173006440	RNA-binding motif; other site
509173006441	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173006442	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173006443	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
509173006444	Part of AAA domain; Region: AAA_19; pfam13245
509173006445	Family description; Region: UvrD_C_2; pfam13538
509173006446	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
509173006447	AAA ATPase domain; Region: AAA_15; pfam13175
509173006448	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
509173006449	putative active site [active]
509173006450	putative metal-binding site [ion binding]; other site
509173006451	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
509173006452	CoenzymeA binding site [chemical binding]; other site
509173006453	subunit interaction site [polypeptide binding]; other site
509173006454	PHB binding site; other site
509173006455	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
509173006456	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
509173006457	putative trimer interface [polypeptide binding]; other site
509173006458	putative metal binding site [ion binding]; other site
509173006459	PaaX-like protein; Region: PaaX; pfam07848
509173006460	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
509173006461	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
509173006462	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
509173006463	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
509173006464	acyl-activating enzyme (AAE) consensus motif; other site
509173006465	AMP binding site [chemical binding]; other site
509173006466	active site
509173006467	CoA binding site [chemical binding]; other site
509173006468	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
509173006469	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
509173006470	dimer interface [polypeptide binding]; other site
509173006471	active site
509173006472	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
509173006473	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
509173006474	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
509173006475	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
509173006476	enoyl-CoA hydratase; Provisional; Region: PRK08140
509173006477	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173006478	substrate binding site [chemical binding]; other site
509173006479	oxyanion hole (OAH) forming residues; other site
509173006480	trimer interface [polypeptide binding]; other site
509173006481	enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674
509173006482	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173006483	substrate binding site [chemical binding]; other site
509173006484	oxyanion hole (OAH) forming residues; other site
509173006485	trimer interface [polypeptide binding]; other site
509173006486	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
509173006487	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
509173006488	FAD binding pocket [chemical binding]; other site
509173006489	FAD binding motif [chemical binding]; other site
509173006490	phosphate binding motif [ion binding]; other site
509173006491	beta-alpha-beta structure motif; other site
509173006492	NAD(p) ribose binding residues [chemical binding]; other site
509173006493	NAD binding pocket [chemical binding]; other site
509173006494	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
509173006495	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
509173006496	catalytic loop [active]
509173006497	iron binding site [ion binding]; other site
509173006498	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
509173006499	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
509173006500	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
509173006501	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
509173006502	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
509173006503	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
509173006504	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
509173006505	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
509173006506	substrate binding site [chemical binding]; other site
509173006507	dimer interface [polypeptide binding]; other site
509173006508	NADP binding site [chemical binding]; other site
509173006509	catalytic residues [active]
509173006510	MaoC_C  The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452
509173006511	substrate binding site [chemical binding]; other site
509173006512	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
509173006513	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
509173006514	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
509173006515	amino acid transporter; Region: 2A0306; TIGR00909
509173006516	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
509173006517	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
509173006518	dimer interface [polypeptide binding]; other site
509173006519	NADP binding site [chemical binding]; other site
509173006520	catalytic residues [active]
509173006521	metabolite-proton symporter; Region: 2A0106; TIGR00883
509173006522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006523	putative substrate translocation pore; other site
509173006524	PAS fold; Region: PAS_4; pfam08448
509173006525	Helix-turn-helix domain; Region: HTH_18; pfam12833
509173006526	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173006527	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
509173006528	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
509173006529	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
509173006530	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
509173006531	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
509173006532	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
509173006533	Transcriptional regulators [Transcription]; Region: GntR; COG1802
509173006534	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173006535	DNA-binding site [nucleotide binding]; DNA binding site
509173006536	FCD domain; Region: FCD; pfam07729
509173006537	EamA-like transporter family; Region: EamA; pfam00892
509173006538	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
509173006539	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
509173006540	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
509173006541	inhibitor site; inhibition site
509173006542	active site
509173006543	dimer interface [polypeptide binding]; other site
509173006544	catalytic residue [active]
509173006545	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
509173006546	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
509173006547	Domain of unknown function (DUF333); Region: DUF333; pfam03891
509173006548	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
509173006549	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
509173006550	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
509173006551	DNA binding residues [nucleotide binding]
509173006552	dimer interface [polypeptide binding]; other site
509173006553	[2Fe-2S] cluster binding site [ion binding]; other site
509173006554	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
509173006555	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
509173006556	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173006557	Coenzyme A binding pocket [chemical binding]; other site
509173006558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
509173006559	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
509173006560	putative cyanate transporter; Provisional; Region: cynX; PRK09705
509173006561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006562	putative substrate translocation pore; other site
509173006563	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
509173006564	nucleoside/Zn binding site; other site
509173006565	dimer interface [polypeptide binding]; other site
509173006566	catalytic motif [active]
509173006567	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
509173006568	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
509173006569	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
509173006570	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
509173006571	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173006572	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006573	LysR substrate binding domain; Region: LysR_substrate; pfam03466
509173006574	dimerization interface [polypeptide binding]; other site
509173006575	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
509173006576	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
509173006577	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
509173006578	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
509173006579	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
509173006580	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
509173006581	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
509173006582	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
509173006583	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173006584	Walker A motif; other site
509173006585	ATP binding site [chemical binding]; other site
509173006586	Walker B motif; other site
509173006587	arginine finger; other site
509173006588	JNK_SAPK-associated protein-1; Region: Jnk-SapK_ap_N; pfam09744
509173006589	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173006590	Walker A motif; other site
509173006591	ATP binding site [chemical binding]; other site
509173006592	Walker B motif; other site
509173006593	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
509173006594	PAAR motif; Region: PAAR_motif; pfam05488
509173006595	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
509173006596	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
509173006597	ligand binding site [chemical binding]; other site
509173006598	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
509173006599	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
509173006600	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
509173006601	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
509173006602	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
509173006603	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
509173006604	Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462
509173006605	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
509173006606	Protein of unknown function (DUF796); Region: DUF796; pfam05638
509173006607	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
509173006608	Protein of unknown function (DUF877); Region: DUF877; pfam05943
509173006609	Protein of unknown function (DUF770); Region: DUF770; pfam05591
509173006610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
509173006611	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
509173006612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173006613	dimer interface [polypeptide binding]; other site
509173006614	conserved gate region; other site
509173006615	putative PBP binding loops; other site
509173006616	ABC-ATPase subunit interface; other site
509173006617	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
509173006618	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
509173006619	Walker A/P-loop; other site
509173006620	ATP binding site [chemical binding]; other site
509173006621	Q-loop/lid; other site
509173006622	ABC transporter signature motif; other site
509173006623	Walker B; other site
509173006624	D-loop; other site
509173006625	H-loop/switch region; other site
509173006626	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
509173006627	allophanate hydrolase; Provisional; Region: PRK08186
509173006628	Amidase; Region: Amidase; pfam01425
509173006629	nickel responsive regulator; Provisional; Region: PRK04460
509173006630	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
509173006631	Predicted transcriptional regulators [Transcription]; Region: COG1733
509173006632	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173006633	putative DNA binding site [nucleotide binding]; other site
509173006634	putative Zn2+ binding site [ion binding]; other site
509173006635	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
509173006636	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
509173006637	carboxyltransferase (CT) interaction site; other site
509173006638	biotinylation site [posttranslational modification]; other site
509173006639	urea carboxylase; Region: urea_carbox; TIGR02712
509173006640	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
509173006641	ATP-grasp domain; Region: ATP-grasp_4; cl17255
509173006642	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
509173006643	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
509173006644	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
509173006645	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
509173006646	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
509173006647	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
509173006648	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
509173006649	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
509173006650	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
509173006651	NAD binding site [chemical binding]; other site
509173006652	catalytic Zn binding site [ion binding]; other site
509173006653	structural Zn binding site [ion binding]; other site
509173006654	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
509173006655	putative hydrophobic ligand binding site [chemical binding]; other site
509173006656	protein interface [polypeptide binding]; other site
509173006657	gate; other site
509173006658	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173006659	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173006660	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
509173006661	Sel1-like repeats; Region: SEL1; smart00671
509173006662	Sel1-like repeats; Region: SEL1; smart00671
509173006663	Sel1-like repeats; Region: SEL1; smart00671
509173006664	Sel1-like repeats; Region: SEL1; smart00671
509173006665	Sel1-like repeats; Region: SEL1; smart00671
509173006666	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
509173006667	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
509173006668	putative Cl- selectivity filter; other site
509173006669	putative pore gating glutamate residue; other site
509173006670	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
509173006671	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
509173006672	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
509173006673	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
509173006674	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
509173006675	carboxyltransferase (CT) interaction site; other site
509173006676	biotinylation site [posttranslational modification]; other site
509173006677	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
509173006678	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
509173006679	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
509173006680	hypothetical protein; Provisional; Region: PRK05463
509173006681	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
509173006682	putative active site [active]
509173006683	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
509173006684	transcriptional regulator, ArgP family; Region: argP; TIGR03298
509173006685	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006686	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
509173006687	dimerization interface [polypeptide binding]; other site
509173006688	RHS protein; Region: RHS; pfam03527
509173006689	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
509173006690	Evidence 7 : Gene remnant; fragment of  Rhs family protein (part 2)
509173006691	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173006692	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173006693	Evidence 7 : Gene remnant; fragment of  Rhs family protein (part 1)
509173006694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
509173006695	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
509173006696	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
509173006697	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
509173006698	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
509173006699	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
509173006700	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
509173006701	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
509173006702	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
509173006703	BNR repeat-like domain; Region: BNR_2; pfam13088
509173006704	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
509173006705	benzoate transport; Region: 2A0115; TIGR00895
509173006706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006707	putative substrate translocation pore; other site
509173006708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006709	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173006710	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173006711	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
509173006712	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
509173006713	putative acyl-acceptor binding pocket; other site
509173006714	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
509173006715	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
509173006716	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173006717	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173006718	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
509173006719	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
509173006720	AsnC family; Region: AsnC_trans_reg; pfam01037
509173006721	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
509173006722	MutS domain I; Region: MutS_I; pfam01624
509173006723	MutS domain II; Region: MutS_II; pfam05188
509173006724	MutS domain III; Region: MutS_III; pfam05192
509173006725	MutS domain V; Region: MutS_V; pfam00488
509173006726	Walker A/P-loop; other site
509173006727	ATP binding site [chemical binding]; other site
509173006728	Q-loop/lid; other site
509173006729	ABC transporter signature motif; other site
509173006730	Walker B; other site
509173006731	D-loop; other site
509173006732	H-loop/switch region; other site
509173006733	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
509173006734	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173006735	Coenzyme A binding pocket [chemical binding]; other site
509173006736	Ferredoxin [Energy production and conversion]; Region: COG1146
509173006737	4Fe-4S binding domain; Region: Fer4; cl02805
509173006738	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
509173006739	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
509173006740	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
509173006741	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
509173006742	S-adenosylmethionine binding site [chemical binding]; other site
509173006743	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
509173006744	Ligand Binding Site [chemical binding]; other site
509173006745	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
509173006746	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
509173006747	putative trimer interface [polypeptide binding]; other site
509173006748	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
509173006749	trimer interface [polypeptide binding]; other site
509173006750	active site
509173006751	substrate binding site [chemical binding]; other site
509173006752	putative CoA binding site [chemical binding]; other site
509173006753	CoA binding site [chemical binding]; other site
509173006754	Uncharacterized conserved protein [Function unknown]; Region: COG1739
509173006755	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
509173006756	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
509173006757	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173006758	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173006759	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
509173006760	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
509173006761	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
509173006762	Walker A/P-loop; other site
509173006763	ATP binding site [chemical binding]; other site
509173006764	Q-loop/lid; other site
509173006765	ABC transporter signature motif; other site
509173006766	Walker B; other site
509173006767	D-loop; other site
509173006768	H-loop/switch region; other site
509173006769	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
509173006770	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
509173006771	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
509173006772	Walker A/P-loop; other site
509173006773	ATP binding site [chemical binding]; other site
509173006774	Q-loop/lid; other site
509173006775	ABC transporter signature motif; other site
509173006776	Walker B; other site
509173006777	D-loop; other site
509173006778	H-loop/switch region; other site
509173006779	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
509173006780	OstA-like protein; Region: OstA; pfam03968
509173006781	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
509173006782	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
509173006783	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
509173006784	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173006785	active site
509173006786	motif I; other site
509173006787	motif II; other site
509173006788	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
509173006789	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
509173006790	putative active site [active]
509173006791	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
509173006792	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
509173006793	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
509173006794	active site
509173006795	HIGH motif; other site
509173006796	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
509173006797	KMSKS motif; other site
509173006798	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
509173006799	tRNA binding surface [nucleotide binding]; other site
509173006800	anticodon binding site; other site
509173006801	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
509173006802	active site
509173006803	DNA binding site [nucleotide binding]
509173006804	Int/Topo IB signature motif; other site
509173006805	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
509173006806	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
509173006807	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
509173006808	Evidence 4 : Homologs of previously reported genes of unknown function; fragment of conserved hypothetical protein
509173006809	Evidence 4 : Homologs of previously reported genes of unknown function; fragment of conserved hypothetical protein
509173006810	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
509173006811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566
509173006812	Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293
509173006813	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
509173006814	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
509173006815	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
509173006816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
509173006817	Terminase-like family; Region: Terminase_6; pfam03237
509173006818	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
509173006819	Uncharacterized conserved protein (DUF2280); Region: DUF2280; cl02353
509173006820	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
509173006821	Predicted transcriptional regulators [Transcription]; Region: COG1733
509173006822	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
509173006823	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
509173006824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006825	putative substrate translocation pore; other site
509173006826	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
509173006827	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
509173006828	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
509173006829	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
509173006830	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
509173006831	DNA-binding site [nucleotide binding]; DNA binding site
509173006832	RNA-binding motif; other site
509173006833	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173006834	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
509173006835	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
509173006836	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173006837	Predicted transcriptional regulator [Transcription]; Region: COG2932
509173006838	non-specific DNA binding site [nucleotide binding]; other site
509173006839	salt bridge; other site
509173006840	sequence-specific DNA binding site [nucleotide binding]; other site
509173006841	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
509173006842	Catalytic site [active]
509173006843	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
509173006844	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
509173006845	generic binding surface II; other site
509173006846	generic binding surface I; other site
509173006847	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173006848	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
509173006849	dimerization interface [polypeptide binding]; other site
509173006850	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
509173006851	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
509173006852	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
509173006853	DNA binding residues [nucleotide binding]
509173006854	dimer interface [polypeptide binding]; other site
509173006855	copper binding site [ion binding]; other site
509173006856	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
509173006857	metal-binding site [ion binding]
509173006858	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
509173006859	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
509173006860	metal-binding site [ion binding]
509173006861	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
509173006862	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173006863	motif II; other site
509173006864	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
509173006865	metal-binding site [ion binding]
509173006866	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
509173006867	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173006868	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
509173006869	dimerizarion interface [polypeptide binding]; other site
509173006870	CrgA pocket; other site
509173006871	substrate binding pocket [chemical binding]; other site
509173006872	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
509173006873	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
509173006874	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
509173006875	putative alpha subunit interface [polypeptide binding]; other site
509173006876	putative active site [active]
509173006877	putative substrate binding site [chemical binding]; other site
509173006878	Fe binding site [ion binding]; other site
509173006879	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
509173006880	inter-subunit interface; other site
509173006881	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
509173006882	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
509173006883	catalytic loop [active]
509173006884	iron binding site [ion binding]; other site
509173006885	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
509173006886	FAD binding pocket [chemical binding]; other site
509173006887	FAD binding motif [chemical binding]; other site
509173006888	phosphate binding motif [ion binding]; other site
509173006889	beta-alpha-beta structure motif; other site
509173006890	NAD binding pocket [chemical binding]; other site
509173006891	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
509173006892	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937
509173006893	putative NAD(P) binding site [chemical binding]; other site
509173006894	active site
509173006895	benzoate transporter; Region: benE; TIGR00843
509173006896	Benzoate membrane transport protein; Region: BenE; pfam03594
509173006897	benzoate transport; Region: 2A0115; TIGR00895
509173006898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006899	putative substrate translocation pore; other site
509173006900	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173006901	putative substrate translocation pore; other site
509173006902	outer membrane porin, OprD family; Region: OprD; pfam03573
509173006903	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
509173006904	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
509173006905	dimer interface [polypeptide binding]; other site
509173006906	active site
509173006907	CoA binding pocket [chemical binding]; other site
509173006908	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
509173006909	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
509173006910	ATP binding site [chemical binding]; other site
509173006911	putative Mg++ binding site [ion binding]; other site
509173006912	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
509173006913	nucleotide binding region [chemical binding]; other site
509173006914	ATP-binding site [chemical binding]; other site
509173006915	Helicase associated domain (HA2); Region: HA2; pfam04408
509173006916	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
509173006917	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
509173006918	peroxiredoxin; Region: AhpC; TIGR03137
509173006919	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
509173006920	dimer interface [polypeptide binding]; other site
509173006921	decamer (pentamer of dimers) interface [polypeptide binding]; other site
509173006922	catalytic triad [active]
509173006923	peroxidatic and resolving cysteines [active]
509173006924	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial)
509173006925	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
509173006926	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173006927	S-adenosylmethionine binding site [chemical binding]; other site
509173006928	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
509173006929	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
509173006930	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
509173006931	catalytic residue [active]
509173006932	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
509173006933	catalytic residues [active]
509173006934	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173006935	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173006936	glutathionine S-transferase; Provisional; Region: PRK10542
509173006937	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
509173006938	C-terminal domain interface [polypeptide binding]; other site
509173006939	GSH binding site (G-site) [chemical binding]; other site
509173006940	dimer interface [polypeptide binding]; other site
509173006941	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
509173006942	dimer interface [polypeptide binding]; other site
509173006943	N-terminal domain interface [polypeptide binding]; other site
509173006944	substrate binding pocket (H-site) [chemical binding]; other site
509173006945	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
509173006946	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
509173006947	generic binding surface II; other site
509173006948	generic binding surface I; other site
509173006949	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
509173006950	putative active site [active]
509173006951	putative catalytic site [active]
509173006952	putative Mg binding site IVb [ion binding]; other site
509173006953	putative phosphate binding site [ion binding]; other site
509173006954	putative DNA binding site [nucleotide binding]; other site
509173006955	putative Mg binding site IVa [ion binding]; other site
509173006956	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
509173006957	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
509173006958	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
509173006959	putative C-terminal domain interface [polypeptide binding]; other site
509173006960	putative GSH binding site (G-site) [chemical binding]; other site
509173006961	putative dimer interface [polypeptide binding]; other site
509173006962	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
509173006963	putative N-terminal domain interface [polypeptide binding]; other site
509173006964	putative dimer interface [polypeptide binding]; other site
509173006965	putative substrate binding pocket (H-site) [chemical binding]; other site
509173006966	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
509173006967	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
509173006968	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
509173006969	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
509173006970	ligand binding site [chemical binding]; other site
509173006971	dihydroorotase; Validated; Region: pyrC; PRK09357
509173006972	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
509173006973	active site
509173006974	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
509173006975	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
509173006976	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
509173006977	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
509173006978	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
509173006979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
509173006980	DNA methylase; Region: N6_N4_Mtase; cl17433
509173006981	Competence-damaged protein; Region: CinA; pfam02464
509173006982	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
509173006983	Clp amino terminal domain; Region: Clp_N; pfam02861
509173006984	Clp amino terminal domain; Region: Clp_N; pfam02861
509173006985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173006986	Walker A motif; other site
509173006987	ATP binding site [chemical binding]; other site
509173006988	Walker B motif; other site
509173006989	arginine finger; other site
509173006990	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173006991	Walker A motif; other site
509173006992	ATP binding site [chemical binding]; other site
509173006993	Walker B motif; other site
509173006994	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
509173006995	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
509173006996	Peptidase family M23; Region: Peptidase_M23; pfam01551
509173006997	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173006998	Coenzyme A binding pocket [chemical binding]; other site
509173006999	OsmC-like protein; Region: OsmC; cl00767
509173007000	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
509173007001	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
509173007002	ligand binding site [chemical binding]; other site
509173007003	flexible hinge region; other site
509173007004	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
509173007005	putative switch regulator; other site
509173007006	non-specific DNA interactions [nucleotide binding]; other site
509173007007	DNA binding site [nucleotide binding]
509173007008	sequence specific DNA binding site [nucleotide binding]; other site
509173007009	putative cAMP binding site [chemical binding]; other site
509173007010	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
509173007011	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
509173007012	active site
509173007013	catalytic tetrad [active]
509173007014	Peptidase family M48; Region: Peptidase_M48; pfam01435
509173007015	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
509173007016	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
509173007017	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
509173007018	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
509173007019	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
509173007020	dimer interface [polypeptide binding]; other site
509173007021	motif 1; other site
509173007022	active site
509173007023	motif 2; other site
509173007024	motif 3; other site
509173007025	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
509173007026	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
509173007027	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
509173007028	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
509173007029	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
509173007030	motif 1; other site
509173007031	active site
509173007032	motif 2; other site
509173007033	motif 3; other site
509173007034	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
509173007035	DHHA1 domain; Region: DHHA1; pfam02272
509173007036	aspartate kinase; Reviewed; Region: PRK06635
509173007037	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
509173007038	putative nucleotide binding site [chemical binding]; other site
509173007039	putative catalytic residues [active]
509173007040	putative Mg ion binding site [ion binding]; other site
509173007041	putative aspartate binding site [chemical binding]; other site
509173007042	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
509173007043	putative allosteric regulatory site; other site
509173007044	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
509173007045	carbon storage regulator; Provisional; Region: PRK01712
509173007046	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
509173007047	RNA/DNA hybrid binding site [nucleotide binding]; other site
509173007048	active site
509173007049	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
509173007050	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
509173007051	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
509173007052	active site
509173007053	purine riboside binding site [chemical binding]; other site
509173007054	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
509173007055	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
509173007056	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
509173007057	classical (c) SDRs; Region: SDR_c; cd05233
509173007058	short chain dehydrogenase; Provisional; Region: PRK05650
509173007059	NAD(P) binding site [chemical binding]; other site
509173007060	active site
509173007061	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
509173007062	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
509173007063	Pirin-related protein [General function prediction only]; Region: COG1741
509173007064	Pirin; Region: Pirin; pfam02678
509173007065	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173007066	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173007067	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
509173007068	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
509173007069	classical (c) SDRs; Region: SDR_c; cd05233
509173007070	short chain dehydrogenase; Provisional; Region: PRK05650
509173007071	NAD(P) binding site [chemical binding]; other site
509173007072	active site
509173007073	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
509173007074	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
509173007075	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
509173007076	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
509173007077	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173007078	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173007079	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173007080	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
509173007081	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
509173007082	short chain dehydrogenase; Provisional; Region: PRK06181
509173007083	classical (c) SDRs; Region: SDR_c; cd05233
509173007084	NAD(P) binding site [chemical binding]; other site
509173007085	active site
509173007086	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
509173007087	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
509173007088	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
509173007089	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
509173007090	outer membrane porin, OprD family; Region: OprD; pfam03573
509173007091	benzoate transport; Region: 2A0115; TIGR00895
509173007092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007093	putative substrate translocation pore; other site
509173007094	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007095	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
509173007096	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
509173007097	iron-sulfur cluster [ion binding]; other site
509173007098	[2Fe-2S] cluster binding site [ion binding]; other site
509173007099	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
509173007100	alpha subunit interface [polypeptide binding]; other site
509173007101	active site
509173007102	substrate binding site [chemical binding]; other site
509173007103	Fe binding site [ion binding]; other site
509173007104	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
509173007105	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
509173007106	FMN-binding pocket [chemical binding]; other site
509173007107	flavin binding motif; other site
509173007108	phosphate binding motif [ion binding]; other site
509173007109	beta-alpha-beta structure motif; other site
509173007110	NAD binding pocket [chemical binding]; other site
509173007111	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
509173007112	catalytic loop [active]
509173007113	iron binding site [ion binding]; other site
509173007114	Transcriptional regulators [Transcription]; Region: GntR; COG1802
509173007115	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173007116	DNA-binding site [nucleotide binding]; DNA binding site
509173007117	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
509173007118	MarR family; Region: MarR_2; pfam12802
509173007119	putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551
509173007120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007121	putative substrate translocation pore; other site
509173007122	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
509173007123	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173007124	substrate binding site [chemical binding]; other site
509173007125	oxyanion hole (OAH) forming residues; other site
509173007126	trimer interface [polypeptide binding]; other site
509173007127	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
509173007128	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
509173007129	NAD(P) binding site [chemical binding]; other site
509173007130	catalytic residues [active]
509173007131	feruloyl-CoA synthase; Reviewed; Region: PRK08180
509173007132	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
509173007133	acyl-activating enzyme (AAE) consensus motif; other site
509173007134	putative AMP binding site [chemical binding]; other site
509173007135	putative active site [active]
509173007136	putative CoA binding site [chemical binding]; other site
509173007137	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173007138	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173007139	active site
509173007140	outer membrane porin, OprD family; Region: OprD; pfam03573
509173007141	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
509173007142	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
509173007143	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
509173007144	CoenzymeA binding site [chemical binding]; other site
509173007145	subunit interaction site [polypeptide binding]; other site
509173007146	PHB binding site; other site
509173007147	Tannase and feruloyl esterase; Region: Tannase; pfam07519
509173007148	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
509173007149	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173007150	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173007151	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
509173007152	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
509173007153	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
509173007154	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
509173007155	active site
509173007156	FMN binding site [chemical binding]; other site
509173007157	2,4-decadienoyl-CoA binding site; other site
509173007158	catalytic residue [active]
509173007159	4Fe-4S cluster binding site [ion binding]; other site
509173007160	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
509173007161	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173007162	argininosuccinate synthase; Provisional; Region: PRK13820
509173007163	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
509173007164	ANP binding site [chemical binding]; other site
509173007165	Substrate Binding Site II [chemical binding]; other site
509173007166	Substrate Binding Site I [chemical binding]; other site
509173007167	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
509173007168	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
509173007169	metal binding site [ion binding]; metal-binding site
509173007170	active site
509173007171	I-site; other site
509173007172	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173007173	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173007174	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein; membrane protein
509173007175	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
509173007176	active site
509173007177	substrate binding pocket [chemical binding]; other site
509173007178	dimer interface [polypeptide binding]; other site
509173007179	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
509173007180	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
509173007181	dimer interface [polypeptide binding]; other site
509173007182	catalytic site [active]
509173007183	putative active site [active]
509173007184	putative substrate binding site [chemical binding]; other site
509173007185	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
509173007186	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173007187	N-terminal plug; other site
509173007188	ligand-binding site [chemical binding]; other site
509173007189	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173007190	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173007191	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
509173007192	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
509173007193	Old yellow enzyme (OYE)-related FMN binding domain, group 2.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733
509173007194	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
509173007195	putative active site [active]
509173007196	putative FMN binding site [chemical binding]; other site
509173007197	putative substrate binding site [chemical binding]; other site
509173007198	putative catalytic residue [active]
509173007199	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
509173007200	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
509173007201	Walker A/P-loop; other site
509173007202	ATP binding site [chemical binding]; other site
509173007203	Q-loop/lid; other site
509173007204	ABC transporter signature motif; other site
509173007205	Walker B; other site
509173007206	D-loop; other site
509173007207	H-loop/switch region; other site
509173007208	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
509173007209	Walker A/P-loop; other site
509173007210	ATP binding site [chemical binding]; other site
509173007211	Q-loop/lid; other site
509173007212	ABC transporter signature motif; other site
509173007213	Walker B; other site
509173007214	D-loop; other site
509173007215	H-loop/switch region; other site
509173007216	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
509173007217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173007218	dimer interface [polypeptide binding]; other site
509173007219	conserved gate region; other site
509173007220	putative PBP binding loops; other site
509173007221	ABC-ATPase subunit interface; other site
509173007222	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
509173007223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173007224	dimer interface [polypeptide binding]; other site
509173007225	conserved gate region; other site
509173007226	ABC-ATPase subunit interface; other site
509173007227	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
509173007228	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
509173007229	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
509173007230	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
509173007231	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
509173007232	N-acetyl-D-glucosamine binding site [chemical binding]; other site
509173007233	catalytic residue [active]
509173007234	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173007235	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173007236	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173007237	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
509173007238	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173007239	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173007240	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
509173007241	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173007242	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
509173007243	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173007244	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173007245	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
509173007246	RNA/DNA hybrid binding site [nucleotide binding]; other site
509173007247	active site
509173007248	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
509173007249	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
509173007250	active site
509173007251	catalytic site [active]
509173007252	substrate binding site [chemical binding]; other site
509173007253	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
509173007254	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
509173007255	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
509173007256	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
509173007257	putative NADH binding site [chemical binding]; other site
509173007258	putative active site [active]
509173007259	nudix motif; other site
509173007260	putative metal binding site [ion binding]; other site
509173007261	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
509173007262	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
509173007263	substrate binding pocket [chemical binding]; other site
509173007264	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
509173007265	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
509173007266	BON domain; Region: BON; pfam04972
509173007267	hypothetical protein; Provisional; Region: PRK14674
509173007268	Predicted methyltransferases [General function prediction only]; Region: COG0313
509173007269	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
509173007270	putative SAM binding site [chemical binding]; other site
509173007271	putative homodimer interface [polypeptide binding]; other site
509173007272	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
509173007273	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173007274	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173007275	dimerization interface [polypeptide binding]; other site
509173007276	Lysine efflux permease [General function prediction only]; Region: COG1279
509173007277	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
509173007278	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
509173007279	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
509173007280	DNA binding residues [nucleotide binding]
509173007281	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
509173007282	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
509173007283	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
509173007284	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
509173007285	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
509173007286	proline aminopeptidase P II; Provisional; Region: PRK10879
509173007287	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
509173007288	active site
509173007289	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
509173007290	Cell division protein ZapA; Region: ZapA; pfam05164
509173007291	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
509173007292	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
509173007293	active site
509173007294	Int/Topo IB signature motif; other site
509173007295	DNA binding site [nucleotide binding]
509173007296	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
509173007297	DNA-binding site [nucleotide binding]; DNA binding site
509173007298	RNA-binding motif; other site
509173007299	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
509173007300	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
509173007301	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
509173007302	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
509173007303	Phage-related minor tail protein [Function unknown]; Region: COG5281
509173007304	tape measure domain; Region: tape_meas_nterm; TIGR02675
509173007305	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
509173007306	Peptidase family M23; Region: Peptidase_M23; pfam01551
509173007307	Predicted transcriptional regulator [Transcription]; Region: COG2944
509173007308	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173007309	non-specific DNA binding site [nucleotide binding]; other site
509173007310	salt bridge; other site
509173007311	sequence-specific DNA binding site [nucleotide binding]; other site
509173007312	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
509173007313	LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935
509173007314	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
509173007315	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
509173007316	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
509173007317	Domain of unknown function (DUF4055); Region: DUF4055; pfam13264
509173007318	Terminase-like family; Region: Terminase_6; pfam03237
509173007319	Phage terminase large subunit; Region: Terminase_3; cl12054
509173007320	Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045
509173007321	AAA ATPase domain; Region: AAA_16; pfam13191
509173007322	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
509173007323	putative active site [active]
509173007324	HNH nucleases; Region: HNHc; smart00507
509173007325	active site
509173007326	Evidence 4 : Homologs of previously reported genes of unknown function; fragment of conserved hypothetical protein
509173007327	replicative DNA helicase; Region: DnaB; TIGR00665
509173007328	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
509173007329	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
509173007330	Walker A motif; other site
509173007331	ATP binding site [chemical binding]; other site
509173007332	Walker B motif; other site
509173007333	Helix-turn-helix domain; Region: HTH_36; pfam13730
509173007334	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173007335	non-specific DNA binding site [nucleotide binding]; other site
509173007336	salt bridge; other site
509173007337	Predicted transcriptional regulator [Transcription]; Region: COG2932
509173007338	sequence-specific DNA binding site [nucleotide binding]; other site
509173007339	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
509173007340	Catalytic site [active]
509173007341	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
509173007342	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
509173007343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173007344	S-adenosylmethionine binding site [chemical binding]; other site
509173007345	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
509173007346	AAA domain; Region: AAA_24; pfam13479
509173007347	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
509173007348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173007349	S-adenosylmethionine binding site [chemical binding]; other site
509173007350	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
509173007351	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
509173007352	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
509173007353	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
509173007354	Found in ATP-dependent protease La (LON); Region: LON; smart00464
509173007355	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173007356	Walker A motif; other site
509173007357	ATP binding site [chemical binding]; other site
509173007358	Walker B motif; other site
509173007359	arginine finger; other site
509173007360	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
509173007361	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
509173007362	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
509173007363	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
509173007364	putative active site [active]
509173007365	metal binding site [ion binding]; metal-binding site
509173007366	META domain; Region: META; pfam03724
509173007367	META domain; Region: META; pfam03724
509173007368	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
509173007369	glutamate dehydrogenase; Provisional; Region: PRK09414
509173007370	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
509173007371	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
509173007372	NAD(P) binding site [chemical binding]; other site
509173007373	ferredoxin; Provisional; Region: PRK08764
509173007374	Putative Fe-S cluster; Region: FeS; cl17515
509173007375	4Fe-4S binding domain; Region: Fer4; pfam00037
509173007376	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
509173007377	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
509173007378	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
509173007379	minor groove reading motif; other site
509173007380	helix-hairpin-helix signature motif; other site
509173007381	substrate binding pocket [chemical binding]; other site
509173007382	active site
509173007383	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
509173007384	adenylate kinase; Reviewed; Region: adk; PRK00279
509173007385	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
509173007386	AMP-binding site [chemical binding]; other site
509173007387	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
509173007388	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
509173007389	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
509173007390	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
509173007391	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
509173007392	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173007393	S-adenosylmethionine binding site [chemical binding]; other site
509173007394	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
509173007395	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
509173007396	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
509173007397	UreF; Region: UreF; pfam01730
509173007398	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
509173007399	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
509173007400	dimer interface [polypeptide binding]; other site
509173007401	catalytic residues [active]
509173007402	urease subunit alpha; Reviewed; Region: ureC; PRK13207
509173007403	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
509173007404	subunit interactions [polypeptide binding]; other site
509173007405	active site
509173007406	flap region; other site
509173007407	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
509173007408	gamma-beta subunit interface [polypeptide binding]; other site
509173007409	alpha-beta subunit interface [polypeptide binding]; other site
509173007410	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
509173007411	alpha-gamma subunit interface [polypeptide binding]; other site
509173007412	beta-gamma subunit interface [polypeptide binding]; other site
509173007413	UreD urease accessory protein; Region: UreD; pfam01774
509173007414	Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015
509173007415	NlpE N-terminal domain; Region: NlpE; pfam04170
509173007416	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
509173007417	tetramer interface [polypeptide binding]; other site
509173007418	active site
509173007419	Mg2+/Mn2+ binding site [ion binding]; other site
509173007420	isocitrate lyase; Region: PLN02892
509173007421	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173007422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173007423	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
509173007424	substrate binding pocket [chemical binding]; other site
509173007425	dimerization interface [polypeptide binding]; other site
509173007426	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
509173007427	Domain of unknown function DUF21; Region: DUF21; pfam01595
509173007428	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
509173007429	Transporter associated domain; Region: CorC_HlyC; smart01091
509173007430	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
509173007431	Citrate transporter; Region: CitMHS; pfam03600
509173007432	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
509173007433	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
509173007434	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
509173007435	CysD dimerization site [polypeptide binding]; other site
509173007436	G1 box; other site
509173007437	putative GEF interaction site [polypeptide binding]; other site
509173007438	GTP/Mg2+ binding site [chemical binding]; other site
509173007439	Switch I region; other site
509173007440	G2 box; other site
509173007441	G3 box; other site
509173007442	Switch II region; other site
509173007443	G4 box; other site
509173007444	G5 box; other site
509173007445	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
509173007446	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
509173007447	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
509173007448	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
509173007449	Active Sites [active]
509173007450	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
509173007451	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
509173007452	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
509173007453	dimer interface [polypeptide binding]; other site
509173007454	putative anticodon binding site; other site
509173007455	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
509173007456	motif 1; other site
509173007457	active site
509173007458	motif 2; other site
509173007459	motif 3; other site
509173007460	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
509173007461	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
509173007462	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
509173007463	putative hydrophobic ligand binding site [chemical binding]; other site
509173007464	Rubredoxin [Energy production and conversion]; Region: COG1773
509173007465	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
509173007466	iron binding site [ion binding]; other site
509173007467	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
509173007468	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173007469	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
509173007470	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
509173007471	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
509173007472	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173007473	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
509173007474	dimerization interface [polypeptide binding]; other site
509173007475	Sporulation related domain; Region: SPOR; cl10051
509173007476	polyphosphate kinase; Provisional; Region: PRK05443
509173007477	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
509173007478	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
509173007479	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
509173007480	putative active site [active]
509173007481	catalytic site [active]
509173007482	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
509173007483	putative active site [active]
509173007484	putative domain interface [polypeptide binding]; other site
509173007485	catalytic site [active]
509173007486	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
509173007487	Transglycosylase; Region: Transgly; cl17702
509173007488	Rhomboid family; Region: Rhomboid; pfam01694
509173007489	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
509173007490	FtsX-like permease family; Region: FtsX; pfam02687
509173007491	FtsX-like permease family; Region: FtsX; pfam02687
509173007492	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
509173007493	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
509173007494	Walker A/P-loop; other site
509173007495	ATP binding site [chemical binding]; other site
509173007496	Q-loop/lid; other site
509173007497	ABC transporter signature motif; other site
509173007498	Walker B; other site
509173007499	D-loop; other site
509173007500	H-loop/switch region; other site
509173007501	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
509173007502	active site
509173007503	catalytic triad [active]
509173007504	oxyanion hole [active]
509173007505	switch loop; other site
509173007506	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
509173007507	active site clefts [active]
509173007508	zinc binding site [ion binding]; other site
509173007509	dimer interface [polypeptide binding]; other site
509173007510	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173007511	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
509173007512	nucleophilic elbow; other site
509173007513	catalytic triad; other site
509173007514	outer membrane receptor FepA; Provisional; Region: PRK13524
509173007515	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173007516	N-terminal plug; other site
509173007517	ligand-binding site [chemical binding]; other site
509173007518	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
509173007519	IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341
509173007520	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
509173007521	Rhomboid family; Region: Rhomboid; cl11446
509173007522	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
509173007523	Sulfatase; Region: Sulfatase; pfam00884
509173007524	Uncharacterized conserved protein [Function unknown]; Region: COG1262
509173007525	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
509173007526	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
509173007527	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
509173007528	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
509173007529	catalytic residue [active]
509173007530	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
509173007531	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
509173007532	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
509173007533	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
509173007534	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
509173007535	substrate binding pocket [chemical binding]; other site
509173007536	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
509173007537	B12 binding site [chemical binding]; other site
509173007538	cobalt ligand [ion binding]; other site
509173007539	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
509173007540	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
509173007541	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
509173007542	PYR/PP interface [polypeptide binding]; other site
509173007543	dimer interface [polypeptide binding]; other site
509173007544	TPP binding site [chemical binding]; other site
509173007545	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
509173007546	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
509173007547	TPP-binding site [chemical binding]; other site
509173007548	dimer interface [polypeptide binding]; other site
509173007549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007550	D-galactonate transporter; Region: 2A0114; TIGR00893
509173007551	putative substrate translocation pore; other site
509173007552	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
509173007553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173007554	NAD(P) binding site [chemical binding]; other site
509173007555	active site
509173007556	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
509173007557	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173007558	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
509173007559	dimerization interface [polypeptide binding]; other site
509173007560	substrate binding pocket [chemical binding]; other site
509173007561	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
509173007562	active site
509173007563	catalytic residues [active]
509173007564	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007565	putative substrate translocation pore; other site
509173007566	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173007567	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
509173007568	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173007569	glutaminase; Provisional; Region: PRK00971
509173007570	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
509173007571	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
509173007572	active site
509173007573	catalytic residues [active]
509173007574	metal binding site [ion binding]; metal-binding site
509173007575	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007576	metabolite-proton symporter; Region: 2A0106; TIGR00883
509173007577	putative substrate translocation pore; other site
509173007578	hypothetical protein; Provisional; Region: PRK07064
509173007579	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
509173007580	PYR/PP interface [polypeptide binding]; other site
509173007581	dimer interface [polypeptide binding]; other site
509173007582	TPP binding site [chemical binding]; other site
509173007583	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
509173007584	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
509173007585	TPP-binding site [chemical binding]; other site
509173007586	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
509173007587	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
509173007588	NAD(P) binding site [chemical binding]; other site
509173007589	catalytic residues [active]
509173007590	L-aspartate dehydrogenase; Provisional; Region: PRK13303
509173007591	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
509173007592	Domain of unknown function DUF108; Region: DUF108; pfam01958
509173007593	short chain dehydrogenase; Provisional; Region: PRK07062
509173007594	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
509173007595	putative NAD(P) binding site [chemical binding]; other site
509173007596	putative active site [active]
509173007597	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173007598	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
509173007599	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
509173007600	Cupin domain; Region: Cupin_2; pfam07883
509173007601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007602	D-galactonate transporter; Region: 2A0114; TIGR00893
509173007603	putative substrate translocation pore; other site
509173007604	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
509173007605	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173007606	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
509173007607	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
509173007608	putative active site [active]
509173007609	putative metal binding site [ion binding]; other site
509173007610	short chain dehydrogenase; Provisional; Region: PRK12939
509173007611	classical (c) SDRs; Region: SDR_c; cd05233
509173007612	NAD(P) binding site [chemical binding]; other site
509173007613	active site
509173007614	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
509173007615	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
509173007616	[2Fe-2S] cluster binding site [ion binding]; other site
509173007617	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
509173007618	hydrophobic ligand binding site; other site
509173007619	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
509173007620	[2Fe-2S] cluster binding site [ion binding]; other site
509173007621	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
509173007622	Transcriptional regulator [Transcription]; Region: IclR; COG1414
509173007623	Bacterial transcriptional regulator; Region: IclR; pfam01614
509173007624	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
509173007625	enoyl-CoA hydratase; Provisional; Region: PRK06563
509173007626	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173007627	substrate binding site [chemical binding]; other site
509173007628	oxyanion hole (OAH) forming residues; other site
509173007629	trimer interface [polypeptide binding]; other site
509173007630	PgaD-like protein; Region: PgaD; pfam13994
509173007631	N-glycosyltransferase; Provisional; Region: PRK11204
509173007632	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
509173007633	DXD motif; other site
509173007634	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
509173007635	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
509173007636	putative active site [active]
509173007637	putative metal binding site [ion binding]; other site
509173007638	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
509173007639	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
509173007640	YaeQ protein; Region: YaeQ; pfam07152
509173007641	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
509173007642	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
509173007643	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
509173007644	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
509173007645	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
509173007646	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
509173007647	choline transport protein BetT; Provisional; Region: PRK09928
509173007648	BCCT family transporter; Region: BCCT; pfam02028
509173007649	transcriptional regulator BetI; Validated; Region: PRK00767
509173007650	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173007651	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
509173007652	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
509173007653	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
509173007654	tetrameric interface [polypeptide binding]; other site
509173007655	NAD binding site [chemical binding]; other site
509173007656	catalytic residues [active]
509173007657	choline dehydrogenase; Validated; Region: PRK02106
509173007658	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
509173007659	malate:quinone oxidoreductase; Validated; Region: PRK05257
509173007660	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
509173007661	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
509173007662	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
509173007663	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
509173007664	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173007665	PGAP1-like protein; Region: PGAP1; pfam07819
509173007666	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
509173007667	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173007668	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173007669	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
509173007670	putative dimerization interface [polypeptide binding]; other site
509173007671	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
509173007672	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
509173007673	inhibitor site; inhibition site
509173007674	active site
509173007675	dimer interface [polypeptide binding]; other site
509173007676	catalytic residue [active]
509173007677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007678	benzoate transport; Region: 2A0115; TIGR00895
509173007679	putative substrate translocation pore; other site
509173007680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007681	outer membrane porin, OprD family; Region: OprD; pfam03573
509173007682	outer membrane porin, OprD family; Region: OprD; pfam03573
509173007683	Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; Region: DHR2_DOCK; cl06123
509173007684	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
509173007685	active site
509173007686	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
509173007687	Ligand Binding Site [chemical binding]; other site
509173007688	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
509173007689	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
509173007690	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
509173007691	Nucleoid-associated protein [General function prediction only]; Region: COG3081
509173007692	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
509173007693	Domain of unknown function (DUF927); Region: DUF927; pfam06048
509173007694	Prophage antirepressor [Transcription]; Region: COG3617
509173007695	BRO family, N-terminal domain; Region: Bro-N; smart01040
509173007696	Helix-turn-helix domain; Region: HTH_39; pfam14090
509173007697	integrase; Provisional; Region: PRK09692
509173007698	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
509173007699	active site
509173007700	Int/Topo IB signature motif; other site
509173007701	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
509173007702	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
509173007703	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007704	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173007705	putative substrate translocation pore; other site
509173007706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173007707	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
509173007708	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173007709	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173007710	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
509173007711	CoenzymeA binding site [chemical binding]; other site
509173007712	subunit interaction site [polypeptide binding]; other site
509173007713	PHB binding site; other site
509173007714	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
509173007715	dimer interface [polypeptide binding]; other site
509173007716	allosteric magnesium binding site [ion binding]; other site
509173007717	active site
509173007718	aspartate-rich active site metal binding site; other site
509173007719	Schiff base residues; other site
509173007720	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
509173007721	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173007722	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
509173007723	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173007724	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
509173007725	NAD(P) binding site [chemical binding]; other site
509173007726	active site
509173007727	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
509173007728	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
509173007729	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
509173007730	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
509173007731	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
509173007732	active site
509173007733	metal binding site [ion binding]; metal-binding site
509173007734	DNA binding site [nucleotide binding]
509173007735	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
509173007736	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173007737	Walker A/P-loop; other site
509173007738	ATP binding site [chemical binding]; other site
509173007739	Q-loop/lid; other site
509173007740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173007741	ABC transporter signature motif; other site
509173007742	Walker B; other site
509173007743	D-loop; other site
509173007744	H-loop/switch region; other site
509173007745	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
509173007746	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
509173007747	catalytic residue [active]
509173007748	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
509173007749	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
509173007750	Walker A motif; other site
509173007751	ATP binding site [chemical binding]; other site
509173007752	Walker B motif; other site
509173007753	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
509173007754	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
509173007755	Walker A motif; other site
509173007756	ATP binding site [chemical binding]; other site
509173007757	Walker B motif; other site
509173007758	ferric uptake regulator; Provisional; Region: fur; PRK09462
509173007759	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
509173007760	metal binding site 2 [ion binding]; metal-binding site
509173007761	putative DNA binding helix; other site
509173007762	metal binding site 1 [ion binding]; metal-binding site
509173007763	dimer interface [polypeptide binding]; other site
509173007764	structural Zn2+ binding site [ion binding]; other site
509173007765	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
509173007766	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
509173007767	hypothetical protein; Validated; Region: PRK01777
509173007768	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
509173007769	Hemerythrin; Region: Hemerythrin; cd12107
509173007770	Fe binding site [ion binding]; other site
509173007771	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
509173007772	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
509173007773	putative active site [active]
509173007774	putative dimer interface [polypeptide binding]; other site
509173007775	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
509173007776	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
509173007777	feedback inhibition sensing region; other site
509173007778	homohexameric interface [polypeptide binding]; other site
509173007779	nucleotide binding site [chemical binding]; other site
509173007780	N-acetyl-L-glutamate binding site [chemical binding]; other site
509173007781	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
509173007782	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
509173007783	active site
509173007784	substrate binding site [chemical binding]; other site
509173007785	metal binding site [ion binding]; metal-binding site
509173007786	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
509173007787	trimer interface [polypeptide binding]; other site
509173007788	active site
509173007789	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
509173007790	Part of AAA domain; Region: AAA_19; pfam13245
509173007791	Family description; Region: UvrD_C_2; pfam13538
509173007792	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
509173007793	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
509173007794	ligand binding site [chemical binding]; other site
509173007795	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
509173007796	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
509173007797	putative acyl-acceptor binding pocket; other site
509173007798	Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850
509173007799	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
509173007800	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
509173007801	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
509173007802	Switch I; other site
509173007803	Switch II; other site
509173007804	Septum formation topological specificity factor MinE; Region: MinE; pfam03776
509173007805	threonine efflux system; Provisional; Region: PRK10229
509173007806	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
509173007807	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
509173007808	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
509173007809	thioredoxin reductase; Provisional; Region: PRK10262
509173007810	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173007811	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173007812	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
509173007813	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
509173007814	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
509173007815	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
509173007816	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
509173007817	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173007818	Coenzyme A binding pocket [chemical binding]; other site
509173007819	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
509173007820	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
509173007821	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
509173007822	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
509173007823	elongation factor Tu; Reviewed; Region: PRK00049
509173007824	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
509173007825	G1 box; other site
509173007826	GEF interaction site [polypeptide binding]; other site
509173007827	GTP/Mg2+ binding site [chemical binding]; other site
509173007828	Switch I region; other site
509173007829	G2 box; other site
509173007830	G3 box; other site
509173007831	Switch II region; other site
509173007832	G4 box; other site
509173007833	G5 box; other site
509173007834	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
509173007835	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
509173007836	Antibiotic Binding Site [chemical binding]; other site
509173007837	elongation factor G; Reviewed; Region: PRK00007
509173007838	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
509173007839	G1 box; other site
509173007840	putative GEF interaction site [polypeptide binding]; other site
509173007841	GTP/Mg2+ binding site [chemical binding]; other site
509173007842	Switch I region; other site
509173007843	G2 box; other site
509173007844	G3 box; other site
509173007845	Switch II region; other site
509173007846	G4 box; other site
509173007847	G5 box; other site
509173007848	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
509173007849	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
509173007850	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
509173007851	30S ribosomal protein S7; Validated; Region: PRK05302
509173007852	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
509173007853	S17 interaction site [polypeptide binding]; other site
509173007854	S8 interaction site; other site
509173007855	16S rRNA interaction site [nucleotide binding]; other site
509173007856	streptomycin interaction site [chemical binding]; other site
509173007857	23S rRNA interaction site [nucleotide binding]; other site
509173007858	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
509173007859	EcsC protein family; Region: EcsC; pfam12787
509173007860	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
509173007861	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
509173007862	dimer interface [polypeptide binding]; other site
509173007863	active site
509173007864	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
509173007865	Pirin; Region: Pirin; pfam02678
509173007866	Pirin-related protein [General function prediction only]; Region: COG1741
509173007867	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
509173007868	NAD synthetase; Provisional; Region: PRK13981
509173007869	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
509173007870	multimer interface [polypeptide binding]; other site
509173007871	active site
509173007872	catalytic triad [active]
509173007873	protein interface 1 [polypeptide binding]; other site
509173007874	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
509173007875	homodimer interface [polypeptide binding]; other site
509173007876	NAD binding pocket [chemical binding]; other site
509173007877	ATP binding pocket [chemical binding]; other site
509173007878	Mg binding site [ion binding]; other site
509173007879	active-site loop [active]
509173007880	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
509173007881	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
509173007882	FMN-binding pocket [chemical binding]; other site
509173007883	flavin binding motif; other site
509173007884	phosphate binding motif [ion binding]; other site
509173007885	beta-alpha-beta structure motif; other site
509173007886	NAD binding pocket [chemical binding]; other site
509173007887	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
509173007888	catalytic loop [active]
509173007889	iron binding site [ion binding]; other site
509173007890	succinic semialdehyde dehydrogenase; Region: PLN02278
509173007891	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
509173007892	tetramerization interface [polypeptide binding]; other site
509173007893	NAD(P) binding site [chemical binding]; other site
509173007894	catalytic residues [active]
509173007895	Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of  dioxygenase alpha subunit (part 2)
509173007896	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173007897	Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of  dioxygenase alpha subunit (part 1)
509173007898	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
509173007899	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
509173007900	substrate binding pocket [chemical binding]; other site
509173007901	putative transporter; Provisional; Region: PRK09950
509173007902	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
509173007903	tartrate dehydrogenase; Region: TTC; TIGR02089
509173007904	transcriptional activator TtdR; Provisional; Region: PRK09801
509173007905	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173007906	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
509173007907	putative effector binding pocket; other site
509173007908	putative dimerization interface [polypeptide binding]; other site
509173007909	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
509173007910	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
509173007911	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
509173007912	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
509173007913	active site
509173007914	(T/H)XGH motif; other site
509173007915	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
509173007916	SmpB-tmRNA interface; other site
509173007917	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
509173007918	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
509173007919	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
509173007920	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
509173007921	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
509173007922	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
509173007923	RNA binding surface [nucleotide binding]; other site
509173007924	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
509173007925	active site
509173007926	Outer membrane lipoprotein; Region: YfiO; pfam13525
509173007927	DNA primase, catalytic core; Region: dnaG; TIGR01391
509173007928	CHC2 zinc finger; Region: zf-CHC2; pfam01807
509173007929	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
509173007930	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
509173007931	active site
509173007932	metal binding site [ion binding]; metal-binding site
509173007933	interdomain interaction site; other site
509173007934	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
509173007935	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
509173007936	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
509173007937	tRNA; other site
509173007938	putative tRNA binding site [nucleotide binding]; other site
509173007939	putative NADP binding site [chemical binding]; other site
509173007940	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
509173007941	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
509173007942	binding surface
509173007943	TPR motif; other site
509173007944	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
509173007945	binding surface
509173007946	TPR motif; other site
509173007947	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
509173007948	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
509173007949	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
509173007950	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
509173007951	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
509173007952	active site
509173007953	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
509173007954	5S rRNA interface [nucleotide binding]; other site
509173007955	CTC domain interface [polypeptide binding]; other site
509173007956	L16 interface [polypeptide binding]; other site
509173007957	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
509173007958	putative active site [active]
509173007959	catalytic residue [active]
509173007960	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
509173007961	tetramerization interface [polypeptide binding]; other site
509173007962	active site
509173007963	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
509173007964	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
509173007965	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
509173007966	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
509173007967	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
509173007968	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
509173007969	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173007970	motif II; other site
509173007971	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
509173007972	dimer interface [polypeptide binding]; other site
509173007973	substrate binding site [chemical binding]; other site
509173007974	ATP binding site [chemical binding]; other site
509173007975	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
509173007976	BON domain; Region: BON; pfam04972
509173007977	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173007978	acyl carrier protein; Provisional; Region: acpP; PRK00982
509173007979	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
509173007980	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
509173007981	NAD(P) binding site [chemical binding]; other site
509173007982	homotetramer interface [polypeptide binding]; other site
509173007983	homodimer interface [polypeptide binding]; other site
509173007984	active site
509173007985	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
509173007986	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
509173007987	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
509173007988	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
509173007989	Protein of unknown function, DUF462; Region: DUF462; pfam04315
509173007990	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
509173007991	ScpA/B protein; Region: ScpA_ScpB; cl00598
509173007992	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
509173007993	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
509173007994	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
509173007995	RNA binding surface [nucleotide binding]; other site
509173007996	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
509173007997	probable active site [active]
509173007998	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
509173007999	AAA domain; Region: AAA_26; pfam13500
509173008000	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
509173008001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173008002	S-adenosylmethionine binding site [chemical binding]; other site
509173008003	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
509173008004	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
509173008005	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
509173008006	catalytic residue [active]
509173008007	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
509173008008	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173
509173008009	inhibitor-cofactor binding pocket; inhibition site
509173008010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173008011	catalytic residue [active]
509173008012	carboxylesterase BioH; Provisional; Region: PRK10349
509173008013	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
509173008014	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173008015	active site
509173008016	motif I; other site
509173008017	motif II; other site
509173008018	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
509173008019	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
509173008020	active site
509173008021	homotetramer interface [polypeptide binding]; other site
509173008022	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173008023	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173008024	putative substrate translocation pore; other site
509173008025	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
509173008026	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
509173008027	heme binding site [chemical binding]; other site
509173008028	ferroxidase pore; other site
509173008029	ferroxidase diiron center [ion binding]; other site
509173008030	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
509173008031	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
509173008032	nucleotide binding pocket [chemical binding]; other site
509173008033	K-X-D-G motif; other site
509173008034	catalytic site [active]
509173008035	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
509173008036	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
509173008037	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
509173008038	Dimer interface [polypeptide binding]; other site
509173008039	BRCT sequence motif; other site
509173008040	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
509173008041	FtsZ protein binding site [polypeptide binding]; other site
509173008042	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
509173008043	AAA domain; Region: AAA_23; pfam13476
509173008044	Walker A/P-loop; other site
509173008045	ATP binding site [chemical binding]; other site
509173008046	Q-loop/lid; other site
509173008047	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
509173008048	ABC transporter signature motif; other site
509173008049	Walker B; other site
509173008050	D-loop; other site
509173008051	H-loop/switch region; other site
509173008052	Transcriptional regulators [Transcription]; Region: GntR; COG1802
509173008053	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173008054	DNA-binding site [nucleotide binding]; DNA binding site
509173008055	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
509173008056	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
509173008057	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
509173008058	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
509173008059	pantothenate kinase; Reviewed; Region: PRK13322
509173008060	signal recognition particle protein; Provisional; Region: PRK10867
509173008061	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
509173008062	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
509173008063	GTP binding site [chemical binding]; other site
509173008064	Signal peptide binding domain; Region: SRP_SPB; pfam02978
509173008065	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
509173008066	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
509173008067	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
509173008068	FMN binding site [chemical binding]; other site
509173008069	active site
509173008070	catalytic residues [active]
509173008071	substrate binding site [chemical binding]; other site
509173008072	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
509173008073	trimer interface [polypeptide binding]; other site
509173008074	active site
509173008075	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173008076	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
509173008077	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
509173008078	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
509173008079	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
509173008080	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
509173008081	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
509173008082	active site
509173008083	HIGH motif; other site
509173008084	KMSKS motif; other site
509173008085	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
509173008086	tRNA binding surface [nucleotide binding]; other site
509173008087	anticodon binding site; other site
509173008088	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
509173008089	dimer interface [polypeptide binding]; other site
509173008090	putative tRNA-binding site [nucleotide binding]; other site
509173008091	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173008092	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173008093	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173008094	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173008095	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173008096	putative substrate translocation pore; other site
509173008097	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
509173008098	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173008099	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173008100	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
509173008101	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
509173008102	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
509173008103	catalytic residue [active]
509173008104	HI0933-like protein; Region: HI0933_like; pfam03486
509173008105	Conserved TM helix; Region: TM_helix; pfam05552
509173008106	Conserved TM helix; Region: TM_helix; pfam05552
509173008107	Conserved TM helix; Region: TM_helix; pfam05552
509173008108	Conserved TM helix; Region: TM_helix; pfam05552
509173008109	ferredoxin-NADP reductase; Provisional; Region: PRK10926
509173008110	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
509173008111	FAD binding pocket [chemical binding]; other site
509173008112	FAD binding motif [chemical binding]; other site
509173008113	phosphate binding motif [ion binding]; other site
509173008114	beta-alpha-beta structure motif; other site
509173008115	NAD binding pocket [chemical binding]; other site
509173008116	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
509173008117	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173008118	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
509173008119	putative dimerization interface [polypeptide binding]; other site
509173008120	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
509173008121	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
509173008122	DNA-binding site [nucleotide binding]; DNA binding site
509173008123	RNA-binding motif; other site
509173008124	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
509173008125	active site
509173008126	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
509173008127	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
509173008128	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
509173008129	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
509173008130	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
509173008131	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
509173008132	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
509173008133	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
509173008134	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
509173008135	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
509173008136	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
509173008137	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
509173008138	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
509173008139	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
509173008140	NADH dehydrogenase subunit G; Validated; Region: PRK08166
509173008141	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
509173008142	catalytic loop [active]
509173008143	iron binding site [ion binding]; other site
509173008144	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
509173008145	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
509173008146	[4Fe-4S] binding site [ion binding]; other site
509173008147	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
509173008148	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
509173008149	SLBB domain; Region: SLBB; pfam10531
509173008150	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
509173008151	NADH dehydrogenase subunit E; Validated; Region: PRK07539
509173008152	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
509173008153	putative dimer interface [polypeptide binding]; other site
509173008154	[2Fe-2S] cluster binding site [ion binding]; other site
509173008155	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
509173008156	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
509173008157	NADH dehydrogenase subunit D; Validated; Region: PRK06075
509173008158	NADH dehydrogenase subunit B; Validated; Region: PRK06411
509173008159	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
509173008160	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
509173008161	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
509173008162	metal binding site [ion binding]; metal-binding site
509173008163	active site
509173008164	I-site; other site
509173008165	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
509173008166	dimerization interface [polypeptide binding]; other site
509173008167	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173008168	dimer interface [polypeptide binding]; other site
509173008169	phosphorylation site [posttranslational modification]
509173008170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173008171	ATP binding site [chemical binding]; other site
509173008172	Mg2+ binding site [ion binding]; other site
509173008173	G-X-G motif; other site
509173008174	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
509173008175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173008176	active site
509173008177	phosphorylation site [posttranslational modification]
509173008178	intermolecular recognition site; other site
509173008179	dimerization interface [polypeptide binding]; other site
509173008180	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173008181	DNA binding site [nucleotide binding]
509173008182	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
509173008183	ATP cone domain; Region: ATP-cone; pfam03477
509173008184	Class I ribonucleotide reductase; Region: RNR_I; cd01679
509173008185	active site
509173008186	dimer interface [polypeptide binding]; other site
509173008187	catalytic residues [active]
509173008188	effector binding site; other site
509173008189	R2 peptide binding site; other site
509173008190	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
509173008191	dimer interface [polypeptide binding]; other site
509173008192	putative radical transfer pathway; other site
509173008193	diiron center [ion binding]; other site
509173008194	tyrosyl radical; other site
509173008195	hypothetical protein; Provisional; Region: PRK10281
509173008196	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173008197	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173008198	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173008199	dimerization interface [polypeptide binding]; other site
509173008200	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173008201	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173008202	Flavin Reductases; Region: FlaRed; cl00801
509173008203	methionine synthase; Provisional; Region: PRK01207
509173008204	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
509173008205	substrate binding site [chemical binding]; other site
509173008206	THF binding site; other site
509173008207	zinc-binding site [ion binding]; other site
509173008208	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
509173008209	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
509173008210	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173008211	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173008212	dimerization interface [polypeptide binding]; other site
509173008213	LysE type translocator; Region: LysE; cl00565
509173008214	Fatty acid desaturase; Region: FA_desaturase; pfam00487
509173008215	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173008216	SurA N-terminal domain; Region: SurA_N; pfam09312
509173008217	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173008218	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173008219	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
509173008220	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
509173008221	metal binding site [ion binding]; metal-binding site
509173008222	putative dimer interface [polypeptide binding]; other site
509173008223	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
509173008224	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173008225	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173008226	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
509173008227	putative dimerization interface [polypeptide binding]; other site
509173008228	citrate-proton symporter; Provisional; Region: PRK15075
509173008229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173008230	putative substrate translocation pore; other site
509173008231	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
509173008232	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
509173008233	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
509173008234	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173008235	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
509173008236	putative dimerization interface [polypeptide binding]; other site
509173008237	tricarballylate dehydrogenase; Validated; Region: PRK08274
509173008238	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
509173008239	tricarballylate utilization protein B; Provisional; Region: PRK15033
509173008240	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
509173008241	nitrobindin heme-binding domain; Region: nitrobindin; cl10502
509173008242	CoA-transferase family III; Region: CoA_transf_3; pfam02515
509173008243	benzoate transport; Region: 2A0115; TIGR00895
509173008244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173008245	putative substrate translocation pore; other site
509173008246	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
509173008247	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173008248	FAD binding site [chemical binding]; other site
509173008249	substrate binding pocket [chemical binding]; other site
509173008250	catalytic base [active]
509173008251	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
509173008252	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173008253	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173008254	dimerization interface [polypeptide binding]; other site
509173008255	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
509173008256	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
509173008257	putative NAD(P) binding site [chemical binding]; other site
509173008258	catalytic Zn binding site [ion binding]; other site
509173008259	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
509173008260	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
509173008261	active site
509173008262	purine riboside binding site [chemical binding]; other site
509173008263	quinolinate synthetase; Provisional; Region: PRK09375
509173008264	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
509173008265	heterotetramer interface [polypeptide binding]; other site
509173008266	active site pocket [active]
509173008267	cleavage site
509173008268	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
509173008269	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
509173008270	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
509173008271	DNA binding site [nucleotide binding]
509173008272	active site
509173008273	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
509173008274	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
509173008275	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
509173008276	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
509173008277	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
509173008278	Multicopper oxidase; Region: Cu-oxidase; pfam00394
509173008279	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
509173008280	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173008281	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
509173008282	active site
509173008283	motif I; other site
509173008284	motif II; other site
509173008285	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173008286	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
509173008287	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
509173008288	substrate binding site [chemical binding]; other site
509173008289	hexamer interface [polypeptide binding]; other site
509173008290	metal binding site [ion binding]; metal-binding site
509173008291	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
509173008292	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
509173008293	S-formylglutathione hydrolase; Region: PLN02442
509173008294	Peptidase C13 family; Region: Peptidase_C13; pfam01650
509173008295	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
509173008296	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
509173008297	Glycoprotease family; Region: Peptidase_M22; pfam00814
509173008298	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
509173008299	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
509173008300	trimer interface [polypeptide binding]; other site
509173008301	putative metal binding site [ion binding]; other site
509173008302	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
509173008303	putative active site [active]
509173008304	putative CoA binding site [chemical binding]; other site
509173008305	nudix motif; other site
509173008306	metal binding site [ion binding]; metal-binding site
509173008307	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
509173008308	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
509173008309	nudix motif; other site
509173008310	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
509173008311	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907
509173008312	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
509173008313	putative active site [active]
509173008314	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
509173008315	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
509173008316	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
509173008317	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
509173008318	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173008319	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173008320	homodimer interface [polypeptide binding]; other site
509173008321	catalytic residue [active]
509173008322	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
509173008323	histidinol dehydrogenase; Region: hisD; TIGR00069
509173008324	NAD binding site [chemical binding]; other site
509173008325	dimerization interface [polypeptide binding]; other site
509173008326	product binding site; other site
509173008327	substrate binding site [chemical binding]; other site
509173008328	zinc binding site [ion binding]; other site
509173008329	catalytic residues [active]
509173008330	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
509173008331	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
509173008332	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
509173008333	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
509173008334	hinge; other site
509173008335	active site
509173008336	BolA-like protein; Region: BolA; cl00386
509173008337	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
509173008338	30S subunit binding site; other site
509173008339	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
509173008340	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
509173008341	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
509173008342	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
509173008343	VacJ like lipoprotein; Region: VacJ; cl01073
509173008344	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
509173008345	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
509173008346	anti sigma factor interaction site; other site
509173008347	regulatory phosphorylation site [posttranslational modification]; other site
509173008348	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
509173008349	nitrilase; Region: PLN02798
509173008350	putative active site [active]
509173008351	catalytic triad [active]
509173008352	dimer interface [polypeptide binding]; other site
509173008353	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
509173008354	MarR family; Region: MarR; pfam01047
509173008355	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
509173008356	type II secretion system protein E; Region: type_II_gspE; TIGR02533
509173008357	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
509173008358	Walker A motif; other site
509173008359	ATP binding site [chemical binding]; other site
509173008360	Walker B motif; other site
509173008361	Protein of unknown function (DUF432); Region: DUF432; cl01027
509173008362	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
509173008363	Mechanosensitive ion channel; Region: MS_channel; pfam00924
509173008364	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
509173008365	DNA polymerase I; Provisional; Region: PRK05755
509173008366	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
509173008367	active site
509173008368	metal binding site 1 [ion binding]; metal-binding site
509173008369	putative 5' ssDNA interaction site; other site
509173008370	metal binding site 3; metal-binding site
509173008371	metal binding site 2 [ion binding]; metal-binding site
509173008372	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
509173008373	putative DNA binding site [nucleotide binding]; other site
509173008374	putative metal binding site [ion binding]; other site
509173008375	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
509173008376	active site
509173008377	catalytic site [active]
509173008378	substrate binding site [chemical binding]; other site
509173008379	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
509173008380	active site
509173008381	DNA binding site [nucleotide binding]
509173008382	catalytic site [active]
509173008383	YGGT family; Region: YGGT; pfam02325
509173008384	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
509173008385	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
509173008386	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
509173008387	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
509173008388	Ligand Binding Site [chemical binding]; other site
509173008389	TilS substrate binding domain; Region: TilS; pfam09179
509173008390	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
509173008391	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
509173008392	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
509173008393	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
509173008394	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
509173008395	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
509173008396	catalytic residues [active]
509173008397	transcription termination factor Rho; Provisional; Region: rho; PRK09376
509173008398	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
509173008399	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
509173008400	RNA binding site [nucleotide binding]; other site
509173008401	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
509173008402	multimer interface [polypeptide binding]; other site
509173008403	Walker A motif; other site
509173008404	ATP binding site [chemical binding]; other site
509173008405	Walker B motif; other site
509173008406	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
509173008407	IHF dimer interface [polypeptide binding]; other site
509173008408	IHF - DNA interface [nucleotide binding]; other site
509173008409	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
509173008410	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
509173008411	putative tRNA-binding site [nucleotide binding]; other site
509173008412	B3/4 domain; Region: B3_4; pfam03483
509173008413	tRNA synthetase B5 domain; Region: B5; smart00874
509173008414	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
509173008415	dimer interface [polypeptide binding]; other site
509173008416	motif 1; other site
509173008417	motif 3; other site
509173008418	motif 2; other site
509173008419	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
509173008420	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
509173008421	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
509173008422	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
509173008423	dimer interface [polypeptide binding]; other site
509173008424	motif 1; other site
509173008425	active site
509173008426	motif 2; other site
509173008427	motif 3; other site
509173008428	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
509173008429	23S rRNA binding site [nucleotide binding]; other site
509173008430	L21 binding site [polypeptide binding]; other site
509173008431	L13 binding site [polypeptide binding]; other site
509173008432	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
509173008433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173008434	putative substrate translocation pore; other site
509173008435	H+ Antiporter protein; Region: 2A0121; TIGR00900
509173008436	Predicted membrane protein [Function unknown]; Region: COG1238
509173008437	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
509173008438	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
509173008439	C-terminal domain interface [polypeptide binding]; other site
509173008440	GSH binding site (G-site) [chemical binding]; other site
509173008441	dimer interface [polypeptide binding]; other site
509173008442	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
509173008443	N-terminal domain interface [polypeptide binding]; other site
509173008444	putative dimer interface [polypeptide binding]; other site
509173008445	active site
509173008446	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
509173008447	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
509173008448	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
509173008449	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
509173008450	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
509173008451	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
509173008452	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
509173008453	active site
509173008454	dimer interface [polypeptide binding]; other site
509173008455	motif 1; other site
509173008456	motif 2; other site
509173008457	motif 3; other site
509173008458	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
509173008459	anticodon binding site; other site
509173008460	acyl-CoA synthetase; Validated; Region: PRK08162
509173008461	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
509173008462	acyl-activating enzyme (AAE) consensus motif; other site
509173008463	putative active site [active]
509173008464	AMP binding site [chemical binding]; other site
509173008465	putative CoA binding site [chemical binding]; other site
509173008466	hypothetical protein; Provisional; Region: PRK05255
509173008467	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
509173008468	dimerization domain swap beta strand [polypeptide binding]; other site
509173008469	regulatory protein interface [polypeptide binding]; other site
509173008470	active site
509173008471	regulatory phosphorylation site [posttranslational modification]; other site
509173008472	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
509173008473	pantoate--beta-alanine ligase; Region: panC; TIGR00018
509173008474	Pantoate-beta-alanine ligase; Region: PanC; cd00560
509173008475	active site
509173008476	ATP-binding site [chemical binding]; other site
509173008477	pantoate-binding site; other site
509173008478	HXXH motif; other site
509173008479	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
509173008480	oligomerization interface [polypeptide binding]; other site
509173008481	active site
509173008482	metal binding site [ion binding]; metal-binding site
509173008483	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
509173008484	catalytic center binding site [active]
509173008485	ATP binding site [chemical binding]; other site
509173008486	poly(A) polymerase; Region: pcnB; TIGR01942
509173008487	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
509173008488	active site
509173008489	NTP binding site [chemical binding]; other site
509173008490	metal binding triad [ion binding]; metal-binding site
509173008491	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
509173008492	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
509173008493	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
509173008494	Helix-hairpin-helix motif; Region: HHH; pfam00633
509173008495	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
509173008496	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
509173008497	homodimer interface [polypeptide binding]; other site
509173008498	metal binding site [ion binding]; metal-binding site
509173008499	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
509173008500	homodimer interface [polypeptide binding]; other site
509173008501	active site
509173008502	putative chemical substrate binding site [chemical binding]; other site
509173008503	metal binding site [ion binding]; metal-binding site
509173008504	short chain dehydrogenase; Provisional; Region: PRK08267
509173008505	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173008506	NAD(P) binding site [chemical binding]; other site
509173008507	active site
509173008508	HD domain; Region: HD_4; pfam13328
509173008509	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
509173008510	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
509173008511	synthetase active site [active]
509173008512	NTP binding site [chemical binding]; other site
509173008513	metal binding site [ion binding]; metal-binding site
509173008514	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
509173008515	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
509173008516	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
509173008517	TRAM domain; Region: TRAM; pfam01938
509173008518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
509173008519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173008520	S-adenosylmethionine binding site [chemical binding]; other site
509173008521	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
509173008522	active site
509173008523	catalytic site [active]
509173008524	substrate binding site [chemical binding]; other site
509173008525	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
509173008526	cysteine synthase B; Region: cysM; TIGR01138
509173008527	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
509173008528	dimer interface [polypeptide binding]; other site
509173008529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173008530	catalytic residue [active]
509173008531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173008532	dimer interface [polypeptide binding]; other site
509173008533	phosphorylation site [posttranslational modification]
509173008534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173008535	ATP binding site [chemical binding]; other site
509173008536	Mg2+ binding site [ion binding]; other site
509173008537	G-X-G motif; other site
509173008538	Response regulator receiver domain; Region: Response_reg; pfam00072
509173008539	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173008540	active site
509173008541	phosphorylation site [posttranslational modification]
509173008542	intermolecular recognition site; other site
509173008543	dimerization interface [polypeptide binding]; other site
509173008544	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
509173008545	enoyl-CoA hydratase; Provisional; Region: PRK07509
509173008546	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173008547	substrate binding site [chemical binding]; other site
509173008548	oxyanion hole (OAH) forming residues; other site
509173008549	trimer interface [polypeptide binding]; other site
509173008550	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
509173008551	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
509173008552	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
509173008553	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
509173008554	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
509173008555	acetoacetyl-CoA reductase; Provisional; Region: PRK12935
509173008556	putative NAD(P) binding site [chemical binding]; other site
509173008557	active site
509173008558	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
509173008559	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
509173008560	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
509173008561	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
509173008562	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
509173008563	ligand binding site [chemical binding]; other site
509173008564	homodimer interface [polypeptide binding]; other site
509173008565	NAD(P) binding site [chemical binding]; other site
509173008566	trimer interface B [polypeptide binding]; other site
509173008567	trimer interface A [polypeptide binding]; other site
509173008568	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
509173008569	EamA-like transporter family; Region: EamA; pfam00892
509173008570	EamA-like transporter family; Region: EamA; pfam00892
509173008571	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
509173008572	homotrimer interaction site [polypeptide binding]; other site
509173008573	putative active site [active]
509173008574	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
509173008575	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173008576	putative substrate translocation pore; other site
509173008577	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
509173008578	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
509173008579	non-specific DNA binding site [nucleotide binding]; other site
509173008580	salt bridge; other site
509173008581	sequence-specific DNA binding site [nucleotide binding]; other site
509173008582	Domain of unknown function (DUF955); Region: DUF955; cl01076
509173008583	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
509173008584	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
509173008585	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
509173008586	Multicopper oxidase; Region: Cu-oxidase; pfam00394
509173008587	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
509173008588	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
509173008589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173008590	active site
509173008591	phosphorylation site [posttranslational modification]
509173008592	intermolecular recognition site; other site
509173008593	dimerization interface [polypeptide binding]; other site
509173008594	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
509173008595	DNA binding site [nucleotide binding]
509173008596	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
509173008597	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
509173008598	dimerization interface [polypeptide binding]; other site
509173008599	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173008600	dimer interface [polypeptide binding]; other site
509173008601	phosphorylation site [posttranslational modification]
509173008602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173008603	ATP binding site [chemical binding]; other site
509173008604	Mg2+ binding site [ion binding]; other site
509173008605	G-X-G motif; other site
509173008606	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
509173008607	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
509173008608	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
509173008609	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173008610	motif II; other site
509173008611	CopC domain; Region: CopC; pfam04234
509173008612	Copper resistance protein D; Region: CopD; cl00563
509173008613	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
509173008614	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
509173008615	Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112
509173008616	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
509173008617	active site
509173008618	DNA binding site [nucleotide binding]
509173008619	Int/Topo IB signature motif; other site
509173008620	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
509173008621	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
509173008622	FMN binding site [chemical binding]; other site
509173008623	active site
509173008624	catalytic residues [active]
509173008625	substrate binding site [chemical binding]; other site
509173008626	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173008627	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173008628	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
509173008629	dimerization interface [polypeptide binding]; other site
509173008630	substrate binding pocket [chemical binding]; other site
509173008631	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
509173008632	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
509173008633	putative ATP binding site [chemical binding]; other site
509173008634	putative substrate interface [chemical binding]; other site
509173008635	aconitate hydratase; Validated; Region: PRK09277
509173008636	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
509173008637	substrate binding site [chemical binding]; other site
509173008638	ligand binding site [chemical binding]; other site
509173008639	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
509173008640	substrate binding site [chemical binding]; other site
509173008641	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
509173008642	active site
509173008643	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
509173008644	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
509173008645	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
509173008646	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
509173008647	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
509173008648	G1 box; other site
509173008649	putative GEF interaction site [polypeptide binding]; other site
509173008650	GTP/Mg2+ binding site [chemical binding]; other site
509173008651	Switch I region; other site
509173008652	G2 box; other site
509173008653	G3 box; other site
509173008654	Switch II region; other site
509173008655	G4 box; other site
509173008656	G5 box; other site
509173008657	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
509173008658	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
509173008659	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173008660	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173008661	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173008662	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
509173008663	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
509173008664	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
509173008665	metal binding site [ion binding]; metal-binding site
509173008666	active site
509173008667	I-site; other site
509173008668	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
509173008669	ketol-acid reductoisomerase; Provisional; Region: PRK05479
509173008670	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
509173008671	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
509173008672	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
509173008673	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
509173008674	putative valine binding site [chemical binding]; other site
509173008675	dimer interface [polypeptide binding]; other site
509173008676	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
509173008677	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466
509173008678	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
509173008679	PYR/PP interface [polypeptide binding]; other site
509173008680	dimer interface [polypeptide binding]; other site
509173008681	TPP binding site [chemical binding]; other site
509173008682	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
509173008683	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
509173008684	TPP-binding site [chemical binding]; other site
509173008685	dimer interface [polypeptide binding]; other site
509173008686	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
509173008687	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
509173008688	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
509173008689	HIGH motif; other site
509173008690	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
509173008691	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
509173008692	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
509173008693	active site
509173008694	KMSKS motif; other site
509173008695	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
509173008696	tRNA binding surface [nucleotide binding]; other site
509173008697	Lipopolysaccharide-assembly; Region: LptE; pfam04390
509173008698	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
509173008699	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
509173008700	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
509173008701	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173008702	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173008703	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
509173008704	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
509173008705	Walker A/P-loop; other site
509173008706	ATP binding site [chemical binding]; other site
509173008707	Q-loop/lid; other site
509173008708	ABC transporter signature motif; other site
509173008709	Walker B; other site
509173008710	D-loop; other site
509173008711	H-loop/switch region; other site
509173008712	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
509173008713	FtsX-like permease family; Region: FtsX; pfam02687
509173008714	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
509173008715	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
509173008716	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
509173008717	NAD binding site [chemical binding]; other site
509173008718	homotetramer interface [polypeptide binding]; other site
509173008719	homodimer interface [polypeptide binding]; other site
509173008720	substrate binding site [chemical binding]; other site
509173008721	active site
509173008722	Bax inhibitor 1 like; Region: BaxI_1; cl17691
509173008723	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
509173008724	catalytic site [active]
509173008725	putative active site [active]
509173008726	putative substrate binding site [chemical binding]; other site
509173008727	dimer interface [polypeptide binding]; other site
509173008728	GTPase RsgA; Reviewed; Region: PRK12288
509173008729	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
509173008730	RNA binding site [nucleotide binding]; other site
509173008731	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
509173008732	GTPase/Zn-binding domain interface [polypeptide binding]; other site
509173008733	GTP/Mg2+ binding site [chemical binding]; other site
509173008734	G4 box; other site
509173008735	G5 box; other site
509173008736	G1 box; other site
509173008737	Switch I region; other site
509173008738	G2 box; other site
509173008739	G3 box; other site
509173008740	Switch II region; other site
509173008741	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
509173008742	active site residue [active]
509173008743	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
509173008744	GSH binding site [chemical binding]; other site
509173008745	catalytic residues [active]
509173008746	preprotein translocase subunit SecB; Validated; Region: PRK05751
509173008747	SecA binding site; other site
509173008748	Preprotein binding site; other site
509173008749	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
509173008750	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
509173008751	GTP-binding protein Der; Reviewed; Region: PRK00093
509173008752	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
509173008753	G1 box; other site
509173008754	GTP/Mg2+ binding site [chemical binding]; other site
509173008755	Switch I region; other site
509173008756	G2 box; other site
509173008757	Switch II region; other site
509173008758	G3 box; other site
509173008759	G4 box; other site
509173008760	G5 box; other site
509173008761	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
509173008762	G1 box; other site
509173008763	GTP/Mg2+ binding site [chemical binding]; other site
509173008764	Switch I region; other site
509173008765	G2 box; other site
509173008766	G3 box; other site
509173008767	Switch II region; other site
509173008768	G4 box; other site
509173008769	G5 box; other site
509173008770	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
509173008771	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
509173008772	Trp docking motif [polypeptide binding]; other site
509173008773	active site
509173008774	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
509173008775	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
509173008776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
509173008777	TPR motif; other site
509173008778	binding surface
509173008779	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
509173008780	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
509173008781	dimer interface [polypeptide binding]; other site
509173008782	motif 1; other site
509173008783	active site
509173008784	motif 2; other site
509173008785	motif 3; other site
509173008786	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
509173008787	anticodon binding site; other site
509173008788	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
509173008789	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
509173008790	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
509173008791	Helix-turn-helix domain; Region: HTH_25; pfam13413
509173008792	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
509173008793	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
509173008794	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
509173008795	TPR motif; other site
509173008796	binding surface
509173008797	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
509173008798	TPR motif; other site
509173008799	binding surface
509173008800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
509173008801	binding surface
509173008802	TPR motif; other site
509173008803	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
509173008804	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173008805	FeS/SAM binding site; other site
509173008806	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
509173008807	active site
509173008808	multimer interface [polypeptide binding]; other site
509173008809	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
509173008810	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
509173008811	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
509173008812	active site
509173008813	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
509173008814	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
509173008815	carboxy-terminal protease; Provisional; Region: PRK11186
509173008816	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
509173008817	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
509173008818	protein binding site [polypeptide binding]; other site
509173008819	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
509173008820	Catalytic dyad [active]
509173008821	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
509173008822	beta-hexosaminidase; Provisional; Region: PRK05337
509173008823	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
509173008824	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
509173008825	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173008826	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
509173008827	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
509173008828	putative catalytic cysteine [active]
509173008829	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
509173008830	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
509173008831	tetrameric interface [polypeptide binding]; other site
509173008832	activator binding site; other site
509173008833	NADP binding site [chemical binding]; other site
509173008834	substrate binding site [chemical binding]; other site
509173008835	catalytic residues [active]
509173008836	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
509173008837	ATP-binding site [chemical binding]; other site
509173008838	Gluconate-6-phosphate binding site [chemical binding]; other site
509173008839	Shikimate kinase; Region: SKI; pfam01202
509173008840	GntP family permease; Region: GntP_permease; pfam02447
509173008841	fructuronate transporter; Provisional; Region: PRK10034; cl15264
509173008842	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
509173008843	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
509173008844	active site
509173008845	intersubunit interface [polypeptide binding]; other site
509173008846	catalytic residue [active]
509173008847	phosphogluconate dehydratase; Validated; Region: PRK09054
509173008848	6-phosphogluconate dehydratase; Region: edd; TIGR01196
509173008849	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
509173008850	propionate/acetate kinase; Provisional; Region: PRK12379
509173008851	phosphate acetyltransferase; Reviewed; Region: PRK05632
509173008852	DRTGG domain; Region: DRTGG; pfam07085
509173008853	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
509173008854	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
509173008855	Fumarase C-terminus; Region: Fumerase_C; pfam05683
509173008856	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
509173008857	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
509173008858	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
509173008859	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
509173008860	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173008861	Walker A motif; other site
509173008862	ATP binding site [chemical binding]; other site
509173008863	Walker B motif; other site
509173008864	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
509173008865	Clp protease; Region: CLP_protease; pfam00574
509173008866	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
509173008867	oligomer interface [polypeptide binding]; other site
509173008868	active site residues [active]
509173008869	trigger factor; Provisional; Region: tig; PRK01490
509173008870	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
509173008871	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
509173008872	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
509173008873	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173008874	N-terminal plug; other site
509173008875	ligand-binding site [chemical binding]; other site
509173008876	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
509173008877	2-isopropylmalate synthase; Validated; Region: PRK03739
509173008878	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
509173008879	active site
509173008880	catalytic residues [active]
509173008881	metal binding site [ion binding]; metal-binding site
509173008882	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
509173008883	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
509173008884	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
509173008885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173008886	S-adenosylmethionine binding site [chemical binding]; other site
509173008887	Sel1-like repeats; Region: SEL1; smart00671
509173008888	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
509173008889	Sel1-like repeats; Region: SEL1; smart00671
509173008890	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
509173008891	active site
509173008892	dimerization interface [polypeptide binding]; other site
509173008893	Membrane transport protein; Region: Mem_trans; cl09117
509173008894	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
509173008895	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
509173008896	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
509173008897	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173008898	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173008899	Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of  phospholipase D protein (part 1)
509173008900	Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of  phospholipase D protein (part 2)
509173008901	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173008902	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173008903	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
509173008904	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
509173008905	NRDE protein; Region: NRDE; cl01315
509173008906	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
509173008907	thymidylate synthase; Reviewed; Region: thyA; PRK01827
509173008908	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
509173008909	dimerization interface [polypeptide binding]; other site
509173008910	active site
509173008911	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
509173008912	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
509173008913	folate binding site [chemical binding]; other site
509173008914	NADP+ binding site [chemical binding]; other site
509173008915	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
509173008916	methionine sulfoxide reductase A; Provisional; Region: PRK14054
509173008917	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
509173008918	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
509173008919	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
509173008920	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
509173008921	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
509173008922	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
509173008923	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
509173008924	putative active site [active]
509173008925	putative substrate binding site [chemical binding]; other site
509173008926	putative cosubstrate binding site; other site
509173008927	catalytic site [active]
509173008928	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173008929	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173008930	Bacterial transcriptional repressor; Region: TetR; pfam13972
509173008931	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
509173008932	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
509173008933	NAD(P) binding site [chemical binding]; other site
509173008934	catalytic residues [active]
509173008935	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
509173008936	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
509173008937	putative cation:proton antiport protein; Provisional; Region: PRK10669
509173008938	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
509173008939	TrkA-N domain; Region: TrkA_N; pfam02254
509173008940	ASCH domain; Region: ASCH; pfam04266
509173008941	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
509173008942	RNA recognition motif; Region: RRM; smart00360
509173008943	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
509173008944	Part of AAA domain; Region: AAA_19; pfam13245
509173008945	Family description; Region: UvrD_C_2; pfam13538
509173008946	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
509173008947	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
509173008948	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
509173008949	active site
509173008950	interdomain interaction site; other site
509173008951	putative metal-binding site [ion binding]; other site
509173008952	nucleotide binding site [chemical binding]; other site
509173008953	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
509173008954	domain I; other site
509173008955	DNA binding groove [nucleotide binding]
509173008956	phosphate binding site [ion binding]; other site
509173008957	domain II; other site
509173008958	domain III; other site
509173008959	nucleotide binding site [chemical binding]; other site
509173008960	catalytic site [active]
509173008961	domain IV; other site
509173008962	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
509173008963	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
509173008964	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
509173008965	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
509173008966	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
509173008967	Predicted transcriptional regulators [Transcription]; Region: COG1733
509173008968	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
509173008969	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
509173008970	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
509173008971	putative NAD(P) binding site [chemical binding]; other site
509173008972	dimer interface [polypeptide binding]; other site
509173008973	SlyX; Region: SlyX; pfam04102
509173008974	ABC transporter ATPase component; Reviewed; Region: PRK11147
509173008975	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173008976	Walker A/P-loop; other site
509173008977	ATP binding site [chemical binding]; other site
509173008978	Q-loop/lid; other site
509173008979	ABC transporter signature motif; other site
509173008980	Walker B; other site
509173008981	D-loop; other site
509173008982	H-loop/switch region; other site
509173008983	ABC transporter; Region: ABC_tran_2; pfam12848
509173008984	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
509173008985	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173008986	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
509173008987	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
509173008988	putative acyl-acceptor binding pocket; other site
509173008989	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
509173008990	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
509173008991	putative ADP-binding pocket [chemical binding]; other site
509173008992	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
509173008993	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
509173008994	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
509173008995	putative catalytic site [active]
509173008996	putative metal binding site [ion binding]; other site
509173008997	putative phosphate binding site [ion binding]; other site
509173008998	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
509173008999	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
509173009000	FimV N-terminal domain; Region: FimV_core; TIGR03505
509173009001	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
509173009002	active site
509173009003	homodimer interface [polypeptide binding]; other site
509173009004	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
509173009005	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
509173009006	dimerization interface 3.5A [polypeptide binding]; other site
509173009007	active site
509173009008	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
509173009009	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
509173009010	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173009011	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
509173009012	rRNA binding site [nucleotide binding]; other site
509173009013	predicted 30S ribosome binding site; other site
509173009014	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
509173009015	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
509173009016	tartrate dehydrogenase; Region: TTC; TIGR02089
509173009017	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
509173009018	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
509173009019	substrate binding site [chemical binding]; other site
509173009020	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
509173009021	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
509173009022	substrate binding site [chemical binding]; other site
509173009023	ligand binding site [chemical binding]; other site
509173009024	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial)
509173009025	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173009026	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173009027	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
509173009028	dimerization interface [polypeptide binding]; other site
509173009029	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
509173009030	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
509173009031	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
509173009032	putative active site [active]
509173009033	Ap4A binding site [chemical binding]; other site
509173009034	nudix motif; other site
509173009035	putative metal binding site [ion binding]; other site
509173009036	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
509173009037	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
509173009038	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
509173009039	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
509173009040	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
509173009041	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
509173009042	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
509173009043	heme binding site [chemical binding]; other site
509173009044	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
509173009045	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
509173009046	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
509173009047	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
509173009048	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173009049	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173009050	dimerization interface [polypeptide binding]; other site
509173009051	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
509173009052	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
509173009053	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
509173009054	putative C-terminal domain interface [polypeptide binding]; other site
509173009055	putative GSH binding site (G-site) [chemical binding]; other site
509173009056	putative dimer interface [polypeptide binding]; other site
509173009057	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
509173009058	dimer interface [polypeptide binding]; other site
509173009059	N-terminal domain interface [polypeptide binding]; other site
509173009060	putative substrate binding pocket (H-site) [chemical binding]; other site
509173009061	Predicted transcriptional regulator [Transcription]; Region: COG2378
509173009062	HTH domain; Region: HTH_11; pfam08279
509173009063	WYL domain; Region: WYL; pfam13280
509173009064	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
509173009065	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173009066	motif II; other site
509173009067	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
509173009068	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
509173009069	RNA binding surface [nucleotide binding]; other site
509173009070	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
509173009071	active site
509173009072	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
509173009073	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
509173009074	homodimer interface [polypeptide binding]; other site
509173009075	oligonucleotide binding site [chemical binding]; other site
509173009076	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
509173009077	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
509173009078	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
509173009079	acyl-activating enzyme (AAE) consensus motif; other site
509173009080	putative AMP binding site [chemical binding]; other site
509173009081	putative active site [active]
509173009082	putative CoA binding site [chemical binding]; other site
509173009083	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173009084	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173009085	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
509173009086	putative effector binding pocket; other site
509173009087	putative dimerization interface [polypeptide binding]; other site
509173009088	short chain dehydrogenase; Provisional; Region: PRK12744
509173009089	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
509173009090	NADP binding site [chemical binding]; other site
509173009091	homodimer interface [polypeptide binding]; other site
509173009092	active site
509173009093	substrate binding site [chemical binding]; other site
509173009094	HemN family oxidoreductase; Provisional; Region: PRK05660
509173009095	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
509173009096	FeS/SAM binding site; other site
509173009097	HemN C-terminal domain; Region: HemN_C; pfam06969
509173009098	Protein of unknown function, DUF606; Region: DUF606; pfam04657
509173009099	multidrug efflux protein; Reviewed; Region: PRK01766
509173009100	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
509173009101	cation binding site [ion binding]; other site
509173009102	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
509173009103	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
509173009104	Flavin binding site [chemical binding]; other site
509173009105	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
509173009106	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
509173009107	Flavin binding site [chemical binding]; other site
509173009108	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
509173009109	ABC1 family; Region: ABC1; pfam03109
509173009110	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
509173009111	HopJ type III effector protein; Region: HopJ; pfam08888
509173009112	chromosome condensation membrane protein; Provisional; Region: PRK14196
509173009113	Uncharacterized conserved protein [Function unknown]; Region: COG3791
509173009114	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173009115	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
509173009116	Putative methyltransferase; Region: Methyltransf_4; cl17290
509173009117	Domain of unknown function (DUF329); Region: DUF329; pfam03884
509173009118	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
509173009119	ferrochelatase; Reviewed; Region: hemH; PRK00035
509173009120	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
509173009121	C-terminal domain interface [polypeptide binding]; other site
509173009122	active site
509173009123	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
509173009124	active site
509173009125	N-terminal domain interface [polypeptide binding]; other site
509173009126	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
509173009127	glutamate racemase; Provisional; Region: PRK00865
509173009128	aspartate racemase; Region: asp_race; TIGR00035
509173009129	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
509173009130	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
509173009131	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173009132	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
509173009133	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
509173009134	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
509173009135	CPxP  motif; other site
509173009136	FOG: CBS domain [General function prediction only]; Region: COG0517
509173009137	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
509173009138	Transporter associated domain; Region: CorC_HlyC; smart01091
509173009139	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
509173009140	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
509173009141	putative active site [active]
509173009142	catalytic triad [active]
509173009143	putative dimer interface [polypeptide binding]; other site
509173009144	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
509173009145	dimer interface [polypeptide binding]; other site
509173009146	putative tRNA-binding site [nucleotide binding]; other site
509173009147	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
509173009148	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
509173009149	type II secretion system protein F; Region: GspF; TIGR02120
509173009150	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
509173009151	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
509173009152	primosome assembly protein PriA; Validated; Region: PRK05580
509173009153	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
509173009154	ATP binding site [chemical binding]; other site
509173009155	putative Mg++ binding site [ion binding]; other site
509173009156	helicase superfamily c-terminal domain; Region: HELICc; smart00490
509173009157	ATP-binding site [chemical binding]; other site
509173009158	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
509173009159	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
509173009160	TrkA-N domain; Region: TrkA_N; pfam02254
509173009161	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
509173009162	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
509173009163	dimerization interface [polypeptide binding]; other site
509173009164	domain crossover interface; other site
509173009165	redox-dependent activation switch; other site
509173009166	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173009167	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
509173009168	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
509173009169	HSP70 interaction site [polypeptide binding]; other site
509173009170	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
509173009171	substrate binding site [polypeptide binding]; other site
509173009172	dimer interface [polypeptide binding]; other site
509173009173	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
509173009174	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
509173009175	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
509173009176	oligomer interface [polypeptide binding]; other site
509173009177	metal binding site [ion binding]; metal-binding site
509173009178	metal binding site [ion binding]; metal-binding site
509173009179	putative Cl binding site [ion binding]; other site
509173009180	aspartate ring; other site
509173009181	basic sphincter; other site
509173009182	hydrophobic gate; other site
509173009183	periplasmic entrance; other site
509173009184	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
509173009185	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
509173009186	RNase E interface [polypeptide binding]; other site
509173009187	trimer interface [polypeptide binding]; other site
509173009188	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
509173009189	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
509173009190	RNase E interface [polypeptide binding]; other site
509173009191	trimer interface [polypeptide binding]; other site
509173009192	active site
509173009193	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
509173009194	putative nucleic acid binding region [nucleotide binding]; other site
509173009195	G-X-X-G motif; other site
509173009196	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
509173009197	RNA binding site [nucleotide binding]; other site
509173009198	domain interface; other site
509173009199	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
509173009200	16S/18S rRNA binding site [nucleotide binding]; other site
509173009201	S13e-L30e interaction site [polypeptide binding]; other site
509173009202	25S rRNA binding site [nucleotide binding]; other site
509173009203	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
509173009204	Beta-lactamase; Region: Beta-lactamase; pfam00144
509173009205	AAA domain; Region: AAA_30; pfam13604
509173009206	AAA domain; Region: AAA_22; pfam13401
509173009207	Family description; Region: UvrD_C_2; pfam13538
509173009208	Part of AAA domain; Region: AAA_19; pfam13245
509173009209	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
509173009210	Family description; Region: UvrD_C_2; pfam13538
509173009211	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
509173009212	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
509173009213	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
509173009214	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
509173009215	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
509173009216	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
509173009217	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
509173009218	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
509173009219	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173009220	S-adenosylmethionine binding site [chemical binding]; other site
509173009221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
509173009222	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
509173009223	ABC1 family; Region: ABC1; cl17513
509173009224	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
509173009225	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
509173009226	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
509173009227	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
509173009228	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
509173009229	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
509173009230	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
509173009231	metal binding site [ion binding]; metal-binding site
509173009232	Family description; Region: UvrD_C_2; pfam13538
509173009233	AAA domain; Region: AAA_23; pfam13476
509173009234	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
509173009235	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
509173009236	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
509173009237	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
509173009238	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
509173009239	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
509173009240	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
509173009241	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
509173009242	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
509173009243	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
509173009244	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
509173009245	ribosome-binding factor A; Provisional; Region: PRK13816
509173009246	translation initiation factor IF-2; Region: IF-2; TIGR00487
509173009247	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
509173009248	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
509173009249	G1 box; other site
509173009250	putative GEF interaction site [polypeptide binding]; other site
509173009251	GTP/Mg2+ binding site [chemical binding]; other site
509173009252	Switch I region; other site
509173009253	G2 box; other site
509173009254	G3 box; other site
509173009255	Switch II region; other site
509173009256	G4 box; other site
509173009257	G5 box; other site
509173009258	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
509173009259	Translation-initiation factor 2; Region: IF-2; pfam11987
509173009260	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
509173009261	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
509173009262	NusA N-terminal domain; Region: NusA_N; pfam08529
509173009263	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
509173009264	RNA binding site [nucleotide binding]; other site
509173009265	homodimer interface [polypeptide binding]; other site
509173009266	NusA-like KH domain; Region: KH_5; pfam13184
509173009267	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
509173009268	G-X-X-G motif; other site
509173009269	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
509173009270	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
509173009271	Sm and related proteins; Region: Sm_like; cl00259
509173009272	ribosome maturation protein RimP; Reviewed; Region: PRK00092
509173009273	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
509173009274	putative oligomer interface [polypeptide binding]; other site
509173009275	putative RNA binding site [nucleotide binding]; other site
509173009276	Preprotein translocase SecG subunit; Region: SecG; pfam03840
509173009277	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
509173009278	triosephosphate isomerase; Provisional; Region: PRK14567
509173009279	substrate binding site [chemical binding]; other site
509173009280	dimer interface [polypeptide binding]; other site
509173009281	catalytic triad [active]
509173009282	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
509173009283	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
509173009284	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
509173009285	Walker A motif; other site
509173009286	ATP binding site [chemical binding]; other site
509173009287	Walker B motif; other site
509173009288	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
509173009289	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
509173009290	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
509173009291	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
509173009292	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
509173009293	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
509173009294	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
509173009295	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
509173009296	CoA-binding site [chemical binding]; other site
509173009297	ATP-binding [chemical binding]; other site
509173009298	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
509173009299	EamA-like transporter family; Region: EamA; pfam00892
509173009300	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
509173009301	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
509173009302	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
509173009303	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
509173009304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
509173009305	binding surface
509173009306	Tetratricopeptide repeat; Region: TPR_16; pfam13432
509173009307	TPR motif; other site
509173009308	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
509173009309	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
509173009310	Walker A/P-loop; other site
509173009311	ATP binding site [chemical binding]; other site
509173009312	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
509173009313	ABC transporter signature motif; other site
509173009314	Walker B; other site
509173009315	D-loop; other site
509173009316	H-loop/switch region; other site
509173009317	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
509173009318	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
509173009319	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
509173009320	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
509173009321	HlyD family secretion protein; Region: HlyD_3; pfam13437
509173009322	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
509173009323	Fusaric acid resistance protein family; Region: FUSC; pfam04632
509173009324	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
509173009325	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
509173009326	Transcriptional regulator [Transcription]; Region: IclR; COG1414
509173009327	Bacterial transcriptional regulator; Region: IclR; pfam01614
509173009328	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
509173009329	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173009330	Helix-turn-helix domain; Region: HTH_18; pfam12833
509173009331	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
509173009332	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
509173009333	DNA binding site [nucleotide binding]
509173009334	active site
509173009335	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
509173009336	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
509173009337	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
509173009338	active site
509173009339	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556
509173009340	active site
509173009341	dimer interface [polypeptide binding]; other site
509173009342	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
509173009343	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
509173009344	GIY-YIG motif/motif A; other site
509173009345	active site
509173009346	catalytic site [active]
509173009347	putative DNA binding site [nucleotide binding]; other site
509173009348	metal binding site [ion binding]; metal-binding site
509173009349	UvrB/uvrC motif; Region: UVR; pfam02151
509173009350	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
509173009351	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
509173009352	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
509173009353	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173009354	substrate binding site [chemical binding]; other site
509173009355	oxyanion hole (OAH) forming residues; other site
509173009356	trimer interface [polypeptide binding]; other site
509173009357	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
509173009358	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
509173009359	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
509173009360	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
509173009361	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
509173009362	dimer interface [polypeptide binding]; other site
509173009363	active site
509173009364	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
509173009365	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
509173009366	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
509173009367	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
509173009368	DNA binding residues [nucleotide binding]
509173009369	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
509173009370	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
509173009371	catalytic residues [active]
509173009372	heat shock protein 90; Provisional; Region: PRK05218
509173009373	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173009374	ATP binding site [chemical binding]; other site
509173009375	Mg2+ binding site [ion binding]; other site
509173009376	G-X-G motif; other site
509173009377	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
509173009378	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
509173009379	Predicted permease [General function prediction only]; Region: COG2056
509173009380	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
509173009381	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
509173009382	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
509173009383	active site 2 [active]
509173009384	active site 1 [active]
509173009385	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
509173009386	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
509173009387	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
509173009388	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
509173009389	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
509173009390	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
509173009391	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
509173009392	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
509173009393	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
509173009394	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
509173009395	DNA binding site [nucleotide binding]
509173009396	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
509173009397	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
509173009398	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
509173009399	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
509173009400	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
509173009401	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
509173009402	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
509173009403	RPB1 interaction site [polypeptide binding]; other site
509173009404	RPB11 interaction site [polypeptide binding]; other site
509173009405	RPB10 interaction site [polypeptide binding]; other site
509173009406	RPB3 interaction site [polypeptide binding]; other site
509173009407	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
509173009408	core dimer interface [polypeptide binding]; other site
509173009409	peripheral dimer interface [polypeptide binding]; other site
509173009410	L10 interface [polypeptide binding]; other site
509173009411	L11 interface [polypeptide binding]; other site
509173009412	putative EF-Tu interaction site [polypeptide binding]; other site
509173009413	putative EF-G interaction site [polypeptide binding]; other site
509173009414	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
509173009415	23S rRNA interface [nucleotide binding]; other site
509173009416	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
509173009417	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
509173009418	mRNA/rRNA interface [nucleotide binding]; other site
509173009419	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
509173009420	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
509173009421	23S rRNA interface [nucleotide binding]; other site
509173009422	L7/L12 interface [polypeptide binding]; other site
509173009423	putative thiostrepton binding site; other site
509173009424	L25 interface [polypeptide binding]; other site
509173009425	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
509173009426	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
509173009427	putative homodimer interface [polypeptide binding]; other site
509173009428	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
509173009429	heterodimer interface [polypeptide binding]; other site
509173009430	homodimer interface [polypeptide binding]; other site
509173009431	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
509173009432	elongation factor Tu; Reviewed; Region: PRK00049
509173009433	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
509173009434	G1 box; other site
509173009435	GEF interaction site [polypeptide binding]; other site
509173009436	GTP/Mg2+ binding site [chemical binding]; other site
509173009437	Switch I region; other site
509173009438	G2 box; other site
509173009439	G3 box; other site
509173009440	Switch II region; other site
509173009441	G4 box; other site
509173009442	G5 box; other site
509173009443	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
509173009444	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
509173009445	Antibiotic Binding Site [chemical binding]; other site
509173009446	anthranilate synthase component I; Provisional; Region: PRK13565
509173009447	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
509173009448	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
509173009449	phosphoglycolate phosphatase; Provisional; Region: PRK13222
509173009450	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173009451	motif II; other site
509173009452	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
509173009453	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
509173009454	phosphopeptide binding site; other site
509173009455	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
509173009456	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
509173009457	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
509173009458	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
509173009459	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
509173009460	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
509173009461	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
509173009462	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
509173009463	H-NS histone family; Region: Histone_HNS; pfam00816
509173009464	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
509173009465	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
509173009466	active site
509173009467	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
509173009468	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
509173009469	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
509173009470	active site
509173009471	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
509173009472	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
509173009473	domain interfaces; other site
509173009474	active site
509173009475	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
509173009476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173009477	active site
509173009478	phosphorylation site [posttranslational modification]
509173009479	intermolecular recognition site; other site
509173009480	dimerization interface [polypeptide binding]; other site
509173009481	LytTr DNA-binding domain; Region: LytTR; smart00850
509173009482	Histidine kinase; Region: His_kinase; pfam06580
509173009483	argininosuccinate lyase; Provisional; Region: PRK00855
509173009484	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
509173009485	active sites [active]
509173009486	tetramer interface [polypeptide binding]; other site
509173009487	oxidative damage protection protein; Provisional; Region: PRK05408
509173009488	transcriptional regulator PhoU; Provisional; Region: PRK11115
509173009489	PhoU domain; Region: PhoU; pfam01895
509173009490	PhoU domain; Region: PhoU; pfam01895
509173009491	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
509173009492	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
509173009493	EamA-like transporter family; Region: EamA; pfam00892
509173009494	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173009495	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173009496	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
509173009497	ThiC-associated domain; Region: ThiC-associated; pfam13667
509173009498	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
509173009499	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
509173009500	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
509173009501	dimer interface [polypeptide binding]; other site
509173009502	ADP-ribose binding site [chemical binding]; other site
509173009503	active site
509173009504	nudix motif; other site
509173009505	metal binding site [ion binding]; metal-binding site
509173009506	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
509173009507	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
509173009508	active site
509173009509	metal binding site [ion binding]; metal-binding site
509173009510	hexamer interface [polypeptide binding]; other site
509173009511	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
509173009512	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
509173009513	active site
509173009514	nucleotide binding site [chemical binding]; other site
509173009515	HIGH motif; other site
509173009516	KMSKS motif; other site
509173009517	cell division protein FtsW; Region: ftsW; TIGR02614
509173009518	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803
509173009519	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
509173009520	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
509173009521	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
509173009522	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
509173009523	G1 box; other site
509173009524	GTP/Mg2+ binding site [chemical binding]; other site
509173009525	Switch I region; other site
509173009526	G2 box; other site
509173009527	G3 box; other site
509173009528	Switch II region; other site
509173009529	G4 box; other site
509173009530	G5 box; other site
509173009531	Nucleoside recognition; Region: Gate; pfam07670
509173009532	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
509173009533	Nucleoside recognition; Region: Gate; pfam07670
509173009534	FeoA domain; Region: FeoA; pfam04023
509173009535	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
509173009536	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
509173009537	active site
509173009538	Int/Topo IB signature motif; other site
509173009539	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
509173009540	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
509173009541	dimerization domain [polypeptide binding]; other site
509173009542	dimer interface [polypeptide binding]; other site
509173009543	catalytic residues [active]
509173009544	homoserine dehydrogenase; Provisional; Region: PRK06349
509173009545	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
509173009546	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
509173009547	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
509173009548	threonine synthase; Reviewed; Region: PRK06721
509173009549	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
509173009550	homodimer interface [polypeptide binding]; other site
509173009551	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173009552	catalytic residue [active]
509173009553	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
509173009554	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
509173009555	response regulator; Provisional; Region: PRK09483
509173009556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173009557	active site
509173009558	phosphorylation site [posttranslational modification]
509173009559	intermolecular recognition site; other site
509173009560	dimerization interface [polypeptide binding]; other site
509173009561	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
509173009562	DNA binding residues [nucleotide binding]
509173009563	dimerization interface [polypeptide binding]; other site
509173009564	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
509173009565	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
509173009566	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
509173009567	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
509173009568	dimer interface [polypeptide binding]; other site
509173009569	phosphorylation site [posttranslational modification]
509173009570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
509173009571	ATP binding site [chemical binding]; other site
509173009572	Mg2+ binding site [ion binding]; other site
509173009573	G-X-G motif; other site
509173009574	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
509173009575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
509173009576	active site
509173009577	phosphorylation site [posttranslational modification]
509173009578	intermolecular recognition site; other site
509173009579	dimerization interface [polypeptide binding]; other site
509173009580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
509173009581	Walker A motif; other site
509173009582	ATP binding site [chemical binding]; other site
509173009583	Walker B motif; other site
509173009584	arginine finger; other site
509173009585	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
509173009586	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
509173009587	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
509173009588	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
509173009589	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
509173009590	Catalytic dyad [active]
509173009591	phosphoglyceromutase; Provisional; Region: PRK05434
509173009592	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
509173009593	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
509173009594	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
509173009595	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
509173009596	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
509173009597	multifunctional aminopeptidase A; Provisional; Region: PRK00913
509173009598	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
509173009599	interface (dimer of trimers) [polypeptide binding]; other site
509173009600	Substrate-binding/catalytic site; other site
509173009601	Zn-binding sites [ion binding]; other site
509173009602	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
509173009603	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
509173009604	Lumazine binding domain; Region: Lum_binding; pfam00677
509173009605	Lumazine binding domain; Region: Lum_binding; pfam00677
509173009606	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
509173009607	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
509173009608	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
509173009609	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
509173009610	catalytic motif [active]
509173009611	Zn binding site [ion binding]; other site
509173009612	RibD C-terminal domain; Region: RibD_C; cl17279
509173009613	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
509173009614	ATP cone domain; Region: ATP-cone; pfam03477
509173009615	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
509173009616	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
509173009617	Nitrogen regulatory protein P-II; Region: P-II; smart00938
509173009618	Membrane fusogenic activity; Region: BMFP; pfam04380
509173009619	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of magnesium chelatase, competence related protein (ComM)
509173009620	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
509173009621	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
509173009622	Sulfate transporter family; Region: Sulfate_transp; pfam00916
509173009623	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
509173009624	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
509173009625	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
509173009626	Transposase; Region: DDE_Tnp_ISL3; pfam01610
509173009627	lipoprotein signal peptidase; Provisional; Region: PRK14776
509173009628	Heavy-metal-associated domain; Region: HMA; pfam00403
509173009629	metal-binding site [ion binding]
509173009630	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
509173009631	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
509173009632	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
509173009633	DNA binding residues [nucleotide binding]
509173009634	dimer interface [polypeptide binding]; other site
509173009635	putative metal binding site [ion binding]; other site
509173009636	Evidence 7 : Gene remnant; Product type s : structure; fragment of conjugal transfer protein trbI
509173009637	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
509173009638	dihydropteroate synthase; Region: DHPS; TIGR01496
509173009639	substrate binding pocket [chemical binding]; other site
509173009640	dimer interface [polypeptide binding]; other site
509173009641	inhibitor binding site; inhibition site
509173009642	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
509173009643	aminoglycoside resistance protein; Provisional; Region: PRK13746
509173009644	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
509173009645	active site
509173009646	NTP binding site [chemical binding]; other site
509173009647	metal binding triad [ion binding]; metal-binding site
509173009648	antibiotic binding site [chemical binding]; other site
509173009649	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
509173009650	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
509173009651	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
509173009652	Coenzyme A binding pocket [chemical binding]; other site
509173009653	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
509173009654	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
509173009655	Coenzyme A binding pocket [chemical binding]; other site
509173009656	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
509173009657	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173009658	Coenzyme A binding pocket [chemical binding]; other site
509173009659	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of streptothricin acetyl-transferase (Sat)
509173009660	integrase/recombinase; Provisional; Region: PRK15417
509173009661	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
509173009662	Int/Topo IB signature motif; other site
509173009663	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
509173009664	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
509173009665	Integrase core domain; Region: rve; pfam00665
509173009666	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
509173009667	Phosphotransferase enzyme family; Region: APH; pfam01636
509173009668	active site
509173009669	ATP binding site [chemical binding]; other site
509173009670	antibiotic binding site [chemical binding]; other site
509173009671	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
509173009672	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
509173009673	Integrase core domain; Region: rve; pfam00665
509173009674	multiple promoter invertase; Provisional; Region: mpi; PRK13413
509173009675	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
509173009676	catalytic residues [active]
509173009677	catalytic nucleophile [active]
509173009678	Presynaptic Site I dimer interface [polypeptide binding]; other site
509173009679	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
509173009680	Synaptic Flat tetramer interface [polypeptide binding]; other site
509173009681	Synaptic Site I dimer interface [polypeptide binding]; other site
509173009682	DNA binding site [nucleotide binding]
509173009683	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
509173009684	DNA-binding interface [nucleotide binding]; DNA binding site
509173009685	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
509173009686	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
509173009687	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
509173009688	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
509173009689	Integrase core domain; Region: rve; pfam00665
509173009690	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
509173009691	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
509173009692	chloramphenicol acetyltransferase; Provisional; Region: PRK13757
509173009693	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
509173009694	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
509173009695	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
509173009696	catalytic triad [active]
509173009697	conserved cis-peptide bond; other site
509173009698	EamA-like transporter family; Region: EamA; pfam00892
509173009699	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
509173009700	EamA-like transporter family; Region: EamA; pfam00892
509173009701	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173009702	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173009703	putative substrate translocation pore; other site
509173009704	tetracycline repressor protein TetR; Provisional; Region: PRK13756
509173009705	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173009706	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
509173009707	putative transcriptional regulator MerR; Provisional; Region: PRK13752
509173009708	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
509173009709	DNA binding residues [nucleotide binding]
509173009710	dimer interface [polypeptide binding]; other site
509173009711	mercury binding site [ion binding]; other site
509173009712	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 2)
509173009713	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (part 1)
509173009714	putative mercury transport protein MerC; Provisional; Region: PRK13755
509173009715	putative mercuric reductase; Provisional; Region: PRK13748
509173009716	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
509173009717	metal-binding site [ion binding]
509173009718	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173009719	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
509173009720	transcriptional regulator MerD; Provisional; Region: PRK13749
509173009721	Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111
509173009722	DNA binding residues [nucleotide binding]
509173009723	putative dimer interface [polypeptide binding]; other site
509173009724	putative mercury resistance protein; Provisional; Region: PRK13747
509173009725	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
509173009726	dihydropteroate synthase; Region: DHPS; TIGR01496
509173009727	substrate binding pocket [chemical binding]; other site
509173009728	dimer interface [polypeptide binding]; other site
509173009729	inhibitor binding site; inhibition site
509173009730	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
509173009731	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
509173009732	folate binding site [chemical binding]; other site
509173009733	NADP+ binding site [chemical binding]; other site
509173009734	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
509173009735	Ribosomal protein S27; Region: Ribosomal_S27e; cl00897
509173009736	Putative transposase; Region: Y2_Tnp; pfam04986
509173009737	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
509173009738	dihydropteroate synthase; Region: DHPS; TIGR01496
509173009739	substrate binding pocket [chemical binding]; other site
509173009740	dimer interface [polypeptide binding]; other site
509173009741	inhibitor binding site; inhibition site
509173009742	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
509173009743	aminoglycoside resistance protein; Provisional; Region: PRK13746
509173009744	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
509173009745	active site
509173009746	NTP binding site [chemical binding]; other site
509173009747	metal binding triad [ion binding]; metal-binding site
509173009748	antibiotic binding site [chemical binding]; other site
509173009749	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
509173009750	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
509173009751	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
509173009752	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173009753	putative substrate translocation pore; other site
509173009754	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
509173009755	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
509173009756	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
509173009757	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173009758	fragment of conserved hypothetical protein (part 1);Evidence 7 : Gene remnant; Product type e : enzyme
509173009759	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
509173009760	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
509173009761	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
509173009762	generic binding surface II; other site
509173009763	DEAD-like helicases superfamily; Region: DEXDc; smart00487
509173009764	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
509173009765	ATP binding site [chemical binding]; other site
509173009766	putative Mg++ binding site [ion binding]; other site
509173009767	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
509173009768	nucleotide binding region [chemical binding]; other site
509173009769	ATP-binding site [chemical binding]; other site
509173009770	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
509173009771	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
509173009772	Coenzyme A binding pocket [chemical binding]; other site
509173009773	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of streptothricin acetyl-transferase (Sat)
509173009774	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
509173009775	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
509173009776	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173009777	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173009778	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173009779	dimerization interface [polypeptide binding]; other site
509173009780	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173009781	Major Facilitator Superfamily; Region: MFS_1; pfam07690
509173009782	putative substrate translocation pore; other site
509173009783	tetracycline repressor protein TetR; Provisional; Region: PRK13756
509173009784	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173009785	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
509173009786	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
509173009787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173009788	putative substrate translocation pore; other site
509173009789	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Dihydropteroate synthase type-1 (Dihydropteroate synthase type I) (DHPS) (Dihydropteroate pyrophosphorylase type I) (SulI)
509173009790	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
509173009791	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
509173009792	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
509173009793	folate binding site [chemical binding]; other site
509173009794	NADP+ binding site [chemical binding]; other site
509173009795	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of streptothricin acetyl-transferase (Sat)
509173009796	integrase/recombinase; Provisional; Region: PRK15417
509173009797	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
509173009798	Int/Topo IB signature motif; other site
509173009799	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
509173009800	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
509173009801	Phosphotransferase enzyme family; Region: APH; pfam01636
509173009802	active site
509173009803	ATP binding site [chemical binding]; other site
509173009804	antibiotic binding site [chemical binding]; other site
509173009805	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of Streptomycin 3''-adenylyltransferase
509173009806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
509173009807	Transposase; Region: DDE_Tnp_ISL3; pfam01610
509173009808	lipoprotein signal peptidase; Provisional; Region: PRK14776
509173009809	Heavy-metal-associated domain; Region: HMA; pfam00403
509173009810	metal-binding site [ion binding]
509173009811	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
509173009812	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
509173009813	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
509173009814	DNA binding residues [nucleotide binding]
509173009815	dimer interface [polypeptide binding]; other site
509173009816	putative metal binding site [ion binding]; other site
509173009817	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
509173009818	Ligand Binding Site [chemical binding]; other site
509173009819	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
509173009820	ArsC family; Region: ArsC; pfam03960
509173009821	catalytic residues [active]
509173009822	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173009823	dimerization interface [polypeptide binding]; other site
509173009824	putative DNA binding site [nucleotide binding]; other site
509173009825	putative Zn2+ binding site [ion binding]; other site
509173009826	Low molecular weight phosphatase family; Region: LMWPc; cd00115
509173009827	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
509173009828	active site
509173009829	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
509173009830	arsenical-resistance protein; Region: acr3; TIGR00832
509173009831	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
509173009832	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
509173009833	thioredoxin reductase; Provisional; Region: PRK10262
509173009834	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
509173009835	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173009836	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
509173009837	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
509173009838	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14811
509173009839	Bacterial TniB protein; Region: TniB; pfam05621
509173009840	AAA domain; Region: AAA_22; pfam13401
509173009841	Helix-turn-helix domain; Region: HTH_28; pfam13518
509173009842	Integrase core domain; Region: rve; pfam00665
509173009843	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
509173009844	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
509173009845	Evidence 7 : Gene remnant; Product type e : enzyme; fragment of magnesium chelatase, competence related protein (ComM)
509173009846	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173009847	DNA-binding site [nucleotide binding]; DNA binding site
509173009848	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
509173009849	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173009850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173009851	homodimer interface [polypeptide binding]; other site
509173009852	catalytic residue [active]
509173009853	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
509173009854	intersubunit interface [polypeptide binding]; other site
509173009855	active site
509173009856	Zn2+ binding site [ion binding]; other site
509173009857	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
509173009858	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
509173009859	inhibitor site; inhibition site
509173009860	active site
509173009861	dimer interface [polypeptide binding]; other site
509173009862	catalytic residue [active]
509173009863	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
509173009864	outer membrane porin, OprD family; Region: OprD; pfam03573
509173009865	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
509173009866	dimer interface [polypeptide binding]; other site
509173009867	substrate binding site [chemical binding]; other site
509173009868	metal binding sites [ion binding]; metal-binding site
509173009869	MAPEG family; Region: MAPEG; cl09190
509173009870	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
509173009871	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
509173009872	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
509173009873	acyl-activating enzyme (AAE) consensus motif; other site
509173009874	putative AMP binding site [chemical binding]; other site
509173009875	putative active site [active]
509173009876	putative CoA binding site [chemical binding]; other site
509173009877	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
509173009878	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
509173009879	CAP-like domain; other site
509173009880	active site
509173009881	primary dimer interface [polypeptide binding]; other site
509173009882	benzoate transport; Region: 2A0115; TIGR00895
509173009883	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173009884	putative substrate translocation pore; other site
509173009885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173009886	Predicted membrane protein [Function unknown]; Region: COG2860
509173009887	UPF0126 domain; Region: UPF0126; pfam03458
509173009888	UPF0126 domain; Region: UPF0126; pfam03458
509173009889	hypothetical protein; Provisional; Region: PRK01752
509173009890	SEC-C motif; Region: SEC-C; pfam02810
509173009891	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
509173009892	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
509173009893	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
509173009894	Transporter associated domain; Region: CorC_HlyC; smart01091
509173009895	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
509173009896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173009897	putative transporter; Provisional; Region: PRK10504
509173009898	putative substrate translocation pore; other site
509173009899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173009900	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
509173009901	active site
509173009902	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
509173009903	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
509173009904	active site
509173009905	DNA polymerase IV; Validated; Region: PRK02406
509173009906	DNA binding site [nucleotide binding]
509173009907	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
509173009908	homotrimer interaction site [polypeptide binding]; other site
509173009909	putative active site [active]
509173009910	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
509173009911	hypothetical protein; Provisional; Region: PRK01254
509173009912	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
509173009913	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
509173009914	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
509173009915	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
509173009916	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
509173009917	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
509173009918	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
509173009919	DNA binding residues [nucleotide binding]
509173009920	putative dimer interface [polypeptide binding]; other site
509173009921	putative metal binding residues [ion binding]; other site
509173009922	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
509173009923	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
509173009924	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
509173009925	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
509173009926	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
509173009927	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
509173009928	N-acetyl-D-glucosamine binding site [chemical binding]; other site
509173009929	catalytic residue [active]
509173009930	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
509173009931	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
509173009932	dimer interface [polypeptide binding]; other site
509173009933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173009934	catalytic residue [active]
509173009935	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173009936	Coenzyme A binding pocket [chemical binding]; other site
509173009937	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173009938	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173009939	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
509173009940	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial)
509173009941	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
509173009942	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173009943	N-terminal plug; other site
509173009944	ligand-binding site [chemical binding]; other site
509173009945	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
509173009946	active site
509173009947	catalytic residues [active]
509173009948	metal binding site [ion binding]; metal-binding site
509173009949	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
509173009950	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
509173009951	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
509173009952	DNA protecting protein DprA; Region: dprA; TIGR00732
509173009953	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
509173009954	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
509173009955	EamA-like transporter family; Region: EamA; pfam00892
509173009956	EamA-like transporter family; Region: EamA; pfam00892
509173009957	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173009958	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173009959	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
509173009960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173009961	putative substrate translocation pore; other site
509173009962	Helix-turn-helix domain; Region: HTH_18; pfam12833
509173009963	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
509173009964	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
509173009965	catalytic residues [active]
509173009966	dimer interface [polypeptide binding]; other site
509173009967	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
509173009968	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
509173009969	gamma subunit interface [polypeptide binding]; other site
509173009970	epsilon subunit interface [polypeptide binding]; other site
509173009971	LBP interface [polypeptide binding]; other site
509173009972	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
509173009973	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
509173009974	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
509173009975	alpha subunit interaction interface [polypeptide binding]; other site
509173009976	Walker A motif; other site
509173009977	ATP binding site [chemical binding]; other site
509173009978	Walker B motif; other site
509173009979	inhibitor binding site; inhibition site
509173009980	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
509173009981	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
509173009982	core domain interface [polypeptide binding]; other site
509173009983	delta subunit interface [polypeptide binding]; other site
509173009984	epsilon subunit interface [polypeptide binding]; other site
509173009985	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
509173009986	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
509173009987	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
509173009988	Walker A motif; other site
509173009989	ATP binding site [chemical binding]; other site
509173009990	Walker B motif; other site
509173009991	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
509173009992	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
509173009993	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
509173009994	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
509173009995	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
509173009996	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
509173009997	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
509173009998	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
509173009999	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
509173010000	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
509173010001	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
509173010002	intersubunit interface [polypeptide binding]; other site
509173010003	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
509173010004	metal binding site 2 [ion binding]; metal-binding site
509173010005	putative DNA binding helix; other site
509173010006	metal binding site 1 [ion binding]; metal-binding site
509173010007	dimer interface [polypeptide binding]; other site
509173010008	structural Zn2+ binding site [ion binding]; other site
509173010009	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
509173010010	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
509173010011	Walker A/P-loop; other site
509173010012	ATP binding site [chemical binding]; other site
509173010013	Q-loop/lid; other site
509173010014	ABC transporter signature motif; other site
509173010015	Walker B; other site
509173010016	D-loop; other site
509173010017	H-loop/switch region; other site
509173010018	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
509173010019	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
509173010020	ABC-ATPase subunit  interface; other site
509173010021	dimer interface [polypeptide binding]; other site
509173010022	putative PBP binding regions; other site
509173010023	LysE type translocator; Region: LysE; cl00565
509173010024	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
509173010025	malate dehydrogenase; Provisional; Region: PRK13529
509173010026	Malic enzyme, N-terminal domain; Region: malic; pfam00390
509173010027	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
509173010028	NAD(P) binding site [chemical binding]; other site
509173010029	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
509173010030	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
509173010031	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
509173010032	active site
509173010033	HIGH motif; other site
509173010034	nucleotide binding site [chemical binding]; other site
509173010035	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
509173010036	KMSK motif region; other site
509173010037	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
509173010038	tRNA binding surface [nucleotide binding]; other site
509173010039	anticodon binding site; other site
509173010040	Sporulation related domain; Region: SPOR; pfam05036
509173010041	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
509173010042	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
509173010043	putative C-terminal domain interface [polypeptide binding]; other site
509173010044	putative GSH binding site (G-site) [chemical binding]; other site
509173010045	putative dimer interface [polypeptide binding]; other site
509173010046	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
509173010047	putative N-terminal domain interface [polypeptide binding]; other site
509173010048	putative dimer interface [polypeptide binding]; other site
509173010049	putative substrate binding pocket (H-site) [chemical binding]; other site
509173010050	OsmC-like protein; Region: OsmC; pfam02566
509173010051	Pirin; Region: Pirin; pfam02678
509173010052	Pirin-related protein [General function prediction only]; Region: COG1741
509173010053	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
509173010054	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
509173010055	Predicted transcriptional regulators [Transcription]; Region: COG1695
509173010056	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
509173010057	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
509173010058	active site
509173010059	NTP binding site [chemical binding]; other site
509173010060	metal binding triad [ion binding]; metal-binding site
509173010061	antibiotic binding site [chemical binding]; other site
509173010062	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
509173010063	GMP synthase; Reviewed; Region: guaA; PRK00074
509173010064	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
509173010065	AMP/PPi binding site [chemical binding]; other site
509173010066	candidate oxyanion hole; other site
509173010067	catalytic triad [active]
509173010068	potential glutamine specificity residues [chemical binding]; other site
509173010069	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
509173010070	ATP Binding subdomain [chemical binding]; other site
509173010071	Ligand Binding sites [chemical binding]; other site
509173010072	Dimerization subdomain; other site
509173010073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
509173010074	Predicted membrane protein [Function unknown]; Region: COG2259
509173010075	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
509173010076	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
509173010077	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
509173010078	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
509173010079	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
509173010080	P-loop; other site
509173010081	Magnesium ion binding site [ion binding]; other site
509173010082	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
509173010083	Magnesium ion binding site [ion binding]; other site
509173010084	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
509173010085	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
509173010086	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
509173010087	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173010088	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
509173010089	NAD(P) binding site [chemical binding]; other site
509173010090	active site
509173010091	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
509173010092	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
509173010093	catalytic site [active]
509173010094	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
509173010095	hydrophobic ligand binding site; other site
509173010096	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
509173010097	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
509173010098	Condensation domain; Region: Condensation; pfam00668
509173010099	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
509173010100	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
509173010101	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
509173010102	acyl-activating enzyme (AAE) consensus motif; other site
509173010103	AMP binding site [chemical binding]; other site
509173010104	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
509173010105	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
509173010106	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
509173010107	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173010108	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
509173010109	active site
509173010110	acyl-CoA synthetase; Validated; Region: PRK05850
509173010111	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
509173010112	acyl-activating enzyme (AAE) consensus motif; other site
509173010113	active site
509173010114	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
509173010115	Autoinducer binding domain; Region: Autoind_bind; pfam03472
509173010116	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
509173010117	DNA binding residues [nucleotide binding]
509173010118	dimerization interface [polypeptide binding]; other site
509173010119	Autoinducer synthetase; Region: Autoind_synth; cl17404
509173010120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
509173010121	metabolite-proton symporter; Region: 2A0106; TIGR00883
509173010122	putative substrate translocation pore; other site
509173010123	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
509173010124	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173010125	substrate binding site [chemical binding]; other site
509173010126	oxyanion hole (OAH) forming residues; other site
509173010127	trimer interface [polypeptide binding]; other site
509173010128	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
509173010129	enoyl-CoA hydratase; Provisional; Region: PRK05862
509173010130	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
509173010131	substrate binding site [chemical binding]; other site
509173010132	oxyanion hole (OAH) forming residues; other site
509173010133	trimer interface [polypeptide binding]; other site
509173010134	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
509173010135	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
509173010136	active site
509173010137	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
509173010138	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
509173010139	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
509173010140	acyl-activating enzyme (AAE) consensus motif; other site
509173010141	AMP binding site [chemical binding]; other site
509173010142	active site
509173010143	CoA binding site [chemical binding]; other site
509173010144	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
509173010145	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
509173010146	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
509173010147	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
509173010148	tetrameric interface [polypeptide binding]; other site
509173010149	NAD binding site [chemical binding]; other site
509173010150	catalytic residues [active]
509173010151	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173010152	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173010153	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
509173010154	dimerization interface [polypeptide binding]; other site
509173010155	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
509173010156	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
509173010157	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
509173010158	homotrimer interaction site [polypeptide binding]; other site
509173010159	putative active site [active]
509173010160	alanine racemase; Reviewed; Region: dadX; PRK03646
509173010161	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
509173010162	active site
509173010163	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
509173010164	substrate binding site [chemical binding]; other site
509173010165	catalytic residues [active]
509173010166	dimer interface [polypeptide binding]; other site
509173010167	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
509173010168	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
509173010169	mRNA stabilisation; Region: mRNA_stabil; pfam13929
509173010170	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
509173010171	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
509173010172	putative DNA binding site [nucleotide binding]; other site
509173010173	putative Zn2+ binding site [ion binding]; other site
509173010174	AsnC family; Region: AsnC_trans_reg; pfam01037
509173010175	Predicted membrane protein [Function unknown]; Region: COG3503
509173010176	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
509173010177	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
509173010178	N-terminal plug; other site
509173010179	ligand-binding site [chemical binding]; other site
509173010180	SnoaL-like domain; Region: SnoaL_2; pfam12680
509173010181	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
509173010182	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
509173010183	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
509173010184	active site
509173010185	Predicted membrane protein [Function unknown]; Region: COG4420
509173010186	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173010187	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173010188	NAD(P) binding site [chemical binding]; other site
509173010189	active site
509173010190	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
509173010191	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
509173010192	nudix motif; other site
509173010193	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
509173010194	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
509173010195	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
509173010196	substrate binding site [chemical binding]; other site
509173010197	ligand binding site [chemical binding]; other site
509173010198	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
509173010199	substrate binding site [chemical binding]; other site
509173010200	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
509173010201	methylcitrate synthase; Provisional; Region: PRK12351
509173010202	oxalacetate binding site [chemical binding]; other site
509173010203	citrylCoA binding site [chemical binding]; other site
509173010204	coenzyme A binding site [chemical binding]; other site
509173010205	catalytic triad [active]
509173010206	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
509173010207	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
509173010208	tetramer interface [polypeptide binding]; other site
509173010209	active site
509173010210	Mg2+/Mn2+ binding site [ion binding]; other site
509173010211	Transcriptional regulators [Transcription]; Region: GntR; COG1802
509173010212	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173010213	DNA-binding site [nucleotide binding]; DNA binding site
509173010214	FCD domain; Region: FCD; pfam07729
509173010215	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
509173010216	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
509173010217	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173010218	homodimer interface [polypeptide binding]; other site
509173010219	catalytic residue [active]
509173010220	D-lactate dehydrogenase; Provisional; Region: PRK11183
509173010221	FAD binding domain; Region: FAD_binding_4; pfam01565
509173010222	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
509173010223	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
509173010224	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
509173010225	active site
509173010226	substrate binding site [chemical binding]; other site
509173010227	FMN binding site [chemical binding]; other site
509173010228	putative catalytic residues [active]
509173010229	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
509173010230	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
509173010231	DNA-binding site [nucleotide binding]; DNA binding site
509173010232	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
509173010233	L-lactate permease; Provisional; Region: PRK10420
509173010234	glycolate transporter; Provisional; Region: PRK09695
509173010235	phosphomannomutase CpsG; Provisional; Region: PRK15414
509173010236	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
509173010237	active site
509173010238	substrate binding site [chemical binding]; other site
509173010239	metal binding site [ion binding]; metal-binding site
509173010240	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
509173010241	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
509173010242	active site
509173010243	dimer interface [polypeptide binding]; other site
509173010244	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
509173010245	dimer interface [polypeptide binding]; other site
509173010246	active site
509173010247	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
509173010248	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
509173010249	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
509173010250	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
509173010251	active site
509173010252	tetramer interface; other site
509173010253	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
509173010254	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
509173010255	NAD binding site [chemical binding]; other site
509173010256	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
509173010257	NAD(P) binding site [chemical binding]; other site
509173010258	homodimer interface [polypeptide binding]; other site
509173010259	substrate binding site [chemical binding]; other site
509173010260	active site
509173010261	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
509173010262	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
509173010263	inhibitor-cofactor binding pocket; inhibition site
509173010264	pyridoxal 5'-phosphate binding site [chemical binding]; other site
509173010265	catalytic residue [active]
509173010266	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
509173010267	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
509173010268	putative trimer interface [polypeptide binding]; other site
509173010269	putative CoA binding site [chemical binding]; other site
509173010270	Bacterial sugar transferase; Region: Bac_transf; pfam02397
509173010271	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
509173010272	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
509173010273	putative ADP-binding pocket [chemical binding]; other site
509173010274	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
509173010275	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
509173010276	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
509173010277	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
509173010278	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
509173010279	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
509173010280	NAD binding site [chemical binding]; other site
509173010281	substrate binding site [chemical binding]; other site
509173010282	homodimer interface [polypeptide binding]; other site
509173010283	active site
509173010284	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
509173010285	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
509173010286	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
509173010287	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
509173010288	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
509173010289	Low molecular weight phosphatase family; Region: LMWPc; cd00115
509173010290	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
509173010291	active site
509173010292	tyrosine kinase; Provisional; Region: PRK11519
509173010293	Chain length determinant protein; Region: Wzz; pfam02706
509173010294	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
509173010295	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
509173010296	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
509173010297	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
509173010298	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
509173010299	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
509173010300	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
509173010301	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
509173010302	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
509173010303	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
509173010304	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
509173010305	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
509173010306	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
509173010307	amidase catalytic site [active]
509173010308	Zn binding residues [ion binding]; other site
509173010309	substrate binding site [chemical binding]; other site
509173010310	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
509173010311	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
509173010312	dimerization interface [polypeptide binding]; other site
509173010313	active site
509173010314	Evidence 7 : Gene remnant; fragment of conserved hypothetical protein (partial)
509173010315	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
509173010316	Phosphoesterase family; Region: Phosphoesterase; pfam04185
509173010317	Domain of unknown function (DUF756); Region: DUF756; pfam05506
509173010318	Domain of unknown function (DUF756); Region: DUF756; pfam05506
509173010319	ribonuclease PH; Reviewed; Region: rph; PRK00173
509173010320	Ribonuclease PH; Region: RNase_PH_bact; cd11362
509173010321	hexamer interface [polypeptide binding]; other site
509173010322	active site
509173010323	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
509173010324	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
509173010325	putative di-iron ligands [ion binding]; other site
509173010326	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
509173010327	FMN reductase; Validated; Region: fre; PRK08051
509173010328	FAD binding pocket [chemical binding]; other site
509173010329	FAD binding motif [chemical binding]; other site
509173010330	phosphate binding motif [ion binding]; other site
509173010331	beta-alpha-beta structure motif; other site
509173010332	NAD binding pocket [chemical binding]; other site
509173010333	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
509173010334	catalytic loop [active]
509173010335	iron binding site [ion binding]; other site
509173010336	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
509173010337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173010338	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
509173010339	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173010340	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
509173010341	catalytic residues [active]
509173010342	hinge region; other site
509173010343	alpha helical domain; other site
509173010344	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
509173010345	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
509173010346	S-adenosylmethionine binding site [chemical binding]; other site
509173010347	phosphoglycolate phosphatase; Provisional; Region: PRK13222
509173010348	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
509173010349	active site
509173010350	motif I; other site
509173010351	motif II; other site
509173010352	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
509173010353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
509173010354	NAD(P) binding site [chemical binding]; other site
509173010355	active site
509173010356	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
509173010357	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
509173010358	N-acetylglutamate synthase; Validated; Region: PRK05279
509173010359	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
509173010360	putative feedback inhibition sensing region; other site
509173010361	putative nucleotide binding site [chemical binding]; other site
509173010362	putative substrate binding site [chemical binding]; other site
509173010363	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
509173010364	Coenzyme A binding pocket [chemical binding]; other site
509173010365	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
509173010366	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
509173010367	substrate binding pocket [chemical binding]; other site
509173010368	membrane-bound complex binding site; other site
509173010369	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
509173010370	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
509173010371	substrate binding pocket [chemical binding]; other site
509173010372	membrane-bound complex binding site; other site
509173010373	hinge residues; other site
509173010374	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
509173010375	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
509173010376	active site
509173010377	dimer interface [polypeptide binding]; other site
509173010378	non-prolyl cis peptide bond; other site
509173010379	insertion regions; other site
509173010380	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
509173010381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
509173010382	putative PBP binding loops; other site
509173010383	dimer interface [polypeptide binding]; other site
509173010384	ABC-ATPase subunit interface; other site
509173010385	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
509173010386	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
509173010387	Walker A/P-loop; other site
509173010388	ATP binding site [chemical binding]; other site
509173010389	Q-loop/lid; other site
509173010390	ABC transporter signature motif; other site
509173010391	Walker B; other site
509173010392	D-loop; other site
509173010393	H-loop/switch region; other site
509173010394	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
509173010395	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
509173010396	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
509173010397	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
509173010398	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
509173010399	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
509173010400	gating phenylalanine in ion channel; other site
509173010401	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173010402	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173010403	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
509173010404	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
509173010405	active site
509173010406	Riboflavin kinase; Region: Flavokinase; smart00904
509173010407	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
509173010408	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
509173010409	active site
509173010410	HIGH motif; other site
509173010411	nucleotide binding site [chemical binding]; other site
509173010412	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
509173010413	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
509173010414	active site
509173010415	KMSKS motif; other site
509173010416	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
509173010417	tRNA binding surface [nucleotide binding]; other site
509173010418	anticodon binding site; other site
509173010419	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
509173010420	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
509173010421	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
509173010422	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
509173010423	Predicted flavoprotein [General function prediction only]; Region: COG0431
509173010424	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
509173010425	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
509173010426	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
509173010427	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
509173010428	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
509173010429	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
509173010430	substrate binding site [chemical binding]; other site
509173010431	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
509173010432	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
509173010433	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
509173010434	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
509173010435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
509173010436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
509173010437	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
509173010438	putative effector binding pocket; other site
509173010439	dimerization interface [polypeptide binding]; other site
509173010440	GrpE; Region: GrpE; pfam01025
509173010441	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
509173010442	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
509173010443	dimer interface [polypeptide binding]; other site
509173010444	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
509173010445	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
509173010446	nucleotide binding site [chemical binding]; other site
509173010447	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
509173010448	active site
509173010449	Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388
509173010450	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
509173010451	active site
509173010452	Transglycosylase SLT domain; Region: SLT_2; pfam13406
509173010453	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
509173010454	N-acetyl-D-glucosamine binding site [chemical binding]; other site
509173010455	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
509173010456	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
509173010457	ATP-grasp domain; Region: ATP-grasp; pfam02222
509173010458	AIR carboxylase; Region: AIRC; pfam00731
509173010459	Protein of unknown function, DUF486; Region: DUF486; cl01236
509173010460	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
509173010461	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
509173010462	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
509173010463	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
509173010464	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
509173010465	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
509173010466	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
509173010467	active site
509173010468	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
509173010469	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
509173010470	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
509173010471	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
509173010472	[2Fe-2S] cluster binding site [ion binding]; other site
509173010473	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
509173010474	hydrophobic ligand binding site; other site
509173010475	guanine deaminase; Provisional; Region: PRK09228
509173010476	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
509173010477	active site
509173010478	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
509173010479	active site
509173010480	Predicted membrane protein [Function unknown]; Region: COG2261
509173010481	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
509173010482	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
509173010483	dimerization domain [polypeptide binding]; other site
509173010484	dimer interface [polypeptide binding]; other site
509173010485	catalytic residues [active]
509173010486	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173010487	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173010488	Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of  phospholipase D protein (part 1)
509173010489	Evidence 7 : Gene remnant; Product type pe : enzyme; fragment of  phospholipase D protein (part 2)
509173010490	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173010491	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
509173010492	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
509173010493	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
509173010494	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
509173010495	putative metal binding site [ion binding]; other site
509173010496	putative homodimer interface [polypeptide binding]; other site
509173010497	putative homotetramer interface [polypeptide binding]; other site
509173010498	putative homodimer-homodimer interface [polypeptide binding]; other site
509173010499	putative allosteric switch controlling residues; other site
509173010500	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
509173010501	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
509173010502	trmE is a tRNA modification GTPase; Region: trmE; cd04164
509173010503	G1 box; other site
509173010504	GTP/Mg2+ binding site [chemical binding]; other site
509173010505	Switch I region; other site
509173010506	G2 box; other site
509173010507	Switch II region; other site
509173010508	G3 box; other site
509173010509	G4 box; other site
509173010510	G5 box; other site
509173010511	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
509173010512	membrane protein insertase; Provisional; Region: PRK01318
509173010513	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
509173010514	hypothetical protein; Provisional; Region: PRK14386
509173010515	Ribonuclease P; Region: Ribonuclease_P; pfam00825
509173010516	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399