-- dump date   	20140618_185601
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
232721000001	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
232721000002	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
232721000003	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
232721000004	F plasmid transfer operon protein; Region: TraF; pfam13728
232721000005	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
232721000006	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
232721000007	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
232721000008	conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876
232721000009	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
232721000010	TraU protein; Region: TraU; pfam06834
232721000011	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
232721000012	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
232721000013	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
232721000014	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
232721000015	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
232721000016	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
232721000017	type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747
232721000018	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
232721000019	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
232721000020	dimerization domain [polypeptide binding]; other site
232721000021	dimer interface [polypeptide binding]; other site
232721000022	catalytic residues [active]
232721000023	conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729
232721000024	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
232721000025	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
232721000026	TraK protein; Region: TraK; pfam06586
232721000027	TraE protein; Region: TraE; cl05060
232721000028	TraL protein; Region: TraL; cl06278
232721000029	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
232721000030	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721000031	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721000032	catalytic residue [active]
232721000033	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
232721000034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721000035	active site
232721000036	phosphorylation site [posttranslational modification]
232721000037	intermolecular recognition site; other site
232721000038	dimerization interface [polypeptide binding]; other site
232721000039	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
232721000040	DNA binding residues [nucleotide binding]
232721000041	dimerization interface [polypeptide binding]; other site
232721000042	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
232721000043	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
232721000044	Histidine kinase; Region: HisKA_3; pfam07730
232721000045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721000046	ATP binding site [chemical binding]; other site
232721000047	Mg2+ binding site [ion binding]; other site
232721000048	G-X-G motif; other site
232721000049	Domain of unknown function (DUF1805); Region: DUF1805; pfam08827
232721000050	YheO-like PAS domain; Region: PAS_6; pfam08348
232721000051	TrwC relaxase; Region: TrwC; pfam08751
232721000052	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
232721000053	AAA domain; Region: AAA_30; pfam13604
232721000054	Family description; Region: UvrD_C_2; pfam13538
232721000055	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
232721000056	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
232721000057	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
232721000058	Walker A motif; other site
232721000059	ATP binding site [chemical binding]; other site
232721000060	Walker B motif; other site
232721000061	multiple promoter invertase; Provisional; Region: mpi; PRK13413
232721000062	Resolvase, N terminal domain; Region: Resolvase; pfam00239
232721000063	catalytic residues [active]
232721000064	catalytic nucleophile [active]
232721000065	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
232721000066	MPN+ (JAMM) motif; other site
232721000067	Zinc-binding site [ion binding]; other site
232721000068	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
232721000069	BH3 interacting domain (BID); Region: BID; pfam06393
232721000070	Methyltransferase domain; Region: Methyltransf_31; pfam13847
232721000071	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721000072	S-adenosylmethionine binding site [chemical binding]; other site
232721000073	Domain of unknown function (DUF932); Region: DUF932; pfam06067
232721000074	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
232721000075	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
232721000076	dimer interface [polypeptide binding]; other site
232721000077	ssDNA binding site [nucleotide binding]; other site
232721000078	tetramer (dimer of dimers) interface [polypeptide binding]; other site
232721000079	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
232721000080	PLD-like domain; Region: PLDc_2; pfam13091
232721000081	putative active site [active]
232721000082	catalytic site [active]
232721000083	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
232721000084	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
232721000085	cofactor binding site; other site
232721000086	DNA binding site [nucleotide binding]
232721000087	substrate interaction site [chemical binding]; other site
232721000088	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
232721000089	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
232721000090	active site
232721000091	catalytic site [active]
232721000092	substrate binding site [chemical binding]; other site
232721000093	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
232721000094	Replication initiator protein A; Region: RPA; pfam10134
232721000095	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
232721000096	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
232721000097	ParB-like nuclease domain; Region: ParBc; pfam02195
232721000098	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721000099	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
232721000100	P-loop; other site
232721000101	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
232721000102	Magnesium ion binding site [ion binding]; other site
232721000103	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721000104	Magnesium ion binding site [ion binding]; other site
232721000105	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
232721000106	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
232721000107	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
232721000108	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
232721000109	catalytic motif [active]
232721000110	Catalytic residue [active]
232721000111	Nuclease-related domain; Region: NERD; pfam08378
232721000112	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
232721000113	PLD-like domain; Region: PLDc_2; pfam13091
232721000114	putative homodimer interface [polypeptide binding]; other site
232721000115	putative active site [active]
232721000116	catalytic site [active]
232721000117	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
232721000118	ligand binding site [chemical binding]; other site
232721000119	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
232721000120	IHF dimer interface [polypeptide binding]; other site
232721000121	IHF - DNA interface [nucleotide binding]; other site
232721000122	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
232721000123	Zeta toxin; Region: Zeta_toxin; pfam06414
232721000124	Fic/DOC family; Region: Fic; cl00960
232721000125	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
232721000126	FIC domain binding interface [polypeptide binding]; other site
232721000127	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
232721000128	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
232721000129	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
232721000130	Protein of unknown function, DUF462; Region: DUF462; cl01190
232721000131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
232721000132	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
232721000133	active site
232721000134	metal binding site [ion binding]; metal-binding site
232721000135	interdomain interaction site; other site
232721000136	multiple promoter invertase; Provisional; Region: mpi; PRK13413
232721000137	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
232721000138	catalytic residues [active]
232721000139	catalytic nucleophile [active]
232721000140	Presynaptic Site I dimer interface [polypeptide binding]; other site
232721000141	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
232721000142	Synaptic Flat tetramer interface [polypeptide binding]; other site
232721000143	Synaptic Site I dimer interface [polypeptide binding]; other site
232721000144	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
232721000145	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
232721000146	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
232721000147	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
232721000148	cofactor binding site; other site
232721000149	DNA binding site [nucleotide binding]
232721000150	substrate interaction site [chemical binding]; other site
232721000151	NgoMIV restriction enzyme; Region: NgoMIV_restric; pfam09015
232721000152	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
232721000153	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
232721000154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721000155	S-adenosylmethionine binding site [chemical binding]; other site
232721000156	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
232721000157	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
232721000158	ligand binding site [chemical binding]; other site
232721000159	conjugal transfer protein TrbP; Provisional; Region: PRK13882
232721000160	TraX protein; Region: TraX; pfam05857
232721000161	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721000162	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721000163	catalytic residue [active]
232721000164	conjugal transfer protein TrbM; Provisional; Region: PRK13893
232721000165	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
232721000166	entry exclusion lipoprotein TrbK; Region: TrbK_RP4; TIGR04359
232721000167	conjugal transfer protein TrbJ; Provisional; Region: PRK13879
232721000168	conjugal transfer protein TrbI; Provisional; Region: PRK13881
232721000169	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
232721000170	conjugal transfer protein TrbH; Provisional; Region: PRK13883
232721000171	Conjugal transfer protein TrbH; Region: TrbH; pfam07283
232721000172	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
232721000173	VirB7 interaction site; other site
232721000174	conjugal transfer protein TrbF; Provisional; Region: PRK13887
232721000175	conjugal transfer protein TrbE; Provisional; Region: PRK13891
232721000176	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
232721000177	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
232721000178	Walker A motif; other site
232721000179	ATP binding site [chemical binding]; other site
232721000180	Walker B motif; other site
232721000181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721000182	Walker B; other site
232721000183	D-loop; other site
232721000184	H-loop/switch region; other site
232721000185	conjugal transfer protein TrbD; Provisional; Region: PRK13823
232721000186	conjugal transfer protein TrbC; Provisional; Region: PRK13892
232721000187	conjugal transfer ATPase TrbB; Provisional; Region: PRK13894
232721000188	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
232721000189	ATP binding site [chemical binding]; other site
232721000190	Walker A motif; other site
232721000191	hexamer interface [polypeptide binding]; other site
232721000192	Walker B motif; other site
232721000193	conjugal transfer protein TrbA; Provisional; Region: PRK13890
232721000194	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721000195	salt bridge; other site
232721000196	non-specific DNA binding site [nucleotide binding]; other site
232721000197	sequence-specific DNA binding site [nucleotide binding]; other site
232721000198	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
232721000199	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
232721000200	dimer interface [polypeptide binding]; other site
232721000201	ssDNA binding site [nucleotide binding]; other site
232721000202	tetramer (dimer of dimers) interface [polypeptide binding]; other site
232721000203	TrfA protein; Region: TrfA; pfam07042
232721000204	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
232721000205	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
232721000206	Putative transposase; Region: Y2_Tnp; pfam04986
232721000207	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
232721000208	Putative transposase; Region: Y2_Tnp; pfam04986
232721000209	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
232721000210	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
232721000211	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
232721000212	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
232721000213	Putative transposase; Region: Y2_Tnp; pfam04986
232721000214	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
232721000215	classical (c) SDRs; Region: SDR_c; cd05233
232721000216	NAD(P) binding site [chemical binding]; other site
232721000217	active site
232721000218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
232721000219	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
232721000220	Antirestriction protein; Region: Antirestrict; pfam03230
232721000221	Protein of unknown function (DUF2761); Region: DUF2761; pfam10959
232721000222	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721000223	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
232721000224	P-loop; other site
232721000225	Magnesium ion binding site [ion binding]; other site
232721000226	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721000227	Magnesium ion binding site [ion binding]; other site
232721000228	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
232721000229	ParB-like nuclease domain; Region: ParB; smart00470
232721000230	KorB domain; Region: KorB; pfam08535
232721000231	KorB C-terminal beta-barrel domain; Region: KorB_C; pfam06613
232721000232	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
232721000233	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
232721000234	conjugal transfer protein TraM; Provisional; Region: PRK13895
232721000235	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
232721000236	P-loop; other site
232721000237	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
232721000238	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
232721000239	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
232721000240	entry exclusion lipoprotein TrbK; Region: TrbK_RP4; TIGR04359
232721000241	conjugal transfer coupling protein TraG; Provisional; Region: PRK13880
232721000242	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
232721000243	Walker A motif; other site
232721000244	ATP binding site [chemical binding]; other site
232721000245	Walker B motif; other site
232721000246	conjugal transfer peptidase TraF; Provisional; Region: PRK13884
232721000247	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
232721000248	DNA topoisomerase III; Provisional; Region: PRK07726
232721000249	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
232721000250	active site
232721000251	putative interdomain interaction site [polypeptide binding]; other site
232721000252	putative metal-binding site [ion binding]; other site
232721000253	putative nucleotide binding site [chemical binding]; other site
232721000254	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
232721000255	domain I; other site
232721000256	DNA binding groove [nucleotide binding]
232721000257	phosphate binding site [ion binding]; other site
232721000258	domain II; other site
232721000259	domain III; other site
232721000260	nucleotide binding site [chemical binding]; other site
232721000261	catalytic site [active]
232721000262	domain IV; other site
232721000263	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
232721000264	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
232721000265	NlpC/P60 family; Region: NLPC_P60; pfam00877
232721000266	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
232721000267	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
232721000268	PAS domain S-box; Region: sensory_box; TIGR00229
232721000269	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721000270	putative active site [active]
232721000271	heme pocket [chemical binding]; other site
232721000272	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721000273	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721000274	metal binding site [ion binding]; metal-binding site
232721000275	active site
232721000276	I-site; other site
232721000277	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
232721000278	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
232721000279	Transcriptional regulator [Transcription]; Region: IclR; COG1414
232721000280	Bacterial transcriptional regulator; Region: IclR; pfam01614
232721000281	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000282	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
232721000283	LTXXQ motif family protein; Region: LTXXQ; pfam07813
232721000284	recombination associated protein; Reviewed; Region: rdgC; PRK00321
232721000285	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
232721000286	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
232721000287	PAS domain; Region: PAS; smart00091
232721000288	PAS fold; Region: PAS_7; pfam12860
232721000289	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
232721000290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721000291	dimer interface [polypeptide binding]; other site
232721000292	phosphorylation site [posttranslational modification]
232721000293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721000294	ATP binding site [chemical binding]; other site
232721000295	Mg2+ binding site [ion binding]; other site
232721000296	G-X-G motif; other site
232721000297	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721000298	Response regulator receiver domain; Region: Response_reg; pfam00072
232721000299	active site
232721000300	phosphorylation site [posttranslational modification]
232721000301	intermolecular recognition site; other site
232721000302	dimerization interface [polypeptide binding]; other site
232721000303	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
232721000304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721000305	active site
232721000306	phosphorylation site [posttranslational modification]
232721000307	intermolecular recognition site; other site
232721000308	dimerization interface [polypeptide binding]; other site
232721000309	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
232721000310	DNA binding residues [nucleotide binding]
232721000311	dimerization interface [polypeptide binding]; other site
232721000312	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
232721000313	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
232721000314	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
232721000315	beta-ketothiolase; Provisional; Region: PRK09051
232721000316	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721000317	dimer interface [polypeptide binding]; other site
232721000318	active site
232721000319	Protein of unknown function, DUF488; Region: DUF488; pfam04343
232721000320	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
232721000321	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
232721000322	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
232721000323	DNA binding residues [nucleotide binding]
232721000324	dimer interface [polypeptide binding]; other site
232721000325	copper binding site [ion binding]; other site
232721000326	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721000327	metal-binding site [ion binding]
232721000328	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
232721000329	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721000330	metal-binding site [ion binding]
232721000331	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721000332	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721000333	motif II; other site
232721000334	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721000335	dimerization interface [polypeptide binding]; other site
232721000336	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721000337	dimer interface [polypeptide binding]; other site
232721000338	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
232721000339	putative CheW interface [polypeptide binding]; other site
232721000340	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
232721000341	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
232721000342	FMN binding site [chemical binding]; other site
232721000343	active site
232721000344	substrate binding site [chemical binding]; other site
232721000345	catalytic residue [active]
232721000346	glutathionine S-transferase; Provisional; Region: PRK10542
232721000347	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
232721000348	C-terminal domain interface [polypeptide binding]; other site
232721000349	GSH binding site (G-site) [chemical binding]; other site
232721000350	dimer interface [polypeptide binding]; other site
232721000351	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
232721000352	dimer interface [polypeptide binding]; other site
232721000353	N-terminal domain interface [polypeptide binding]; other site
232721000354	substrate binding pocket (H-site) [chemical binding]; other site
232721000355	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
232721000356	Predicted flavoprotein [General function prediction only]; Region: COG0431
232721000357	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
232721000358	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
232721000359	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
232721000360	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
232721000361	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
232721000362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721000363	S-adenosylmethionine binding site [chemical binding]; other site
232721000364	LysE type translocator; Region: LysE; cl00565
232721000365	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
232721000366	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721000367	P-loop; other site
232721000368	Magnesium ion binding site [ion binding]; other site
232721000369	Serine hydrolase; Region: Ser_hydrolase; pfam06821
232721000370	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
232721000371	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
232721000372	ParB-like nuclease domain; Region: ParB; smart00470
232721000373	Methyltransferase domain; Region: Methyltransf_12; pfam08242
232721000374	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
232721000375	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
232721000376	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
232721000377	sulfite oxidase; Provisional; Region: PLN00177
232721000378	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
232721000379	Moco binding site; other site
232721000380	metal coordination site [ion binding]; other site
232721000381	dimerization interface [polypeptide binding]; other site
232721000382	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
232721000383	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
232721000384	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
232721000385	DNA binding residues [nucleotide binding]
232721000386	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
232721000387	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
232721000388	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
232721000389	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
232721000390	FAD binding domain; Region: FAD_binding_4; pfam01565
232721000391	Homeodomain-like domain; Region: HTH_23; pfam13384
232721000392	Winged helix-turn helix; Region: HTH_29; pfam13551
232721000393	Homeodomain-like domain; Region: HTH_32; pfam13565
232721000394	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721000395	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721000396	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
232721000397	EF-hand domain pair; Region: EF_hand_5; pfam13499
232721000398	Ca2+ binding site [ion binding]; other site
232721000399	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
232721000400	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
232721000401	CoenzymeA binding site [chemical binding]; other site
232721000402	subunit interaction site [polypeptide binding]; other site
232721000403	PHB binding site; other site
232721000404	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
232721000405	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
232721000406	putative ligand binding site [chemical binding]; other site
232721000407	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
232721000408	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
232721000409	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
232721000410	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
232721000411	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
232721000412	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721000413	PAS domain; Region: PAS_9; pfam13426
232721000414	putative active site [active]
232721000415	heme pocket [chemical binding]; other site
232721000416	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721000417	PAS domain; Region: PAS_9; pfam13426
232721000418	putative active site [active]
232721000419	heme pocket [chemical binding]; other site
232721000420	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721000421	dimer interface [polypeptide binding]; other site
232721000422	putative CheW interface [polypeptide binding]; other site
232721000423	B12 binding domain; Region: B12-binding; pfam02310
232721000424	B12 binding site [chemical binding]; other site
232721000425	Radical SAM superfamily; Region: Radical_SAM; pfam04055
232721000426	hypothetical protein; Provisional; Region: PRK09126
232721000427	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
232721000428	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
232721000429	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721000430	acyl-activating enzyme (AAE) consensus motif; other site
232721000431	AMP binding site [chemical binding]; other site
232721000432	active site
232721000433	CoA binding site [chemical binding]; other site
232721000434	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721000435	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721000436	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
232721000437	dimerization interface [polypeptide binding]; other site
232721000438	substrate binding pocket [chemical binding]; other site
232721000439	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000440	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
232721000441	CoA-transferase family III; Region: CoA_transf_3; pfam02515
232721000442	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
232721000443	CoA-transferase family III; Region: CoA_transf_3; pfam02515
232721000444	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
232721000445	active site
232721000446	catalytic site [active]
232721000447	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000448	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721000449	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721000450	active site
232721000451	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
232721000452	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721000453	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721000454	enoyl-CoA hydratase; Provisional; Region: PRK09245
232721000455	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721000456	substrate binding site [chemical binding]; other site
232721000457	oxyanion hole (OAH) forming residues; other site
232721000458	trimer interface [polypeptide binding]; other site
232721000459	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
232721000460	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
232721000461	septum formation inhibitor; Reviewed; Region: PRK01973
232721000462	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
232721000463	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
232721000464	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
232721000465	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
232721000466	Switch I; other site
232721000467	Switch II; other site
232721000468	cell division topological specificity factor MinE; Provisional; Region: PRK13989
232721000469	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
232721000470	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
232721000471	TAP-like protein; Region: Abhydrolase_4; pfam08386
232721000472	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
232721000473	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
232721000474	putative ligand binding site [chemical binding]; other site
232721000475	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
232721000476	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
232721000477	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
232721000478	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721000479	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721000480	dimerization interface [polypeptide binding]; other site
232721000481	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
232721000482	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721000483	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
232721000484	Ligand Binding Site [chemical binding]; other site
232721000485	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
232721000486	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
232721000487	active site
232721000488	metal binding site [ion binding]; metal-binding site
232721000489	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721000490	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721000491	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
232721000492	substrate binding pocket [chemical binding]; other site
232721000493	dimerization interface [polypeptide binding]; other site
232721000494	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
232721000495	active site
232721000496	substrate-binding site [chemical binding]; other site
232721000497	metal-binding site [ion binding]
232721000498	GTP binding site [chemical binding]; other site
232721000499	threonine dehydratase; Provisional; Region: PRK07334
232721000500	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
232721000501	tetramer interface [polypeptide binding]; other site
232721000502	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721000503	catalytic residue [active]
232721000504	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
232721000505	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721000506	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721000507	active site
232721000508	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
232721000509	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
232721000510	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
232721000511	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721000512	ATP binding site [chemical binding]; other site
232721000513	putative Mg++ binding site [ion binding]; other site
232721000514	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721000515	nucleotide binding region [chemical binding]; other site
232721000516	ATP-binding site [chemical binding]; other site
232721000517	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
232721000518	HRDC domain; Region: HRDC; pfam00570
232721000519	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
232721000520	FeS/SAM binding site; other site
232721000521	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
232721000522	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
232721000523	ATP cone domain; Region: ATP-cone; pfam03477
232721000524	Class III ribonucleotide reductase; Region: RNR_III; cd01675
232721000525	effector binding site; other site
232721000526	active site
232721000527	Zn binding site [ion binding]; other site
232721000528	PAS fold; Region: PAS_4; pfam08448
232721000529	GAF domain; Region: GAF_2; pfam13185
232721000530	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721000531	PAS domain; Region: PAS_9; pfam13426
232721000532	putative active site [active]
232721000533	heme pocket [chemical binding]; other site
232721000534	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721000535	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721000536	metal binding site [ion binding]; metal-binding site
232721000537	active site
232721000538	I-site; other site
232721000539	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
232721000540	Transposase domain (DUF772); Region: DUF772; pfam05598
232721000541	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721000542	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721000543	Homeodomain-like domain; Region: HTH_23; pfam13384
232721000544	Winged helix-turn helix; Region: HTH_29; pfam13551
232721000545	Homeodomain-like domain; Region: HTH_32; pfam13565
232721000546	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721000547	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721000548	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
232721000549	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
232721000550	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
232721000551	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
232721000552	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721000553	Walker A motif; other site
232721000554	ATP binding site [chemical binding]; other site
232721000555	Walker B motif; other site
232721000556	arginine finger; other site
232721000557	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
232721000558	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
232721000559	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
232721000560	aspartate aminotransferase; Provisional; Region: PRK06108
232721000561	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721000562	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721000563	homodimer interface [polypeptide binding]; other site
232721000564	catalytic residue [active]
232721000565	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000566	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
232721000567	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721000568	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
232721000569	acyl-activating enzyme (AAE) consensus motif; other site
232721000570	acyl-activating enzyme (AAE) consensus motif; other site
232721000571	putative AMP binding site [chemical binding]; other site
232721000572	putative active site [active]
232721000573	putative CoA binding site [chemical binding]; other site
232721000574	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000575	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
232721000576	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
232721000577	CoenzymeA binding site [chemical binding]; other site
232721000578	subunit interaction site [polypeptide binding]; other site
232721000579	PHB binding site; other site
232721000580	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000581	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000582	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721000583	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721000584	active site
232721000585	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721000586	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
232721000587	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
232721000588	acyl-activating enzyme (AAE) consensus motif; other site
232721000589	acyl-activating enzyme (AAE) consensus motif; other site
232721000590	putative active site [active]
232721000591	putative AMP binding site [chemical binding]; other site
232721000592	putative CoA binding site [chemical binding]; other site
232721000593	CoA binding site [chemical binding]; other site
232721000594	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721000595	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
232721000596	dimer interface [polypeptide binding]; other site
232721000597	active site
232721000598	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
232721000599	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721000600	NAD(P) binding site [chemical binding]; other site
232721000601	active site
232721000602	enoyl-CoA hydratase; Provisional; Region: PRK08252
232721000603	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721000604	substrate binding site [chemical binding]; other site
232721000605	oxyanion hole (OAH) forming residues; other site
232721000606	trimer interface [polypeptide binding]; other site
232721000607	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000608	short chain dehydrogenase; Provisional; Region: PRK07576
232721000609	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
232721000610	NAD(P) binding site [chemical binding]; other site
232721000611	substrate binding site [chemical binding]; other site
232721000612	homotetramer interface [polypeptide binding]; other site
232721000613	active site
232721000614	homodimer interface [polypeptide binding]; other site
232721000615	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
232721000616	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721000617	substrate binding site [chemical binding]; other site
232721000618	oxyanion hole (OAH) forming residues; other site
232721000619	trimer interface [polypeptide binding]; other site
232721000620	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
232721000621	Transcriptional regulator [Transcription]; Region: IclR; COG1414
232721000622	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
232721000623	CoA-transferase family III; Region: CoA_transf_3; pfam02515
232721000624	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721000625	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
232721000626	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000627	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
232721000628	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
232721000629	CoA-transferase family III; Region: CoA_transf_3; pfam02515
232721000630	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721000631	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
232721000632	active site
232721000633	Uncharacterized conserved protein [Function unknown]; Region: COG3777
232721000634	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
232721000635	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
232721000636	active site 2 [active]
232721000637	active site 1 [active]
232721000638	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
232721000639	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721000640	NAD(P) binding site [chemical binding]; other site
232721000641	active site
232721000642	enoyl-CoA hydratase; Region: PLN02864
232721000643	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
232721000644	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
232721000645	dimer interaction site [polypeptide binding]; other site
232721000646	substrate-binding tunnel; other site
232721000647	active site
232721000648	catalytic site [active]
232721000649	substrate binding site [chemical binding]; other site
232721000650	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
232721000651	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721000652	substrate binding site [chemical binding]; other site
232721000653	oxyanion hole (OAH) forming residues; other site
232721000654	trimer interface [polypeptide binding]; other site
232721000655	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
232721000656	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
232721000657	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
232721000658	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
232721000659	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
232721000660	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721000661	dimer interface [polypeptide binding]; other site
232721000662	active site
232721000663	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000664	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
232721000665	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721000666	acyl-activating enzyme (AAE) consensus motif; other site
232721000667	AMP binding site [chemical binding]; other site
232721000668	active site
232721000669	CoA binding site [chemical binding]; other site
232721000670	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000671	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
232721000672	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
232721000673	DUF35 OB-fold domain; Region: DUF35; pfam01796
232721000674	thiolase; Provisional; Region: PRK06158
232721000675	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
232721000676	active site
232721000677	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721000678	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721000679	active site
232721000680	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
232721000681	CoenzymeA binding site [chemical binding]; other site
232721000682	subunit interaction site [polypeptide binding]; other site
232721000683	PHB binding site; other site
232721000684	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721000685	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721000686	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
232721000687	putative dimerization interface [polypeptide binding]; other site
232721000688	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
232721000689	CoA-transferase family III; Region: CoA_transf_3; pfam02515
232721000690	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
232721000691	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
232721000692	trimer interface [polypeptide binding]; other site
232721000693	eyelet of channel; other site
232721000694	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
232721000695	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
232721000696	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
232721000697	NAD(P) binding site [chemical binding]; other site
232721000698	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
232721000699	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721000700	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721000701	LysR substrate binding domain; Region: LysR_substrate; pfam03466
232721000702	dimerization interface [polypeptide binding]; other site
232721000703	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
232721000704	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
232721000705	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
232721000706	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721000707	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
232721000708	dimerization interface [polypeptide binding]; other site
232721000709	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
232721000710	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
232721000711	octamer interface [polypeptide binding]; other site
232721000712	active site
232721000713	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
232721000714	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
232721000715	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
232721000716	dimer interface [polypeptide binding]; other site
232721000717	active site
232721000718	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000719	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
232721000720	4Fe-4S binding domain; Region: Fer4_5; pfam12801
232721000721	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
232721000722	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
232721000723	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
232721000724	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
232721000725	[2Fe-2S] cluster binding site [ion binding]; other site
232721000726	PAS domain; Region: PAS_9; pfam13426
232721000727	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721000728	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
232721000729	Walker A motif; other site
232721000730	ATP binding site [chemical binding]; other site
232721000731	Walker B motif; other site
232721000732	arginine finger; other site
232721000733	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
232721000734	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
232721000735	substrate binding pocket [chemical binding]; other site
232721000736	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
232721000737	B12 binding site [chemical binding]; other site
232721000738	cobalt ligand [ion binding]; other site
232721000739	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
232721000740	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
232721000741	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
232721000742	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
232721000743	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
232721000744	Peptidase M15; Region: Peptidase_M15_3; cl01194
232721000745	shikimate kinase; Reviewed; Region: aroK; PRK00131
232721000746	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
232721000747	ADP binding site [chemical binding]; other site
232721000748	magnesium binding site [ion binding]; other site
232721000749	putative shikimate binding site; other site
232721000750	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
232721000751	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
232721000752	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
232721000753	FAD binding pocket [chemical binding]; other site
232721000754	FAD binding motif [chemical binding]; other site
232721000755	phosphate binding motif [ion binding]; other site
232721000756	beta-alpha-beta structure motif; other site
232721000757	NAD binding pocket [chemical binding]; other site
232721000758	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
232721000759	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
232721000760	putative ligand binding site [chemical binding]; other site
232721000761	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
232721000762	TM-ABC transporter signature motif; other site
232721000763	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
232721000764	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
232721000765	TM-ABC transporter signature motif; other site
232721000766	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
232721000767	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
232721000768	Walker A/P-loop; other site
232721000769	ATP binding site [chemical binding]; other site
232721000770	Q-loop/lid; other site
232721000771	ABC transporter signature motif; other site
232721000772	Walker B; other site
232721000773	D-loop; other site
232721000774	H-loop/switch region; other site
232721000775	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
232721000776	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
232721000777	Walker A/P-loop; other site
232721000778	ATP binding site [chemical binding]; other site
232721000779	Q-loop/lid; other site
232721000780	ABC transporter signature motif; other site
232721000781	Walker B; other site
232721000782	D-loop; other site
232721000783	H-loop/switch region; other site
232721000784	transcriptional regulator; Provisional; Region: PRK10632
232721000785	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721000786	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
232721000787	putative effector binding pocket; other site
232721000788	putative dimerization interface [polypeptide binding]; other site
232721000789	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721000790	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
232721000791	NAD(P) binding site [chemical binding]; other site
232721000792	active site
232721000793	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
232721000794	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
232721000795	dimerization interface [polypeptide binding]; other site
232721000796	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721000797	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721000798	dimer interface [polypeptide binding]; other site
232721000799	putative CheW interface [polypeptide binding]; other site
232721000800	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
232721000801	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
232721000802	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
232721000803	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
232721000804	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
232721000805	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
232721000806	Nitrogen regulatory protein P-II; Region: P-II; smart00938
232721000807	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
232721000808	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
232721000809	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
232721000810	FAD binding domain; Region: FAD_binding_4; pfam01565
232721000811	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
232721000812	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
232721000813	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
232721000814	Cysteine-rich domain; Region: CCG; pfam02754
232721000815	Cysteine-rich domain; Region: CCG; pfam02754
232721000816	ProQ/FINO family; Region: ProQ; smart00945
232721000817	putative RNA binding sites [nucleotide binding]; other site
232721000818	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
232721000819	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
232721000820	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
232721000821	Predicted transcriptional regulator [Transcription]; Region: COG2378
232721000822	HTH domain; Region: HTH_11; pfam08279
232721000823	WYL domain; Region: WYL; pfam13280
232721000824	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
232721000825	catalytic residues [active]
232721000826	dimer interface [polypeptide binding]; other site
232721000827	EamA-like transporter family; Region: EamA; pfam00892
232721000828	lysophospholipid transporter LplT; Provisional; Region: PRK11195
232721000829	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721000830	Protein of unknown function (DUF575); Region: DUF575; pfam04746
232721000831	alanine racemase; Reviewed; Region: dadX; PRK03646
232721000832	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
232721000833	active site
232721000834	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
232721000835	substrate binding site [chemical binding]; other site
232721000836	catalytic residues [active]
232721000837	dimer interface [polypeptide binding]; other site
232721000838	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
232721000839	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
232721000840	C-terminal domain interface [polypeptide binding]; other site
232721000841	GSH binding site (G-site) [chemical binding]; other site
232721000842	dimer interface [polypeptide binding]; other site
232721000843	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
232721000844	dimer interface [polypeptide binding]; other site
232721000845	N-terminal domain interface [polypeptide binding]; other site
232721000846	substrate binding pocket (H-site) [chemical binding]; other site
232721000847	DNA repair protein RadA; Provisional; Region: PRK11823
232721000848	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
232721000849	Walker A motif/ATP binding site; other site
232721000850	ATP binding site [chemical binding]; other site
232721000851	Walker B motif; other site
232721000852	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
232721000853	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
232721000854	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
232721000855	homodimer interface [polypeptide binding]; other site
232721000856	substrate-cofactor binding pocket; other site
232721000857	catalytic residue [active]
232721000858	Zinc-finger domain; Region: zf-CHCC; cl01821
232721000859	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
232721000860	O-Antigen ligase; Region: Wzy_C; pfam04932
232721000861	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721000862	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
232721000863	putative ADP-binding pocket [chemical binding]; other site
232721000864	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
232721000865	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
232721000866	active site
232721000867	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
232721000868	Nitronate monooxygenase; Region: NMO; pfam03060
232721000869	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
232721000870	FMN binding site [chemical binding]; other site
232721000871	substrate binding site [chemical binding]; other site
232721000872	putative catalytic residue [active]
232721000873	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721000874	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
232721000875	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721000876	dimerization interface [polypeptide binding]; other site
232721000877	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
232721000878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
232721000879	MOSC domain; Region: MOSC; pfam03473
232721000880	3-alpha domain; Region: 3-alpha; pfam03475
232721000881	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
232721000882	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
232721000883	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721000884	dimer interface [polypeptide binding]; other site
232721000885	phosphorylation site [posttranslational modification]
232721000886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721000887	ATP binding site [chemical binding]; other site
232721000888	Mg2+ binding site [ion binding]; other site
232721000889	G-X-G motif; other site
232721000890	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
232721000891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721000892	active site
232721000893	phosphorylation site [posttranslational modification]
232721000894	intermolecular recognition site; other site
232721000895	dimerization interface [polypeptide binding]; other site
232721000896	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721000897	DNA binding site [nucleotide binding]
232721000898	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
232721000899	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
232721000900	BRO family, N-terminal domain; Region: Bro-N; pfam02498
232721000901	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
232721000902	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
232721000903	AmpG-like permease; Region: 2A0125; TIGR00901
232721000904	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
232721000905	Peptidase family M48; Region: Peptidase_M48; pfam01435
232721000906	Transcriptional regulators [Transcription]; Region: GntR; COG1802
232721000907	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
232721000908	DNA-binding site [nucleotide binding]; DNA binding site
232721000909	FCD domain; Region: FCD; pfam07729
232721000910	Activator of aromatic catabolism; Region: XylR_N; pfam06505
232721000911	V4R domain; Region: V4R; pfam02830
232721000912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721000913	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
232721000914	Walker A motif; other site
232721000915	ATP binding site [chemical binding]; other site
232721000916	Walker B motif; other site
232721000917	arginine finger; other site
232721000918	Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099
232721000919	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
232721000920	dimerization interface [polypeptide binding]; other site
232721000921	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
232721000922	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
232721000923	dimerization interface [polypeptide binding]; other site
232721000924	putative path to active site cavity [active]
232721000925	diiron center [ion binding]; other site
232721000926	Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663
232721000927	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
232721000928	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
232721000929	catalytic loop [active]
232721000930	iron binding site [ion binding]; other site
232721000931	Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211
232721000932	FAD binding pocket [chemical binding]; other site
232721000933	FAD binding motif [chemical binding]; other site
232721000934	phosphate binding motif [ion binding]; other site
232721000935	beta-alpha-beta structure motif; other site
232721000936	NAD binding pocket [chemical binding]; other site
232721000937	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
232721000938	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721000939	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446
232721000940	dimerization interface [polypeptide binding]; other site
232721000941	putative substrate binding pocket [chemical binding]; other site
232721000942	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
232721000943	catalytic loop [active]
232721000944	iron binding site [ion binding]; other site
232721000945	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
232721000946	N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265
232721000947	tetramer interface [polypeptide binding]; other site
232721000948	C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243
232721000949	tetramer interface [polypeptide binding]; other site
232721000950	active site
232721000951	Fe binding site [ion binding]; other site
232721000952	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
232721000953	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721000954	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446
232721000955	dimerization interface [polypeptide binding]; other site
232721000956	putative substrate binding pocket [chemical binding]; other site
232721000957	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
232721000958	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
232721000959	catalytic loop [active]
232721000960	iron binding site [ion binding]; other site
232721000961	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
232721000962	N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265
232721000963	tetramer interface [polypeptide binding]; other site
232721000964	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
232721000965	active site
232721000966	metal binding site [ion binding]; metal-binding site
232721000967	Domain of unknown function (DUF336); Region: DUF336; pfam03928
232721000968	2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216
232721000969	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
232721000970	NAD binding site [chemical binding]; other site
232721000971	catalytic residues [active]
232721000972	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
232721000973	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
232721000974	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
232721000975	acetaldehyde dehydrogenase; Validated; Region: PRK08300
232721000976	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
232721000977	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
232721000978	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
232721000979	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
232721000980	active site
232721000981	catalytic residues [active]
232721000982	metal binding site [ion binding]; metal-binding site
232721000983	DmpG-like communication domain; Region: DmpG_comm; pfam07836
232721000984	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
232721000985	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721000986	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
232721000987	active site 1 [active]
232721000988	dimer interface [polypeptide binding]; other site
232721000989	hexamer interface [polypeptide binding]; other site
232721000990	active site 2 [active]
232721000991	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
232721000992	Transcriptional regulators [Transcription]; Region: GntR; COG1802
232721000993	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
232721000994	DNA-binding site [nucleotide binding]; DNA binding site
232721000995	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721000996	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721000997	active site
232721000998	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
232721000999	classical (c) SDRs; Region: SDR_c; cd05233
232721001000	NAD(P) binding site [chemical binding]; other site
232721001001	active site
232721001002	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
232721001003	putative active site [active]
232721001004	putative substrate binding site [chemical binding]; other site
232721001005	ATP binding site [chemical binding]; other site
232721001006	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
232721001007	putative active site [active]
232721001008	putative catalytic site [active]
232721001009	putative DNA binding site [nucleotide binding]; other site
232721001010	putative phosphate binding site [ion binding]; other site
232721001011	metal binding site A [ion binding]; metal-binding site
232721001012	putative AP binding site [nucleotide binding]; other site
232721001013	putative metal binding site B [ion binding]; other site
232721001014	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
232721001015	active site
232721001016	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
232721001017	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
232721001018	GatB domain; Region: GatB_Yqey; smart00845
232721001019	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
232721001020	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
232721001021	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
232721001022	rod shape-determining protein MreB; Provisional; Region: PRK13927
232721001023	MreB and similar proteins; Region: MreB_like; cd10225
232721001024	nucleotide binding site [chemical binding]; other site
232721001025	Mg binding site [ion binding]; other site
232721001026	putative protofilament interaction site [polypeptide binding]; other site
232721001027	RodZ interaction site [polypeptide binding]; other site
232721001028	rod shape-determining protein MreC; Provisional; Region: PRK13922
232721001029	rod shape-determining protein MreC; Region: MreC; pfam04085
232721001030	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
232721001031	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
232721001032	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
232721001033	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
232721001034	EamA-like transporter family; Region: EamA; pfam00892
232721001035	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
232721001036	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
232721001037	Walker A/P-loop; other site
232721001038	ATP binding site [chemical binding]; other site
232721001039	Q-loop/lid; other site
232721001040	ABC transporter signature motif; other site
232721001041	Walker B; other site
232721001042	D-loop; other site
232721001043	H-loop/switch region; other site
232721001044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721001045	dimer interface [polypeptide binding]; other site
232721001046	conserved gate region; other site
232721001047	putative PBP binding loops; other site
232721001048	ABC-ATPase subunit interface; other site
232721001049	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
232721001050	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
232721001051	substrate binding pocket [chemical binding]; other site
232721001052	membrane-bound complex binding site; other site
232721001053	hinge residues; other site
232721001054	Arginase family; Region: Arginase; cd09989
232721001055	agmatinase; Region: agmatinase; TIGR01230
232721001056	active site
232721001057	Mn binding site [ion binding]; other site
232721001058	oligomer interface [polypeptide binding]; other site
232721001059	hypothetical protein; Provisional; Region: PRK10621
232721001060	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
232721001061	choline dehydrogenase; Validated; Region: PRK02106
232721001062	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
232721001063	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
232721001064	Permease; Region: Permease; pfam02405
232721001065	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
232721001066	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
232721001067	Walker A/P-loop; other site
232721001068	ATP binding site [chemical binding]; other site
232721001069	Q-loop/lid; other site
232721001070	ABC transporter signature motif; other site
232721001071	Walker B; other site
232721001072	D-loop; other site
232721001073	H-loop/switch region; other site
232721001074	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
232721001075	mce related protein; Region: MCE; pfam02470
232721001076	hypothetical protein; Provisional; Region: PRK10428
232721001077	Hemerythrin; Region: Hemerythrin; cd12107
232721001078	Fe binding site [ion binding]; other site
232721001079	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721001080	PAS fold; Region: PAS_3; pfam08447
232721001081	putative active site [active]
232721001082	heme pocket [chemical binding]; other site
232721001083	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721001084	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721001085	metal binding site [ion binding]; metal-binding site
232721001086	active site
232721001087	I-site; other site
232721001088	MarC family integral membrane protein; Region: MarC; cl00919
232721001089	short chain dehydrogenase; Provisional; Region: PRK06123
232721001090	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721001091	NAD(P) binding site [chemical binding]; other site
232721001092	active site
232721001093	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
232721001094	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
232721001095	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
232721001096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721001097	putative substrate translocation pore; other site
232721001098	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721001099	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
232721001100	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
232721001101	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
232721001102	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
232721001103	MarR family; Region: MarR_2; cl17246
232721001104	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
232721001105	oligomer interface [polypeptide binding]; other site
232721001106	metal binding site [ion binding]; metal-binding site
232721001107	metal binding site [ion binding]; metal-binding site
232721001108	putative Cl binding site [ion binding]; other site
232721001109	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
232721001110	aspartate ring; other site
232721001111	basic sphincter; other site
232721001112	hydrophobic gate; other site
232721001113	periplasmic entrance; other site
232721001114	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
232721001115	dimer interface [polypeptide binding]; other site
232721001116	allosteric magnesium binding site [ion binding]; other site
232721001117	active site
232721001118	aspartate-rich active site metal binding site; other site
232721001119	Schiff base residues; other site
232721001120	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
232721001121	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
232721001122	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
232721001123	dimer interface [polypeptide binding]; other site
232721001124	[2Fe-2S] cluster binding site [ion binding]; other site
232721001125	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
232721001126	Serine hydrolase; Region: Ser_hydrolase; cl17834
232721001127	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
232721001128	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
232721001129	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
232721001130	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
232721001131	S17 interaction site [polypeptide binding]; other site
232721001132	S8 interaction site; other site
232721001133	16S rRNA interaction site [nucleotide binding]; other site
232721001134	streptomycin interaction site [chemical binding]; other site
232721001135	23S rRNA interaction site [nucleotide binding]; other site
232721001136	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
232721001137	30S ribosomal protein S7; Validated; Region: PRK05302
232721001138	elongation factor G; Reviewed; Region: PRK00007
232721001139	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
232721001140	G1 box; other site
232721001141	putative GEF interaction site [polypeptide binding]; other site
232721001142	GTP/Mg2+ binding site [chemical binding]; other site
232721001143	Switch I region; other site
232721001144	G2 box; other site
232721001145	G3 box; other site
232721001146	Switch II region; other site
232721001147	G4 box; other site
232721001148	G5 box; other site
232721001149	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
232721001150	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
232721001151	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
232721001152	elongation factor Tu; Reviewed; Region: PRK00049
232721001153	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
232721001154	G1 box; other site
232721001155	GEF interaction site [polypeptide binding]; other site
232721001156	GTP/Mg2+ binding site [chemical binding]; other site
232721001157	Switch I region; other site
232721001158	G2 box; other site
232721001159	G3 box; other site
232721001160	Switch II region; other site
232721001161	G4 box; other site
232721001162	G5 box; other site
232721001163	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
232721001164	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
232721001165	Antibiotic Binding Site [chemical binding]; other site
232721001166	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
232721001167	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
232721001168	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
232721001169	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
232721001170	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
232721001171	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
232721001172	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
232721001173	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
232721001174	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
232721001175	putative translocon binding site; other site
232721001176	protein-rRNA interface [nucleotide binding]; other site
232721001177	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
232721001178	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
232721001179	G-X-X-G motif; other site
232721001180	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
232721001181	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
232721001182	23S rRNA interface [nucleotide binding]; other site
232721001183	5S rRNA interface [nucleotide binding]; other site
232721001184	putative antibiotic binding site [chemical binding]; other site
232721001185	L25 interface [polypeptide binding]; other site
232721001186	L27 interface [polypeptide binding]; other site
232721001187	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
232721001188	23S rRNA interface [nucleotide binding]; other site
232721001189	putative translocon interaction site; other site
232721001190	signal recognition particle (SRP54) interaction site; other site
232721001191	L23 interface [polypeptide binding]; other site
232721001192	trigger factor interaction site; other site
232721001193	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
232721001194	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
232721001195	catalytic triad [active]
232721001196	dimer interface [polypeptide binding]; other site
232721001197	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
232721001198	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
232721001199	Coenzyme A binding pocket [chemical binding]; other site
232721001200	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
232721001201	Cytochrome C' Region: Cytochrom_C_2; pfam01322
232721001202	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
232721001203	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
232721001204	catalytic residues [active]
232721001205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721001206	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721001207	putative substrate translocation pore; other site
232721001208	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
232721001209	active pocket/dimerization site; other site
232721001210	active site
232721001211	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
232721001212	dimerization domain swap beta strand [polypeptide binding]; other site
232721001213	regulatory protein interface [polypeptide binding]; other site
232721001214	active site
232721001215	regulatory phosphorylation site [posttranslational modification]; other site
232721001216	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
232721001217	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
232721001218	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
232721001219	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
232721001220	lipoyl synthase; Provisional; Region: PRK05481
232721001221	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
232721001222	FeS/SAM binding site; other site
232721001223	lipoate-protein ligase B; Provisional; Region: PRK14346
232721001224	Protein of unknown function (DUF493); Region: DUF493; cl01102
232721001225	ATP synthase I chain; Region: ATP_synt_I; pfam03899
232721001226	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
232721001227	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
232721001228	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
232721001229	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
232721001230	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
232721001231	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
232721001232	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
232721001233	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
232721001234	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
232721001235	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
232721001236	beta subunit interaction interface [polypeptide binding]; other site
232721001237	Walker A motif; other site
232721001238	ATP binding site [chemical binding]; other site
232721001239	Walker B motif; other site
232721001240	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
232721001241	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
232721001242	core domain interface [polypeptide binding]; other site
232721001243	delta subunit interface [polypeptide binding]; other site
232721001244	epsilon subunit interface [polypeptide binding]; other site
232721001245	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
232721001246	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
232721001247	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
232721001248	alpha subunit interaction interface [polypeptide binding]; other site
232721001249	Walker A motif; other site
232721001250	ATP binding site [chemical binding]; other site
232721001251	Walker B motif; other site
232721001252	inhibitor binding site; inhibition site
232721001253	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
232721001254	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
232721001255	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
232721001256	gamma subunit interface [polypeptide binding]; other site
232721001257	epsilon subunit interface [polypeptide binding]; other site
232721001258	LBP interface [polypeptide binding]; other site
232721001259	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
232721001260	ATP-dependent DNA ligase; Validated; Region: PRK09247
232721001261	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
232721001262	active site
232721001263	DNA binding site [nucleotide binding]
232721001264	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
232721001265	DNA binding site [nucleotide binding]
232721001266	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
232721001267	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721001268	ATP binding site [chemical binding]; other site
232721001269	putative Mg++ binding site [ion binding]; other site
232721001270	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721001271	nucleotide binding region [chemical binding]; other site
232721001272	ATP-binding site [chemical binding]; other site
232721001273	DEAD/H associated; Region: DEAD_assoc; pfam08494
232721001274	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
232721001275	putative active site [active]
232721001276	putative metal binding site [ion binding]; other site
232721001277	Repair protein; Region: Repair_PSII; pfam04536
232721001278	Repair protein; Region: Repair_PSII; pfam04536
232721001279	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
232721001280	SnoaL-like domain; Region: SnoaL_3; pfam13474
232721001281	SnoaL-like domain; Region: SnoaL_2; pfam12680
232721001282	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
232721001283	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
232721001284	Cytochrome c; Region: Cytochrom_C; cl11414
232721001285	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
232721001286	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
232721001287	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721001288	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
232721001289	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721001290	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
232721001291	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
232721001292	Transcriptional regulator [Transcription]; Region: IclR; COG1414
232721001293	Bacterial transcriptional regulator; Region: IclR; pfam01614
232721001294	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721001295	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721001296	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721001297	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
232721001298	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
232721001299	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721001300	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
232721001301	Protein export membrane protein; Region: SecD_SecF; cl14618
232721001302	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
232721001303	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
232721001304	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
232721001305	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
232721001306	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
232721001307	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
232721001308	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
232721001309	putative active site [active]
232721001310	putative dimer interface [polypeptide binding]; other site
232721001311	4-oxalocrotonate tautomerase; Provisional; Region: PRK00745
232721001312	active site 1 [active]
232721001313	dimer interface [polypeptide binding]; other site
232721001314	hexamer interface [polypeptide binding]; other site
232721001315	active site 2 [active]
232721001316	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
232721001317	malate synthase G; Provisional; Region: PRK02999
232721001318	active site
232721001319	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721001320	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721001321	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
232721001322	putative effector binding pocket; other site
232721001323	dimerization interface [polypeptide binding]; other site
232721001324	Protein of unknown function (DUF3016); Region: DUF3016; pfam11454
232721001325	Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980
232721001326	psiF repeat; Region: PsiF_repeat; pfam07769
232721001327	psiF repeat; Region: PsiF_repeat; pfam07769
232721001328	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
232721001329	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
232721001330	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
232721001331	active site
232721001332	HIGH motif; other site
232721001333	nucleotide binding site [chemical binding]; other site
232721001334	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
232721001335	KMSK motif region; other site
232721001336	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
232721001337	tRNA binding surface [nucleotide binding]; other site
232721001338	anticodon binding site; other site
232721001339	Sporulation related domain; Region: SPOR; pfam05036
232721001340	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
232721001341	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
232721001342	catalytic residues [active]
232721001343	hinge region; other site
232721001344	alpha helical domain; other site
232721001345	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
232721001346	OstA-like protein; Region: OstA; pfam03968
232721001347	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
232721001348	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
232721001349	Walker A/P-loop; other site
232721001350	ATP binding site [chemical binding]; other site
232721001351	Q-loop/lid; other site
232721001352	ABC transporter signature motif; other site
232721001353	Walker B; other site
232721001354	D-loop; other site
232721001355	H-loop/switch region; other site
232721001356	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
232721001357	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
232721001358	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
232721001359	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
232721001360	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
232721001361	active site
232721001362	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
232721001363	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
232721001364	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
232721001365	PIN domain; Region: PIN_3; pfam13470
232721001366	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
232721001367	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
232721001368	putative active site [active]
232721001369	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
232721001370	Competence-damaged protein; Region: CinA; pfam02464
232721001371	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
232721001372	tetramer interfaces [polypeptide binding]; other site
232721001373	binuclear metal-binding site [ion binding]; other site
232721001374	thiamine monophosphate kinase; Provisional; Region: PRK05731
232721001375	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
232721001376	ATP binding site [chemical binding]; other site
232721001377	dimerization interface [polypeptide binding]; other site
232721001378	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
232721001379	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
232721001380	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
232721001381	Site-specific recombinase; Region: SpecificRecomb; pfam10136
232721001382	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
232721001383	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
232721001384	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
232721001385	substrate binding site [chemical binding]; other site
232721001386	hexamer interface [polypeptide binding]; other site
232721001387	metal binding site [ion binding]; metal-binding site
232721001388	phosphoglycolate phosphatase; Provisional; Region: PRK13222
232721001389	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721001390	motif II; other site
232721001391	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
232721001392	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
232721001393	dimerization interface [polypeptide binding]; other site
232721001394	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721001395	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721001396	dimer interface [polypeptide binding]; other site
232721001397	putative CheW interface [polypeptide binding]; other site
232721001398	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
232721001399	anthranilate synthase component I; Provisional; Region: PRK13565
232721001400	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
232721001401	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
232721001402	Chorismate mutase type II; Region: CM_2; smart00830
232721001403	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
232721001404	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
232721001405	glutamine binding [chemical binding]; other site
232721001406	catalytic triad [active]
232721001407	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
232721001408	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
232721001409	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
232721001410	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
232721001411	active site
232721001412	ribulose/triose binding site [chemical binding]; other site
232721001413	phosphate binding site [ion binding]; other site
232721001414	substrate (anthranilate) binding pocket [chemical binding]; other site
232721001415	product (indole) binding pocket [chemical binding]; other site
232721001416	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721001417	PAS fold; Region: PAS_3; pfam08447
232721001418	putative active site [active]
232721001419	heme pocket [chemical binding]; other site
232721001420	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
232721001421	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721001422	putative active site [active]
232721001423	heme pocket [chemical binding]; other site
232721001424	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721001425	putative active site [active]
232721001426	heme pocket [chemical binding]; other site
232721001427	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721001428	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721001429	metal binding site [ion binding]; metal-binding site
232721001430	active site
232721001431	I-site; other site
232721001432	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
232721001433	ligand binding site [chemical binding]; other site
232721001434	active site
232721001435	UGI interface [polypeptide binding]; other site
232721001436	catalytic site [active]
232721001437	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
232721001438	EamA-like transporter family; Region: EamA; pfam00892
232721001439	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
232721001440	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
232721001441	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
232721001442	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
232721001443	generic binding surface II; other site
232721001444	ssDNA binding site; other site
232721001445	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721001446	ATP binding site [chemical binding]; other site
232721001447	putative Mg++ binding site [ion binding]; other site
232721001448	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721001449	nucleotide binding region [chemical binding]; other site
232721001450	ATP-binding site [chemical binding]; other site
232721001451	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
232721001452	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721001453	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
232721001454	dimerization interface [polypeptide binding]; other site
232721001455	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
232721001456	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
232721001457	dimerization interface [polypeptide binding]; other site
232721001458	DPS ferroxidase diiron center [ion binding]; other site
232721001459	ion pore; other site
232721001460	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
232721001461	putative active site; other site
232721001462	putative triphosphate binding site [ion binding]; other site
232721001463	CHAD domain; Region: CHAD; pfam05235
232721001464	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
232721001465	UbiA prenyltransferase family; Region: UbiA; pfam01040
232721001466	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
232721001467	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
232721001468	glycerol kinase; Provisional; Region: glpK; PRK00047
232721001469	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
232721001470	N- and C-terminal domain interface [polypeptide binding]; other site
232721001471	active site
232721001472	MgATP binding site [chemical binding]; other site
232721001473	catalytic site [active]
232721001474	metal binding site [ion binding]; metal-binding site
232721001475	glycerol binding site [chemical binding]; other site
232721001476	homotetramer interface [polypeptide binding]; other site
232721001477	homodimer interface [polypeptide binding]; other site
232721001478	FBP binding site [chemical binding]; other site
232721001479	protein IIAGlc interface [polypeptide binding]; other site
232721001480	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
232721001481	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
232721001482	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
232721001483	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
232721001484	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
232721001485	Walker A/P-loop; other site
232721001486	ATP binding site [chemical binding]; other site
232721001487	Q-loop/lid; other site
232721001488	ABC transporter signature motif; other site
232721001489	Walker B; other site
232721001490	D-loop; other site
232721001491	H-loop/switch region; other site
232721001492	TOBE domain; Region: TOBE_2; pfam08402
232721001493	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
232721001494	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
232721001495	Walker A/P-loop; other site
232721001496	ATP binding site [chemical binding]; other site
232721001497	Q-loop/lid; other site
232721001498	ABC transporter signature motif; other site
232721001499	Walker B; other site
232721001500	D-loop; other site
232721001501	H-loop/switch region; other site
232721001502	TOBE domain; Region: TOBE_2; pfam08402
232721001503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
232721001504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721001505	putative PBP binding loops; other site
232721001506	dimer interface [polypeptide binding]; other site
232721001507	ABC-ATPase subunit interface; other site
232721001508	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
232721001509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721001510	dimer interface [polypeptide binding]; other site
232721001511	conserved gate region; other site
232721001512	putative PBP binding loops; other site
232721001513	ABC-ATPase subunit interface; other site
232721001514	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
232721001515	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
232721001516	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
232721001517	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
232721001518	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
232721001519	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
232721001520	RNA binding site [nucleotide binding]; other site
232721001521	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
232721001522	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
232721001523	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
232721001524	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
232721001525	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
232721001526	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
232721001527	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
232721001528	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
232721001529	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
232721001530	5S rRNA interface [nucleotide binding]; other site
232721001531	23S rRNA interface [nucleotide binding]; other site
232721001532	L5 interface [polypeptide binding]; other site
232721001533	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
232721001534	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
232721001535	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
232721001536	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
232721001537	23S rRNA binding site [nucleotide binding]; other site
232721001538	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
232721001539	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
232721001540	SecY translocase; Region: SecY; pfam00344
232721001541	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
232721001542	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
232721001543	30S ribosomal protein S13; Region: bact_S13; TIGR03631
232721001544	30S ribosomal protein S11; Validated; Region: PRK05309
232721001545	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
232721001546	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
232721001547	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
232721001548	RNA binding surface [nucleotide binding]; other site
232721001549	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
232721001550	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
232721001551	alphaNTD homodimer interface [polypeptide binding]; other site
232721001552	alphaNTD - beta interaction site [polypeptide binding]; other site
232721001553	alphaNTD - beta' interaction site [polypeptide binding]; other site
232721001554	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
232721001555	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
232721001556	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
232721001557	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
232721001558	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
232721001559	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
232721001560	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
232721001561	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
232721001562	putative NAD(P) binding site [chemical binding]; other site
232721001563	active site
232721001564	putative substrate binding site [chemical binding]; other site
232721001565	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
232721001566	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
232721001567	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
232721001568	Ligand binding site; other site
232721001569	Putative Catalytic site; other site
232721001570	DXD motif; other site
232721001571	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
232721001572	Predicted methyltransferases [General function prediction only]; Region: COG0313
232721001573	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
232721001574	putative SAM binding site [chemical binding]; other site
232721001575	putative homodimer interface [polypeptide binding]; other site
232721001576	hypothetical protein; Provisional; Region: PRK14673
232721001577	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
232721001578	dimer interface [polypeptide binding]; other site
232721001579	active site
232721001580	outer membrane lipoprotein; Provisional; Region: PRK11023
232721001581	BON domain; Region: BON; pfam04972
232721001582	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
232721001583	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
232721001584	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
232721001585	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
232721001586	Walker A motif; other site
232721001587	ATP binding site [chemical binding]; other site
232721001588	Walker B motif; other site
232721001589	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
232721001590	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
232721001591	ligand binding site [chemical binding]; other site
232721001592	flexible hinge region; other site
232721001593	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
232721001594	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
232721001595	Walker A motif; other site
232721001596	ATP binding site [chemical binding]; other site
232721001597	Walker B motif; other site
232721001598	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
232721001599	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
232721001600	catalytic residue [active]
232721001601	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
232721001602	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721001603	catalytic residue [active]
232721001604	Protein of unknown function (DUF445); Region: DUF445; pfam04286
232721001605	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
232721001606	FAD binding domain; Region: FAD_binding_4; pfam01565
232721001607	MT-A70; Region: MT-A70; cl01947
232721001608	Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195
232721001609	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
232721001610	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
232721001611	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
232721001612	putative active site [active]
232721001613	putative substrate binding site [chemical binding]; other site
232721001614	putative cosubstrate binding site; other site
232721001615	catalytic site [active]
232721001616	Protein of unknown function, DUF399; Region: DUF399; cl01139
232721001617	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
232721001618	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
232721001619	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
232721001620	active site
232721001621	dimer interface [polypeptide binding]; other site
232721001622	effector binding site; other site
232721001623	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
232721001624	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
232721001625	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721001626	dimerization interface [polypeptide binding]; other site
232721001627	GAF domain; Region: GAF; pfam01590
232721001628	Histidine kinase; Region: HisKA_3; pfam07730
232721001629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721001630	ATP binding site [chemical binding]; other site
232721001631	Mg2+ binding site [ion binding]; other site
232721001632	G-X-G motif; other site
232721001633	transcriptional regulator NarL; Provisional; Region: PRK10651
232721001634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721001635	active site
232721001636	phosphorylation site [posttranslational modification]
232721001637	intermolecular recognition site; other site
232721001638	dimerization interface [polypeptide binding]; other site
232721001639	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
232721001640	DNA binding residues [nucleotide binding]
232721001641	dimerization interface [polypeptide binding]; other site
232721001642	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
232721001643	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721001644	putative substrate translocation pore; other site
232721001645	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
232721001646	CCC1-related family of proteins; Region: CCC1_like; cl00278
232721001647	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
232721001648	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
232721001649	[4Fe-4S] binding site [ion binding]; other site
232721001650	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
232721001651	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
232721001652	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
232721001653	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
232721001654	molybdopterin cofactor binding site; other site
232721001655	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
232721001656	4Fe-4S binding domain; Region: Fer4; cl02805
232721001657	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
232721001658	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
232721001659	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
232721001660	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
232721001661	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
232721001662	active site clefts [active]
232721001663	zinc binding site [ion binding]; other site
232721001664	dimer interface [polypeptide binding]; other site
232721001665	NnrS protein; Region: NnrS; pfam05940
232721001666	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
232721001667	putative FMN binding site [chemical binding]; other site
232721001668	Hemerythrin-like domain; Region: Hr-like; cd12108
232721001669	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
232721001670	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
232721001671	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
232721001672	Transcriptional regulator [Transcription]; Region: IclR; COG1414
232721001673	Bacterial transcriptional regulator; Region: IclR; pfam01614
232721001674	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
232721001675	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
232721001676	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721001677	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
232721001678	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
232721001679	putative [4Fe-4S] binding site [ion binding]; other site
232721001680	putative molybdopterin cofactor binding site [chemical binding]; other site
232721001681	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
232721001682	putative molybdopterin cofactor binding site; other site
232721001683	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
232721001684	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
232721001685	putative ligand binding site [chemical binding]; other site
232721001686	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
232721001687	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
232721001688	metal binding site [ion binding]; metal-binding site
232721001689	putative dimer interface [polypeptide binding]; other site
232721001690	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
232721001691	putative active site [active]
232721001692	Zn binding site [ion binding]; other site
232721001693	Acyl CoA binding protein; Region: ACBP; pfam00887
232721001694	acyl-CoA binding pocket [chemical binding]; other site
232721001695	CoA binding site [chemical binding]; other site
232721001696	Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023
232721001697	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
232721001698	exopolyphosphatase; Region: exo_poly_only; TIGR03706
232721001699	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
232721001700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721001701	S-adenosylmethionine binding site [chemical binding]; other site
232721001702	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
232721001703	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721001704	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721001705	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
232721001706	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721001707	acyl-activating enzyme (AAE) consensus motif; other site
232721001708	active site
232721001709	AMP binding site [chemical binding]; other site
232721001710	CoA binding site [chemical binding]; other site
232721001711	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
232721001712	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
232721001713	Walker A/P-loop; other site
232721001714	ATP binding site [chemical binding]; other site
232721001715	Q-loop/lid; other site
232721001716	ABC transporter signature motif; other site
232721001717	Walker B; other site
232721001718	D-loop; other site
232721001719	H-loop/switch region; other site
232721001720	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
232721001721	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
232721001722	putative ligand binding site [chemical binding]; other site
232721001723	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
232721001724	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
232721001725	TM-ABC transporter signature motif; other site
232721001726	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
232721001727	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
232721001728	TM-ABC transporter signature motif; other site
232721001729	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
232721001730	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
232721001731	Walker A/P-loop; other site
232721001732	ATP binding site [chemical binding]; other site
232721001733	Q-loop/lid; other site
232721001734	ABC transporter signature motif; other site
232721001735	Walker B; other site
232721001736	D-loop; other site
232721001737	H-loop/switch region; other site
232721001738	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
232721001739	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721001740	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
232721001741	acyl-activating enzyme (AAE) consensus motif; other site
232721001742	putative AMP binding site [chemical binding]; other site
232721001743	putative active site [active]
232721001744	putative CoA binding site [chemical binding]; other site
232721001745	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
232721001746	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721001747	Walker A motif; other site
232721001748	ATP binding site [chemical binding]; other site
232721001749	Walker B motif; other site
232721001750	arginine finger; other site
232721001751	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
232721001752	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
232721001753	ligand binding site [chemical binding]; other site
232721001754	flexible hinge region; other site
232721001755	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
232721001756	non-specific DNA interactions [nucleotide binding]; other site
232721001757	DNA binding site [nucleotide binding]
232721001758	sequence specific DNA binding site [nucleotide binding]; other site
232721001759	putative cAMP binding site [chemical binding]; other site
232721001760	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
232721001761	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
232721001762	RNA binding surface [nucleotide binding]; other site
232721001763	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
232721001764	active site
232721001765	heat shock protein 90; Provisional; Region: PRK05218
232721001766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721001767	ATP binding site [chemical binding]; other site
232721001768	Mg2+ binding site [ion binding]; other site
232721001769	G-X-G motif; other site
232721001770	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721001771	exosortase H, IPTLxxWG-CTERM-specific; Region: exosort_XrtH; TIGR04177
232721001772	serine/threonine protein kinase; Provisional; Region: PRK11768
232721001773	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
232721001774	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
232721001775	Catalytic domain of Protein Kinases; Region: PKc; cd00180
232721001776	active site
232721001777	ATP binding site [chemical binding]; other site
232721001778	substrate binding site [chemical binding]; other site
232721001779	activation loop (A-loop); other site
232721001780	Universal stress protein family; Region: Usp; pfam00582
232721001781	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
232721001782	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
232721001783	active site
232721001784	metal binding site [ion binding]; metal-binding site
232721001785	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
232721001786	Transcriptional regulators [Transcription]; Region: MarR; COG1846
232721001787	MarR family; Region: MarR; pfam01047
232721001788	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
232721001789	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
232721001790	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736
232721001791	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
232721001792	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
232721001793	CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562
232721001794	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
232721001795	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
232721001796	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
232721001797	dimer interface [polypeptide binding]; other site
232721001798	active site
232721001799	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
232721001800	substrate binding site [chemical binding]; other site
232721001801	catalytic residue [active]
232721001802	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
232721001803	catalytic core [active]
232721001804	hypothetical protein; Provisional; Region: PRK11667
232721001805	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
232721001806	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
232721001807	Ligand Binding Site [chemical binding]; other site
232721001808	Dihydroneopterin aldolase; Region: FolB; smart00905
232721001809	active site
232721001810	short chain dehydrogenase; Provisional; Region: PRK09134
232721001811	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721001812	NAD(P) binding site [chemical binding]; other site
232721001813	active site
232721001814	Uncharacterized conserved protein [Function unknown]; Region: COG1565
232721001815	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
232721001816	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
232721001817	nucleotide binding site [chemical binding]; other site
232721001818	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
232721001819	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
232721001820	active site
232721001821	homotetramer interface [polypeptide binding]; other site
232721001822	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
232721001823	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
232721001824	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
232721001825	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721001826	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
232721001827	active site
232721001828	motif I; other site
232721001829	motif II; other site
232721001830	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
232721001831	thioredoxin 2; Provisional; Region: PRK10996
232721001832	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
232721001833	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
232721001834	catalytic residues [active]
232721001835	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
232721001836	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
232721001837	active site
232721001838	NTP binding site [chemical binding]; other site
232721001839	metal binding triad [ion binding]; metal-binding site
232721001840	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
232721001841	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
232721001842	Zn2+ binding site [ion binding]; other site
232721001843	Mg2+ binding site [ion binding]; other site
232721001844	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
232721001845	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
232721001846	putative active site [active]
232721001847	putative metal binding site [ion binding]; other site
232721001848	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
232721001849	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
232721001850	putative C-terminal domain interface [polypeptide binding]; other site
232721001851	putative GSH binding site (G-site) [chemical binding]; other site
232721001852	putative dimer interface [polypeptide binding]; other site
232721001853	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
232721001854	putative dimer interface [polypeptide binding]; other site
232721001855	putative N-terminal domain interface [polypeptide binding]; other site
232721001856	putative substrate binding pocket (H-site) [chemical binding]; other site
232721001857	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
232721001858	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
232721001859	lytic murein transglycosylase; Provisional; Region: PRK11619
232721001860	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721001861	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721001862	catalytic residue [active]
232721001863	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
232721001864	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
232721001865	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
232721001866	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
232721001867	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
232721001868	active site
232721001869	substrate binding site [chemical binding]; other site
232721001870	FMN binding site [chemical binding]; other site
232721001871	putative catalytic residues [active]
232721001872	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
232721001873	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
232721001874	N-terminal plug; other site
232721001875	ligand-binding site [chemical binding]; other site
232721001876	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
232721001877	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
232721001878	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
232721001879	acyl-activating enzyme (AAE) consensus motif; other site
232721001880	putative AMP binding site [chemical binding]; other site
232721001881	putative active site [active]
232721001882	putative CoA binding site [chemical binding]; other site
232721001883	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
232721001884	PGAP1-like protein; Region: PGAP1; pfam07819
232721001885	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
232721001886	cofactor binding site; other site
232721001887	metal binding site [ion binding]; metal-binding site
232721001888	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721001889	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
232721001890	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
232721001891	dimer interface [polypeptide binding]; other site
232721001892	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
232721001893	active site
232721001894	Fe binding site [ion binding]; other site
232721001895	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721001896	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721001897	dimerization interface [polypeptide binding]; other site
232721001898	putative DNA binding site [nucleotide binding]; other site
232721001899	putative Zn2+ binding site [ion binding]; other site
232721001900	AsnC family; Region: AsnC_trans_reg; pfam01037
232721001901	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
232721001902	Coenzyme A binding pocket [chemical binding]; other site
232721001903	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
232721001904	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
232721001905	Transporter associated domain; Region: CorC_HlyC; smart01091
232721001906	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
232721001907	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
232721001908	putative active site [active]
232721001909	catalytic triad [active]
232721001910	putative dimer interface [polypeptide binding]; other site
232721001911	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
232721001912	dimer interface [polypeptide binding]; other site
232721001913	active site 1 [active]
232721001914	active site 2 [active]
232721001915	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
232721001916	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
232721001917	dimer interface [polypeptide binding]; other site
232721001918	active site
232721001919	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
232721001920	dimer interface [polypeptide binding]; other site
232721001921	motif 1; other site
232721001922	active site
232721001923	motif 2; other site
232721001924	motif 3; other site
232721001925	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
232721001926	DALR anticodon binding domain; Region: DALR_1; pfam05746
232721001927	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
232721001928	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721001929	active site
232721001930	motif I; other site
232721001931	motif II; other site
232721001932	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
232721001933	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
232721001934	putative acyl-acceptor binding pocket; other site
232721001935	Protein of unknown function DUF45; Region: DUF45; pfam01863
232721001936	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
232721001937	active site residue [active]
232721001938	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
232721001939	BON domain; Region: BON; pfam04972
232721001940	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
232721001941	pantothenate kinase; Reviewed; Region: PRK13329
232721001942	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
232721001943	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721001944	Bacterial transcriptional repressor; Region: TetR; pfam13972
232721001945	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
232721001946	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
232721001947	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
232721001948	NAD binding site [chemical binding]; other site
232721001949	substrate binding site [chemical binding]; other site
232721001950	homodimer interface [polypeptide binding]; other site
232721001951	active site
232721001952	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
232721001953	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
232721001954	NADP binding site [chemical binding]; other site
232721001955	active site
232721001956	putative substrate binding site [chemical binding]; other site
232721001957	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
232721001958	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
232721001959	substrate binding site; other site
232721001960	tetramer interface; other site
232721001961	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
232721001962	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
232721001963	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
232721001964	Ligand binding site; other site
232721001965	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
232721001966	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
232721001967	active site
232721001968	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
232721001969	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
232721001970	Probable Catalytic site; other site
232721001971	metal-binding site
232721001972	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
232721001973	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
232721001974	Probable Catalytic site; other site
232721001975	metal-binding site
232721001976	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
232721001977	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
232721001978	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
232721001979	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
232721001980	Walker A/P-loop; other site
232721001981	ATP binding site [chemical binding]; other site
232721001982	Q-loop/lid; other site
232721001983	ABC transporter signature motif; other site
232721001984	Walker B; other site
232721001985	D-loop; other site
232721001986	H-loop/switch region; other site
232721001987	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
232721001988	putative carbohydrate binding site [chemical binding]; other site
232721001989	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
232721001990	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721001991	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
232721001992	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
232721001993	putative trimer interface [polypeptide binding]; other site
232721001994	putative CoA binding site [chemical binding]; other site
232721001995	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
232721001996	Homeodomain-like domain; Region: HTH_23; pfam13384
232721001997	Winged helix-turn helix; Region: HTH_29; pfam13551
232721001998	Homeodomain-like domain; Region: HTH_32; pfam13565
232721001999	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721002000	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721002001	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
232721002002	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
232721002003	Ligand binding site; other site
232721002004	Putative Catalytic site; other site
232721002005	DXD motif; other site
232721002006	Predicted membrane protein [Function unknown]; Region: COG2246
232721002007	GtrA-like protein; Region: GtrA; pfam04138
232721002008	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
232721002009	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
232721002010	inhibitor-cofactor binding pocket; inhibition site
232721002011	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721002012	catalytic residue [active]
232721002013	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
232721002014	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
232721002015	HAMP domain; Region: HAMP; pfam00672
232721002016	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
232721002017	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721002018	dimer interface [polypeptide binding]; other site
232721002019	phosphorylation site [posttranslational modification]
232721002020	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721002021	ATP binding site [chemical binding]; other site
232721002022	Mg2+ binding site [ion binding]; other site
232721002023	G-X-G motif; other site
232721002024	Response regulator receiver domain; Region: Response_reg; pfam00072
232721002025	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721002026	active site
232721002027	phosphorylation site [posttranslational modification]
232721002028	intermolecular recognition site; other site
232721002029	dimerization interface [polypeptide binding]; other site
232721002030	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
232721002031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721002032	active site
232721002033	phosphorylation site [posttranslational modification]
232721002034	intermolecular recognition site; other site
232721002035	dimerization interface [polypeptide binding]; other site
232721002036	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
232721002037	DNA binding residues [nucleotide binding]
232721002038	dimerization interface [polypeptide binding]; other site
232721002039	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
232721002040	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
232721002041	active site
232721002042	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
232721002043	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721002044	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
232721002045	putative ADP-binding pocket [chemical binding]; other site
232721002046	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
232721002047	cofactor binding site; other site
232721002048	DNA binding site [nucleotide binding]
232721002049	substrate interaction site [chemical binding]; other site
232721002050	RES domain; Region: RES; pfam08808
232721002051	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
232721002052	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
232721002053	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
232721002054	Transposase; Region: HTH_Tnp_1; pfam01527
232721002055	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
232721002056	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
232721002057	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
232721002058	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
232721002059	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
232721002060	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
232721002061	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
232721002062	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
232721002063	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
232721002064	Transposase domain (DUF772); Region: DUF772; pfam05598
232721002065	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721002066	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721002067	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
232721002068	putative ADP-binding pocket [chemical binding]; other site
232721002069	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721002070	SapC; Region: SapC; pfam07277
232721002071	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
232721002072	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
232721002073	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
232721002074	Walker A/P-loop; other site
232721002075	ATP binding site [chemical binding]; other site
232721002076	Q-loop/lid; other site
232721002077	ABC transporter signature motif; other site
232721002078	Walker B; other site
232721002079	D-loop; other site
232721002080	H-loop/switch region; other site
232721002081	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
232721002082	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
232721002083	Walker A/P-loop; other site
232721002084	ATP binding site [chemical binding]; other site
232721002085	Q-loop/lid; other site
232721002086	ABC transporter signature motif; other site
232721002087	Walker B; other site
232721002088	D-loop; other site
232721002089	H-loop/switch region; other site
232721002090	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
232721002091	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
232721002092	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721002093	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
232721002094	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
232721002095	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
232721002096	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721002097	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
232721002098	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
232721002099	Mg++ binding site [ion binding]; other site
232721002100	putative catalytic motif [active]
232721002101	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
232721002102	feedback inhibition sensing region; other site
232721002103	homohexameric interface [polypeptide binding]; other site
232721002104	nucleotide binding site [chemical binding]; other site
232721002105	N-acetyl-L-glutamate binding site [chemical binding]; other site
232721002106	division inhibitor protein; Provisional; Region: slmA; PRK09480
232721002107	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721002108	Transposase domain (DUF772); Region: DUF772; pfam05598
232721002109	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721002110	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721002111	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
232721002112	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721002113	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
232721002114	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
232721002115	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721002116	active site
232721002117	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
232721002118	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
232721002119	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
232721002120	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
232721002121	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
232721002122	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
232721002123	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721002124	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
232721002125	substrate binding site [chemical binding]; other site
232721002126	oxyanion hole (OAH) forming residues; other site
232721002127	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
232721002128	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721002129	dimer interface [polypeptide binding]; other site
232721002130	active site
232721002131	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
232721002132	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
232721002133	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
232721002134	enoyl-CoA hydratase; Provisional; Region: PRK06688
232721002135	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721002136	substrate binding site [chemical binding]; other site
232721002137	oxyanion hole (OAH) forming residues; other site
232721002138	trimer interface [polypeptide binding]; other site
232721002139	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
232721002140	CoenzymeA binding site [chemical binding]; other site
232721002141	subunit interaction site [polypeptide binding]; other site
232721002142	PHB binding site; other site
232721002143	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
232721002144	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
232721002145	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
232721002146	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
232721002147	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
232721002148	Walker A/P-loop; other site
232721002149	ATP binding site [chemical binding]; other site
232721002150	Q-loop/lid; other site
232721002151	ABC transporter signature motif; other site
232721002152	Walker B; other site
232721002153	D-loop; other site
232721002154	H-loop/switch region; other site
232721002155	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
232721002156	homodimer interface [polypeptide binding]; other site
232721002157	chemical substrate binding site [chemical binding]; other site
232721002158	oligomer interface [polypeptide binding]; other site
232721002159	metal binding site [ion binding]; metal-binding site
232721002160	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
232721002161	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
232721002162	DctM-like transporters; Region: DctM; pfam06808
232721002163	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
232721002164	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
232721002165	cell density-dependent motility repressor; Provisional; Region: PRK10082
232721002166	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721002167	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
232721002168	dimerization interface [polypeptide binding]; other site
232721002169	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
232721002170	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
232721002171	substrate binding pocket [chemical binding]; other site
232721002172	membrane-bound complex binding site; other site
232721002173	hinge residues; other site
232721002174	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
232721002175	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
232721002176	substrate binding pocket [chemical binding]; other site
232721002177	membrane-bound complex binding site; other site
232721002178	hinge residues; other site
232721002179	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721002180	dimer interface [polypeptide binding]; other site
232721002181	conserved gate region; other site
232721002182	putative PBP binding loops; other site
232721002183	ABC-ATPase subunit interface; other site
232721002184	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
232721002185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721002186	dimer interface [polypeptide binding]; other site
232721002187	conserved gate region; other site
232721002188	putative PBP binding loops; other site
232721002189	ABC-ATPase subunit interface; other site
232721002190	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
232721002191	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
232721002192	Walker A/P-loop; other site
232721002193	ATP binding site [chemical binding]; other site
232721002194	Q-loop/lid; other site
232721002195	ABC transporter signature motif; other site
232721002196	Walker B; other site
232721002197	D-loop; other site
232721002198	H-loop/switch region; other site
232721002199	Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423
232721002200	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
232721002201	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721002202	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
232721002203	AsnC family; Region: AsnC_trans_reg; pfam01037
232721002204	Cytochrome c; Region: Cytochrom_C; cl11414
232721002205	Cytochrome c; Region: Cytochrom_C; cl11414
232721002206	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
232721002207	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
232721002208	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
232721002209	G1 box; other site
232721002210	putative GEF interaction site [polypeptide binding]; other site
232721002211	GTP/Mg2+ binding site [chemical binding]; other site
232721002212	Switch I region; other site
232721002213	G2 box; other site
232721002214	G3 box; other site
232721002215	Switch II region; other site
232721002216	G4 box; other site
232721002217	G5 box; other site
232721002218	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
232721002219	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
232721002220	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
232721002221	homotetramer interface [polypeptide binding]; other site
232721002222	ligand binding site [chemical binding]; other site
232721002223	catalytic site [active]
232721002224	NAD binding site [chemical binding]; other site
232721002225	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
232721002226	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
232721002227	FtsJ-like methyltransferase; Region: FtsJ; cl17430
232721002228	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
232721002229	FAD binding site [chemical binding]; other site
232721002230	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
232721002231	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
232721002232	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
232721002233	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
232721002234	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
232721002235	Catalytic domain of Protein Kinases; Region: PKc; cd00180
232721002236	active site
232721002237	ATP binding site [chemical binding]; other site
232721002238	substrate binding site [chemical binding]; other site
232721002239	activation loop (A-loop); other site
232721002240	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
232721002241	23S rRNA interface [nucleotide binding]; other site
232721002242	L3 interface [polypeptide binding]; other site
232721002243	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
232721002244	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
232721002245	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
232721002246	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
232721002247	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
232721002248	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
232721002249	Peptidase family M23; Region: Peptidase_M23; pfam01551
232721002250	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
232721002251	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
232721002252	active site
232721002253	HIGH motif; other site
232721002254	dimer interface [polypeptide binding]; other site
232721002255	KMSKS motif; other site
232721002256	Hemerythrin; Region: Hemerythrin; cd12107
232721002257	Fe binding site [ion binding]; other site
232721002258	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721002259	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
232721002260	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721002261	dimerization interface [polypeptide binding]; other site
232721002262	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
232721002263	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
232721002264	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
232721002265	Substrate binding site; other site
232721002266	Mg++ binding site; other site
232721002267	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
232721002268	active site
232721002269	substrate binding site [chemical binding]; other site
232721002270	CoA binding site [chemical binding]; other site
232721002271	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721002272	dimer interface [polypeptide binding]; other site
232721002273	phosphorylation site [posttranslational modification]
232721002274	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721002275	ATP binding site [chemical binding]; other site
232721002276	Mg2+ binding site [ion binding]; other site
232721002277	G-X-G motif; other site
232721002278	chaperone protein DnaJ; Provisional; Region: PRK14299
232721002279	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
232721002280	HSP70 interaction site [polypeptide binding]; other site
232721002281	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
232721002282	substrate binding site [polypeptide binding]; other site
232721002283	dimer interface [polypeptide binding]; other site
232721002284	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721002285	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
232721002286	AsnC family; Region: AsnC_trans_reg; pfam01037
232721002287	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
232721002288	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
232721002289	glutaminase active site [active]
232721002290	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
232721002291	dimer interface [polypeptide binding]; other site
232721002292	active site
232721002293	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
232721002294	dimer interface [polypeptide binding]; other site
232721002295	active site
232721002296	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
232721002297	NADH(P)-binding; Region: NAD_binding_10; pfam13460
232721002298	NAD binding site [chemical binding]; other site
232721002299	substrate binding site [chemical binding]; other site
232721002300	putative active site [active]
232721002301	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721002302	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721002303	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
232721002304	putative effector binding pocket; other site
232721002305	dimerization interface [polypeptide binding]; other site
232721002306	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
232721002307	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
232721002308	putative NAD(P) binding site [chemical binding]; other site
232721002309	putative substrate binding site [chemical binding]; other site
232721002310	catalytic Zn binding site [ion binding]; other site
232721002311	structural Zn binding site [ion binding]; other site
232721002312	dimer interface [polypeptide binding]; other site
232721002313	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
232721002314	rRNA binding site [nucleotide binding]; other site
232721002315	predicted 30S ribosome binding site; other site
232721002316	CHASE3 domain; Region: CHASE3; pfam05227
232721002317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
232721002318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721002319	dimer interface [polypeptide binding]; other site
232721002320	phosphorylation site [posttranslational modification]
232721002321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721002322	ATP binding site [chemical binding]; other site
232721002323	Mg2+ binding site [ion binding]; other site
232721002324	G-X-G motif; other site
232721002325	Response regulator receiver domain; Region: Response_reg; pfam00072
232721002326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721002327	active site
232721002328	phosphorylation site [posttranslational modification]
232721002329	intermolecular recognition site; other site
232721002330	dimerization interface [polypeptide binding]; other site
232721002331	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
232721002332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721002333	active site
232721002334	phosphorylation site [posttranslational modification]
232721002335	intermolecular recognition site; other site
232721002336	dimerization interface [polypeptide binding]; other site
232721002337	Response regulator receiver domain; Region: Response_reg; pfam00072
232721002338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721002339	active site
232721002340	phosphorylation site [posttranslational modification]
232721002341	intermolecular recognition site; other site
232721002342	dimerization interface [polypeptide binding]; other site
232721002343	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
232721002344	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
232721002345	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
232721002346	CheB methylesterase; Region: CheB_methylest; pfam01339
232721002347	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
232721002348	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721002349	active site
232721002350	phosphorylation site [posttranslational modification]
232721002351	intermolecular recognition site; other site
232721002352	dimerization interface [polypeptide binding]; other site
232721002353	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
232721002354	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721002355	dimer interface [polypeptide binding]; other site
232721002356	phosphorylation site [posttranslational modification]
232721002357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721002358	ATP binding site [chemical binding]; other site
232721002359	Mg2+ binding site [ion binding]; other site
232721002360	G-X-G motif; other site
232721002361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721002362	active site
232721002363	phosphorylation site [posttranslational modification]
232721002364	intermolecular recognition site; other site
232721002365	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
232721002366	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
232721002367	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721002368	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
232721002369	acyl-activating enzyme (AAE) consensus motif; other site
232721002370	acyl-activating enzyme (AAE) consensus motif; other site
232721002371	putative AMP binding site [chemical binding]; other site
232721002372	putative active site [active]
232721002373	putative CoA binding site [chemical binding]; other site
232721002374	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
232721002375	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
232721002376	catalytic residues [active]
232721002377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
232721002378	CreA protein; Region: CreA; pfam05981
232721002379	cyanophycin synthetase; Provisional; Region: PRK14016
232721002380	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
232721002381	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
232721002382	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
232721002383	cyanophycin synthetase; Provisional; Region: PRK14016
232721002384	ATP-grasp domain; Region: ATP-grasp_4; cl17255
232721002385	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
232721002386	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
232721002387	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
232721002388	Walker A/P-loop; other site
232721002389	ATP binding site [chemical binding]; other site
232721002390	Q-loop/lid; other site
232721002391	ABC transporter signature motif; other site
232721002392	Walker B; other site
232721002393	D-loop; other site
232721002394	H-loop/switch region; other site
232721002395	Domain of unknown function (DUF1854); Region: DUF1854; pfam08909
232721002396	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
232721002397	EF-hand domain pair; Region: EF_hand_5; pfam13499
232721002398	Ca2+ binding site [ion binding]; other site
232721002399	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
232721002400	type II secretion system protein F; Region: GspF; TIGR02120
232721002401	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
232721002402	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
232721002403	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
232721002404	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
232721002405	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
232721002406	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
232721002407	type II secretion system protein E; Region: type_II_gspE; TIGR02533
232721002408	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
232721002409	Walker A motif; other site
232721002410	ATP binding site [chemical binding]; other site
232721002411	Walker B motif; other site
232721002412	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
232721002413	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
232721002414	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
232721002415	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
232721002416	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
232721002417	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
232721002418	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
232721002419	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
232721002420	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
232721002421	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
232721002422	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
232721002423	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
232721002424	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
232721002425	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
232721002426	cobalamin synthase; Reviewed; Region: cobS; PRK00235
232721002427	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
232721002428	threonine dehydratase; Reviewed; Region: PRK09224
232721002429	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
232721002430	tetramer interface [polypeptide binding]; other site
232721002431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721002432	catalytic residue [active]
232721002433	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
232721002434	putative Ile/Val binding site [chemical binding]; other site
232721002435	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
232721002436	putative Ile/Val binding site [chemical binding]; other site
232721002437	OsmC-like protein; Region: OsmC; cl00767
232721002438	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
232721002439	diiron binding motif [ion binding]; other site
232721002440	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
232721002441	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
232721002442	trimer interface [polypeptide binding]; other site
232721002443	eyelet of channel; other site
232721002444	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
232721002445	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
232721002446	trimer interface [polypeptide binding]; other site
232721002447	eyelet of channel; other site
232721002448	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
232721002449	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
232721002450	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
232721002451	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721002452	dimer interface [polypeptide binding]; other site
232721002453	conserved gate region; other site
232721002454	putative PBP binding loops; other site
232721002455	ABC-ATPase subunit interface; other site
232721002456	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
232721002457	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
232721002458	metal binding site [ion binding]; metal-binding site
232721002459	putative dimer interface [polypeptide binding]; other site
232721002460	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
232721002461	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
232721002462	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
232721002463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721002464	dimer interface [polypeptide binding]; other site
232721002465	conserved gate region; other site
232721002466	putative PBP binding loops; other site
232721002467	ABC-ATPase subunit interface; other site
232721002468	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
232721002469	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
232721002470	Walker A/P-loop; other site
232721002471	ATP binding site [chemical binding]; other site
232721002472	Q-loop/lid; other site
232721002473	ABC transporter signature motif; other site
232721002474	Walker B; other site
232721002475	D-loop; other site
232721002476	H-loop/switch region; other site
232721002477	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
232721002478	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
232721002479	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
232721002480	Walker A/P-loop; other site
232721002481	ATP binding site [chemical binding]; other site
232721002482	Q-loop/lid; other site
232721002483	ABC transporter signature motif; other site
232721002484	Walker B; other site
232721002485	D-loop; other site
232721002486	H-loop/switch region; other site
232721002487	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
232721002488	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
232721002489	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
232721002490	active site
232721002491	metal binding site [ion binding]; metal-binding site
232721002492	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
232721002493	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
232721002494	substrate binding site [chemical binding]; other site
232721002495	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
232721002496	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
232721002497	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
232721002498	putative active site [active]
232721002499	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
232721002500	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
232721002501	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
232721002502	transaldolase-like protein; Provisional; Region: PTZ00411
232721002503	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
232721002504	active site
232721002505	dimer interface [polypeptide binding]; other site
232721002506	catalytic residue [active]
232721002507	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
232721002508	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
232721002509	active site
232721002510	dimer interface [polypeptide binding]; other site
232721002511	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
232721002512	dimer interface [polypeptide binding]; other site
232721002513	active site
232721002514	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721002515	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721002516	metal binding site [ion binding]; metal-binding site
232721002517	active site
232721002518	I-site; other site
232721002519	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
232721002520	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
232721002521	ring oligomerisation interface [polypeptide binding]; other site
232721002522	ATP/Mg binding site [chemical binding]; other site
232721002523	stacking interactions; other site
232721002524	hinge regions; other site
232721002525	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
232721002526	oligomerisation interface [polypeptide binding]; other site
232721002527	mobile loop; other site
232721002528	roof hairpin; other site
232721002529	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
232721002530	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
232721002531	active site
232721002532	nucleotide binding site [chemical binding]; other site
232721002533	HIGH motif; other site
232721002534	KMSKS motif; other site
232721002535	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
232721002536	nudix motif; other site
232721002537	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
232721002538	catalytic triad [active]
232721002539	conserved cis-peptide bond; other site
232721002540	S-adenosylmethionine synthetase; Validated; Region: PRK05250
232721002541	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
232721002542	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
232721002543	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
232721002544	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
232721002545	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
232721002546	putative acyl-acceptor binding pocket; other site
232721002547	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
232721002548	putative acyl-acceptor binding pocket; other site
232721002549	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
232721002550	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
232721002551	G1 box; other site
232721002552	GTP/Mg2+ binding site [chemical binding]; other site
232721002553	Switch I region; other site
232721002554	G2 box; other site
232721002555	G3 box; other site
232721002556	Switch II region; other site
232721002557	G4 box; other site
232721002558	G5 box; other site
232721002559	Cytochrome c553 [Energy production and conversion]; Region: COG2863
232721002560	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
232721002561	Cytochrome c; Region: Cytochrom_C; cl11414
232721002562	ResB-like family; Region: ResB; pfam05140
232721002563	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
232721002564	ResB-like family; Region: ResB; pfam05140
232721002565	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
232721002566	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
232721002567	TMAO/DMSO reductase; Reviewed; Region: PRK05363
232721002568	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
232721002569	Moco binding site; other site
232721002570	metal coordination site [ion binding]; other site
232721002571	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
232721002572	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
232721002573	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
232721002574	diaminopimelate decarboxylase; Region: lysA; TIGR01048
232721002575	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
232721002576	active site
232721002577	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
232721002578	substrate binding site [chemical binding]; other site
232721002579	catalytic residues [active]
232721002580	dimer interface [polypeptide binding]; other site
232721002581	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
232721002582	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
232721002583	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
232721002584	catalytic residues [active]
232721002585	catalytic nucleophile [active]
232721002586	Presynaptic Site I dimer interface [polypeptide binding]; other site
232721002587	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
232721002588	Synaptic Flat tetramer interface [polypeptide binding]; other site
232721002589	Synaptic Site I dimer interface [polypeptide binding]; other site
232721002590	DNA binding site [nucleotide binding]
232721002591	Zonular occludens toxin (Zot); Region: Zot; cl17485
232721002592	Protein of unknown function (DUF2523); Region: DUF2523; pfam10734
232721002593	Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616
232721002594	Replication initiation factor; Region: Rep_trans; pfam02486
232721002595	Frataxin-like domain; Region: Frataxin_Cyay; pfam01491
232721002596	putative iron binding site [ion binding]; other site
232721002597	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
232721002598	Transglycosylase; Region: Transgly; pfam00912
232721002599	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
232721002600	Competence protein A; Region: Competence_A; pfam11104
232721002601	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
232721002602	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
232721002603	nucleotide binding site [chemical binding]; other site
232721002604	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
232721002605	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
232721002606	Pilus assembly protein, PilO; Region: PilO; pfam04350
232721002607	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
232721002608	Pilus assembly protein, PilP; Region: PilP; pfam04351
232721002609	AMIN domain; Region: AMIN; pfam11741
232721002610	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
232721002611	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
232721002612	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
232721002613	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
232721002614	active site
232721002615	dimer interface [polypeptide binding]; other site
232721002616	metal binding site [ion binding]; metal-binding site
232721002617	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
232721002618	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
232721002619	Zn2+ binding site [ion binding]; other site
232721002620	Mg2+ binding site [ion binding]; other site
232721002621	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
232721002622	Protein of unknown function (DUF1415); Region: DUF1415; cl01301
232721002623	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721002624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721002625	Walker A motif; other site
232721002626	ATP binding site [chemical binding]; other site
232721002627	Walker B motif; other site
232721002628	arginine finger; other site
232721002629	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721002630	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
232721002631	Integrase core domain; Region: rve; pfam00665
232721002632	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
232721002633	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
232721002634	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
232721002635	active site
232721002636	dimer interface [polypeptide binding]; other site
232721002637	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
232721002638	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
232721002639	active site
232721002640	FMN binding site [chemical binding]; other site
232721002641	substrate binding site [chemical binding]; other site
232721002642	3Fe-4S cluster binding site [ion binding]; other site
232721002643	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
232721002644	domain interface; other site
232721002645	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
232721002646	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
232721002647	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
232721002648	substrate binding pocket [chemical binding]; other site
232721002649	membrane-bound complex binding site; other site
232721002650	hinge residues; other site
232721002651	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
232721002652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721002653	dimer interface [polypeptide binding]; other site
232721002654	conserved gate region; other site
232721002655	putative PBP binding loops; other site
232721002656	ABC-ATPase subunit interface; other site
232721002657	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
232721002658	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
232721002659	Walker A/P-loop; other site
232721002660	ATP binding site [chemical binding]; other site
232721002661	Q-loop/lid; other site
232721002662	ABC transporter signature motif; other site
232721002663	Walker B; other site
232721002664	D-loop; other site
232721002665	H-loop/switch region; other site
232721002666	spermidine synthase; Provisional; Region: PRK00811
232721002667	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721002668	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675
232721002669	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
232721002670	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
232721002671	Walker A/P-loop; other site
232721002672	ATP binding site [chemical binding]; other site
232721002673	Q-loop/lid; other site
232721002674	ABC transporter signature motif; other site
232721002675	Walker B; other site
232721002676	D-loop; other site
232721002677	H-loop/switch region; other site
232721002678	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
232721002679	Permease; Region: Permease; pfam02405
232721002680	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
232721002681	mce related protein; Region: MCE; pfam02470
232721002682	VacJ like lipoprotein; Region: VacJ; cl01073
232721002683	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
232721002684	STAS domain; Region: STAS_2; pfam13466
232721002685	Transposase domain (DUF772); Region: DUF772; pfam05598
232721002686	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721002687	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721002688	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
232721002689	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
232721002690	Walker A/P-loop; other site
232721002691	ATP binding site [chemical binding]; other site
232721002692	Q-loop/lid; other site
232721002693	ABC transporter signature motif; other site
232721002694	Walker B; other site
232721002695	D-loop; other site
232721002696	H-loop/switch region; other site
232721002697	ABC-2 type transporter; Region: ABC2_membrane; cl17235
232721002698	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
232721002699	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
232721002700	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
232721002701	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
232721002702	hinge; other site
232721002703	active site
232721002704	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
232721002705	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
232721002706	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
232721002707	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
232721002708	NAD binding site [chemical binding]; other site
232721002709	dimerization interface [polypeptide binding]; other site
232721002710	product binding site; other site
232721002711	substrate binding site [chemical binding]; other site
232721002712	zinc binding site [ion binding]; other site
232721002713	catalytic residues [active]
232721002714	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
232721002715	putative active site [active]
232721002716	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
232721002717	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721002718	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721002719	homodimer interface [polypeptide binding]; other site
232721002720	catalytic residue [active]
232721002721	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
232721002722	putative active site pocket [active]
232721002723	4-fold oligomerization interface [polypeptide binding]; other site
232721002724	metal binding residues [ion binding]; metal-binding site
232721002725	3-fold/trimer interface [polypeptide binding]; other site
232721002726	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
232721002727	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
232721002728	putative active site [active]
232721002729	oxyanion strand; other site
232721002730	catalytic triad [active]
232721002731	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
232721002732	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
232721002733	catalytic residues [active]
232721002734	Spherulation-specific family 4; Region: Spherulin4; pfam12138
232721002735	Predicted membrane protein [Function unknown]; Region: COG4267
232721002736	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
232721002737	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721002738	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
232721002739	GAF domain; Region: GAF_3; pfam13492
232721002740	Tetratricopeptide repeat; Region: TPR_15; pfam13429
232721002741	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
232721002742	C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922
232721002743	putative active site [active]
232721002744	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
232721002745	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
232721002746	NAD binding site [chemical binding]; other site
232721002747	homodimer interface [polypeptide binding]; other site
232721002748	active site
232721002749	substrate binding site [chemical binding]; other site
232721002750	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
232721002751	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
232721002752	substrate binding site [chemical binding]; other site
232721002753	glutamase interaction surface [polypeptide binding]; other site
232721002754	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
232721002755	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
232721002756	metal binding site [ion binding]; metal-binding site
232721002757	Predicted membrane protein [Function unknown]; Region: COG3671
232721002758	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
232721002759	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
232721002760	active site
232721002761	nucleophile elbow; other site
232721002762	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
232721002763	nucleotide binding site/active site [active]
232721002764	HIT family signature motif; other site
232721002765	catalytic residue [active]
232721002766	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
232721002767	sec-independent translocase; Provisional; Region: tatB; PRK01919
232721002768	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
232721002769	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
232721002770	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
232721002771	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
232721002772	protein binding site [polypeptide binding]; other site
232721002773	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
232721002774	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
232721002775	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
232721002776	FAD binding pocket [chemical binding]; other site
232721002777	FAD binding motif [chemical binding]; other site
232721002778	phosphate binding motif [ion binding]; other site
232721002779	beta-alpha-beta structure motif; other site
232721002780	NAD binding pocket [chemical binding]; other site
232721002781	Uncharacterized conserved protein [Function unknown]; Region: COG0327
232721002782	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
232721002783	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
232721002784	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
232721002785	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
232721002786	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
232721002787	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
232721002788	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
232721002789	[2Fe-2S] cluster binding site [ion binding]; other site
232721002790	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
232721002791	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
232721002792	Qi binding site; other site
232721002793	intrachain domain interface; other site
232721002794	interchain domain interface [polypeptide binding]; other site
232721002795	heme bH binding site [chemical binding]; other site
232721002796	heme bL binding site [chemical binding]; other site
232721002797	Qo binding site; other site
232721002798	interchain domain interface [polypeptide binding]; other site
232721002799	intrachain domain interface; other site
232721002800	Qi binding site; other site
232721002801	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
232721002802	Qo binding site; other site
232721002803	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
232721002804	stringent starvation protein A; Provisional; Region: sspA; PRK09481
232721002805	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
232721002806	C-terminal domain interface [polypeptide binding]; other site
232721002807	putative GSH binding site (G-site) [chemical binding]; other site
232721002808	dimer interface [polypeptide binding]; other site
232721002809	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
232721002810	dimer interface [polypeptide binding]; other site
232721002811	N-terminal domain interface [polypeptide binding]; other site
232721002812	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
232721002813	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
232721002814	Peptidase family M23; Region: Peptidase_M23; pfam01551
232721002815	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
232721002816	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
232721002817	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
232721002818	nucleotide binding region [chemical binding]; other site
232721002819	SEC-C motif; Region: SEC-C; pfam02810
232721002820	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
232721002821	heterotetramer interface [polypeptide binding]; other site
232721002822	active site pocket [active]
232721002823	cleavage site
232721002824	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
232721002825	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721002826	Walker A motif; other site
232721002827	ATP binding site [chemical binding]; other site
232721002828	Walker B motif; other site
232721002829	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
232721002830	active site
232721002831	8-oxo-dGMP binding site [chemical binding]; other site
232721002832	nudix motif; other site
232721002833	metal binding site [ion binding]; metal-binding site
232721002834	Domain of unknown function (DUF329); Region: DUF329; pfam03884
232721002835	hypothetical protein; Provisional; Region: PRK05287
232721002836	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
232721002837	dephospho-CoA kinase; Region: TIGR00152
232721002838	CoA-binding site [chemical binding]; other site
232721002839	ATP-binding [chemical binding]; other site
232721002840	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
232721002841	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
232721002842	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
232721002843	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
232721002844	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
232721002845	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
232721002846	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
232721002847	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
232721002848	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
232721002849	Walker A motif; other site
232721002850	ATP binding site [chemical binding]; other site
232721002851	Walker B motif; other site
232721002852	Transposase domain (DUF772); Region: DUF772; pfam05598
232721002853	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721002854	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721002855	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
232721002856	active site
232721002857	DNA binding site [nucleotide binding]
232721002858	Int/Topo IB signature motif; other site
232721002859	Protein of unknown function DUF262; Region: DUF262; pfam03235
232721002860	Uncharacterized conserved protein [Function unknown]; Region: COG1479
232721002861	Uncharacterized conserved protein [Function unknown]; Region: COG1479
232721002862	Protein of unknown function DUF262; Region: DUF262; pfam03235
232721002863	WYL domain; Region: WYL; pfam13280
232721002864	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
232721002865	NAD-dependent deacetylase; Provisional; Region: PRK00481
232721002866	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296
232721002867	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
232721002868	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
232721002869	active site
232721002870	metal binding site [ion binding]; metal-binding site
232721002871	HNH endonuclease; Region: HNH_2; pfam13391
232721002872	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
232721002873	active site
232721002874	Predicted ATPase [General function prediction only]; Region: COG4637
232721002875	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
232721002876	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
232721002877	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721002878	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721002879	Walker A motif; other site
232721002880	ATP binding site [chemical binding]; other site
232721002881	Walker B motif; other site
232721002882	arginine finger; other site
232721002883	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721002884	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
232721002885	Integrase core domain; Region: rve; pfam00665
232721002886	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721002887	ATP binding site [chemical binding]; other site
232721002888	putative Mg++ binding site [ion binding]; other site
232721002889	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
232721002890	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721002891	ATP binding site [chemical binding]; other site
232721002892	putative Mg++ binding site [ion binding]; other site
232721002893	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721002894	ATP-binding site [chemical binding]; other site
232721002895	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
232721002896	Fic family protein [Function unknown]; Region: COG3177
232721002897	Fic/DOC family; Region: Fic; pfam02661
232721002898	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721002899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721002900	Walker A motif; other site
232721002901	ATP binding site [chemical binding]; other site
232721002902	Walker B motif; other site
232721002903	Homeodomain-like domain; Region: HTH_23; pfam13384
232721002904	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721002905	Integrase core domain; Region: rve; pfam00665
232721002906	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
232721002907	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
232721002908	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
232721002909	substrate binding pocket [chemical binding]; other site
232721002910	chain length determination region; other site
232721002911	substrate-Mg2+ binding site; other site
232721002912	catalytic residues [active]
232721002913	aspartate-rich region 1; other site
232721002914	active site lid residues [active]
232721002915	aspartate-rich region 2; other site
232721002916	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
232721002917	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
232721002918	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
232721002919	GTPase CgtA; Reviewed; Region: obgE; PRK12299
232721002920	GTP1/OBG; Region: GTP1_OBG; pfam01018
232721002921	Obg GTPase; Region: Obg; cd01898
232721002922	G1 box; other site
232721002923	GTP/Mg2+ binding site [chemical binding]; other site
232721002924	Switch I region; other site
232721002925	G2 box; other site
232721002926	G3 box; other site
232721002927	Switch II region; other site
232721002928	G4 box; other site
232721002929	G5 box; other site
232721002930	gamma-glutamyl kinase; Provisional; Region: PRK05429
232721002931	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
232721002932	nucleotide binding site [chemical binding]; other site
232721002933	homotetrameric interface [polypeptide binding]; other site
232721002934	putative phosphate binding site [ion binding]; other site
232721002935	putative allosteric binding site; other site
232721002936	PUA domain; Region: PUA; pfam01472
232721002937	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
232721002938	putative active site [active]
232721002939	Ap4A binding site [chemical binding]; other site
232721002940	nudix motif; other site
232721002941	putative metal binding site [ion binding]; other site
232721002942	prolyl-tRNA synthetase; Provisional; Region: PRK09194
232721002943	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
232721002944	dimer interface [polypeptide binding]; other site
232721002945	motif 1; other site
232721002946	active site
232721002947	motif 2; other site
232721002948	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
232721002949	putative deacylase active site [active]
232721002950	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
232721002951	active site
232721002952	motif 3; other site
232721002953	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
232721002954	anticodon binding site; other site
232721002955	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
232721002956	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721002957	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721002958	catalytic residue [active]
232721002959	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
232721002960	Domain of unknown function DUF21; Region: DUF21; pfam01595
232721002961	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
232721002962	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
232721002963	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
232721002964	putative GSH binding site [chemical binding]; other site
232721002965	catalytic residues [active]
232721002966	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
232721002967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721002968	S-adenosylmethionine binding site [chemical binding]; other site
232721002969	peptide chain release factor 1; Validated; Region: prfA; PRK00591
232721002970	This domain is found in peptide chain release factors; Region: PCRF; smart00937
232721002971	RF-1 domain; Region: RF-1; pfam00472
232721002972	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
232721002973	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
232721002974	tRNA; other site
232721002975	putative tRNA binding site [nucleotide binding]; other site
232721002976	putative NADP binding site [chemical binding]; other site
232721002977	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
232721002978	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
232721002979	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721002980	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721002981	dimerization interface [polypeptide binding]; other site
232721002982	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721002983	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
232721002984	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
232721002985	Mechanosensitive ion channel; Region: MS_channel; pfam00924
232721002986	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
232721002987	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
232721002988	putative active site [active]
232721002989	catalytic site [active]
232721002990	putative metal binding site [ion binding]; other site
232721002991	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
232721002992	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
232721002993	Walker A/P-loop; other site
232721002994	ATP binding site [chemical binding]; other site
232721002995	Q-loop/lid; other site
232721002996	ABC transporter signature motif; other site
232721002997	Walker B; other site
232721002998	D-loop; other site
232721002999	H-loop/switch region; other site
232721003000	TOBE domain; Region: TOBE_2; pfam08402
232721003001	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
232721003002	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721003003	dimer interface [polypeptide binding]; other site
232721003004	conserved gate region; other site
232721003005	putative PBP binding loops; other site
232721003006	ABC-ATPase subunit interface; other site
232721003007	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
232721003008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721003009	dimer interface [polypeptide binding]; other site
232721003010	conserved gate region; other site
232721003011	putative PBP binding loops; other site
232721003012	ABC-ATPase subunit interface; other site
232721003013	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
232721003014	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
232721003015	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
232721003016	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
232721003017	ligand binding site [chemical binding]; other site
232721003018	NAD binding site [chemical binding]; other site
232721003019	tetramer interface [polypeptide binding]; other site
232721003020	catalytic site [active]
232721003021	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
232721003022	L-serine binding site [chemical binding]; other site
232721003023	ACT domain interface; other site
232721003024	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
232721003025	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
232721003026	FAD binding domain; Region: FAD_binding_4; pfam01565
232721003027	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
232721003028	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
232721003029	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
232721003030	Cysteine-rich domain; Region: CCG; pfam02754
232721003031	Cysteine-rich domain; Region: CCG; pfam02754
232721003032	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
232721003033	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
232721003034	HIT family signature motif; other site
232721003035	catalytic residue [active]
232721003036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
232721003037	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
232721003038	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721003039	S-adenosylmethionine binding site [chemical binding]; other site
232721003040	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
232721003041	SCP-2 sterol transfer family; Region: SCP2; pfam02036
232721003042	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
232721003043	ABC1 family; Region: ABC1; pfam03109
232721003044	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
232721003045	active site
232721003046	ATP binding site [chemical binding]; other site
232721003047	Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474
232721003048	putative transporter; Provisional; Region: PRK10484
232721003049	Na binding site [ion binding]; other site
232721003050	putative glycosylation site [posttranslational modification]; other site
232721003051	putative glycosylation site [posttranslational modification]; other site
232721003052	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
232721003053	Uncharacterized conserved protein [Function unknown]; Region: COG2928
232721003054	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
232721003055	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
232721003056	dimer interface [polypeptide binding]; other site
232721003057	anticodon binding site; other site
232721003058	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
232721003059	homodimer interface [polypeptide binding]; other site
232721003060	motif 1; other site
232721003061	active site
232721003062	motif 2; other site
232721003063	GAD domain; Region: GAD; pfam02938
232721003064	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
232721003065	motif 3; other site
232721003066	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
232721003067	dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438
232721003068	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
232721003069	putative catalytic site [active]
232721003070	putative metal binding site [ion binding]; other site
232721003071	putative phosphate binding site [ion binding]; other site
232721003072	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
232721003073	PLD-like domain; Region: PLDc_2; pfam13091
232721003074	putative active site [active]
232721003075	catalytic site [active]
232721003076	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
232721003077	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
232721003078	putative active site [active]
232721003079	catalytic site [active]
232721003080	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
232721003081	active site
232721003082	Sensors of blue-light using FAD; Region: BLUF; smart01034
232721003083	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
232721003084	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
232721003085	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
232721003086	amidase; Provisional; Region: PRK07042
232721003087	Amidase; Region: Amidase; cl11426
232721003088	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
232721003089	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
232721003090	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
232721003091	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
232721003092	Walker A/P-loop; other site
232721003093	ATP binding site [chemical binding]; other site
232721003094	Q-loop/lid; other site
232721003095	ABC transporter signature motif; other site
232721003096	Walker B; other site
232721003097	D-loop; other site
232721003098	H-loop/switch region; other site
232721003099	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
232721003100	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
232721003101	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
232721003102	Walker A/P-loop; other site
232721003103	ATP binding site [chemical binding]; other site
232721003104	Q-loop/lid; other site
232721003105	ABC transporter signature motif; other site
232721003106	Walker B; other site
232721003107	D-loop; other site
232721003108	H-loop/switch region; other site
232721003109	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
232721003110	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
232721003111	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721003112	dimer interface [polypeptide binding]; other site
232721003113	conserved gate region; other site
232721003114	putative PBP binding loops; other site
232721003115	ABC-ATPase subunit interface; other site
232721003116	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
232721003117	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721003118	dimer interface [polypeptide binding]; other site
232721003119	conserved gate region; other site
232721003120	putative PBP binding loops; other site
232721003121	ABC-ATPase subunit interface; other site
232721003122	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
232721003123	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
232721003124	putative active site [active]
232721003125	catalytic residue [active]
232721003126	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
232721003127	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
232721003128	5S rRNA interface [nucleotide binding]; other site
232721003129	CTC domain interface [polypeptide binding]; other site
232721003130	L16 interface [polypeptide binding]; other site
232721003131	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
232721003132	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
232721003133	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
232721003134	active site
232721003135	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
232721003136	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
232721003137	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
232721003138	binding surface
232721003139	TPR motif; other site
232721003140	Tetratricopeptide repeat; Region: TPR_16; pfam13432
232721003141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
232721003142	binding surface
232721003143	TPR motif; other site
232721003144	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
232721003145	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
232721003146	DNA binding site [nucleotide binding]
232721003147	catalytic residue [active]
232721003148	H2TH interface [polypeptide binding]; other site
232721003149	putative catalytic residues [active]
232721003150	turnover-facilitating residue; other site
232721003151	intercalation triad [nucleotide binding]; other site
232721003152	8OG recognition residue [nucleotide binding]; other site
232721003153	putative reading head residues; other site
232721003154	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
232721003155	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
232721003156	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
232721003157	Dynamin family; Region: Dynamin_N; pfam00350
232721003158	G1 box; other site
232721003159	GTP/Mg2+ binding site [chemical binding]; other site
232721003160	G2 box; other site
232721003161	Switch I region; other site
232721003162	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
232721003163	G3 box; other site
232721003164	Switch II region; other site
232721003165	GTP/Mg2+ binding site [chemical binding]; other site
232721003166	G4 box; other site
232721003167	G5 box; other site
232721003168	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
232721003169	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
232721003170	minor groove reading motif; other site
232721003171	helix-hairpin-helix signature motif; other site
232721003172	substrate binding pocket [chemical binding]; other site
232721003173	active site
232721003174	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
232721003175	DNA binding and oxoG recognition site [nucleotide binding]
232721003176	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
232721003177	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
232721003178	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
232721003179	Walker A/P-loop; other site
232721003180	ATP binding site [chemical binding]; other site
232721003181	Q-loop/lid; other site
232721003182	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
232721003183	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
232721003184	ABC transporter signature motif; other site
232721003185	Walker B; other site
232721003186	D-loop; other site
232721003187	H-loop/switch region; other site
232721003188	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
232721003189	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
232721003190	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
232721003191	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
232721003192	Homeobox associated leucine zipper; Region: HALZ; cl02577
232721003193	Transposase; Region: HTH_Tnp_1; cl17663
232721003194	putative transposase OrfB; Reviewed; Region: PHA02517
232721003195	HTH-like domain; Region: HTH_21; pfam13276
232721003196	Integrase core domain; Region: rve; pfam00665
232721003197	Integrase core domain; Region: rve_3; cl15866
232721003198	Homeodomain-like domain; Region: HTH_23; pfam13384
232721003199	Winged helix-turn helix; Region: HTH_29; pfam13551
232721003200	Homeodomain-like domain; Region: HTH_32; pfam13565
232721003201	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721003202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721003203	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
232721003204	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
232721003205	Transposase, Mutator family; Region: Transposase_mut; pfam00872
232721003206	MULE transposase domain; Region: MULE; pfam10551
232721003207	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
232721003208	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
232721003209	catalytic triad [active]
232721003210	Isochorismatase family; Region: Isochorismatase; pfam00857
232721003211	conserved cis-peptide bond; other site
232721003212	Predicted membrane protein [Function unknown]; Region: COG2323
232721003213	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
232721003214	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
232721003215	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
232721003216	FeS/SAM binding site; other site
232721003217	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
232721003218	active site
232721003219	dimerization interface [polypeptide binding]; other site
232721003220	ribonuclease PH; Reviewed; Region: rph; PRK00173
232721003221	Ribonuclease PH; Region: RNase_PH_bact; cd11362
232721003222	hexamer interface [polypeptide binding]; other site
232721003223	active site
232721003224	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
232721003225	Protein phosphatase 2C; Region: PP2C; pfam00481
232721003226	active site
232721003227	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
232721003228	Catalytic domain of Protein Kinases; Region: PKc; cd00180
232721003229	active site
232721003230	ATP binding site [chemical binding]; other site
232721003231	substrate binding site [chemical binding]; other site
232721003232	activation loop (A-loop); other site
232721003233	hypothetical protein; Provisional; Region: PRK11820
232721003234	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
232721003235	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
232721003236	integrase; Provisional; Region: PRK09692
232721003237	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
232721003238	active site
232721003239	Int/Topo IB signature motif; other site
232721003240	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
232721003241	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
232721003242	replicative DNA helicase; Region: DnaB; TIGR00665
232721003243	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
232721003244	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
232721003245	Walker A motif; other site
232721003246	ATP binding site [chemical binding]; other site
232721003247	Walker B motif; other site
232721003248	DNA binding loops [nucleotide binding]
232721003249	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
232721003250	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721003251	non-specific DNA binding site [nucleotide binding]; other site
232721003252	salt bridge; other site
232721003253	sequence-specific DNA binding site [nucleotide binding]; other site
232721003254	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
232721003255	DNA-binding interface [nucleotide binding]; DNA binding site
232721003256	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
232721003257	Predicted transcriptional regulator [Transcription]; Region: COG2944
232721003258	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721003259	non-specific DNA binding site [nucleotide binding]; other site
232721003260	salt bridge; other site
232721003261	sequence-specific DNA binding site [nucleotide binding]; other site
232721003262	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
232721003263	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
232721003264	catalytic site [active]
232721003265	G-X2-G-X-G-K; other site
232721003266	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
232721003267	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
232721003268	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
232721003269	Zn2+ binding site [ion binding]; other site
232721003270	Mg2+ binding site [ion binding]; other site
232721003271	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
232721003272	synthetase active site [active]
232721003273	NTP binding site [chemical binding]; other site
232721003274	metal binding site [ion binding]; metal-binding site
232721003275	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
232721003276	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
232721003277	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
232721003278	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
232721003279	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
232721003280	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
232721003281	16S/18S rRNA binding site [nucleotide binding]; other site
232721003282	S13e-L30e interaction site [polypeptide binding]; other site
232721003283	25S rRNA binding site [nucleotide binding]; other site
232721003284	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
232721003285	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
232721003286	RNase E interface [polypeptide binding]; other site
232721003287	trimer interface [polypeptide binding]; other site
232721003288	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
232721003289	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
232721003290	RNase E interface [polypeptide binding]; other site
232721003291	trimer interface [polypeptide binding]; other site
232721003292	active site
232721003293	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
232721003294	putative nucleic acid binding region [nucleotide binding]; other site
232721003295	G-X-X-G motif; other site
232721003296	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
232721003297	RNA binding site [nucleotide binding]; other site
232721003298	domain interface; other site
232721003299	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
232721003300	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
232721003301	NAD(P) binding site [chemical binding]; other site
232721003302	triosephosphate isomerase; Provisional; Region: PRK14567
232721003303	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
232721003304	substrate binding site [chemical binding]; other site
232721003305	dimer interface [polypeptide binding]; other site
232721003306	catalytic triad [active]
232721003307	Preprotein translocase SecG subunit; Region: SecG; pfam03840
232721003308	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
232721003309	NADH dehydrogenase subunit B; Validated; Region: PRK06411
232721003310	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
232721003311	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
232721003312	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
232721003313	NADH dehydrogenase subunit D; Validated; Region: PRK06075
232721003314	NADH dehydrogenase subunit E; Validated; Region: PRK07539
232721003315	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
232721003316	putative dimer interface [polypeptide binding]; other site
232721003317	[2Fe-2S] cluster binding site [ion binding]; other site
232721003318	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
232721003319	SLBB domain; Region: SLBB; pfam10531
232721003320	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
232721003321	NADH dehydrogenase subunit G; Validated; Region: PRK09129
232721003322	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
232721003323	catalytic loop [active]
232721003324	iron binding site [ion binding]; other site
232721003325	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
232721003326	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
232721003327	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
232721003328	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
232721003329	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
232721003330	4Fe-4S binding domain; Region: Fer4; pfam00037
232721003331	4Fe-4S binding domain; Region: Fer4; pfam00037
232721003332	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
232721003333	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
232721003334	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
232721003335	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
232721003336	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
232721003337	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
232721003338	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
232721003339	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
232721003340	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
232721003341	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
232721003342	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
232721003343	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
232721003344	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
232721003345	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
232721003346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721003347	Walker A/P-loop; other site
232721003348	ATP binding site [chemical binding]; other site
232721003349	Q-loop/lid; other site
232721003350	ABC transporter signature motif; other site
232721003351	Walker B; other site
232721003352	D-loop; other site
232721003353	H-loop/switch region; other site
232721003354	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721003355	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
232721003356	Walker A/P-loop; other site
232721003357	ATP binding site [chemical binding]; other site
232721003358	Q-loop/lid; other site
232721003359	ABC transporter signature motif; other site
232721003360	D-loop; other site
232721003361	H-loop/switch region; other site
232721003362	LysE type translocator; Region: LysE; cl00565
232721003363	glutamate dehydrogenase; Provisional; Region: PRK09414
232721003364	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
232721003365	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
232721003366	NAD(P) binding site [chemical binding]; other site
232721003367	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
232721003368	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721003369	ATP binding site [chemical binding]; other site
232721003370	Mg2+ binding site [ion binding]; other site
232721003371	G-X-G motif; other site
232721003372	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
232721003373	ATP binding site [chemical binding]; other site
232721003374	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
232721003375	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
232721003376	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
232721003377	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
232721003378	AMIN domain; Region: AMIN; pfam11741
232721003379	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
232721003380	active site
232721003381	metal binding site [ion binding]; metal-binding site
232721003382	epoxyqueuosine reductase; Region: TIGR00276
232721003383	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
232721003384	Membrane transport protein; Region: Mem_trans; cl09117
232721003385	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721003386	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
232721003387	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
232721003388	active site
232721003389	Int/Topo IB signature motif; other site
232721003390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
232721003391	EAL domain; Region: EAL; pfam00563
232721003392	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
232721003393	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
232721003394	EAL domain; Region: EAL; pfam00563
232721003395	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
232721003396	dinuclear metal binding motif [ion binding]; other site
232721003397	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
232721003398	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
232721003399	trimer interface [polypeptide binding]; other site
232721003400	putative metal binding site [ion binding]; other site
232721003401	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
232721003402	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
232721003403	dimerization interface [polypeptide binding]; other site
232721003404	domain crossover interface; other site
232721003405	redox-dependent activation switch; other site
232721003406	Septum formation initiator; Region: DivIC; cl17659
232721003407	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
232721003408	enolase; Provisional; Region: eno; PRK00077
232721003409	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
232721003410	dimer interface [polypeptide binding]; other site
232721003411	metal binding site [ion binding]; metal-binding site
232721003412	substrate binding pocket [chemical binding]; other site
232721003413	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
232721003414	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
232721003415	CTP synthetase; Validated; Region: pyrG; PRK05380
232721003416	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
232721003417	Catalytic site [active]
232721003418	active site
232721003419	UTP binding site [chemical binding]; other site
232721003420	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
232721003421	active site
232721003422	putative oxyanion hole; other site
232721003423	catalytic triad [active]
232721003424	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
232721003425	Flavoprotein; Region: Flavoprotein; pfam02441
232721003426	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
232721003427	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
232721003428	trimer interface [polypeptide binding]; other site
232721003429	active site
232721003430	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
232721003431	Uncharacterized conserved protein [Function unknown]; Region: COG2850
232721003432	Cupin-like domain; Region: Cupin_8; pfam13621
232721003433	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
232721003434	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
232721003435	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
232721003436	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
232721003437	dihydrodipicolinate synthase; Region: dapA; TIGR00674
232721003438	dimer interface [polypeptide binding]; other site
232721003439	active site
232721003440	catalytic residue [active]
232721003441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721003442	S-adenosylmethionine binding site [chemical binding]; other site
232721003443	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721003444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721003445	putative substrate translocation pore; other site
232721003446	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
232721003447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721003448	ATP binding site [chemical binding]; other site
232721003449	Mg2+ binding site [ion binding]; other site
232721003450	G-X-G motif; other site
232721003451	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
232721003452	anchoring element; other site
232721003453	dimer interface [polypeptide binding]; other site
232721003454	ATP binding site [chemical binding]; other site
232721003455	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
232721003456	active site
232721003457	metal binding site [ion binding]; metal-binding site
232721003458	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
232721003459	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
232721003460	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
232721003461	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721003462	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721003463	catalytic residue [active]
232721003464	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
232721003465	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
232721003466	CAP-like domain; other site
232721003467	active site
232721003468	primary dimer interface [polypeptide binding]; other site
232721003469	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
232721003470	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
232721003471	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721003472	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721003473	dimer interface [polypeptide binding]; other site
232721003474	putative CheW interface [polypeptide binding]; other site
232721003475	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
232721003476	homotrimer interaction site [polypeptide binding]; other site
232721003477	putative active site [active]
232721003478	Uncharacterized conserved protein [Function unknown]; Region: COG2308
232721003479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
232721003480	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
232721003481	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
232721003482	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721003483	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721003484	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
232721003485	putative effector binding pocket; other site
232721003486	putative dimerization interface [polypeptide binding]; other site
232721003487	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
232721003488	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
232721003489	tetramerization interface [polypeptide binding]; other site
232721003490	NAD(P) binding site [chemical binding]; other site
232721003491	catalytic residues [active]
232721003492	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
232721003493	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
232721003494	N-terminal plug; other site
232721003495	ligand-binding site [chemical binding]; other site
232721003496	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
232721003497	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
232721003498	N-terminal plug; other site
232721003499	ligand-binding site [chemical binding]; other site
232721003500	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
232721003501	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
232721003502	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
232721003503	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
232721003504	active site residue [active]
232721003505	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
232721003506	active site residue [active]
232721003507	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
232721003508	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
232721003509	[2Fe-2S] cluster binding site [ion binding]; other site
232721003510	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
232721003511	alpha subunit interface [polypeptide binding]; other site
232721003512	active site
232721003513	substrate binding site [chemical binding]; other site
232721003514	Fe binding site [ion binding]; other site
232721003515	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
232721003516	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
232721003517	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
232721003518	substrate binding pocket [chemical binding]; other site
232721003519	chain length determination region; other site
232721003520	substrate-Mg2+ binding site; other site
232721003521	catalytic residues [active]
232721003522	aspartate-rich region 1; other site
232721003523	active site lid residues [active]
232721003524	aspartate-rich region 2; other site
232721003525	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
232721003526	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
232721003527	TPP-binding site; other site
232721003528	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
232721003529	PYR/PP interface [polypeptide binding]; other site
232721003530	dimer interface [polypeptide binding]; other site
232721003531	TPP binding site [chemical binding]; other site
232721003532	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
232721003533	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
232721003534	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
232721003535	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
232721003536	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
232721003537	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
232721003538	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
232721003539	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
232721003540	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721003541	active site
232721003542	phosphorylation site [posttranslational modification]
232721003543	intermolecular recognition site; other site
232721003544	dimerization interface [polypeptide binding]; other site
232721003545	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
232721003546	Zn2+ binding site [ion binding]; other site
232721003547	Mg2+ binding site [ion binding]; other site
232721003548	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
232721003549	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
232721003550	active site
232721003551	dimerization interface [polypeptide binding]; other site
232721003552	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
232721003553	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
232721003554	serine O-acetyltransferase; Region: cysE; TIGR01172
232721003555	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
232721003556	trimer interface [polypeptide binding]; other site
232721003557	active site
232721003558	substrate binding site [chemical binding]; other site
232721003559	CoA binding site [chemical binding]; other site
232721003560	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
232721003561	putative FMN binding site [chemical binding]; other site
232721003562	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
232721003563	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
232721003564	tetramer interface [polypeptide binding]; other site
232721003565	catalytic Zn binding site [ion binding]; other site
232721003566	NADP binding site [chemical binding]; other site
232721003567	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
232721003568	Sulfate transporter family; Region: Sulfate_transp; pfam00916
232721003569	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
232721003570	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
232721003571	MPT binding site; other site
232721003572	trimer interface [polypeptide binding]; other site
232721003573	Protein of unknown function (DUF615); Region: DUF615; pfam04751
232721003574	peptidase PmbA; Provisional; Region: PRK11040
232721003575	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
232721003576	EamA-like transporter family; Region: EamA; pfam00892
232721003577	tellurium resistance terB-like protein; Region: terB_like; cd07177
232721003578	metal binding site [ion binding]; metal-binding site
232721003579	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
232721003580	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
232721003581	Fumarase C-terminus; Region: Fumerase_C; pfam05683
232721003582	fumarate hydratase; Reviewed; Region: fumC; PRK00485
232721003583	Class II fumarases; Region: Fumarase_classII; cd01362
232721003584	active site
232721003585	tetramer interface [polypeptide binding]; other site
232721003586	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
232721003587	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
232721003588	ligand binding site [chemical binding]; other site
232721003589	flexible hinge region; other site
232721003590	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
232721003591	non-specific DNA interactions [nucleotide binding]; other site
232721003592	DNA binding site [nucleotide binding]
232721003593	sequence specific DNA binding site [nucleotide binding]; other site
232721003594	putative cAMP binding site [chemical binding]; other site
232721003595	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
232721003596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721003597	active site
232721003598	phosphorylation site [posttranslational modification]
232721003599	intermolecular recognition site; other site
232721003600	dimerization interface [polypeptide binding]; other site
232721003601	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721003602	DNA binding site [nucleotide binding]
232721003603	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
232721003604	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721003605	dimerization interface [polypeptide binding]; other site
232721003606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721003607	dimer interface [polypeptide binding]; other site
232721003608	phosphorylation site [posttranslational modification]
232721003609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721003610	ATP binding site [chemical binding]; other site
232721003611	Mg2+ binding site [ion binding]; other site
232721003612	G-X-G motif; other site
232721003613	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
232721003614	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
232721003615	Homeodomain-like domain; Region: HTH_23; pfam13384
232721003616	Winged helix-turn helix; Region: HTH_29; pfam13551
232721003617	Homeodomain-like domain; Region: HTH_32; pfam13565
232721003618	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721003619	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721003620	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
232721003621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721003622	dimer interface [polypeptide binding]; other site
232721003623	conserved gate region; other site
232721003624	putative PBP binding loops; other site
232721003625	ABC-ATPase subunit interface; other site
232721003626	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
232721003627	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
232721003628	Walker A/P-loop; other site
232721003629	ATP binding site [chemical binding]; other site
232721003630	Q-loop/lid; other site
232721003631	ABC transporter signature motif; other site
232721003632	Walker B; other site
232721003633	D-loop; other site
232721003634	H-loop/switch region; other site
232721003635	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
232721003636	hypothetical protein; Provisional; Region: PRK05208
232721003637	acetyl-CoA synthetase; Provisional; Region: PRK00174
232721003638	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
232721003639	active site
232721003640	CoA binding site [chemical binding]; other site
232721003641	acyl-activating enzyme (AAE) consensus motif; other site
232721003642	AMP binding site [chemical binding]; other site
232721003643	acetate binding site [chemical binding]; other site
232721003644	Cytochrome c; Region: Cytochrom_C; cl11414
232721003645	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
232721003646	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
232721003647	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
232721003648	CoenzymeA binding site [chemical binding]; other site
232721003649	subunit interaction site [polypeptide binding]; other site
232721003650	PHB binding site; other site
232721003651	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
232721003652	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
232721003653	heme binding site [chemical binding]; other site
232721003654	ferroxidase pore; other site
232721003655	ferroxidase diiron center [ion binding]; other site
232721003656	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
232721003657	Transcriptional regulators [Transcription]; Region: GntR; COG1802
232721003658	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
232721003659	DNA-binding site [nucleotide binding]; DNA binding site
232721003660	FCD domain; Region: FCD; pfam07729
232721003661	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
232721003662	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721003663	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
232721003664	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721003665	substrate binding site [chemical binding]; other site
232721003666	oxyanion hole (OAH) forming residues; other site
232721003667	trimer interface [polypeptide binding]; other site
232721003668	malonyl-CoA synthase; Validated; Region: PRK07514
232721003669	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
232721003670	acyl-activating enzyme (AAE) consensus motif; other site
232721003671	active site
232721003672	AMP binding site [chemical binding]; other site
232721003673	CoA binding site [chemical binding]; other site
232721003674	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
232721003675	Ligand Binding Site [chemical binding]; other site
232721003676	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
232721003677	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721003678	metal-binding site [ion binding]
232721003679	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721003680	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
232721003681	Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197
232721003682	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
232721003683	Low-spin heme binding site [chemical binding]; other site
232721003684	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
232721003685	Putative water exit pathway; other site
232721003686	Binuclear center (active site) [active]
232721003687	Putative proton exit pathway; other site
232721003688	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
232721003689	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
232721003690	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
232721003691	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
232721003692	Cytochrome c; Region: Cytochrom_C; pfam00034
232721003693	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
232721003694	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
232721003695	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
232721003696	FixH; Region: FixH; pfam05751
232721003697	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
232721003698	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
232721003699	ligand binding site [chemical binding]; other site
232721003700	flexible hinge region; other site
232721003701	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
232721003702	putative switch regulator; other site
232721003703	non-specific DNA interactions [nucleotide binding]; other site
232721003704	DNA binding site [nucleotide binding]
232721003705	sequence specific DNA binding site [nucleotide binding]; other site
232721003706	putative cAMP binding site [chemical binding]; other site
232721003707	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
232721003708	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
232721003709	FeS/SAM binding site; other site
232721003710	HemN C-terminal domain; Region: HemN_C; pfam06969
232721003711	Family description; Region: DsbD_2; pfam13386
232721003712	Cell division protein ZapA; Region: ZapA; pfam05164
232721003713	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
232721003714	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
232721003715	N-terminal plug; other site
232721003716	ligand-binding site [chemical binding]; other site
232721003717	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
232721003718	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
232721003719	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
232721003720	catalytic triad [active]
232721003721	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
232721003722	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
232721003723	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
232721003724	intersubunit interface [polypeptide binding]; other site
232721003725	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
232721003726	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
232721003727	dimer interface [polypeptide binding]; other site
232721003728	putative PBP binding regions; other site
232721003729	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
232721003730	ABC-ATPase subunit  interface; other site
232721003731	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
232721003732	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
232721003733	Walker A/P-loop; other site
232721003734	ATP binding site [chemical binding]; other site
232721003735	Q-loop/lid; other site
232721003736	ABC transporter signature motif; other site
232721003737	Walker B; other site
232721003738	D-loop; other site
232721003739	H-loop/switch region; other site
232721003740	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
232721003741	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
232721003742	homodimer interface [polypeptide binding]; other site
232721003743	Walker A motif; other site
232721003744	ATP binding site [chemical binding]; other site
232721003745	hydroxycobalamin binding site [chemical binding]; other site
232721003746	Walker B motif; other site
232721003747	Protein of unknown function (DUF3334); Region: DUF3334; pfam11813
232721003748	Transposase, Mutator family; Region: Transposase_mut; pfam00872
232721003749	MULE transposase domain; Region: MULE; pfam10551
232721003750	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
232721003751	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721003752	motif II; other site
232721003753	MFS transport protein AraJ; Provisional; Region: PRK10091
232721003754	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721003755	putative substrate translocation pore; other site
232721003756	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
232721003757	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
232721003758	malic enzyme; Reviewed; Region: PRK12862
232721003759	Malic enzyme, N-terminal domain; Region: malic; pfam00390
232721003760	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
232721003761	putative NAD(P) binding site [chemical binding]; other site
232721003762	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
232721003763	xanthine permease; Region: pbuX; TIGR03173
232721003764	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651
232721003765	M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697
232721003766	putative metal binding site [ion binding]; other site
232721003767	putative bifunctional OHCU decarboxylase/allantoate amidohydrolase; Provisional; Region: PRK13590
232721003768	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
232721003769	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
232721003770	active site
232721003771	metal binding site [ion binding]; metal-binding site
232721003772	dimer interface [polypeptide binding]; other site
232721003773	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
232721003774	Transposase; Region: DDE_Tnp_ISL3; pfam01610
232721003775	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
232721003776	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
232721003777	active site
232721003778	catalytic site [active]
232721003779	tetramer interface [polypeptide binding]; other site
232721003780	Transcriptional regulators [Transcription]; Region: GntR; COG1802
232721003781	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
232721003782	DNA-binding site [nucleotide binding]; DNA binding site
232721003783	FCD domain; Region: FCD; pfam07729
232721003784	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721003785	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721003786	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
232721003787	putative effector binding pocket; other site
232721003788	putative dimerization interface [polypeptide binding]; other site
232721003789	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
232721003790	tartrate dehydrogenase; Region: TTC; TIGR02089
232721003791	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721003792	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
232721003793	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
232721003794	MOFRL family; Region: MOFRL; pfam05161
232721003795	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
232721003796	active site
232721003797	homotetramer interface [polypeptide binding]; other site
232721003798	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
232721003799	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
232721003800	XdhC Rossmann domain; Region: XdhC_C; pfam13478
232721003801	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
232721003802	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
232721003803	NAD(P) binding site [chemical binding]; other site
232721003804	catalytic residues [active]
232721003805	Transcriptional regulators [Transcription]; Region: GntR; COG1802
232721003806	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
232721003807	FCD domain; Region: FCD; pfam07729
232721003808	Predicted membrane protein [Function unknown]; Region: COG3748
232721003809	Protein of unknown function (DUF989); Region: DUF989; pfam06181
232721003810	Cytochrome c; Region: Cytochrom_C; pfam00034
232721003811	guanine deaminase; Provisional; Region: PRK09228
232721003812	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
232721003813	active site
232721003814	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
232721003815	trimer interface [polypeptide binding]; other site
232721003816	active site
232721003817	Predicted metalloprotease [General function prediction only]; Region: COG2321
232721003818	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
232721003819	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
232721003820	DEAD-like helicases superfamily; Region: DEXDc; smart00487
232721003821	ATP binding site [chemical binding]; other site
232721003822	Mg++ binding site [ion binding]; other site
232721003823	motif III; other site
232721003824	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721003825	nucleotide binding region [chemical binding]; other site
232721003826	ATP-binding site [chemical binding]; other site
232721003827	NosL; Region: NosL; cl01769
232721003828	NosL; Region: NosL; pfam05573
232721003829	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
232721003830	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
232721003831	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
232721003832	Walker A/P-loop; other site
232721003833	ATP binding site [chemical binding]; other site
232721003834	Q-loop/lid; other site
232721003835	ABC transporter signature motif; other site
232721003836	Walker B; other site
232721003837	D-loop; other site
232721003838	H-loop/switch region; other site
232721003839	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
232721003840	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
232721003841	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
232721003842	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
232721003843	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
232721003844	4Fe-4S binding domain; Region: Fer4_5; pfam12801
232721003845	4Fe-4S binding domain; Region: Fer4_5; pfam12801
232721003846	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
232721003847	nitrous-oxide reductase; Validated; Region: PRK02888
232721003848	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
232721003849	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
232721003850	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
232721003851	ApbE family; Region: ApbE; pfam02424
232721003852	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
232721003853	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
232721003854	active site
232721003855	metal binding site [ion binding]; metal-binding site
232721003856	H-NS histone family; Region: Histone_HNS; pfam00816
232721003857	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
232721003858	aconitate hydratase; Validated; Region: PRK09277
232721003859	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
232721003860	substrate binding site [chemical binding]; other site
232721003861	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
232721003862	ligand binding site [chemical binding]; other site
232721003863	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
232721003864	substrate binding site [chemical binding]; other site
232721003865	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
232721003866	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
232721003867	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721003868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721003869	putative substrate translocation pore; other site
232721003870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721003871	active site
232721003872	phosphorylation site [posttranslational modification]
232721003873	intermolecular recognition site; other site
232721003874	dimerization interface [polypeptide binding]; other site
232721003875	LytTr DNA-binding domain; Region: LytTR; smart00850
232721003876	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721003877	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721003878	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721003879	Histidine kinase; Region: His_kinase; pfam06580
232721003880	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
232721003881	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
232721003882	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
232721003883	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721003884	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721003885	metal binding site [ion binding]; metal-binding site
232721003886	active site
232721003887	I-site; other site
232721003888	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
232721003889	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
232721003890	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
232721003891	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
232721003892	PhoD-like phosphatase; Region: PhoD; pfam09423
232721003893	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
232721003894	putative active site [active]
232721003895	putative metal binding site [ion binding]; other site
232721003896	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
232721003897	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721003898	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721003899	metal binding site [ion binding]; metal-binding site
232721003900	active site
232721003901	I-site; other site
232721003902	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
232721003903	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
232721003904	NAD(P) binding site [chemical binding]; other site
232721003905	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
232721003906	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
232721003907	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721003908	S-adenosylmethionine binding site [chemical binding]; other site
232721003909	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
232721003910	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
232721003911	Peptidase family M23; Region: Peptidase_M23; pfam01551
232721003912	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
232721003913	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
232721003914	RNA binding surface [nucleotide binding]; other site
232721003915	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
232721003916	active site
232721003917	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
232721003918	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
232721003919	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
232721003920	RNA binding surface [nucleotide binding]; other site
232721003921	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
232721003922	probable active site [active]
232721003923	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
232721003924	active site
232721003925	multimer interface [polypeptide binding]; other site
232721003926	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
232721003927	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
232721003928	FeS/SAM binding site; other site
232721003929	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
232721003930	binding surface
232721003931	TPR motif; other site
232721003932	Tetratricopeptide repeat; Region: TPR_12; pfam13424
232721003933	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
232721003934	binding surface
232721003935	TPR motif; other site
232721003936	TPR repeat; Region: TPR_11; pfam13414
232721003937	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
232721003938	Helix-turn-helix domain; Region: HTH_25; pfam13413
232721003939	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
232721003940	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
232721003941	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
232721003942	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
232721003943	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
232721003944	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
232721003945	dimer interface [polypeptide binding]; other site
232721003946	motif 1; other site
232721003947	active site
232721003948	motif 2; other site
232721003949	motif 3; other site
232721003950	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
232721003951	anticodon binding site; other site
232721003952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
232721003953	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
232721003954	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
232721003955	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
232721003956	Trp docking motif [polypeptide binding]; other site
232721003957	active site
232721003958	GTP-binding protein Der; Reviewed; Region: PRK00093
232721003959	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
232721003960	G1 box; other site
232721003961	GTP/Mg2+ binding site [chemical binding]; other site
232721003962	Switch I region; other site
232721003963	G2 box; other site
232721003964	Switch II region; other site
232721003965	G3 box; other site
232721003966	G4 box; other site
232721003967	G5 box; other site
232721003968	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
232721003969	G1 box; other site
232721003970	GTP/Mg2+ binding site [chemical binding]; other site
232721003971	Switch I region; other site
232721003972	G2 box; other site
232721003973	G3 box; other site
232721003974	Switch II region; other site
232721003975	G4 box; other site
232721003976	G5 box; other site
232721003977	bacterial Hfq-like; Region: Hfq; cd01716
232721003978	hexamer interface [polypeptide binding]; other site
232721003979	Sm1 motif; other site
232721003980	RNA binding site [nucleotide binding]; other site
232721003981	Sm2 motif; other site
232721003982	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
232721003983	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
232721003984	HflX GTPase family; Region: HflX; cd01878
232721003985	G1 box; other site
232721003986	GTP/Mg2+ binding site [chemical binding]; other site
232721003987	Switch I region; other site
232721003988	G2 box; other site
232721003989	G3 box; other site
232721003990	Switch II region; other site
232721003991	G4 box; other site
232721003992	G5 box; other site
232721003993	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
232721003994	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
232721003995	HflK protein; Region: hflK; TIGR01933
232721003996	HflC protein; Region: hflC; TIGR01932
232721003997	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
232721003998	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
232721003999	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
232721004000	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
232721004001	dimer interface [polypeptide binding]; other site
232721004002	motif 1; other site
232721004003	active site
232721004004	motif 2; other site
232721004005	motif 3; other site
232721004006	adenylosuccinate synthetase; Provisional; Region: PRK01117
232721004007	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
232721004008	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
232721004009	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
232721004010	active site
232721004011	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
232721004012	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
232721004013	active site
232721004014	uracil binding [chemical binding]; other site
232721004015	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
232721004016	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
232721004017	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
232721004018	NodB motif; other site
232721004019	active site
232721004020	catalytic site [active]
232721004021	metal binding site [ion binding]; metal-binding site
232721004022	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
232721004023	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
232721004024	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
232721004025	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
232721004026	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
232721004027	putative MPT binding site; other site
232721004028	glutamine synthetase; Provisional; Region: glnA; PRK09469
232721004029	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
232721004030	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
232721004031	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
232721004032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721004033	dimer interface [polypeptide binding]; other site
232721004034	phosphorylation site [posttranslational modification]
232721004035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721004036	ATP binding site [chemical binding]; other site
232721004037	Mg2+ binding site [ion binding]; other site
232721004038	G-X-G motif; other site
232721004039	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
232721004040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721004041	active site
232721004042	phosphorylation site [posttranslational modification]
232721004043	intermolecular recognition site; other site
232721004044	dimerization interface [polypeptide binding]; other site
232721004045	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721004046	Walker A motif; other site
232721004047	ATP binding site [chemical binding]; other site
232721004048	Walker B motif; other site
232721004049	arginine finger; other site
232721004050	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
232721004051	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
232721004052	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
232721004053	putative catalytic site [active]
232721004054	putative phosphate binding site [ion binding]; other site
232721004055	active site
232721004056	metal binding site A [ion binding]; metal-binding site
232721004057	DNA binding site [nucleotide binding]
232721004058	putative AP binding site [nucleotide binding]; other site
232721004059	putative metal binding site B [ion binding]; other site
232721004060	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
232721004061	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
232721004062	folate binding site [chemical binding]; other site
232721004063	NADP+ binding site [chemical binding]; other site
232721004064	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
232721004065	PLD-like domain; Region: PLDc_2; pfam13091
232721004066	putative homodimer interface [polypeptide binding]; other site
232721004067	putative active site [active]
232721004068	catalytic site [active]
232721004069	thymidylate synthase; Reviewed; Region: thyA; PRK01827
232721004070	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
232721004071	dimerization interface [polypeptide binding]; other site
232721004072	active site
232721004073	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
232721004074	FAD binding domain; Region: FAD_binding_4; pfam01565
232721004075	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
232721004076	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
232721004077	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
232721004078	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
232721004079	catalytic residues [active]
232721004080	substrate binding pocket [chemical binding]; other site
232721004081	substrate-Mg2+ binding site; other site
232721004082	aspartate-rich region 1; other site
232721004083	aspartate-rich region 2; other site
232721004084	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
232721004085	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
232721004086	putative active site [active]
232721004087	putative metal binding site [ion binding]; other site
232721004088	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
232721004089	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
232721004090	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
232721004091	active site lid residues [active]
232721004092	substrate binding pocket [chemical binding]; other site
232721004093	catalytic residues [active]
232721004094	substrate-Mg2+ binding site; other site
232721004095	aspartate-rich region 1; other site
232721004096	aspartate-rich region 2; other site
232721004097	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
232721004098	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
232721004099	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721004100	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
232721004101	trigger factor; Provisional; Region: tig; PRK01490
232721004102	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
232721004103	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
232721004104	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
232721004105	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
232721004106	oligomer interface [polypeptide binding]; other site
232721004107	active site residues [active]
232721004108	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
232721004109	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
232721004110	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721004111	Walker A motif; other site
232721004112	ATP binding site [chemical binding]; other site
232721004113	Walker B motif; other site
232721004114	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
232721004115	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
232721004116	Found in ATP-dependent protease La (LON); Region: LON; smart00464
232721004117	Found in ATP-dependent protease La (LON); Region: LON; smart00464
232721004118	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721004119	Walker A motif; other site
232721004120	ATP binding site [chemical binding]; other site
232721004121	Walker B motif; other site
232721004122	arginine finger; other site
232721004123	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
232721004124	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
232721004125	active site
232721004126	Int/Topo IB signature motif; other site
232721004127	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721004128	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
232721004129	Integrase core domain; Region: rve; pfam00665
232721004130	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721004131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721004132	Walker A motif; other site
232721004133	ATP binding site [chemical binding]; other site
232721004134	Walker B motif; other site
232721004135	arginine finger; other site
232721004136	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721004137	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721004138	Walker A motif; other site
232721004139	ATP binding site [chemical binding]; other site
232721004140	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
232721004141	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
232721004142	conserved cys residue [active]
232721004143	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
232721004144	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
232721004145	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721004146	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
232721004147	dimerization interface [polypeptide binding]; other site
232721004148	substrate binding pocket [chemical binding]; other site
232721004149	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
232721004150	Integrase core domain; Region: rve; pfam00665
232721004151	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
232721004152	Bacterial TniB protein; Region: TniB; pfam05621
232721004153	AAA domain; Region: AAA_22; pfam13401
232721004154	TniQ; Region: TniQ; pfam06527
232721004155	Helix-turn-helix domain; Region: HTH_28; pfam13518
232721004156	Winged helix-turn helix; Region: HTH_29; pfam13551
232721004157	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721004158	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721004159	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721004160	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
232721004161	Transposase; Region: DDE_Tnp_ISL3; pfam01610
232721004162	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721004163	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
232721004164	dimerization interface [polypeptide binding]; other site
232721004165	substrate binding pocket [chemical binding]; other site
232721004166	Transposase domain (DUF772); Region: DUF772; pfam05598
232721004167	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721004168	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721004169	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721004170	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
232721004171	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
232721004172	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
232721004173	Multicopper oxidase; Region: Cu-oxidase; pfam00394
232721004174	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
232721004175	DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836
232721004176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721004177	active site
232721004178	phosphorylation site [posttranslational modification]
232721004179	intermolecular recognition site; other site
232721004180	dimerization interface [polypeptide binding]; other site
232721004181	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721004182	DNA binding site [nucleotide binding]
232721004183	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
232721004184	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
232721004185	DNA-binding interface [nucleotide binding]; DNA binding site
232721004186	Homeodomain-like domain; Region: HTH_32; pfam13565
232721004187	Integrase core domain; Region: rve; pfam00665
232721004188	HTH-like domain; Region: HTH_21; pfam13276
232721004189	Cytochrome c; Region: Cytochrom_C; pfam00034
232721004190	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
232721004191	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
232721004192	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
232721004193	DNA binding residues [nucleotide binding]
232721004194	dimer interface [polypeptide binding]; other site
232721004195	putative metal binding site [ion binding]; other site
232721004196	Heavy-metal-associated domain; Region: HMA; pfam00403
232721004197	metal-binding site [ion binding]
232721004198	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
232721004199	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004200	metal-binding site [ion binding]
232721004201	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721004202	Soluble P-type ATPase [General function prediction only]; Region: COG4087
232721004203	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
232721004204	active site
232721004205	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
232721004206	lipoprotein signal peptidase; Provisional; Region: PRK14787
232721004207	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
232721004208	Putative helicase; Region: TraI_2; pfam07514
232721004209	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
232721004210	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
232721004211	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
232721004212	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
232721004213	Protein of unknown function (DUF3742); Region: DUF3742; pfam12553
232721004214	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
232721004215	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
232721004216	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
232721004217	integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757
232721004218	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
232721004219	MPN+ (JAMM) motif; other site
232721004220	Zinc-binding site [ion binding]; other site
232721004221	Thioredoxin; Region: Thioredoxin_4; cl17273
232721004222	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
232721004223	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
232721004224	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
232721004225	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
232721004226	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
232721004227	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
232721004228	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
232721004229	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
232721004230	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
232721004231	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
232721004232	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
232721004233	DNA binding domain, excisionase family; Region: excise; TIGR01764
232721004234	PIN domain; Region: PIN_3; pfam13470
232721004235	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
232721004236	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721004237	Walker A motif; other site
232721004238	ATP binding site [chemical binding]; other site
232721004239	Walker B motif; other site
232721004240	arginine finger; other site
232721004241	HORMA domain; Region: HORMA; pfam02301
232721004242	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
232721004243	active site
232721004244	NTP binding site [chemical binding]; other site
232721004245	metal binding triad [ion binding]; metal-binding site
232721004246	AAA domain; Region: AAA_23; pfam13476
232721004247	P-loop containing region of AAA domain; Region: AAA_29; cl17516
232721004248	AAA domain; Region: AAA_21; pfam13304
232721004249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721004250	ABC transporter signature motif; other site
232721004251	Walker B; other site
232721004252	D-loop; other site
232721004253	H-loop/switch region; other site
232721004254	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
232721004255	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
232721004256	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
232721004257	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
232721004258	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721004259	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721004260	catalytic residue [active]
232721004261	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
232721004262	PemK-like protein; Region: PemK; cl00995
232721004263	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
232721004264	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721004265	dimerization interface [polypeptide binding]; other site
232721004266	putative DNA binding site [nucleotide binding]; other site
232721004267	putative Zn2+ binding site [ion binding]; other site
232721004268	Low molecular weight phosphatase family; Region: LMWPc; cd00115
232721004269	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
232721004270	active site
232721004271	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
232721004272	arsenical-resistance protein; Region: acr3; TIGR00832
232721004273	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
232721004274	ArsC family; Region: ArsC; pfam03960
232721004275	catalytic residues [active]
232721004276	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
232721004277	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
232721004278	DEAD-like helicases superfamily; Region: DEXDc; smart00487
232721004279	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721004280	nucleotide binding region [chemical binding]; other site
232721004281	ATP-binding site [chemical binding]; other site
232721004282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721004283	S-adenosylmethionine binding site [chemical binding]; other site
232721004284	Protein of unknown function (DUF3275); Region: DUF3275; pfam11679
232721004285	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
232721004286	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
232721004287	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
232721004288	putative mercuric reductase; Provisional; Region: PRK13748
232721004289	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004290	metal-binding site [ion binding]
232721004291	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
232721004292	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721004293	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
232721004294	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004295	metal-binding site [ion binding]
232721004296	putative mercuric transport protein; Provisional; Region: PRK13751
232721004297	putative transcriptional regulator MerR; Provisional; Region: PRK13752
232721004298	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
232721004299	DNA binding residues [nucleotide binding]
232721004300	dimer interface [polypeptide binding]; other site
232721004301	mercury binding site [ion binding]; other site
232721004302	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
232721004303	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
232721004304	cofactor binding site; other site
232721004305	DNA binding site [nucleotide binding]
232721004306	substrate interaction site [chemical binding]; other site
232721004307	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
232721004308	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
232721004309	DNA topoisomerase III; Provisional; Region: PRK07726
232721004310	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
232721004311	active site
232721004312	putative interdomain interaction site [polypeptide binding]; other site
232721004313	putative metal-binding site [ion binding]; other site
232721004314	putative nucleotide binding site [chemical binding]; other site
232721004315	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
232721004316	domain I; other site
232721004317	DNA binding groove [nucleotide binding]
232721004318	phosphate binding site [ion binding]; other site
232721004319	domain II; other site
232721004320	domain III; other site
232721004321	nucleotide binding site [chemical binding]; other site
232721004322	catalytic site [active]
232721004323	domain IV; other site
232721004324	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
232721004325	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
232721004326	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
232721004327	ssDNA binding site [nucleotide binding]; other site
232721004328	dimer interface [polypeptide binding]; other site
232721004329	tetramer (dimer of dimers) interface [polypeptide binding]; other site
232721004330	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
232721004331	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
232721004332	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
232721004333	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
232721004334	ParB-like nuclease domain; Region: ParBc; pfam02195
232721004335	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
232721004336	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721004337	Magnesium ion binding site [ion binding]; other site
232721004338	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
232721004339	Domain of unknown function (DUF305); Region: DUF305; cl17794
232721004340	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
232721004341	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
232721004342	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
232721004343	hypothetical protein; Provisional; Region: PRK02237
232721004344	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
232721004345	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
232721004346	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
232721004347	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721004348	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
232721004349	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
232721004350	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
232721004351	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004352	metal-binding site [ion binding]
232721004353	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721004354	Soluble P-type ATPase [General function prediction only]; Region: COG4087
232721004355	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
232721004356	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
232721004357	DNA binding residues [nucleotide binding]
232721004358	dimer interface [polypeptide binding]; other site
232721004359	putative metal binding site [ion binding]; other site
232721004360	Phage integrase protein; Region: DUF3701; pfam12482
232721004361	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
232721004362	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
232721004363	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
232721004364	active site
232721004365	DNA binding site [nucleotide binding]
232721004366	Int/Topo IB signature motif; other site
232721004367	Sulfatase; Region: Sulfatase; cl17466
232721004368	integrase; Provisional; Region: PRK09692
232721004369	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
232721004370	active site
232721004371	Int/Topo IB signature motif; other site
232721004372	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721004373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721004374	Walker A motif; other site
232721004375	ATP binding site [chemical binding]; other site
232721004376	Walker B motif; other site
232721004377	Homeodomain-like domain; Region: HTH_23; pfam13384
232721004378	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721004379	Integrase core domain; Region: rve; pfam00665
232721004380	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721004381	LysR substrate binding domain; Region: LysR_substrate; pfam03466
232721004382	dimerization interface [polypeptide binding]; other site
232721004383	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
232721004384	Integrase core domain; Region: rve; pfam00665
232721004385	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
232721004386	Bacterial TniB protein; Region: TniB; pfam05621
232721004387	AAA domain; Region: AAA_22; pfam13401
232721004388	TniQ; Region: TniQ; pfam06527
232721004389	Helix-turn-helix domain; Region: HTH_28; pfam13518
232721004390	Winged helix-turn helix; Region: HTH_29; pfam13551
232721004391	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
232721004392	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721004393	non-specific DNA binding site [nucleotide binding]; other site
232721004394	salt bridge; other site
232721004395	sequence-specific DNA binding site [nucleotide binding]; other site
232721004396	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721004397	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721004398	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
232721004399	dimerization interface [polypeptide binding]; other site
232721004400	substrate binding pocket [chemical binding]; other site
232721004401	DsrE/DsrF-like family; Region: DrsE; cl00672
232721004402	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
232721004403	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
232721004404	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
232721004405	Domain of unknown function DUF302; Region: DUF302; pfam03625
232721004406	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
232721004407	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
232721004408	dimerization domain [polypeptide binding]; other site
232721004409	dimer interface [polypeptide binding]; other site
232721004410	catalytic residues [active]
232721004411	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
232721004412	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
232721004413	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
232721004414	catalytic residues [active]
232721004415	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
232721004416	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
232721004417	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
232721004418	DsbD alpha interface [polypeptide binding]; other site
232721004419	catalytic residues [active]
232721004420	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
232721004421	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721004422	active site
232721004423	phosphorylation site [posttranslational modification]
232721004424	intermolecular recognition site; other site
232721004425	dimerization interface [polypeptide binding]; other site
232721004426	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721004427	DNA binding site [nucleotide binding]
232721004428	sensor protein QseC; Provisional; Region: PRK10337
232721004429	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721004430	dimer interface [polypeptide binding]; other site
232721004431	phosphorylation site [posttranslational modification]
232721004432	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721004433	ATP binding site [chemical binding]; other site
232721004434	Mg2+ binding site [ion binding]; other site
232721004435	G-X-G motif; other site
232721004436	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
232721004437	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
232721004438	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721004439	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
232721004440	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
232721004441	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
232721004442	catalytic residues [active]
232721004443	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721004444	dimerization interface [polypeptide binding]; other site
232721004445	putative DNA binding site [nucleotide binding]; other site
232721004446	putative Zn2+ binding site [ion binding]; other site
232721004447	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
232721004448	active site residue [active]
232721004449	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
232721004450	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
232721004451	catalytic residues [active]
232721004452	hinge region; other site
232721004453	alpha helical domain; other site
232721004454	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
232721004455	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
232721004456	DsrE/DsrF-like family; Region: DrsE; pfam02635
232721004457	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
232721004458	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
232721004459	gating phenylalanine in ion channel; other site
232721004460	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004461	metal-binding site [ion binding]
232721004462	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721004463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721004464	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
232721004465	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
232721004466	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721004467	dimerization interface [polypeptide binding]; other site
232721004468	putative DNA binding site [nucleotide binding]; other site
232721004469	putative Zn2+ binding site [ion binding]; other site
232721004470	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004471	metal-binding site [ion binding]
232721004472	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
232721004473	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004474	metal-binding site [ion binding]
232721004475	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721004476	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721004477	motif II; other site
232721004478	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
232721004479	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
232721004480	DNA binding residues [nucleotide binding]
232721004481	dimer interface [polypeptide binding]; other site
232721004482	copper binding site [ion binding]; other site
232721004483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721004484	putative substrate translocation pore; other site
232721004485	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
232721004486	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
232721004487	putative NAD(P) binding site [chemical binding]; other site
232721004488	putative substrate binding site [chemical binding]; other site
232721004489	catalytic Zn binding site [ion binding]; other site
232721004490	structural Zn binding site [ion binding]; other site
232721004491	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
232721004492	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721004493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721004494	homodimer interface [polypeptide binding]; other site
232721004495	catalytic residue [active]
232721004496	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
232721004497	Homeodomain-like domain; Region: HTH_23; pfam13384
232721004498	Winged helix-turn helix; Region: HTH_29; pfam13551
232721004499	Homeodomain-like domain; Region: HTH_32; pfam13565
232721004500	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721004501	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721004502	Homeodomain-like domain; Region: HTH_23; pfam13384
232721004503	Winged helix-turn helix; Region: HTH_29; pfam13551
232721004504	Homeodomain-like domain; Region: HTH_32; pfam13565
232721004505	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721004506	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721004507	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
232721004508	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
232721004509	classical (c) SDRs; Region: SDR_c; cd05233
232721004510	NAD(P) binding site [chemical binding]; other site
232721004511	active site
232721004512	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
232721004513	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721004514	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
232721004515	dimerization interface [polypeptide binding]; other site
232721004516	substrate binding pocket [chemical binding]; other site
232721004517	DsrE/DsrF-like family; Region: DrsE; pfam02635
232721004518	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
232721004519	Putative helicase; Region: TraI_2; pfam07514
232721004520	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
232721004521	RES domain; Region: RES; smart00953
232721004522	Protein of unknown function (DUF3742); Region: DUF3742; pfam12553
232721004523	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
232721004524	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
232721004525	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
232721004526	integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757
232721004527	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
232721004528	MPN+ (JAMM) motif; other site
232721004529	Zinc-binding site [ion binding]; other site
232721004530	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
232721004531	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
232721004532	catalytic residues [active]
232721004533	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
232721004534	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
232721004535	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
232721004536	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
232721004537	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
232721004538	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
232721004539	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
232721004540	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
232721004541	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
232721004542	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
232721004543	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
232721004544	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
232721004545	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
232721004546	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
232721004547	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
232721004548	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721004549	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721004550	catalytic residue [active]
232721004551	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
232721004552	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
232721004553	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
232721004554	Cytochrome c; Region: Cytochrom_C; pfam00034
232721004555	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
232721004556	Cytochrome c; Region: Cytochrom_C; pfam00034
232721004557	Cytochrome c [Energy production and conversion]; Region: COG3258
232721004558	Cytochrome c; Region: Cytochrom_C; pfam00034
232721004559	DEAD-like helicases superfamily; Region: DEXDc; smart00487
232721004560	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721004561	nucleotide binding region [chemical binding]; other site
232721004562	ATP-binding site [chemical binding]; other site
232721004563	Methyltransferase domain; Region: Methyltransf_26; pfam13659
232721004564	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721004565	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721004566	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721004567	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
232721004568	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
232721004569	Transposase; Region: DDE_Tnp_ISL3; pfam01610
232721004570	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
232721004571	Transposase domain (DUF772); Region: DUF772; pfam05598
232721004572	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721004573	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721004574	Protein of unknown function (DUF3275); Region: DUF3275; pfam11679
232721004575	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
232721004576	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
232721004577	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
232721004578	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
232721004579	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
232721004580	cofactor binding site; other site
232721004581	DNA binding site [nucleotide binding]
232721004582	substrate interaction site [chemical binding]; other site
232721004583	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
232721004584	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
232721004585	DNA topoisomerase III; Provisional; Region: PRK07726
232721004586	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
232721004587	active site
232721004588	putative interdomain interaction site [polypeptide binding]; other site
232721004589	putative metal-binding site [ion binding]; other site
232721004590	putative nucleotide binding site [chemical binding]; other site
232721004591	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
232721004592	domain I; other site
232721004593	DNA binding groove [nucleotide binding]
232721004594	phosphate binding site [ion binding]; other site
232721004595	domain II; other site
232721004596	domain III; other site
232721004597	nucleotide binding site [chemical binding]; other site
232721004598	catalytic site [active]
232721004599	domain IV; other site
232721004600	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
232721004601	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
232721004602	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
232721004603	ssDNA binding site [nucleotide binding]; other site
232721004604	dimer interface [polypeptide binding]; other site
232721004605	tetramer (dimer of dimers) interface [polypeptide binding]; other site
232721004606	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
232721004607	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
232721004608	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
232721004609	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
232721004610	ParB-like nuclease domain; Region: ParBc; pfam02195
232721004611	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
232721004612	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
232721004613	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721004614	Magnesium ion binding site [ion binding]; other site
232721004615	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
232721004616	Uncharacterized conserved small protein [Function unknown]; Region: COG5639
232721004617	Transposase; Region: HTH_Tnp_1; pfam01527
232721004618	Transposase domain (DUF772); Region: DUF772; pfam05598
232721004619	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721004620	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721004621	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
232721004622	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721004623	dimerization interface [polypeptide binding]; other site
232721004624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721004625	dimer interface [polypeptide binding]; other site
232721004626	phosphorylation site [posttranslational modification]
232721004627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721004628	ATP binding site [chemical binding]; other site
232721004629	Mg2+ binding site [ion binding]; other site
232721004630	G-X-G motif; other site
232721004631	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
232721004632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721004633	active site
232721004634	phosphorylation site [posttranslational modification]
232721004635	intermolecular recognition site; other site
232721004636	dimerization interface [polypeptide binding]; other site
232721004637	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721004638	DNA binding site [nucleotide binding]
232721004639	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
232721004640	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
232721004641	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
232721004642	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004643	metal-binding site [ion binding]
232721004644	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
232721004645	YHS domain; Region: YHS; pfam04945
232721004646	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
232721004647	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721004648	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721004649	motif II; other site
232721004650	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
232721004651	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
232721004652	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
232721004653	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
232721004654	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
232721004655	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
232721004656	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
232721004657	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
232721004658	hypothetical protein; Provisional; Region: PRK02237
232721004659	putative transcriptional regulator MerR; Provisional; Region: PRK13752
232721004660	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
232721004661	DNA binding residues [nucleotide binding]
232721004662	dimer interface [polypeptide binding]; other site
232721004663	mercury binding site [ion binding]; other site
232721004664	putative mercuric transport protein; Provisional; Region: PRK13751
232721004665	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004666	metal-binding site [ion binding]
232721004667	Predicted membrane protein [Function unknown]; Region: COG3174
232721004668	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
232721004669	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
232721004670	Outer membrane efflux protein; Region: OEP; pfam02321
232721004671	Outer membrane efflux protein; Region: OEP; pfam02321
232721004672	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
232721004673	Trehalase; Region: Trehalase; cl17346
232721004674	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721004675	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
232721004676	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
232721004677	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
232721004678	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
232721004679	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004680	metal-binding site [ion binding]
232721004681	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
232721004682	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721004683	S-adenosylmethionine binding site [chemical binding]; other site
232721004684	FtsH Extracellular; Region: FtsH_ext; pfam06480
232721004685	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
232721004686	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721004687	Walker A motif; other site
232721004688	ATP binding site [chemical binding]; other site
232721004689	Walker B motif; other site
232721004690	arginine finger; other site
232721004691	Peptidase family M41; Region: Peptidase_M41; pfam01434
232721004692	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
232721004693	XFP N-terminal domain; Region: XFP_N; pfam09364
232721004694	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
232721004695	ABC1 family; Region: ABC1; cl17513
232721004696	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
232721004697	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
232721004698	protein binding site [polypeptide binding]; other site
232721004699	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
232721004700	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
232721004701	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
232721004702	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
232721004703	active site
232721004704	thymidine phosphorylase; Provisional; Region: PRK04350
232721004705	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
232721004706	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
232721004707	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
232721004708	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
232721004709	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
232721004710	Beta-Casp domain; Region: Beta-Casp; smart01027
232721004711	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
232721004712	Repair protein; Region: Repair_PSII; pfam04536
232721004713	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
232721004714	Repair protein; Region: Repair_PSII; pfam04536
232721004715	LemA family; Region: LemA; pfam04011
232721004716	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721004717	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
232721004718	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721004719	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721004720	motif II; other site
232721004721	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
232721004722	Transposase domain (DUF772); Region: DUF772; pfam05598
232721004723	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721004724	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721004725	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
232721004726	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
232721004727	N-terminal plug; other site
232721004728	ligand-binding site [chemical binding]; other site
232721004729	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
232721004730	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
232721004731	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
232721004732	F plasmid transfer operon protein; Region: TraF; pfam13728
232721004733	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
232721004734	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
232721004735	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
232721004736	TraU protein; Region: TraU; pfam06834
232721004737	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
232721004738	conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771
232721004739	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
232721004740	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
232721004741	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
232721004742	Walker A motif; other site
232721004743	ATP binding site [chemical binding]; other site
232721004744	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
232721004745	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
232721004746	dimerization domain [polypeptide binding]; other site
232721004747	dimer interface [polypeptide binding]; other site
232721004748	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
232721004749	catalytic residues [active]
232721004750	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
232721004751	TraK protein; Region: TraK; pfam06586
232721004752	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
232721004753	TraE protein; Region: TraE; cl05060
232721004754	TraL protein; Region: TraL; pfam07178
232721004755	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
232721004756	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721004757	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721004758	catalytic residue [active]
232721004759	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
232721004760	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721004761	sequence-specific DNA binding site [nucleotide binding]; other site
232721004762	salt bridge; other site
232721004763	Domain of unknown function (DUF4400); Region: DUF4400; cl14023
232721004764	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
232721004765	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
232721004766	Putative helicase; Region: TraI_2; pfam07514
232721004767	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
232721004768	Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
232721004769	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
232721004770	Predicted transcriptional regulator [Transcription]; Region: COG2932
232721004771	Catalytic site [active]
232721004772	Domain of unknown function (DUF932); Region: DUF932; cl12129
232721004773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
232721004774	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
232721004775	CHC2 zinc finger; Region: zf-CHC2; cl17510
232721004776	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
232721004777	active site
232721004778	metal binding site [ion binding]; metal-binding site
232721004779	interdomain interaction site; other site
232721004780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
232721004781	ATP binding site [chemical binding]; other site
232721004782	Mg2+ binding site [ion binding]; other site
232721004783	G-X-G motif; other site
232721004784	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
232721004785	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
232721004786	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
232721004787	active site
232721004788	catalytic residues [active]
232721004789	Int/Topo IB signature motif; other site
232721004790	DNA binding site [nucleotide binding]
232721004791	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
232721004792	active site
232721004793	metal binding site [ion binding]; metal-binding site
232721004794	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
232721004795	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
232721004796	Walker A motif; other site
232721004797	ATP binding site [chemical binding]; other site
232721004798	Walker B motif; other site
232721004799	arginine finger; other site
232721004800	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
232721004801	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721004802	AAA domain; Region: AAA_23; pfam13476
232721004803	Walker A/P-loop; other site
232721004804	ATP binding site [chemical binding]; other site
232721004805	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721004806	ABC transporter signature motif; other site
232721004807	Walker B; other site
232721004808	D-loop; other site
232721004809	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721004810	S-adenosylmethionine binding site [chemical binding]; other site
232721004811	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
232721004812	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
232721004813	DEAD-like helicases superfamily; Region: DEXDc; smart00487
232721004814	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
232721004815	helicase superfamily c-terminal domain; Region: HELICc; smart00490
232721004816	RES domain; Region: RES; pfam08808
232721004817	AAA domain; Region: AAA_21; pfam13304
232721004818	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
232721004819	Helix-turn-helix domain; Region: HTH_17; pfam12728
232721004820	PIN domain; Region: PIN_3; pfam13470
232721004821	Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216
232721004822	IHF dimer interface [polypeptide binding]; other site
232721004823	IHF - DNA interface [nucleotide binding]; other site
232721004824	ParB-like nuclease domain; Region: ParB; smart00470
232721004825	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
232721004826	PRTRC system protein E; Region: PRTRC_E; TIGR03741
232721004827	PRTRC system protein C; Region: PRTRC_C; TIGR03738
232721004828	PRTRC system protein F; Region: PRTRC_F; TIGR03742
232721004829	Alpha-helical domain 2; Region: alpha-hel2; pfam14456
232721004830	PRTRC system protein B; Region: PRTRC_B; TIGR03737
232721004831	Domain of unknown function (DUF2016); Region: DUF2016; pfam09436
232721004832	PRTRC system protein A; Region: PRTRC_A; TIGR03735
232721004833	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
232721004834	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
232721004835	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
232721004836	ATP binding site [chemical binding]; other site
232721004837	H-NS histone family; Region: Histone_HNS; pfam00816
232721004838	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
232721004839	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
232721004840	Integrase; Region: Integrase_1; pfam12835
232721004841	PRTRC system protein D; Region: PRTRC_D; TIGR03739
232721004842	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
232721004843	Mg binding site [ion binding]; other site
232721004844	nucleotide binding site [chemical binding]; other site
232721004845	putative protofilament interface [polypeptide binding]; other site
232721004846	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
232721004847	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
232721004848	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
232721004849	active site
232721004850	Int/Topo IB signature motif; other site
232721004851	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
232721004852	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
232721004853	NAD binding site [chemical binding]; other site
232721004854	homodimer interface [polypeptide binding]; other site
232721004855	homotetramer interface [polypeptide binding]; other site
232721004856	active site
232721004857	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
232721004858	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
232721004859	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
232721004860	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
232721004861	active site
232721004862	HIGH motif; other site
232721004863	nucleotide binding site [chemical binding]; other site
232721004864	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
232721004865	active site
232721004866	KMSKS motif; other site
232721004867	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
232721004868	Dehydroquinase class II; Region: DHquinase_II; pfam01220
232721004869	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
232721004870	trimer interface [polypeptide binding]; other site
232721004871	active site
232721004872	dimer interface [polypeptide binding]; other site
232721004873	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
232721004874	hypothetical protein; Provisional; Region: PRK09256
232721004875	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
232721004876	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
232721004877	putative active site [active]
232721004878	metal binding site [ion binding]; metal-binding site
232721004879	Predicted esterase [General function prediction only]; Region: COG0400
232721004880	putative hydrolase; Provisional; Region: PRK11460
232721004881	Protein of unknown function (DUF3014); Region: DUF3014; pfam11219
232721004882	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721004883	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721004884	putative DNA binding site [nucleotide binding]; other site
232721004885	putative Zn2+ binding site [ion binding]; other site
232721004886	AsnC family; Region: AsnC_trans_reg; pfam01037
232721004887	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
232721004888	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
232721004889	dimer interface [polypeptide binding]; other site
232721004890	TPP-binding site [chemical binding]; other site
232721004891	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
232721004892	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
232721004893	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
232721004894	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
232721004895	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
232721004896	putative active site [active]
232721004897	putative metal binding site [ion binding]; other site
232721004898	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
232721004899	substrate binding site [chemical binding]; other site
232721004900	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
232721004901	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
232721004902	substrate binding site [chemical binding]; other site
232721004903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
232721004904	TPR motif; other site
232721004905	TPR repeat; Region: TPR_11; pfam13414
232721004906	binding surface
232721004907	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
232721004908	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
232721004909	active site
232721004910	HIGH motif; other site
232721004911	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
232721004912	KMSKS motif; other site
232721004913	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
232721004914	tRNA binding surface [nucleotide binding]; other site
232721004915	anticodon binding site; other site
232721004916	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
232721004917	endonuclease III; Region: ENDO3c; smart00478
232721004918	minor groove reading motif; other site
232721004919	helix-hairpin-helix signature motif; other site
232721004920	substrate binding pocket [chemical binding]; other site
232721004921	active site
232721004922	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
232721004923	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
232721004924	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
232721004925	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
232721004926	Ligand Binding Site [chemical binding]; other site
232721004927	TilS substrate binding domain; Region: TilS; pfam09179
232721004928	aspartate kinase; Reviewed; Region: PRK06635
232721004929	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
232721004930	putative nucleotide binding site [chemical binding]; other site
232721004931	putative catalytic residues [active]
232721004932	putative Mg ion binding site [ion binding]; other site
232721004933	putative aspartate binding site [chemical binding]; other site
232721004934	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
232721004935	putative allosteric regulatory site; other site
232721004936	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
232721004937	putative allosteric regulatory residue; other site
232721004938	Predicted integral membrane protein [Function unknown]; Region: COG5615
232721004939	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
232721004940	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
232721004941	THF binding site; other site
232721004942	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
232721004943	substrate binding site [chemical binding]; other site
232721004944	THF binding site; other site
232721004945	zinc-binding site [ion binding]; other site
232721004946	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
232721004947	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721004948	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
232721004949	putative dimerization interface [polypeptide binding]; other site
232721004950	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
232721004951	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
232721004952	tetramer interface [polypeptide binding]; other site
232721004953	active site
232721004954	Mg2+/Mn2+ binding site [ion binding]; other site
232721004955	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
232721004956	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
232721004957	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
232721004958	substrate binding site [chemical binding]; other site
232721004959	ligand binding site [chemical binding]; other site
232721004960	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
232721004961	substrate binding site [chemical binding]; other site
232721004962	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
232721004963	methylcitrate synthase; Provisional; Region: PRK12351
232721004964	oxalacetate binding site [chemical binding]; other site
232721004965	citrylCoA binding site [chemical binding]; other site
232721004966	coenzyme A binding site [chemical binding]; other site
232721004967	catalytic triad [active]
232721004968	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
232721004969	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
232721004970	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721004971	sequence-specific DNA binding site [nucleotide binding]; other site
232721004972	salt bridge; other site
232721004973	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
232721004974	Domain of unknown function (DUF955); Region: DUF955; pfam06114
232721004975	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
232721004976	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
232721004977	RNA binding surface [nucleotide binding]; other site
232721004978	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
232721004979	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
232721004980	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721004981	dimer interface [polypeptide binding]; other site
232721004982	phosphorylation site [posttranslational modification]
232721004983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721004984	ATP binding site [chemical binding]; other site
232721004985	Mg2+ binding site [ion binding]; other site
232721004986	G-X-G motif; other site
232721004987	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
232721004988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721004989	active site
232721004990	phosphorylation site [posttranslational modification]
232721004991	intermolecular recognition site; other site
232721004992	dimerization interface [polypeptide binding]; other site
232721004993	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721004994	DNA binding site [nucleotide binding]
232721004995	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
232721004996	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
232721004997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
232721004998	PAS domain; Region: PAS; smart00091
232721004999	putative active site [active]
232721005000	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
232721005001	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
232721005002	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
232721005003	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
232721005004	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
232721005005	active site residue [active]
232721005006	putative inner membrane protein; Provisional; Region: PRK11099
232721005007	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
232721005008	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
232721005009	active site residue [active]
232721005010	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
232721005011	active site residue [active]
232721005012	ferrochelatase; Reviewed; Region: hemH; PRK00035
232721005013	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
232721005014	C-terminal domain interface [polypeptide binding]; other site
232721005015	active site
232721005016	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
232721005017	active site
232721005018	N-terminal domain interface [polypeptide binding]; other site
232721005019	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
232721005020	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721005021	motif II; other site
232721005022	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
232721005023	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
232721005024	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721005025	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
232721005026	Soluble P-type ATPase [General function prediction only]; Region: COG4087
232721005027	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
232721005028	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
232721005029	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
232721005030	nucleophilic elbow; other site
232721005031	catalytic triad; other site
232721005032	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
232721005033	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
232721005034	homodimer interface [polypeptide binding]; other site
232721005035	substrate-cofactor binding pocket; other site
232721005036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721005037	catalytic residue [active]
232721005038	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
232721005039	FOG: CBS domain [General function prediction only]; Region: COG0517
232721005040	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
232721005041	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
232721005042	Tetramer interface [polypeptide binding]; other site
232721005043	active site
232721005044	FMN-binding site [chemical binding]; other site
232721005045	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
232721005046	ATP cone domain; Region: ATP-cone; pfam03477
232721005047	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
232721005048	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
232721005049	dimer interface [polypeptide binding]; other site
232721005050	active site
232721005051	glycine-pyridoxal phosphate binding site [chemical binding]; other site
232721005052	folate binding site [chemical binding]; other site
232721005053	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
232721005054	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721005055	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721005056	catalytic residue [active]
232721005057	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
232721005058	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
232721005059	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
232721005060	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
232721005061	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
232721005062	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
232721005063	Transcriptional regulator; Region: Rrf2; cl17282
232721005064	Rrf2 family protein; Region: rrf2_super; TIGR00738
232721005065	N-formylglutamate amidohydrolase; Region: FGase; cl01522
232721005066	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
232721005067	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
232721005068	HPP family; Region: HPP; pfam04982
232721005069	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
232721005070	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
232721005071	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
232721005072	rRNA binding site [nucleotide binding]; other site
232721005073	predicted 30S ribosome binding site; other site
232721005074	Protein of unknown function (DUF1624); Region: DUF1624; pfam07786
232721005075	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
232721005076	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
232721005077	intracellular septation protein A; Reviewed; Region: PRK00259
232721005078	methionine sulfoxide reductase B; Provisional; Region: PRK00222
232721005079	SelR domain; Region: SelR; pfam01641
232721005080	Uncharacterized conserved protein [Function unknown]; Region: COG0397
232721005081	hypothetical protein; Validated; Region: PRK00029
232721005082	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
232721005083	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
232721005084	dimer interface [polypeptide binding]; other site
232721005085	acyl-activating enzyme (AAE) consensus motif; other site
232721005086	putative active site [active]
232721005087	AMP binding site [chemical binding]; other site
232721005088	putative CoA binding site [chemical binding]; other site
232721005089	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
232721005090	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
232721005091	putative ligand binding site [chemical binding]; other site
232721005092	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
232721005093	TM-ABC transporter signature motif; other site
232721005094	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
232721005095	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
232721005096	TM-ABC transporter signature motif; other site
232721005097	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
232721005098	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
232721005099	Walker A/P-loop; other site
232721005100	ATP binding site [chemical binding]; other site
232721005101	Q-loop/lid; other site
232721005102	ABC transporter signature motif; other site
232721005103	Walker B; other site
232721005104	D-loop; other site
232721005105	H-loop/switch region; other site
232721005106	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
232721005107	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
232721005108	Walker A/P-loop; other site
232721005109	ATP binding site [chemical binding]; other site
232721005110	Q-loop/lid; other site
232721005111	ABC transporter signature motif; other site
232721005112	Walker B; other site
232721005113	D-loop; other site
232721005114	H-loop/switch region; other site
232721005115	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721005116	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
232721005117	substrate binding site [chemical binding]; other site
232721005118	oxyanion hole (OAH) forming residues; other site
232721005119	trimer interface [polypeptide binding]; other site
232721005120	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
232721005121	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
232721005122	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
232721005123	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
232721005124	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721005125	dimer interface [polypeptide binding]; other site
232721005126	active site
232721005127	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721005128	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721005129	metal binding site [ion binding]; metal-binding site
232721005130	active site
232721005131	I-site; other site
232721005132	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
232721005133	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
232721005134	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721005135	active site
232721005136	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
232721005137	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
232721005138	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
232721005139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
232721005140	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
232721005141	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
232721005142	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
232721005143	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
232721005144	Walker A/P-loop; other site
232721005145	ATP binding site [chemical binding]; other site
232721005146	Q-loop/lid; other site
232721005147	ABC transporter signature motif; other site
232721005148	Walker B; other site
232721005149	D-loop; other site
232721005150	H-loop/switch region; other site
232721005151	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
232721005152	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
232721005153	substrate binding pocket [chemical binding]; other site
232721005154	membrane-bound complex binding site; other site
232721005155	hinge residues; other site
232721005156	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721005157	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721005158	putative substrate translocation pore; other site
232721005159	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
232721005160	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
232721005161	putative ligand binding site [chemical binding]; other site
232721005162	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
232721005163	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721005164	NAD(P) binding site [chemical binding]; other site
232721005165	active site
232721005166	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
232721005167	CoenzymeA binding site [chemical binding]; other site
232721005168	subunit interaction site [polypeptide binding]; other site
232721005169	PHB binding site; other site
232721005170	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
232721005171	Prostaglandin dehydrogenases; Region: PGDH; cd05288
232721005172	NAD(P) binding site [chemical binding]; other site
232721005173	substrate binding site [chemical binding]; other site
232721005174	dimer interface [polypeptide binding]; other site
232721005175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
232721005176	Coenzyme A binding pocket [chemical binding]; other site
232721005177	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
232721005178	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
232721005179	C-terminal domain interface [polypeptide binding]; other site
232721005180	GSH binding site (G-site) [chemical binding]; other site
232721005181	dimer interface [polypeptide binding]; other site
232721005182	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
232721005183	dimer interface [polypeptide binding]; other site
232721005184	N-terminal domain interface [polypeptide binding]; other site
232721005185	substrate binding pocket (H-site) [chemical binding]; other site
232721005186	hypothetical protein; Provisional; Region: PRK06194
232721005187	classical (c) SDRs; Region: SDR_c; cd05233
232721005188	NAD(P) binding site [chemical binding]; other site
232721005189	active site
232721005190	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
232721005191	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
232721005192	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721005193	putative substrate translocation pore; other site
232721005194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721005195	putative substrate translocation pore; other site
232721005196	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721005197	Protein of unknown function DUF72; Region: DUF72; pfam01904
232721005198	LabA_like proteins; Region: LabA_like; cd06167
232721005199	putative metal binding site [ion binding]; other site
232721005200	Uncharacterized conserved protein [Function unknown]; Region: COG1432
232721005201	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
232721005202	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
232721005203	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
232721005204	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
232721005205	RNA binding site [nucleotide binding]; other site
232721005206	HDOD domain; Region: HDOD; pfam08668
232721005207	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
232721005208	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721005209	dimerization interface [polypeptide binding]; other site
232721005210	PAS fold; Region: PAS; pfam00989
232721005211	PAS domain; Region: PAS_9; pfam13426
232721005212	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
232721005213	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
232721005214	putative active site [active]
232721005215	metal binding site [ion binding]; metal-binding site
232721005216	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
232721005217	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
232721005218	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
232721005219	substrate binding pocket [chemical binding]; other site
232721005220	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
232721005221	active site
232721005222	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
232721005223	Coenzyme A binding pocket [chemical binding]; other site
232721005224	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
232721005225	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
232721005226	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
232721005227	YceG-like family; Region: YceG; pfam02618
232721005228	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
232721005229	dimerization interface [polypeptide binding]; other site
232721005230	thymidylate kinase; Validated; Region: tmk; PRK00698
232721005231	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
232721005232	TMP-binding site; other site
232721005233	ATP-binding site [chemical binding]; other site
232721005234	DNA polymerase III subunit delta'; Validated; Region: PRK06964
232721005235	DNA polymerase III subunit delta'; Validated; Region: PRK08485
232721005236	PilZ domain; Region: PilZ; cl01260
232721005237	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
232721005238	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
232721005239	active site
232721005240	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
232721005241	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
232721005242	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
232721005243	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
232721005244	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
232721005245	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
232721005246	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
232721005247	Walker A/P-loop; other site
232721005248	ATP binding site [chemical binding]; other site
232721005249	Q-loop/lid; other site
232721005250	ABC transporter signature motif; other site
232721005251	Walker B; other site
232721005252	D-loop; other site
232721005253	H-loop/switch region; other site
232721005254	translocation protein TolB; Provisional; Region: tolB; PRK02889
232721005255	TolB amino-terminal domain; Region: TolB_N; pfam04052
232721005256	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
232721005257	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
232721005258	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
232721005259	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
232721005260	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
232721005261	ligand binding site [chemical binding]; other site
232721005262	tol-pal system protein YbgF; Provisional; Region: PRK10803
232721005263	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
232721005264	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
232721005265	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
232721005266	putative ATP binding site [chemical binding]; other site
232721005267	putative substrate interface [chemical binding]; other site
232721005268	Helix-turn-helix domain; Region: HTH_39; pfam14090
232721005269	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721005270	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
232721005271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721005272	Walker A motif; other site
232721005273	ATP binding site [chemical binding]; other site
232721005274	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721005275	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721005276	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721005277	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721005278	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721005279	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721005280	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721005281	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
232721005282	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721005283	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721005284	catalytic residue [active]
232721005285	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
232721005286	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
232721005287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
232721005288	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
232721005289	RNA/DNA hybrid binding site [nucleotide binding]; other site
232721005290	active site
232721005291	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
232721005292	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
232721005293	catalytic residues [active]
232721005294	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
232721005295	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
232721005296	dimer interface [polypeptide binding]; other site
232721005297	putative functional site; other site
232721005298	putative MPT binding site; other site
232721005299	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
232721005300	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
232721005301	GTP binding site; other site
232721005302	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
232721005303	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
232721005304	FeS/SAM binding site; other site
232721005305	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
232721005306	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
232721005307	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
232721005308	Homeodomain-like domain; Region: HTH_23; pfam13384
232721005309	Winged helix-turn helix; Region: HTH_29; pfam13551
232721005310	Homeodomain-like domain; Region: HTH_32; pfam13565
232721005311	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721005312	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721005313	Homeodomain-like domain; Region: HTH_23; pfam13384
232721005314	Winged helix-turn helix; Region: HTH_29; pfam13551
232721005315	Homeodomain-like domain; Region: HTH_32; pfam13565
232721005316	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721005317	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721005318	Transposase domain (DUF772); Region: DUF772; pfam05598
232721005319	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721005320	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721005321	Homeodomain-like domain; Region: HTH_23; pfam13384
232721005322	Winged helix-turn helix; Region: HTH_29; pfam13551
232721005323	Homeodomain-like domain; Region: HTH_32; pfam13565
232721005324	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721005325	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721005326	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
232721005327	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
232721005328	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
232721005329	NAD(P) binding site [chemical binding]; other site
232721005330	catalytic residues [active]
232721005331	catalytic residues [active]
232721005332	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
232721005333	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
232721005334	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
232721005335	dimer interface [polypeptide binding]; other site
232721005336	substrate binding site [chemical binding]; other site
232721005337	metal binding sites [ion binding]; metal-binding site
232721005338	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
232721005339	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
232721005340	Protein of unknown function, DUF482; Region: DUF482; pfam04339
232721005341	NAD synthetase; Provisional; Region: PRK13981
232721005342	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
232721005343	multimer interface [polypeptide binding]; other site
232721005344	active site
232721005345	catalytic triad [active]
232721005346	protein interface 1 [polypeptide binding]; other site
232721005347	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
232721005348	homodimer interface [polypeptide binding]; other site
232721005349	NAD binding pocket [chemical binding]; other site
232721005350	ATP binding pocket [chemical binding]; other site
232721005351	Mg binding site [ion binding]; other site
232721005352	active-site loop [active]
232721005353	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
232721005354	Nitrogen regulatory protein P-II; Region: P-II; smart00938
232721005355	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
232721005356	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
232721005357	RDD family; Region: RDD; pfam06271
232721005358	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
232721005359	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
232721005360	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
232721005361	RNA polymerase factor sigma-70; Validated; Region: PRK09047
232721005362	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
232721005363	DNA binding residues [nucleotide binding]
232721005364	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
232721005365	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
232721005366	PYR/PP interface [polypeptide binding]; other site
232721005367	dimer interface [polypeptide binding]; other site
232721005368	TPP binding site [chemical binding]; other site
232721005369	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
232721005370	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
232721005371	TPP-binding site [chemical binding]; other site
232721005372	dimer interface [polypeptide binding]; other site
232721005373	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
232721005374	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
232721005375	putative valine binding site [chemical binding]; other site
232721005376	dimer interface [polypeptide binding]; other site
232721005377	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
232721005378	ketol-acid reductoisomerase; Provisional; Region: PRK05479
232721005379	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
232721005380	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
232721005381	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
232721005382	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
232721005383	2-isopropylmalate synthase; Validated; Region: PRK03739
232721005384	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
232721005385	active site
232721005386	catalytic residues [active]
232721005387	metal binding site [ion binding]; metal-binding site
232721005388	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
232721005389	2-isopropylmalate synthase; Validated; Region: PRK00915
232721005390	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
232721005391	active site
232721005392	catalytic residues [active]
232721005393	metal binding site [ion binding]; metal-binding site
232721005394	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
232721005395	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
232721005396	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
232721005397	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
232721005398	Transcriptional regulator [Transcription]; Region: IclR; COG1414
232721005399	Bacterial transcriptional regulator; Region: IclR; pfam01614
232721005400	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721005401	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
232721005402	FAD binding site [chemical binding]; other site
232721005403	substrate binding site [chemical binding]; other site
232721005404	catalytic base [active]
232721005405	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
232721005406	putative active site [active]
232721005407	putative substrate binding site [chemical binding]; other site
232721005408	ATP binding site [chemical binding]; other site
232721005409	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
232721005410	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
232721005411	ligand binding site [chemical binding]; other site
232721005412	flexible hinge region; other site
232721005413	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
232721005414	enoyl-CoA hydratase; Provisional; Region: PRK07511
232721005415	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721005416	substrate binding site [chemical binding]; other site
232721005417	oxyanion hole (OAH) forming residues; other site
232721005418	trimer interface [polypeptide binding]; other site
232721005419	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
232721005420	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
232721005421	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
232721005422	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
232721005423	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
232721005424	thiamine phosphate binding site [chemical binding]; other site
232721005425	active site
232721005426	pyrophosphate binding site [ion binding]; other site
232721005427	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
232721005428	ThiS interaction site; other site
232721005429	putative active site [active]
232721005430	tetramer interface [polypeptide binding]; other site
232721005431	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
232721005432	thiS-thiF/thiG interaction site; other site
232721005433	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
232721005434	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
232721005435	dimer interface [polypeptide binding]; other site
232721005436	substrate binding site [chemical binding]; other site
232721005437	ATP binding site [chemical binding]; other site
232721005438	Bacterial SH3 domain; Region: SH3_4; pfam06347
232721005439	Bacterial SH3 domain; Region: SH3_3; pfam08239
232721005440	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
232721005441	Ferredoxin [Energy production and conversion]; Region: COG1146
232721005442	4Fe-4S binding domain; Region: Fer4; cl02805
232721005443	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
232721005444	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
232721005445	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
232721005446	G1 box; other site
232721005447	GTP/Mg2+ binding site [chemical binding]; other site
232721005448	G2 box; other site
232721005449	Switch I region; other site
232721005450	G3 box; other site
232721005451	Switch II region; other site
232721005452	G4 box; other site
232721005453	G5 box; other site
232721005454	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
232721005455	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
232721005456	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
232721005457	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
232721005458	Active Sites [active]
232721005459	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
232721005460	Active Sites [active]
232721005461	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
232721005462	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
232721005463	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
232721005464	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
232721005465	Uncharacterized conserved protein [Function unknown]; Region: COG4121
232721005466	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
232721005467	Predicted membrane protein [Function unknown]; Region: COG2860
232721005468	UPF0126 domain; Region: UPF0126; pfam03458
232721005469	UPF0126 domain; Region: UPF0126; pfam03458
232721005470	oxidative damage protection protein; Provisional; Region: PRK05408
232721005471	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
232721005472	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
232721005473	substrate binding pocket [chemical binding]; other site
232721005474	membrane-bound complex binding site; other site
232721005475	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
232721005476	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
232721005477	putative C-terminal domain interface [polypeptide binding]; other site
232721005478	putative GSH binding site (G-site) [chemical binding]; other site
232721005479	putative dimer interface [polypeptide binding]; other site
232721005480	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
232721005481	putative N-terminal domain interface [polypeptide binding]; other site
232721005482	putative dimer interface [polypeptide binding]; other site
232721005483	putative substrate binding pocket (H-site) [chemical binding]; other site
232721005484	DNA photolyase; Region: DNA_photolyase; pfam00875
232721005485	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
232721005486	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
232721005487	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
232721005488	Int/Topo IB signature motif; other site
232721005489	multiple promoter invertase; Provisional; Region: mpi; PRK13413
232721005490	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
232721005491	catalytic residues [active]
232721005492	catalytic nucleophile [active]
232721005493	Presynaptic Site I dimer interface [polypeptide binding]; other site
232721005494	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
232721005495	Synaptic Flat tetramer interface [polypeptide binding]; other site
232721005496	Synaptic Site I dimer interface [polypeptide binding]; other site
232721005497	DNA binding site [nucleotide binding]
232721005498	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
232721005499	DNA-binding interface [nucleotide binding]; DNA binding site
232721005500	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
232721005501	sequence-specific DNA binding site [nucleotide binding]; other site
232721005502	salt bridge; other site
232721005503	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
232721005504	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
232721005505	NAD binding site [chemical binding]; other site
232721005506	homotetramer interface [polypeptide binding]; other site
232721005507	homodimer interface [polypeptide binding]; other site
232721005508	substrate binding site [chemical binding]; other site
232721005509	active site
232721005510	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
232721005511	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
232721005512	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
232721005513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721005514	dimer interface [polypeptide binding]; other site
232721005515	conserved gate region; other site
232721005516	putative PBP binding loops; other site
232721005517	ABC-ATPase subunit interface; other site
232721005518	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
232721005519	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
232721005520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721005521	dimer interface [polypeptide binding]; other site
232721005522	conserved gate region; other site
232721005523	putative PBP binding loops; other site
232721005524	ABC-ATPase subunit interface; other site
232721005525	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
232721005526	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
232721005527	Walker A/P-loop; other site
232721005528	ATP binding site [chemical binding]; other site
232721005529	Q-loop/lid; other site
232721005530	ABC transporter signature motif; other site
232721005531	Walker B; other site
232721005532	D-loop; other site
232721005533	H-loop/switch region; other site
232721005534	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
232721005535	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
232721005536	Walker A/P-loop; other site
232721005537	ATP binding site [chemical binding]; other site
232721005538	Q-loop/lid; other site
232721005539	ABC transporter signature motif; other site
232721005540	Walker B; other site
232721005541	D-loop; other site
232721005542	H-loop/switch region; other site
232721005543	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
232721005544	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
232721005545	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
232721005546	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
232721005547	Ligand Binding Site [chemical binding]; other site
232721005548	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721005549	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721005550	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
232721005551	putative dimerization interface [polypeptide binding]; other site
232721005552	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
232721005553	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721005554	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
232721005555	Domain of unknown function DUF20; Region: UPF0118; pfam01594
232721005556	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
232721005557	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
232721005558	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
232721005559	TPP-binding site [chemical binding]; other site
232721005560	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
232721005561	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
232721005562	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
232721005563	E3 interaction surface; other site
232721005564	lipoyl attachment site [posttranslational modification]; other site
232721005565	e3 binding domain; Region: E3_binding; pfam02817
232721005566	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
232721005567	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
232721005568	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721005569	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
232721005570	Predicted ATPase [General function prediction only]; Region: COG1485
232721005571	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
232721005572	active site
232721005573	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
232721005574	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
232721005575	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
232721005576	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
232721005577	Tetratricopeptide repeat; Region: TPR_6; pfam13174
232721005578	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
232721005579	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
232721005580	putative active site [active]
232721005581	putative PHP Thumb interface [polypeptide binding]; other site
232721005582	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
232721005583	generic binding surface II; other site
232721005584	generic binding surface I; other site
232721005585	Uncharacterized conserved protein [Function unknown]; Region: COG2127
232721005586	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
232721005587	Clp amino terminal domain; Region: Clp_N; pfam02861
232721005588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721005589	Walker A motif; other site
232721005590	ATP binding site [chemical binding]; other site
232721005591	Walker B motif; other site
232721005592	arginine finger; other site
232721005593	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721005594	Walker A motif; other site
232721005595	ATP binding site [chemical binding]; other site
232721005596	Walker B motif; other site
232721005597	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
232721005598	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
232721005599	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721005600	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
232721005601	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
232721005602	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721005603	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
232721005604	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
232721005605	FtsX-like permease family; Region: FtsX; pfam02687
232721005606	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
232721005607	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
232721005608	Walker A/P-loop; other site
232721005609	ATP binding site [chemical binding]; other site
232721005610	Q-loop/lid; other site
232721005611	ABC transporter signature motif; other site
232721005612	Walker B; other site
232721005613	D-loop; other site
232721005614	H-loop/switch region; other site
232721005615	Transglycosylase SLT domain; Region: SLT_2; pfam13406
232721005616	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721005617	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721005618	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
232721005619	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
232721005620	exonuclease I; Provisional; Region: sbcB; PRK11779
232721005621	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
232721005622	active site
232721005623	catalytic site [active]
232721005624	substrate binding site [chemical binding]; other site
232721005625	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
232721005626	NAD-dependent deacetylase; Provisional; Region: PRK05333
232721005627	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
232721005628	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
232721005629	GAF domain; Region: GAF; pfam01590
232721005630	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721005631	Walker A motif; other site
232721005632	ATP binding site [chemical binding]; other site
232721005633	Walker B motif; other site
232721005634	arginine finger; other site
232721005635	HTH domain; Region: HTH_22; pfam13309
232721005636	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
232721005637	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
232721005638	putative transposase OrfB; Reviewed; Region: PHA02517
232721005639	HTH-like domain; Region: HTH_21; pfam13276
232721005640	Integrase core domain; Region: rve; pfam00665
232721005641	Integrase core domain; Region: rve_3; pfam13683
232721005642	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
232721005643	Transposase; Region: HTH_Tnp_1; pfam01527
232721005644	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
232721005645	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
232721005646	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
232721005647	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721005648	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
232721005649	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
232721005650	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
232721005651	DNA binding residues [nucleotide binding]
232721005652	dimer interface [polypeptide binding]; other site
232721005653	putative metal binding site [ion binding]; other site
232721005654	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
232721005655	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
232721005656	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721005657	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
232721005658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721005659	Walker A motif; other site
232721005660	ATP binding site [chemical binding]; other site
232721005661	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721005662	Integrase core domain; Region: rve; pfam00665
232721005663	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721005664	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
232721005665	putative metal dependent hydrolase; Provisional; Region: PRK11598
232721005666	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
232721005667	Sulfatase; Region: Sulfatase; pfam00884
232721005668	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
232721005669	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
232721005670	Homeodomain-like domain; Region: HTH_23; pfam13384
232721005671	Winged helix-turn helix; Region: HTH_29; pfam13551
232721005672	Homeodomain-like domain; Region: HTH_32; pfam13565
232721005673	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721005674	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721005675	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
232721005676	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
232721005677	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
232721005678	nucleophile elbow; other site
232721005679	Patatin phospholipase; Region: DUF3734; pfam12536
232721005680	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
232721005681	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
232721005682	Transposase; Region: DDE_Tnp_ISL3; pfam01610
232721005683	Predicted membrane protein [Function unknown]; Region: COG2323
232721005684	Transposase domain (DUF772); Region: DUF772; pfam05598
232721005685	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721005686	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721005687	Double zinc ribbon; Region: DZR; pfam12773
232721005688	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
232721005689	active site
232721005690	Homeodomain-like domain; Region: HTH_23; pfam13384
232721005691	Winged helix-turn helix; Region: HTH_29; pfam13551
232721005692	Homeodomain-like domain; Region: HTH_32; pfam13565
232721005693	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721005694	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721005695	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
232721005696	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
232721005697	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
232721005698	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721005699	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
232721005700	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
232721005701	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
232721005702	Phage integrase protein; Region: DUF3701; pfam12482
232721005703	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
232721005704	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
232721005705	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
232721005706	Int/Topo IB signature motif; other site
232721005707	Helix-turn-helix domain; Region: HTH_37; pfam13744
232721005708	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
232721005709	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
232721005710	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
232721005711	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
232721005712	active site
232721005713	DNA binding site [nucleotide binding]
232721005714	Int/Topo IB signature motif; other site
232721005715	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
232721005716	Protein of unknown function (DUF779); Region: DUF779; pfam05610
232721005717	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
232721005718	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
232721005719	NAD binding site [chemical binding]; other site
232721005720	substrate binding site [chemical binding]; other site
232721005721	catalytic Zn binding site [ion binding]; other site
232721005722	tetramer interface [polypeptide binding]; other site
232721005723	structural Zn binding site [ion binding]; other site
232721005724	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
232721005725	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
232721005726	NAD(P) binding site [chemical binding]; other site
232721005727	catalytic residues [active]
232721005728	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
232721005729	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
232721005730	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
232721005731	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
232721005732	GAF domain; Region: GAF; pfam01590
232721005733	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
232721005734	active site
232721005735	serine racemase; Region: PLN02970
232721005736	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
232721005737	tetramer interface [polypeptide binding]; other site
232721005738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721005739	catalytic residue [active]
232721005740	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
232721005741	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
232721005742	heme-binding site [chemical binding]; other site
232721005743	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
232721005744	FAD binding pocket [chemical binding]; other site
232721005745	FAD binding motif [chemical binding]; other site
232721005746	phosphate binding motif [ion binding]; other site
232721005747	beta-alpha-beta structure motif; other site
232721005748	NAD binding pocket [chemical binding]; other site
232721005749	Heme binding  pocket [chemical binding]; other site
232721005750	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
232721005751	GAF domain; Region: GAF; pfam01590
232721005752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721005753	Walker A motif; other site
232721005754	ATP binding site [chemical binding]; other site
232721005755	Walker B motif; other site
232721005756	arginine finger; other site
232721005757	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
232721005758	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
232721005759	Walker A motif; other site
232721005760	ATP binding site [chemical binding]; other site
232721005761	hypothetical protein; Validated; Region: PRK00110
232721005762	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
232721005763	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
232721005764	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
232721005765	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
232721005766	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
232721005767	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
232721005768	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
232721005769	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
232721005770	Maf-like protein; Region: Maf; pfam02545
232721005771	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
232721005772	active site
232721005773	dimer interface [polypeptide binding]; other site
232721005774	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
232721005775	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
232721005776	ligand binding site [chemical binding]; other site
232721005777	flexible hinge region; other site
232721005778	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
232721005779	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
232721005780	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
232721005781	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
232721005782	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
232721005783	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
232721005784	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
232721005785	FeS/SAM binding site; other site
232721005786	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
232721005787	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721005788	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
232721005789	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721005790	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721005791	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721005792	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
232721005793	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
232721005794	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
232721005795	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
232721005796	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
232721005797	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
232721005798	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
232721005799	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
232721005800	active site
232721005801	SAM binding site [chemical binding]; other site
232721005802	homodimer interface [polypeptide binding]; other site
232721005803	ribonuclease G; Provisional; Region: PRK11712
232721005804	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
232721005805	homodimer interface [polypeptide binding]; other site
232721005806	oligonucleotide binding site [chemical binding]; other site
232721005807	methionine aminotransferase; Validated; Region: PRK09082
232721005808	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721005809	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721005810	homodimer interface [polypeptide binding]; other site
232721005811	catalytic residue [active]
232721005812	Transposase domain (DUF772); Region: DUF772; pfam05598
232721005813	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721005814	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721005815	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682
232721005816	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721005817	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
232721005818	substrate binding site [chemical binding]; other site
232721005819	dimerization interface [polypeptide binding]; other site
232721005820	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
232721005821	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
232721005822	putative active site [active]
232721005823	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
232721005824	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
232721005825	Predicted permeases [General function prediction only]; Region: COG0795
232721005826	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
232721005827	multifunctional aminopeptidase A; Provisional; Region: PRK00913
232721005828	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
232721005829	interface (dimer of trimers) [polypeptide binding]; other site
232721005830	Substrate-binding/catalytic site; other site
232721005831	Zn-binding sites [ion binding]; other site
232721005832	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
232721005833	Homeodomain-like domain; Region: HTH_23; pfam13384
232721005834	Winged helix-turn helix; Region: HTH_29; pfam13551
232721005835	Homeodomain-like domain; Region: HTH_32; pfam13565
232721005836	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721005837	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721005838	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
232721005839	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
232721005840	dimerization interface [polypeptide binding]; other site
232721005841	ligand binding site [chemical binding]; other site
232721005842	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
232721005843	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
232721005844	dimerization interface [polypeptide binding]; other site
232721005845	NAD binding site [chemical binding]; other site
232721005846	ligand binding site [chemical binding]; other site
232721005847	catalytic site [active]
232721005848	Biofilm formation and stress response factor; Region: BsmA; pfam10014
232721005849	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
232721005850	Ligand Binding Site [chemical binding]; other site
232721005851	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
232721005852	beta-ketothiolase; Provisional; Region: PRK09051
232721005853	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721005854	dimer interface [polypeptide binding]; other site
232721005855	active site
232721005856	short chain dehydrogenase; Provisional; Region: PRK07023
232721005857	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721005858	NAD(P) binding site [chemical binding]; other site
232721005859	active site
232721005860	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
232721005861	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
232721005862	active site
232721005863	PAS domain; Region: PAS; smart00091
232721005864	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
232721005865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721005866	dimer interface [polypeptide binding]; other site
232721005867	phosphorylation site [posttranslational modification]
232721005868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721005869	ATP binding site [chemical binding]; other site
232721005870	Mg2+ binding site [ion binding]; other site
232721005871	G-X-G motif; other site
232721005872	Response regulator receiver domain; Region: Response_reg; pfam00072
232721005873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721005874	active site
232721005875	phosphorylation site [posttranslational modification]
232721005876	intermolecular recognition site; other site
232721005877	dimerization interface [polypeptide binding]; other site
232721005878	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
232721005879	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
232721005880	glycine dehydrogenase; Provisional; Region: PRK05367
232721005881	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
232721005882	tetramer interface [polypeptide binding]; other site
232721005883	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721005884	catalytic residue [active]
232721005885	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
232721005886	tetramer interface [polypeptide binding]; other site
232721005887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721005888	catalytic residue [active]
232721005889	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
232721005890	lipoyl attachment site [posttranslational modification]; other site
232721005891	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
232721005892	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
232721005893	DctM-like transporters; Region: DctM; pfam06808
232721005894	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
232721005895	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
232721005896	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
232721005897	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
232721005898	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721005899	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721005900	putative DNA binding site [nucleotide binding]; other site
232721005901	putative Zn2+ binding site [ion binding]; other site
232721005902	AsnC family; Region: AsnC_trans_reg; pfam01037
232721005903	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
232721005904	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721005905	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721005906	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721005907	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
232721005908	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
232721005909	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
232721005910	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
232721005911	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721005912	Walker A/P-loop; other site
232721005913	ATP binding site [chemical binding]; other site
232721005914	Q-loop/lid; other site
232721005915	ABC transporter signature motif; other site
232721005916	Walker B; other site
232721005917	D-loop; other site
232721005918	H-loop/switch region; other site
232721005919	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
232721005920	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
232721005921	TM-ABC transporter signature motif; other site
232721005922	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
232721005923	zinc binding site [ion binding]; other site
232721005924	putative ligand binding site [chemical binding]; other site
232721005925	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
232721005926	hydroxyglutarate oxidase; Provisional; Region: PRK11728
232721005927	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
232721005928	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
232721005929	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
232721005930	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
232721005931	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721005932	dimer interface [polypeptide binding]; other site
232721005933	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
232721005934	putative CheW interface [polypeptide binding]; other site
232721005935	sensor protein BasS/PmrB; Provisional; Region: PRK10755
232721005936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721005937	ATP binding site [chemical binding]; other site
232721005938	Mg2+ binding site [ion binding]; other site
232721005939	G-X-G motif; other site
232721005940	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
232721005941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721005942	active site
232721005943	phosphorylation site [posttranslational modification]
232721005944	intermolecular recognition site; other site
232721005945	dimerization interface [polypeptide binding]; other site
232721005946	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721005947	DNA binding site [nucleotide binding]
232721005948	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
232721005949	active site
232721005950	putative metal dependent hydrolase; Provisional; Region: PRK11598
232721005951	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
232721005952	Sulfatase; Region: Sulfatase; pfam00884
232721005953	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
232721005954	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
232721005955	DTW domain; Region: DTW; cl01221
232721005956	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
232721005957	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
232721005958	tetramer interface [polypeptide binding]; other site
232721005959	heme binding pocket [chemical binding]; other site
232721005960	NADPH binding site [chemical binding]; other site
232721005961	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
232721005962	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721005963	PAS domain; Region: PAS_9; pfam13426
232721005964	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721005965	putative active site [active]
232721005966	heme pocket [chemical binding]; other site
232721005967	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
232721005968	DNA binding residues [nucleotide binding]
232721005969	dimerization interface [polypeptide binding]; other site
232721005970	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
232721005971	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
232721005972	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
232721005973	Zn2+ binding site [ion binding]; other site
232721005974	Mg2+ binding site [ion binding]; other site
232721005975	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
232721005976	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
232721005977	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
232721005978	Uncharacterized conserved protein [Function unknown]; Region: COG4544
232721005979	Y-family of DNA polymerases; Region: PolY; cl12025
232721005980	DNA binding site [nucleotide binding]
232721005981	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
232721005982	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
232721005983	putative active site [active]
232721005984	putative PHP Thumb interface [polypeptide binding]; other site
232721005985	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
232721005986	generic binding surface II; other site
232721005987	generic binding surface I; other site
232721005988	Sel1-like repeats; Region: SEL1; smart00671
232721005989	Sel1 repeat; Region: Sel1; pfam08238
232721005990	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
232721005991	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721005992	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721005993	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721005994	integrase; Provisional; Region: PRK09692
232721005995	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
232721005996	active site
232721005997	Int/Topo IB signature motif; other site
232721005998	succinic semialdehyde dehydrogenase; Region: PLN02278
232721005999	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
232721006000	tetramerization interface [polypeptide binding]; other site
232721006001	NAD(P) binding site [chemical binding]; other site
232721006002	catalytic residues [active]
232721006003	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
232721006004	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
232721006005	motif 1; other site
232721006006	active site
232721006007	motif 2; other site
232721006008	motif 3; other site
232721006009	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
232721006010	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721006011	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721006012	metal binding site [ion binding]; metal-binding site
232721006013	active site
232721006014	I-site; other site
232721006015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721006016	S-adenosylmethionine binding site [chemical binding]; other site
232721006017	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
232721006018	active site
232721006019	HIGH motif; other site
232721006020	nucleotide binding site [chemical binding]; other site
232721006021	active site
232721006022	KMSKS motif; other site
232721006023	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
232721006024	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
232721006025	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
232721006026	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721006027	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721006028	dimerization interface [polypeptide binding]; other site
232721006029	Pirin-related protein [General function prediction only]; Region: COG1741
232721006030	Pirin; Region: Pirin; pfam02678
232721006031	DoxX; Region: DoxX; cl17842
232721006032	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
232721006033	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
232721006034	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
232721006035	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
232721006036	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
232721006037	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
232721006038	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
232721006039	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
232721006040	active site
232721006041	tetramer interface [polypeptide binding]; other site
232721006042	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
232721006043	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
232721006044	putative ligand binding site [chemical binding]; other site
232721006045	NAD binding site [chemical binding]; other site
232721006046	catalytic site [active]
232721006047	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721006048	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
232721006049	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
232721006050	putative active site [active]
232721006051	catalytic residue [active]
232721006052	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721006053	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
232721006054	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
232721006055	DNA-binding site [nucleotide binding]; DNA binding site
232721006056	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
232721006057	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
232721006058	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
232721006059	active site
232721006060	tetramer interface [polypeptide binding]; other site
232721006061	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721006062	galactarate dehydratase; Region: galactar-dH20; TIGR03248
232721006063	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
232721006064	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
232721006065	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
232721006066	Protein with unknown function (DUF469); Region: DUF469; pfam04320
232721006067	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
232721006068	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
232721006069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721006070	catalytic residue [active]
232721006071	Transposase domain (DUF772); Region: DUF772; pfam05598
232721006072	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721006073	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721006074	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
232721006075	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
232721006076	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721006077	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721006078	active site
232721006079	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
232721006080	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
232721006081	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
232721006082	tetrameric interface [polypeptide binding]; other site
232721006083	NAD binding site [chemical binding]; other site
232721006084	catalytic residues [active]
232721006085	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721006086	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721006087	LysR substrate binding domain; Region: LysR_substrate; pfam03466
232721006088	dimerization interface [polypeptide binding]; other site
232721006089	FOG: CBS domain [General function prediction only]; Region: COG0517
232721006090	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
232721006091	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
232721006092	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
232721006093	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
232721006094	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
232721006095	Isochorismatase family; Region: Isochorismatase; pfam00857
232721006096	catalytic triad [active]
232721006097	dimer interface [polypeptide binding]; other site
232721006098	conserved cis-peptide bond; other site
232721006099	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
232721006100	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721006101	acyl-activating enzyme (AAE) consensus motif; other site
232721006102	AMP binding site [chemical binding]; other site
232721006103	active site
232721006104	CoA binding site [chemical binding]; other site
232721006105	PAS fold; Region: PAS_3; pfam08447
232721006106	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
232721006107	PAS domain S-box; Region: sensory_box; TIGR00229
232721006108	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721006109	putative active site [active]
232721006110	heme pocket [chemical binding]; other site
232721006111	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721006112	PAS fold; Region: PAS_3; pfam08447
232721006113	putative active site [active]
232721006114	heme pocket [chemical binding]; other site
232721006115	PAS domain S-box; Region: sensory_box; TIGR00229
232721006116	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721006117	putative active site [active]
232721006118	heme pocket [chemical binding]; other site
232721006119	PAS fold; Region: PAS_3; pfam08447
232721006120	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721006121	metal binding site [ion binding]; metal-binding site
232721006122	active site
232721006123	I-site; other site
232721006124	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
232721006125	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
232721006126	EamA-like transporter family; Region: EamA; pfam00892
232721006127	EamA-like transporter family; Region: EamA; pfam00892
232721006128	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
232721006129	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
232721006130	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
232721006131	DNA binding site [nucleotide binding]
232721006132	active site
232721006133	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
232721006134	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
232721006135	Helix-turn-helix domain; Region: HTH_18; pfam12833
232721006136	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
232721006137	AlkA N-terminal domain; Region: AlkA_N; pfam06029
232721006138	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
232721006139	minor groove reading motif; other site
232721006140	helix-hairpin-helix signature motif; other site
232721006141	active site
232721006142	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
232721006143	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
232721006144	active site
232721006145	substrate binding site [chemical binding]; other site
232721006146	metal binding site [ion binding]; metal-binding site
232721006147	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
232721006148	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
232721006149	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
232721006150	CoA binding domain; Region: CoA_binding_2; pfam13380
232721006151	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
232721006152	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
232721006153	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
232721006154	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
232721006155	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
232721006156	hypothetical protein; Provisional; Region: PRK09272
232721006157	RibD C-terminal domain; Region: RibD_C; cl17279
232721006158	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
232721006159	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
232721006160	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
232721006161	active site residue [active]
232721006162	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
232721006163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721006164	S-adenosylmethionine binding site [chemical binding]; other site
232721006165	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
232721006166	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721006167	methionine sulfoxide reductase A; Provisional; Region: PRK14054
232721006168	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
232721006169	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
232721006170	Protein of unknown function (DUF342); Region: DUF342; pfam03961
232721006171	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
232721006172	Chromate transporter; Region: Chromate_transp; pfam02417
232721006173	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721006174	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
232721006175	AsnC family; Region: AsnC_trans_reg; pfam01037
232721006176	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
232721006177	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
232721006178	NAD(P) binding pocket [chemical binding]; other site
232721006179	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
232721006180	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
232721006181	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
232721006182	acyl-activating enzyme (AAE) consensus motif; other site
232721006183	putative AMP binding site [chemical binding]; other site
232721006184	putative active site [active]
232721006185	putative CoA binding site [chemical binding]; other site
232721006186	Transcriptional regulators [Transcription]; Region: GntR; COG1802
232721006187	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
232721006188	DNA-binding site [nucleotide binding]; DNA binding site
232721006189	FCD domain; Region: FCD; pfam07729
232721006190	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
232721006191	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
232721006192	active site
232721006193	substrate binding site [chemical binding]; other site
232721006194	coenzyme B12 binding site [chemical binding]; other site
232721006195	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
232721006196	B12 binding site [chemical binding]; other site
232721006197	cobalt ligand [ion binding]; other site
232721006198	ArgK protein; Region: ArgK; pfam03308
232721006199	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
232721006200	Walker A; other site
232721006201	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
232721006202	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
232721006203	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
232721006204	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
232721006205	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
232721006206	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
232721006207	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
232721006208	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
232721006209	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
232721006210	carboxyltransferase (CT) interaction site; other site
232721006211	biotinylation site [posttranslational modification]; other site
232721006212	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
232721006213	dimer interface [polypeptide binding]; other site
232721006214	substrate binding site [chemical binding]; other site
232721006215	metal binding site [ion binding]; metal-binding site
232721006216	biotin synthase; Region: bioB; TIGR00433
232721006217	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
232721006218	FeS/SAM binding site; other site
232721006219	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
232721006220	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
232721006221	classical (c) SDRs; Region: SDR_c; cd05233
232721006222	NAD(P) binding site [chemical binding]; other site
232721006223	active site
232721006224	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
232721006225	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
232721006226	dimer interface [polypeptide binding]; other site
232721006227	active site
232721006228	metal binding site [ion binding]; metal-binding site
232721006229	glutathione binding site [chemical binding]; other site
232721006230	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
232721006231	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
232721006232	active site
232721006233	intersubunit interface [polypeptide binding]; other site
232721006234	catalytic residue [active]
232721006235	phosphogluconate dehydratase; Validated; Region: PRK09054
232721006236	6-phosphogluconate dehydratase; Region: edd; TIGR01196
232721006237	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
232721006238	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
232721006239	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
232721006240	DctM-like transporters; Region: DctM; pfam06808
232721006241	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
232721006242	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
232721006243	ATP-binding site [chemical binding]; other site
232721006244	Gluconate-6-phosphate binding site [chemical binding]; other site
232721006245	Transcriptional regulators [Transcription]; Region: PurR; COG1609
232721006246	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
232721006247	DNA binding site [nucleotide binding]
232721006248	domain linker motif; other site
232721006249	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
232721006250	putative ligand binding site [chemical binding]; other site
232721006251	putative dimerization interface [polypeptide binding]; other site
232721006252	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
232721006253	ligand binding site [chemical binding]; other site
232721006254	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
232721006255	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
232721006256	putative active site pocket [active]
232721006257	dimerization interface [polypeptide binding]; other site
232721006258	putative catalytic residue [active]
232721006259	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
232721006260	E-class dimer interface [polypeptide binding]; other site
232721006261	P-class dimer interface [polypeptide binding]; other site
232721006262	active site
232721006263	Cu2+ binding site [ion binding]; other site
232721006264	Zn2+ binding site [ion binding]; other site
232721006265	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
232721006266	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
232721006267	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
232721006268	Membrane transport protein; Region: Mem_trans; cl09117
232721006269	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
232721006270	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
232721006271	FMN binding site [chemical binding]; other site
232721006272	active site
232721006273	catalytic residues [active]
232721006274	substrate binding site [chemical binding]; other site
232721006275	CHASE domain; Region: CHASE; pfam03924
232721006276	PAS fold; Region: PAS_4; pfam08448
232721006277	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721006278	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721006279	metal binding site [ion binding]; metal-binding site
232721006280	active site
232721006281	I-site; other site
232721006282	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
232721006283	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
232721006284	synthetase active site [active]
232721006285	NTP binding site [chemical binding]; other site
232721006286	metal binding site [ion binding]; metal-binding site
232721006287	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
232721006288	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
232721006289	ferredoxin; Provisional; Region: PRK08764
232721006290	Putative Fe-S cluster; Region: FeS; cl17515
232721006291	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
232721006292	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721006293	dimerization interface [polypeptide binding]; other site
232721006294	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721006295	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721006296	dimer interface [polypeptide binding]; other site
232721006297	putative CheW interface [polypeptide binding]; other site
232721006298	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
232721006299	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721006300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721006301	homodimer interface [polypeptide binding]; other site
232721006302	catalytic residue [active]
232721006303	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
232721006304	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
232721006305	active site
232721006306	substrate binding site [chemical binding]; other site
232721006307	trimer interface [polypeptide binding]; other site
232721006308	CoA binding site [chemical binding]; other site
232721006309	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
232721006310	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
232721006311	Walker A motif; other site
232721006312	ATP binding site [chemical binding]; other site
232721006313	Walker B motif; other site
232721006314	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
232721006315	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
232721006316	metal binding site [ion binding]; metal-binding site
232721006317	dimer interface [polypeptide binding]; other site
232721006318	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
232721006319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721006320	S-adenosylmethionine binding site [chemical binding]; other site
232721006321	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
232721006322	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
232721006323	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
232721006324	ABC transporter; Region: ABC_tran_2; pfam12848
232721006325	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
232721006326	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
232721006327	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
232721006328	NAD(P) binding site [chemical binding]; other site
232721006329	homotetramer interface [polypeptide binding]; other site
232721006330	homodimer interface [polypeptide binding]; other site
232721006331	active site
232721006332	putative acyltransferase; Provisional; Region: PRK05790
232721006333	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721006334	dimer interface [polypeptide binding]; other site
232721006335	active site
232721006336	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
232721006337	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
232721006338	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
232721006339	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
232721006340	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
232721006341	maleylacetoacetate isomerase; Region: maiA; TIGR01262
232721006342	C-terminal domain interface [polypeptide binding]; other site
232721006343	GSH binding site (G-site) [chemical binding]; other site
232721006344	putative dimer interface [polypeptide binding]; other site
232721006345	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
232721006346	N-terminal domain interface [polypeptide binding]; other site
232721006347	dimer interface [polypeptide binding]; other site
232721006348	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
232721006349	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
232721006350	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
232721006351	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
232721006352	nudix motif; other site
232721006353	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721006354	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721006355	putative substrate translocation pore; other site
232721006356	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
232721006357	Transglycosylase; Region: Transgly; pfam00912
232721006358	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
232721006359	hypothetical protein; Provisional; Region: PRK10279
232721006360	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
232721006361	nucleophile elbow; other site
232721006362	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
232721006363	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
232721006364	nucleotide binding pocket [chemical binding]; other site
232721006365	K-X-D-G motif; other site
232721006366	catalytic site [active]
232721006367	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
232721006368	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
232721006369	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
232721006370	Dimer interface [polypeptide binding]; other site
232721006371	BRCT sequence motif; other site
232721006372	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
232721006373	active site
232721006374	metal binding site [ion binding]; metal-binding site
232721006375	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
232721006376	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
232721006377	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
232721006378	Walker A/P-loop; other site
232721006379	ATP binding site [chemical binding]; other site
232721006380	Q-loop/lid; other site
232721006381	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
232721006382	Q-loop/lid; other site
232721006383	ABC transporter signature motif; other site
232721006384	Walker B; other site
232721006385	D-loop; other site
232721006386	H-loop/switch region; other site
232721006387	hypothetical protein; Provisional; Region: PRK02237
232721006388	CHASE domain; Region: CHASE; pfam03924
232721006389	PAS domain S-box; Region: sensory_box; TIGR00229
232721006390	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721006391	putative active site [active]
232721006392	heme pocket [chemical binding]; other site
232721006393	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721006394	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721006395	metal binding site [ion binding]; metal-binding site
232721006396	active site
232721006397	I-site; other site
232721006398	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
232721006399	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
232721006400	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
232721006401	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
232721006402	Walker A/P-loop; other site
232721006403	ATP binding site [chemical binding]; other site
232721006404	Q-loop/lid; other site
232721006405	ABC transporter signature motif; other site
232721006406	Walker B; other site
232721006407	D-loop; other site
232721006408	H-loop/switch region; other site
232721006409	putative transporter; Provisional; Region: PRK10504
232721006410	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721006411	putative substrate translocation pore; other site
232721006412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721006413	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
232721006414	NlpC/P60 family; Region: NLPC_P60; pfam00877
232721006415	EVE domain; Region: EVE; cl00728
232721006416	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
232721006417	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
232721006418	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
232721006419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
232721006420	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
232721006421	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
232721006422	E3 interaction surface; other site
232721006423	lipoyl attachment site [posttranslational modification]; other site
232721006424	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
232721006425	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
232721006426	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721006427	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
232721006428	6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240
232721006429	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
232721006430	putative NAD(P) binding site [chemical binding]; other site
232721006431	catalytic Zn binding site [ion binding]; other site
232721006432	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
232721006433	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
232721006434	homotetramer interface [polypeptide binding]; other site
232721006435	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
232721006436	NAD binding site [chemical binding]; other site
232721006437	homodimer interface [polypeptide binding]; other site
232721006438	active site
232721006439	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
232721006440	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
232721006441	Transposase; Region: DDE_Tnp_ISL3; pfam01610
232721006442	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
232721006443	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
232721006444	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
232721006445	dimer interface [polypeptide binding]; other site
232721006446	FMN binding site [chemical binding]; other site
232721006447	MgtC family; Region: MgtC; pfam02308
232721006448	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
232721006449	Putative transposase; Region: Y2_Tnp; pfam04986
232721006450	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
232721006451	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
232721006452	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
232721006453	cystine transporter subunit; Provisional; Region: PRK11260
232721006454	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
232721006455	substrate binding pocket [chemical binding]; other site
232721006456	membrane-bound complex binding site; other site
232721006457	hinge residues; other site
232721006458	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
232721006459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721006460	dimer interface [polypeptide binding]; other site
232721006461	conserved gate region; other site
232721006462	putative PBP binding loops; other site
232721006463	ABC-ATPase subunit interface; other site
232721006464	Uncharacterized conserved protein [Function unknown]; Region: COG1683
232721006465	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
232721006466	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
232721006467	Predicted transcriptional regulator [Transcription]; Region: COG1959
232721006468	Transcriptional regulator; Region: Rrf2; pfam02082
232721006469	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
232721006470	Putative transposase; Region: Y2_Tnp; pfam04986
232721006471	Transposase domain (DUF772); Region: DUF772; pfam05598
232721006472	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721006473	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721006474	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
232721006475	E3 interaction surface; other site
232721006476	lipoyl attachment site [posttranslational modification]; other site
232721006477	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
232721006478	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
232721006479	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721006480	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
232721006481	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
232721006482	E3 interaction surface; other site
232721006483	lipoyl attachment site [posttranslational modification]; other site
232721006484	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
232721006485	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
232721006486	E3 interaction surface; other site
232721006487	lipoyl attachment site [posttranslational modification]; other site
232721006488	e3 binding domain; Region: E3_binding; pfam02817
232721006489	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
232721006490	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
232721006491	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
232721006492	dimer interface [polypeptide binding]; other site
232721006493	TPP-binding site [chemical binding]; other site
232721006494	PAS domain S-box; Region: sensory_box; TIGR00229
232721006495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721006496	putative active site [active]
232721006497	heme pocket [chemical binding]; other site
232721006498	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721006499	dimer interface [polypeptide binding]; other site
232721006500	phosphorylation site [posttranslational modification]
232721006501	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721006502	ATP binding site [chemical binding]; other site
232721006503	Mg2+ binding site [ion binding]; other site
232721006504	G-X-G motif; other site
232721006505	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
232721006506	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721006507	active site
232721006508	phosphorylation site [posttranslational modification]
232721006509	intermolecular recognition site; other site
232721006510	dimerization interface [polypeptide binding]; other site
232721006511	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
232721006512	DNA binding residues [nucleotide binding]
232721006513	dimerization interface [polypeptide binding]; other site
232721006514	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
232721006515	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
232721006516	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
232721006517	homodimer interface [polypeptide binding]; other site
232721006518	NADP binding site [chemical binding]; other site
232721006519	substrate binding site [chemical binding]; other site
232721006520	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
232721006521	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
232721006522	active site
232721006523	Zn binding site [ion binding]; other site
232721006524	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
232721006525	catalytic residues [active]
232721006526	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
232721006527	tetramer (dimer of dimers) interface [polypeptide binding]; other site
232721006528	active site
232721006529	dimer interface [polypeptide binding]; other site
232721006530	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
232721006531	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
232721006532	quinone interaction residues [chemical binding]; other site
232721006533	active site
232721006534	catalytic residues [active]
232721006535	FMN binding site [chemical binding]; other site
232721006536	substrate binding site [chemical binding]; other site
232721006537	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
232721006538	hydroxyglutarate oxidase; Provisional; Region: PRK11728
232721006539	Predicted dehydrogenase [General function prediction only]; Region: COG0579
232721006540	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
232721006541	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
232721006542	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
232721006543	active site
232721006544	Zn binding site [ion binding]; other site
232721006545	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
232721006546	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
232721006547	active site
232721006548	catalytic site [active]
232721006549	substrate binding site [chemical binding]; other site
232721006550	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
232721006551	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
232721006552	catalytic loop [active]
232721006553	iron binding site [ion binding]; other site
232721006554	chaperone protein HscA; Provisional; Region: hscA; PRK05183
232721006555	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
232721006556	nucleotide binding site [chemical binding]; other site
232721006557	putative NEF/HSP70 interaction site [polypeptide binding]; other site
232721006558	SBD interface [polypeptide binding]; other site
232721006559	co-chaperone HscB; Provisional; Region: hscB; PRK03578
232721006560	DnaJ domain; Region: DnaJ; pfam00226
232721006561	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
232721006562	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
232721006563	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
232721006564	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
232721006565	trimerization site [polypeptide binding]; other site
232721006566	active site
232721006567	cysteine desulfurase; Provisional; Region: PRK14012
232721006568	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
232721006569	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721006570	catalytic residue [active]
232721006571	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
232721006572	Rrf2 family protein; Region: rrf2_super; TIGR00738
232721006573	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721006574	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721006575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721006576	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
232721006577	Transposase; Region: DDE_Tnp_ISL3; pfam01610
232721006578	Homeodomain-like domain; Region: HTH_23; pfam13384
232721006579	Winged helix-turn helix; Region: HTH_29; pfam13551
232721006580	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
232721006581	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721006582	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721006583	excinuclease ABC subunit B; Provisional; Region: PRK05298
232721006584	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721006585	ATP binding site [chemical binding]; other site
232721006586	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721006587	nucleotide binding region [chemical binding]; other site
232721006588	ATP-binding site [chemical binding]; other site
232721006589	Ultra-violet resistance protein B; Region: UvrB; pfam12344
232721006590	UvrB/uvrC motif; Region: UVR; pfam02151
232721006591	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
232721006592	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721006593	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721006594	homodimer interface [polypeptide binding]; other site
232721006595	catalytic residue [active]
232721006596	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
232721006597	Tar ligand binding domain homologue; Region: TarH; pfam02203
232721006598	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721006599	dimerization interface [polypeptide binding]; other site
232721006600	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721006601	dimer interface [polypeptide binding]; other site
232721006602	putative CheW interface [polypeptide binding]; other site
232721006603	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
232721006604	CoA-transferase family III; Region: CoA_transf_3; pfam02515
232721006605	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
232721006606	Transposase, Mutator family; Region: Transposase_mut; pfam00872
232721006607	MULE transposase domain; Region: MULE; pfam10551
232721006608	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
232721006609	Helix-turn-helix domain; Region: HTH_38; pfam13936
232721006610	Integrase core domain; Region: rve; pfam00665
232721006611	Short C-terminal domain; Region: SHOCT; pfam09851
232721006612	Methyltransferase domain; Region: Methyltransf_23; pfam13489
232721006613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721006614	S-adenosylmethionine binding site [chemical binding]; other site
232721006615	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
232721006616	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721006617	motif II; other site
232721006618	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
232721006619	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
232721006620	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
232721006621	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
232721006622	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
232721006623	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
232721006624	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
232721006625	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
232721006626	D-Lactate and related Dehydrogenase like proteins, NAD-binding and catalytic domains; Region: LDH_like_1; cd12187
232721006627	ligand binding site [chemical binding]; other site
232721006628	NAD binding site [chemical binding]; other site
232721006629	homodimer interface [polypeptide binding]; other site
232721006630	catalytic site [active]
232721006631	phosphoenolpyruvate synthase; Validated; Region: PRK06464
232721006632	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
232721006633	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
232721006634	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
232721006635	glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207
232721006636	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
232721006637	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
232721006638	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721006639	LysR substrate binding domain; Region: LysR_substrate; pfam03466
232721006640	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721006641	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
232721006642	Integrase core domain; Region: rve; pfam00665
232721006643	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
232721006644	Bacterial TniB protein; Region: TniB; pfam05621
232721006645	AAA domain; Region: AAA_22; pfam13401
232721006646	TniQ; Region: TniQ; pfam06527
232721006647	Helix-turn-helix domain; Region: HTH_28; pfam13518
232721006648	Winged helix-turn helix; Region: HTH_29; pfam13551
232721006649	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
232721006650	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721006651	non-specific DNA binding site [nucleotide binding]; other site
232721006652	salt bridge; other site
232721006653	sequence-specific DNA binding site [nucleotide binding]; other site
232721006654	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
232721006655	Putative helicase; Region: TraI_2; pfam07514
232721006656	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
232721006657	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
232721006658	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
232721006659	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
232721006660	Protein of unknown function (DUF3742); Region: DUF3742; pfam12553
232721006661	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
232721006662	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
232721006663	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
232721006664	Protein of unknown function (DUF1525); Region: DUF1525; pfam07511
232721006665	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
232721006666	MPN+ (JAMM) motif; other site
232721006667	Zinc-binding site [ion binding]; other site
232721006668	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
232721006669	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
232721006670	catalytic residues [active]
232721006671	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
232721006672	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
232721006673	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
232721006674	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
232721006675	Protein of unknown function (DUF904); Region: DUF904; pfam06005
232721006676	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
232721006677	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
232721006678	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
232721006679	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
232721006680	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
232721006681	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
232721006682	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
232721006683	DNA binding domain, excisionase family; Region: excise; TIGR01764
232721006684	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
232721006685	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
232721006686	cofactor binding site; other site
232721006687	DNA binding site [nucleotide binding]
232721006688	substrate interaction site [chemical binding]; other site
232721006689	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
232721006690	putative active site [active]
232721006691	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721006692	ATP binding site [chemical binding]; other site
232721006693	putative Mg++ binding site [ion binding]; other site
232721006694	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721006695	nucleotide binding region [chemical binding]; other site
232721006696	ATP-binding site [chemical binding]; other site
232721006697	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
232721006698	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
232721006699	Transposase; Region: DDE_Tnp_ISL3; pfam01610
232721006700	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
232721006701	ATP binding site [chemical binding]; other site
232721006702	Mg2+ binding site [ion binding]; other site
232721006703	G-X-G motif; other site
232721006704	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721006705	ATP-binding site [chemical binding]; other site
232721006706	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
232721006707	Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132
232721006708	PLD-like domain; Region: PLDc_2; pfam13091
232721006709	putative active site [active]
232721006710	putative catalytic site [active]
232721006711	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
232721006712	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
232721006713	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
232721006714	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
232721006715	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
232721006716	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
232721006717	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721006718	non-specific DNA binding site [nucleotide binding]; other site
232721006719	salt bridge; other site
232721006720	sequence-specific DNA binding site [nucleotide binding]; other site
232721006721	Predicted ATPase [General function prediction only]; Region: COG5293
232721006722	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
232721006723	TIR domain; Region: TIR_2; pfam13676
232721006724	AAA ATPase domain; Region: AAA_16; pfam13191
232721006725	TPR repeat; Region: TPR_11; pfam13414
232721006726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
232721006727	TPR motif; other site
232721006728	binding surface
232721006729	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
232721006730	binding surface
232721006731	TPR repeat; Region: TPR_11; pfam13414
232721006732	TPR motif; other site
232721006733	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
232721006734	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
232721006735	putative active site [active]
232721006736	putative NTP binding site [chemical binding]; other site
232721006737	putative nucleic acid binding site [nucleotide binding]; other site
232721006738	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
232721006739	DEAD-like helicases superfamily; Region: DEXDc; smart00487
232721006740	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721006741	nucleotide binding region [chemical binding]; other site
232721006742	ATP-binding site [chemical binding]; other site
232721006743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721006744	S-adenosylmethionine binding site [chemical binding]; other site
232721006745	Protein of unknown function (DUF3275); Region: DUF3275; pfam11679
232721006746	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
232721006747	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
232721006748	DNA topoisomerase III; Provisional; Region: PRK07726
232721006749	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
232721006750	active site
232721006751	putative interdomain interaction site [polypeptide binding]; other site
232721006752	putative metal-binding site [ion binding]; other site
232721006753	putative nucleotide binding site [chemical binding]; other site
232721006754	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
232721006755	domain I; other site
232721006756	DNA binding groove [nucleotide binding]
232721006757	phosphate binding site [ion binding]; other site
232721006758	domain II; other site
232721006759	domain III; other site
232721006760	nucleotide binding site [chemical binding]; other site
232721006761	catalytic site [active]
232721006762	domain IV; other site
232721006763	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
232721006764	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
232721006765	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
232721006766	dimer interface [polypeptide binding]; other site
232721006767	ssDNA binding site [nucleotide binding]; other site
232721006768	tetramer (dimer of dimers) interface [polypeptide binding]; other site
232721006769	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
232721006770	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
232721006771	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
232721006772	RelB antitoxin; Region: RelB; cl01171
232721006773	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
232721006774	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
232721006775	hypothetical protein; Provisional; Region: PRK01254
232721006776	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
232721006777	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
232721006778	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
232721006779	Uncharacterized conserved protein [Function unknown]; Region: COG1739
232721006780	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
232721006781	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
232721006782	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
232721006783	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721006784	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
232721006785	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
232721006786	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
232721006787	Amidase; Region: Amidase; pfam01425
232721006788	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721006789	D-serine dehydratase; Provisional; Region: PRK02991
232721006790	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
232721006791	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721006792	catalytic residue [active]
232721006793	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
232721006794	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721006795	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721006796	dimerization interface [polypeptide binding]; other site
232721006797	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721006798	non-specific DNA binding site [nucleotide binding]; other site
232721006799	salt bridge; other site
232721006800	sequence-specific DNA binding site [nucleotide binding]; other site
232721006801	HipA N-terminal domain; Region: Couple_hipA; pfam13657
232721006802	HipA-like N-terminal domain; Region: HipA_N; pfam07805
232721006803	HipA-like C-terminal domain; Region: HipA_C; pfam07804
232721006804	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721006805	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721006806	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
232721006807	putative dimerization interface [polypeptide binding]; other site
232721006808	Domain of unknown function (DUF897); Region: DUF897; cl01312
232721006809	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
232721006810	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
232721006811	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
232721006812	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
232721006813	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
232721006814	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
232721006815	Chromate transporter; Region: Chromate_transp; pfam02417
232721006816	Chromate transporter; Region: Chromate_transp; pfam02417
232721006817	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
232721006818	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
232721006819	NAD-dependent deacetylase; Provisional; Region: PRK00481
232721006820	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
232721006821	NAD+ binding site [chemical binding]; other site
232721006822	substrate binding site [chemical binding]; other site
232721006823	Zn binding site [ion binding]; other site
232721006824	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
232721006825	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721006826	WHG domain; Region: WHG; pfam13305
232721006827	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
232721006828	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
232721006829	dimer interface [polypeptide binding]; other site
232721006830	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
232721006831	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
232721006832	putative hydrophobic ligand binding site [chemical binding]; other site
232721006833	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
232721006834	dimer interface [polypeptide binding]; other site
232721006835	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
232721006836	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
232721006837	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
232721006838	serine/threonine transporter SstT; Provisional; Region: PRK13628
232721006839	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
232721006840	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
232721006841	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
232721006842	Walker A/P-loop; other site
232721006843	ATP binding site [chemical binding]; other site
232721006844	Q-loop/lid; other site
232721006845	ABC transporter signature motif; other site
232721006846	Walker B; other site
232721006847	D-loop; other site
232721006848	H-loop/switch region; other site
232721006849	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
232721006850	active site
232721006851	catalytic triad [active]
232721006852	oxyanion hole [active]
232721006853	switch loop; other site
232721006854	Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955
232721006855	cystathionine beta-lyase; Provisional; Region: PRK07050
232721006856	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
232721006857	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721006858	catalytic residue [active]
232721006859	BON domain; Region: BON; pfam04972
232721006860	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
232721006861	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
232721006862	Sulfate transporter family; Region: Sulfate_transp; pfam00916
232721006863	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
232721006864	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721006865	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721006866	metal binding site [ion binding]; metal-binding site
232721006867	active site
232721006868	I-site; other site
232721006869	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
232721006870	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
232721006871	P-loop; other site
232721006872	ADP binding residues [chemical binding]; other site
232721006873	Switch I; other site
232721006874	Switch II; other site
232721006875	Pirin-related protein [General function prediction only]; Region: COG1741
232721006876	Pirin; Region: Pirin; pfam02678
232721006877	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
232721006878	OsmC-like protein; Region: OsmC; pfam02566
232721006879	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
232721006880	dimer interface [polypeptide binding]; other site
232721006881	catalytic triad [active]
232721006882	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
232721006883	nucleoside/Zn binding site; other site
232721006884	dimer interface [polypeptide binding]; other site
232721006885	catalytic motif [active]
232721006886	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
232721006887	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
232721006888	Peptidase family U32; Region: Peptidase_U32; pfam01136
232721006889	Collagenase; Region: DUF3656; pfam12392
232721006890	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
232721006891	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
232721006892	homodimer interface [polypeptide binding]; other site
232721006893	substrate-cofactor binding pocket; other site
232721006894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721006895	catalytic residue [active]
232721006896	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
232721006897	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
232721006898	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
232721006899	Methyltransferase domain; Region: Methyltransf_25; pfam13649
232721006900	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
232721006901	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
232721006902	Protein of unknown function (DUF808); Region: DUF808; pfam05661
232721006903	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
232721006904	active site
232721006905	PII uridylyl-transferase; Provisional; Region: PRK03059
232721006906	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
232721006907	metal binding triad; other site
232721006908	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
232721006909	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
232721006910	Zn2+ binding site [ion binding]; other site
232721006911	Mg2+ binding site [ion binding]; other site
232721006912	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
232721006913	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
232721006914	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
232721006915	active site
232721006916	catalytic residues [active]
232721006917	metal binding site [ion binding]; metal-binding site
232721006918	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
232721006919	isocitrate dehydrogenase; Validated; Region: PRK07362
232721006920	isocitrate dehydrogenase; Reviewed; Region: PRK07006
232721006921	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
232721006922	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
232721006923	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
232721006924	superoxide dismutase; Provisional; Region: PRK10543
232721006925	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
232721006926	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
232721006927	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
232721006928	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
232721006929	generic binding surface II; other site
232721006930	generic binding surface I; other site
232721006931	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
232721006932	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
232721006933	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
232721006934	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
232721006935	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
232721006936	Uncharacterized conserved protein [Function unknown]; Region: COG2835
232721006937	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
232721006938	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
232721006939	Ligand binding site; other site
232721006940	oligomer interface; other site
232721006941	adenylate kinase; Reviewed; Region: adk; PRK00279
232721006942	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
232721006943	AMP-binding site [chemical binding]; other site
232721006944	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
232721006945	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
232721006946	active site
232721006947	homotetramer interface [polypeptide binding]; other site
232721006948	homodimer interface [polypeptide binding]; other site
232721006949	LexA repressor; Validated; Region: PRK00215
232721006950	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
232721006951	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
232721006952	Catalytic site [active]
232721006953	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
232721006954	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
232721006955	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721006956	ATP binding site [chemical binding]; other site
232721006957	putative Mg++ binding site [ion binding]; other site
232721006958	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721006959	nucleotide binding region [chemical binding]; other site
232721006960	ATP-binding site [chemical binding]; other site
232721006961	Helicase associated domain (HA2); Region: HA2; pfam04408
232721006962	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
232721006963	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
232721006964	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
232721006965	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
232721006966	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
232721006967	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
232721006968	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
232721006969	putative active site [active]
232721006970	putative metal binding site [ion binding]; other site
232721006971	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
232721006972	FMN binding site [chemical binding]; other site
232721006973	dimer interface [polypeptide binding]; other site
232721006974	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721006975	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
232721006976	dimer interface [polypeptide binding]; other site
232721006977	active site
232721006978	acyl-CoA synthetase; Validated; Region: PRK07788
232721006979	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721006980	acyl-activating enzyme (AAE) consensus motif; other site
232721006981	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721006982	AMP binding site [chemical binding]; other site
232721006983	active site
232721006984	acyl-activating enzyme (AAE) consensus motif; other site
232721006985	CoA binding site [chemical binding]; other site
232721006986	BioY family; Region: BioY; pfam02632
232721006987	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
232721006988	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
232721006989	Walker A/P-loop; other site
232721006990	ATP binding site [chemical binding]; other site
232721006991	Q-loop/lid; other site
232721006992	ABC transporter signature motif; other site
232721006993	Walker B; other site
232721006994	D-loop; other site
232721006995	H-loop/switch region; other site
232721006996	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721006997	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721006998	putative substrate translocation pore; other site
232721006999	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
232721007000	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
232721007001	Methyltransferase domain; Region: Methyltransf_23; pfam13489
232721007002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721007003	S-adenosylmethionine binding site [chemical binding]; other site
232721007004	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721007005	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
232721007006	N-acetylglutamate synthase; Validated; Region: PRK05279
232721007007	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
232721007008	putative feedback inhibition sensing region; other site
232721007009	putative nucleotide binding site [chemical binding]; other site
232721007010	putative substrate binding site [chemical binding]; other site
232721007011	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
232721007012	Coenzyme A binding pocket [chemical binding]; other site
232721007013	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
232721007014	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
232721007015	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721007016	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721007017	dimerization interface [polypeptide binding]; other site
232721007018	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
232721007019	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
232721007020	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
232721007021	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
232721007022	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
232721007023	putative N-terminal domain interface [polypeptide binding]; other site
232721007024	putative dimer interface [polypeptide binding]; other site
232721007025	putative substrate binding pocket (H-site) [chemical binding]; other site
232721007026	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
232721007027	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
232721007028	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
232721007029	Walker A/P-loop; other site
232721007030	ATP binding site [chemical binding]; other site
232721007031	Q-loop/lid; other site
232721007032	ABC transporter signature motif; other site
232721007033	Walker B; other site
232721007034	D-loop; other site
232721007035	H-loop/switch region; other site
232721007036	TOBE-like domain; Region: TOBE_3; pfam12857
232721007037	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721007038	dimer interface [polypeptide binding]; other site
232721007039	conserved gate region; other site
232721007040	putative PBP binding loops; other site
232721007041	ABC-ATPase subunit interface; other site
232721007042	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
232721007043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721007044	dimer interface [polypeptide binding]; other site
232721007045	conserved gate region; other site
232721007046	putative PBP binding loops; other site
232721007047	ABC-ATPase subunit interface; other site
232721007048	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
232721007049	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
232721007050	LysR family transcriptional regulator; Provisional; Region: PRK14997
232721007051	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
232721007052	putative effector binding pocket; other site
232721007053	putative dimerization interface [polypeptide binding]; other site
232721007054	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
232721007055	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
232721007056	Predicted flavoprotein [General function prediction only]; Region: COG0431
232721007057	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
232721007058	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
232721007059	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
232721007060	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721007061	dimer interface [polypeptide binding]; other site
232721007062	conserved gate region; other site
232721007063	ABC-ATPase subunit interface; other site
232721007064	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
232721007065	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
232721007066	Walker A/P-loop; other site
232721007067	ATP binding site [chemical binding]; other site
232721007068	Q-loop/lid; other site
232721007069	ABC transporter signature motif; other site
232721007070	Walker B; other site
232721007071	D-loop; other site
232721007072	H-loop/switch region; other site
232721007073	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
232721007074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721007075	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721007076	putative substrate translocation pore; other site
232721007077	MAPEG family; Region: MAPEG; cl09190
232721007078	recombination protein RecR; Reviewed; Region: recR; PRK00076
232721007079	RecR protein; Region: RecR; pfam02132
232721007080	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
232721007081	putative active site [active]
232721007082	putative metal-binding site [ion binding]; other site
232721007083	tetramer interface [polypeptide binding]; other site
232721007084	hypothetical protein; Validated; Region: PRK00153
232721007085	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
232721007086	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721007087	Walker A motif; other site
232721007088	ATP binding site [chemical binding]; other site
232721007089	Walker B motif; other site
232721007090	arginine finger; other site
232721007091	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
232721007092	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
232721007093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721007094	S-adenosylmethionine binding site [chemical binding]; other site
232721007095	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
232721007096	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
232721007097	putative recombination protein RecB; Provisional; Region: PRK13909
232721007098	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
232721007099	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
232721007100	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
232721007101	catalytic residues [active]
232721007102	transcription termination factor Rho; Provisional; Region: rho; PRK09376
232721007103	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
232721007104	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
232721007105	RNA binding site [nucleotide binding]; other site
232721007106	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
232721007107	multimer interface [polypeptide binding]; other site
232721007108	Walker A motif; other site
232721007109	ATP binding site [chemical binding]; other site
232721007110	Walker B motif; other site
232721007111	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
232721007112	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
232721007113	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
232721007114	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721007115	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
232721007116	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
232721007117	Walker A/P-loop; other site
232721007118	ATP binding site [chemical binding]; other site
232721007119	Q-loop/lid; other site
232721007120	ABC transporter signature motif; other site
232721007121	Walker B; other site
232721007122	D-loop; other site
232721007123	H-loop/switch region; other site
232721007124	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
232721007125	Walker A/P-loop; other site
232721007126	ATP binding site [chemical binding]; other site
232721007127	Q-loop/lid; other site
232721007128	ABC transporter signature motif; other site
232721007129	Walker B; other site
232721007130	D-loop; other site
232721007131	H-loop/switch region; other site
232721007132	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
232721007133	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
232721007134	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
232721007135	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
232721007136	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
232721007137	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
232721007138	putative efflux protein, MATE family; Region: matE; TIGR00797
232721007139	cation binding site [ion binding]; other site
232721007140	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
232721007141	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721007142	putative active site [active]
232721007143	heme pocket [chemical binding]; other site
232721007144	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721007145	dimer interface [polypeptide binding]; other site
232721007146	phosphorylation site [posttranslational modification]
232721007147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721007148	ATP binding site [chemical binding]; other site
232721007149	Mg2+ binding site [ion binding]; other site
232721007150	G-X-G motif; other site
232721007151	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
232721007152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721007153	active site
232721007154	phosphorylation site [posttranslational modification]
232721007155	intermolecular recognition site; other site
232721007156	dimerization interface [polypeptide binding]; other site
232721007157	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721007158	DNA binding site [nucleotide binding]
232721007159	transcriptional regulator PhoU; Provisional; Region: PRK11115
232721007160	PhoU domain; Region: PhoU; pfam01895
232721007161	PhoU domain; Region: PhoU; pfam01895
232721007162	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
232721007163	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
232721007164	Walker A/P-loop; other site
232721007165	ATP binding site [chemical binding]; other site
232721007166	Q-loop/lid; other site
232721007167	ABC transporter signature motif; other site
232721007168	Walker B; other site
232721007169	D-loop; other site
232721007170	H-loop/switch region; other site
232721007171	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
232721007172	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721007173	dimer interface [polypeptide binding]; other site
232721007174	conserved gate region; other site
232721007175	putative PBP binding loops; other site
232721007176	ABC-ATPase subunit interface; other site
232721007177	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
232721007178	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721007179	dimer interface [polypeptide binding]; other site
232721007180	conserved gate region; other site
232721007181	putative PBP binding loops; other site
232721007182	ABC-ATPase subunit interface; other site
232721007183	PBP superfamily domain; Region: PBP_like_2; cl17296
232721007184	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
232721007185	Fasciclin domain; Region: Fasciclin; pfam02469
232721007186	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
232721007187	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
232721007188	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
232721007189	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
232721007190	Zn2+ binding site [ion binding]; other site
232721007191	Mg2+ binding site [ion binding]; other site
232721007192	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
232721007193	catalytic core [active]
232721007194	polyphosphate kinase; Provisional; Region: PRK05443
232721007195	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
232721007196	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
232721007197	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
232721007198	putative active site [active]
232721007199	catalytic site [active]
232721007200	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
232721007201	putative active site [active]
232721007202	catalytic site [active]
232721007203	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
232721007204	PAS domain S-box; Region: sensory_box; TIGR00229
232721007205	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721007206	putative active site [active]
232721007207	heme pocket [chemical binding]; other site
232721007208	PAS domain; Region: PAS_8; pfam13188
232721007209	PAS domain; Region: PAS_9; pfam13426
232721007210	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721007211	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721007212	metal binding site [ion binding]; metal-binding site
232721007213	active site
232721007214	I-site; other site
232721007215	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
232721007216	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
232721007217	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
232721007218	active site
232721007219	substrate binding site [chemical binding]; other site
232721007220	metal binding site [ion binding]; metal-binding site
232721007221	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
232721007222	dihydropteroate synthase; Region: DHPS; TIGR01496
232721007223	substrate binding pocket [chemical binding]; other site
232721007224	dimer interface [polypeptide binding]; other site
232721007225	inhibitor binding site; inhibition site
232721007226	FtsH Extracellular; Region: FtsH_ext; pfam06480
232721007227	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
232721007228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721007229	Walker A motif; other site
232721007230	ATP binding site [chemical binding]; other site
232721007231	Walker B motif; other site
232721007232	arginine finger; other site
232721007233	Peptidase family M41; Region: Peptidase_M41; pfam01434
232721007234	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
232721007235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721007236	S-adenosylmethionine binding site [chemical binding]; other site
232721007237	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
232721007238	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
232721007239	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
232721007240	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
232721007241	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
232721007242	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
232721007243	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
232721007244	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
232721007245	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
232721007246	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
232721007247	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
232721007248	ATP-grasp domain; Region: ATP-grasp_4; cl17255
232721007249	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
232721007250	IMP binding site; other site
232721007251	dimer interface [polypeptide binding]; other site
232721007252	interdomain contacts; other site
232721007253	partial ornithine binding site; other site
232721007254	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
232721007255	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
232721007256	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
232721007257	catalytic site [active]
232721007258	subunit interface [polypeptide binding]; other site
232721007259	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
232721007260	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
232721007261	DNA binding residues [nucleotide binding]
232721007262	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
232721007263	IHF - DNA interface [nucleotide binding]; other site
232721007264	IHF dimer interface [polypeptide binding]; other site
232721007265	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
232721007266	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
232721007267	putative tRNA-binding site [nucleotide binding]; other site
232721007268	B3/4 domain; Region: B3_4; pfam03483
232721007269	tRNA synthetase B5 domain; Region: B5; smart00874
232721007270	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
232721007271	dimer interface [polypeptide binding]; other site
232721007272	motif 1; other site
232721007273	motif 3; other site
232721007274	motif 2; other site
232721007275	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
232721007276	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
232721007277	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
232721007278	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
232721007279	dimer interface [polypeptide binding]; other site
232721007280	motif 1; other site
232721007281	active site
232721007282	motif 2; other site
232721007283	motif 3; other site
232721007284	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
232721007285	23S rRNA binding site [nucleotide binding]; other site
232721007286	L21 binding site [polypeptide binding]; other site
232721007287	L13 binding site [polypeptide binding]; other site
232721007288	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
232721007289	translation initiation factor IF-3; Region: infC; TIGR00168
232721007290	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
232721007291	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
232721007292	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
232721007293	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
232721007294	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
232721007295	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
232721007296	active site
232721007297	dimer interface [polypeptide binding]; other site
232721007298	motif 1; other site
232721007299	motif 2; other site
232721007300	motif 3; other site
232721007301	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
232721007302	anticodon binding site; other site
232721007303	isocitrate lyase; Provisional; Region: PRK15063
232721007304	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
232721007305	tetramer interface [polypeptide binding]; other site
232721007306	active site
232721007307	Mg2+/Mn2+ binding site [ion binding]; other site
232721007308	EamA-like transporter family; Region: EamA; pfam00892
232721007309	EamA-like transporter family; Region: EamA; pfam00892
232721007310	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
232721007311	SWIB/MDM2 domain; Region: SWIB; pfam02201
232721007312	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
232721007313	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
232721007314	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
232721007315	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
232721007316	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
232721007317	TolR protein; Region: tolR; TIGR02801
232721007318	Hemin uptake protein hemP; Region: hemP; pfam10636
232721007319	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
232721007320	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
232721007321	YccA-like proteins; Region: YccA_like; cd10433
232721007322	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
232721007323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
232721007324	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
232721007325	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
232721007326	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
232721007327	DNA binding residues [nucleotide binding]
232721007328	Heavy-metal resistance; Region: Metal_resist; pfam13801
232721007329	dimer interface [polypeptide binding]; other site
232721007330	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
232721007331	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721007332	putative DNA binding site [nucleotide binding]; other site
232721007333	putative Zn2+ binding site [ion binding]; other site
232721007334	AsnC family; Region: AsnC_trans_reg; pfam01037
232721007335	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
232721007336	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
232721007337	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
232721007338	NAD(P) binding site [chemical binding]; other site
232721007339	catalytic residues [active]
232721007340	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
232721007341	tetrathionate reductase subunit B; Provisional; Region: PRK14993
232721007342	4Fe-4S binding domain; Region: Fer4; pfam00037
232721007343	tetrathionate reductase subunit C; Provisional; Region: PRK14992
232721007344	tetrathionate reductase subunit A; Provisional; Region: PRK14991
232721007345	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
232721007346	molybdopterin cofactor binding site; other site
232721007347	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
232721007348	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
232721007349	putative molybdopterin cofactor binding site; other site
232721007350	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
232721007351	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721007352	ATP binding site [chemical binding]; other site
232721007353	putative Mg++ binding site [ion binding]; other site
232721007354	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
232721007355	Protein of unknown function (DUF3223); Region: DUF3223; pfam11523
232721007356	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
232721007357	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
232721007358	This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990
232721007359	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
232721007360	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
232721007361	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
232721007362	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
232721007363	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721007364	active site
232721007365	phosphorylation site [posttranslational modification]
232721007366	intermolecular recognition site; other site
232721007367	dimerization interface [polypeptide binding]; other site
232721007368	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721007369	DNA binding site [nucleotide binding]
232721007370	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
232721007371	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
232721007372	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721007373	dimer interface [polypeptide binding]; other site
232721007374	phosphorylation site [posttranslational modification]
232721007375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721007376	ATP binding site [chemical binding]; other site
232721007377	Mg2+ binding site [ion binding]; other site
232721007378	G-X-G motif; other site
232721007379	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
232721007380	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
232721007381	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
232721007382	catalytic residues [active]
232721007383	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
232721007384	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721007385	dimerization interface [polypeptide binding]; other site
232721007386	putative DNA binding site [nucleotide binding]; other site
232721007387	putative Zn2+ binding site [ion binding]; other site
232721007388	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
232721007389	Predicted transporter component [General function prediction only]; Region: COG2391
232721007390	Sulphur transport; Region: Sulf_transp; pfam04143
232721007391	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
232721007392	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
232721007393	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
232721007394	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721007395	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
232721007396	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
232721007397	dimer interface [polypeptide binding]; other site
232721007398	active site
232721007399	Homeodomain-like domain; Region: HTH_23; pfam13384
232721007400	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721007401	Integrase core domain; Region: rve; pfam00665
232721007402	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721007403	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721007404	Walker A motif; other site
232721007405	ATP binding site [chemical binding]; other site
232721007406	Walker B motif; other site
232721007407	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
232721007408	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
232721007409	Beta protein; Region: Beta_protein; pfam14350
232721007410	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721007411	non-specific DNA binding site [nucleotide binding]; other site
232721007412	salt bridge; other site
232721007413	sequence-specific DNA binding site [nucleotide binding]; other site
232721007414	Domain of unknown function (DUF955); Region: DUF955; pfam06114
232721007415	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
232721007416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
232721007417	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
232721007418	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
232721007419	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
232721007420	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
232721007421	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
232721007422	Transposase; Region: HTH_Tnp_1; pfam01527
232721007423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
232721007424	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
232721007425	Part of AAA domain; Region: AAA_19; pfam13245
232721007426	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
232721007427	AAA domain; Region: AAA_23; pfam13476
232721007428	AAA domain; Region: AAA_21; pfam13304
232721007429	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
232721007430	putative active site [active]
232721007431	putative metal-binding site [ion binding]; other site
232721007432	integrase; Provisional; Region: PRK09692
232721007433	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
232721007434	active site
232721007435	Int/Topo IB signature motif; other site
232721007436	phosphoglycolate phosphatase; Provisional; Region: PRK13222
232721007437	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721007438	motif II; other site
232721007439	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
232721007440	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721007441	S-adenosylmethionine binding site [chemical binding]; other site
232721007442	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
232721007443	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
232721007444	ligand binding site [chemical binding]; other site
232721007445	DNA gyrase subunit A; Validated; Region: PRK05560
232721007446	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
232721007447	CAP-like domain; other site
232721007448	active site
232721007449	primary dimer interface [polypeptide binding]; other site
232721007450	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
232721007451	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
232721007452	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
232721007453	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
232721007454	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
232721007455	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
232721007456	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
232721007457	homodimer interface [polypeptide binding]; other site
232721007458	substrate-cofactor binding pocket; other site
232721007459	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721007460	catalytic residue [active]
232721007461	Chorismate mutase type II; Region: CM_2; pfam01817
232721007462	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
232721007463	Prephenate dehydratase; Region: PDT; pfam00800
232721007464	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
232721007465	putative L-Phe binding site [chemical binding]; other site
232721007466	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
232721007467	prephenate dehydrogenase; Validated; Region: PRK08507
232721007468	bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase; Provisional; Region: PRK11860
232721007469	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
232721007470	hinge; other site
232721007471	active site
232721007472	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
232721007473	CMP-binding site; other site
232721007474	The sites determining sugar specificity; other site
232721007475	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
232721007476	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
232721007477	RNA binding site [nucleotide binding]; other site
232721007478	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
232721007479	RNA binding site [nucleotide binding]; other site
232721007480	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
232721007481	RNA binding site [nucleotide binding]; other site
232721007482	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
232721007483	RNA binding site [nucleotide binding]; other site
232721007484	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
232721007485	RNA binding site [nucleotide binding]; other site
232721007486	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
232721007487	RNA binding site [nucleotide binding]; other site
232721007488	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
232721007489	IHF - DNA interface [nucleotide binding]; other site
232721007490	IHF dimer interface [polypeptide binding]; other site
232721007491	tetratricopeptide repeat protein; Provisional; Region: PRK11788
232721007492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
232721007493	binding surface
232721007494	TPR motif; other site
232721007495	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
232721007496	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
232721007497	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
232721007498	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
232721007499	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
232721007500	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
232721007501	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
232721007502	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
232721007503	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
232721007504	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
232721007505	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
232721007506	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
232721007507	5-oxoprolinase; Region: PLN02666
232721007508	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
232721007509	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
232721007510	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
232721007511	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232
232721007512	putative active site [active]
232721007513	Zn binding site [ion binding]; other site
232721007514	MarR family; Region: MarR_2; cl17246
232721007515	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
232721007516	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
232721007517	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
232721007518	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
232721007519	DctM-like transporters; Region: DctM; pfam06808
232721007520	chromosome condensation membrane protein; Provisional; Region: PRK14196
232721007521	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
232721007522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721007523	putative substrate translocation pore; other site
232721007524	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721007525	RmuC family; Region: RmuC; pfam02646
232721007526	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
232721007527	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
232721007528	dimerization interface [polypeptide binding]; other site
232721007529	ligand binding site [chemical binding]; other site
232721007530	NADP binding site [chemical binding]; other site
232721007531	catalytic site [active]
232721007532	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
232721007533	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
232721007534	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
232721007535	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
232721007536	active site
232721007537	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
232721007538	active site
232721007539	Phasin protein; Region: Phasin_2; pfam09361
232721007540	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
232721007541	Peptidase family M23; Region: Peptidase_M23; pfam01551
232721007542	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
232721007543	pseudouridine synthase; Region: TIGR00093
232721007544	active site
232721007545	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
232721007546	Sel1-like repeats; Region: SEL1; smart00671
232721007547	Predicted permeases [General function prediction only]; Region: RarD; COG2962
232721007548	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
232721007549	Staphylococcal nuclease homologues; Region: SNc; smart00318
232721007550	Catalytic site; other site
232721007551	Staphylococcal nuclease homologue; Region: SNase; pfam00565
232721007552	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
232721007553	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
232721007554	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
232721007555	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
232721007556	active site
232721007557	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
232721007558	MgtC family; Region: MgtC; pfam02308
232721007559	OsmC-like protein; Region: OsmC; pfam02566
232721007560	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
232721007561	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
232721007562	GTP/Mg2+ binding site [chemical binding]; other site
232721007563	G4 box; other site
232721007564	G5 box; other site
232721007565	G1 box; other site
232721007566	Switch I region; other site
232721007567	G2 box; other site
232721007568	G3 box; other site
232721007569	Switch II region; other site
232721007570	Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791
232721007571	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
232721007572	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
232721007573	P loop; other site
232721007574	Nucleotide binding site [chemical binding]; other site
232721007575	DTAP/Switch II; other site
232721007576	Switch I; other site
232721007577	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
232721007578	P loop; other site
232721007579	Nucleotide binding site [chemical binding]; other site
232721007580	DTAP/Switch II; other site
232721007581	Switch I; other site
232721007582	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721007583	putative DNA binding site [nucleotide binding]; other site
232721007584	putative Zn2+ binding site [ion binding]; other site
232721007585	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
232721007586	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
232721007587	putative metal binding site [ion binding]; other site
232721007588	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
232721007589	Low molecular weight phosphatase family; Region: LMWPc; cd00115
232721007590	active site
232721007591	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
232721007592	arsenical-resistance protein; Region: acr3; TIGR00832
232721007593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721007594	putative substrate translocation pore; other site
232721007595	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
232721007596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721007597	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
232721007598	substrate binding pocket [chemical binding]; other site
232721007599	dimerization interface [polypeptide binding]; other site
232721007600	thiamine pyrophosphate protein; Validated; Region: PRK08199
232721007601	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
232721007602	PYR/PP interface [polypeptide binding]; other site
232721007603	dimer interface [polypeptide binding]; other site
232721007604	TPP binding site [chemical binding]; other site
232721007605	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
232721007606	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
232721007607	TPP-binding site [chemical binding]; other site
232721007608	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
232721007609	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
232721007610	homodimer interface [polypeptide binding]; other site
232721007611	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
232721007612	NAD binding site [chemical binding]; other site
232721007613	active site
232721007614	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
232721007615	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
232721007616	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
232721007617	active site
232721007618	DNA binding site [nucleotide binding]
232721007619	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
232721007620	DNA binding site [nucleotide binding]
232721007621	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
232721007622	nucleotide binding site [chemical binding]; other site
232721007623	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
232721007624	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
232721007625	putative DNA binding site [nucleotide binding]; other site
232721007626	putative homodimer interface [polypeptide binding]; other site
232721007627	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
232721007628	Divergent AAA domain; Region: AAA_4; pfam04326
232721007629	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
232721007630	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
232721007631	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
232721007632	active site
232721007633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721007634	Walker A/P-loop; other site
232721007635	ATP binding site [chemical binding]; other site
232721007636	AAA domain; Region: AAA_21; pfam13304
232721007637	T5orf172 domain; Region: T5orf172; pfam10544
232721007638	DEAD-like helicases superfamily; Region: DEXDc; smart00487
232721007639	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721007640	ATP binding site [chemical binding]; other site
232721007641	putative Mg++ binding site [ion binding]; other site
232721007642	Methyltransferase domain; Region: Methyltransf_26; pfam13659
232721007643	Helix-turn-helix domain; Region: HTH_17; pfam12728
232721007644	Toxin of toxin-antitoxin type 1 system; Region: plasmid_Toxin; pfam12703
232721007645	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
232721007646	entry exclusion lipoprotein TrbK; Region: TrbK_RP4; TIGR04359
232721007647	conjugal transfer protein TrbJ; Provisional; Region: PRK13879
232721007648	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
232721007649	Replication protein C (RepC); Region: RepC; pfam06504
232721007650	AAA domain; Region: AAA_25; pfam13481
232721007651	Hexameric Replicative Helicase RepA.  RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125
232721007652	Walker A motif; other site
232721007653	NTP binding site [chemical binding]; other site
232721007654	hexamer interface [polypeptide binding]; other site
232721007655	Walker B motif; other site
232721007656	SPRY domain; Region: SPRY; cl02614
232721007657	putative transcriptional regulator; Provisional; Region: tfx; cl17550
232721007658	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
232721007659	integrase; Provisional; Region: PRK09692
232721007660	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
232721007661	active site
232721007662	Int/Topo IB signature motif; other site
232721007663	GMP synthase; Reviewed; Region: guaA; PRK00074
232721007664	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
232721007665	AMP/PPi binding site [chemical binding]; other site
232721007666	candidate oxyanion hole; other site
232721007667	catalytic triad [active]
232721007668	potential glutamine specificity residues [chemical binding]; other site
232721007669	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
232721007670	ATP Binding subdomain [chemical binding]; other site
232721007671	Ligand Binding sites [chemical binding]; other site
232721007672	Dimerization subdomain; other site
232721007673	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
232721007674	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
232721007675	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
232721007676	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
232721007677	active site
232721007678	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
232721007679	RnfH family Ubiquitin; Region: Ub-RnfH; cl17382
232721007680	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
232721007681	putative coenzyme Q binding site [chemical binding]; other site
232721007682	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
232721007683	SmpB-tmRNA interface; other site
232721007684	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
232721007685	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
232721007686	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
232721007687	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
232721007688	DNA binding residues [nucleotide binding]
232721007689	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
232721007690	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
232721007691	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721007692	substrate binding site [chemical binding]; other site
232721007693	oxyanion hole (OAH) forming residues; other site
232721007694	trimer interface [polypeptide binding]; other site
232721007695	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
232721007696	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
232721007697	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
232721007698	G1 box; other site
232721007699	putative GEF interaction site [polypeptide binding]; other site
232721007700	GTP/Mg2+ binding site [chemical binding]; other site
232721007701	Switch I region; other site
232721007702	G2 box; other site
232721007703	G3 box; other site
232721007704	Switch II region; other site
232721007705	G4 box; other site
232721007706	G5 box; other site
232721007707	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
232721007708	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
232721007709	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
232721007710	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
232721007711	RNA binding site [nucleotide binding]; other site
232721007712	active site
232721007713	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
232721007714	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
232721007715	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
232721007716	translation initiation factor IF-2; Region: IF-2; TIGR00487
232721007717	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
232721007718	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
232721007719	G1 box; other site
232721007720	putative GEF interaction site [polypeptide binding]; other site
232721007721	GTP/Mg2+ binding site [chemical binding]; other site
232721007722	Switch I region; other site
232721007723	G2 box; other site
232721007724	G3 box; other site
232721007725	Switch II region; other site
232721007726	G4 box; other site
232721007727	G5 box; other site
232721007728	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
232721007729	Translation-initiation factor 2; Region: IF-2; pfam11987
232721007730	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
232721007731	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
232721007732	NusA N-terminal domain; Region: NusA_N; pfam08529
232721007733	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
232721007734	RNA binding site [nucleotide binding]; other site
232721007735	homodimer interface [polypeptide binding]; other site
232721007736	NusA-like KH domain; Region: KH_5; pfam13184
232721007737	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
232721007738	G-X-X-G motif; other site
232721007739	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
232721007740	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
232721007741	ribosome maturation protein RimP; Reviewed; Region: PRK00092
232721007742	Sm and related proteins; Region: Sm_like; cl00259
232721007743	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
232721007744	putative oligomer interface [polypeptide binding]; other site
232721007745	putative RNA binding site [nucleotide binding]; other site
232721007746	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
232721007747	catalytic residues [active]
232721007748	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
232721007749	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
232721007750	Cytochrome c; Region: Cytochrom_C; pfam00034
232721007751	Cytochrome c; Region: Cytochrom_C; cl11414
232721007752	Cytochrome c; Region: Cytochrom_C; cl11414
232721007753	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
232721007754	classical (c) SDRs; Region: SDR_c; cd05233
232721007755	NAD(P) binding site [chemical binding]; other site
232721007756	active site
232721007757	ribonuclease R; Region: RNase_R; TIGR02063
232721007758	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
232721007759	RNB domain; Region: RNB; pfam00773
232721007760	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
232721007761	RNA binding site [nucleotide binding]; other site
232721007762	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
232721007763	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
232721007764	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
232721007765	RNA/DNA hybrid binding site [nucleotide binding]; other site
232721007766	active site
232721007767	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
232721007768	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
232721007769	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
232721007770	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
232721007771	active site
232721007772	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
232721007773	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
232721007774	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
232721007775	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
232721007776	trimer interface [polypeptide binding]; other site
232721007777	active site
232721007778	UDP-GlcNAc binding site [chemical binding]; other site
232721007779	lipid binding site [chemical binding]; lipid-binding site
232721007780	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
232721007781	periplasmic chaperone; Provisional; Region: PRK10780
232721007782	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
232721007783	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
232721007784	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
232721007785	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
232721007786	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
232721007787	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
232721007788	Surface antigen; Region: Bac_surface_Ag; pfam01103
232721007789	zinc metallopeptidase RseP; Provisional; Region: PRK10779
232721007790	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
232721007791	active site
232721007792	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
232721007793	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
232721007794	putative substrate binding region [chemical binding]; other site
232721007795	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
232721007796	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
232721007797	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
232721007798	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
232721007799	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
232721007800	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
232721007801	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
232721007802	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
232721007803	catalytic residue [active]
232721007804	putative FPP diphosphate  binding site; other site
232721007805	putative FPP binding hydrophobic cleft; other site
232721007806	dimer interface [polypeptide binding]; other site
232721007807	putative IPP diphosphate binding site; other site
232721007808	ribosome recycling factor; Reviewed; Region: frr; PRK00083
232721007809	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
232721007810	hinge region; other site
232721007811	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
232721007812	putative nucleotide binding site [chemical binding]; other site
232721007813	uridine monophosphate binding site [chemical binding]; other site
232721007814	homohexameric interface [polypeptide binding]; other site
232721007815	elongation factor Ts; Provisional; Region: tsf; PRK09377
232721007816	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
232721007817	Elongation factor TS; Region: EF_TS; pfam00889
232721007818	Elongation factor TS; Region: EF_TS; pfam00889
232721007819	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
232721007820	rRNA interaction site [nucleotide binding]; other site
232721007821	S8 interaction site; other site
232721007822	putative laminin-1 binding site; other site
232721007823	amidase; Provisional; Region: PRK07056
232721007824	Amidase; Region: Amidase; cl11426
232721007825	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
232721007826	hydroxyglutarate oxidase; Provisional; Region: PRK11728
232721007827	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
232721007828	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
232721007829	ATP binding site [chemical binding]; other site
232721007830	substrate binding site [chemical binding]; other site
232721007831	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
232721007832	mce related protein; Region: MCE; pfam02470
232721007833	Permease; Region: Permease; pfam02405
232721007834	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
232721007835	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
232721007836	DNA binding residues [nucleotide binding]
232721007837	dimer interface [polypeptide binding]; other site
232721007838	putative metal binding site [ion binding]; other site
232721007839	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
232721007840	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721007841	Soluble P-type ATPase [General function prediction only]; Region: COG4087
232721007842	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
232721007843	Uncharacterized conserved protein [Function unknown]; Region: COG1284
232721007844	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
232721007845	Outer membrane efflux protein; Region: OEP; pfam02321
232721007846	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
232721007847	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
232721007848	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
232721007849	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
232721007850	Predicted metal-binding protein [General function prediction only]; Region: COG3019
232721007851	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
232721007852	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
232721007853	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721007854	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721007855	motif II; other site
232721007856	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
232721007857	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
232721007858	cleavage site
232721007859	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
232721007860	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
232721007861	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
232721007862	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721007863	Walker A/P-loop; other site
232721007864	ATP binding site [chemical binding]; other site
232721007865	Q-loop/lid; other site
232721007866	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
232721007867	ABC transporter; Region: ABC_tran_2; pfam12848
232721007868	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
232721007869	helicase 45; Provisional; Region: PTZ00424
232721007870	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
232721007871	ATP binding site [chemical binding]; other site
232721007872	Mg++ binding site [ion binding]; other site
232721007873	motif III; other site
232721007874	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721007875	nucleotide binding region [chemical binding]; other site
232721007876	ATP-binding site [chemical binding]; other site
232721007877	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
232721007878	active site
232721007879	Zn binding site [ion binding]; other site
232721007880	Integrase core domain; Region: rve; pfam00665
232721007881	Integrase core domain; Region: rve_3; pfam13683
232721007882	Homeodomain-like domain; Region: HTH_23; pfam13384
232721007883	Winged helix-turn helix; Region: HTH_29; pfam13551
232721007884	Homeodomain-like domain; Region: HTH_32; pfam13565
232721007885	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721007886	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721007887	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721007888	putative DNA binding site [nucleotide binding]; other site
232721007889	dimerization interface [polypeptide binding]; other site
232721007890	putative Zn2+ binding site [ion binding]; other site
232721007891	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
232721007892	HsdM N-terminal domain; Region: HsdM_N; pfam12161
232721007893	Methyltransferase domain; Region: Methyltransf_26; pfam13659
232721007894	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
232721007895	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
232721007896	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721007897	ATP binding site [chemical binding]; other site
232721007898	putative Mg++ binding site [ion binding]; other site
232721007899	SurA N-terminal domain; Region: SurA_N_3; cl07813
232721007900	periplasmic folding chaperone; Provisional; Region: PRK10788
232721007901	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
232721007902	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
232721007903	IHF dimer interface [polypeptide binding]; other site
232721007904	IHF - DNA interface [nucleotide binding]; other site
232721007905	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
232721007906	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
232721007907	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
232721007908	GIY-YIG motif/motif A; other site
232721007909	active site
232721007910	catalytic site [active]
232721007911	putative DNA binding site [nucleotide binding]; other site
232721007912	metal binding site [ion binding]; metal-binding site
232721007913	UvrB/uvrC motif; Region: UVR; pfam02151
232721007914	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
232721007915	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
232721007916	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
232721007917	active site
232721007918	Int/Topo IB signature motif; other site
232721007919	DNA binding site [nucleotide binding]
232721007920	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
232721007921	Predicted transcriptional regulator [Transcription]; Region: COG2944
232721007922	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721007923	non-specific DNA binding site [nucleotide binding]; other site
232721007924	salt bridge; other site
232721007925	sequence-specific DNA binding site [nucleotide binding]; other site
232721007926	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
232721007927	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
232721007928	putative metal binding site [ion binding]; other site
232721007929	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
232721007930	putative uracil binding site [chemical binding]; other site
232721007931	putative active site [active]
232721007932	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
232721007933	TIR domain; Region: TIR_2; pfam13676
232721007934	hypothetical protein; Reviewed; Region: PRK00024
232721007935	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
232721007936	MPN+ (JAMM) motif; other site
232721007937	Zinc-binding site [ion binding]; other site
232721007938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694
232721007939	Domain of unknown function (DUF932); Region: DUF932; pfam06067
232721007940	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
232721007941	ParB-like nuclease domain; Region: ParBc; pfam02195
232721007942	Uncharacterized conserved protein [Function unknown]; Region: COG5489
232721007943	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721007944	non-specific DNA binding site [nucleotide binding]; other site
232721007945	salt bridge; other site
232721007946	sequence-specific DNA binding site [nucleotide binding]; other site
232721007947	TniQ; Region: TniQ; pfam06527
232721007948	Helix-turn-helix domain; Region: HTH_28; pfam13518
232721007949	Winged helix-turn helix; Region: HTH_29; pfam13551
232721007950	Bacterial TniB protein; Region: TniB; pfam05621
232721007951	AAA domain; Region: AAA_22; pfam13401
232721007952	Integrase core domain; Region: rve; pfam00665
232721007953	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
232721007954	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
232721007955	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
232721007956	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
232721007957	Helix-turn-helix domain; Region: HTH_17; cl17695
232721007958	Replication initiator protein A; Region: RPA; pfam10134
232721007959	ParA-like protein; Provisional; Region: PHA02518
232721007960	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721007961	P-loop; other site
232721007962	Magnesium ion binding site [ion binding]; other site
232721007963	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
232721007964	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
232721007965	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
232721007966	Winged helix-turn helix; Region: HTH_29; pfam13551
232721007967	Integrase core domain; Region: rve; pfam00665
232721007968	Integrase core domain; Region: rve_3; pfam13683
232721007969	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
232721007970	Transposase, Mutator family; Region: Transposase_mut; pfam00872
232721007971	MULE transposase domain; Region: MULE; pfam10551
232721007972	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
232721007973	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
232721007974	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
232721007975	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
232721007976	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
232721007977	Outer membrane efflux protein; Region: OEP; pfam02321
232721007978	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365
232721007979	Outer membrane efflux protein; Region: OEP; pfam02321
232721007980	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
232721007981	Acetokinase family; Region: Acetate_kinase; cl17229
232721007982	propionate/acetate kinase; Provisional; Region: PRK12379
232721007983	Helix-Turn-Helix DNA binding domain of putative Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR_unk; cd04787
232721007984	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
232721007985	DNA binding residues [nucleotide binding]
232721007986	dimer interface [polypeptide binding]; other site
232721007987	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
232721007988	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721007989	S-adenosylmethionine binding site [chemical binding]; other site
232721007990	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
232721007991	XFP N-terminal domain; Region: XFP_N; pfam09364
232721007992	glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207
232721007993	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
232721007994	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
232721007995	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
232721007996	ABC1 family; Region: ABC1; cl17513
232721007997	D-Lactate and related Dehydrogenase like proteins, NAD-binding and catalytic domains; Region: LDH_like_1; cd12187
232721007998	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
232721007999	ligand binding site [chemical binding]; other site
232721008000	NAD binding site [chemical binding]; other site
232721008001	homodimer interface [polypeptide binding]; other site
232721008002	catalytic site [active]
232721008003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721008004	Transposase domain (DUF772); Region: DUF772; pfam05598
232721008005	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721008006	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721008007	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
232721008008	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
232721008009	protein binding site [polypeptide binding]; other site
232721008010	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
232721008011	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
232721008012	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
232721008013	active site
232721008014	thymidine phosphorylase; Provisional; Region: PRK04350
232721008015	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
232721008016	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
232721008017	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
232721008018	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
232721008019	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
232721008020	Beta-Casp domain; Region: Beta-Casp; smart01027
232721008021	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
232721008022	Repair protein; Region: Repair_PSII; pfam04536
232721008023	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
232721008024	Repair protein; Region: Repair_PSII; pfam04536
232721008025	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
232721008026	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
232721008027	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
232721008028	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721008029	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721008030	motif II; other site
232721008031	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
232721008032	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
232721008033	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
232721008034	DNA binding residues [nucleotide binding]
232721008035	dimer interface [polypeptide binding]; other site
232721008036	mercury binding site [ion binding]; other site
232721008037	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
232721008038	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
232721008039	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
232721008040	Trehalase; Region: Trehalase; cl17346
232721008041	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721008042	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
232721008043	Outer membrane efflux protein; Region: OEP; pfam02321
232721008044	Outer membrane efflux protein; Region: OEP; pfam02321
232721008045	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
232721008046	Predicted membrane protein [Function unknown]; Region: COG3174
232721008047	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
232721008048	Transposase domain (DUF772); Region: DUF772; pfam05598
232721008049	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
232721008050	YHS domain; Region: YHS; pfam04945
232721008051	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
232721008052	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
232721008053	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721008054	motif II; other site
232721008055	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
232721008056	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
232721008057	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
232721008058	Copper resistance protein K; Region: CopK; pfam11525
232721008059	Transposase domain (DUF772); Region: DUF772; pfam05598
232721008060	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721008061	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721008062	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721008063	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
232721008064	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
232721008065	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
232721008066	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
232721008067	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
232721008068	Outer membrane efflux protein; Region: OEP; pfam02321
232721008069	Outer membrane efflux protein; Region: OEP; pfam02321
232721008070	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
232721008071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721008072	active site
232721008073	phosphorylation site [posttranslational modification]
232721008074	intermolecular recognition site; other site
232721008075	dimerization interface [polypeptide binding]; other site
232721008076	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721008077	DNA binding site [nucleotide binding]
232721008078	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
232721008079	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721008080	dimerization interface [polypeptide binding]; other site
232721008081	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721008082	dimer interface [polypeptide binding]; other site
232721008083	phosphorylation site [posttranslational modification]
232721008084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721008085	ATP binding site [chemical binding]; other site
232721008086	Mg2+ binding site [ion binding]; other site
232721008087	G-X-G motif; other site
232721008088	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
232721008089	Winged helix-turn helix; Region: HTH_29; pfam13551
232721008090	Homeodomain-like domain; Region: HTH_32; pfam13565
232721008091	Winged helix-turn helix; Region: HTH_33; pfam13592
232721008092	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721008093	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721008094	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
232721008095	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
232721008096	active site
232721008097	HIGH motif; other site
232721008098	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
232721008099	active site
232721008100	KMSKS motif; other site
232721008101	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
232721008102	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
232721008103	homodimer interface [polypeptide binding]; other site
232721008104	substrate-cofactor binding pocket; other site
232721008105	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721008106	catalytic residue [active]
232721008107	amidophosphoribosyltransferase; Provisional; Region: PRK09246
232721008108	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
232721008109	active site
232721008110	tetramer interface [polypeptide binding]; other site
232721008111	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
232721008112	active site
232721008113	Colicin V production protein; Region: Colicin_V; pfam02674
232721008114	Sporulation related domain; Region: SPOR; pfam05036
232721008115	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
232721008116	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
232721008117	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
232721008118	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
232721008119	ArsC family; Region: ArsC; pfam03960
232721008120	putative catalytic residues [active]
232721008121	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
232721008122	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
232721008123	argininosuccinate synthase; Validated; Region: PRK05370
232721008124	argininosuccinate synthase; Provisional; Region: PRK13820
232721008125	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
232721008126	Ligand Binding Site [chemical binding]; other site
232721008127	hypothetical protein; Provisional; Region: PRK11212
232721008128	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
232721008129	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
232721008130	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
232721008131	DNA binding residues [nucleotide binding]
232721008132	SnoaL-like domain; Region: SnoaL_2; pfam12680
232721008133	Uncharacterized conserved protein [Function unknown]; Region: COG2128
232721008134	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
232721008135	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
232721008136	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
232721008137	transmembrane helices; other site
232721008138	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
232721008139	FAD binding domain; Region: FAD_binding_4; pfam01565
232721008140	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
232721008141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
232721008142	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
232721008143	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
232721008144	catalytic motif [active]
232721008145	Catalytic residue [active]
232721008146	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
232721008147	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
232721008148	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
232721008149	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
232721008150	putative deacylase active site [active]
232721008151	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
232721008152	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
232721008153	active site
232721008154	catalytic tetrad [active]
232721008155	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
232721008156	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
232721008157	PGAP1-like protein; Region: PGAP1; pfam07819
232721008158	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
232721008159	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742
232721008160	peptide chain release factor 2; Validated; Region: prfB; PRK00578
232721008161	This domain is found in peptide chain release factors; Region: PCRF; smart00937
232721008162	RF-1 domain; Region: RF-1; pfam00472
232721008163	aminopeptidase N; Provisional; Region: pepN; PRK14015
232721008164	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
232721008165	active site
232721008166	Zn binding site [ion binding]; other site
232721008167	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
232721008168	AMP binding site [chemical binding]; other site
232721008169	metal binding site [ion binding]; metal-binding site
232721008170	active site
232721008171	DNA ligase; Provisional; Region: PRK09125
232721008172	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
232721008173	DNA binding site [nucleotide binding]
232721008174	active site
232721008175	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
232721008176	DNA binding site [nucleotide binding]
232721008177	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
232721008178	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
232721008179	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
232721008180	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721008181	catalytic residue [active]
232721008182	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
232721008183	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
232721008184	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
232721008185	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
232721008186	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
232721008187	catalytic loop [active]
232721008188	iron binding site [ion binding]; other site
232721008189	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
232721008190	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
232721008191	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
232721008192	dimerization interface [polypeptide binding]; other site
232721008193	active site
232721008194	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
232721008195	homopentamer interface [polypeptide binding]; other site
232721008196	active site
232721008197	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
232721008198	putative RNA binding site [nucleotide binding]; other site
232721008199	aminotransferase; Validated; Region: PRK07337
232721008200	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721008201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721008202	homodimer interface [polypeptide binding]; other site
232721008203	catalytic residue [active]
232721008204	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
232721008205	active site
232721008206	TolQ protein; Region: tolQ; TIGR02796
232721008207	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
232721008208	TolR protein; Region: tolR; TIGR02801
232721008209	TolA protein; Region: tolA_full; TIGR02794
232721008210	TonB C terminal; Region: TonB_2; pfam13103
232721008211	metabolite-proton symporter; Region: 2A0106; TIGR00883
232721008212	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
232721008213	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
232721008214	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
232721008215	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
232721008216	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
232721008217	D-pathway; other site
232721008218	Putative ubiquinol binding site [chemical binding]; other site
232721008219	Low-spin heme (heme b) binding site [chemical binding]; other site
232721008220	Putative water exit pathway; other site
232721008221	Binuclear center (heme o3/CuB) [ion binding]; other site
232721008222	K-pathway; other site
232721008223	Putative proton exit pathway; other site
232721008224	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
232721008225	Subunit I/III interface [polypeptide binding]; other site
232721008226	Subunit III/IV interface [polypeptide binding]; other site
232721008227	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
232721008228	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
232721008229	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
232721008230	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721008231	dimer interface [polypeptide binding]; other site
232721008232	phosphorylation site [posttranslational modification]
232721008233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721008234	ATP binding site [chemical binding]; other site
232721008235	Mg2+ binding site [ion binding]; other site
232721008236	G-X-G motif; other site
232721008237	Response regulator receiver domain; Region: Response_reg; pfam00072
232721008238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721008239	active site
232721008240	phosphorylation site [posttranslational modification]
232721008241	intermolecular recognition site; other site
232721008242	dimerization interface [polypeptide binding]; other site
232721008243	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
232721008244	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
232721008245	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
232721008246	C-terminal domain interface [polypeptide binding]; other site
232721008247	GSH binding site (G-site) [chemical binding]; other site
232721008248	dimer interface [polypeptide binding]; other site
232721008249	putative protease; Provisional; Region: PRK15452
232721008250	Peptidase family U32; Region: Peptidase_U32; pfam01136
232721008251	Basic region leucine zipper; Region: bZIP_2; pfam07716
232721008252	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
232721008253	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721008254	non-specific DNA binding site [nucleotide binding]; other site
232721008255	salt bridge; other site
232721008256	sequence-specific DNA binding site [nucleotide binding]; other site
232721008257	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
232721008258	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
232721008259	substrate binding site [chemical binding]; other site
232721008260	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
232721008261	substrate binding site [chemical binding]; other site
232721008262	ligand binding site [chemical binding]; other site
232721008263	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
232721008264	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
232721008265	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721008266	S-adenosylmethionine binding site [chemical binding]; other site
232721008267	malate dehydrogenase; Provisional; Region: PRK05442
232721008268	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
232721008269	NAD(P) binding site [chemical binding]; other site
232721008270	dimer interface [polypeptide binding]; other site
232721008271	malate binding site [chemical binding]; other site
232721008272	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
232721008273	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
232721008274	DNA-binding site [nucleotide binding]; DNA binding site
232721008275	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
232721008276	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
232721008277	Iron-sulfur protein interface; other site
232721008278	proximal quinone binding site [chemical binding]; other site
232721008279	SdhD (CybS) interface [polypeptide binding]; other site
232721008280	proximal heme binding site [chemical binding]; other site
232721008281	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
232721008282	SdhC subunit interface [polypeptide binding]; other site
232721008283	proximal heme binding site [chemical binding]; other site
232721008284	cardiolipin binding site; other site
232721008285	Iron-sulfur protein interface; other site
232721008286	proximal quinone binding site [chemical binding]; other site
232721008287	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
232721008288	L-aspartate oxidase; Provisional; Region: PRK06175
232721008289	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
232721008290	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
232721008291	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
232721008292	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
232721008293	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
232721008294	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
232721008295	dimer interface [polypeptide binding]; other site
232721008296	active site
232721008297	citrylCoA binding site [chemical binding]; other site
232721008298	NADH binding [chemical binding]; other site
232721008299	cationic pore residues; other site
232721008300	oxalacetate/citrate binding site [chemical binding]; other site
232721008301	coenzyme A binding site [chemical binding]; other site
232721008302	catalytic triad [active]
232721008303	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
232721008304	putative metal binding site [ion binding]; other site
232721008305	putative homodimer interface [polypeptide binding]; other site
232721008306	putative homotetramer interface [polypeptide binding]; other site
232721008307	putative homodimer-homodimer interface [polypeptide binding]; other site
232721008308	putative allosteric switch controlling residues; other site
232721008309	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
232721008310	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
232721008311	substrate binding site [chemical binding]; other site
232721008312	catalytic Zn binding site [ion binding]; other site
232721008313	NAD binding site [chemical binding]; other site
232721008314	structural Zn binding site [ion binding]; other site
232721008315	dimer interface [polypeptide binding]; other site
232721008316	S-formylglutathione hydrolase; Region: PLN02442
232721008317	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
232721008318	Uncharacterized conserved protein [Function unknown]; Region: COG1359
232721008319	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
232721008320	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
232721008321	FeS/SAM binding site; other site
232721008322	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
232721008323	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
232721008324	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
232721008325	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
232721008326	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
232721008327	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
232721008328	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
232721008329	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
232721008330	FMN binding site [chemical binding]; other site
232721008331	substrate binding site [chemical binding]; other site
232721008332	putative catalytic residue [active]
232721008333	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
232721008334	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
232721008335	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721008336	active site
232721008337	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
232721008338	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
232721008339	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
232721008340	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
232721008341	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
232721008342	Ligand binding site [chemical binding]; other site
232721008343	Electron transfer flavoprotein domain; Region: ETF; pfam01012
232721008344	Mechanosensitive ion channel; Region: MS_channel; pfam00924
232721008345	enoyl-CoA hydratase; Validated; Region: PRK08139
232721008346	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721008347	substrate binding site [chemical binding]; other site
232721008348	oxyanion hole (OAH) forming residues; other site
232721008349	trimer interface [polypeptide binding]; other site
232721008350	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
232721008351	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
232721008352	putative active site [active]
232721008353	Zn binding site [ion binding]; other site
232721008354	MoxR-like ATPases [General function prediction only]; Region: COG0714
232721008355	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721008356	Walker A motif; other site
232721008357	ATP binding site [chemical binding]; other site
232721008358	Walker B motif; other site
232721008359	arginine finger; other site
232721008360	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
232721008361	Pleckstrin homology-like domain; Region: PH-like; cl17171
232721008362	Protein of unknown function DUF58; Region: DUF58; pfam01882
232721008363	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
232721008364	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
232721008365	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
232721008366	Transglycosylase SLT domain; Region: SLT_2; pfam13406
232721008367	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
232721008368	N-acetyl-D-glucosamine binding site [chemical binding]; other site
232721008369	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
232721008370	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721008371	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
232721008372	putative dimerization interface [polypeptide binding]; other site
232721008373	Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601
232721008374	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
232721008375	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
232721008376	putative ligand binding site [chemical binding]; other site
232721008377	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
232721008378	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
232721008379	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
232721008380	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
232721008381	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
232721008382	FtsX-like permease family; Region: FtsX; pfam02687
232721008383	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
232721008384	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
232721008385	Walker A/P-loop; other site
232721008386	ATP binding site [chemical binding]; other site
232721008387	Q-loop/lid; other site
232721008388	ABC transporter signature motif; other site
232721008389	Walker B; other site
232721008390	D-loop; other site
232721008391	H-loop/switch region; other site
232721008392	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
232721008393	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721008394	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
232721008395	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
232721008396	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
232721008397	NAD(P) binding site [chemical binding]; other site
232721008398	catalytic residues [active]
232721008399	UGMP family protein; Validated; Region: PRK09604
232721008400	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
232721008401	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
232721008402	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
232721008403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
232721008404	active site
232721008405	phosphorylation site [posttranslational modification]
232721008406	intermolecular recognition site; other site
232721008407	dimerization interface [polypeptide binding]; other site
232721008408	ANTAR domain; Region: ANTAR; pfam03861
232721008409	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
232721008410	NMT1-like family; Region: NMT1_2; pfam13379
232721008411	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
232721008412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721008413	dimer interface [polypeptide binding]; other site
232721008414	conserved gate region; other site
232721008415	putative PBP binding loops; other site
232721008416	ABC-ATPase subunit interface; other site
232721008417	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
232721008418	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
232721008419	Walker A/P-loop; other site
232721008420	ATP binding site [chemical binding]; other site
232721008421	Q-loop/lid; other site
232721008422	ABC transporter signature motif; other site
232721008423	Walker B; other site
232721008424	D-loop; other site
232721008425	H-loop/switch region; other site
232721008426	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
232721008427	FOG: CBS domain [General function prediction only]; Region: COG0517
232721008428	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
232721008429	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
232721008430	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
232721008431	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721008432	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
232721008433	Protein export membrane protein; Region: SecD_SecF; cl14618
232721008434	Outer membrane efflux protein; Region: OEP; pfam02321
232721008435	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
232721008436	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721008437	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
232721008438	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
232721008439	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
232721008440	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
232721008441	[2Fe-2S] cluster binding site [ion binding]; other site
232721008442	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
232721008443	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
232721008444	[4Fe-4S] binding site [ion binding]; other site
232721008445	molybdopterin cofactor binding site; other site
232721008446	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
232721008447	molybdopterin cofactor binding site; other site
232721008448	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
232721008449	glycosyl transferase family protein; Provisional; Region: PRK08136
232721008450	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
232721008451	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
232721008452	active site
232721008453	SAM binding site [chemical binding]; other site
232721008454	homodimer interface [polypeptide binding]; other site
232721008455	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
232721008456	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
232721008457	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
232721008458	putative ligand binding site [chemical binding]; other site
232721008459	HI0933-like protein; Region: HI0933_like; pfam03486
232721008460	NnrS protein; Region: NnrS; pfam05940
232721008461	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
232721008462	Domain of unknown function DUF59; Region: DUF59; cl00941
232721008463	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
232721008464	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
232721008465	trimerization site [polypeptide binding]; other site
232721008466	active site
232721008467	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
232721008468	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
232721008469	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721008470	catalytic residue [active]
232721008471	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
232721008472	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
232721008473	FeS assembly ATPase SufC; Region: sufC; TIGR01978
232721008474	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721008475	Walker A/P-loop; other site
232721008476	ATP binding site [chemical binding]; other site
232721008477	Q-loop/lid; other site
232721008478	ABC transporter signature motif; other site
232721008479	Walker B; other site
232721008480	D-loop; other site
232721008481	H-loop/switch region; other site
232721008482	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
232721008483	putative ABC transporter; Region: ycf24; CHL00085
232721008484	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721008485	dimerization interface [polypeptide binding]; other site
232721008486	putative DNA binding site [nucleotide binding]; other site
232721008487	putative Zn2+ binding site [ion binding]; other site
232721008488	NIPSNAP; Region: NIPSNAP; pfam07978
232721008489	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
232721008490	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
232721008491	Yqey-like protein; Region: YqeY; pfam09424
232721008492	tartrate dehydrogenase; Region: TTC; TIGR02089
232721008493	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
232721008494	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
232721008495	putative metal binding site [ion binding]; other site
232721008496	putative homodimer interface [polypeptide binding]; other site
232721008497	putative homotetramer interface [polypeptide binding]; other site
232721008498	putative homodimer-homodimer interface [polypeptide binding]; other site
232721008499	putative allosteric switch controlling residues; other site
232721008500	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
232721008501	Protein of unknown function (DUF938); Region: DUF938; pfam06080
232721008502	Uncharacterized conserved protein [Function unknown]; Region: COG3791
232721008503	Homeodomain-like domain; Region: HTH_23; pfam13384
232721008504	Winged helix-turn helix; Region: HTH_29; pfam13551
232721008505	Homeodomain-like domain; Region: HTH_32; pfam13565
232721008506	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721008507	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721008508	Transposase domain (DUF772); Region: DUF772; pfam05598
232721008509	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721008510	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721008511	glutamate racemase; Provisional; Region: PRK00865
232721008512	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
232721008513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
232721008514	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721008515	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
232721008516	active site
232721008517	catalytic residues [active]
232721008518	metal binding site [ion binding]; metal-binding site
232721008519	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
232721008520	CoA-transferase family III; Region: CoA_transf_3; pfam02515
232721008521	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721008522	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721008523	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
232721008524	putative dimerization interface [polypeptide binding]; other site
232721008525	conserved hypothetical protein, PP_1857 family; Region: efp_adjacent_2; TIGR03837
232721008526	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
232721008527	elongation factor P; Validated; Region: PRK00529
232721008528	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
232721008529	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
232721008530	RNA binding site [nucleotide binding]; other site
232721008531	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
232721008532	RNA binding site [nucleotide binding]; other site
232721008533	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
232721008534	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
232721008535	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
232721008536	phosphoenolpyruvate synthase; Validated; Region: PRK06464
232721008537	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
232721008538	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
232721008539	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
232721008540	PEP synthetase regulatory protein; Provisional; Region: PRK05339
232721008541	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
232721008542	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
232721008543	catalytic residue [active]
232721008544	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
232721008545	catalytic residues [active]
232721008546	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
232721008547	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721008548	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
232721008549	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
232721008550	dimer interface [polypeptide binding]; other site
232721008551	decamer (pentamer of dimers) interface [polypeptide binding]; other site
232721008552	catalytic triad [active]
232721008553	peroxidatic and resolving cysteines [active]
232721008554	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
232721008555	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
232721008556	heme binding site [chemical binding]; other site
232721008557	ferroxidase pore; other site
232721008558	ferroxidase diiron center [ion binding]; other site
232721008559	Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247
232721008560	transcriptional activator FlhC; Provisional; Region: PRK12722
232721008561	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
232721008562	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
232721008563	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
232721008564	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
232721008565	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
232721008566	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
232721008567	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
232721008568	domain interfaces; other site
232721008569	active site
232721008570	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
232721008571	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
232721008572	active site
232721008573	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
232721008574	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
232721008575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721008576	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721008577	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721008578	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
232721008579	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
232721008580	Zn binding site [ion binding]; other site
232721008581	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
232721008582	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
232721008583	HIGH motif; other site
232721008584	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
232721008585	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
232721008586	active site
232721008587	KMSKS motif; other site
232721008588	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
232721008589	tRNA binding surface [nucleotide binding]; other site
232721008590	anticodon binding site; other site
232721008591	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
232721008592	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
232721008593	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
232721008594	active site
232721008595	tetramer interface; other site
232721008596	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
232721008597	CPxP  motif; other site
232721008598	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
232721008599	nudix motif; other site
232721008600	cysteine synthase B; Region: cysM; TIGR01138
232721008601	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
232721008602	dimer interface [polypeptide binding]; other site
232721008603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721008604	catalytic residue [active]
232721008605	Uncharacterized conserved small protein [Function unknown]; Region: COG5639
232721008606	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
232721008607	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
232721008608	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
232721008609	VirB7 interaction site; other site
232721008610	conjugal transfer protein TrbF; Provisional; Region: PRK13872
232721008611	conjugal transfer protein TrbL; Provisional; Region: PRK13875
232721008612	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
232721008613	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
232721008614	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
232721008615	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
232721008616	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
232721008617	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
232721008618	Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268
232721008619	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
232721008620	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
232721008621	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
232721008622	ATP binding site [chemical binding]; other site
232721008623	Walker A motif; other site
232721008624	hexamer interface [polypeptide binding]; other site
232721008625	Walker B motif; other site
232721008626	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
232721008627	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
232721008628	Walker A motif; other site
232721008629	ATP binding site [chemical binding]; other site
232721008630	Walker B motif; other site
232721008631	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
232721008632	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
232721008633	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
232721008634	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
232721008635	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
232721008636	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
232721008637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
232721008638	Transposase; Region: HTH_Tnp_1; pfam01527
232721008639	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
232721008640	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
232721008641	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721008642	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
232721008643	dimerization interface [polypeptide binding]; other site
232721008644	substrate binding pocket [chemical binding]; other site
232721008645	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
232721008646	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
232721008647	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
232721008648	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721008649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721008650	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721008651	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721008652	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
232721008653	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721008654	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
232721008655	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
232721008656	MarR family; Region: MarR_2; cl17246
232721008657	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
232721008658	Transposase domain (DUF772); Region: DUF772; pfam05598
232721008659	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721008660	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721008661	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
232721008662	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
232721008663	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
232721008664	ParA-like protein; Provisional; Region: PHA02518
232721008665	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721008666	P-loop; other site
232721008667	Magnesium ion binding site [ion binding]; other site
232721008668	Replication initiator protein A; Region: RPA; pfam10134
232721008669	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
232721008670	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
232721008671	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
232721008672	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721008673	non-specific DNA binding site [nucleotide binding]; other site
232721008674	salt bridge; other site
232721008675	sequence-specific DNA binding site [nucleotide binding]; other site
232721008676	Uncharacterized conserved protein [Function unknown]; Region: COG5489
232721008677	ParB-like nuclease domain; Region: ParBc; pfam02195
232721008678	Domain of unknown function (DUF932); Region: DUF932; pfam06067
232721008679	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
232721008680	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721008681	P-loop; other site
232721008682	Magnesium ion binding site [ion binding]; other site
232721008683	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721008684	Magnesium ion binding site [ion binding]; other site
232721008685	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
232721008686	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
232721008687	Active Sites [active]
232721008688	putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183
232721008689	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
232721008690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721008691	Walker A/P-loop; other site
232721008692	ATP binding site [chemical binding]; other site
232721008693	AAA-like domain; Region: AAA_10; pfam12846
232721008694	Domain of unknown function DUF87; Region: DUF87; pfam01935
232721008695	Transposase domain (DUF772); Region: DUF772; pfam05598
232721008696	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721008697	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721008698	DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172
232721008699	DGQHR domain; Region: DGQHR; TIGR03187
232721008700	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
232721008701	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
232721008702	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
232721008703	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
232721008704	active site
232721008705	DNA binding site [nucleotide binding]
232721008706	Int/Topo IB signature motif; other site
232721008707	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
232721008708	rRNA binding site [nucleotide binding]; other site
232721008709	predicted 30S ribosome binding site; other site
232721008710	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
232721008711	SnoaL-like domain; Region: SnoaL_2; pfam12680
232721008712	short chain dehydrogenase; Provisional; Region: PRK06101
232721008713	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721008714	NAD(P) binding site [chemical binding]; other site
232721008715	active site
232721008716	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
232721008717	MFS/sugar transport protein; Region: MFS_2; pfam13347
232721008718	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721008719	dimer interface [polypeptide binding]; other site
232721008720	putative CheW interface [polypeptide binding]; other site
232721008721	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
232721008722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
232721008723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721008724	S-adenosylmethionine binding site [chemical binding]; other site
232721008725	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
232721008726	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
232721008727	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
232721008728	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
232721008729	DNA binding residues [nucleotide binding]
232721008730	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
232721008731	B12 binding domain; Region: B12-binding_2; pfam02607
232721008732	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
232721008733	B12 binding site [chemical binding]; other site
232721008734	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
232721008735	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
232721008736	LrgA family; Region: LrgA; pfam03788
232721008737	LrgB-like family; Region: LrgB; pfam04172
232721008738	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
232721008739	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721008740	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721008741	dimerization interface [polypeptide binding]; other site
232721008742	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
232721008743	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721008744	FAD binding site [chemical binding]; other site
232721008745	substrate binding pocket [chemical binding]; other site
232721008746	catalytic base [active]
232721008747	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
232721008748	CoA-transferase family III; Region: CoA_transf_3; pfam02515
232721008749	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721008750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721008751	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721008752	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721008753	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
232721008754	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
232721008755	putative NAD(P) binding site [chemical binding]; other site
232721008756	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
232721008757	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
232721008758	catalytic loop [active]
232721008759	iron binding site [ion binding]; other site
232721008760	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
232721008761	FAD binding pocket [chemical binding]; other site
232721008762	FAD binding motif [chemical binding]; other site
232721008763	phosphate binding motif [ion binding]; other site
232721008764	beta-alpha-beta structure motif; other site
232721008765	NAD binding pocket [chemical binding]; other site
232721008766	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
232721008767	dimerization interface [polypeptide binding]; other site
232721008768	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721008769	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
232721008770	catalytic center binding site [active]
232721008771	ATP binding site [chemical binding]; other site
232721008772	poly(A) polymerase; Region: pcnB; TIGR01942
232721008773	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
232721008774	active site
232721008775	NTP binding site [chemical binding]; other site
232721008776	metal binding triad [ion binding]; metal-binding site
232721008777	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
232721008778	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
232721008779	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
232721008780	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
232721008781	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
232721008782	DnaA regulatory inactivator Hda; Region: DnaA_homol_Hda; TIGR03420
232721008783	Walker A motif; other site
232721008784	ATP binding site [chemical binding]; other site
232721008785	Walker B motif; other site
232721008786	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
232721008787	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
232721008788	dimerization interface [polypeptide binding]; other site
232721008789	putative ATP binding site [chemical binding]; other site
232721008790	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
232721008791	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
232721008792	Ligand Binding Site [chemical binding]; other site
232721008793	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
232721008794	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
232721008795	Uncharacterized conserved protein [Function unknown]; Region: COG2912
232721008796	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
232721008797	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
232721008798	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
232721008799	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
232721008800	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
232721008801	acetylornithine aminotransferase; Provisional; Region: PRK02627
232721008802	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
232721008803	inhibitor-cofactor binding pocket; inhibition site
232721008804	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721008805	catalytic residue [active]
232721008806	ornithine carbamoyltransferase; Provisional; Region: PRK00779
232721008807	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
232721008808	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
232721008809	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
232721008810	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
232721008811	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
232721008812	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
232721008813	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
232721008814	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
232721008815	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
232721008816	Chain length determinant protein; Region: Wzz; pfam02706
232721008817	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
232721008818	Chain length determinant protein; Region: Wzz; cl15801
232721008819	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
232721008820	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
232721008821	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
232721008822	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
232721008823	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
232721008824	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
232721008825	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
232721008826	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
232721008827	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
232721008828	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
232721008829	putative trimer interface [polypeptide binding]; other site
232721008830	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
232721008831	putative CoA binding site [chemical binding]; other site
232721008832	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
232721008833	putative trimer interface [polypeptide binding]; other site
232721008834	putative active site [active]
232721008835	putative substrate binding site [chemical binding]; other site
232721008836	putative CoA binding site [chemical binding]; other site
232721008837	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
232721008838	putative active site [active]
232721008839	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
232721008840	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
232721008841	inhibitor-cofactor binding pocket; inhibition site
232721008842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721008843	catalytic residue [active]
232721008844	Divergent AAA domain; Region: AAA_4; pfam04326
232721008845	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
232721008846	putative active site [active]
232721008847	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
232721008848	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
232721008849	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
232721008850	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721008851	O-Antigen ligase; Region: Wzy_C; cl04850
232721008852	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721008853	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
232721008854	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
232721008855	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
232721008856	NAD(P) binding site [chemical binding]; other site
232721008857	homodimer interface [polypeptide binding]; other site
232721008858	substrate binding site [chemical binding]; other site
232721008859	active site
232721008860	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
232721008861	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
232721008862	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
232721008863	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
232721008864	putative NAD(P) binding site [chemical binding]; other site
232721008865	active site
232721008866	putative substrate binding site [chemical binding]; other site
232721008867	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
232721008868	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721008869	AAA domain; Region: AAA_23; pfam13476
232721008870	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721008871	Walker A/P-loop; other site
232721008872	Walker A/P-loop; other site
232721008873	ATP binding site [chemical binding]; other site
232721008874	ATP binding site [chemical binding]; other site
232721008875	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
232721008876	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
232721008877	active site
232721008878	homodimer interface [polypeptide binding]; other site
232721008879	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721008880	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
232721008881	Bacterial sugar transferase; Region: Bac_transf; pfam02397
232721008882	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
232721008883	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
232721008884	putative trimer interface [polypeptide binding]; other site
232721008885	putative CoA binding site [chemical binding]; other site
232721008886	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
232721008887	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
232721008888	inhibitor-cofactor binding pocket; inhibition site
232721008889	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721008890	catalytic residue [active]
232721008891	O-Antigen ligase; Region: Wzy_C; pfam04932
232721008892	Uncharacterized conserved protein [Function unknown]; Region: COG1739
232721008893	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
232721008894	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
232721008895	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
232721008896	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
232721008897	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
232721008898	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
232721008899	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721008900	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
232721008901	DNA binding residues [nucleotide binding]
232721008902	dimerization interface [polypeptide binding]; other site
232721008903	T5orf172 domain; Region: T5orf172; pfam10544
232721008904	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
232721008905	Helix-turn-helix domain; Region: HTH_28; pfam13518
232721008906	putative transposase OrfB; Reviewed; Region: PHA02517
232721008907	HTH-like domain; Region: HTH_21; pfam13276
232721008908	Integrase core domain; Region: rve; pfam00665
232721008909	Integrase core domain; Region: rve_2; pfam13333
232721008910	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721008911	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721008912	Walker A motif; other site
232721008913	ATP binding site [chemical binding]; other site
232721008914	Walker B motif; other site
232721008915	arginine finger; other site
232721008916	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
232721008917	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721008918	Integrase core domain; Region: rve; pfam00665
232721008919	Low molecular weight phosphatase family; Region: LMWPc; cd00115
232721008920	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
232721008921	active site
232721008922	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721008923	putative DNA binding site [nucleotide binding]; other site
232721008924	putative Zn2+ binding site [ion binding]; other site
232721008925	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
232721008926	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
232721008927	putative acyl-acceptor binding pocket; other site
232721008928	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
232721008929	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
232721008930	Walker A/P-loop; other site
232721008931	ATP binding site [chemical binding]; other site
232721008932	Q-loop/lid; other site
232721008933	ABC transporter signature motif; other site
232721008934	Walker B; other site
232721008935	D-loop; other site
232721008936	H-loop/switch region; other site
232721008937	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
232721008938	Fatty acid desaturase; Region: FA_desaturase; pfam00487
232721008939	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
232721008940	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
232721008941	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
232721008942	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
232721008943	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
232721008944	putative active site [active]
232721008945	putative metal binding site [ion binding]; other site
232721008946	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
232721008947	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
232721008948	nucleotide binding site/active site [active]
232721008949	HIT family signature motif; other site
232721008950	catalytic residue [active]
232721008951	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
232721008952	Predicted permeases [General function prediction only]; Region: COG0795
232721008953	Predicted permeases [General function prediction only]; Region: COG0795
232721008954	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
232721008955	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
232721008956	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
232721008957	active site
232721008958	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
232721008959	active site
232721008960	metal-binding site
232721008961	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
232721008962	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
232721008963	Cytochrome P450; Region: p450; cl12078
232721008964	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
232721008965	acyl-CoA synthetase; Validated; Region: PRK09192
232721008966	The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908
232721008967	acyl-activating enzyme (AAE) consensus motif; other site
232721008968	putative AMP binding site [chemical binding]; other site
232721008969	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
232721008970	acyl-CoA synthetase; Validated; Region: PRK09192
232721008971	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
232721008972	acyl-activating enzyme (AAE) consensus motif; other site
232721008973	active site
232721008974	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
232721008975	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
232721008976	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
232721008977	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721008978	catalytic residue [active]
232721008979	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
232721008980	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
232721008981	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
232721008982	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
232721008983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721008984	NAD(P) binding site [chemical binding]; other site
232721008985	active site
232721008986	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
232721008987	nucleoside/Zn binding site; other site
232721008988	dimer interface [polypeptide binding]; other site
232721008989	catalytic motif [active]
232721008990	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721008991	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721008992	Walker A motif; other site
232721008993	ATP binding site [chemical binding]; other site
232721008994	Walker B motif; other site
232721008995	Homeodomain-like domain; Region: HTH_23; pfam13384
232721008996	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721008997	Integrase core domain; Region: rve; pfam00665
232721008998	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721008999	dimerization interface [polypeptide binding]; other site
232721009000	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721009001	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721009002	dimer interface [polypeptide binding]; other site
232721009003	putative CheW interface [polypeptide binding]; other site
232721009004	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721009005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721009006	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
232721009007	substrate binding pocket [chemical binding]; other site
232721009008	dimerization interface [polypeptide binding]; other site
232721009009	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
232721009010	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
232721009011	catalytic loop [active]
232721009012	iron binding site [ion binding]; other site
232721009013	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
232721009014	FAD binding pocket [chemical binding]; other site
232721009015	FAD binding motif [chemical binding]; other site
232721009016	phosphate binding motif [ion binding]; other site
232721009017	beta-alpha-beta structure motif; other site
232721009018	NAD binding pocket [chemical binding]; other site
232721009019	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
232721009020	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
232721009021	iron-sulfur cluster [ion binding]; other site
232721009022	[2Fe-2S] cluster binding site [ion binding]; other site
232721009023	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
232721009024	[2Fe-2S] cluster binding site [ion binding]; other site
232721009025	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
232721009026	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
232721009027	iron-sulfur cluster [ion binding]; other site
232721009028	[2Fe-2S] cluster binding site [ion binding]; other site
232721009029	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
232721009030	beta subunit interface [polypeptide binding]; other site
232721009031	alpha subunit interface [polypeptide binding]; other site
232721009032	active site
232721009033	substrate binding site [chemical binding]; other site
232721009034	Fe binding site [ion binding]; other site
232721009035	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
232721009036	inter-subunit interface; other site
232721009037	Transposase domain (DUF772); Region: DUF772; pfam05598
232721009038	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721009039	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721009040	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721009041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721009042	Walker A motif; other site
232721009043	ATP binding site [chemical binding]; other site
232721009044	Walker B motif; other site
232721009045	arginine finger; other site
232721009046	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721009047	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
232721009048	Integrase core domain; Region: rve; pfam00665
232721009049	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4603
232721009050	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
232721009051	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
232721009052	Walker A/P-loop; other site
232721009053	ATP binding site [chemical binding]; other site
232721009054	Q-loop/lid; other site
232721009055	ABC transporter signature motif; other site
232721009056	Walker B; other site
232721009057	D-loop; other site
232721009058	H-loop/switch region; other site
232721009059	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
232721009060	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
232721009061	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
232721009062	catalytic loop [active]
232721009063	iron binding site [ion binding]; other site
232721009064	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
232721009065	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
232721009066	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
232721009067	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
232721009068	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
232721009069	PAS domain; Region: PAS_9; pfam13426
232721009070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721009071	putative active site [active]
232721009072	heme pocket [chemical binding]; other site
232721009073	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721009074	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721009075	metal binding site [ion binding]; metal-binding site
232721009076	active site
232721009077	I-site; other site
232721009078	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
232721009079	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
232721009080	ligand binding site [chemical binding]; other site
232721009081	flexible hinge region; other site
232721009082	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
232721009083	putative switch regulator; other site
232721009084	non-specific DNA interactions [nucleotide binding]; other site
232721009085	DNA binding site [nucleotide binding]
232721009086	sequence specific DNA binding site [nucleotide binding]; other site
232721009087	putative cAMP binding site [chemical binding]; other site
232721009088	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
232721009089	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
232721009090	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721009091	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721009092	metal binding site [ion binding]; metal-binding site
232721009093	active site
232721009094	I-site; other site
232721009095	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
232721009096	HIT family signature motif; other site
232721009097	catalytic residue [active]
232721009098	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
232721009099	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
232721009100	putative ligand binding site [chemical binding]; other site
232721009101	NAD binding site [chemical binding]; other site
232721009102	catalytic site [active]
232721009103	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
232721009104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721009105	putative substrate translocation pore; other site
232721009106	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
232721009107	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
232721009108	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
232721009109	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
232721009110	Walker A/P-loop; other site
232721009111	ATP binding site [chemical binding]; other site
232721009112	Q-loop/lid; other site
232721009113	ABC transporter signature motif; other site
232721009114	Walker B; other site
232721009115	D-loop; other site
232721009116	H-loop/switch region; other site
232721009117	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
232721009118	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
232721009119	putative dimer interface [polypeptide binding]; other site
232721009120	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
232721009121	FtsX-like permease family; Region: FtsX; pfam02687
232721009122	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
232721009123	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
232721009124	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721009125	catalytic residue [active]
232721009126	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
232721009127	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
232721009128	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
232721009129	TM-ABC transporter signature motif; other site
232721009130	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
232721009131	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
232721009132	TM-ABC transporter signature motif; other site
232721009133	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
232721009134	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
232721009135	putative ligand binding site [chemical binding]; other site
232721009136	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
232721009137	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
232721009138	putative ligand binding site [chemical binding]; other site
232721009139	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
232721009140	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
232721009141	Walker A/P-loop; other site
232721009142	ATP binding site [chemical binding]; other site
232721009143	Q-loop/lid; other site
232721009144	ABC transporter signature motif; other site
232721009145	Walker B; other site
232721009146	D-loop; other site
232721009147	H-loop/switch region; other site
232721009148	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
232721009149	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
232721009150	Walker A/P-loop; other site
232721009151	ATP binding site [chemical binding]; other site
232721009152	Q-loop/lid; other site
232721009153	ABC transporter signature motif; other site
232721009154	Walker B; other site
232721009155	D-loop; other site
232721009156	H-loop/switch region; other site
232721009157	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
232721009158	TOBE domain; Region: TOBE; cl01440
232721009159	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
232721009160	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
232721009161	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
232721009162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721009163	putative PBP binding loops; other site
232721009164	dimer interface [polypeptide binding]; other site
232721009165	ABC-ATPase subunit interface; other site
232721009166	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721009167	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
232721009168	Walker A/P-loop; other site
232721009169	ATP binding site [chemical binding]; other site
232721009170	Q-loop/lid; other site
232721009171	ABC transporter signature motif; other site
232721009172	Walker B; other site
232721009173	D-loop; other site
232721009174	H-loop/switch region; other site
232721009175	TOBE domain; Region: TOBE; pfam03459
232721009176	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
232721009177	PBP superfamily domain; Region: PBP_like_2; pfam12849
232721009178	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
232721009179	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
232721009180	Walker A/P-loop; other site
232721009181	ATP binding site [chemical binding]; other site
232721009182	Q-loop/lid; other site
232721009183	ABC transporter signature motif; other site
232721009184	Walker B; other site
232721009185	D-loop; other site
232721009186	H-loop/switch region; other site
232721009187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
232721009188	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
232721009189	PBP superfamily domain; Region: PBP_like; pfam12727
232721009190	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
232721009191	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
232721009192	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
232721009193	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
232721009194	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
232721009195	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
232721009196	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
232721009197	acyl-CoA synthetase; Validated; Region: PRK08162
232721009198	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
232721009199	acyl-activating enzyme (AAE) consensus motif; other site
232721009200	putative active site [active]
232721009201	AMP binding site [chemical binding]; other site
232721009202	putative CoA binding site [chemical binding]; other site
232721009203	DNA primase, catalytic core; Region: dnaG; TIGR01391
232721009204	CHC2 zinc finger; Region: zf-CHC2; pfam01807
232721009205	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
232721009206	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
232721009207	active site
232721009208	metal binding site [ion binding]; metal-binding site
232721009209	interdomain interaction site; other site
232721009210	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
232721009211	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
232721009212	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
232721009213	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
232721009214	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
232721009215	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
232721009216	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
232721009217	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
232721009218	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
232721009219	DNA binding residues [nucleotide binding]
232721009220	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
232721009221	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
232721009222	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
232721009223	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
232721009224	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721009225	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
232721009226	CoA-transferase family III; Region: CoA_transf_3; pfam02515
232721009227	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
232721009228	active site
232721009229	catalytic residues [active]
232721009230	metal binding site [ion binding]; metal-binding site
232721009231	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721009232	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721009233	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
232721009234	putative dimerization interface [polypeptide binding]; other site
232721009235	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
232721009236	dimerization interface [polypeptide binding]; other site
232721009237	putative DNA binding site [nucleotide binding]; other site
232721009238	Predicted transcriptional regulators [Transcription]; Region: COG1733
232721009239	putative Zn2+ binding site [ion binding]; other site
232721009240	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
232721009241	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
232721009242	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
232721009243	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
232721009244	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
232721009245	FeS/SAM binding site; other site
232721009246	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
232721009247	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
232721009248	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
232721009249	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
232721009250	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
232721009251	HD domain; Region: HD_4; pfam13328
232721009252	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
232721009253	synthetase active site [active]
232721009254	NTP binding site [chemical binding]; other site
232721009255	metal binding site [ion binding]; metal-binding site
232721009256	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
232721009257	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
232721009258	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
232721009259	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
232721009260	d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940
232721009261	NAD binding site [chemical binding]; other site
232721009262	homotetramer interface [polypeptide binding]; other site
232721009263	homodimer interface [polypeptide binding]; other site
232721009264	substrate binding site [chemical binding]; other site
232721009265	active site
232721009266	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
232721009267	osmolarity response regulator; Provisional; Region: ompR; PRK09468
232721009268	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721009269	active site
232721009270	phosphorylation site [posttranslational modification]
232721009271	intermolecular recognition site; other site
232721009272	dimerization interface [polypeptide binding]; other site
232721009273	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721009274	DNA binding site [nucleotide binding]
232721009275	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
232721009276	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721009277	dimerization interface [polypeptide binding]; other site
232721009278	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721009279	dimer interface [polypeptide binding]; other site
232721009280	phosphorylation site [posttranslational modification]
232721009281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721009282	ATP binding site [chemical binding]; other site
232721009283	Mg2+ binding site [ion binding]; other site
232721009284	G-X-G motif; other site
232721009285	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
232721009286	homotrimer interaction site [polypeptide binding]; other site
232721009287	zinc binding site [ion binding]; other site
232721009288	CDP-binding sites; other site
232721009289	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
232721009290	substrate binding site; other site
232721009291	dimer interface; other site
232721009292	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
232721009293	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
232721009294	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721009295	ATP binding site [chemical binding]; other site
232721009296	putative Mg++ binding site [ion binding]; other site
232721009297	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721009298	nucleotide binding region [chemical binding]; other site
232721009299	ATP-binding site [chemical binding]; other site
232721009300	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
232721009301	Predicted membrane protein [Function unknown]; Region: COG3235
232721009302	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
232721009303	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
232721009304	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
232721009305	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
232721009306	Lysine efflux permease [General function prediction only]; Region: COG1279
232721009307	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
232721009308	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721009309	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721009310	dimerization interface [polypeptide binding]; other site
232721009311	Predicted transcriptional regulator [Transcription]; Region: COG1959
232721009312	Transcriptional regulator; Region: Rrf2; cl17282
232721009313	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
232721009314	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
232721009315	Hemerythrin-like domain; Region: Hr-like; cd12108
232721009316	Fe binding site [ion binding]; other site
232721009317	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
232721009318	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
232721009319	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
232721009320	active site
232721009321	catalytic tetrad [active]
232721009322	SlyX; Region: SlyX; pfam04102
232721009323	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
232721009324	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721009325	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721009326	homodimer interface [polypeptide binding]; other site
232721009327	catalytic residue [active]
232721009328	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
232721009329	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
232721009330	minor groove reading motif; other site
232721009331	helix-hairpin-helix signature motif; other site
232721009332	substrate binding pocket [chemical binding]; other site
232721009333	active site
232721009334	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
232721009335	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
232721009336	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
232721009337	NodB motif; other site
232721009338	putative active site [active]
232721009339	putative catalytic site [active]
232721009340	putative Zn binding site [ion binding]; other site
232721009341	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
232721009342	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
232721009343	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
232721009344	putative dimer interface [polypeptide binding]; other site
232721009345	active site pocket [active]
232721009346	putative cataytic base [active]
232721009347	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
232721009348	putative FMN binding site [chemical binding]; other site
232721009349	cobyric acid synthase; Provisional; Region: PRK00784
232721009350	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
232721009351	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
232721009352	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
232721009353	catalytic triad [active]
232721009354	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
232721009355	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
232721009356	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721009357	catalytic residue [active]
232721009358	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
232721009359	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
232721009360	Type II transport protein GspH; Region: GspH; pfam12019
232721009361	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
232721009362	Type II transport protein GspH; Region: GspH; pfam12019
232721009363	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
232721009364	Transposase domain (DUF772); Region: DUF772; pfam05598
232721009365	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721009366	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721009367	Type IV pilus assembly protein PilX C-term; Region: PilX; pfam13681
232721009368	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
232721009369	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
232721009370	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
232721009371	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
232721009372	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
232721009373	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
232721009374	catalytic motif [active]
232721009375	Zn binding site [ion binding]; other site
232721009376	RibD C-terminal domain; Region: RibD_C; cl17279
232721009377	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
232721009378	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
232721009379	putative active site [active]
232721009380	catalytic site [active]
232721009381	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
232721009382	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
232721009383	putative active site [active]
232721009384	catalytic site [active]
232721009385	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
232721009386	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
232721009387	FMN binding site [chemical binding]; other site
232721009388	active site
232721009389	catalytic residues [active]
232721009390	substrate binding site [chemical binding]; other site
232721009391	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
232721009392	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
232721009393	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
232721009394	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
232721009395	Coenzyme A binding pocket [chemical binding]; other site
232721009396	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
232721009397	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
232721009398	NAD(P) binding site [chemical binding]; other site
232721009399	catalytic residues [active]
232721009400	Uncharacterized conserved protein [Function unknown]; Region: COG3791
232721009401	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
232721009402	Clp amino terminal domain; Region: Clp_N; pfam02861
232721009403	Clp amino terminal domain; Region: Clp_N; pfam02861
232721009404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721009405	Walker A motif; other site
232721009406	ATP binding site [chemical binding]; other site
232721009407	Walker B motif; other site
232721009408	arginine finger; other site
232721009409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721009410	Walker A motif; other site
232721009411	ATP binding site [chemical binding]; other site
232721009412	Walker B motif; other site
232721009413	arginine finger; other site
232721009414	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
232721009415	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
232721009416	MoaE homodimer interface [polypeptide binding]; other site
232721009417	MoaD interaction [polypeptide binding]; other site
232721009418	active site residues [active]
232721009419	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
232721009420	MoaE interaction surface [polypeptide binding]; other site
232721009421	MoeB interaction surface [polypeptide binding]; other site
232721009422	thiocarboxylated glycine; other site
232721009423	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
232721009424	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
232721009425	dimer interface [polypeptide binding]; other site
232721009426	putative functional site; other site
232721009427	putative MPT binding site; other site
232721009428	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
232721009429	Walker A motif; other site
232721009430	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
232721009431	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
232721009432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721009433	catalytic residue [active]
232721009434	homoserine dehydrogenase; Provisional; Region: PRK06349
232721009435	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
232721009436	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
232721009437	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
232721009438	aminotransferase AlaT; Validated; Region: PRK09265
232721009439	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721009440	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721009441	homodimer interface [polypeptide binding]; other site
232721009442	catalytic residue [active]
232721009443	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
232721009444	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
232721009445	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
232721009446	catalytic triad [active]
232721009447	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
232721009448	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
232721009449	putative active site [active]
232721009450	PhoH-like protein; Region: PhoH; pfam02562
232721009451	replicative DNA helicase; Region: DnaB; TIGR00665
232721009452	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
232721009453	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
232721009454	Walker A motif; other site
232721009455	ATP binding site [chemical binding]; other site
232721009456	Walker B motif; other site
232721009457	DNA binding loops [nucleotide binding]
232721009458	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
232721009459	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
232721009460	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
232721009461	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
232721009462	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
232721009463	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
232721009464	GrpE; Region: GrpE; pfam01025
232721009465	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
232721009466	dimer interface [polypeptide binding]; other site
232721009467	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
232721009468	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
232721009469	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
232721009470	nucleotide binding site [chemical binding]; other site
232721009471	chaperone protein DnaJ; Provisional; Region: PRK10767
232721009472	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
232721009473	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
232721009474	substrate binding site [polypeptide binding]; other site
232721009475	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
232721009476	Zn binding sites [ion binding]; other site
232721009477	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
232721009478	dimer interface [polypeptide binding]; other site
232721009479	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
232721009480	Peptidase family U32; Region: Peptidase_U32; pfam01136
232721009481	putative protease; Provisional; Region: PRK15447
232721009482	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
232721009483	SCP-2 sterol transfer family; Region: SCP2; cl01225
232721009484	DGC domain; Region: DGC; pfam08859
232721009485	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
232721009486	Flavoprotein; Region: Flavoprotein; pfam02441
232721009487	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
232721009488	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
232721009489	Cytochrome P450; Region: p450; cl12078
232721009490	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
232721009491	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
232721009492	Beta-Casp domain; Region: Beta-Casp; smart01027
232721009493	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
232721009494	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721009495	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721009496	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
232721009497	putative dimerization interface [polypeptide binding]; other site
232721009498	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
232721009499	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
232721009500	substrate binding site [chemical binding]; other site
232721009501	ligand binding site [chemical binding]; other site
232721009502	Entericidin EcnA/B family; Region: Entericidin; pfam08085
232721009503	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
232721009504	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
232721009505	substrate binding site [chemical binding]; other site
232721009506	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
232721009507	tartrate dehydrogenase; Region: TTC; TIGR02089
232721009508	short chain dehydrogenase; Provisional; Region: PRK07478
232721009509	classical (c) SDRs; Region: SDR_c; cd05233
232721009510	NAD(P) binding site [chemical binding]; other site
232721009511	active site
232721009512	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
232721009513	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
232721009514	FimV N-terminal domain; Region: FimV_core; TIGR03505
232721009515	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
232721009516	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
232721009517	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
232721009518	dimerization interface 3.5A [polypeptide binding]; other site
232721009519	active site
232721009520	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
232721009521	active site
232721009522	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
232721009523	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
232721009524	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721009525	catalytic residue [active]
232721009526	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
232721009527	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
232721009528	substrate binding site [chemical binding]; other site
232721009529	active site
232721009530	catalytic residues [active]
232721009531	heterodimer interface [polypeptide binding]; other site
232721009532	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
232721009533	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
232721009534	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
232721009535	YGGT family; Region: YGGT; pfam02325
232721009536	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
232721009537	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721009538	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
232721009539	putative ADP-binding pocket [chemical binding]; other site
232721009540	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
232721009541	Bacterial sugar transferase; Region: Bac_transf; pfam02397
232721009542	Methyltransferase domain; Region: Methyltransf_12; pfam08242
232721009543	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
232721009544	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
232721009545	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
232721009546	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
232721009547	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
232721009548	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
232721009549	dimer interface [polypeptide binding]; other site
232721009550	putative anticodon binding site; other site
232721009551	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
232721009552	motif 1; other site
232721009553	active site
232721009554	motif 2; other site
232721009555	motif 3; other site
232721009556	Response regulator receiver domain; Region: Response_reg; pfam00072
232721009557	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721009558	active site
232721009559	phosphorylation site [posttranslational modification]
232721009560	intermolecular recognition site; other site
232721009561	dimerization interface [polypeptide binding]; other site
232721009562	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721009563	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721009564	metal binding site [ion binding]; metal-binding site
232721009565	active site
232721009566	I-site; other site
232721009567	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
232721009568	Mechanosensitive ion channel; Region: MS_channel; pfam00924
232721009569	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
232721009570	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
232721009571	dimerization interface [polypeptide binding]; other site
232721009572	ligand binding site [chemical binding]; other site
232721009573	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
232721009574	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
232721009575	TM-ABC transporter signature motif; other site
232721009576	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
232721009577	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
232721009578	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
232721009579	TM-ABC transporter signature motif; other site
232721009580	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
232721009581	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
232721009582	Walker A/P-loop; other site
232721009583	ATP binding site [chemical binding]; other site
232721009584	Q-loop/lid; other site
232721009585	ABC transporter signature motif; other site
232721009586	Walker B; other site
232721009587	D-loop; other site
232721009588	H-loop/switch region; other site
232721009589	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
232721009590	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
232721009591	Walker A/P-loop; other site
232721009592	ATP binding site [chemical binding]; other site
232721009593	Q-loop/lid; other site
232721009594	ABC transporter signature motif; other site
232721009595	Walker B; other site
232721009596	D-loop; other site
232721009597	H-loop/switch region; other site
232721009598	Uncharacterized conserved protein [Function unknown]; Region: COG2128
232721009599	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
232721009600	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
232721009601	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
232721009602	active site
232721009603	ADP/pyrophosphate binding site [chemical binding]; other site
232721009604	dimerization interface [polypeptide binding]; other site
232721009605	allosteric effector site; other site
232721009606	fructose-1,6-bisphosphate binding site; other site
232721009607	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
232721009608	beta-hexosaminidase; Provisional; Region: PRK05337
232721009609	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
232721009610	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
232721009611	active site
232721009612	hydrophilic channel; other site
232721009613	dimerization interface [polypeptide binding]; other site
232721009614	catalytic residues [active]
232721009615	active site lid [active]
232721009616	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
232721009617	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
232721009618	Recombination protein O N terminal; Region: RecO_N; pfam11967
232721009619	GTPase Era; Reviewed; Region: era; PRK00089
232721009620	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
232721009621	G1 box; other site
232721009622	GTP/Mg2+ binding site [chemical binding]; other site
232721009623	Switch I region; other site
232721009624	G2 box; other site
232721009625	Switch II region; other site
232721009626	G3 box; other site
232721009627	G4 box; other site
232721009628	G5 box; other site
232721009629	KH domain; Region: KH_2; pfam07650
232721009630	ribonuclease III; Reviewed; Region: rnc; PRK00102
232721009631	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
232721009632	dimerization interface [polypeptide binding]; other site
232721009633	active site
232721009634	metal binding site [ion binding]; metal-binding site
232721009635	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
232721009636	signal peptidase I; Provisional; Region: PRK10861
232721009637	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
232721009638	Catalytic site [active]
232721009639	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
232721009640	GTP-binding protein LepA; Provisional; Region: PRK05433
232721009641	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
232721009642	G1 box; other site
232721009643	putative GEF interaction site [polypeptide binding]; other site
232721009644	GTP/Mg2+ binding site [chemical binding]; other site
232721009645	Switch I region; other site
232721009646	G2 box; other site
232721009647	G3 box; other site
232721009648	Switch II region; other site
232721009649	G4 box; other site
232721009650	G5 box; other site
232721009651	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
232721009652	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
232721009653	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
232721009654	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
232721009655	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
232721009656	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
232721009657	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
232721009658	protein binding site [polypeptide binding]; other site
232721009659	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
232721009660	anti-sigma E factor; Provisional; Region: rseB; PRK09455
232721009661	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
232721009662	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
232721009663	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
232721009664	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
232721009665	DNA binding residues [nucleotide binding]
232721009666	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
232721009667	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
232721009668	dimer interface [polypeptide binding]; other site
232721009669	active site
232721009670	acyl carrier protein; Provisional; Region: acpP; PRK00982
232721009671	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721009672	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
232721009673	NAD(P) binding site [chemical binding]; other site
232721009674	active site
232721009675	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
232721009676	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
232721009677	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
232721009678	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
232721009679	dimer interface [polypeptide binding]; other site
232721009680	active site
232721009681	CoA binding pocket [chemical binding]; other site
232721009682	putative phosphate acyltransferase; Provisional; Region: PRK05331
232721009683	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
232721009684	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
232721009685	Maf-like protein; Region: Maf; pfam02545
232721009686	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
232721009687	active site
232721009688	dimer interface [polypeptide binding]; other site
232721009689	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
232721009690	putative SAM binding site [chemical binding]; other site
232721009691	homodimer interface [polypeptide binding]; other site
232721009692	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
232721009693	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
232721009694	tandem repeat interface [polypeptide binding]; other site
232721009695	oligomer interface [polypeptide binding]; other site
232721009696	active site residues [active]
232721009697	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
232721009698	iron-sulfur cluster [ion binding]; other site
232721009699	[2Fe-2S] cluster binding site [ion binding]; other site
232721009700	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
232721009701	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721009702	motif II; other site
232721009703	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
232721009704	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
232721009705	homodimer interface [polypeptide binding]; other site
232721009706	oligonucleotide binding site [chemical binding]; other site
232721009707	hypothetical protein; Validated; Region: PRK02101
232721009708	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
232721009709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
232721009710	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
232721009711	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
232721009712	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721009713	PAS domain; Region: PAS_9; pfam13426
232721009714	putative active site [active]
232721009715	heme pocket [chemical binding]; other site
232721009716	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721009717	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721009718	dimer interface [polypeptide binding]; other site
232721009719	putative CheW interface [polypeptide binding]; other site
232721009720	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
232721009721	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
232721009722	active site
232721009723	DNA binding site [nucleotide binding]
232721009724	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
232721009725	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
232721009726	phosphate binding site [ion binding]; other site
232721009727	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
232721009728	Transglycosylase; Region: Transgly; pfam00912
232721009729	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
232721009730	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
232721009731	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
232721009732	substrate binding site [chemical binding]; other site
232721009733	Uncharacterized conserved protein [Function unknown]; Region: COG3339
232721009734	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
232721009735	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
232721009736	putative catalytic site [active]
232721009737	putative metal binding site [ion binding]; other site
232721009738	putative phosphate binding site [ion binding]; other site
232721009739	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
232721009740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721009741	dimer interface [polypeptide binding]; other site
232721009742	conserved gate region; other site
232721009743	putative PBP binding loops; other site
232721009744	ABC-ATPase subunit interface; other site
232721009745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721009746	dimer interface [polypeptide binding]; other site
232721009747	conserved gate region; other site
232721009748	putative PBP binding loops; other site
232721009749	ABC-ATPase subunit interface; other site
232721009750	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
232721009751	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
232721009752	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
232721009753	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721009754	Walker A/P-loop; other site
232721009755	ATP binding site [chemical binding]; other site
232721009756	Q-loop/lid; other site
232721009757	ABC transporter signature motif; other site
232721009758	Walker B; other site
232721009759	D-loop; other site
232721009760	H-loop/switch region; other site
232721009761	BCCT family transporter; Region: BCCT; pfam02028
232721009762	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
232721009763	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
232721009764	MG2 domain; Region: A2M_N; pfam01835
232721009765	Alpha-2-macroglobulin family; Region: A2M; pfam00207
232721009766	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
232721009767	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
232721009768	tetramer interface [polypeptide binding]; other site
232721009769	heme binding pocket [chemical binding]; other site
232721009770	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
232721009771	domain interactions; other site
232721009772	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721009773	argininosuccinate lyase; Provisional; Region: PRK00855
232721009774	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
232721009775	active sites [active]
232721009776	tetramer interface [polypeptide binding]; other site
232721009777	Histidine kinase; Region: His_kinase; pfam06580
232721009778	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
232721009779	Mg2+ binding site [ion binding]; other site
232721009780	G-X-G motif; other site
232721009781	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
232721009782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721009783	active site
232721009784	phosphorylation site [posttranslational modification]
232721009785	intermolecular recognition site; other site
232721009786	dimerization interface [polypeptide binding]; other site
232721009787	LytTr DNA-binding domain; Region: LytTR; smart00850
232721009788	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
232721009789	Dienelactone hydrolase family; Region: DLH; pfam01738
232721009790	DNA polymerase I; Provisional; Region: PRK05755
232721009791	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
232721009792	active site
232721009793	metal binding site 1 [ion binding]; metal-binding site
232721009794	putative 5' ssDNA interaction site; other site
232721009795	metal binding site 3; metal-binding site
232721009796	metal binding site 2 [ion binding]; metal-binding site
232721009797	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
232721009798	putative DNA binding site [nucleotide binding]; other site
232721009799	putative metal binding site [ion binding]; other site
232721009800	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
232721009801	active site
232721009802	catalytic site [active]
232721009803	substrate binding site [chemical binding]; other site
232721009804	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
232721009805	active site
232721009806	DNA binding site [nucleotide binding]
232721009807	catalytic site [active]
232721009808	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
232721009809	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
232721009810	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
232721009811	putative active site [active]
232721009812	putative substrate binding site [chemical binding]; other site
232721009813	ATP binding site [chemical binding]; other site
232721009814	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
232721009815	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
232721009816	ligand binding site [chemical binding]; other site
232721009817	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
232721009818	Part of AAA domain; Region: AAA_19; pfam13245
232721009819	Family description; Region: UvrD_C_2; pfam13538
232721009820	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
232721009821	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
232721009822	active site
232721009823	Transposase domain (DUF772); Region: DUF772; pfam05598
232721009824	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721009825	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721009826	Helix-turn-helix domain; Region: HTH_39; pfam14090
232721009827	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
232721009828	Protein of unknown function (DUF497); Region: DUF497; pfam04365
232721009829	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
232721009830	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
232721009831	active site
232721009832	catalytic residues [active]
232721009833	DNA binding site [nucleotide binding]
232721009834	Int/Topo IB signature motif; other site
232721009835	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
232721009836	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
232721009837	ligand binding site [chemical binding]; other site
232721009838	flexible hinge region; other site
232721009839	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
232721009840	Protein of unknown function (DUF461); Region: DUF461; pfam04314
232721009841	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
232721009842	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721009843	putative substrate translocation pore; other site
232721009844	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
232721009845	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
232721009846	ATP binding site [chemical binding]; other site
232721009847	Mg++ binding site [ion binding]; other site
232721009848	motif III; other site
232721009849	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721009850	nucleotide binding region [chemical binding]; other site
232721009851	ATP-binding site [chemical binding]; other site
232721009852	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
232721009853	catalytic site [active]
232721009854	putative active site [active]
232721009855	putative substrate binding site [chemical binding]; other site
232721009856	dimer interface [polypeptide binding]; other site
232721009857	Peptidase family M48; Region: Peptidase_M48; pfam01435
232721009858	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
232721009859	aromatic arch; other site
232721009860	DCoH dimer interaction site [polypeptide binding]; other site
232721009861	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
232721009862	DCoH tetramer interaction site [polypeptide binding]; other site
232721009863	substrate binding site [chemical binding]; other site
232721009864	GTPase RsgA; Reviewed; Region: PRK00098
232721009865	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
232721009866	RNA binding site [nucleotide binding]; other site
232721009867	homodimer interface [polypeptide binding]; other site
232721009868	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
232721009869	GTPase/Zn-binding domain interface [polypeptide binding]; other site
232721009870	GTP/Mg2+ binding site [chemical binding]; other site
232721009871	G4 box; other site
232721009872	G5 box; other site
232721009873	G1 box; other site
232721009874	Switch I region; other site
232721009875	G2 box; other site
232721009876	G3 box; other site
232721009877	Switch II region; other site
232721009878	CobD/Cbib protein; Region: CobD_Cbib; cl00561
232721009879	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
232721009880	putative active site [active]
232721009881	putative CoA binding site [chemical binding]; other site
232721009882	nudix motif; other site
232721009883	metal binding site [ion binding]; metal-binding site
232721009884	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
232721009885	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
232721009886	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
232721009887	RimM N-terminal domain; Region: RimM; pfam01782
232721009888	PRC-barrel domain; Region: PRC; pfam05239
232721009889	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
232721009890	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
232721009891	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
232721009892	Coenzyme A binding pocket [chemical binding]; other site
232721009893	TM2 domain; Region: TM2; pfam05154
232721009894	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
232721009895	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
232721009896	Protein of unknown function, DUF486; Region: DUF486; pfam04342
232721009897	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
232721009898	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
232721009899	Walker A/P-loop; other site
232721009900	ATP binding site [chemical binding]; other site
232721009901	Q-loop/lid; other site
232721009902	ABC transporter signature motif; other site
232721009903	Walker B; other site
232721009904	D-loop; other site
232721009905	H-loop/switch region; other site
232721009906	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
232721009907	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
232721009908	Walker A/P-loop; other site
232721009909	ATP binding site [chemical binding]; other site
232721009910	Q-loop/lid; other site
232721009911	ABC transporter signature motif; other site
232721009912	Walker B; other site
232721009913	D-loop; other site
232721009914	H-loop/switch region; other site
232721009915	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
232721009916	TM-ABC transporter signature motif; other site
232721009917	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
232721009918	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
232721009919	TM-ABC transporter signature motif; other site
232721009920	recombination factor protein RarA; Reviewed; Region: PRK13342
232721009921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721009922	Walker A motif; other site
232721009923	ATP binding site [chemical binding]; other site
232721009924	Walker B motif; other site
232721009925	arginine finger; other site
232721009926	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
232721009927	integron integrase; Region: integrase_gron; TIGR02249
232721009928	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
232721009929	Int/Topo IB signature motif; other site
232721009930	Transposase domain (DUF772); Region: DUF772; pfam05598
232721009931	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721009932	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721009933	Protein of unknown function (DUF1010); Region: DUF1010; pfam06231
232721009934	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721009935	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721009936	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721009937	Protein of unknown function (DUF1010); Region: DUF1010; pfam06231
232721009938	Protein of unknown function (DUF1010); Region: DUF1010; pfam06231
232721009939	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721009940	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721009941	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721009942	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721009943	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721009944	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721009945	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721009946	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721009947	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721009948	Protein of unknown function, DUF488; Region: DUF488; cl01246
232721009949	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
232721009950	ligand binding site [chemical binding]; other site
232721009951	active site
232721009952	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
232721009953	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
232721009954	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
232721009955	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
232721009956	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
232721009957	thioredoxin reductase; Provisional; Region: PRK10262
232721009958	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
232721009959	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721009960	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
232721009961	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
232721009962	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
232721009963	Fatty acid desaturase; Region: FA_desaturase; pfam00487
232721009964	Di-iron ligands [ion binding]; other site
232721009965	Transposase; Region: DDE_Tnp_ISL3; pfam01610
232721009966	16S rRNA methyltransferase B; Provisional; Region: PRK14902
232721009967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721009968	S-adenosylmethionine binding site [chemical binding]; other site
232721009969	Peptidase family M48; Region: Peptidase_M48; cl12018
232721009970	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
232721009971	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
232721009972	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
232721009973	active site
232721009974	substrate binding site [chemical binding]; other site
232721009975	cosubstrate binding site; other site
232721009976	catalytic site [active]
232721009977	hypothetical protein; Provisional; Region: PRK11239
232721009978	Protein of unknown function, DUF480; Region: DUF480; pfam04337
232721009979	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
232721009980	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721009981	active site
232721009982	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
232721009983	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
232721009984	active site
232721009985	Transposase domain (DUF772); Region: DUF772; pfam05598
232721009986	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721009987	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721009988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
232721009989	binding surface
232721009990	Tetratricopeptide repeat; Region: TPR_16; pfam13432
232721009991	TPR motif; other site
232721009992	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
232721009993	TPR motif; other site
232721009994	binding surface
232721009995	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
232721009996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
232721009997	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
232721009998	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
232721009999	active site
232721010000	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
232721010001	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
232721010002	active site
232721010003	Riboflavin kinase; Region: Flavokinase; smart00904
232721010004	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
232721010005	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
232721010006	active site
232721010007	HIGH motif; other site
232721010008	nucleotide binding site [chemical binding]; other site
232721010009	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
232721010010	active site
232721010011	KMSKS motif; other site
232721010012	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
232721010013	tRNA binding surface [nucleotide binding]; other site
232721010014	anticodon binding site; other site
232721010015	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
232721010016	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
232721010017	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
232721010018	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
232721010019	PhoU domain; Region: PhoU; pfam01895
232721010020	PhoU domain; Region: PhoU; pfam01895
232721010021	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
232721010022	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
232721010023	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721010024	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721010025	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721010026	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
232721010027	nudix motif; other site
232721010028	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
232721010029	EamA-like transporter family; Region: EamA; pfam00892
232721010030	EamA-like transporter family; Region: EamA; pfam00892
232721010031	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
232721010032	Transposase domain (DUF772); Region: DUF772; pfam05598
232721010033	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721010034	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721010035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
232721010036	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
232721010037	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
232721010038	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
232721010039	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
232721010040	Walker A motif; other site
232721010041	ATP binding site [chemical binding]; other site
232721010042	Walker B motif; other site
232721010043	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
232721010044	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
232721010045	putative active site [active]
232721010046	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
232721010047	active site
232721010048	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
232721010049	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721010050	dimerization interface [polypeptide binding]; other site
232721010051	putative DNA binding site [nucleotide binding]; other site
232721010052	putative Zn2+ binding site [ion binding]; other site
232721010053	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
232721010054	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
232721010055	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
232721010056	Walker A/P-loop; other site
232721010057	ATP binding site [chemical binding]; other site
232721010058	Q-loop/lid; other site
232721010059	ABC transporter signature motif; other site
232721010060	Walker B; other site
232721010061	D-loop; other site
232721010062	H-loop/switch region; other site
232721010063	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
232721010064	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
232721010065	FtsX-like permease family; Region: FtsX; pfam02687
232721010066	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
232721010067	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
232721010068	putative active site [active]
232721010069	catalytic site [active]
232721010070	putative metal binding site [ion binding]; other site
232721010071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
232721010072	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
232721010073	DHH family; Region: DHH; pfam01368
232721010074	DHHA1 domain; Region: DHHA1; pfam02272
232721010075	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
232721010076	Transposase domain (DUF772); Region: DUF772; pfam05598
232721010077	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721010078	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721010079	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
232721010080	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
232721010081	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721010082	dimerization interface [polypeptide binding]; other site
232721010083	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721010084	dimer interface [polypeptide binding]; other site
232721010085	putative CheW interface [polypeptide binding]; other site
232721010086	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
232721010087	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
232721010088	active site
232721010089	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
232721010090	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
232721010091	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
232721010092	metal ion-dependent adhesion site (MIDAS); other site
232721010093	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721010094	MoxR-like ATPases [General function prediction only]; Region: COG0714
232721010095	Walker A motif; other site
232721010096	ATP binding site [chemical binding]; other site
232721010097	Walker B motif; other site
232721010098	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
232721010099	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
232721010100	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
232721010101	D-pathway; other site
232721010102	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
232721010103	Cytochrome c; Region: Cytochrom_C; pfam00034
232721010104	Cytochrome c; Region: Cytochrom_C; pfam00034
232721010105	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
232721010106	Peptidase family M50; Region: Peptidase_M50; pfam02163
232721010107	active site
232721010108	putative substrate binding region [chemical binding]; other site
232721010109	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284
232721010110	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
232721010111	active site
232721010112	HIGH motif; other site
232721010113	dimer interface [polypeptide binding]; other site
232721010114	KMSKS motif; other site
232721010115	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
232721010116	Uncharacterized conserved protein [Function unknown]; Region: COG3538
232721010117	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721010118	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721010119	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721010120	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
232721010121	seryl-tRNA synthetase; Provisional; Region: PRK05431
232721010122	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
232721010123	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
232721010124	dimer interface [polypeptide binding]; other site
232721010125	active site
232721010126	motif 1; other site
232721010127	motif 2; other site
232721010128	motif 3; other site
232721010129	FOG: CBS domain [General function prediction only]; Region: COG0517
232721010130	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
232721010131	Domain of unknown function DUF21; Region: DUF21; pfam01595
232721010132	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
232721010133	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
232721010134	Transporter associated domain; Region: CorC_HlyC; smart01091
232721010135	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
232721010136	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
232721010137	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
232721010138	hypothetical protein; Reviewed; Region: PRK00024
232721010139	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
232721010140	MPN+ (JAMM) motif; other site
232721010141	Zinc-binding site [ion binding]; other site
232721010142	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
232721010143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
232721010144	Smr domain; Region: Smr; pfam01713
232721010145	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
232721010146	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
232721010147	active site
232721010148	metal binding site [ion binding]; metal-binding site
232721010149	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
232721010150	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
232721010151	apolar tunnel; other site
232721010152	heme binding site [chemical binding]; other site
232721010153	dimerization interface [polypeptide binding]; other site
232721010154	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
232721010155	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
232721010156	AAA domain; Region: AAA_33; pfam13671
232721010157	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
232721010158	active site
232721010159	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
232721010160	FtsX-like permease family; Region: FtsX; pfam02687
232721010161	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
232721010162	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
232721010163	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
232721010164	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
232721010165	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
232721010166	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
232721010167	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
232721010168	[4Fe-4S] binding site [ion binding]; other site
232721010169	molybdopterin cofactor binding site; other site
232721010170	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
232721010171	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
232721010172	molybdopterin cofactor binding site; other site
232721010173	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
232721010174	4Fe-4S binding domain; Region: Fer4; pfam00037
232721010175	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
232721010176	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
232721010177	4Fe-4S binding domain; Region: Fer4; pfam00037
232721010178	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
232721010179	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
232721010180	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
232721010181	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
232721010182	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
232721010183	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
232721010184	catalytic loop [active]
232721010185	iron binding site [ion binding]; other site
232721010186	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
232721010187	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
232721010188	[4Fe-4S] binding site [ion binding]; other site
232721010189	molybdopterin cofactor binding site; other site
232721010190	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
232721010191	molybdopterin cofactor binding site; other site
232721010192	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
232721010193	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
232721010194	putative dimer interface [polypeptide binding]; other site
232721010195	[2Fe-2S] cluster binding site [ion binding]; other site
232721010196	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
232721010197	SLBB domain; Region: SLBB; pfam10531
232721010198	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
232721010199	lipoprotein signal peptidase; Provisional; Region: PRK14776
232721010200	Heavy-metal-associated domain; Region: HMA; pfam00403
232721010201	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
232721010202	antiporter inner membrane protein; Provisional; Region: PRK11670
232721010203	Domain of unknown function DUF59; Region: DUF59; pfam01883
232721010204	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
232721010205	Walker A motif; other site
232721010206	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
232721010207	gating phenylalanine in ion channel; other site
232721010208	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
232721010209	selenophosphate synthetase; Provisional; Region: PRK00943
232721010210	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
232721010211	dimerization interface [polypeptide binding]; other site
232721010212	putative ATP binding site [chemical binding]; other site
232721010213	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
232721010214	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
232721010215	active site residue [active]
232721010216	Restriction endonuclease; Region: Mrr_cat; pfam04471
232721010217	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
232721010218	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
232721010219	active site
232721010220	HIGH motif; other site
232721010221	KMSKS motif; other site
232721010222	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
232721010223	tRNA binding surface [nucleotide binding]; other site
232721010224	anticodon binding site; other site
232721010225	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
232721010226	dimer interface [polypeptide binding]; other site
232721010227	putative tRNA-binding site [nucleotide binding]; other site
232721010228	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
232721010229	Helix-turn-helix domain; Region: HTH_18; pfam12833
232721010230	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
232721010231	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
232721010232	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
232721010233	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
232721010234	phosphate binding site [ion binding]; other site
232721010235	hypothetical protein; Validated; Region: PRK07586
232721010236	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
232721010237	PYR/PP interface [polypeptide binding]; other site
232721010238	dimer interface [polypeptide binding]; other site
232721010239	TPP binding site [chemical binding]; other site
232721010240	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
232721010241	TPP-binding site [chemical binding]; other site
232721010242	dimer interface [polypeptide binding]; other site
232721010243	Uncharacterized conserved protein [Function unknown]; Region: COG1284
232721010244	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
232721010245	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
232721010246	Domain of unknown function (DUF4309); Region: DUF4309; pfam14172
232721010247	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
232721010248	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
232721010249	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
232721010250	L-aspartate oxidase; Provisional; Region: PRK09077
232721010251	L-aspartate oxidase; Provisional; Region: PRK06175
232721010252	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
232721010253	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
232721010254	tetramerization interface [polypeptide binding]; other site
232721010255	active site
232721010256	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
232721010257	putative substrate binding pocket [chemical binding]; other site
232721010258	trimer interface [polypeptide binding]; other site
232721010259	aminodeoxychorismate synthase; Provisional; Region: PRK07508
232721010260	chorismate binding enzyme; Region: Chorismate_bind; cl10555
232721010261	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
232721010262	substrate-cofactor binding pocket; other site
232721010263	homodimer interface [polypeptide binding]; other site
232721010264	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
232721010265	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721010266	catalytic residue [active]
232721010267	quinolinate synthetase; Provisional; Region: PRK09375
232721010268	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
232721010269	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
232721010270	dimerization interface [polypeptide binding]; other site
232721010271	active site
232721010272	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
232721010273	oligomerization interface [polypeptide binding]; other site
232721010274	active site
232721010275	metal binding site [ion binding]; metal-binding site
232721010276	pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380
232721010277	active site
232721010278	nucleotide binding site [chemical binding]; other site
232721010279	HIGH motif; other site
232721010280	KMSKS motif; other site
232721010281	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
232721010282	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
232721010283	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
232721010284	preprotein translocase subunit SecB; Validated; Region: PRK05751
232721010285	SecA binding site; other site
232721010286	Preprotein binding site; other site
232721010287	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
232721010288	GSH binding site [chemical binding]; other site
232721010289	catalytic residues [active]
232721010290	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
232721010291	active site residue [active]
232721010292	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
232721010293	catalytic core [active]
232721010294	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
232721010295	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
232721010296	C-terminal peptidase (prc); Region: prc; TIGR00225
232721010297	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
232721010298	protein binding site [polypeptide binding]; other site
232721010299	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
232721010300	Catalytic dyad [active]
232721010301	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
232721010302	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
232721010303	ATP binding site [chemical binding]; other site
232721010304	substrate interface [chemical binding]; other site
232721010305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721010306	Response regulator receiver domain; Region: Response_reg; pfam00072
232721010307	active site
232721010308	phosphorylation site [posttranslational modification]
232721010309	intermolecular recognition site; other site
232721010310	dimerization interface [polypeptide binding]; other site
232721010311	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
232721010312	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721010313	active site
232721010314	phosphorylation site [posttranslational modification]
232721010315	intermolecular recognition site; other site
232721010316	dimerization interface [polypeptide binding]; other site
232721010317	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
232721010318	DNA binding residues [nucleotide binding]
232721010319	dimerization interface [polypeptide binding]; other site
232721010320	CHASE3 domain; Region: CHASE3; pfam05227
232721010321	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
232721010322	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721010323	ATP binding site [chemical binding]; other site
232721010324	Mg2+ binding site [ion binding]; other site
232721010325	G-X-G motif; other site
232721010326	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
232721010327	dinuclear metal binding motif [ion binding]; other site
232721010328	BON domain; Region: BON; pfam04972
232721010329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
232721010330	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
232721010331	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
232721010332	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
232721010333	active site
232721010334	(T/H)XGH motif; other site
232721010335	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
232721010336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721010337	S-adenosylmethionine binding site [chemical binding]; other site
232721010338	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
232721010339	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
232721010340	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
232721010341	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
232721010342	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
232721010343	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
232721010344	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
232721010345	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
232721010346	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
232721010347	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
232721010348	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
232721010349	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
232721010350	DNA binding residues [nucleotide binding]
232721010351	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
232721010352	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
232721010353	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
232721010354	ligand binding site [chemical binding]; other site
232721010355	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
232721010356	PAS domain S-box; Region: sensory_box; TIGR00229
232721010357	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721010358	putative active site [active]
232721010359	heme pocket [chemical binding]; other site
232721010360	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721010361	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721010362	metal binding site [ion binding]; metal-binding site
232721010363	active site
232721010364	I-site; other site
232721010365	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
232721010366	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
232721010367	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
232721010368	Cu(I) binding site [ion binding]; other site
232721010369	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
232721010370	UbiA prenyltransferase family; Region: UbiA; pfam01040
232721010371	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
232721010372	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
232721010373	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
232721010374	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
232721010375	Subunit III/VIIa interface [polypeptide binding]; other site
232721010376	Phospholipid binding site [chemical binding]; other site
232721010377	Subunit I/III interface [polypeptide binding]; other site
232721010378	Subunit III/VIb interface [polypeptide binding]; other site
232721010379	Subunit III/VIa interface; other site
232721010380	Subunit III/Vb interface [polypeptide binding]; other site
232721010381	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
232721010382	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
232721010383	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
232721010384	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
232721010385	Subunit I/III interface [polypeptide binding]; other site
232721010386	D-pathway; other site
232721010387	Subunit I/VIIc interface [polypeptide binding]; other site
232721010388	Subunit I/IV interface [polypeptide binding]; other site
232721010389	Subunit I/II interface [polypeptide binding]; other site
232721010390	Low-spin heme (heme a) binding site [chemical binding]; other site
232721010391	Subunit I/VIIa interface [polypeptide binding]; other site
232721010392	Subunit I/VIa interface [polypeptide binding]; other site
232721010393	Dimer interface; other site
232721010394	Putative water exit pathway; other site
232721010395	Binuclear center (heme a3/CuB) [ion binding]; other site
232721010396	K-pathway; other site
232721010397	Subunit I/Vb interface [polypeptide binding]; other site
232721010398	Putative proton exit pathway; other site
232721010399	Subunit I/VIb interface; other site
232721010400	Subunit I/VIc interface [polypeptide binding]; other site
232721010401	Electron transfer pathway; other site
232721010402	Subunit I/VIIIb interface [polypeptide binding]; other site
232721010403	Subunit I/VIIb interface [polypeptide binding]; other site
232721010404	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
232721010405	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
232721010406	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
232721010407	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
232721010408	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
232721010409	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
232721010410	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
232721010411	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
232721010412	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
232721010413	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
232721010414	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
232721010415	putative active site [active]
232721010416	putative catalytic site [active]
232721010417	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
232721010418	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
232721010419	P-loop; other site
232721010420	Magnesium ion binding site [ion binding]; other site
232721010421	LysE type translocator; Region: LysE; cl00565
232721010422	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
232721010423	TrkA-N domain; Region: TrkA_N; pfam02254
232721010424	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721010425	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
232721010426	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
232721010427	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721010428	dimer interface [polypeptide binding]; other site
232721010429	active site
232721010430	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
232721010431	Coenzyme A transferase; Region: CoA_trans; cl17247
232721010432	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
232721010433	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
232721010434	Bacterial transcriptional regulator; Region: IclR; pfam01614
232721010435	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
232721010436	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
232721010437	Ligand Binding Site [chemical binding]; other site
232721010438	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
232721010439	Ligand Binding Site [chemical binding]; other site
232721010440	Cytochrome c553 [Energy production and conversion]; Region: COG2863
232721010441	Cytochrome c; Region: Cytochrom_C; cl11414
232721010442	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721010443	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
232721010444	Walker A motif; other site
232721010445	ATP binding site [chemical binding]; other site
232721010446	Walker B motif; other site
232721010447	arginine finger; other site
232721010448	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
232721010449	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
232721010450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
232721010451	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
232721010452	Surface antigen; Region: Bac_surface_Ag; pfam01103
232721010453	Family of unknown function (DUF490); Region: DUF490; pfam04357
232721010454	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
232721010455	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
232721010456	putative active site [active]
232721010457	catalytic site [active]
232721010458	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
232721010459	putative active site [active]
232721010460	catalytic site [active]
232721010461	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
232721010462	ArsC family; Region: ArsC; pfam03960
232721010463	catalytic residues [active]
232721010464	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
232721010465	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
232721010466	dimer interface [polypeptide binding]; other site
232721010467	conserved gate region; other site
232721010468	putative PBP binding loops; other site
232721010469	ABC-ATPase subunit interface; other site
232721010470	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
232721010471	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
232721010472	Walker A/P-loop; other site
232721010473	ATP binding site [chemical binding]; other site
232721010474	Q-loop/lid; other site
232721010475	ABC transporter signature motif; other site
232721010476	Walker B; other site
232721010477	D-loop; other site
232721010478	H-loop/switch region; other site
232721010479	TOBE domain; Region: TOBE_2; pfam08402
232721010480	Yip1 domain; Region: Yip1; pfam04893
232721010481	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
232721010482	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
232721010483	putative acyl-acceptor binding pocket; other site
232721010484	dihydroorotase; Provisional; Region: PRK07627
232721010485	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
232721010486	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
232721010487	active site
232721010488	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
232721010489	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
232721010490	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
232721010491	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
232721010492	active site
232721010493	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
232721010494	hypothetical protein; Validated; Region: PRK00228
232721010495	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
232721010496	putative binding surface; other site
232721010497	active site
232721010498	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
232721010499	putative binding surface; other site
232721010500	active site
232721010501	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
232721010502	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
232721010503	putative binding surface; other site
232721010504	active site
232721010505	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
232721010506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721010507	ATP binding site [chemical binding]; other site
232721010508	Mg2+ binding site [ion binding]; other site
232721010509	G-X-G motif; other site
232721010510	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
232721010511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721010512	Response regulator receiver domain; Region: Response_reg; pfam00072
232721010513	active site
232721010514	phosphorylation site [posttranslational modification]
232721010515	intermolecular recognition site; other site
232721010516	dimerization interface [polypeptide binding]; other site
232721010517	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
232721010518	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721010519	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721010520	dimer interface [polypeptide binding]; other site
232721010521	putative CheW interface [polypeptide binding]; other site
232721010522	CheW-like domain; Region: CheW; pfam01584
232721010523	Response regulator receiver domain; Region: Response_reg; pfam00072
232721010524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721010525	active site
232721010526	phosphorylation site [posttranslational modification]
232721010527	intermolecular recognition site; other site
232721010528	dimerization interface [polypeptide binding]; other site
232721010529	Response regulator receiver domain; Region: Response_reg; pfam00072
232721010530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721010531	active site
232721010532	phosphorylation site [posttranslational modification]
232721010533	intermolecular recognition site; other site
232721010534	dimerization interface [polypeptide binding]; other site
232721010535	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
232721010536	Rubredoxin; Region: Rubredoxin; pfam00301
232721010537	iron binding site [ion binding]; other site
232721010538	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
232721010539	substrate binding site [chemical binding]; other site
232721010540	ATP binding site [chemical binding]; other site
232721010541	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
232721010542	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
232721010543	inhibitor-cofactor binding pocket; inhibition site
232721010544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721010545	catalytic residue [active]
232721010546	PhoD-like phosphatase; Region: PhoD; pfam09423
232721010547	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
232721010548	putative active site [active]
232721010549	putative metal binding site [ion binding]; other site
232721010550	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
232721010551	Cytochrome c; Region: Cytochrom_C; cl11414
232721010552	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
232721010553	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
232721010554	purine monophosphate binding site [chemical binding]; other site
232721010555	dimer interface [polypeptide binding]; other site
232721010556	putative catalytic residues [active]
232721010557	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
232721010558	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
232721010559	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
232721010560	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
232721010561	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
232721010562	FMN binding site [chemical binding]; other site
232721010563	active site
232721010564	catalytic residues [active]
232721010565	substrate binding site [chemical binding]; other site
232721010566	Predicted membrane protein [Function unknown]; Region: COG1238
232721010567	HipA N-terminal domain; Region: Couple_hipA; pfam13657
232721010568	HipA-like N-terminal domain; Region: HipA_N; pfam07805
232721010569	HipA-like C-terminal domain; Region: HipA_C; pfam07804
232721010570	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721010571	non-specific DNA binding site [nucleotide binding]; other site
232721010572	salt bridge; other site
232721010573	sequence-specific DNA binding site [nucleotide binding]; other site
232721010574	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
232721010575	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721010576	non-specific DNA binding site [nucleotide binding]; other site
232721010577	salt bridge; other site
232721010578	sequence-specific DNA binding site [nucleotide binding]; other site
232721010579	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
232721010580	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
232721010581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721010582	Walker A motif; other site
232721010583	ATP binding site [chemical binding]; other site
232721010584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721010585	Integrase core domain; Region: rve; pfam00665
232721010586	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
232721010587	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
232721010588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721010589	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
232721010590	Walker A motif; other site
232721010591	ATP binding site [chemical binding]; other site
232721010592	Walker B motif; other site
232721010593	Protein of unknown function DUF262; Region: DUF262; pfam03235
232721010594	Uncharacterized conserved protein [Function unknown]; Region: COG1479
232721010595	Uncharacterized conserved protein [Function unknown]; Region: COG3472
232721010596	Divergent AAA domain; Region: AAA_4; pfam04326
232721010597	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
232721010598	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
232721010599	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
232721010600	active site
232721010601	AAA domain; Region: AAA_21; pfam13304
232721010602	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721010603	Q-loop/lid; other site
232721010604	ABC transporter signature motif; other site
232721010605	Walker B; other site
232721010606	D-loop; other site
232721010607	H-loop/switch region; other site
232721010608	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
232721010609	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
232721010610	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721010611	ATP binding site [chemical binding]; other site
232721010612	putative Mg++ binding site [ion binding]; other site
232721010613	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
232721010614	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
232721010615	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
232721010616	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
232721010617	Divergent AAA domain; Region: AAA_4; pfam04326
232721010618	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
232721010619	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
232721010620	HsdM N-terminal domain; Region: HsdM_N; pfam12161
232721010621	Methyltransferase domain; Region: Methyltransf_26; pfam13659
232721010622	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
232721010623	HsdM N-terminal domain; Region: HsdM_N; pfam12161
232721010624	Methyltransferase domain; Region: Methyltransf_26; pfam13659
232721010625	Transposase domain (DUF772); Region: DUF772; pfam05598
232721010626	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721010627	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721010628	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
232721010629	active site
232721010630	catalytic residues [active]
232721010631	DNA binding site [nucleotide binding]
232721010632	Int/Topo IB signature motif; other site
232721010633	integrase; Provisional; Region: PRK09692
232721010634	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
232721010635	active site
232721010636	Int/Topo IB signature motif; other site
232721010637	GTP-binding protein YchF; Reviewed; Region: PRK09601
232721010638	YchF GTPase; Region: YchF; cd01900
232721010639	G1 box; other site
232721010640	GTP/Mg2+ binding site [chemical binding]; other site
232721010641	Switch I region; other site
232721010642	G2 box; other site
232721010643	Switch II region; other site
232721010644	G3 box; other site
232721010645	G4 box; other site
232721010646	G5 box; other site
232721010647	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
232721010648	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
232721010649	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
232721010650	MOSC domain; Region: MOSC; pfam03473
232721010651	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
232721010652	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
232721010653	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
232721010654	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
232721010655	dimerization domain [polypeptide binding]; other site
232721010656	dimer interface [polypeptide binding]; other site
232721010657	catalytic residues [active]
232721010658	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
232721010659	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
232721010660	enoyl-CoA hydratase; Provisional; Region: PRK05862
232721010661	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721010662	substrate binding site [chemical binding]; other site
232721010663	oxyanion hole (OAH) forming residues; other site
232721010664	trimer interface [polypeptide binding]; other site
232721010665	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
232721010666	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
232721010667	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
232721010668	FeS/SAM binding site; other site
232721010669	TRAM domain; Region: TRAM; pfam01938
232721010670	signal recognition particle protein; Provisional; Region: PRK10867
232721010671	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
232721010672	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
232721010673	GTP binding site [chemical binding]; other site
232721010674	Signal peptide binding domain; Region: SRP_SPB; pfam02978
232721010675	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
232721010676	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
232721010677	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
232721010678	putative active site [active]
232721010679	heme pocket [chemical binding]; other site
232721010680	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721010681	dimer interface [polypeptide binding]; other site
232721010682	phosphorylation site [posttranslational modification]
232721010683	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721010684	ATP binding site [chemical binding]; other site
232721010685	Mg2+ binding site [ion binding]; other site
232721010686	G-X-G motif; other site
232721010687	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
232721010688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721010689	active site
232721010690	phosphorylation site [posttranslational modification]
232721010691	intermolecular recognition site; other site
232721010692	dimerization interface [polypeptide binding]; other site
232721010693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721010694	Walker A motif; other site
232721010695	ATP binding site [chemical binding]; other site
232721010696	Walker B motif; other site
232721010697	arginine finger; other site
232721010698	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
232721010699	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
232721010700	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
232721010701	amidase catalytic site [active]
232721010702	Zn binding residues [ion binding]; other site
232721010703	substrate binding site [chemical binding]; other site
232721010704	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
232721010705	ATP cone domain; Region: ATP-cone; pfam03477
232721010706	Class I ribonucleotide reductase; Region: RNR_I; cd01679
232721010707	active site
232721010708	dimer interface [polypeptide binding]; other site
232721010709	catalytic residues [active]
232721010710	effector binding site; other site
232721010711	R2 peptide binding site; other site
232721010712	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
232721010713	dimer interface [polypeptide binding]; other site
232721010714	putative radical transfer pathway; other site
232721010715	diiron center [ion binding]; other site
232721010716	tyrosyl radical; other site
232721010717	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
232721010718	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
232721010719	substrate binding site [chemical binding]; other site
232721010720	ATP binding site [chemical binding]; other site
232721010721	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
232721010722	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
232721010723	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
232721010724	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
232721010725	S-adenosylmethionine binding site [chemical binding]; other site
232721010726	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
232721010727	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
232721010728	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
232721010729	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
232721010730	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
232721010731	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
232721010732	carboxyltransferase (CT) interaction site; other site
232721010733	biotinylation site [posttranslational modification]; other site
232721010734	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
232721010735	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
232721010736	catalytic residues [active]
232721010737	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
232721010738	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
232721010739	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
232721010740	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
232721010741	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
232721010742	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
232721010743	protease TldD; Provisional; Region: tldD; PRK10735
232721010744	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
232721010745	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
232721010746	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
232721010747	O-Antigen ligase; Region: Wzy_C; pfam04932
232721010748	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
232721010749	Cytochrome c2 [Energy production and conversion]; Region: COG3474
232721010750	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
232721010751	dinuclear metal binding motif [ion binding]; other site
232721010752	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
232721010753	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
232721010754	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
232721010755	DNA binding residues [nucleotide binding]
232721010756	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
232721010757	RNB domain; Region: RNB; pfam00773
232721010758	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
232721010759	Gram-negative bacterial tonB protein; Region: TonB; cl10048
232721010760	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
232721010761	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
232721010762	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
232721010763	shikimate binding site; other site
232721010764	NAD(P) binding site [chemical binding]; other site
232721010765	Transglycosylase; Region: Transgly; cl17702
232721010766	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
232721010767	active site
232721010768	putative DNA-binding cleft [nucleotide binding]; other site
232721010769	dimer interface [polypeptide binding]; other site
232721010770	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
232721010771	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721010772	dimerization interface [polypeptide binding]; other site
232721010773	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721010774	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721010775	dimer interface [polypeptide binding]; other site
232721010776	putative CheW interface [polypeptide binding]; other site
232721010777	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
232721010778	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
232721010779	dimerization interface [polypeptide binding]; other site
232721010780	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721010781	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721010782	dimer interface [polypeptide binding]; other site
232721010783	putative CheW interface [polypeptide binding]; other site
232721010784	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
232721010785	ThiC-associated domain; Region: ThiC-associated; pfam13667
232721010786	ThiC family; Region: ThiC; pfam01964
232721010787	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
232721010788	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
232721010789	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
232721010790	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721010791	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721010792	dimer interface [polypeptide binding]; other site
232721010793	putative CheW interface [polypeptide binding]; other site
232721010794	cell division protein FtsZ; Validated; Region: PRK09330
232721010795	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
232721010796	nucleotide binding site [chemical binding]; other site
232721010797	SulA interaction site; other site
232721010798	cell division protein FtsA; Region: ftsA; TIGR01174
232721010799	Cell division protein FtsA; Region: FtsA; smart00842
232721010800	Cell division protein FtsA; Region: FtsA; pfam14450
232721010801	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
232721010802	Cell division protein FtsQ; Region: FtsQ; pfam03799
232721010803	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
232721010804	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
232721010805	ATP-grasp domain; Region: ATP-grasp_4; cl17255
232721010806	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
232721010807	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
232721010808	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
232721010809	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
232721010810	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
232721010811	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
232721010812	active site
232721010813	homodimer interface [polypeptide binding]; other site
232721010814	cell division protein FtsW; Region: ftsW; TIGR02614
232721010815	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
232721010816	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
232721010817	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
232721010818	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
232721010819	Mg++ binding site [ion binding]; other site
232721010820	putative catalytic motif [active]
232721010821	putative substrate binding site [chemical binding]; other site
232721010822	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
232721010823	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
232721010824	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
232721010825	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
232721010826	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
232721010827	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
232721010828	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
232721010829	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
232721010830	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
232721010831	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
232721010832	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
232721010833	Cell division protein FtsL; Region: FtsL; pfam04999
232721010834	MraW methylase family; Region: Methyltransf_5; cl17771
232721010835	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
232721010836	cell division protein MraZ; Reviewed; Region: PRK00326
232721010837	MraZ protein; Region: MraZ; pfam02381
232721010838	MraZ protein; Region: MraZ; pfam02381
232721010839	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
232721010840	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721010841	Walker A motif; other site
232721010842	ATP binding site [chemical binding]; other site
232721010843	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
232721010844	Walker B motif; other site
232721010845	arginine finger; other site
232721010846	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
232721010847	ATP-dependent protease subunit HslV; Provisional; Region: PRK05456
232721010848	active site
232721010849	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
232721010850	STAS domain; Region: STAS_2; pfam13466
232721010851	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
232721010852	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
232721010853	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
232721010854	P-loop, Walker A motif; other site
232721010855	Base recognition motif; other site
232721010856	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
232721010857	PUA domain; Region: PUA; cl00607
232721010858	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
232721010859	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
232721010860	putative RNA binding site [nucleotide binding]; other site
232721010861	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721010862	S-adenosylmethionine binding site [chemical binding]; other site
232721010863	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
232721010864	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
232721010865	active site
232721010866	DNA binding site [nucleotide binding]
232721010867	Int/Topo IB signature motif; other site
232721010868	Protein of unknown function, DUF484; Region: DUF484; cl17449
232721010869	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
232721010870	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
232721010871	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
232721010872	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
232721010873	nudix motif; other site
232721010874	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
232721010875	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
232721010876	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
232721010877	RNA binding surface [nucleotide binding]; other site
232721010878	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
232721010879	active site
232721010880	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
232721010881	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
232721010882	YhhN-like protein; Region: YhhN; pfam07947
232721010883	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
232721010884	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721010885	Walker A motif; other site
232721010886	ATP binding site [chemical binding]; other site
232721010887	Walker B motif; other site
232721010888	arginine finger; other site
232721010889	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
232721010890	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
232721010891	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
232721010892	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
232721010893	nucleotide binding site [chemical binding]; other site
232721010894	putative NEF/HSP70 interaction site [polypeptide binding]; other site
232721010895	SBD interface [polypeptide binding]; other site
232721010896	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
232721010897	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
232721010898	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
232721010899	nucleotide binding site [chemical binding]; other site
232721010900	putative NEF/HSP70 interaction site [polypeptide binding]; other site
232721010901	SBD interface [polypeptide binding]; other site
232721010902	DNA-K related protein; Region: DUF3731; pfam12531
232721010903	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
232721010904	RuvA N terminal domain; Region: RuvA_N; pfam01330
232721010905	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
232721010906	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
232721010907	PhoH-like protein; Region: PhoH; pfam02562
232721010908	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
232721010909	Transposase domain (DUF772); Region: DUF772; pfam05598
232721010910	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721010911	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721010912	hypothetical protein; Provisional; Region: PRK10621
232721010913	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
232721010914	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
232721010915	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
232721010916	ATP binding site [chemical binding]; other site
232721010917	Mg++ binding site [ion binding]; other site
232721010918	motif III; other site
232721010919	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
232721010920	nucleotide binding region [chemical binding]; other site
232721010921	ATP-binding site [chemical binding]; other site
232721010922	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
232721010923	putative RNA binding site [nucleotide binding]; other site
232721010924	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
232721010925	putative active site [active]
232721010926	dimerization interface [polypeptide binding]; other site
232721010927	putative tRNAtyr binding site [nucleotide binding]; other site
232721010928	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
232721010929	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
232721010930	PAS fold; Region: PAS_4; pfam08448
232721010931	PAS domain S-box; Region: sensory_box; TIGR00229
232721010932	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721010933	putative active site [active]
232721010934	heme pocket [chemical binding]; other site
232721010935	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721010936	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721010937	metal binding site [ion binding]; metal-binding site
232721010938	active site
232721010939	I-site; other site
232721010940	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
232721010941	AMP nucleosidase; Provisional; Region: PRK08292
232721010942	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
232721010943	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
232721010944	MgtC family; Region: MgtC; pfam02308
232721010945	Predicted membrane protein [Function unknown]; Region: COG3174
232721010946	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
232721010947	nodulation ABC transporter NodI; Provisional; Region: PRK13537
232721010948	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
232721010949	Walker A/P-loop; other site
232721010950	ATP binding site [chemical binding]; other site
232721010951	Q-loop/lid; other site
232721010952	ABC transporter signature motif; other site
232721010953	Walker B; other site
232721010954	D-loop; other site
232721010955	H-loop/switch region; other site
232721010956	ABC-2 type transporter; Region: ABC2_membrane; cl17235
232721010957	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
232721010958	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
232721010959	GAF domain; Region: GAF; pfam01590
232721010960	Hemerythrin-like domain of FBXL5-like proteins; Region: Hr_FBXL5; cd12109
232721010961	Fe binding site [ion binding]; other site
232721010962	choline dehydrogenase; Validated; Region: PRK02106
232721010963	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
232721010964	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
232721010965	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
232721010966	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
232721010967	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
232721010968	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
232721010969	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
232721010970	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
232721010971	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
232721010972	dimer interface [polypeptide binding]; other site
232721010973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721010974	catalytic residue [active]
232721010975	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
232721010976	putative catalytic site [active]
232721010977	putative metal binding site [ion binding]; other site
232721010978	putative phosphate binding site [ion binding]; other site
232721010979	cardiolipin synthase 2; Provisional; Region: PRK11263
232721010980	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
232721010981	putative active site [active]
232721010982	catalytic site [active]
232721010983	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
232721010984	putative active site [active]
232721010985	catalytic site [active]
232721010986	Predicted integral membrane protein [Function unknown]; Region: COG0392
232721010987	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
232721010988	Predicted membrane protein [Function unknown]; Region: COG2860
232721010989	UPF0126 domain; Region: UPF0126; pfam03458
232721010990	UPF0126 domain; Region: UPF0126; pfam03458
232721010991	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
232721010992	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
232721010993	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
232721010994	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
232721010995	Ligand binding site [chemical binding]; other site
232721010996	Electron transfer flavoprotein domain; Region: ETF; pfam01012
232721010997	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
232721010998	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
232721010999	FMN binding site [chemical binding]; other site
232721011000	substrate binding site [chemical binding]; other site
232721011001	putative catalytic residue [active]
232721011002	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721011003	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
232721011004	CoA-transferase family III; Region: CoA_transf_3; pfam02515
232721011005	enoyl-CoA hydratase; Provisional; Region: PRK07511
232721011006	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721011007	substrate binding site [chemical binding]; other site
232721011008	oxyanion hole (OAH) forming residues; other site
232721011009	trimer interface [polypeptide binding]; other site
232721011010	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
232721011011	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
232721011012	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
232721011013	active site
232721011014	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
232721011015	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721011016	active site
232721011017	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
232721011018	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721011019	dimer interface [polypeptide binding]; other site
232721011020	active site
232721011021	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721011022	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
232721011023	substrate binding site [chemical binding]; other site
232721011024	oxyanion hole (OAH) forming residues; other site
232721011025	trimer interface [polypeptide binding]; other site
232721011026	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
232721011027	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
232721011028	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
232721011029	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721011030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721011031	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
232721011032	putative effector binding pocket; other site
232721011033	dimerization interface [polypeptide binding]; other site
232721011034	heat shock protein HtpX; Provisional; Region: PRK05457
232721011035	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
232721011036	Uncharacterized conserved protein [Function unknown]; Region: COG1432
232721011037	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
232721011038	putative metal binding site [ion binding]; other site
232721011039	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
232721011040	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
232721011041	active site
232721011042	substrate binding pocket [chemical binding]; other site
232721011043	dimer interface [polypeptide binding]; other site
232721011044	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
232721011045	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
232721011046	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
232721011047	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
232721011048	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721011049	Walker A/P-loop; other site
232721011050	ATP binding site [chemical binding]; other site
232721011051	Q-loop/lid; other site
232721011052	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
232721011053	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
232721011054	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
232721011055	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
232721011056	putative ligand binding site [chemical binding]; other site
232721011057	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
232721011058	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
232721011059	putative ligand binding site [chemical binding]; other site
232721011060	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
232721011061	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
232721011062	trimer interface [polypeptide binding]; other site
232721011063	eyelet of channel; other site
232721011064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721011065	putative substrate translocation pore; other site
232721011066	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
232721011067	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
232721011068	putative catalytic residue [active]
232721011069	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
232721011070	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
232721011071	putative deacylase active site [active]
232721011072	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
232721011073	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
232721011074	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721011075	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721011076	metal binding site [ion binding]; metal-binding site
232721011077	active site
232721011078	I-site; other site
232721011079	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
232721011080	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
232721011081	active site
232721011082	catalytic residues [active]
232721011083	metal binding site [ion binding]; metal-binding site
232721011084	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
232721011085	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
232721011086	putative ligand binding site [chemical binding]; other site
232721011087	NAD binding site [chemical binding]; other site
232721011088	dimerization interface [polypeptide binding]; other site
232721011089	catalytic site [active]
232721011090	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
232721011091	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
232721011092	ATP-grasp domain; Region: ATP-grasp_4; cl17255
232721011093	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
232721011094	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
232721011095	carboxyltransferase (CT) interaction site; other site
232721011096	biotinylation site [posttranslational modification]; other site
232721011097	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
232721011098	enoyl-CoA hydratase; Provisional; Region: PRK05995
232721011099	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
232721011100	substrate binding site [chemical binding]; other site
232721011101	oxyanion hole (OAH) forming residues; other site
232721011102	trimer interface [polypeptide binding]; other site
232721011103	DinB family; Region: DinB; cl17821
232721011104	DinB superfamily; Region: DinB_2; pfam12867
232721011105	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
232721011106	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
232721011107	AMP-binding domain protein; Validated; Region: PRK08315
232721011108	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
232721011109	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
232721011110	acyl-activating enzyme (AAE) consensus motif; other site
232721011111	putative AMP binding site [chemical binding]; other site
232721011112	putative active site [active]
232721011113	putative CoA binding site [chemical binding]; other site
232721011114	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
232721011115	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
232721011116	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
232721011117	Transposase domain (DUF772); Region: DUF772; pfam05598
232721011118	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
232721011119	DDE superfamily endonuclease; Region: DDE_4; cl17710
232721011120	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
232721011121	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
232721011122	putative C-terminal domain interface [polypeptide binding]; other site
232721011123	putative GSH binding site (G-site) [chemical binding]; other site
232721011124	putative dimer interface [polypeptide binding]; other site
232721011125	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
232721011126	N-terminal domain interface [polypeptide binding]; other site
232721011127	dimer interface [polypeptide binding]; other site
232721011128	substrate binding pocket (H-site) [chemical binding]; other site
232721011129	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
232721011130	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
232721011131	acyl-activating enzyme (AAE) consensus motif; other site
232721011132	putative AMP binding site [chemical binding]; other site
232721011133	putative active site [active]
232721011134	putative CoA binding site [chemical binding]; other site
232721011135	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
232721011136	hypothetical protein; Provisional; Region: PRK01842
232721011137	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
232721011138	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721011139	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721011140	dimer interface [polypeptide binding]; other site
232721011141	putative CheW interface [polypeptide binding]; other site
232721011142	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
232721011143	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721011144	motif II; other site
232721011145	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
232721011146	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
232721011147	active site
232721011148	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
232721011149	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
232721011150	NADP binding site [chemical binding]; other site
232721011151	homodimer interface [polypeptide binding]; other site
232721011152	active site
232721011153	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
232721011154	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
232721011155	dimer interface [polypeptide binding]; other site
232721011156	active site
232721011157	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
232721011158	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
232721011159	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
232721011160	active site clefts [active]
232721011161	zinc binding site [ion binding]; other site
232721011162	dimer interface [polypeptide binding]; other site
232721011163	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
232721011164	isovaleryl-CoA dehydrogenase; Region: PLN02519
232721011165	substrate binding site [chemical binding]; other site
232721011166	FAD binding site [chemical binding]; other site
232721011167	catalytic base [active]
232721011168	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
232721011169	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
232721011170	DNA binding residues [nucleotide binding]
232721011171	putative dimer interface [polypeptide binding]; other site
232721011172	Transposase, Mutator family; Region: Transposase_mut; pfam00872
232721011173	MULE transposase domain; Region: MULE; pfam10551
232721011174	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
232721011175	Integrase core domain; Region: rve; pfam00665
232721011176	Integrase core domain; Region: rve_3; pfam13683
232721011177	ABC transporter ATPase component; Reviewed; Region: PRK11147
232721011178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721011179	Walker A/P-loop; other site
232721011180	ATP binding site [chemical binding]; other site
232721011181	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
232721011182	ABC transporter signature motif; other site
232721011183	Walker B; other site
232721011184	ABC transporter; Region: ABC_tran_2; pfam12848
232721011185	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
232721011186	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
232721011187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721011188	active site
232721011189	phosphorylation site [posttranslational modification]
232721011190	intermolecular recognition site; other site
232721011191	dimerization interface [polypeptide binding]; other site
232721011192	CheB methylesterase; Region: CheB_methylest; pfam01339
232721011193	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13487
232721011194	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
232721011195	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
232721011196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721011197	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
232721011198	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
232721011199	putative binding surface; other site
232721011200	active site
232721011201	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
232721011202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721011203	ATP binding site [chemical binding]; other site
232721011204	Mg2+ binding site [ion binding]; other site
232721011205	G-X-G motif; other site
232721011206	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
232721011207	Response regulator receiver domain; Region: Response_reg; pfam00072
232721011208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721011209	active site
232721011210	phosphorylation site [posttranslational modification]
232721011211	intermolecular recognition site; other site
232721011212	dimerization interface [polypeptide binding]; other site
232721011213	Response regulator receiver domain; Region: Response_reg; pfam00072
232721011214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721011215	active site
232721011216	phosphorylation site [posttranslational modification]
232721011217	intermolecular recognition site; other site
232721011218	dimerization interface [polypeptide binding]; other site
232721011219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
232721011220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721011221	ATP binding site [chemical binding]; other site
232721011222	Mg2+ binding site [ion binding]; other site
232721011223	G-X-G motif; other site
232721011224	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
232721011225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721011226	active site
232721011227	phosphorylation site [posttranslational modification]
232721011228	intermolecular recognition site; other site
232721011229	dimerization interface [polypeptide binding]; other site
232721011230	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
232721011231	DNA binding residues [nucleotide binding]
232721011232	dimerization interface [polypeptide binding]; other site
232721011233	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
232721011234	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
232721011235	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
232721011236	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
232721011237	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
232721011238	flagellar motor switch protein; Validated; Region: fliN; PRK05698
232721011239	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
232721011240	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
232721011241	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
232721011242	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
232721011243	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
232721011244	Flagellar FliJ protein; Region: FliJ; pfam02050
232721011245	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
232721011246	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
232721011247	Walker A motif/ATP binding site; other site
232721011248	Walker B motif; other site
232721011249	Flagellar assembly protein FliH; Region: FliH; pfam02108
232721011250	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
232721011251	FliG C-terminal domain; Region: FliG_C; pfam01706
232721011252	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
232721011253	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
232721011254	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
232721011255	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
232721011256	Flagellar protein FliT; Region: FliT; pfam05400
232721011257	Flagellar protein FliS; Region: FliS; cl00654
232721011258	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
232721011259	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
232721011260	flagellin; Provisional; Region: PRK12802
232721011261	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
232721011262	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
232721011263	flagellin; Provisional; Region: PRK12802
232721011264	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
232721011265	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
232721011266	flagellin; Provisional; Region: PRK12802
232721011267	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
232721011268	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
232721011269	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
232721011270	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
232721011271	flagellar motor protein MotB; Validated; Region: motB; PRK09041
232721011272	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
232721011273	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
232721011274	ligand binding site [chemical binding]; other site
232721011275	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
232721011276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721011277	active site
232721011278	phosphorylation site [posttranslational modification]
232721011279	intermolecular recognition site; other site
232721011280	dimerization interface [polypeptide binding]; other site
232721011281	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
232721011282	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
232721011283	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
232721011284	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
232721011285	FHIPEP family; Region: FHIPEP; pfam00771
232721011286	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
232721011287	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
232721011288	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
232721011289	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
232721011290	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
232721011291	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
232721011292	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
232721011293	DNA binding residues [nucleotide binding]
232721011294	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
232721011295	SAF-like; Region: SAF_2; pfam13144
232721011296	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
232721011297	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
232721011298	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
232721011299	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
232721011300	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
232721011301	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
232721011302	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
232721011303	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
232721011304	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
232721011305	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
232721011306	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
232721011307	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
232721011308	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
232721011309	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
232721011310	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
232721011311	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
232721011312	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
232721011313	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
232721011314	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
232721011315	Flagellar L-ring protein; Region: FlgH; pfam02107
232721011316	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
232721011317	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
232721011318	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
232721011319	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
232721011320	Rod binding protein; Region: Rod-binding; cl01626
232721011321	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
232721011322	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
232721011323	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
232721011324	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
232721011325	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
232721011326	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
232721011327	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
232721011328	Na2 binding site [ion binding]; other site
232721011329	putative substrate binding site 1 [chemical binding]; other site
232721011330	Na binding site 1 [ion binding]; other site
232721011331	putative substrate binding site 2 [chemical binding]; other site
232721011332	Nitronate monooxygenase; Region: NMO; pfam03060
232721011333	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
232721011334	FMN binding site [chemical binding]; other site
232721011335	substrate binding site [chemical binding]; other site
232721011336	putative catalytic residue [active]
232721011337	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
232721011338	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
232721011339	DNA-binding site [nucleotide binding]; DNA binding site
232721011340	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721011341	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721011342	homodimer interface [polypeptide binding]; other site
232721011343	catalytic residue [active]
232721011344	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
232721011345	EamA-like transporter family; Region: EamA; pfam00892
232721011346	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
232721011347	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
232721011348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721011349	homodimer interface [polypeptide binding]; other site
232721011350	catalytic residue [active]
232721011351	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
232721011352	Src homology 2 (SH2) domain; Region: SH2; cl15255
232721011353	phosphotyrosine binding pocket [polypeptide binding]; other site
232721011354	hydrophobic binding pocket [polypeptide binding]; other site
232721011355	hypothetical protein; Provisional; Region: PRK06110
232721011356	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
232721011357	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721011358	catalytic residue [active]
232721011359	Putative cyclase; Region: Cyclase; cl00814
232721011360	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
232721011361	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
232721011362	putative ligand binding site [chemical binding]; other site
232721011363	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
232721011364	NAD(P) binding site [chemical binding]; other site
232721011365	active site
232721011366	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
232721011367	catalytic core [active]
232721011368	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
232721011369	Creatinine amidohydrolase; Region: Creatininase; pfam02633
232721011370	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
232721011371	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
232721011372	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
232721011373	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
232721011374	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
232721011375	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
232721011376	DsbD alpha interface [polypeptide binding]; other site
232721011377	catalytic residues [active]
232721011378	Uncharacterized conserved protein [Function unknown]; Region: COG1262
232721011379	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
232721011380	Na+/H+ antiporter [Inorganic ion transport and metabolism]; Region: NhaA; COG3004
232721011381	CoA binding domain; Region: CoA_binding; cl17356
232721011382	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
232721011383	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
232721011384	homodimer interface [polypeptide binding]; other site
232721011385	substrate-cofactor binding pocket; other site
232721011386	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721011387	catalytic residue [active]
232721011388	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
232721011389	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
232721011390	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721011391	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721011392	dimerization interface [polypeptide binding]; other site
232721011393	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
232721011394	substrate binding site [chemical binding]; other site
232721011395	active site
232721011396	primosome assembly protein PriA; Validated; Region: PRK05580
232721011397	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
232721011398	ATP binding site [chemical binding]; other site
232721011399	putative Mg++ binding site [ion binding]; other site
232721011400	helicase superfamily c-terminal domain; Region: HELICc; smart00490
232721011401	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
232721011402	active site
232721011403	homodimer interface [polypeptide binding]; other site
232721011404	Predicted permeases [General function prediction only]; Region: COG0679
232721011405	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
232721011406	Part of AAA domain; Region: AAA_19; pfam13245
232721011407	Family description; Region: UvrD_C_2; pfam13538
232721011408	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
232721011409	substrate binding site [chemical binding]; other site
232721011410	dimerization interface [polypeptide binding]; other site
232721011411	active site
232721011412	calcium binding site [ion binding]; other site
232721011413	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
232721011414	Ligand Binding Site [chemical binding]; other site
232721011415	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
232721011416	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
232721011417	Protein of unknown function DUF72; Region: DUF72; pfam01904
232721011418	Putative zinc ribbon domain; Region: DUF164; pfam02591
232721011419	Double zinc ribbon; Region: DZR; pfam12773
232721011420	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
232721011421	yiaA/B two helix domain; Region: YiaAB; cl01759
232721011422	yiaA/B two helix domain; Region: YiaAB; cl01759
232721011423	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721011424	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721011425	putative DNA binding site [nucleotide binding]; other site
232721011426	putative Zn2+ binding site [ion binding]; other site
232721011427	AsnC family; Region: AsnC_trans_reg; pfam01037
232721011428	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
232721011429	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
232721011430	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721011431	catalytic residue [active]
232721011432	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
232721011433	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
232721011434	putative acyl-acceptor binding pocket; other site
232721011435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
232721011436	non-specific DNA binding site [nucleotide binding]; other site
232721011437	salt bridge; other site
232721011438	sequence-specific DNA binding site [nucleotide binding]; other site
232721011439	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
232721011440	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
232721011441	Protein required for attachment to host cells; Region: Host_attach; pfam10116
232721011442	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721011443	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
232721011444	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
232721011445	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
232721011446	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
232721011447	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
232721011448	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
232721011449	FIST N domain; Region: FIST; pfam08495
232721011450	FIST C domain; Region: FIST_C; pfam10442
232721011451	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
232721011452	IHF dimer interface [polypeptide binding]; other site
232721011453	IHF - DNA interface [nucleotide binding]; other site
232721011454	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
232721011455	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
232721011456	Response regulator receiver domain; Region: Response_reg; pfam00072
232721011457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721011458	active site
232721011459	phosphorylation site [posttranslational modification]
232721011460	intermolecular recognition site; other site
232721011461	dimerization interface [polypeptide binding]; other site
232721011462	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
232721011463	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721011464	dimerization interface [polypeptide binding]; other site
232721011465	PAS domain; Region: PAS; smart00091
232721011466	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
232721011467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721011468	dimer interface [polypeptide binding]; other site
232721011469	phosphorylation site [posttranslational modification]
232721011470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721011471	ATP binding site [chemical binding]; other site
232721011472	Mg2+ binding site [ion binding]; other site
232721011473	G-X-G motif; other site
232721011474	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
232721011475	16S rRNA methyltransferase B; Provisional; Region: PRK10901
232721011476	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
232721011477	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721011478	S-adenosylmethionine binding site [chemical binding]; other site
232721011479	LemA family; Region: LemA; cl00742
232721011480	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
232721011481	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
232721011482	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
232721011483	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
232721011484	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
232721011485	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
232721011486	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
232721011487	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
232721011488	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
232721011489	DNA binding site [nucleotide binding]
232721011490	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
232721011491	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
232721011492	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
232721011493	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
232721011494	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
232721011495	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
232721011496	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
232721011497	RPB3 interaction site [polypeptide binding]; other site
232721011498	RPB1 interaction site [polypeptide binding]; other site
232721011499	RPB11 interaction site [polypeptide binding]; other site
232721011500	RPB10 interaction site [polypeptide binding]; other site
232721011501	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
232721011502	peripheral dimer interface [polypeptide binding]; other site
232721011503	core dimer interface [polypeptide binding]; other site
232721011504	L10 interface [polypeptide binding]; other site
232721011505	L11 interface [polypeptide binding]; other site
232721011506	putative EF-Tu interaction site [polypeptide binding]; other site
232721011507	putative EF-G interaction site [polypeptide binding]; other site
232721011508	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
232721011509	23S rRNA interface [nucleotide binding]; other site
232721011510	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
232721011511	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
232721011512	mRNA/rRNA interface [nucleotide binding]; other site
232721011513	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
232721011514	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
232721011515	23S rRNA interface [nucleotide binding]; other site
232721011516	L7/L12 interface [polypeptide binding]; other site
232721011517	putative thiostrepton binding site; other site
232721011518	L25 interface [polypeptide binding]; other site
232721011519	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
232721011520	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
232721011521	putative homodimer interface [polypeptide binding]; other site
232721011522	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
232721011523	heterodimer interface [polypeptide binding]; other site
232721011524	homodimer interface [polypeptide binding]; other site
232721011525	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
232721011526	elongation factor Tu; Reviewed; Region: PRK00049
232721011527	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
232721011528	G1 box; other site
232721011529	GEF interaction site [polypeptide binding]; other site
232721011530	GTP/Mg2+ binding site [chemical binding]; other site
232721011531	Switch I region; other site
232721011532	G2 box; other site
232721011533	G3 box; other site
232721011534	Switch II region; other site
232721011535	G4 box; other site
232721011536	G5 box; other site
232721011537	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
232721011538	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
232721011539	Antibiotic Binding Site [chemical binding]; other site
232721011540	Transposase; Region: HTH_Tnp_1; cl17663
232721011541	glutathione synthetase; Provisional; Region: PRK05246
232721011542	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
232721011543	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
232721011544	benzoate transporter; Region: benE; TIGR00843
232721011545	Benzoate membrane transport protein; Region: BenE; pfam03594
232721011546	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
232721011547	potassium uptake protein; Region: kup; TIGR00794
232721011548	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
232721011549	Glutamate-cysteine ligase; Region: GshA; pfam08886
232721011550	Cation transport protein; Region: TrkH; cl17365
232721011551	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
232721011552	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
232721011553	TrkA-N domain; Region: TrkA_N; pfam02254
232721011554	TrkA-C domain; Region: TrkA_C; pfam02080
232721011555	TrkA-N domain; Region: TrkA_N; pfam02254
232721011556	TrkA-C domain; Region: TrkA_C; pfam02080
232721011557	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
232721011558	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
232721011559	putative catalytic cysteine [active]
232721011560	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
232721011561	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
232721011562	Lipopolysaccharide-assembly; Region: LptE; pfam04390
232721011563	leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396
232721011564	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
232721011565	HIGH motif; other site
232721011566	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
232721011567	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
232721011568	active site
232721011569	KMSKS motif; other site
232721011570	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
232721011571	tRNA binding surface [nucleotide binding]; other site
232721011572	Transposase domain (DUF772); Region: DUF772; pfam05598
232721011573	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
232721011574	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
232721011575	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
232721011576	Mechanosensitive ion channel; Region: MS_channel; pfam00924
232721011577	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
232721011578	TolR protein; Region: tolR; TIGR02801
232721011579	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
232721011580	dihydrodipicolinate reductase; Provisional; Region: PRK00048
232721011581	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
232721011582	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
232721011583	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
232721011584	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
232721011585	ferric uptake regulator; Provisional; Region: fur; PRK09462
232721011586	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
232721011587	metal binding site 2 [ion binding]; metal-binding site
232721011588	putative DNA binding helix; other site
232721011589	metal binding site 1 [ion binding]; metal-binding site
232721011590	dimer interface [polypeptide binding]; other site
232721011591	structural Zn2+ binding site [ion binding]; other site
232721011592	HPr kinase/phosphorylase; Provisional; Region: PRK05428
232721011593	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
232721011594	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
232721011595	Hpr binding site; other site
232721011596	active site
232721011597	homohexamer subunit interaction site [polypeptide binding]; other site
232721011598	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
232721011599	active site
232721011600	phosphorylation site [posttranslational modification]
232721011601	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
232721011602	30S subunit binding site; other site
232721011603	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
232721011604	active site
232721011605	ATP binding site [chemical binding]; other site
232721011606	substrate binding site [chemical binding]; other site
232721011607	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
232721011608	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
232721011609	N-terminal plug; other site
232721011610	ligand-binding site [chemical binding]; other site
232721011611	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
232721011612	META domain; Region: META; pfam03724
232721011613	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
232721011614	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
232721011615	intracellular protease, PfpI family; Region: PfpI; TIGR01382
232721011616	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
232721011617	conserved cys residue [active]
232721011618	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
232721011619	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
232721011620	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
232721011621	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
232721011622	ATP-grasp domain; Region: ATP-grasp; pfam02222
232721011623	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
232721011624	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
232721011625	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
232721011626	active site
232721011627	catalytic triad [active]
232721011628	oxyanion hole [active]
232721011629	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
232721011630	oxyanion hole [active]
232721011631	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
232721011632	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
232721011633	Glycoprotease family; Region: Peptidase_M22; pfam00814
232721011634	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
232721011635	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
232721011636	Coenzyme A binding pocket [chemical binding]; other site
232721011637	Ferredoxin [Energy production and conversion]; Region: COG1146
232721011638	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
232721011639	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
232721011640	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
232721011641	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
232721011642	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
232721011643	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
232721011644	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
232721011645	ThiS family; Region: ThiS; pfam02597
232721011646	charged pocket; other site
232721011647	hydrophobic patch; other site
232721011648	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
232721011649	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
232721011650	Cl binding site [ion binding]; other site
232721011651	oligomer interface [polypeptide binding]; other site
232721011652	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
232721011653	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
232721011654	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
232721011655	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
232721011656	acyl-activating enzyme (AAE) consensus motif; other site
232721011657	putative AMP binding site [chemical binding]; other site
232721011658	putative active site [active]
232721011659	putative CoA binding site [chemical binding]; other site
232721011660	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
232721011661	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
232721011662	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
232721011663	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
232721011664	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
232721011665	ligand binding site [chemical binding]; other site
232721011666	homodimer interface [polypeptide binding]; other site
232721011667	NAD(P) binding site [chemical binding]; other site
232721011668	trimer interface B [polypeptide binding]; other site
232721011669	trimer interface A [polypeptide binding]; other site
232721011670	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
232721011671	intersubunit interface [polypeptide binding]; other site
232721011672	active site
232721011673	zinc binding site [ion binding]; other site
232721011674	Na+ binding site [ion binding]; other site
232721011675	pyruvate kinase; Provisional; Region: PRK05826
232721011676	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
232721011677	domain interfaces; other site
232721011678	active site
232721011679	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
232721011680	proline aminopeptidase P II; Provisional; Region: PRK10879
232721011681	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
232721011682	active site
232721011683	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
232721011684	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
232721011685	Substrate binding site; other site
232721011686	metal-binding site
232721011687	transketolase; Reviewed; Region: PRK12753
232721011688	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
232721011689	TPP-binding site [chemical binding]; other site
232721011690	dimer interface [polypeptide binding]; other site
232721011691	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
232721011692	PYR/PP interface [polypeptide binding]; other site
232721011693	dimer interface [polypeptide binding]; other site
232721011694	TPP binding site [chemical binding]; other site
232721011695	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
232721011696	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
232721011697	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
232721011698	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
232721011699	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
232721011700	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
232721011701	Peptidase C26; Region: Peptidase_C26; pfam07722
232721011702	catalytic triad [active]
232721011703	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
232721011704	Pirin-related protein [General function prediction only]; Region: COG1741
232721011705	Pirin; Region: Pirin; pfam02678
232721011706	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
232721011707	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
232721011708	dimer interface [polypeptide binding]; other site
232721011709	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
232721011710	short chain dehydrogenase; Provisional; Region: PRK08267
232721011711	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
232721011712	putative NAD(P) binding site [chemical binding]; other site
232721011713	active site
232721011714	Uncharacterized conserved protein [Function unknown]; Region: COG3148
232721011715	Transcriptional regulator [Transcription]; Region: IclR; COG1414
232721011716	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
232721011717	Bacterial transcriptional regulator; Region: IclR; pfam01614
232721011718	thiolase; Provisional; Region: PRK06158
232721011719	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
232721011720	active site
232721011721	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
232721011722	DUF35 OB-fold domain; Region: DUF35; pfam01796
232721011723	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721011724	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
232721011725	CoA binding domain; Region: CoA_binding_2; pfam13380
232721011726	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
232721011727	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
232721011728	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
232721011729	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
232721011730	C-terminal domain interface [polypeptide binding]; other site
232721011731	GSH binding site (G-site) [chemical binding]; other site
232721011732	dimer interface [polypeptide binding]; other site
232721011733	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
232721011734	dimer interface [polypeptide binding]; other site
232721011735	N-terminal domain interface [polypeptide binding]; other site
232721011736	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642
232721011737	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721011738	NAD(P) binding site [chemical binding]; other site
232721011739	active site
232721011740	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
232721011741	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
232721011742	Protein of unknown function (DUF1010); Region: DUF1010; pfam06231
232721011743	LabA_like proteins; Region: LabA_like; cd06167
232721011744	putative metal binding site [ion binding]; other site
232721011745	Uncharacterized conserved protein [Function unknown]; Region: COG1432
232721011746	DNA topoisomerase III; Provisional; Region: PRK14724
232721011747	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
232721011748	active site
232721011749	putative interdomain interaction site [polypeptide binding]; other site
232721011750	putative metal-binding site [ion binding]; other site
232721011751	putative nucleotide binding site [chemical binding]; other site
232721011752	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
232721011753	domain I; other site
232721011754	DNA binding groove [nucleotide binding]
232721011755	phosphate binding site [ion binding]; other site
232721011756	domain II; other site
232721011757	domain III; other site
232721011758	nucleotide binding site [chemical binding]; other site
232721011759	catalytic site [active]
232721011760	domain IV; other site
232721011761	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
232721011762	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
232721011763	SWI complex, BAF60b domains; Region: SWIB; smart00151
232721011764	Proteins containing SET domain [General function prediction only]; Region: COG2940
232721011765	SET domain; Region: SET; pfam00856
232721011766	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
232721011767	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
232721011768	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
232721011769	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721011770	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
232721011771	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
232721011772	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
232721011773	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721011774	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
232721011775	dimerization interface [polypeptide binding]; other site
232721011776	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
232721011777	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721011778	dimer interface [polypeptide binding]; other site
232721011779	phosphorylation site [posttranslational modification]
232721011780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721011781	ATP binding site [chemical binding]; other site
232721011782	Mg2+ binding site [ion binding]; other site
232721011783	G-X-G motif; other site
232721011784	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
232721011785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721011786	active site
232721011787	phosphorylation site [posttranslational modification]
232721011788	intermolecular recognition site; other site
232721011789	dimerization interface [polypeptide binding]; other site
232721011790	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721011791	DNA binding site [nucleotide binding]
232721011792	Transcriptional regulators [Transcription]; Region: MarR; COG1846
232721011793	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
232721011794	recombinase A; Provisional; Region: recA; PRK09354
232721011795	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
232721011796	hexamer interface [polypeptide binding]; other site
232721011797	Walker A motif; other site
232721011798	ATP binding site [chemical binding]; other site
232721011799	Walker B motif; other site
232721011800	RecX family; Region: RecX; cl00936
232721011801	Protein of unknown function (DUF1631); Region: DUF1631; pfam07793
232721011802	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
232721011803	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
232721011804	Protein export membrane protein; Region: SecD_SecF; pfam02355
232721011805	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
232721011806	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
232721011807	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
232721011808	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
232721011809	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
232721011810	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
232721011811	Mechanosensitive ion channel; Region: MS_channel; pfam00924
232721011812	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
232721011813	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
232721011814	dimer interface [polypeptide binding]; other site
232721011815	PYR/PP interface [polypeptide binding]; other site
232721011816	TPP binding site [chemical binding]; other site
232721011817	substrate binding site [chemical binding]; other site
232721011818	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
232721011819	TPP-binding site; other site
232721011820	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
232721011821	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
232721011822	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
232721011823	putative DNA binding site [nucleotide binding]; other site
232721011824	putative Zn2+ binding site [ion binding]; other site
232721011825	AsnC family; Region: AsnC_trans_reg; pfam01037
232721011826	Transmembrane secretion effector; Region: MFS_3; pfam05977
232721011827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721011828	putative substrate translocation pore; other site
232721011829	MltA specific insert domain; Region: MltA; smart00925
232721011830	3D domain; Region: 3D; pfam06725
232721011831	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
232721011832	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
232721011833	ligand binding site [chemical binding]; other site
232721011834	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
232721011835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721011836	active site
232721011837	phosphorylation site [posttranslational modification]
232721011838	intermolecular recognition site; other site
232721011839	dimerization interface [polypeptide binding]; other site
232721011840	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
232721011841	DNA binding residues [nucleotide binding]
232721011842	dimerization interface [polypeptide binding]; other site
232721011843	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
232721011844	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
232721011845	putative active site [active]
232721011846	heme pocket [chemical binding]; other site
232721011847	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
232721011848	dimer interface [polypeptide binding]; other site
232721011849	phosphorylation site [posttranslational modification]
232721011850	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721011851	ATP binding site [chemical binding]; other site
232721011852	Mg2+ binding site [ion binding]; other site
232721011853	G-X-G motif; other site
232721011854	nitrilase; Region: PLN02798
232721011855	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
232721011856	putative active site [active]
232721011857	catalytic triad [active]
232721011858	dimer interface [polypeptide binding]; other site
232721011859	Protein of unknown function; Region: DUF3971; pfam13116
232721011860	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
232721011861	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
232721011862	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
232721011863	metal binding triad; other site
232721011864	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
232721011865	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
232721011866	metal binding triad; other site
232721011867	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
232721011868	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
232721011869	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
232721011870	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
232721011871	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
232721011872	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
232721011873	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
232721011874	HlyD family secretion protein; Region: HlyD_3; pfam13437
232721011875	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
232721011876	Protein export membrane protein; Region: SecD_SecF; cl14618
232721011877	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
232721011878	catalytic residues [active]
232721011879	dimer interface [polypeptide binding]; other site
232721011880	putative glutathione S-transferase; Provisional; Region: PRK10357
232721011881	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
232721011882	putative C-terminal domain interface [polypeptide binding]; other site
232721011883	putative GSH binding site (G-site) [chemical binding]; other site
232721011884	putative dimer interface [polypeptide binding]; other site
232721011885	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
232721011886	dimer interface [polypeptide binding]; other site
232721011887	N-terminal domain interface [polypeptide binding]; other site
232721011888	adenylosuccinate lyase; Provisional; Region: PRK09285
232721011889	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
232721011890	tetramer interface [polypeptide binding]; other site
232721011891	active site
232721011892	YaeQ protein; Region: YaeQ; pfam07152
232721011893	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
232721011894	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
232721011895	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
232721011896	yybP-ykoY element as predicted by Rfam (RF00080), score 35.78
232721011897	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
232721011898	Predicted membrane protein [Function unknown]; Region: COG1950
232721011899	Peptidase family M48; Region: Peptidase_M48; pfam01435
232721011900	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
232721011901	trimer interface [polypeptide binding]; other site
232721011902	dimer interface [polypeptide binding]; other site
232721011903	putative active site [active]
232721011904	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
232721011905	active site
232721011906	NTP binding site [chemical binding]; other site
232721011907	metal binding triad [ion binding]; metal-binding site
232721011908	antibiotic binding site [chemical binding]; other site
232721011909	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
232721011910	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
232721011911	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
232721011912	trimer interface [polypeptide binding]; other site
232721011913	dimer interface [polypeptide binding]; other site
232721011914	putative active site [active]
232721011915	Pilin (bacterial filament); Region: Pilin; pfam00114
232721011916	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721011917	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721011918	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721011919	Transposase; Region: DEDD_Tnp_IS110; pfam01548
232721011920	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
232721011921	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
232721011922	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
232721011923	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
232721011924	phosphopeptide binding site; other site
232721011925	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
232721011926	active site
232721011927	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
232721011928	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
232721011929	CoA binding domain; Region: CoA_binding; smart00881
232721011930	CoA-ligase; Region: Ligase_CoA; pfam00549
232721011931	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
232721011932	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
232721011933	CoA-ligase; Region: Ligase_CoA; pfam00549
232721011934	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
232721011935	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
232721011936	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
232721011937	DNA protecting protein DprA; Region: dprA; TIGR00732
232721011938	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
232721011939	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
232721011940	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
232721011941	active site
232721011942	catalytic residues [active]
232721011943	metal binding site [ion binding]; metal-binding site
232721011944	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
232721011945	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
232721011946	putative active site [active]
232721011947	substrate binding site [chemical binding]; other site
232721011948	putative cosubstrate binding site; other site
232721011949	catalytic site [active]
232721011950	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
232721011951	substrate binding site [chemical binding]; other site
232721011952	AzlC protein; Region: AzlC; pfam03591
232721011953	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
232721011954	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
232721011955	Phosphoglycerate kinase; Region: PGK; pfam00162
232721011956	substrate binding site [chemical binding]; other site
232721011957	hinge regions; other site
232721011958	ADP binding site [chemical binding]; other site
232721011959	catalytic site [active]
232721011960	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
232721011961	EamA-like transporter family; Region: EamA; pfam00892
232721011962	EamA-like transporter family; Region: EamA; pfam00892
232721011963	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
232721011964	active site
232721011965	dimer interface [polypeptide binding]; other site
232721011966	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721011967	LysR substrate binding domain; Region: LysR_substrate; pfam03466
232721011968	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721011969	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
232721011970	active site
232721011971	Zn binding site [ion binding]; other site
232721011972	Nitrate and nitrite sensing; Region: NIT; pfam08376
232721011973	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721011974	dimerization interface [polypeptide binding]; other site
232721011975	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721011976	dimer interface [polypeptide binding]; other site
232721011977	putative CheW interface [polypeptide binding]; other site
232721011978	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
232721011979	Na binding site [ion binding]; other site
232721011980	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
232721011981	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
232721011982	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
232721011983	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
232721011984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
232721011985	Major Facilitator Superfamily; Region: MFS_1; pfam07690
232721011986	putative substrate translocation pore; other site
232721011987	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
232721011988	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
232721011989	dimer interface [polypeptide binding]; other site
232721011990	ssDNA binding site [nucleotide binding]; other site
232721011991	tetramer (dimer of dimers) interface [polypeptide binding]; other site
232721011992	L-lactate permease; Region: Lactate_perm; cl00701
232721011993	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
232721011994	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
232721011995	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
232721011996	Ligand Binding Site [chemical binding]; other site
232721011997	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
232721011998	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721011999	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
232721012000	putative dimerization interface [polypeptide binding]; other site
232721012001	tricarballylate dehydrogenase; Validated; Region: PRK08274
232721012002	tricarballylate utilization protein B; Provisional; Region: PRK15033
232721012003	Homeodomain-like domain; Region: HTH_23; pfam13384
232721012004	Winged helix-turn helix; Region: HTH_29; pfam13551
232721012005	Homeodomain-like domain; Region: HTH_32; pfam13565
232721012006	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721012007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721012008	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
232721012009	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
232721012010	nudix motif; other site
232721012011	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
232721012012	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
232721012013	N-terminal plug; other site
232721012014	ligand-binding site [chemical binding]; other site
232721012015	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
232721012016	Lumazine binding domain; Region: Lum_binding; pfam00677
232721012017	Lumazine binding domain; Region: Lum_binding; pfam00677
232721012018	head completion protein; Provisional; Region: 4; PHA02552
232721012019	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
232721012020	Predicted ATPase [General function prediction only]; Region: COG4637
232721012021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721012022	Walker A/P-loop; other site
232721012023	ATP binding site [chemical binding]; other site
232721012024	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
232721012025	DNA methylase; Region: N6_N4_Mtase; cl17433
232721012026	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
232721012027	DNA methylase; Region: N6_N4_Mtase; pfam01555
232721012028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
232721012029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721012030	ATP binding site [chemical binding]; other site
232721012031	Mg2+ binding site [ion binding]; other site
232721012032	G-X-G motif; other site
232721012033	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
232721012034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
232721012035	active site
232721012036	phosphorylation site [posttranslational modification]
232721012037	intermolecular recognition site; other site
232721012038	dimerization interface [polypeptide binding]; other site
232721012039	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
232721012040	DNA binding site [nucleotide binding]
232721012041	Predicted membrane protein [Function unknown]; Region: COG3212
232721012042	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
232721012043	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
232721012044	Cobalt transport protein; Region: CbiQ; cl00463
232721012045	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
232721012046	FAD binding pocket [chemical binding]; other site
232721012047	FAD binding motif [chemical binding]; other site
232721012048	phosphate binding motif [ion binding]; other site
232721012049	beta-alpha-beta structure motif; other site
232721012050	NAD binding pocket [chemical binding]; other site
232721012051	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
232721012052	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
232721012053	Flavodoxin; Region: Flavodoxin_1; pfam00258
232721012054	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide.  Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201
232721012055	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
232721012056	FAD binding pocket [chemical binding]; other site
232721012057	FAD binding motif [chemical binding]; other site
232721012058	catalytic residues [active]
232721012059	NAD binding pocket [chemical binding]; other site
232721012060	phosphate binding motif [ion binding]; other site
232721012061	beta-alpha-beta structure motif; other site
232721012062	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
232721012063	ApbE family; Region: ApbE; pfam02424
232721012064	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
232721012065	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
232721012066	spermidine synthase; Provisional; Region: PRK03612
232721012067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721012068	S-adenosylmethionine binding site [chemical binding]; other site
232721012069	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
232721012070	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
232721012071	DNA methylase; Region: N6_N4_Mtase; pfam01555
232721012072	DNA methylase; Region: N6_N4_Mtase; pfam01555
232721012073	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
232721012074	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
232721012075	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
232721012076	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
232721012077	Short C-terminal domain; Region: SHOCT; pfam09851
232721012078	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
232721012079	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
232721012080	Transcriptional regulator [Transcription]; Region: LysR; COG0583
232721012081	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
232721012082	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
232721012083	dimerization interface [polypeptide binding]; other site
232721012084	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
232721012085	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
232721012086	inhibitor-cofactor binding pocket; inhibition site
232721012087	pyridoxal 5'-phosphate binding site [chemical binding]; other site
232721012088	catalytic residue [active]
232721012089	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
232721012090	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
232721012091	tetrameric interface [polypeptide binding]; other site
232721012092	NAD binding site [chemical binding]; other site
232721012093	catalytic residues [active]
232721012094	malic enzyme; Reviewed; Region: PRK12862
232721012095	Malate dehydrogenase enzyme; Region: Malate_DH; pfam12434
232721012096	Malic enzyme, N-terminal domain; Region: malic; pfam00390
232721012097	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
232721012098	putative NAD(P) binding site [chemical binding]; other site
232721012099	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
232721012100	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
232721012101	active site
232721012102	barstar interaction site; other site
232721012103	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
232721012104	putative RNAase interaction site [polypeptide binding]; other site
232721012105	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
232721012106	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
232721012107	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
232721012108	SurA N-terminal domain; Region: SurA_N; pfam09312
232721012109	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
232721012110	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
232721012111	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
232721012112	OstA-like protein; Region: OstA; cl00844
232721012113	Organic solvent tolerance protein; Region: OstA_C; pfam04453
232721012114	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
232721012115	Phosphotransferase enzyme family; Region: APH; pfam01636
232721012116	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
232721012117	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
232721012118	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721012119	Walker A/P-loop; other site
232721012120	ATP binding site [chemical binding]; other site
232721012121	Q-loop/lid; other site
232721012122	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
232721012123	AAA domain; Region: AAA_21; pfam13304
232721012124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
232721012125	ABC transporter signature motif; other site
232721012126	Walker B; other site
232721012127	D-loop; other site
232721012128	H-loop/switch region; other site
232721012129	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721012130	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721012131	metal binding site [ion binding]; metal-binding site
232721012132	active site
232721012133	I-site; other site
232721012134	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
232721012135	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
232721012136	PGAP1-like protein; Region: PGAP1; pfam07819
232721012137	hypothetical protein; Provisional; Region: PRK07907
232721012138	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
232721012139	metal binding site [ion binding]; metal-binding site
232721012140	putative dimer interface [polypeptide binding]; other site
232721012141	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
232721012142	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
232721012143	metal binding site [ion binding]; metal-binding site
232721012144	active site
232721012145	I-site; other site
232721012146	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
232721012147	dimerization interface [polypeptide binding]; other site
232721012148	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
232721012149	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
232721012150	dimer interface [polypeptide binding]; other site
232721012151	putative CheW interface [polypeptide binding]; other site
232721012152	Methyltransferase domain; Region: Methyltransf_23; pfam13489
232721012153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
232721012154	S-adenosylmethionine binding site [chemical binding]; other site
232721012155	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
232721012156	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
232721012157	Predicted membrane protein [Function unknown]; Region: COG2119
232721012158	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
232721012159	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
232721012160	yybP-ykoY element as predicted by Rfam (RF00080), score 42.21
232721012161	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
232721012162	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
232721012163	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
232721012164	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
232721012165	short chain dehydrogenase; Provisional; Region: PRK07024
232721012166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
232721012167	NAD(P) binding site [chemical binding]; other site
232721012168	active site
232721012169	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
232721012170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
232721012171	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
232721012172	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
232721012173	active site
232721012174	motif I; other site
232721012175	motif II; other site
232721012176	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
232721012177	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
232721012178	putative active site [active]
232721012179	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
232721012180	putative cation:proton antiport protein; Provisional; Region: PRK10669
232721012181	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
232721012182	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
232721012183	TrkA-N domain; Region: TrkA_N; pfam02254
232721012184	TrkA-C domain; Region: TrkA_C; pfam02080
232721012185	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
232721012186	active site
232721012187	Homeodomain-like domain; Region: HTH_23; pfam13384
232721012188	Winged helix-turn helix; Region: HTH_29; pfam13551
232721012189	Homeodomain-like domain; Region: HTH_32; pfam13565
232721012190	DDE superfamily endonuclease; Region: DDE_3; pfam13358
232721012191	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
232721012192	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
232721012193	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
232721012194	ligand binding site [chemical binding]; other site
232721012195	flexible hinge region; other site
232721012196	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
232721012197	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
232721012198	trmE is a tRNA modification GTPase; Region: trmE; cd04164
232721012199	G1 box; other site
232721012200	GTP/Mg2+ binding site [chemical binding]; other site
232721012201	Switch I region; other site
232721012202	G2 box; other site
232721012203	Switch II region; other site
232721012204	G3 box; other site
232721012205	G4 box; other site
232721012206	G5 box; other site
232721012207	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
232721012208	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
232721012209	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
232721012210	membrane protein insertase; Provisional; Region: PRK01318
232721012211	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
232721012212	hypothetical protein; Provisional; Region: PRK14389
232721012213	Ribonuclease P; Region: Ribonuclease_P; pfam00825
232721012214	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
232721012215	DnaA N-terminal domain; Region: DnaA_N; pfam11638
232721012216	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
232721012217	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
232721012218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
232721012219	Walker A motif; other site
232721012220	ATP binding site [chemical binding]; other site
232721012221	Walker B motif; other site
232721012222	arginine finger; other site
232721012223	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
232721012224	DnaA box-binding interface [nucleotide binding]; other site
232721012225	DNA polymerase III subunit beta; Validated; Region: PRK05643
232721012226	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
232721012227	putative DNA binding surface [nucleotide binding]; other site
232721012228	dimer interface [polypeptide binding]; other site
232721012229	beta-clamp/clamp loader binding surface; other site
232721012230	beta-clamp/translesion DNA polymerase binding surface; other site
232721012231	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
232721012232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
232721012233	ATP binding site [chemical binding]; other site
232721012234	Mg2+ binding site [ion binding]; other site
232721012235	G-X-G motif; other site
232721012236	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
232721012237	anchoring element; other site
232721012238	dimer interface [polypeptide binding]; other site
232721012239	ATP binding site [chemical binding]; other site
232721012240	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
232721012241	active site
232721012242	putative metal-binding site [ion binding]; other site
232721012243	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
232721012244	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
232721012245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
232721012246	Coenzyme A binding pocket [chemical binding]; other site
232721012247	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
232721012248	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
232721012249	Protein of unknown function DUF72; Region: DUF72; pfam01904
232721012250	Acylphosphatase; Region: Acylphosphatase; pfam00708
232721012251	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
232721012252	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
232721012253	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
232721012254	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
232721012255	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
232721012256	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
232721012257	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
232721012258	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
232721012259	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
232721012260	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
232721012261	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
232721012262	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
232721012263	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
232721012264	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
232721012265	active site
232721012266	catalytic site [active]
232721012267	substrate binding site [chemical binding]; other site
232721012268	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
232721012269	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
232721012270	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
232721012271	DNA-binding site [nucleotide binding]; DNA binding site
232721012272	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
232721012273	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
232721012274	catalytic residue [active]