-- dump date   	20140618_185141
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
240015000001	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
240015000002	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
240015000003	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
240015000004	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
240015000005	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
240015000006	Cysteine-rich domain; Region: CCG; pfam02754
240015000007	Cysteine-rich domain; Region: CCG; pfam02754
240015000008	Uncharacterized conserved protein [Function unknown]; Region: COG3538
240015000009	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
240015000010	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
240015000011	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
240015000012	multidrug efflux system protein MdtO; Provisional; Region: PRK11427
240015000013	multidrug resistance protein MdtN; Provisional; Region: PRK10476
240015000014	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015000015	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015000016	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
240015000017	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
240015000018	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
240015000019	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
240015000020	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
240015000021	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
240015000022	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240015000023	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
240015000024	putative dimerization interface [polypeptide binding]; other site
240015000025	Carboxylesterase family; Region: COesterase; pfam00135
240015000026	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
240015000027	substrate binding pocket [chemical binding]; other site
240015000028	catalytic triad [active]
240015000029	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
240015000030	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
240015000031	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
240015000032	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
240015000033	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
240015000034	putative ATP binding site [chemical binding]; other site
240015000035	putative substrate binding site [chemical binding]; other site
240015000036	Transcriptional regulators [Transcription]; Region: GntR; COG1802
240015000037	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
240015000038	DNA-binding site [nucleotide binding]; DNA binding site
240015000039	Transcriptional regulators [Transcription]; Region: PurR; COG1609
240015000040	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
240015000041	ligand binding site [chemical binding]; other site
240015000042	dimerization interface [polypeptide binding]; other site
240015000043	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015000044	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
240015000045	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
240015000046	substrate binding [chemical binding]; other site
240015000047	active site
240015000048	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
240015000049	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015000050	BNR repeat-like domain; Region: BNR_2; pfam13088
240015000051	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
240015000052	active site
240015000053	catalytic triad [active]
240015000054	oxyanion hole [active]
240015000055	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
240015000056	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
240015000057	dimer interface [polypeptide binding]; other site
240015000058	active site
240015000059	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
240015000060	dimer interface [polypeptide binding]; other site
240015000061	active site
240015000062	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
240015000063	A functionally uncharacterized subgroup of  the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in...; Region: GH20_chitobiase-like_1; cd06570
240015000064	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
240015000065	active site
240015000066	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
240015000067	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
240015000068	active site
240015000069	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
240015000070	fructuronate transporter; Provisional; Region: PRK10034; cl15264
240015000071	GntP family permease; Region: GntP_permease; pfam02447
240015000072	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
240015000073	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
240015000074	active site
240015000075	putative substrate binding pocket [chemical binding]; other site
240015000076	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
240015000077	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
240015000078	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
240015000079	dimer interface [polypeptide binding]; other site
240015000080	active site
240015000081	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
240015000082	substrate binding site [chemical binding]; other site
240015000083	catalytic residue [active]
240015000084	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
240015000085	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
240015000086	active site
240015000087	Glyco_18 domain; Region: Glyco_18; smart00636
240015000088	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
240015000089	active site
240015000090	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
240015000091	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
240015000092	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
240015000093	aromatic chitin/cellulose binding site residues [chemical binding]; other site
240015000094	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
240015000095	Interdomain contacts; other site
240015000096	Cytokine receptor motif; other site
240015000097	Glyco_18 domain; Region: Glyco_18; smart00636
240015000098	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
240015000099	active site
240015000100	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
240015000101	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
240015000102	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
240015000103	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
240015000104	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015000105	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
240015000106	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000107	binding surface
240015000108	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240015000109	TPR motif; other site
240015000110	TPR repeat; Region: TPR_11; pfam13414
240015000111	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000112	TPR motif; other site
240015000113	binding surface
240015000114	TPR repeat; Region: TPR_11; pfam13414
240015000115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000116	binding surface
240015000117	TPR motif; other site
240015000118	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240015000119	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
240015000120	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
240015000121	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240015000122	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240015000123	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240015000124	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
240015000125	Probable Catalytic site; other site
240015000126	metal-binding site
240015000127	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
240015000128	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
240015000129	alpha-galactosidase; Region: PLN02808; cl17638
240015000130	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
240015000131	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
240015000132	TPP-binding site [chemical binding]; other site
240015000133	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
240015000134	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
240015000135	Putative addiction module component; Region: Unstab_antitox; cl09921
240015000136	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
240015000137	DNA-binding site [nucleotide binding]; DNA binding site
240015000138	RNA-binding motif; other site
240015000139	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
240015000140	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
240015000141	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
240015000142	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
240015000143	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015000144	FeS/SAM binding site; other site
240015000145	P-loop containing region of AAA domain; Region: AAA_29; cl17516
240015000146	AAA domain; Region: AAA_23; pfam13476
240015000147	AAA domain; Region: AAA_21; pfam13304
240015000148	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015000149	Q-loop/lid; other site
240015000150	ABC transporter signature motif; other site
240015000151	Walker B; other site
240015000152	D-loop; other site
240015000153	H-loop/switch region; other site
240015000154	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
240015000155	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
240015000156	putative substrate binding pocket [chemical binding]; other site
240015000157	dimer interface [polypeptide binding]; other site
240015000158	phosphate binding site [ion binding]; other site
240015000159	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240015000160	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240015000161	binding surface
240015000162	TPR motif; other site
240015000163	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
240015000164	PIN domain; Region: PIN_3; cl17397
240015000165	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
240015000166	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
240015000167	dimer interface [polypeptide binding]; other site
240015000168	active site
240015000169	Transcriptional regulators [Transcription]; Region: PurR; COG1609
240015000170	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
240015000171	DNA binding site [nucleotide binding]
240015000172	domain linker motif; other site
240015000173	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
240015000174	ligand binding site [chemical binding]; other site
240015000175	dimerization interface [polypeptide binding]; other site
240015000176	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
240015000177	Melibiase; Region: Melibiase; pfam02065
240015000178	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015000179	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015000180	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015000181	TPR repeat; Region: TPR_11; pfam13414
240015000182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000183	binding surface
240015000184	TPR motif; other site
240015000185	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000186	TPR motif; other site
240015000187	TPR repeat; Region: TPR_11; pfam13414
240015000188	binding surface
240015000189	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
240015000190	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
240015000191	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
240015000192	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
240015000193	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
240015000194	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
240015000195	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240015000196	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
240015000197	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240015000198	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
240015000199	DXD motif; other site
240015000200	PilZ domain; Region: PilZ; pfam07238
240015000201	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
240015000202	endo-1,4-D-glucanase; Provisional; Region: PRK11097
240015000203	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
240015000204	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
240015000205	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
240015000206	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
240015000207	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
240015000208	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
240015000209	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
240015000210	Ligand Binding Site [chemical binding]; other site
240015000211	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
240015000212	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240015000213	dimerization interface [polypeptide binding]; other site
240015000214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015000215	ATP binding site [chemical binding]; other site
240015000216	Mg2+ binding site [ion binding]; other site
240015000217	G-X-G motif; other site
240015000218	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
240015000219	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
240015000220	Cl- selectivity filter; other site
240015000221	Cl- binding residues [ion binding]; other site
240015000222	pore gating glutamate residue; other site
240015000223	dimer interface [polypeptide binding]; other site
240015000224	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
240015000225	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000226	binding surface
240015000227	TPR motif; other site
240015000228	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
240015000229	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
240015000230	Ligand Binding Site [chemical binding]; other site
240015000231	Protein of unknown function DUF111; Region: DUF111; pfam01969
240015000232	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
240015000233	AIR carboxylase; Region: AIRC; smart01001
240015000234	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
240015000235	isocitrate dehydrogenase; Validated; Region: PRK07362
240015000236	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
240015000237	malate dehydrogenase; Reviewed; Region: PRK06223
240015000238	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
240015000239	NAD(P) binding site [chemical binding]; other site
240015000240	dimer interface [polypeptide binding]; other site
240015000241	tetramer (dimer of dimers) interface [polypeptide binding]; other site
240015000242	substrate binding site [chemical binding]; other site
240015000243	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
240015000244	putative active site [active]
240015000245	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
240015000246	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
240015000247	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
240015000248	active site
240015000249	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
240015000250	active site
240015000251	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240015000252	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
240015000253	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240015000254	putative active site [active]
240015000255	heme pocket [chemical binding]; other site
240015000256	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240015000257	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015000258	putative active site [active]
240015000259	heme pocket [chemical binding]; other site
240015000260	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015000261	putative active site [active]
240015000262	heme pocket [chemical binding]; other site
240015000263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
240015000264	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
240015000265	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
240015000266	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
240015000267	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
240015000268	L-aspartate oxidase; Provisional; Region: PRK06175
240015000269	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
240015000270	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
240015000271	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
240015000272	putative Iron-sulfur protein interface [polypeptide binding]; other site
240015000273	proximal heme binding site [chemical binding]; other site
240015000274	distal heme binding site [chemical binding]; other site
240015000275	putative dimer interface [polypeptide binding]; other site
240015000276	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
240015000277	active site
240015000278	dimerization interface [polypeptide binding]; other site
240015000279	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
240015000280	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
240015000281	minor groove reading motif; other site
240015000282	helix-hairpin-helix signature motif; other site
240015000283	active site
240015000284	Homeodomain-like domain; Region: HTH_23; cl17451
240015000285	Integrase core domain; Region: rve; pfam00665
240015000286	Integrase core domain; Region: rve_3; pfam13683
240015000287	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
240015000288	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
240015000289	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
240015000290	ligand binding site [chemical binding]; other site
240015000291	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
240015000292	Flagellar protein (FlbD); Region: FlbD; pfam06289
240015000293	flagellin; Reviewed; Region: PRK08869
240015000294	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
240015000295	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
240015000296	flagellar capping protein; Reviewed; Region: fliD; PRK08032
240015000297	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
240015000298	Flagellar protein FliS; Region: FliS; cl00654
240015000299	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240015000300	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240015000301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015000302	Walker A/P-loop; other site
240015000303	ATP binding site [chemical binding]; other site
240015000304	Q-loop/lid; other site
240015000305	ABC transporter signature motif; other site
240015000306	Walker B; other site
240015000307	D-loop; other site
240015000308	H-loop/switch region; other site
240015000309	Predicted permeases [General function prediction only]; Region: COG0795
240015000310	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
240015000311	Predicted permeases [General function prediction only]; Region: COG0795
240015000312	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
240015000313	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
240015000314	Uncharacterized conserved protein [Function unknown]; Region: COG3391
240015000315	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
240015000316	Phosphoesterase family; Region: Phosphoesterase; pfam04185
240015000317	Response regulator receiver domain; Region: Response_reg; pfam00072
240015000318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015000319	active site
240015000320	phosphorylation site [posttranslational modification]
240015000321	intermolecular recognition site; other site
240015000322	dimerization interface [polypeptide binding]; other site
240015000323	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015000324	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015000325	metal binding site [ion binding]; metal-binding site
240015000326	active site
240015000327	I-site; other site
240015000328	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
240015000329	thiamine phosphate binding site [chemical binding]; other site
240015000330	active site
240015000331	pyrophosphate binding site [ion binding]; other site
240015000332	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
240015000333	amino acid transporter; Region: 2A0306; TIGR00909
240015000334	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
240015000335	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
240015000336	phosphofructokinase; Region: PFK_mixed; TIGR02483
240015000337	active site
240015000338	ADP/pyrophosphate binding site [chemical binding]; other site
240015000339	dimerization interface [polypeptide binding]; other site
240015000340	allosteric effector site; other site
240015000341	fructose-1,6-bisphosphate binding site; other site
240015000342	Helix-turn-helix domain; Region: HTH_17; pfam12728
240015000343	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
240015000344	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
240015000345	putative trimer interface [polypeptide binding]; other site
240015000346	putative active site [active]
240015000347	putative substrate binding site [chemical binding]; other site
240015000348	putative CoA binding site [chemical binding]; other site
240015000349	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
240015000350	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
240015000351	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
240015000352	active site
240015000353	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
240015000354	carboxyltransferase (CT) interaction site; other site
240015000355	biotinylation site [posttranslational modification]; other site
240015000356	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
240015000357	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
240015000358	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
240015000359	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
240015000360	DinB superfamily; Region: DinB_2; pfam12867
240015000361	DinB family; Region: DinB; cl17821
240015000362	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
240015000363	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
240015000364	dimer interface [polypeptide binding]; other site
240015000365	putative CheW interface [polypeptide binding]; other site
240015000366	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
240015000367	oligomeric interface; other site
240015000368	putative active site [active]
240015000369	homodimer interface [polypeptide binding]; other site
240015000370	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
240015000371	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
240015000372	BioY family; Region: BioY; pfam02632
240015000373	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
240015000374	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
240015000375	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
240015000376	active site
240015000377	substrate binding site [chemical binding]; other site
240015000378	metal binding site [ion binding]; metal-binding site
240015000379	Septum formation initiator; Region: DivIC; pfam04977
240015000380	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
240015000381	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
240015000382	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240015000383	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
240015000384	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
240015000385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015000386	H+ Antiporter protein; Region: 2A0121; TIGR00900
240015000387	putative substrate translocation pore; other site
240015000388	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
240015000389	16S/18S rRNA binding site [nucleotide binding]; other site
240015000390	S13e-L30e interaction site [polypeptide binding]; other site
240015000391	25S rRNA binding site [nucleotide binding]; other site
240015000392	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
240015000393	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
240015000394	RNase E interface [polypeptide binding]; other site
240015000395	trimer interface [polypeptide binding]; other site
240015000396	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
240015000397	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
240015000398	RNase E interface [polypeptide binding]; other site
240015000399	trimer interface [polypeptide binding]; other site
240015000400	active site
240015000401	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
240015000402	putative nucleic acid binding region [nucleotide binding]; other site
240015000403	G-X-X-G motif; other site
240015000404	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
240015000405	RNA binding site [nucleotide binding]; other site
240015000406	domain interface; other site
240015000407	DinB superfamily; Region: DinB_2; pfam12867
240015000408	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
240015000409	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
240015000410	hinge; other site
240015000411	active site
240015000412	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
240015000413	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
240015000414	putative active site [active]
240015000415	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
240015000416	Beta-lactamase; Region: Beta-lactamase; pfam00144
240015000417	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
240015000418	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
240015000419	Catalytic site [active]
240015000420	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015000421	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015000422	metal binding site [ion binding]; metal-binding site
240015000423	active site
240015000424	I-site; other site
240015000425	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
240015000426	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
240015000427	hinge; other site
240015000428	active site
240015000429	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240015000430	GAF domain; Region: GAF_2; pfam13185
240015000431	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240015000432	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240015000433	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
240015000434	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
240015000435	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240015000436	active site
240015000437	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
240015000438	Protein of unknown function DUF45; Region: DUF45; cl00636
240015000439	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240015000440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000441	TPR motif; other site
240015000442	TPR repeat; Region: TPR_11; pfam13414
240015000443	binding surface
240015000444	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
240015000445	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000446	TPR motif; other site
240015000447	binding surface
240015000448	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000449	binding surface
240015000450	TPR motif; other site
240015000451	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000452	binding surface
240015000453	TPR motif; other site
240015000454	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
240015000455	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
240015000456	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
240015000457	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
240015000458	SET domain; Region: SET; pfam00856
240015000459	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240015000460	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000461	TPR motif; other site
240015000462	Cytochrome P450; Region: p450; cl12078
240015000463	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
240015000464	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
240015000465	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
240015000466	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
240015000467	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
240015000468	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
240015000469	homodimer interface [polypeptide binding]; other site
240015000470	metal binding site [ion binding]; metal-binding site
240015000471	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
240015000472	homodimer interface [polypeptide binding]; other site
240015000473	active site
240015000474	putative chemical substrate binding site [chemical binding]; other site
240015000475	metal binding site [ion binding]; metal-binding site
240015000476	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
240015000477	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
240015000478	active site
240015000479	octamer interface [polypeptide binding]; other site
240015000480	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
240015000481	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
240015000482	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240015000483	catalytic residue [active]
240015000484	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
240015000485	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
240015000486	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
240015000487	active site
240015000488	PAS domain; Region: PAS_9; pfam13426
240015000489	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015000490	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015000491	metal binding site [ion binding]; metal-binding site
240015000492	active site
240015000493	I-site; other site
240015000494	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240015000495	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
240015000496	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015000497	Walker A/P-loop; other site
240015000498	ATP binding site [chemical binding]; other site
240015000499	Q-loop/lid; other site
240015000500	ABC transporter signature motif; other site
240015000501	Walker B; other site
240015000502	D-loop; other site
240015000503	H-loop/switch region; other site
240015000504	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
240015000505	Permease; Region: Permease; pfam02405
240015000506	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
240015000507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015000508	active site
240015000509	phosphorylation site [posttranslational modification]
240015000510	intermolecular recognition site; other site
240015000511	dimerization interface [polypeptide binding]; other site
240015000512	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015000513	Walker A motif; other site
240015000514	ATP binding site [chemical binding]; other site
240015000515	Walker B motif; other site
240015000516	arginine finger; other site
240015000517	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
240015000518	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240015000519	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240015000520	GAF domain; Region: GAF_3; pfam13492
240015000521	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240015000522	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015000523	putative active site [active]
240015000524	heme pocket [chemical binding]; other site
240015000525	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015000526	dimer interface [polypeptide binding]; other site
240015000527	phosphorylation site [posttranslational modification]
240015000528	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015000529	ATP binding site [chemical binding]; other site
240015000530	Mg2+ binding site [ion binding]; other site
240015000531	G-X-G motif; other site
240015000532	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
240015000533	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240015000534	UDP-galactopyranose mutase; Region: GLF; pfam03275
240015000535	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
240015000536	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
240015000537	Probable Catalytic site; other site
240015000538	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240015000539	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240015000540	active site
240015000541	ATP binding site [chemical binding]; other site
240015000542	substrate binding site [chemical binding]; other site
240015000543	activation loop (A-loop); other site
240015000544	Predicted integral membrane protein [Function unknown]; Region: COG5616
240015000545	TPR repeat; Region: TPR_11; pfam13414
240015000546	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000547	binding surface
240015000548	TPR motif; other site
240015000549	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
240015000550	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000551	TPR motif; other site
240015000552	binding surface
240015000553	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000554	binding surface
240015000555	TPR motif; other site
240015000556	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000557	binding surface
240015000558	TPR motif; other site
240015000559	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
240015000560	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240015000561	ATP binding site [chemical binding]; other site
240015000562	putative Mg++ binding site [ion binding]; other site
240015000563	nucleotide binding region [chemical binding]; other site
240015000564	helicase superfamily c-terminal domain; Region: HELICc; smart00490
240015000565	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
240015000566	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
240015000567	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
240015000568	Transcriptional regulator PadR-like family; Region: PadR; cl17335
240015000569	PAS fold; Region: PAS_4; pfam08448
240015000570	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015000571	putative active site [active]
240015000572	heme pocket [chemical binding]; other site
240015000573	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015000574	PAS domain; Region: PAS_9; pfam13426
240015000575	putative active site [active]
240015000576	heme pocket [chemical binding]; other site
240015000577	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240015000578	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015000579	dimer interface [polypeptide binding]; other site
240015000580	phosphorylation site [posttranslational modification]
240015000581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015000582	ATP binding site [chemical binding]; other site
240015000583	Mg2+ binding site [ion binding]; other site
240015000584	G-X-G motif; other site
240015000585	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015000586	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015000587	Cupin; Region: Cupin_6; pfam12852
240015000588	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
240015000589	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240015000590	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240015000591	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
240015000592	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240015000593	putative NAD(P) binding site [chemical binding]; other site
240015000594	Cupin domain; Region: Cupin_2; pfam07883
240015000595	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
240015000596	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240015000597	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
240015000598	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
240015000599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015000600	D-galactonate transporter; Region: 2A0114; TIGR00893
240015000601	putative substrate translocation pore; other site
240015000602	putative dehydratase; Provisional; Region: PRK08211
240015000603	Dehydratase family; Region: ILVD_EDD; cl00340
240015000604	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
240015000605	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015000606	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
240015000607	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240015000608	putative NAD(P) binding site [chemical binding]; other site
240015000609	short chain dehydrogenase; Provisional; Region: PRK08263
240015000610	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
240015000611	NADP binding site [chemical binding]; other site
240015000612	active site
240015000613	steroid binding site; other site
240015000614	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
240015000615	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
240015000616	putative NAD(P) binding site [chemical binding]; other site
240015000617	putative substrate binding site [chemical binding]; other site
240015000618	catalytic Zn binding site [ion binding]; other site
240015000619	structural Zn binding site [ion binding]; other site
240015000620	dimer interface [polypeptide binding]; other site
240015000621	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
240015000622	Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cd10546
240015000623	putative active site [active]
240015000624	redox center [active]
240015000625	short chain dehydrogenase; Provisional; Region: PRK07109
240015000626	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
240015000627	putative NAD(P) binding site [chemical binding]; other site
240015000628	active site
240015000629	OsmC-like protein; Region: OsmC; pfam02566
240015000630	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
240015000631	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015000632	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015000633	metal binding site [ion binding]; metal-binding site
240015000634	active site
240015000635	I-site; other site
240015000636	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
240015000637	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
240015000638	catalytic triad [active]
240015000639	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
240015000640	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
240015000641	dimer interface [polypeptide binding]; other site
240015000642	active site
240015000643	heme binding site [chemical binding]; other site
240015000644	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
240015000645	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240015000646	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
240015000647	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
240015000648	dimerization interface [polypeptide binding]; other site
240015000649	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
240015000650	active site
240015000651	DNA polymerase IV; Validated; Region: PRK02406
240015000652	DNA binding site [nucleotide binding]
240015000653	iron donor protein CyaY; Region: FeS_CyaY; TIGR03421
240015000654	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
240015000655	Double zinc ribbon; Region: DZR; pfam12773
240015000656	PspC domain; Region: PspC; pfam04024
240015000657	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
240015000658	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
240015000659	diaminopimelate decarboxylase; Region: lysA; TIGR01048
240015000660	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
240015000661	active site
240015000662	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
240015000663	substrate binding site [chemical binding]; other site
240015000664	catalytic residues [active]
240015000665	dimer interface [polypeptide binding]; other site
240015000666	Carboxylesterase family; Region: COesterase; pfam00135
240015000667	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
240015000668	substrate binding pocket [chemical binding]; other site
240015000669	catalytic triad [active]
240015000670	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015000671	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
240015000672	Walker A/P-loop; other site
240015000673	ATP binding site [chemical binding]; other site
240015000674	Q-loop/lid; other site
240015000675	ABC transporter signature motif; other site
240015000676	Walker B; other site
240015000677	D-loop; other site
240015000678	H-loop/switch region; other site
240015000679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
240015000680	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240015000681	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
240015000682	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
240015000683	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
240015000684	DNA binding residues [nucleotide binding]
240015000685	molybdenum-pterin binding domain; Region: Mop; TIGR00638
240015000686	threonine synthase; Validated; Region: PRK06260
240015000687	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
240015000688	homodimer interface [polypeptide binding]; other site
240015000689	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015000690	catalytic residue [active]
240015000691	homoserine kinase; Provisional; Region: PRK01212
240015000692	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
240015000693	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240015000694	catalytic residues [active]
240015000695	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
240015000696	LexA repressor; Validated; Region: PRK00215
240015000697	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
240015000698	Catalytic site [active]
240015000699	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240015000700	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015000701	active site
240015000702	phosphorylation site [posttranslational modification]
240015000703	intermolecular recognition site; other site
240015000704	dimerization interface [polypeptide binding]; other site
240015000705	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240015000706	DNA binding site [nucleotide binding]
240015000707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015000708	phosphorylation site [posttranslational modification]
240015000709	intermolecular recognition site; other site
240015000710	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015000711	Walker A motif; other site
240015000712	ATP binding site [chemical binding]; other site
240015000713	Walker B motif; other site
240015000714	arginine finger; other site
240015000715	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
240015000716	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
240015000717	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
240015000718	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
240015000719	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
240015000720	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
240015000721	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
240015000722	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
240015000723	FliG C-terminal domain; Region: FliG_C; pfam01706
240015000724	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
240015000725	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
240015000726	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
240015000727	Walker A motif; other site
240015000728	ATP binding site [chemical binding]; other site
240015000729	Walker B motif; other site
240015000730	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
240015000731	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
240015000732	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
240015000733	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
240015000734	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
240015000735	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
240015000736	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
240015000737	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
240015000738	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
240015000739	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
240015000740	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
240015000741	FHIPEP family; Region: FHIPEP; pfam00771
240015000742	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015000743	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
240015000744	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240015000745	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015000746	DNA binding residues [nucleotide binding]
240015000747	flagellar motor switch protein FliN; Region: fliN; TIGR02480
240015000748	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
240015000749	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
240015000750	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
240015000751	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
240015000752	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
240015000753	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
240015000754	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
240015000755	Flagellar L-ring protein; Region: FlgH; cl17277
240015000756	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
240015000757	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
240015000758	flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541
240015000759	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
240015000760	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
240015000761	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
240015000762	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
240015000763	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
240015000764	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
240015000765	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
240015000766	MOFRL family; Region: MOFRL; pfam05161
240015000767	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
240015000768	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
240015000769	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like_fungal; cd05652
240015000770	metal binding site [ion binding]; metal-binding site
240015000771	putative dimer interface [polypeptide binding]; other site
240015000772	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
240015000773	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
240015000774	catalytic residues [active]
240015000775	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
240015000776	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
240015000777	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
240015000778	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
240015000779	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
240015000780	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240015000781	protein binding site [polypeptide binding]; other site
240015000782	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240015000783	protein binding site [polypeptide binding]; other site
240015000784	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
240015000785	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
240015000786	Right handed beta helix region; Region: Beta_helix; pfam13229
240015000787	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
240015000788	putative efflux protein, MATE family; Region: matE; TIGR00797
240015000789	cation binding site [ion binding]; other site
240015000790	Transcriptional regulator; Region: Rrf2; pfam02082
240015000791	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
240015000792	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
240015000793	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240015000794	putative active site [active]
240015000795	metal binding site [ion binding]; metal-binding site
240015000796	homodimer binding site [polypeptide binding]; other site
240015000797	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
240015000798	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
240015000799	dimer interface [polypeptide binding]; other site
240015000800	putative anticodon binding site; other site
240015000801	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
240015000802	motif 1; other site
240015000803	active site
240015000804	motif 2; other site
240015000805	motif 3; other site
240015000806	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
240015000807	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
240015000808	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
240015000809	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
240015000810	ATP synthase subunit C; Region: ATP-synt_C; cl00466
240015000811	NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007
240015000812	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240015000813	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
240015000814	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240015000815	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
240015000816	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
240015000817	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240015000818	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
240015000819	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
240015000820	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
240015000821	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
240015000822	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
240015000823	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240015000824	catalytic loop [active]
240015000825	iron binding site [ion binding]; other site
240015000826	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
240015000827	4Fe-4S binding domain; Region: Fer4; pfam00037
240015000828	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
240015000829	molybdopterin cofactor binding site; other site
240015000830	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
240015000831	SLBB domain; Region: SLBB; pfam10531
240015000832	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
240015000833	NADH dehydrogenase subunit E; Validated; Region: PRK07539
240015000834	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
240015000835	putative dimer interface [polypeptide binding]; other site
240015000836	[2Fe-2S] cluster binding site [ion binding]; other site
240015000837	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
240015000838	NADH dehydrogenase subunit D; Validated; Region: PRK06075
240015000839	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
240015000840	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
240015000841	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
240015000842	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
240015000843	putative dimer interface [polypeptide binding]; other site
240015000844	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240015000845	Helix-turn-helix domain; Region: HTH_18; pfam12833
240015000846	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240015000847	enolase; Provisional; Region: eno; PRK00077
240015000848	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
240015000849	dimer interface [polypeptide binding]; other site
240015000850	metal binding site [ion binding]; metal-binding site
240015000851	substrate binding pocket [chemical binding]; other site
240015000852	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
240015000853	phosphoglyceromutase; Provisional; Region: PRK05434
240015000854	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
240015000855	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015000856	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015000857	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240015000858	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
240015000859	putative homodimer interface [polypeptide binding]; other site
240015000860	putative homotetramer interface [polypeptide binding]; other site
240015000861	putative metal binding site [ion binding]; other site
240015000862	putative homodimer-homodimer interface [polypeptide binding]; other site
240015000863	putative allosteric switch controlling residues; other site
240015000864	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240015000865	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240015000866	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015000867	Walker A/P-loop; other site
240015000868	ATP binding site [chemical binding]; other site
240015000869	Q-loop/lid; other site
240015000870	ABC transporter signature motif; other site
240015000871	Walker B; other site
240015000872	D-loop; other site
240015000873	H-loop/switch region; other site
240015000874	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
240015000875	AAA domain; Region: AAA_33; pfam13671
240015000876	ATP-binding site [chemical binding]; other site
240015000877	Gluconate-6-phosphate binding site [chemical binding]; other site
240015000878	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
240015000879	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
240015000880	Flagellin N-methylase; Region: FliB; cl00497
240015000881	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
240015000882	fumarylacetoacetase; Region: PLN02856
240015000883	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
240015000884	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
240015000885	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
240015000886	DNA binding site [nucleotide binding]
240015000887	Transcriptional regulators [Transcription]; Region: PurR; COG1609
240015000888	domain linker motif; other site
240015000889	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
240015000890	dimerization interface [polypeptide binding]; other site
240015000891	ligand binding site [chemical binding]; other site
240015000892	homoserine dehydrogenase; Provisional; Region: PRK06349
240015000893	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
240015000894	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
240015000895	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
240015000896	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240015000897	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240015000898	active site
240015000899	catalytic tetrad [active]
240015000900	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
240015000901	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
240015000902	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
240015000903	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
240015000904	[4Fe-4S] binding site [ion binding]; other site
240015000905	molybdopterin cofactor binding site; other site
240015000906	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
240015000907	molybdopterin cofactor binding site; other site
240015000908	Transcriptional regulators [Transcription]; Region: PurR; COG1609
240015000909	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
240015000910	DNA binding site [nucleotide binding]
240015000911	domain linker motif; other site
240015000912	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
240015000913	ligand binding site [chemical binding]; other site
240015000914	dimerization interface [polypeptide binding]; other site
240015000915	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
240015000916	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
240015000917	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
240015000918	inhibitor site; inhibition site
240015000919	active site
240015000920	dimer interface [polypeptide binding]; other site
240015000921	catalytic residue [active]
240015000922	Class I aldolases; Region: Aldolase_Class_I; cl17187
240015000923	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
240015000924	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
240015000925	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
240015000926	dimer interface [polypeptide binding]; other site
240015000927	PYR/PP interface [polypeptide binding]; other site
240015000928	TPP binding site [chemical binding]; other site
240015000929	substrate binding site [chemical binding]; other site
240015000930	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
240015000931	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
240015000932	TPP-binding site [chemical binding]; other site
240015000933	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
240015000934	Domain of unknown function (DUF303); Region: DUF303; pfam03629
240015000935	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
240015000936	catalytic motif [active]
240015000937	Catalytic residue [active]
240015000938	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
240015000939	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240015000940	active site
240015000941	ATP binding site [chemical binding]; other site
240015000942	substrate binding site [chemical binding]; other site
240015000943	activation loop (A-loop); other site
240015000944	Predicted integral membrane protein [Function unknown]; Region: COG5616
240015000945	TPR repeat; Region: TPR_11; pfam13414
240015000946	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000947	TPR motif; other site
240015000948	binding surface
240015000949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000950	TPR motif; other site
240015000951	binding surface
240015000952	TPR repeat; Region: TPR_11; pfam13414
240015000953	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015000954	TPR motif; other site
240015000955	binding surface
240015000956	TPR repeat; Region: TPR_11; pfam13414
240015000957	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
240015000958	thiS-thiF/thiG interaction site; other site
240015000959	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
240015000960	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240015000961	dimer interface [polypeptide binding]; other site
240015000962	conserved gate region; other site
240015000963	putative PBP binding loops; other site
240015000964	ABC-ATPase subunit interface; other site
240015000965	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
240015000966	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
240015000967	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
240015000968	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
240015000969	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
240015000970	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240015000971	Transposase IS200 like; Region: Y1_Tnp; cl00848
240015000972	Homeodomain-like domain; Region: HTH_23; cl17451
240015000973	Integrase core domain; Region: rve; pfam00665
240015000974	Integrase core domain; Region: rve_3; pfam13683
240015000975	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
240015000976	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
240015000977	FAD binding domain; Region: FAD_binding_4; pfam01565
240015000978	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
240015000979	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270
240015000980	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
240015000981	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240015000982	ABC transporter; Region: ABC_tran_2; pfam12848
240015000983	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240015000984	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
240015000985	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015000986	Walker A/P-loop; other site
240015000987	ATP binding site [chemical binding]; other site
240015000988	Q-loop/lid; other site
240015000989	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240015000990	ABC transporter signature motif; other site
240015000991	Walker B; other site
240015000992	D-loop; other site
240015000993	ABC transporter; Region: ABC_tran_2; pfam12848
240015000994	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240015000995	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
240015000996	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240015000997	G1 box; other site
240015000998	GTP/Mg2+ binding site [chemical binding]; other site
240015000999	G2 box; other site
240015001000	Switch I region; other site
240015001001	G3 box; other site
240015001002	Switch II region; other site
240015001003	G4 box; other site
240015001004	G5 box; other site
240015001005	Nucleoside recognition; Region: Gate; pfam07670
240015001006	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
240015001007	Nucleoside recognition; Region: Gate; pfam07670
240015001008	FeoA domain; Region: FeoA; pfam04023
240015001009	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
240015001010	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
240015001011	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
240015001012	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
240015001013	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
240015001014	dimer interface [polypeptide binding]; other site
240015001015	TPP-binding site [chemical binding]; other site
240015001016	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
240015001017	potential protein location (hypothetical protein) that overlaps protein (dehydrogenase E1 component domain protein)
240015001018	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
240015001019	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
240015001020	heterotetramer interface [polypeptide binding]; other site
240015001021	active site pocket [active]
240015001022	cleavage site
240015001023	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
240015001024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015001025	Walker A/P-loop; other site
240015001026	ATP binding site [chemical binding]; other site
240015001027	Q-loop/lid; other site
240015001028	ABC transporter signature motif; other site
240015001029	Walker B; other site
240015001030	D-loop; other site
240015001031	H-loop/switch region; other site
240015001032	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
240015001033	translocation protein TolB; Provisional; Region: tolB; PRK01742
240015001034	AAA ATPase domain; Region: AAA_16; pfam13191
240015001035	AAA domain; Region: AAA_22; pfam13401
240015001036	Winged helix-turn helix; Region: HTH_29; pfam13551
240015001037	Helix-turn-helix domain; Region: HTH_28; pfam13518
240015001038	Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039
240015001039	Integrase core domain; Region: rve; pfam00665
240015001040	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015001041	non-specific DNA binding site [nucleotide binding]; other site
240015001042	salt bridge; other site
240015001043	sequence-specific DNA binding site [nucleotide binding]; other site
240015001044	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
240015001045	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
240015001046	Terminase-like family; Region: Terminase_6; pfam03237
240015001047	Protein of unknown function (DUF935); Region: DUF935; pfam06074
240015001048	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
240015001049	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
240015001050	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
240015001051	Domain of unknown function (DUF1834); Region: DUF1834; cl02087
240015001052	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
240015001053	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
240015001054	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
240015001055	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
240015001056	dimerization interface [polypeptide binding]; other site
240015001057	active site
240015001058	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
240015001059	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015001060	motif II; other site
240015001061	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
240015001062	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240015001063	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015001064	homodimer interface [polypeptide binding]; other site
240015001065	catalytic residue [active]
240015001066	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
240015001067	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
240015001068	Transcriptional regulators [Transcription]; Region: PurR; COG1609
240015001069	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
240015001070	DNA binding site [nucleotide binding]
240015001071	domain linker motif; other site
240015001072	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
240015001073	dimerization interface [polypeptide binding]; other site
240015001074	ligand binding site [chemical binding]; other site
240015001075	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240015001076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015001077	active site
240015001078	phosphorylation site [posttranslational modification]
240015001079	intermolecular recognition site; other site
240015001080	dimerization interface [polypeptide binding]; other site
240015001081	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240015001082	DNA binding site [nucleotide binding]
240015001083	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
240015001084	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
240015001085	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240015001086	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240015001087	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
240015001088	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
240015001089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015001090	putative substrate translocation pore; other site
240015001091	Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486
240015001092	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
240015001093	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
240015001094	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
240015001095	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015001096	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015001097	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
240015001098	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
240015001099	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
240015001100	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
240015001101	NADP binding site [chemical binding]; other site
240015001102	active site
240015001103	steroid binding site; other site
240015001104	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
240015001105	putative FMN binding site [chemical binding]; other site
240015001106	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
240015001107	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
240015001108	NADP binding site [chemical binding]; other site
240015001109	dimer interface [polypeptide binding]; other site
240015001110	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240015001111	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240015001112	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
240015001113	classical (c) SDRs; Region: SDR_c; cd05233
240015001114	NAD(P) binding site [chemical binding]; other site
240015001115	active site
240015001116	Nitronate monooxygenase; Region: NMO; pfam03060
240015001117	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
240015001118	FMN binding site [chemical binding]; other site
240015001119	substrate binding site [chemical binding]; other site
240015001120	putative catalytic residue [active]
240015001121	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015001122	PAS fold; Region: PAS_3; pfam08447
240015001123	putative active site [active]
240015001124	heme pocket [chemical binding]; other site
240015001125	PAS domain S-box; Region: sensory_box; TIGR00229
240015001126	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015001127	putative active site [active]
240015001128	heme pocket [chemical binding]; other site
240015001129	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015001130	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240015001131	putative active site [active]
240015001132	heme pocket [chemical binding]; other site
240015001133	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015001134	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240015001135	putative active site [active]
240015001136	heme pocket [chemical binding]; other site
240015001137	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015001138	putative active site [active]
240015001139	heme pocket [chemical binding]; other site
240015001140	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240015001141	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015001142	dimer interface [polypeptide binding]; other site
240015001143	phosphorylation site [posttranslational modification]
240015001144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015001145	ATP binding site [chemical binding]; other site
240015001146	Mg2+ binding site [ion binding]; other site
240015001147	G-X-G motif; other site
240015001148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015001149	Response regulator receiver domain; Region: Response_reg; pfam00072
240015001150	active site
240015001151	phosphorylation site [posttranslational modification]
240015001152	intermolecular recognition site; other site
240015001153	dimerization interface [polypeptide binding]; other site
240015001154	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
240015001155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015001156	active site
240015001157	phosphorylation site [posttranslational modification]
240015001158	intermolecular recognition site; other site
240015001159	dimerization interface [polypeptide binding]; other site
240015001160	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015001161	DNA binding residues [nucleotide binding]
240015001162	dimerization interface [polypeptide binding]; other site
240015001163	putative transposase OrfB; Reviewed; Region: PHA02517
240015001164	HTH-like domain; Region: HTH_21; pfam13276
240015001165	Integrase core domain; Region: rve; pfam00665
240015001166	Integrase core domain; Region: rve_3; pfam13683
240015001167	Transposase; Region: HTH_Tnp_1; cl17663
240015001168	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
240015001169	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
240015001170	protein translocase, SecG subunit; Region: secG; TIGR00810
240015001171	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015001172	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015001173	metal binding site [ion binding]; metal-binding site
240015001174	active site
240015001175	I-site; other site
240015001176	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
240015001177	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
240015001178	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
240015001179	predicted active site [active]
240015001180	catalytic triad [active]
240015001181	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
240015001182	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
240015001183	active site
240015001184	multimer interface [polypeptide binding]; other site
240015001185	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
240015001186	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
240015001187	Cl- selectivity filter; other site
240015001188	Cl- binding residues [ion binding]; other site
240015001189	pore gating glutamate residue; other site
240015001190	dimer interface [polypeptide binding]; other site
240015001191	TrkA-C domain; Region: TrkA_C; pfam02080
240015001192	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
240015001193	CoenzymeA binding site [chemical binding]; other site
240015001194	subunit interaction site [polypeptide binding]; other site
240015001195	PHB binding site; other site
240015001196	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015001197	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015001198	metal binding site [ion binding]; metal-binding site
240015001199	active site
240015001200	I-site; other site
240015001201	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
240015001202	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
240015001203	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015001204	FeS/SAM binding site; other site
240015001205	TRAM domain; Region: TRAM; pfam01938
240015001206	Bifunctional nuclease; Region: DNase-RNase; pfam02577
240015001207	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240015001208	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240015001209	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
240015001210	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
240015001211	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
240015001212	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240015001213	Ligand Binding Site [chemical binding]; other site
240015001214	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240015001215	Ligand Binding Site [chemical binding]; other site
240015001216	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240015001217	Ligand Binding Site [chemical binding]; other site
240015001218	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240015001219	Ligand Binding Site [chemical binding]; other site
240015001220	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240015001221	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240015001222	ligand binding site [chemical binding]; other site
240015001223	flexible hinge region; other site
240015001224	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
240015001225	putative switch regulator; other site
240015001226	non-specific DNA interactions [nucleotide binding]; other site
240015001227	DNA binding site [nucleotide binding]
240015001228	sequence specific DNA binding site [nucleotide binding]; other site
240015001229	putative cAMP binding site [chemical binding]; other site
240015001230	PAS domain S-box; Region: sensory_box; TIGR00229
240015001231	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015001232	putative active site [active]
240015001233	heme pocket [chemical binding]; other site
240015001234	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015001235	PAS domain; Region: PAS_9; pfam13426
240015001236	putative active site [active]
240015001237	heme pocket [chemical binding]; other site
240015001238	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240015001239	GAF domain; Region: GAF; pfam01590
240015001240	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015001241	Walker A motif; other site
240015001242	ATP binding site [chemical binding]; other site
240015001243	Walker B motif; other site
240015001244	arginine finger; other site
240015001245	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
240015001246	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
240015001247	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
240015001248	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
240015001249	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
240015001250	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
240015001251	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
240015001252	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
240015001253	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240015001254	Ligand Binding Site [chemical binding]; other site
240015001255	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
240015001256	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
240015001257	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
240015001258	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
240015001259	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
240015001260	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
240015001261	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
240015001262	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
240015001263	active site residue [active]
240015001264	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
240015001265	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240015001266	catalytic residues [active]
240015001267	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
240015001268	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015001269	S-adenosylmethionine binding site [chemical binding]; other site
240015001270	BNR repeat-like domain; Region: BNR_2; pfam13088
240015001271	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
240015001272	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
240015001273	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
240015001274	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
240015001275	active site
240015001276	HIGH motif; other site
240015001277	nucleotide binding site [chemical binding]; other site
240015001278	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
240015001279	active site
240015001280	KMSKS motif; other site
240015001281	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
240015001282	tRNA binding surface [nucleotide binding]; other site
240015001283	anticodon binding site; other site
240015001284	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
240015001285	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
240015001286	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
240015001287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015001288	Walker A motif; other site
240015001289	ATP binding site [chemical binding]; other site
240015001290	Walker B motif; other site
240015001291	arginine finger; other site
240015001292	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
240015001293	hypothetical protein; Validated; Region: PRK00153
240015001294	Response regulator receiver domain; Region: Response_reg; pfam00072
240015001295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015001296	active site
240015001297	phosphorylation site [posttranslational modification]
240015001298	intermolecular recognition site; other site
240015001299	dimerization interface [polypeptide binding]; other site
240015001300	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
240015001301	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
240015001302	Walker A/P-loop; other site
240015001303	ATP binding site [chemical binding]; other site
240015001304	Q-loop/lid; other site
240015001305	ABC transporter signature motif; other site
240015001306	Walker B; other site
240015001307	D-loop; other site
240015001308	H-loop/switch region; other site
240015001309	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
240015001310	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
240015001311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240015001312	dimer interface [polypeptide binding]; other site
240015001313	conserved gate region; other site
240015001314	putative PBP binding loops; other site
240015001315	ABC-ATPase subunit interface; other site
240015001316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240015001317	dimer interface [polypeptide binding]; other site
240015001318	ABC-ATPase subunit interface; other site
240015001319	putative PBP binding loops; other site
240015001320	CHASE3 domain; Region: CHASE3; pfam05227
240015001321	GAF domain; Region: GAF_3; pfam13492
240015001322	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015001323	dimer interface [polypeptide binding]; other site
240015001324	phosphorylation site [posttranslational modification]
240015001325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015001326	ATP binding site [chemical binding]; other site
240015001327	Mg2+ binding site [ion binding]; other site
240015001328	G-X-G motif; other site
240015001329	Response regulator receiver domain; Region: Response_reg; pfam00072
240015001330	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015001331	active site
240015001332	phosphorylation site [posttranslational modification]
240015001333	intermolecular recognition site; other site
240015001334	dimerization interface [polypeptide binding]; other site
240015001335	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240015001336	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015001337	active site
240015001338	phosphorylation site [posttranslational modification]
240015001339	intermolecular recognition site; other site
240015001340	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
240015001341	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015001342	putative active site [active]
240015001343	heme pocket [chemical binding]; other site
240015001344	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015001345	phosphorylation site [posttranslational modification]
240015001346	dimer interface [polypeptide binding]; other site
240015001347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015001348	ATP binding site [chemical binding]; other site
240015001349	Mg2+ binding site [ion binding]; other site
240015001350	G-X-G motif; other site
240015001351	putative oxidoreductase; Provisional; Region: PRK11579
240015001352	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240015001353	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
240015001354	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
240015001355	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
240015001356	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
240015001357	ligand binding site [chemical binding]; other site
240015001358	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
240015001359	TolB amino-terminal domain; Region: TolB_N; pfam04052
240015001360	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
240015001361	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
240015001362	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
240015001363	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
240015001364	TonB C terminal; Region: TonB_2; pfam13103
240015001365	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
240015001366	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
240015001367	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
240015001368	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
240015001369	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
240015001370	Walker A/P-loop; other site
240015001371	ATP binding site [chemical binding]; other site
240015001372	Q-loop/lid; other site
240015001373	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
240015001374	ABC transporter signature motif; other site
240015001375	Walker B; other site
240015001376	D-loop; other site
240015001377	H-loop/switch region; other site
240015001378	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
240015001379	recombination protein RecR; Reviewed; Region: recR; PRK00076
240015001380	RecR protein; Region: RecR; pfam02132
240015001381	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
240015001382	putative active site [active]
240015001383	putative metal-binding site [ion binding]; other site
240015001384	tetramer interface [polypeptide binding]; other site
240015001385	Phospholipase B; Region: Phospholip_B; pfam04916
240015001386	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
240015001387	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
240015001388	active site
240015001389	NTP binding site [chemical binding]; other site
240015001390	metal binding triad [ion binding]; metal-binding site
240015001391	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
240015001392	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
240015001393	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
240015001394	trimer interface [polypeptide binding]; other site
240015001395	active site
240015001396	UDP-GlcNAc binding site [chemical binding]; other site
240015001397	lipid binding site [chemical binding]; lipid-binding site
240015001398	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
240015001399	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240015001400	active site
240015001401	phosphorylation site [posttranslational modification]
240015001402	intermolecular recognition site; other site
240015001403	dimerization interface [polypeptide binding]; other site
240015001404	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
240015001405	PAS domain; Region: PAS_9; pfam13426
240015001406	putative active site [active]
240015001407	heme pocket [chemical binding]; other site
240015001408	MASE1; Region: MASE1; cl17823
240015001409	PAS domain S-box; Region: sensory_box; TIGR00229
240015001410	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015001411	putative active site [active]
240015001412	heme pocket [chemical binding]; other site
240015001413	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015001414	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015001415	metal binding site [ion binding]; metal-binding site
240015001416	active site
240015001417	I-site; other site
240015001418	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
240015001419	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
240015001420	Formiminotransferase domain; Region: FTCD; pfam02971
240015001421	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
240015001422	hypothetical protein; Validated; Region: PRK00110
240015001423	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240015001424	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240015001425	active site
240015001426	catalytic tetrad [active]
240015001427	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015001428	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015001429	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015001430	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
240015001431	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
240015001432	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
240015001433	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
240015001434	glycogen synthase; Provisional; Region: glgA; PRK00654
240015001435	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
240015001436	ADP-binding pocket [chemical binding]; other site
240015001437	homodimer interface [polypeptide binding]; other site
240015001438	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
240015001439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015001440	S-adenosylmethionine binding site [chemical binding]; other site
240015001441	FecR protein; Region: FecR; pfam04773
240015001442	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
240015001443	active site
240015001444	putative DNA-binding cleft [nucleotide binding]; other site
240015001445	dimer interface [polypeptide binding]; other site
240015001446	Cytochrome c [Energy production and conversion]; Region: COG3258
240015001447	Cytochrome c; Region: Cytochrom_C; pfam00034
240015001448	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
240015001449	ThiS interaction site; other site
240015001450	putative active site [active]
240015001451	tetramer interface [polypeptide binding]; other site
240015001452	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
240015001453	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015001454	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
240015001455	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
240015001456	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
240015001457	Amidase; Region: Amidase; cl11426
240015001458	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
240015001459	DNA-binding site [nucleotide binding]; DNA binding site
240015001460	RNA-binding motif; other site
240015001461	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
240015001462	active site
240015001463	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
240015001464	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
240015001465	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
240015001466	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
240015001467	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015001468	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
240015001469	active site
240015001470	catalytic triad [active]
240015001471	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
240015001472	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
240015001473	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
240015001474	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
240015001475	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
240015001476	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
240015001477	rhamnose-proton symporter; Provisional; Region: PRK13499
240015001478	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
240015001479	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
240015001480	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
240015001481	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
240015001482	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
240015001483	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
240015001484	ligand binding site [chemical binding]; other site
240015001485	short chain dehydrogenase; Validated; Region: PRK08324
240015001486	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
240015001487	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015001488	NAD(P) binding site [chemical binding]; other site
240015001489	active site
240015001490	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
240015001491	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
240015001492	N- and C-terminal domain interface [polypeptide binding]; other site
240015001493	active site
240015001494	putative catalytic site [active]
240015001495	metal binding site [ion binding]; metal-binding site
240015001496	ATP binding site [chemical binding]; other site
240015001497	carbohydrate binding site [chemical binding]; other site
240015001498	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
240015001499	active site
240015001500	catalytic triad [active]
240015001501	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015001502	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015001503	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240015001504	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
240015001505	Peptidase family M48; Region: Peptidase_M48; pfam01435
240015001506	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015001507	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015001508	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
240015001509	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
240015001510	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
240015001511	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501
240015001512	active site
240015001513	catalytic triad [active]
240015001514	oxyanion hole [active]
240015001515	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
240015001516	Glyco_18 domain; Region: Glyco_18; smart00636
240015001517	active site
240015001518	BON domain; Region: BON; pfam04972
240015001519	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
240015001520	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
240015001521	PYR/PP interface [polypeptide binding]; other site
240015001522	dimer interface [polypeptide binding]; other site
240015001523	TPP binding site [chemical binding]; other site
240015001524	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
240015001525	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
240015001526	TPP-binding site [chemical binding]; other site
240015001527	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015001528	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240015001529	NAD(P) binding site [chemical binding]; other site
240015001530	active site
240015001531	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
240015001532	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
240015001533	NAD binding site [chemical binding]; other site
240015001534	homotetramer interface [polypeptide binding]; other site
240015001535	homodimer interface [polypeptide binding]; other site
240015001536	substrate binding site [chemical binding]; other site
240015001537	active site
240015001538	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
240015001539	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
240015001540	substrate binding site; other site
240015001541	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
240015001542	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
240015001543	Ligand binding site; other site
240015001544	Putative Catalytic site; other site
240015001545	DXD motif; other site
240015001546	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
240015001547	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
240015001548	inhibitor-cofactor binding pocket; inhibition site
240015001549	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015001550	catalytic residue [active]
240015001551	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
240015001552	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240015001553	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240015001554	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240015001555	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
240015001556	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240015001557	active site
240015001558	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
240015001559	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
240015001560	putative NAD(P) binding site [chemical binding]; other site
240015001561	putative substrate binding site [chemical binding]; other site
240015001562	catalytic Zn binding site [ion binding]; other site
240015001563	structural Zn binding site [ion binding]; other site
240015001564	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
240015001565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015001566	S-adenosylmethionine binding site [chemical binding]; other site
240015001567	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
240015001568	DinB superfamily; Region: DinB_2; pfam12867
240015001569	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
240015001570	DALR anticodon binding domain; Region: DALR_1; pfam05746
240015001571	anticodon binding site; other site
240015001572	tRNA binding surface [nucleotide binding]; other site
240015001573	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
240015001574	motif 1; other site
240015001575	dimer interface [polypeptide binding]; other site
240015001576	active site
240015001577	motif 2; other site
240015001578	motif 3; other site
240015001579	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
240015001580	Recombination protein O N terminal; Region: RecO_N; pfam11967
240015001581	Recombination protein O C terminal; Region: RecO_C; pfam02565
240015001582	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
240015001583	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
240015001584	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
240015001585	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
240015001586	putative active site [active]
240015001587	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
240015001588	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
240015001589	ATP binding site [chemical binding]; other site
240015001590	substrate interface [chemical binding]; other site
240015001591	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
240015001592	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
240015001593	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
240015001594	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
240015001595	Surface antigen; Region: Bac_surface_Ag; pfam01103
240015001596	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
240015001597	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
240015001598	Family of unknown function (DUF490); Region: DUF490; pfam04357
240015001599	BON domain; Region: BON; pfam04972
240015001600	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
240015001601	BON domain; Region: BON; pfam04972
240015001602	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
240015001603	UbiA prenyltransferase family; Region: UbiA; pfam01040
240015001604	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
240015001605	Prephenate dehydratase; Region: PDT; pfam00800
240015001606	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
240015001607	putative L-Phe binding site [chemical binding]; other site
240015001608	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
240015001609	Found in ATP-dependent protease La (LON); Region: LON; smart00464
240015001610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015001611	Walker A motif; other site
240015001612	ATP binding site [chemical binding]; other site
240015001613	Walker B motif; other site
240015001614	arginine finger; other site
240015001615	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
240015001616	primosomal protein N' Region: priA; TIGR00595
240015001617	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240015001618	ATP binding site [chemical binding]; other site
240015001619	putative Mg++ binding site [ion binding]; other site
240015001620	helicase superfamily c-terminal domain; Region: HELICc; smart00490
240015001621	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
240015001622	Fe-S cluster binding site [ion binding]; other site
240015001623	active site
240015001624	Flavoprotein; Region: Flavoprotein; pfam02441
240015001625	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
240015001626	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
240015001627	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
240015001628	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
240015001629	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
240015001630	catalytic site [active]
240015001631	G-X2-G-X-G-K; other site
240015001632	hypothetical protein; Provisional; Region: PRK11820
240015001633	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
240015001634	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
240015001635	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240015001636	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240015001637	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
240015001638	Walker A/P-loop; other site
240015001639	ATP binding site [chemical binding]; other site
240015001640	Q-loop/lid; other site
240015001641	ABC transporter signature motif; other site
240015001642	Walker B; other site
240015001643	D-loop; other site
240015001644	H-loop/switch region; other site
240015001645	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
240015001646	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
240015001647	30S subunit binding site; other site
240015001648	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
240015001649	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
240015001650	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
240015001651	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
240015001652	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
240015001653	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
240015001654	Walker A/P-loop; other site
240015001655	ATP binding site [chemical binding]; other site
240015001656	Q-loop/lid; other site
240015001657	ABC transporter signature motif; other site
240015001658	Walker B; other site
240015001659	D-loop; other site
240015001660	H-loop/switch region; other site
240015001661	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
240015001662	OstA-like protein; Region: OstA; cl00844
240015001663	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
240015001664	OstA-like protein; Region: OstA; cl00844
240015001665	DinB superfamily; Region: DinB_2; pfam12867
240015001666	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
240015001667	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240015001668	dimer interface [polypeptide binding]; other site
240015001669	conserved gate region; other site
240015001670	ABC-ATPase subunit interface; other site
240015001671	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015001672	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
240015001673	Walker A/P-loop; other site
240015001674	ATP binding site [chemical binding]; other site
240015001675	Q-loop/lid; other site
240015001676	ABC transporter signature motif; other site
240015001677	Walker B; other site
240015001678	D-loop; other site
240015001679	H-loop/switch region; other site
240015001680	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
240015001681	AAA domain; Region: AAA_33; pfam13671
240015001682	L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575
240015001683	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
240015001684	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
240015001685	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
240015001686	Phosphoglycerate kinase; Region: PGK; pfam00162
240015001687	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
240015001688	substrate binding site [chemical binding]; other site
240015001689	hinge regions; other site
240015001690	ADP binding site [chemical binding]; other site
240015001691	catalytic site [active]
240015001692	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
240015001693	Protein of unknown function (DUF497); Region: DUF497; pfam04365
240015001694	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
240015001695	triosephosphate isomerase; Provisional; Region: PRK14565
240015001696	substrate binding site [chemical binding]; other site
240015001697	dimer interface [polypeptide binding]; other site
240015001698	catalytic triad [active]
240015001699	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
240015001700	active site
240015001701	metal binding site [ion binding]; metal-binding site
240015001702	homotetramer interface [polypeptide binding]; other site
240015001703	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
240015001704	Domain of unknown function DUF21; Region: DUF21; pfam01595
240015001705	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
240015001706	Transporter associated domain; Region: CorC_HlyC; smart01091
240015001707	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
240015001708	Fasciclin domain; Region: Fasciclin; pfam02469
240015001709	RNA polymerase sigma factor; Provisional; Region: PRK12519
240015001710	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015001711	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015001712	DNA binding residues [nucleotide binding]
240015001713	putative anti-sigmaE protein; Provisional; Region: PRK13920
240015001714	Putative zinc-finger; Region: zf-HC2; pfam13490
240015001715	Anti-sigma-K factor rskA; Region: RskA; pfam10099
240015001716	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
240015001717	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
240015001718	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240015001719	ATP binding site [chemical binding]; other site
240015001720	putative Mg++ binding site [ion binding]; other site
240015001721	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240015001722	nucleotide binding region [chemical binding]; other site
240015001723	ATP-binding site [chemical binding]; other site
240015001724	HRDC domain; Region: HRDC; pfam00570
240015001725	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240015001726	active site
240015001727	catalytic residues [active]
240015001728	DNA binding site [nucleotide binding]
240015001729	Int/Topo IB signature motif; other site
240015001730	AAA domain; Region: AAA_13; pfam13166
240015001731	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
240015001732	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
240015001733	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535
240015001734	metal binding site [ion binding]; metal-binding site
240015001735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015001736	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
240015001737	Walker A motif; other site
240015001738	ATP binding site [chemical binding]; other site
240015001739	Walker B motif; other site
240015001740	arginine finger; other site
240015001741	TIR domain; Region: TIR_2; pfam13676
240015001742	Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659
240015001743	5' RNA guide strand anchoring site; other site
240015001744	active site
240015001745	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015001746	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015001747	metal binding site [ion binding]; metal-binding site
240015001748	active site
240015001749	I-site; other site
240015001750	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240015001751	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240015001752	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240015001753	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
240015001754	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015001755	sequence-specific DNA binding site [nucleotide binding]; other site
240015001756	salt bridge; other site
240015001757	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
240015001758	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015001759	non-specific DNA binding site [nucleotide binding]; other site
240015001760	salt bridge; other site
240015001761	sequence-specific DNA binding site [nucleotide binding]; other site
240015001762	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
240015001763	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
240015001764	conserved cys residue [active]
240015001765	short chain dehydrogenase; Provisional; Region: PRK06500
240015001766	classical (c) SDRs; Region: SDR_c; cd05233
240015001767	NAD(P) binding site [chemical binding]; other site
240015001768	active site
240015001769	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
240015001770	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
240015001771	conserved cys residue [active]
240015001772	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240015001773	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
240015001774	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
240015001775	Thioredoxin; Region: Thioredoxin_4; pfam13462
240015001776	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
240015001777	NAD synthetase; Provisional; Region: PRK13981
240015001778	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
240015001779	multimer interface [polypeptide binding]; other site
240015001780	active site
240015001781	catalytic triad [active]
240015001782	protein interface 1 [polypeptide binding]; other site
240015001783	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
240015001784	homodimer interface [polypeptide binding]; other site
240015001785	NAD binding pocket [chemical binding]; other site
240015001786	ATP binding pocket [chemical binding]; other site
240015001787	Mg binding site [ion binding]; other site
240015001788	active-site loop [active]
240015001789	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
240015001790	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
240015001791	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
240015001792	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
240015001793	Multicopper oxidase; Region: Cu-oxidase; pfam00394
240015001794	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
240015001795	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
240015001796	active site residue [active]
240015001797	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
240015001798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015001799	active site
240015001800	phosphorylation site [posttranslational modification]
240015001801	intermolecular recognition site; other site
240015001802	dimerization interface [polypeptide binding]; other site
240015001803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015001804	Walker A motif; other site
240015001805	ATP binding site [chemical binding]; other site
240015001806	Walker B motif; other site
240015001807	KicB killing factor; Region: KicB; cl11468
240015001808	arginine finger; other site
240015001809	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
240015001810	PAS domain; Region: PAS; smart00091
240015001811	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
240015001812	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015001813	dimer interface [polypeptide binding]; other site
240015001814	phosphorylation site [posttranslational modification]
240015001815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015001816	ATP binding site [chemical binding]; other site
240015001817	Mg2+ binding site [ion binding]; other site
240015001818	G-X-G motif; other site
240015001819	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
240015001820	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
240015001821	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
240015001822	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240015001823	RNA binding surface [nucleotide binding]; other site
240015001824	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
240015001825	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
240015001826	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
240015001827	nucleotide binding site [chemical binding]; other site
240015001828	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
240015001829	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
240015001830	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
240015001831	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
240015001832	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
240015001833	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
240015001834	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240015001835	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
240015001836	IMP binding site; other site
240015001837	dimer interface [polypeptide binding]; other site
240015001838	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
240015001839	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
240015001840	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
240015001841	catalytic site [active]
240015001842	subunit interface [polypeptide binding]; other site
240015001843	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
240015001844	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
240015001845	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
240015001846	dimerization interface 3.5A [polypeptide binding]; other site
240015001847	active site
240015001848	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
240015001849	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
240015001850	putative metal binding site [ion binding]; other site
240015001851	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
240015001852	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015001853	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
240015001854	NAD(P) binding site [chemical binding]; other site
240015001855	active site
240015001856	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
240015001857	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
240015001858	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
240015001859	Ligand binding site; other site
240015001860	Putative Catalytic site; other site
240015001861	DXD motif; other site
240015001862	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
240015001863	Walker A/P-loop; other site
240015001864	ATP binding site [chemical binding]; other site
240015001865	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015001866	Q-loop/lid; other site
240015001867	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
240015001868	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
240015001869	ABC transporter signature motif; other site
240015001870	Walker B; other site
240015001871	D-loop; other site
240015001872	H-loop/switch region; other site
240015001873	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
240015001874	ATP binding site [chemical binding]; other site
240015001875	active site
240015001876	substrate binding site [chemical binding]; other site
240015001877	Colicin V production protein; Region: Colicin_V; pfam02674
240015001878	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
240015001879	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
240015001880	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015001881	motif II; other site
240015001882	TPR repeat; Region: TPR_11; pfam13414
240015001883	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015001884	binding surface
240015001885	TPR motif; other site
240015001886	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
240015001887	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
240015001888	active site
240015001889	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240015001890	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
240015001891	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015001892	ATP binding site [chemical binding]; other site
240015001893	Mg2+ binding site [ion binding]; other site
240015001894	G-X-G motif; other site
240015001895	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015001896	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015001897	active site
240015001898	phosphorylation site [posttranslational modification]
240015001899	intermolecular recognition site; other site
240015001900	dimerization interface [polypeptide binding]; other site
240015001901	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015001902	DNA binding residues [nucleotide binding]
240015001903	dimerization interface [polypeptide binding]; other site
240015001904	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994
240015001905	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
240015001906	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
240015001907	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
240015001908	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
240015001909	minor groove reading motif; other site
240015001910	helix-hairpin-helix signature motif; other site
240015001911	substrate binding pocket [chemical binding]; other site
240015001912	active site
240015001913	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
240015001914	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
240015001915	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
240015001916	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
240015001917	active site
240015001918	catalytic site [active]
240015001919	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
240015001920	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
240015001921	active site
240015001922	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
240015001923	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
240015001924	domain interfaces; other site
240015001925	active site
240015001926	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
240015001927	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
240015001928	tRNA; other site
240015001929	putative tRNA binding site [nucleotide binding]; other site
240015001930	putative NADP binding site [chemical binding]; other site
240015001931	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
240015001932	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
240015001933	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
240015001934	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
240015001935	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
240015001936	MutS domain I; Region: MutS_I; pfam01624
240015001937	MutS domain II; Region: MutS_II; pfam05188
240015001938	MutS domain III; Region: MutS_III; pfam05192
240015001939	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
240015001940	Walker A/P-loop; other site
240015001941	ATP binding site [chemical binding]; other site
240015001942	Q-loop/lid; other site
240015001943	ABC transporter signature motif; other site
240015001944	Walker B; other site
240015001945	D-loop; other site
240015001946	H-loop/switch region; other site
240015001947	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
240015001948	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
240015001949	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
240015001950	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
240015001951	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
240015001952	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
240015001953	oligomerisation interface [polypeptide binding]; other site
240015001954	mobile loop; other site
240015001955	roof hairpin; other site
240015001956	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
240015001957	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
240015001958	ring oligomerisation interface [polypeptide binding]; other site
240015001959	ATP/Mg binding site [chemical binding]; other site
240015001960	stacking interactions; other site
240015001961	hinge regions; other site
240015001962	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
240015001963	iron-sulfur cluster [ion binding]; other site
240015001964	[2Fe-2S] cluster binding site [ion binding]; other site
240015001965	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
240015001966	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
240015001967	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
240015001968	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
240015001969	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
240015001970	putative active site [active]
240015001971	catalytic triad [active]
240015001972	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
240015001973	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
240015001974	active site
240015001975	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
240015001976	classical (c) SDRs; Region: SDR_c; cd05233
240015001977	NAD(P) binding site [chemical binding]; other site
240015001978	active site
240015001979	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015001980	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
240015001981	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015001982	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
240015001983	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
240015001984	active site
240015001985	PHP-associated; Region: PHP_C; pfam13263
240015001986	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
240015001987	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
240015001988	Potassium binding sites [ion binding]; other site
240015001989	Cesium cation binding sites [ion binding]; other site
240015001990	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
240015001991	Protein export membrane protein; Region: SecD_SecF; cl14618
240015001992	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015001993	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015001994	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015001995	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
240015001996	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
240015001997	PAS domain; Region: PAS_9; pfam13426
240015001998	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
240015001999	putative active site [active]
240015002000	heme pocket [chemical binding]; other site
240015002001	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015002002	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015002003	metal binding site [ion binding]; metal-binding site
240015002004	active site
240015002005	I-site; other site
240015002006	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
240015002007	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
240015002008	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
240015002009	Bacterial sugar transferase; Region: Bac_transf; pfam02397
240015002010	aminotransferase; Validated; Region: PRK08175
240015002011	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240015002012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015002013	homodimer interface [polypeptide binding]; other site
240015002014	catalytic residue [active]
240015002015	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
240015002016	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
240015002017	putative ribose interaction site [chemical binding]; other site
240015002018	putative ADP binding site [chemical binding]; other site
240015002019	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
240015002020	active site
240015002021	nucleotide binding site [chemical binding]; other site
240015002022	HIGH motif; other site
240015002023	KMSKS motif; other site
240015002024	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
240015002025	dimer interface [polypeptide binding]; other site
240015002026	active site
240015002027	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
240015002028	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015002029	active site
240015002030	motif I; other site
240015002031	motif II; other site
240015002032	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
240015002033	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
240015002034	NADP binding site [chemical binding]; other site
240015002035	homopentamer interface [polypeptide binding]; other site
240015002036	substrate binding site [chemical binding]; other site
240015002037	active site
240015002038	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
240015002039	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
240015002040	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
240015002041	putative active site [active]
240015002042	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015002043	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240015002044	NAD(P) binding site [chemical binding]; other site
240015002045	active site
240015002046	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
240015002047	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
240015002048	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
240015002049	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
240015002050	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240015002051	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240015002052	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
240015002053	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
240015002054	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
240015002055	Chain length determinant protein; Region: Wzz; cl15801
240015002056	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
240015002057	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240015002058	PAS domain S-box; Region: sensory_box; TIGR00229
240015002059	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015002060	putative active site [active]
240015002061	heme pocket [chemical binding]; other site
240015002062	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015002063	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015002064	metal binding site [ion binding]; metal-binding site
240015002065	active site
240015002066	I-site; other site
240015002067	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240015002068	Escherichia coli YdjC-like family of  proteins; Region: YdjC; cd10808
240015002069	putative active site [active]
240015002070	YdjC motif; other site
240015002071	Mg binding site [ion binding]; other site
240015002072	putative homodimer interface [polypeptide binding]; other site
240015002073	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
240015002074	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
240015002075	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
240015002076	Histidine kinase; Region: His_kinase; pfam06580
240015002077	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015002078	ATP binding site [chemical binding]; other site
240015002079	Mg2+ binding site [ion binding]; other site
240015002080	G-X-G motif; other site
240015002081	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
240015002082	dimerization interface [polypeptide binding]; other site
240015002083	active site
240015002084	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
240015002085	Cysteine-rich domain; Region: CCG; pfam02754
240015002086	Cysteine-rich domain; Region: CCG; pfam02754
240015002087	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
240015002088	Ligand binding site [chemical binding]; other site
240015002089	Electron transfer flavoprotein domain; Region: ETF; pfam01012
240015002090	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
240015002091	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
240015002092	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
240015002093	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
240015002094	intersubunit interface [polypeptide binding]; other site
240015002095	active site
240015002096	Zn2+ binding site [ion binding]; other site
240015002097	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240015002098	Ligand Binding Site [chemical binding]; other site
240015002099	Predicted membrane protein [Function unknown]; Region: COG3918
240015002100	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240015002101	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015002102	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240015002103	DNA binding site [nucleotide binding]
240015002104	active site
240015002105	Int/Topo IB signature motif; other site
240015002106	catalytic residues [active]
240015002107	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
240015002108	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
240015002109	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015002110	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
240015002111	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
240015002112	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
240015002113	CRISPR repeat region, Dvulg subtype
240015002114	CRISPR spacer
240015002115	CRISPR spacer
240015002116	CRISPR spacer
240015002117	CRISPR spacer
240015002118	CRISPR spacer
240015002119	CRISPR spacer
240015002120	CRISPR spacer
240015002121	CRISPR spacer
240015002122	CRISPR spacer
240015002123	CRISPR spacer
240015002124	CRISPR spacer
240015002125	CRISPR spacer
240015002126	CRISPR spacer
240015002127	CRISPR spacer
240015002128	CRISPR spacer
240015002129	CRISPR spacer
240015002130	CRISPR spacer
240015002131	CRISPR spacer
240015002132	CRISPR spacer
240015002133	CRISPR spacer
240015002134	CRISPR spacer
240015002135	CRISPR spacer
240015002136	CRISPR spacer
240015002137	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
240015002138	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
240015002139	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
240015002140	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
240015002141	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09642
240015002142	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
240015002143	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
240015002144	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
240015002145	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
240015002146	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
240015002147	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
240015002148	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
240015002149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015002150	putative substrate translocation pore; other site
240015002151	Transcriptional regulators [Transcription]; Region: PurR; COG1609
240015002152	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
240015002153	DNA binding site [nucleotide binding]
240015002154	domain linker motif; other site
240015002155	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
240015002156	dimerization interface [polypeptide binding]; other site
240015002157	ligand binding site [chemical binding]; other site
240015002158	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
240015002159	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
240015002160	nucleotide binding site [chemical binding]; other site
240015002161	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
240015002162	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
240015002163	Protein of unknown function (DUF3309); Region: DUF3309; pfam11752
240015002164	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
240015002165	Fe-S cluster binding site [ion binding]; other site
240015002166	DNA binding site [nucleotide binding]
240015002167	active site
240015002168	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
240015002169	active site
240015002170	catalytic residues [active]
240015002171	NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712
240015002172	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
240015002173	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
240015002174	nucleotide binding site [chemical binding]; other site
240015002175	NEF interaction site [polypeptide binding]; other site
240015002176	SBD interface [polypeptide binding]; other site
240015002177	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
240015002178	GIY-YIG motif/motif A; other site
240015002179	putative active site [active]
240015002180	putative metal binding site [ion binding]; other site
240015002181	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
240015002182	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
240015002183	putative DNA binding site [nucleotide binding]; other site
240015002184	catalytic residue [active]
240015002185	putative H2TH interface [polypeptide binding]; other site
240015002186	putative catalytic residues [active]
240015002187	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
240015002188	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
240015002189	chaperone protein DnaJ; Provisional; Region: PRK10767
240015002190	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240015002191	HSP70 interaction site [polypeptide binding]; other site
240015002192	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
240015002193	Zn binding sites [ion binding]; other site
240015002194	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
240015002195	dimer interface [polypeptide binding]; other site
240015002196	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
240015002197	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
240015002198	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
240015002199	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
240015002200	DNA binding residues [nucleotide binding]
240015002201	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
240015002202	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
240015002203	ligand binding site; other site
240015002204	hypothetical protein; Provisional; Region: PRK07208
240015002205	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240015002206	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
240015002207	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
240015002208	active site
240015002209	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
240015002210	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240015002211	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
240015002212	active site lid residues [active]
240015002213	substrate binding pocket [chemical binding]; other site
240015002214	catalytic residues [active]
240015002215	substrate-Mg2+ binding site; other site
240015002216	aspartate-rich region 1; other site
240015002217	aspartate-rich region 2; other site
240015002218	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
240015002219	active site lid residues [active]
240015002220	substrate binding pocket [chemical binding]; other site
240015002221	catalytic residues [active]
240015002222	substrate-Mg2+ binding site; other site
240015002223	aspartate-rich region 1; other site
240015002224	aspartate-rich region 2; other site
240015002225	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240015002226	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
240015002227	NAD(P) binding site [chemical binding]; other site
240015002228	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240015002229	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
240015002230	putative NAD(P) binding site [chemical binding]; other site
240015002231	catalytic Zn binding site [ion binding]; other site
240015002232	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
240015002233	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
240015002234	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
240015002235	putative NADP binding site [chemical binding]; other site
240015002236	putative substrate binding site [chemical binding]; other site
240015002237	active site
240015002238	putative heme peroxidase; Provisional; Region: PRK12276
240015002239	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
240015002240	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
240015002241	acyl-activating enzyme (AAE) consensus motif; other site
240015002242	putative AMP binding site [chemical binding]; other site
240015002243	putative active site [active]
240015002244	putative CoA binding site [chemical binding]; other site
240015002245	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
240015002246	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
240015002247	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240015002248	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
240015002249	O-Antigen ligase; Region: Wzy_C; pfam04932
240015002250	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
240015002251	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
240015002252	SLBB domain; Region: SLBB; pfam10531
240015002253	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
240015002254	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
240015002255	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240015002256	P-loop; other site
240015002257	Magnesium ion binding site [ion binding]; other site
240015002258	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
240015002259	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
240015002260	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
240015002261	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
240015002262	Substrate binding site; other site
240015002263	Mg++ binding site; other site
240015002264	metal-binding site
240015002265	Mg++ binding site; other site
240015002266	metal-binding site
240015002267	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240015002268	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015002269	NAD(P) binding site [chemical binding]; other site
240015002270	active site
240015002271	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240015002272	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240015002273	active site
240015002274	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
240015002275	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
240015002276	putative translaldolase; Provisional; Region: PRK12376
240015002277	catalytic residue [active]
240015002278	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
240015002279	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015002280	active site
240015002281	motif I; other site
240015002282	motif II; other site
240015002283	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
240015002284	dimer interface [polypeptide binding]; other site
240015002285	active site
240015002286	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240015002287	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240015002288	active site
240015002289	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
240015002290	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240015002291	glycerol kinase; Provisional; Region: glpK; PRK00047
240015002292	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
240015002293	N- and C-terminal domain interface [polypeptide binding]; other site
240015002294	active site
240015002295	MgATP binding site [chemical binding]; other site
240015002296	catalytic site [active]
240015002297	metal binding site [ion binding]; metal-binding site
240015002298	glycerol binding site [chemical binding]; other site
240015002299	homotetramer interface [polypeptide binding]; other site
240015002300	homodimer interface [polypeptide binding]; other site
240015002301	FBP binding site [chemical binding]; other site
240015002302	protein IIAGlc interface [polypeptide binding]; other site
240015002303	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
240015002304	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
240015002305	amphipathic channel; other site
240015002306	Asn-Pro-Ala signature motifs; other site
240015002307	Conserved TM helix; Region: TM_helix; pfam05552
240015002308	trehalose synthase; Region: treS_nterm; TIGR02456
240015002309	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
240015002310	active site
240015002311	catalytic site [active]
240015002312	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
240015002313	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
240015002314	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
240015002315	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
240015002316	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
240015002317	active site
240015002318	homodimer interface [polypeptide binding]; other site
240015002319	catalytic site [active]
240015002320	acceptor binding site [chemical binding]; other site
240015002321	Predicted membrane protein [Function unknown]; Region: COG3918
240015002322	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
240015002323	Ligand binding site; other site
240015002324	Putative Catalytic site; other site
240015002325	DXD motif; other site
240015002326	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
240015002327	heme-binding site [chemical binding]; other site
240015002328	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
240015002329	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
240015002330	tetramer interface [polypeptide binding]; other site
240015002331	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015002332	catalytic residue [active]
240015002333	Cupin domain; Region: Cupin_2; pfam07883
240015002334	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015002335	NmrA-like family; Region: NmrA; pfam05368
240015002336	NAD(P) binding site [chemical binding]; other site
240015002337	active site
240015002338	Right handed beta helix region; Region: Beta_helix; pfam13229
240015002339	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015002340	amino acid transporter; Region: 2A0306; TIGR00909
240015002341	Melibiase; Region: Melibiase; pfam02065
240015002342	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
240015002343	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
240015002344	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
240015002345	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
240015002346	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
240015002347	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
240015002348	substrate binding site [chemical binding]; other site
240015002349	ATP binding site [chemical binding]; other site
240015002350	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
240015002351	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
240015002352	dimer interface [polypeptide binding]; other site
240015002353	active site
240015002354	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
240015002355	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013
240015002356	acetylornithine deacetylase; Validated; Region: PRK06915
240015002357	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
240015002358	metal binding site [ion binding]; metal-binding site
240015002359	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
240015002360	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
240015002361	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
240015002362	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
240015002363	RNA binding site [nucleotide binding]; other site
240015002364	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
240015002365	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
240015002366	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
240015002367	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
240015002368	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
240015002369	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015002370	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015002371	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
240015002372	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
240015002373	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015002374	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
240015002375	putative sugar binding sites [chemical binding]; other site
240015002376	Q-X-W motif; other site
240015002377	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015002378	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015002379	FtsX-like permease family; Region: FtsX; pfam02687
240015002380	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015002381	FtsX-like permease family; Region: FtsX; pfam02687
240015002382	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015002383	transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433
240015002384	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
240015002385	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
240015002386	active site
240015002387	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
240015002388	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
240015002389	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
240015002390	active site
240015002391	catalytic site [active]
240015002392	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015002393	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015002394	Tetratricopeptide repeat; Region: TPR_9; pfam13371
240015002395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015002396	binding surface
240015002397	TPR motif; other site
240015002398	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
240015002399	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015002400	TPR motif; other site
240015002401	binding surface
240015002402	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015002403	binding surface
240015002404	TPR motif; other site
240015002405	YceI-like domain; Region: YceI; pfam04264
240015002406	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
240015002407	substrate binding pocket [chemical binding]; other site
240015002408	substrate-Mg2+ binding site; other site
240015002409	aspartate-rich region 1; other site
240015002410	aspartate-rich region 2; other site
240015002411	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
240015002412	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015002413	FtsX-like permease family; Region: FtsX; pfam02687
240015002414	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240015002415	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240015002416	Walker A/P-loop; other site
240015002417	ATP binding site [chemical binding]; other site
240015002418	Q-loop/lid; other site
240015002419	ABC transporter signature motif; other site
240015002420	Walker B; other site
240015002421	D-loop; other site
240015002422	H-loop/switch region; other site
240015002423	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
240015002424	D-pathway; other site
240015002425	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
240015002426	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
240015002427	Cytochrome c; Region: Cytochrom_C; pfam00034
240015002428	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
240015002429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015002430	active site
240015002431	phosphorylation site [posttranslational modification]
240015002432	intermolecular recognition site; other site
240015002433	dimerization interface [polypeptide binding]; other site
240015002434	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015002435	PAS domain; Region: PAS_9; pfam13426
240015002436	putative active site [active]
240015002437	heme pocket [chemical binding]; other site
240015002438	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015002439	dimer interface [polypeptide binding]; other site
240015002440	phosphorylation site [posttranslational modification]
240015002441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015002442	ATP binding site [chemical binding]; other site
240015002443	Mg2+ binding site [ion binding]; other site
240015002444	G-X-G motif; other site
240015002445	Response regulator receiver domain; Region: Response_reg; pfam00072
240015002446	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015002447	active site
240015002448	phosphorylation site [posttranslational modification]
240015002449	intermolecular recognition site; other site
240015002450	dimerization interface [polypeptide binding]; other site
240015002451	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
240015002452	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240015002453	Phytochrome region; Region: PHY; pfam00360
240015002454	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015002455	dimer interface [polypeptide binding]; other site
240015002456	phosphorylation site [posttranslational modification]
240015002457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015002458	ATP binding site [chemical binding]; other site
240015002459	Mg2+ binding site [ion binding]; other site
240015002460	G-X-G motif; other site
240015002461	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
240015002462	heme binding pocket [chemical binding]; other site
240015002463	heme ligand [chemical binding]; other site
240015002464	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
240015002465	Two component regulator propeller; Region: Reg_prop; pfam07494
240015002466	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
240015002467	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015002468	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015002469	metal binding site [ion binding]; metal-binding site
240015002470	active site
240015002471	I-site; other site
240015002472	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
240015002473	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015002474	FtsX-like permease family; Region: FtsX; pfam02687
240015002475	FtsX-like permease family; Region: FtsX; pfam02687
240015002476	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240015002477	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240015002478	Walker A/P-loop; other site
240015002479	ATP binding site [chemical binding]; other site
240015002480	Q-loop/lid; other site
240015002481	ABC transporter signature motif; other site
240015002482	Walker B; other site
240015002483	D-loop; other site
240015002484	H-loop/switch region; other site
240015002485	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
240015002486	active site
240015002487	catalytic triad [active]
240015002488	oxyanion hole [active]
240015002489	switch loop; other site
240015002490	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
240015002491	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
240015002492	RNA binding site [nucleotide binding]; other site
240015002493	active site
240015002494	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
240015002495	GTP cyclohydrolase I; Provisional; Region: PLN03044
240015002496	homodecamer interface [polypeptide binding]; other site
240015002497	active site
240015002498	putative catalytic site residues [active]
240015002499	zinc binding site [ion binding]; other site
240015002500	GTP-CH-I/GFRP interaction surface; other site
240015002501	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240015002502	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
240015002503	active site
240015002504	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
240015002505	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240015002506	catalytic residues [active]
240015002507	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
240015002508	dimer interface [polypeptide binding]; other site
240015002509	substrate binding site [chemical binding]; other site
240015002510	ATP binding site [chemical binding]; other site
240015002511	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
240015002512	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
240015002513	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
240015002514	active site
240015002515	dimer interface [polypeptide binding]; other site
240015002516	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015002517	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
240015002518	FtsX-like permease family; Region: FtsX; pfam02687
240015002519	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015002520	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
240015002521	FtsX-like permease family; Region: FtsX; pfam02687
240015002522	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
240015002523	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
240015002524	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
240015002525	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
240015002526	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015002527	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
240015002528	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
240015002529	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
240015002530	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
240015002531	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
240015002532	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
240015002533	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240015002534	Coenzyme A binding pocket [chemical binding]; other site
240015002535	VPS10 domain; Region: VPS10; smart00602
240015002536	VPS10 domain; Region: VPS10; smart00602
240015002537	NADH dehydrogenase subunit B; Validated; Region: PRK06411
240015002538	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
240015002539	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
240015002540	Nitrogen regulatory protein P-II; Region: P-II; smart00938
240015002541	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
240015002542	[Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693
240015002543	metal binding triad; other site
240015002544	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
240015002545	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
240015002546	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
240015002547	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
240015002548	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
240015002549	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015002550	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015002551	metal binding site [ion binding]; metal-binding site
240015002552	active site
240015002553	I-site; other site
240015002554	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240015002555	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
240015002556	PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121
240015002557	apical/protease domain interface [polypeptide binding]; other site
240015002558	substrate binding [chemical binding]; other site
240015002559	dimer interface [polypeptide binding]; other site
240015002560	M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022
240015002561	dimer interface [polypeptide binding]; other site
240015002562	Peptidase family M28; Region: Peptidase_M28; pfam04389
240015002563	active site
240015002564	metal binding site [ion binding]; metal-binding site
240015002565	Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253
240015002566	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
240015002567	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
240015002568	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
240015002569	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
240015002570	probable DNA repair protein; Region: TIGR03623
240015002571	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
240015002572	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
240015002573	Part of AAA domain; Region: AAA_19; pfam13245
240015002574	Family description; Region: UvrD_C_2; pfam13538
240015002575	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
240015002576	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
240015002577	PhoU domain; Region: PhoU; pfam01895
240015002578	PhoU domain; Region: PhoU; pfam01895
240015002579	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
240015002580	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
240015002581	Walker A/P-loop; other site
240015002582	ATP binding site [chemical binding]; other site
240015002583	Q-loop/lid; other site
240015002584	ABC transporter signature motif; other site
240015002585	Walker B; other site
240015002586	D-loop; other site
240015002587	H-loop/switch region; other site
240015002588	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240015002589	dimerization interface [polypeptide binding]; other site
240015002590	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240015002591	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015002592	dimer interface [polypeptide binding]; other site
240015002593	phosphorylation site [posttranslational modification]
240015002594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015002595	ATP binding site [chemical binding]; other site
240015002596	Mg2+ binding site [ion binding]; other site
240015002597	G-X-G motif; other site
240015002598	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240015002599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015002600	active site
240015002601	phosphorylation site [posttranslational modification]
240015002602	intermolecular recognition site; other site
240015002603	dimerization interface [polypeptide binding]; other site
240015002604	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240015002605	DNA binding site [nucleotide binding]
240015002606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015002607	active site
240015002608	phosphorylation site [posttranslational modification]
240015002609	intermolecular recognition site; other site
240015002610	dimerization interface [polypeptide binding]; other site
240015002611	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
240015002612	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015002613	putative active site [active]
240015002614	heme pocket [chemical binding]; other site
240015002615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015002616	dimer interface [polypeptide binding]; other site
240015002617	phosphorylation site [posttranslational modification]
240015002618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015002619	ATP binding site [chemical binding]; other site
240015002620	Mg2+ binding site [ion binding]; other site
240015002621	G-X-G motif; other site
240015002622	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
240015002623	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
240015002624	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
240015002625	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
240015002626	short chain dehydrogenase; Provisional; Region: PRK07326
240015002627	classical (c) SDRs; Region: SDR_c; cd05233
240015002628	NAD(P) binding site [chemical binding]; other site
240015002629	active site
240015002630	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
240015002631	MoaE interaction surface [polypeptide binding]; other site
240015002632	thiocarboxylated glycine; other site
240015002633	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
240015002634	MoaE homodimer interface [polypeptide binding]; other site
240015002635	MoaD interaction [polypeptide binding]; other site
240015002636	active site residues [active]
240015002637	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240015002638	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240015002639	metal ion-dependent adhesion site (MIDAS); other site
240015002640	Sm and related proteins; Region: Sm_like; cl00259
240015002641	heptamer interface [polypeptide binding]; other site
240015002642	Sm1 motif; other site
240015002643	hexamer interface [polypeptide binding]; other site
240015002644	RNA binding site [nucleotide binding]; other site
240015002645	Sm2 motif; other site
240015002646	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
240015002647	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
240015002648	active site
240015002649	dimerization interface [polypeptide binding]; other site
240015002650	Ferredoxin [Energy production and conversion]; Region: COG1146
240015002651	4Fe-4S binding domain; Region: Fer4; cl02805
240015002652	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240015002653	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015002654	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015002655	DNA binding residues [nucleotide binding]
240015002656	shikimate kinase; Reviewed; Region: aroK; PRK00131
240015002657	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
240015002658	ADP binding site [chemical binding]; other site
240015002659	magnesium binding site [ion binding]; other site
240015002660	putative shikimate binding site; other site
240015002661	Domain of unknown function DUF20; Region: UPF0118; pfam01594
240015002662	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
240015002663	protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473
240015002664	UbiA prenyltransferase family; Region: UbiA; pfam01040
240015002665	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015002666	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
240015002667	Walker A/P-loop; other site
240015002668	ATP binding site [chemical binding]; other site
240015002669	Q-loop/lid; other site
240015002670	ABC transporter signature motif; other site
240015002671	Walker B; other site
240015002672	D-loop; other site
240015002673	H-loop/switch region; other site
240015002674	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
240015002675	ABC-2 type transporter; Region: ABC2_membrane; cl17235
240015002676	Protein of unknown function (DUF420); Region: DUF420; pfam04238
240015002677	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
240015002678	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
240015002679	dimer interface [polypeptide binding]; other site
240015002680	ssDNA binding site [nucleotide binding]; other site
240015002681	tetramer (dimer of dimers) interface [polypeptide binding]; other site
240015002682	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
240015002683	putative CheA interaction surface; other site
240015002684	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
240015002685	dimer interface [polypeptide binding]; other site
240015002686	putative CheW interface [polypeptide binding]; other site
240015002687	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
240015002688	putative binding surface; other site
240015002689	active site
240015002690	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
240015002691	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
240015002692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015002693	ATP binding site [chemical binding]; other site
240015002694	Mg2+ binding site [ion binding]; other site
240015002695	G-X-G motif; other site
240015002696	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
240015002697	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
240015002698	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
240015002699	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
240015002700	CheD chemotactic sensory transduction; Region: CheD; cl00810
240015002701	Response regulator receiver domain; Region: Response_reg; pfam00072
240015002702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015002703	active site
240015002704	phosphorylation site [posttranslational modification]
240015002705	intermolecular recognition site; other site
240015002706	dimerization interface [polypeptide binding]; other site
240015002707	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
240015002708	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
240015002709	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
240015002710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015002711	active site
240015002712	phosphorylation site [posttranslational modification]
240015002713	intermolecular recognition site; other site
240015002714	dimerization interface [polypeptide binding]; other site
240015002715	CheB methylesterase; Region: CheB_methylest; pfam01339
240015002716	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
240015002717	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
240015002718	Response regulator receiver domain; Region: Response_reg; pfam00072
240015002719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015002720	active site
240015002721	phosphorylation site [posttranslational modification]
240015002722	intermolecular recognition site; other site
240015002723	dimerization interface [polypeptide binding]; other site
240015002724	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
240015002725	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
240015002726	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240015002727	CoA binding domain; Region: CoA_binding; cl17356
240015002728	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
240015002729	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
240015002730	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240015002731	DsbD alpha interface [polypeptide binding]; other site
240015002732	catalytic residues [active]
240015002733	recombination factor protein RarA; Reviewed; Region: PRK13342
240015002734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015002735	Walker A motif; other site
240015002736	ATP binding site [chemical binding]; other site
240015002737	Walker B motif; other site
240015002738	arginine finger; other site
240015002739	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
240015002740	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
240015002741	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
240015002742	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
240015002743	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
240015002744	putative active site [active]
240015002745	Integral membrane protein DUF92; Region: DUF92; pfam01940
240015002746	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
240015002747	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
240015002748	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
240015002749	active site
240015002750	catalytic site [active]
240015002751	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
240015002752	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
240015002753	active site
240015002754	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
240015002755	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
240015002756	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
240015002757	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
240015002758	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
240015002759	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
240015002760	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
240015002761	protein binding site [polypeptide binding]; other site
240015002762	isocitrate dehydrogenase; Validated; Region: PRK09222
240015002763	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
240015002764	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
240015002765	putative active site [active]
240015002766	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240015002767	TPR repeat; Region: TPR_11; pfam13414
240015002768	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015002769	binding surface
240015002770	TPR motif; other site
240015002771	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240015002772	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240015002773	ligand binding site [chemical binding]; other site
240015002774	flexible hinge region; other site
240015002775	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
240015002776	putative switch regulator; other site
240015002777	non-specific DNA interactions [nucleotide binding]; other site
240015002778	DNA binding site [nucleotide binding]
240015002779	sequence specific DNA binding site [nucleotide binding]; other site
240015002780	putative cAMP binding site [chemical binding]; other site
240015002781	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
240015002782	dimerization interface [polypeptide binding]; other site
240015002783	metal binding site [ion binding]; metal-binding site
240015002784	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
240015002785	dimanganese center [ion binding]; other site
240015002786	Protein of unknown function (DUF507); Region: DUF507; cl01112
240015002787	Protein of unknown function (DUF507); Region: DUF507; cl01112
240015002788	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
240015002789	DHH family; Region: DHH; pfam01368
240015002790	DHHA1 domain; Region: DHHA1; pfam02272
240015002791	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
240015002792	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
240015002793	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
240015002794	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
240015002795	FAD binding site [chemical binding]; other site
240015002796	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
240015002797	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
240015002798	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
240015002799	homodimer interface [polypeptide binding]; other site
240015002800	substrate-cofactor binding pocket; other site
240015002801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015002802	catalytic residue [active]
240015002803	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
240015002804	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
240015002805	dimer interface [polypeptide binding]; other site
240015002806	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015002807	catalytic residue [active]
240015002808	Pleckstrin homology-like domain; Region: PH-like; cl17171
240015002809	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240015002810	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240015002811	metal ion-dependent adhesion site (MIDAS); other site
240015002812	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
240015002813	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
240015002814	active site
240015002815	metal binding site [ion binding]; metal-binding site
240015002816	Sporulation and spore germination; Region: Germane; pfam10646
240015002817	glutamate racemase; Provisional; Region: PRK00865
240015002818	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
240015002819	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
240015002820	NAD binding site [chemical binding]; other site
240015002821	homotetramer interface [polypeptide binding]; other site
240015002822	homodimer interface [polypeptide binding]; other site
240015002823	substrate binding site [chemical binding]; other site
240015002824	active site
240015002825	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
240015002826	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
240015002827	hypothetical protein; Provisional; Region: PRK02487
240015002828	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671
240015002829	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
240015002830	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
240015002831	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
240015002832	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
240015002833	Protein of unknown function (DUF465); Region: DUF465; cl01070
240015002834	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
240015002835	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240015002836	Coenzyme A binding pocket [chemical binding]; other site
240015002837	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
240015002838	Glycoprotease family; Region: Peptidase_M22; pfam00814
240015002839	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240015002840	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
240015002841	dimer interface [polypeptide binding]; other site
240015002842	substrate binding site [chemical binding]; other site
240015002843	metal binding site [ion binding]; metal-binding site
240015002844	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
240015002845	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
240015002846	Walker A; other site
240015002847	AIPR protein; Region: AIPR; pfam10592
240015002848	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
240015002849	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
240015002850	FAD binding site [chemical binding]; other site
240015002851	homotetramer interface [polypeptide binding]; other site
240015002852	substrate binding pocket [chemical binding]; other site
240015002853	catalytic base [active]
240015002854	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
240015002855	active site
240015002856	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
240015002857	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
240015002858	gamma subunit interface [polypeptide binding]; other site
240015002859	epsilon subunit interface [polypeptide binding]; other site
240015002860	LBP interface [polypeptide binding]; other site
240015002861	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
240015002862	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
240015002863	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
240015002864	alpha subunit interaction interface [polypeptide binding]; other site
240015002865	Walker A motif; other site
240015002866	ATP binding site [chemical binding]; other site
240015002867	Walker B motif; other site
240015002868	inhibitor binding site; inhibition site
240015002869	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
240015002870	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
240015002871	core domain interface [polypeptide binding]; other site
240015002872	delta subunit interface [polypeptide binding]; other site
240015002873	epsilon subunit interface [polypeptide binding]; other site
240015002874	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
240015002875	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
240015002876	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
240015002877	Walker A motif; other site
240015002878	ATP binding site [chemical binding]; other site
240015002879	Walker B motif; other site
240015002880	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
240015002881	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
240015002882	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
240015002883	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
240015002884	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
240015002885	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
240015002886	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
240015002887	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
240015002888	HflX GTPase family; Region: HflX; cd01878
240015002889	G1 box; other site
240015002890	GTP/Mg2+ binding site [chemical binding]; other site
240015002891	Switch I region; other site
240015002892	G2 box; other site
240015002893	G3 box; other site
240015002894	Switch II region; other site
240015002895	G4 box; other site
240015002896	G5 box; other site
240015002897	bacterial Hfq-like; Region: Hfq; cd01716
240015002898	hexamer interface [polypeptide binding]; other site
240015002899	Sm1 motif; other site
240015002900	RNA binding site [nucleotide binding]; other site
240015002901	Sm2 motif; other site
240015002902	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
240015002903	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
240015002904	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
240015002905	active site
240015002906	dimer interface [polypeptide binding]; other site
240015002907	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
240015002908	dimer interface [polypeptide binding]; other site
240015002909	active site
240015002910	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
240015002911	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
240015002912	active site
240015002913	substrate binding site [chemical binding]; other site
240015002914	metal binding site [ion binding]; metal-binding site
240015002915	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
240015002916	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
240015002917	Substrate binding site; other site
240015002918	Cupin domain; Region: Cupin_2; cl17218
240015002919	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
240015002920	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
240015002921	Uncharacterized conserved protein [Function unknown]; Region: COG3391
240015002922	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
240015002923	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
240015002924	ligand binding site; other site
240015002925	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
240015002926	Radical SAM superfamily; Region: Radical_SAM; pfam04055
240015002927	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015002928	FeS/SAM binding site; other site
240015002929	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
240015002930	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
240015002931	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
240015002932	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
240015002933	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
240015002934	active site
240015002935	dimer interface [polypeptide binding]; other site
240015002936	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
240015002937	Ligand Binding Site [chemical binding]; other site
240015002938	Molecular Tunnel; other site
240015002939	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
240015002940	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
240015002941	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
240015002942	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
240015002943	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
240015002944	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
240015002945	substrate binding site [chemical binding]; other site
240015002946	oxyanion hole (OAH) forming residues; other site
240015002947	trimer interface [polypeptide binding]; other site
240015002948	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
240015002949	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
240015002950	Substrate binding site; other site
240015002951	Mg++ binding site; other site
240015002952	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
240015002953	active site
240015002954	substrate binding site [chemical binding]; other site
240015002955	CoA binding site [chemical binding]; other site
240015002956	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240015002957	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015002958	DNA binding residues [nucleotide binding]
240015002959	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
240015002960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015002961	active site
240015002962	phosphorylation site [posttranslational modification]
240015002963	intermolecular recognition site; other site
240015002964	dimerization interface [polypeptide binding]; other site
240015002965	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
240015002966	Zn2+ binding site [ion binding]; other site
240015002967	Mg2+ binding site [ion binding]; other site
240015002968	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
240015002969	aromatic arch; other site
240015002970	DCoH dimer interaction site [polypeptide binding]; other site
240015002971	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
240015002972	DCoH tetramer interaction site [polypeptide binding]; other site
240015002973	substrate binding site [chemical binding]; other site
240015002974	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
240015002975	catalytic residues [active]
240015002976	peptide chain release factor 2; Validated; Region: prfB; PRK00578
240015002977	PCRF domain; Region: PCRF; pfam03462
240015002978	RF-1 domain; Region: RF-1; pfam00472
240015002979	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
240015002980	Integral membrane protein TerC family; Region: TerC; cl10468
240015002981	BON domain; Region: BON; pfam04972
240015002982	phosphodiesterase YaeI; Provisional; Region: PRK11340
240015002983	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
240015002984	putative active site [active]
240015002985	putative metal binding site [ion binding]; other site
240015002986	SurA N-terminal domain; Region: SurA_N_3; cl07813
240015002987	periplasmic folding chaperone; Provisional; Region: PRK10788
240015002988	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
240015002989	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
240015002990	4-alpha-glucanotransferase; Provisional; Region: PRK14508
240015002991	Protein of unknown function (DUF503); Region: DUF503; pfam04456
240015002992	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
240015002993	Leucine carboxyl methyltransferase; Region: LCM; cl01306
240015002994	Ribosome-binding factor A; Region: RBFA; pfam02033
240015002995	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
240015002996	DHH family; Region: DHH; pfam01368
240015002997	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
240015002998	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
240015002999	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
240015003000	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240015003001	Coenzyme A binding pocket [chemical binding]; other site
240015003002	YtxH-like protein; Region: YtxH; pfam12732
240015003003	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
240015003004	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
240015003005	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
240015003006	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015003007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015003008	active site
240015003009	phosphorylation site [posttranslational modification]
240015003010	intermolecular recognition site; other site
240015003011	dimerization interface [polypeptide binding]; other site
240015003012	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015003013	DNA binding residues [nucleotide binding]
240015003014	dimerization interface [polypeptide binding]; other site
240015003015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
240015003016	Histidine kinase; Region: HisKA_3; pfam07730
240015003017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015003018	ATP binding site [chemical binding]; other site
240015003019	Mg2+ binding site [ion binding]; other site
240015003020	G-X-G motif; other site
240015003021	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
240015003022	ABC-2 type transporter; Region: ABC2_membrane; cl17235
240015003023	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
240015003024	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
240015003025	Walker A/P-loop; other site
240015003026	ATP binding site [chemical binding]; other site
240015003027	Q-loop/lid; other site
240015003028	ABC transporter signature motif; other site
240015003029	Walker B; other site
240015003030	D-loop; other site
240015003031	H-loop/switch region; other site
240015003032	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015003033	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
240015003034	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
240015003035	cell division protein FtsZ; Validated; Region: PRK09330
240015003036	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
240015003037	nucleotide binding site [chemical binding]; other site
240015003038	SulA interaction site; other site
240015003039	cell division protein FtsA; Region: ftsA; TIGR01174
240015003040	Cell division protein FtsA; Region: FtsA; smart00842
240015003041	Cell division protein FtsA; Region: FtsA; pfam14450
240015003042	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
240015003043	Cell division protein FtsQ; Region: FtsQ; pfam03799
240015003044	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
240015003045	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
240015003046	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240015003047	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240015003048	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
240015003049	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
240015003050	active site
240015003051	homodimer interface [polypeptide binding]; other site
240015003052	cell division protein FtsW; Region: ftsW; TIGR02614
240015003053	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
240015003054	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240015003055	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240015003056	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
240015003057	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
240015003058	Mg++ binding site [ion binding]; other site
240015003059	putative catalytic motif [active]
240015003060	putative substrate binding site [chemical binding]; other site
240015003061	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
240015003062	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
240015003063	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240015003064	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
240015003065	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
240015003066	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240015003067	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240015003068	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
240015003069	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
240015003070	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
240015003071	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
240015003072	Cell division protein FtsL; Region: FtsL; cl11433
240015003073	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
240015003074	MraW methylase family; Region: Methyltransf_5; cl17771
240015003075	cell division protein MraZ; Reviewed; Region: PRK00326
240015003076	MraZ protein; Region: MraZ; pfam02381
240015003077	MraZ protein; Region: MraZ; pfam02381
240015003078	Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900
240015003079	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
240015003080	hydrophobic ligand binding site; other site
240015003081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003082	TPR motif; other site
240015003083	binding surface
240015003084	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003085	TPR motif; other site
240015003086	binding surface
240015003087	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
240015003088	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003089	binding surface
240015003090	TPR motif; other site
240015003091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240015003092	binding surface
240015003093	TPR motif; other site
240015003094	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240015003095	TPR motif; other site
240015003096	binding surface
240015003097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003098	binding surface
240015003099	TPR motif; other site
240015003100	TPR repeat; Region: TPR_11; pfam13414
240015003101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003102	binding surface
240015003103	TPR motif; other site
240015003104	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
240015003105	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
240015003106	Zn2+ binding site [ion binding]; other site
240015003107	Mg2+ binding site [ion binding]; other site
240015003108	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
240015003109	TadE-like protein; Region: TadE; pfam07811
240015003110	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
240015003111	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
240015003112	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
240015003113	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
240015003114	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
240015003115	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
240015003116	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
240015003117	active site
240015003118	dimerization interface [polypeptide binding]; other site
240015003119	AAA domain; Region: AAA_31; pfam13614
240015003120	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240015003121	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
240015003122	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
240015003123	ATP binding site [chemical binding]; other site
240015003124	Walker A motif; other site
240015003125	hexamer interface [polypeptide binding]; other site
240015003126	Walker B motif; other site
240015003127	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
240015003128	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
240015003129	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
240015003130	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
240015003131	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
240015003132	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
240015003133	active site
240015003134	Zn binding site [ion binding]; other site
240015003135	GMP synthase; Reviewed; Region: guaA; PRK00074
240015003136	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
240015003137	AMP/PPi binding site [chemical binding]; other site
240015003138	candidate oxyanion hole; other site
240015003139	catalytic triad [active]
240015003140	potential glutamine specificity residues [chemical binding]; other site
240015003141	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
240015003142	ATP Binding subdomain [chemical binding]; other site
240015003143	Ligand Binding sites [chemical binding]; other site
240015003144	Dimerization subdomain; other site
240015003145	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
240015003146	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
240015003147	HIGH motif; other site
240015003148	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
240015003149	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
240015003150	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
240015003151	active site
240015003152	KMSKS motif; other site
240015003153	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
240015003154	tRNA binding surface [nucleotide binding]; other site
240015003155	endonuclease IV; Provisional; Region: PRK01060
240015003156	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
240015003157	AP (apurinic/apyrimidinic) site pocket; other site
240015003158	DNA interaction; other site
240015003159	Metal-binding active site; metal-binding site
240015003160	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
240015003161	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
240015003162	active site
240015003163	dimer interface [polypeptide binding]; other site
240015003164	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
240015003165	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
240015003166	active site
240015003167	phosphate binding residues; other site
240015003168	catalytic residues [active]
240015003169	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
240015003170	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
240015003171	substrate binding site [chemical binding]; other site
240015003172	ATP binding site [chemical binding]; other site
240015003173	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
240015003174	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
240015003175	active site
240015003176	intersubunit interface [polypeptide binding]; other site
240015003177	catalytic residue [active]
240015003178	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
240015003179	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
240015003180	metal binding site [ion binding]; metal-binding site
240015003181	substrate binding pocket [chemical binding]; other site
240015003182	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
240015003183	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
240015003184	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
240015003185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015003186	NAD(P) binding site [chemical binding]; other site
240015003187	active site
240015003188	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015003189	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015003190	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015003191	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
240015003192	Protein export membrane protein; Region: SecD_SecF; cl14618
240015003193	Outer membrane efflux protein; Region: OEP; pfam02321
240015003194	Outer membrane efflux protein; Region: OEP; pfam02321
240015003195	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015003196	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015003197	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
240015003198	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240015003199	P-loop; other site
240015003200	Magnesium ion binding site [ion binding]; other site
240015003201	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
240015003202	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
240015003203	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
240015003204	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
240015003205	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240015003206	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
240015003207	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
240015003208	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
240015003209	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
240015003210	dimer interface [polypeptide binding]; other site
240015003211	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015003212	catalytic residue [active]
240015003213	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
240015003214	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
240015003215	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
240015003216	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
240015003217	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
240015003218	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
240015003219	KR domain; Region: KR; pfam08659
240015003220	putative NADP binding site [chemical binding]; other site
240015003221	active site
240015003222	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
240015003223	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
240015003224	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
240015003225	active site
240015003226	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240015003227	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
240015003228	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240015003229	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
240015003230	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240015003231	inhibitor-cofactor binding pocket; inhibition site
240015003232	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015003233	catalytic residue [active]
240015003234	Condensation domain; Region: Condensation; pfam00668
240015003235	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240015003236	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240015003237	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
240015003238	acyl-activating enzyme (AAE) consensus motif; other site
240015003239	AMP binding site [chemical binding]; other site
240015003240	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240015003241	Condensation domain; Region: Condensation; pfam00668
240015003242	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240015003243	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240015003244	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
240015003245	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
240015003246	Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843
240015003247	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
240015003248	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
240015003249	Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843
240015003250	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240015003251	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
240015003252	acyl-activating enzyme (AAE) consensus motif; other site
240015003253	AMP binding site [chemical binding]; other site
240015003254	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240015003255	Condensation domain; Region: Condensation; pfam00668
240015003256	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240015003257	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
240015003258	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
240015003259	acyl-activating enzyme (AAE) consensus motif; other site
240015003260	AMP binding site [chemical binding]; other site
240015003261	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240015003262	Condensation domain; Region: Condensation; pfam00668
240015003263	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240015003264	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
240015003265	Condensation domain; Region: Condensation; pfam00668
240015003266	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
240015003267	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
240015003268	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
240015003269	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
240015003270	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
240015003271	FAD binding domain; Region: FAD_binding_4; pfam01565
240015003272	Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129
240015003273	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
240015003274	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
240015003275	ligand-binding site [chemical binding]; other site
240015003276	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015003277	active site
240015003278	motif I; other site
240015003279	motif II; other site
240015003280	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240015003281	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240015003282	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015003283	Walker A/P-loop; other site
240015003284	ATP binding site [chemical binding]; other site
240015003285	Q-loop/lid; other site
240015003286	ABC transporter signature motif; other site
240015003287	Walker B; other site
240015003288	D-loop; other site
240015003289	H-loop/switch region; other site
240015003290	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
240015003291	Ligand binding site; other site
240015003292	Putative Catalytic site; other site
240015003293	DXD motif; other site
240015003294	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003295	TPR repeat; Region: TPR_11; pfam13414
240015003296	binding surface
240015003297	TPR motif; other site
240015003298	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240015003299	binding surface
240015003300	TPR motif; other site
240015003301	TPR repeat; Region: TPR_11; pfam13414
240015003302	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
240015003303	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
240015003304	Phage Tail Collar Domain; Region: Collar; pfam07484
240015003305	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240015003306	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
240015003307	Coenzyme A binding pocket [chemical binding]; other site
240015003308	NHL repeat; Region: NHL; pfam01436
240015003309	NHL repeat; Region: NHL; pfam01436
240015003310	NHL repeat; Region: NHL; pfam01436
240015003311	NHL repeat; Region: NHL; pfam01436
240015003312	TrbC/VIRB2 family; Region: TrbC; pfam04956
240015003313	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
240015003314	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
240015003315	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
240015003316	Domain of unknown function DUF87; Region: DUF87; pfam01935
240015003317	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
240015003318	VirB7 interaction site; other site
240015003319	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
240015003320	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
240015003321	VirB8 protein; Region: VirB8; pfam04335
240015003322	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
240015003323	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
240015003324	dimer interface [polypeptide binding]; other site
240015003325	ssDNA binding site [nucleotide binding]; other site
240015003326	tetramer (dimer of dimers) interface [polypeptide binding]; other site
240015003327	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
240015003328	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
240015003329	ATP binding site [chemical binding]; other site
240015003330	Walker A motif; other site
240015003331	hexamer interface [polypeptide binding]; other site
240015003332	Walker B motif; other site
240015003333	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
240015003334	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
240015003335	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
240015003336	Walker A motif; other site
240015003337	ATP binding site [chemical binding]; other site
240015003338	Walker B motif; other site
240015003339	TrwC relaxase; Region: TrwC; pfam08751
240015003340	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
240015003341	AAA domain; Region: AAA_30; pfam13604
240015003342	Family description; Region: UvrD_C_2; pfam13538
240015003343	Transposase domain (DUF772); Region: DUF772; pfam05598
240015003344	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
240015003345	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240015003346	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015003347	S-adenosylmethionine binding site [chemical binding]; other site
240015003348	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
240015003349	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
240015003350	metal-binding site [ion binding]
240015003351	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240015003352	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015003353	motif II; other site
240015003354	Predicted permease; Region: DUF318; cl17795
240015003355	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
240015003356	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
240015003357	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
240015003358	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
240015003359	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
240015003360	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015003361	YtkA-like; Region: YtkA; pfam13115
240015003362	Outer membrane efflux protein; Region: OEP; pfam02321
240015003363	Outer membrane efflux protein; Region: OEP; pfam02321
240015003364	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240015003365	dimerization interface [polypeptide binding]; other site
240015003366	putative DNA binding site [nucleotide binding]; other site
240015003367	putative Zn2+ binding site [ion binding]; other site
240015003368	tetrahydromethanopterin S-methyltransferase subunit A; Provisional; Region: PRK00964
240015003369	Tetrahydromethanopterin S-methyltransferase, subunit A; Region: MtrA; cl04449
240015003370	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
240015003371	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
240015003372	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
240015003373	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
240015003374	Iron permease FTR1 family; Region: FTR1; cl00475
240015003375	YHS domain; Region: YHS; pfam04945
240015003376	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
240015003377	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240015003378	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015003379	motif II; other site
240015003380	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240015003381	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015003382	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
240015003383	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
240015003384	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
240015003385	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
240015003386	Multicopper oxidase; Region: Cu-oxidase; pfam00394
240015003387	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
240015003388	Domain of unknown function DUF302; Region: DUF302; cl01364
240015003389	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015003390	RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1
240015003391	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015003392	DNA binding residues [nucleotide binding]
240015003393	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
240015003394	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
240015003395	ParB-like nuclease domain; Region: ParBc; pfam02195
240015003396	KorB domain; Region: KorB; pfam08535
240015003397	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
240015003398	DNA binding residues [nucleotide binding]
240015003399	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
240015003400	dimer interface [polypeptide binding]; other site
240015003401	mercury binding site [ion binding]; other site
240015003402	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
240015003403	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240015003404	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
240015003405	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
240015003406	metal-binding site [ion binding]
240015003407	Transcriptional regulator [Transcription]; Region: LysR; COG0583
240015003408	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240015003409	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
240015003410	dimerization interface [polypeptide binding]; other site
240015003411	substrate binding pocket [chemical binding]; other site
240015003412	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
240015003413	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
240015003414	active site
240015003415	catalytic residues [active]
240015003416	DNA binding site [nucleotide binding]
240015003417	Int/Topo IB signature motif; other site
240015003418	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
240015003419	pyrroline-5-carboxylate reductase; Region: PLN02688
240015003420	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
240015003421	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
240015003422	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
240015003423	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
240015003424	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
240015003425	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
240015003426	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
240015003427	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
240015003428	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
240015003429	ligand binding site [chemical binding]; other site
240015003430	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14669
240015003431	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
240015003432	GIY-YIG motif/motif A; other site
240015003433	active site
240015003434	catalytic site [active]
240015003435	putative DNA binding site [nucleotide binding]; other site
240015003436	metal binding site [ion binding]; metal-binding site
240015003437	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
240015003438	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
240015003439	active site
240015003440	Protein phosphatase 2C; Region: PP2C; pfam00481
240015003441	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240015003442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015003443	active site
240015003444	phosphorylation site [posttranslational modification]
240015003445	intermolecular recognition site; other site
240015003446	dimerization interface [polypeptide binding]; other site
240015003447	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240015003448	DNA binding site [nucleotide binding]
240015003449	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
240015003450	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
240015003451	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
240015003452	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
240015003453	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
240015003454	active site
240015003455	ATP binding site [chemical binding]; other site
240015003456	substrate binding site [chemical binding]; other site
240015003457	activation loop (A-loop); other site
240015003458	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
240015003459	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
240015003460	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
240015003461	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003462	TPR motif; other site
240015003463	binding surface
240015003464	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
240015003465	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
240015003466	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015003467	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
240015003468	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240015003469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015003470	active site
240015003471	phosphorylation site [posttranslational modification]
240015003472	intermolecular recognition site; other site
240015003473	dimerization interface [polypeptide binding]; other site
240015003474	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240015003475	DNA binding site [nucleotide binding]
240015003476	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
240015003477	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240015003478	dimerization interface [polypeptide binding]; other site
240015003479	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015003480	dimer interface [polypeptide binding]; other site
240015003481	phosphorylation site [posttranslational modification]
240015003482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015003483	ATP binding site [chemical binding]; other site
240015003484	Mg2+ binding site [ion binding]; other site
240015003485	G-X-G motif; other site
240015003486	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015003487	Transcriptional regulators [Transcription]; Region: PurR; COG1609
240015003488	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
240015003489	DNA binding site [nucleotide binding]
240015003490	domain linker motif; other site
240015003491	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
240015003492	dimerization interface [polypeptide binding]; other site
240015003493	ligand binding site [chemical binding]; other site
240015003494	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
240015003495	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
240015003496	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
240015003497	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
240015003498	Carboxylesterase family; Region: COesterase; pfam00135
240015003499	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
240015003500	substrate binding pocket [chemical binding]; other site
240015003501	catalytic triad [active]
240015003502	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240015003503	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
240015003504	putative metal binding site; other site
240015003505	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015003506	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
240015003507	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
240015003508	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
240015003509	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
240015003510	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
240015003511	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
240015003512	ApbE family; Region: ApbE; pfam02424
240015003513	FMN-binding domain; Region: FMN_bind; pfam04205
240015003514	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
240015003515	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
240015003516	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240015003517	N-terminal plug; other site
240015003518	ligand-binding site [chemical binding]; other site
240015003519	Carboxylesterase family; Region: COesterase; pfam00135
240015003520	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
240015003521	substrate binding pocket [chemical binding]; other site
240015003522	catalytic triad [active]
240015003523	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
240015003524	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
240015003525	NADP binding site [chemical binding]; other site
240015003526	substrate binding site [chemical binding]; other site
240015003527	active site
240015003528	short chain dehydrogenase; Provisional; Region: PRK05854
240015003529	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
240015003530	putative catalytic residues [active]
240015003531	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
240015003532	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
240015003533	FMN binding site [chemical binding]; other site
240015003534	active site
240015003535	substrate binding site [chemical binding]; other site
240015003536	catalytic residue [active]
240015003537	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240015003538	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015003539	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015003540	Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589
240015003541	putative active site [active]
240015003542	catalytic site [active]
240015003543	putative metal binding site [ion binding]; other site
240015003544	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
240015003545	peptidase domain interface [polypeptide binding]; other site
240015003546	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
240015003547	active site
240015003548	catalytic triad [active]
240015003549	calcium binding site [ion binding]; other site
240015003550	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
240015003551	Two component regulator propeller; Region: Reg_prop; pfam07494
240015003552	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
240015003553	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
240015003554	Histidine kinase; Region: HisKA_3; pfam07730
240015003555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015003556	ATP binding site [chemical binding]; other site
240015003557	Mg2+ binding site [ion binding]; other site
240015003558	G-X-G motif; other site
240015003559	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015003560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015003561	active site
240015003562	phosphorylation site [posttranslational modification]
240015003563	intermolecular recognition site; other site
240015003564	dimerization interface [polypeptide binding]; other site
240015003565	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015003566	DNA binding residues [nucleotide binding]
240015003567	dimerization interface [polypeptide binding]; other site
240015003568	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
240015003569	DNA-binding site [nucleotide binding]; DNA binding site
240015003570	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
240015003571	PIN domain; Region: PIN_3; cl17397
240015003572	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
240015003573	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
240015003574	active site
240015003575	catalytic triad [active]
240015003576	calcium binding site [ion binding]; other site
240015003577	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
240015003578	Gloeo_Verruco repeat; Region: Gloeo_Verruco; TIGR03803
240015003579	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240015003580	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240015003581	DNA binding site [nucleotide binding]
240015003582	TPR repeat; Region: TPR_11; pfam13414
240015003583	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003584	TPR motif; other site
240015003585	binding surface
240015003586	Transposase; Region: DEDD_Tnp_IS110; pfam01548
240015003587	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
240015003588	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
240015003589	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
240015003590	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
240015003591	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015003592	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
240015003593	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015003594	Predicted integral membrane protein [Function unknown]; Region: COG5616
240015003595	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003596	TPR motif; other site
240015003597	binding surface
240015003598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
240015003599	active site
240015003600	dimerization interface [polypeptide binding]; other site
240015003601	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
240015003602	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015003603	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015003604	DNA binding residues [nucleotide binding]
240015003605	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
240015003606	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240015003607	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
240015003608	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
240015003609	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
240015003610	benzoylformate decarboxylase; Reviewed; Region: PRK07092
240015003611	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
240015003612	PYR/PP interface [polypeptide binding]; other site
240015003613	dimer interface [polypeptide binding]; other site
240015003614	TPP binding site [chemical binding]; other site
240015003615	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
240015003616	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
240015003617	TPP-binding site [chemical binding]; other site
240015003618	dimer interface [polypeptide binding]; other site
240015003619	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
240015003620	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
240015003621	NADP binding site [chemical binding]; other site
240015003622	dimer interface [polypeptide binding]; other site
240015003623	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
240015003624	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
240015003625	NAD(P) binding site [chemical binding]; other site
240015003626	catalytic residues [active]
240015003627	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
240015003628	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
240015003629	Histidine kinase; Region: HisKA_3; pfam07730
240015003630	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
240015003631	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015003632	ATP binding site [chemical binding]; other site
240015003633	Mg2+ binding site [ion binding]; other site
240015003634	G-X-G motif; other site
240015003635	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015003636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015003637	active site
240015003638	phosphorylation site [posttranslational modification]
240015003639	intermolecular recognition site; other site
240015003640	dimerization interface [polypeptide binding]; other site
240015003641	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015003642	DNA binding residues [nucleotide binding]
240015003643	dimerization interface [polypeptide binding]; other site
240015003644	invasion protein regulator; Provisional; Region: PRK12370
240015003645	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
240015003646	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
240015003647	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
240015003648	Histidine kinase; Region: HisKA_3; pfam07730
240015003649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015003650	ATP binding site [chemical binding]; other site
240015003651	Mg2+ binding site [ion binding]; other site
240015003652	G-X-G motif; other site
240015003653	putative transposase OrfB; Reviewed; Region: PHA02517
240015003654	HTH-like domain; Region: HTH_21; pfam13276
240015003655	Integrase core domain; Region: rve; pfam00665
240015003656	Integrase core domain; Region: rve_3; pfam13683
240015003657	Transposase; Region: HTH_Tnp_1; pfam01527
240015003658	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
240015003659	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015003660	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015003661	DNA binding residues [nucleotide binding]
240015003662	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
240015003663	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
240015003664	Proline dehydrogenase; Region: Pro_dh; cl03282
240015003665	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240015003666	GAF domain; Region: GAF; pfam01590
240015003667	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015003668	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015003669	metal binding site [ion binding]; metal-binding site
240015003670	active site
240015003671	I-site; other site
240015003672	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
240015003673	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
240015003674	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
240015003675	putative FMN binding site [chemical binding]; other site
240015003676	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015003677	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015003678	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015003679	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
240015003680	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
240015003681	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
240015003682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015003683	putative substrate translocation pore; other site
240015003684	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
240015003685	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
240015003686	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
240015003687	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
240015003688	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
240015003689	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
240015003690	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
240015003691	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
240015003692	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015003693	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015003694	Transcriptional regulator PadR-like family; Region: PadR; cl17335
240015003695	Family description; Region: VCBS; pfam13517
240015003696	Family description; Region: VCBS; pfam13517
240015003697	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
240015003698	Family description; Region: VCBS; pfam13517
240015003699	Family description; Region: VCBS; pfam13517
240015003700	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
240015003701	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
240015003702	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003703	TPR repeat; Region: TPR_11; pfam13414
240015003704	binding surface
240015003705	TPR motif; other site
240015003706	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015003707	binding surface
240015003708	TPR repeat; Region: TPR_11; pfam13414
240015003709	TPR motif; other site
240015003710	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240015003711	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240015003712	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
240015003713	Asp-box motif; other site
240015003714	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
240015003715	Asp-box motif; other site
240015003716	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
240015003717	Asp-box motif; other site
240015003718	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
240015003719	Asp-box motif; other site
240015003720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015003721	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
240015003722	FeS/SAM binding site; other site
240015003723	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
240015003724	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240015003725	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
240015003726	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240015003727	NAD binding site [chemical binding]; other site
240015003728	substrate binding site [chemical binding]; other site
240015003729	active site
240015003730	PIN domain; Region: PIN_3; pfam13470
240015003731	Helix-turn-helix domain; Region: HTH_17; cl17695
240015003732	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015003733	putative rSAM target protein, CGCGG family; Region: target_X_rSAM; TIGR03995
240015003734	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015003735	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015003736	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240015003737	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240015003738	Walker A/P-loop; other site
240015003739	ATP binding site [chemical binding]; other site
240015003740	Q-loop/lid; other site
240015003741	ABC transporter signature motif; other site
240015003742	Walker B; other site
240015003743	D-loop; other site
240015003744	H-loop/switch region; other site
240015003745	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
240015003746	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
240015003747	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
240015003748	dimerization interface [polypeptide binding]; other site
240015003749	putative ATP binding site [chemical binding]; other site
240015003750	Fic/DOC family; Region: Fic; pfam02661
240015003751	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
240015003752	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
240015003753	active site
240015003754	substrate binding site [chemical binding]; other site
240015003755	cosubstrate binding site; other site
240015003756	catalytic site [active]
240015003757	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240015003758	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240015003759	ligand binding site [chemical binding]; other site
240015003760	flexible hinge region; other site
240015003761	Protein of unknown function (DUF1003); Region: DUF1003; cl01831
240015003762	lipoyl synthase; Provisional; Region: PRK05481
240015003763	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015003764	FeS/SAM binding site; other site
240015003765	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
240015003766	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
240015003767	active site
240015003768	(T/H)XGH motif; other site
240015003769	Oligomerisation domain; Region: Oligomerisation; pfam02410
240015003770	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
240015003771	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
240015003772	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
240015003773	putative active site [active]
240015003774	putative glutamate synthase subunit beta; Provisional; Region: PRK12770
240015003775	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240015003776	Homeodomain-like domain; Region: HTH_23; cl17451
240015003777	Integrase core domain; Region: rve; pfam00665
240015003778	Integrase core domain; Region: rve_3; pfam13683
240015003779	replicative DNA helicase; Region: DnaB; TIGR00665
240015003780	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
240015003781	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
240015003782	Walker A motif; other site
240015003783	ATP binding site [chemical binding]; other site
240015003784	Walker B motif; other site
240015003785	DNA binding loops [nucleotide binding]
240015003786	amidophosphoribosyltransferase; Provisional; Region: PRK09123
240015003787	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
240015003788	active site
240015003789	tetramer interface [polypeptide binding]; other site
240015003790	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240015003791	active site
240015003792	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
240015003793	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
240015003794	dimerization interface [polypeptide binding]; other site
240015003795	ATP binding site [chemical binding]; other site
240015003796	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
240015003797	dimerization interface [polypeptide binding]; other site
240015003798	ATP binding site [chemical binding]; other site
240015003799	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
240015003800	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
240015003801	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
240015003802	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
240015003803	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
240015003804	ligand binding site [chemical binding]; other site
240015003805	polycystin cation channel protein; Region: PCC; TIGR00864
240015003806	transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433
240015003807	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015003808	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015003809	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015003810	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015003811	FtsX-like permease family; Region: FtsX; pfam02687
240015003812	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015003813	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
240015003814	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
240015003815	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
240015003816	Protein of unknown function (DUF1569); Region: DUF1569; pfam07606
240015003817	threonine dehydratase; Provisional; Region: PRK08198
240015003818	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
240015003819	tetramer interface [polypeptide binding]; other site
240015003820	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015003821	catalytic residue [active]
240015003822	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
240015003823	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240015003824	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015003825	Isochorismatase family; Region: Isochorismatase; pfam00857
240015003826	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
240015003827	catalytic triad [active]
240015003828	conserved cis-peptide bond; other site
240015003829	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015003830	Major Facilitator Superfamily; Region: MFS_1; pfam07690
240015003831	putative substrate translocation pore; other site
240015003832	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015003833	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
240015003834	EamA-like transporter family; Region: EamA; pfam00892
240015003835	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
240015003836	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
240015003837	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015003838	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
240015003839	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015003840	OsmC-like protein; Region: OsmC; pfam02566
240015003841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015003842	S-adenosylmethionine binding site [chemical binding]; other site
240015003843	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
240015003844	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
240015003845	Protein export membrane protein; Region: SecD_SecF; cl14618
240015003846	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015003847	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015003848	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015003849	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
240015003850	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240015003851	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015003852	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
240015003853	Putative zinc-finger; Region: zf-HC2; pfam13490
240015003854	Carboxylesterase family; Region: COesterase; pfam00135
240015003855	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
240015003856	substrate binding pocket [chemical binding]; other site
240015003857	catalytic triad [active]
240015003858	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
240015003859	Uncharacterized conserved protein [Function unknown]; Region: COG2128
240015003860	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240015003861	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015003862	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
240015003863	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
240015003864	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
240015003865	alphaNTD homodimer interface [polypeptide binding]; other site
240015003866	alphaNTD - beta interaction site [polypeptide binding]; other site
240015003867	alphaNTD - beta' interaction site [polypeptide binding]; other site
240015003868	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
240015003869	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
240015003870	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
240015003871	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240015003872	RNA binding surface [nucleotide binding]; other site
240015003873	30S ribosomal protein S11; Validated; Region: PRK05309
240015003874	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
240015003875	30S ribosomal protein S13; Region: bact_S13; TIGR03631
240015003876	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
240015003877	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
240015003878	rRNA binding site [nucleotide binding]; other site
240015003879	predicted 30S ribosome binding site; other site
240015003880	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
240015003881	active site
240015003882	adenylate kinase; Reviewed; Region: adk; PRK00279
240015003883	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
240015003884	AMP-binding site [chemical binding]; other site
240015003885	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
240015003886	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
240015003887	SecY translocase; Region: SecY; pfam00344
240015003888	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
240015003889	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
240015003890	23S rRNA binding site [nucleotide binding]; other site
240015003891	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
240015003892	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
240015003893	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
240015003894	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
240015003895	23S rRNA interface [nucleotide binding]; other site
240015003896	L21e interface [polypeptide binding]; other site
240015003897	5S rRNA interface [nucleotide binding]; other site
240015003898	L27 interface [polypeptide binding]; other site
240015003899	L5 interface [polypeptide binding]; other site
240015003900	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
240015003901	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
240015003902	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
240015003903	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
240015003904	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
240015003905	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
240015003906	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
240015003907	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
240015003908	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
240015003909	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
240015003910	RNA binding site [nucleotide binding]; other site
240015003911	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
240015003912	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
240015003913	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
240015003914	putative translocon interaction site; other site
240015003915	23S rRNA interface [nucleotide binding]; other site
240015003916	signal recognition particle (SRP54) interaction site; other site
240015003917	L23 interface [polypeptide binding]; other site
240015003918	trigger factor interaction site; other site
240015003919	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
240015003920	23S rRNA interface [nucleotide binding]; other site
240015003921	5S rRNA interface [nucleotide binding]; other site
240015003922	putative antibiotic binding site [chemical binding]; other site
240015003923	L25 interface [polypeptide binding]; other site
240015003924	L27 interface [polypeptide binding]; other site
240015003925	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
240015003926	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
240015003927	G-X-X-G motif; other site
240015003928	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
240015003929	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
240015003930	putative translocon binding site; other site
240015003931	protein-rRNA interface [nucleotide binding]; other site
240015003932	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
240015003933	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
240015003934	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
240015003935	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
240015003936	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
240015003937	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
240015003938	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
240015003939	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
240015003940	elongation factor Tu; Reviewed; Region: PRK00049
240015003941	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
240015003942	G1 box; other site
240015003943	GEF interaction site [polypeptide binding]; other site
240015003944	GTP/Mg2+ binding site [chemical binding]; other site
240015003945	Switch I region; other site
240015003946	G2 box; other site
240015003947	G3 box; other site
240015003948	Switch II region; other site
240015003949	G4 box; other site
240015003950	G5 box; other site
240015003951	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
240015003952	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
240015003953	Antibiotic Binding Site [chemical binding]; other site
240015003954	elongation factor G; Reviewed; Region: PRK00007
240015003955	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
240015003956	G1 box; other site
240015003957	putative GEF interaction site [polypeptide binding]; other site
240015003958	GTP/Mg2+ binding site [chemical binding]; other site
240015003959	Switch I region; other site
240015003960	G2 box; other site
240015003961	G3 box; other site
240015003962	Switch II region; other site
240015003963	G4 box; other site
240015003964	G5 box; other site
240015003965	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
240015003966	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
240015003967	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
240015003968	30S ribosomal protein S7; Validated; Region: PRK05302
240015003969	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
240015003970	S17 interaction site [polypeptide binding]; other site
240015003971	S8 interaction site; other site
240015003972	16S rRNA interaction site [nucleotide binding]; other site
240015003973	streptomycin interaction site [chemical binding]; other site
240015003974	23S rRNA interaction site [nucleotide binding]; other site
240015003975	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
240015003976	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240015003977	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
240015003978	Coenzyme A binding pocket [chemical binding]; other site
240015003979	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
240015003980	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015003981	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
240015003982	ATP cone domain; Region: ATP-cone; pfam03477
240015003983	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
240015003984	isocitrate dehydrogenase; Validated; Region: PRK06451
240015003985	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
240015003986	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
240015003987	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
240015003988	aspartate kinase III; Validated; Region: PRK09084
240015003989	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
240015003990	putative catalytic residues [active]
240015003991	nucleotide binding site [chemical binding]; other site
240015003992	aspartate binding site [chemical binding]; other site
240015003993	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
240015003994	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
240015003995	dihydrodipicolinate reductase; Provisional; Region: PRK00048
240015003996	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
240015003997	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
240015003998	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
240015003999	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
240015004000	putative metal binding site; other site
240015004001	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
240015004002	dihydrodipicolinate synthase; Region: dapA; TIGR00674
240015004003	dimer interface [polypeptide binding]; other site
240015004004	active site
240015004005	catalytic residue [active]
240015004006	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
240015004007	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
240015004008	active site
240015004009	substrate binding site [chemical binding]; other site
240015004010	trimer interface [polypeptide binding]; other site
240015004011	CoA binding site [chemical binding]; other site
240015004012	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
240015004013	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240015004014	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
240015004015	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
240015004016	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
240015004017	tetramer interface [polypeptide binding]; other site
240015004018	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015004019	catalytic residue [active]
240015004020	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
240015004021	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
240015004022	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
240015004023	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
240015004024	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
240015004025	Response regulator receiver domain; Region: Response_reg; pfam00072
240015004026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015004027	active site
240015004028	phosphorylation site [posttranslational modification]
240015004029	intermolecular recognition site; other site
240015004030	dimerization interface [polypeptide binding]; other site
240015004031	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015004032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015004033	active site
240015004034	phosphorylation site [posttranslational modification]
240015004035	intermolecular recognition site; other site
240015004036	dimerization interface [polypeptide binding]; other site
240015004037	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015004038	DNA binding residues [nucleotide binding]
240015004039	dimerization interface [polypeptide binding]; other site
240015004040	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
240015004041	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
240015004042	ligand binding site [chemical binding]; other site
240015004043	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
240015004044	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
240015004045	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
240015004046	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015004047	NAD(P) binding site [chemical binding]; other site
240015004048	active site
240015004049	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
240015004050	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
240015004051	putative NAD(P) binding site [chemical binding]; other site
240015004052	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015004053	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
240015004054	Walker A/P-loop; other site
240015004055	ATP binding site [chemical binding]; other site
240015004056	Q-loop/lid; other site
240015004057	ABC transporter signature motif; other site
240015004058	Walker B; other site
240015004059	D-loop; other site
240015004060	H-loop/switch region; other site
240015004061	ABC-2 type transporter; Region: ABC2_membrane; cl17235
240015004062	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
240015004063	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240015004064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015004065	ATP binding site [chemical binding]; other site
240015004066	Mg2+ binding site [ion binding]; other site
240015004067	G-X-G motif; other site
240015004068	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
240015004069	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
240015004070	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240015004071	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
240015004072	Aspartase; Region: Aspartase; cd01357
240015004073	active sites [active]
240015004074	tetramer interface [polypeptide binding]; other site
240015004075	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
240015004076	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015004077	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015004078	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
240015004079	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
240015004080	NAD binding site [chemical binding]; other site
240015004081	substrate binding site [chemical binding]; other site
240015004082	homodimer interface [polypeptide binding]; other site
240015004083	active site
240015004084	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
240015004085	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
240015004086	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
240015004087	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
240015004088	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
240015004089	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
240015004090	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015004091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
240015004092	Putative glucoamylase; Region: Glycoamylase; pfam10091
240015004093	Cna protein B-type domain; Region: Cna_B_2; pfam13715
240015004094	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
240015004095	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
240015004096	glutaminase active site [active]
240015004097	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
240015004098	dimer interface [polypeptide binding]; other site
240015004099	active site
240015004100	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
240015004101	dimer interface [polypeptide binding]; other site
240015004102	active site
240015004103	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
240015004104	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
240015004105	dimer interface [polypeptide binding]; other site
240015004106	substrate binding site [chemical binding]; other site
240015004107	metal binding sites [ion binding]; metal-binding site
240015004108	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
240015004109	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
240015004110	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015004111	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
240015004112	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015004113	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
240015004114	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
240015004115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015004116	TPR repeat; Region: TPR_11; pfam13414
240015004117	binding surface
240015004118	TPR motif; other site
240015004119	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240015004120	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240015004121	Family description; Region: VCBS; pfam13517
240015004122	Family description; Region: VCBS; pfam13517
240015004123	Family description; Region: VCBS; pfam13517
240015004124	Family description; Region: VCBS; pfam13517
240015004125	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
240015004126	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
240015004127	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
240015004128	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240015004129	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
240015004130	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015004131	motif II; other site
240015004132	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
240015004133	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
240015004134	Rubrerythrin [Energy production and conversion]; Region: COG1592
240015004135	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
240015004136	binuclear metal center [ion binding]; other site
240015004137	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
240015004138	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
240015004139	recA bacterial DNA recombination protein; Region: RecA; cl17211
240015004140	DNA Polymerase Y-family; Region: PolY_like; cd03468
240015004141	active site
240015004142	DNA polymerase IV; Validated; Region: PRK03858
240015004143	DNA binding site [nucleotide binding]
240015004144	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
240015004145	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
240015004146	active site
240015004147	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
240015004148	generic binding surface II; other site
240015004149	generic binding surface I; other site
240015004150	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
240015004151	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015004152	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004153	FtsX-like permease family; Region: FtsX; pfam02687
240015004154	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004155	FtsX-like permease family; Region: FtsX; pfam02687
240015004156	transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433
240015004157	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015004158	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240015004159	putative active site [active]
240015004160	transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433
240015004161	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015004162	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015004163	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004164	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004165	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015004166	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004167	FtsX-like permease family; Region: FtsX; pfam02687
240015004168	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015004169	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004170	FtsX-like permease family; Region: FtsX; pfam02687
240015004171	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004172	FtsX-like permease family; Region: FtsX; pfam02687
240015004173	transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433
240015004174	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015004175	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
240015004176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
240015004177	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
240015004178	Part of AAA domain; Region: AAA_19; pfam13245
240015004179	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
240015004180	AAA domain; Region: AAA_12; pfam13087
240015004181	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
240015004182	putative active site [active]
240015004183	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
240015004184	HsdM N-terminal domain; Region: HsdM_N; pfam12161
240015004185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015004186	S-adenosylmethionine binding site [chemical binding]; other site
240015004187	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
240015004188	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
240015004189	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
240015004190	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
240015004191	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240015004192	ATP binding site [chemical binding]; other site
240015004193	putative Mg++ binding site [ion binding]; other site
240015004194	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
240015004195	hypothetical protein; Provisional; Region: PRK06153
240015004196	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
240015004197	ATP binding site [chemical binding]; other site
240015004198	substrate interface [chemical binding]; other site
240015004199	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
240015004200	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
240015004201	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
240015004202	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240015004203	Domain of unknown function (DUF955); Region: DUF955; cl01076
240015004204	HipA N-terminal domain; Region: Couple_hipA; pfam13657
240015004205	HipA-like N-terminal domain; Region: HipA_N; pfam07805
240015004206	HipA-like C-terminal domain; Region: HipA_C; pfam07804
240015004207	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015004208	non-specific DNA binding site [nucleotide binding]; other site
240015004209	salt bridge; other site
240015004210	sequence-specific DNA binding site [nucleotide binding]; other site
240015004211	Transposase; Region: HTH_Tnp_1; cl17663
240015004212	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015004213	Transcriptional regulator PadR-like family; Region: PadR; cl17335
240015004214	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015004215	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
240015004216	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
240015004217	Walker A/P-loop; other site
240015004218	ATP binding site [chemical binding]; other site
240015004219	Q-loop/lid; other site
240015004220	ABC transporter signature motif; other site
240015004221	Walker B; other site
240015004222	D-loop; other site
240015004223	H-loop/switch region; other site
240015004224	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240015004225	active site
240015004226	Int/Topo IB signature motif; other site
240015004227	DNA binding site [nucleotide binding]
240015004228	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240015004229	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK01287
240015004230	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
240015004231	putative active site [active]
240015004232	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
240015004233	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
240015004234	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
240015004235	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
240015004236	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
240015004237	Protein export membrane protein; Region: SecD_SecF; cl14618
240015004238	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015004239	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
240015004240	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015004241	Outer membrane efflux protein; Region: OEP; pfam02321
240015004242	Outer membrane efflux protein; Region: OEP; pfam02321
240015004243	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240015004244	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
240015004245	PAS domain; Region: PAS; smart00091
240015004246	putative active site [active]
240015004247	heme pocket [chemical binding]; other site
240015004248	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015004249	ATP binding site [chemical binding]; other site
240015004250	Mg2+ binding site [ion binding]; other site
240015004251	G-X-G motif; other site
240015004252	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015004253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015004254	active site
240015004255	phosphorylation site [posttranslational modification]
240015004256	intermolecular recognition site; other site
240015004257	dimerization interface [polypeptide binding]; other site
240015004258	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015004259	DNA binding residues [nucleotide binding]
240015004260	dimerization interface [polypeptide binding]; other site
240015004261	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015004262	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004263	FtsX-like permease family; Region: FtsX; pfam02687
240015004264	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004265	FtsX-like permease family; Region: FtsX; pfam02687
240015004266	transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433
240015004267	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015004268	Fic family protein [Function unknown]; Region: COG3177
240015004269	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
240015004270	Fic/DOC family; Region: Fic; pfam02661
240015004271	putative transposase OrfB; Reviewed; Region: PHA02517
240015004272	HTH-like domain; Region: HTH_21; pfam13276
240015004273	Integrase core domain; Region: rve; pfam00665
240015004274	Integrase core domain; Region: rve_3; pfam13683
240015004275	Transposase; Region: HTH_Tnp_1; pfam01527
240015004276	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
240015004277	active site
240015004278	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
240015004279	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240015004280	Ligand Binding Site [chemical binding]; other site
240015004281	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240015004282	Ligand Binding Site [chemical binding]; other site
240015004283	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
240015004284	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
240015004285	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
240015004286	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
240015004287	catalytic core [active]
240015004288	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
240015004289	Uncharacterized conserved protein [Function unknown]; Region: COG3391
240015004290	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
240015004291	structural tetrad; other site
240015004292	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
240015004293	Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397
240015004294	alpha-galactosidase; Region: PLN02808; cl17638
240015004295	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
240015004296	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
240015004297	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
240015004298	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
240015004299	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
240015004300	active site
240015004301	dimer interface [polypeptide binding]; other site
240015004302	effector binding site; other site
240015004303	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
240015004304	TSCPD domain; Region: TSCPD; pfam12637
240015004305	Predicted transcriptional regulators [Transcription]; Region: COG1733
240015004306	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
240015004307	short chain dehydrogenase; Provisional; Region: PRK06197
240015004308	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
240015004309	putative NAD(P) binding site [chemical binding]; other site
240015004310	active site
240015004311	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240015004312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015004313	TPR motif; other site
240015004314	binding surface
240015004315	TPR repeat; Region: TPR_11; pfam13414
240015004316	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015004317	TPR motif; other site
240015004318	binding surface
240015004319	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015004320	binding surface
240015004321	TPR motif; other site
240015004322	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015004323	binding surface
240015004324	TPR motif; other site
240015004325	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015004326	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015004327	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015004328	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
240015004329	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015004330	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015004331	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004332	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
240015004333	FtsX-like permease family; Region: FtsX; pfam02687
240015004334	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004335	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
240015004336	FtsX-like permease family; Region: FtsX; pfam02687
240015004337	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240015004338	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240015004339	Walker A/P-loop; other site
240015004340	ATP binding site [chemical binding]; other site
240015004341	Q-loop/lid; other site
240015004342	ABC transporter signature motif; other site
240015004343	Walker B; other site
240015004344	D-loop; other site
240015004345	H-loop/switch region; other site
240015004346	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
240015004347	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
240015004348	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
240015004349	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
240015004350	putative active site [active]
240015004351	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
240015004352	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
240015004353	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
240015004354	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
240015004355	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
240015004356	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240015004357	catalytic residue [active]
240015004358	RIP metalloprotease RseP; Region: TIGR00054
240015004359	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
240015004360	active site
240015004361	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
240015004362	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
240015004363	protein binding site [polypeptide binding]; other site
240015004364	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
240015004365	putative substrate binding region [chemical binding]; other site
240015004366	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
240015004367	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
240015004368	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
240015004369	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
240015004370	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
240015004371	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
240015004372	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240015004373	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
240015004374	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
240015004375	HIGH motif; other site
240015004376	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
240015004377	active site
240015004378	KMSKS motif; other site
240015004379	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
240015004380	homotrimer interaction site [polypeptide binding]; other site
240015004381	zinc binding site [ion binding]; other site
240015004382	CDP-binding sites; other site
240015004383	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
240015004384	substrate binding site; other site
240015004385	dimer interface; other site
240015004386	amidase; Provisional; Region: PRK06529
240015004387	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
240015004388	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
240015004389	Rossmann-like domain; Region: Rossmann-like; pfam10727
240015004390	Uncharacterized conserved protein [Function unknown]; Region: COG5495
240015004391	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
240015004392	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
240015004393	dimer interface [polypeptide binding]; other site
240015004394	ADP-ribose binding site [chemical binding]; other site
240015004395	active site
240015004396	nudix motif; other site
240015004397	metal binding site [ion binding]; metal-binding site
240015004398	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
240015004399	DNA-binding site [nucleotide binding]; DNA binding site
240015004400	RNA-binding motif; other site
240015004401	hypothetical protein; Provisional; Region: PRK08609
240015004402	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
240015004403	active site
240015004404	primer binding site [nucleotide binding]; other site
240015004405	NTP  binding site [chemical binding]; other site
240015004406	metal binding triad [ion binding]; metal-binding site
240015004407	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
240015004408	active site
240015004409	Preprotein translocase subunit SecF [Intracellular trafficking and secretion]; Region: SecF; COG0341
240015004410	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
240015004411	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
240015004412	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
240015004413	catalytic residue [active]
240015004414	putative FPP diphosphate  binding site; other site
240015004415	putative FPP binding hydrophobic cleft; other site
240015004416	dimer interface [polypeptide binding]; other site
240015004417	putative IPP diphosphate binding site; other site
240015004418	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
240015004419	IHF dimer interface [polypeptide binding]; other site
240015004420	IHF - DNA interface [nucleotide binding]; other site
240015004421	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
240015004422	Ligand binding site; other site
240015004423	Ligand binding site; other site
240015004424	Ligand binding site; other site
240015004425	Putative Catalytic site; other site
240015004426	DXD motif; other site
240015004427	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
240015004428	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
240015004429	Walker A/P-loop; other site
240015004430	ATP binding site [chemical binding]; other site
240015004431	Q-loop/lid; other site
240015004432	ABC transporter signature motif; other site
240015004433	Walker B; other site
240015004434	D-loop; other site
240015004435	H-loop/switch region; other site
240015004436	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
240015004437	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015004438	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
240015004439	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015004440	dimer interface [polypeptide binding]; other site
240015004441	phosphorylation site [posttranslational modification]
240015004442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015004443	ATP binding site [chemical binding]; other site
240015004444	Mg2+ binding site [ion binding]; other site
240015004445	G-X-G motif; other site
240015004446	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
240015004447	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
240015004448	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
240015004449	active site
240015004450	catalytic site [active]
240015004451	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
240015004452	Predicted transcriptional regulator [Transcription]; Region: COG2944
240015004453	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015004454	non-specific DNA binding site [nucleotide binding]; other site
240015004455	salt bridge; other site
240015004456	sequence-specific DNA binding site [nucleotide binding]; other site
240015004457	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
240015004458	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015004459	FeS/SAM binding site; other site
240015004460	Protein of unknown function, DUF481; Region: DUF481; cl01213
240015004461	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
240015004462	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
240015004463	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240015004464	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
240015004465	active site
240015004466	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
240015004467	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
240015004468	Ligand Binding Site [chemical binding]; other site
240015004469	GTP-binding protein Der; Reviewed; Region: PRK00093
240015004470	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
240015004471	G1 box; other site
240015004472	GTP/Mg2+ binding site [chemical binding]; other site
240015004473	Switch I region; other site
240015004474	G2 box; other site
240015004475	Switch II region; other site
240015004476	G3 box; other site
240015004477	G4 box; other site
240015004478	G5 box; other site
240015004479	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
240015004480	G1 box; other site
240015004481	GTP/Mg2+ binding site [chemical binding]; other site
240015004482	Switch I region; other site
240015004483	G2 box; other site
240015004484	G3 box; other site
240015004485	Switch II region; other site
240015004486	G4 box; other site
240015004487	G5 box; other site
240015004488	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
240015004489	oligomeric interface; other site
240015004490	putative active site [active]
240015004491	homodimer interface [polypeptide binding]; other site
240015004492	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
240015004493	DEAD/DEAH box helicase; Region: DEAD; pfam00270
240015004494	DEAD_2; Region: DEAD_2; pfam06733
240015004495	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
240015004496	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
240015004497	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
240015004498	active site
240015004499	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
240015004500	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
240015004501	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
240015004502	substrate binding pocket [chemical binding]; other site
240015004503	chain length determination region; other site
240015004504	substrate-Mg2+ binding site; other site
240015004505	catalytic residues [active]
240015004506	aspartate-rich region 1; other site
240015004507	active site lid residues [active]
240015004508	aspartate-rich region 2; other site
240015004509	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
240015004510	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
240015004511	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
240015004512	active site
240015004513	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
240015004514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015004515	motif II; other site
240015004516	enoyl-CoA hydratase; Provisional; Region: PRK05995
240015004517	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
240015004518	substrate binding site [chemical binding]; other site
240015004519	oxyanion hole (OAH) forming residues; other site
240015004520	trimer interface [polypeptide binding]; other site
240015004521	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
240015004522	active site
240015004523	catalytic residues [active]
240015004524	metal binding site [ion binding]; metal-binding site
240015004525	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
240015004526	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
240015004527	trimer interface [polypeptide binding]; other site
240015004528	oxyanion hole (OAH) forming residues; other site
240015004529	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
240015004530	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
240015004531	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
240015004532	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240015004533	dimerization interface [polypeptide binding]; other site
240015004534	putative DNA binding site [nucleotide binding]; other site
240015004535	putative Zn2+ binding site [ion binding]; other site
240015004536	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
240015004537	putative hydrophobic ligand binding site [chemical binding]; other site
240015004538	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
240015004539	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015004540	non-specific DNA binding site [nucleotide binding]; other site
240015004541	salt bridge; other site
240015004542	sequence-specific DNA binding site [nucleotide binding]; other site
240015004543	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
240015004544	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
240015004545	RNA binding site [nucleotide binding]; other site
240015004546	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
240015004547	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
240015004548	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
240015004549	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
240015004550	KpsF/GutQ family protein; Region: kpsF; TIGR00393
240015004551	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
240015004552	putative active site [active]
240015004553	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
240015004554	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
240015004555	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240015004556	catalytic residues [active]
240015004557	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
240015004558	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
240015004559	DNA binding residues [nucleotide binding]
240015004560	dimerization interface [polypeptide binding]; other site
240015004561	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
240015004562	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
240015004563	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
240015004564	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
240015004565	rod shape-determining protein MreC; Provisional; Region: PRK13922
240015004566	rod shape-determining protein MreC; Region: MreC; pfam04085
240015004567	rod shape-determining protein MreB; Provisional; Region: PRK13927
240015004568	MreB and similar proteins; Region: MreB_like; cd10225
240015004569	nucleotide binding site [chemical binding]; other site
240015004570	Mg binding site [ion binding]; other site
240015004571	putative protofilament interaction site [polypeptide binding]; other site
240015004572	RodZ interaction site [polypeptide binding]; other site
240015004573	Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131
240015004574	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
240015004575	NAD binding site [chemical binding]; other site
240015004576	catalytic residues [active]
240015004577	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
240015004578	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
240015004579	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
240015004580	hexamer interface [polypeptide binding]; other site
240015004581	ligand binding site [chemical binding]; other site
240015004582	putative active site [active]
240015004583	NAD(P) binding site [chemical binding]; other site
240015004584	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
240015004585	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240015004586	dimerization interface [polypeptide binding]; other site
240015004587	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015004588	dimer interface [polypeptide binding]; other site
240015004589	phosphorylation site [posttranslational modification]
240015004590	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015004591	ATP binding site [chemical binding]; other site
240015004592	Mg2+ binding site [ion binding]; other site
240015004593	G-X-G motif; other site
240015004594	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
240015004595	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015004596	active site
240015004597	phosphorylation site [posttranslational modification]
240015004598	intermolecular recognition site; other site
240015004599	dimerization interface [polypeptide binding]; other site
240015004600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015004601	Walker A motif; other site
240015004602	ATP binding site [chemical binding]; other site
240015004603	Walker B motif; other site
240015004604	arginine finger; other site
240015004605	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
240015004606	MT-A70; Region: MT-A70; cl01947
240015004607	Homeodomain-like domain; Region: HTH_23; cl17451
240015004608	Integrase core domain; Region: rve; pfam00665
240015004609	Integrase core domain; Region: rve_3; pfam13683
240015004610	GTPase Era; Reviewed; Region: era; PRK00089
240015004611	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
240015004612	G1 box; other site
240015004613	GTP/Mg2+ binding site [chemical binding]; other site
240015004614	Switch I region; other site
240015004615	G2 box; other site
240015004616	Switch II region; other site
240015004617	G3 box; other site
240015004618	G4 box; other site
240015004619	G5 box; other site
240015004620	KH domain; Region: KH_2; pfam07650
240015004621	FOG: CBS domain [General function prediction only]; Region: COG0517
240015004622	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
240015004623	Transporter associated domain; Region: CorC_HlyC; smart01091
240015004624	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
240015004625	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
240015004626	PhoH-like protein; Region: PhoH; pfam02562
240015004627	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004628	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015004629	FtsX-like permease family; Region: FtsX; pfam02687
240015004630	transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433
240015004631	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015004632	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
240015004633	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015004634	S-adenosylmethionine binding site [chemical binding]; other site
240015004635	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
240015004636	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240015004637	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
240015004638	putative heme binding pocket [chemical binding]; other site
240015004639	Ion channel; Region: Ion_trans_2; pfam07885
240015004640	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
240015004641	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
240015004642	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
240015004643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240015004644	TPR motif; other site
240015004645	binding surface
240015004646	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
240015004647	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
240015004648	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240015004649	metal ion-dependent adhesion site (MIDAS); other site
240015004650	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
240015004651	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
240015004652	putative DNA binding site [nucleotide binding]; other site
240015004653	catalytic residue [active]
240015004654	putative H2TH interface [polypeptide binding]; other site
240015004655	putative catalytic residues [active]
240015004656	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
240015004657	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240015004658	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
240015004659	ATP binding site [chemical binding]; other site
240015004660	putative Mg++ binding site [ion binding]; other site
240015004661	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240015004662	nucleotide binding region [chemical binding]; other site
240015004663	ATP-binding site [chemical binding]; other site
240015004664	DEAD/H associated; Region: DEAD_assoc; pfam08494
240015004665	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
240015004666	active site
240015004667	catalytic motif [active]
240015004668	Zn binding site [ion binding]; other site
240015004669	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
240015004670	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
240015004671	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
240015004672	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
240015004673	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
240015004674	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
240015004675	Nucleoside recognition; Region: Gate; pfam07670
240015004676	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
240015004677	purine nucleoside phosphorylase; Provisional; Region: PRK08202
240015004678	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
240015004679	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
240015004680	ATP-binding site [chemical binding]; other site
240015004681	Sugar specificity; other site
240015004682	Pyrimidine base specificity; other site
240015004683	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
240015004684	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240015004685	DXD motif; other site
240015004686	DoxX; Region: DoxX; pfam07681
240015004687	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
240015004688	classical (c) SDRs; Region: SDR_c; cd05233
240015004689	NAD(P) binding site [chemical binding]; other site
240015004690	active site
240015004691	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
240015004692	Zn binding site [ion binding]; other site
240015004693	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
240015004694	deoxyhypusine synthase; Region: dhys; TIGR00321
240015004695	Response regulator receiver domain; Region: Response_reg; pfam00072
240015004696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015004697	active site
240015004698	phosphorylation site [posttranslational modification]
240015004699	intermolecular recognition site; other site
240015004700	dimerization interface [polypeptide binding]; other site
240015004701	Ion channel; Region: Ion_trans_2; pfam07885
240015004702	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
240015004703	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
240015004704	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
240015004705	generic binding surface II; other site
240015004706	generic binding surface I; other site
240015004707	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
240015004708	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
240015004709	active site
240015004710	substrate binding site [chemical binding]; other site
240015004711	metal binding site [ion binding]; metal-binding site
240015004712	5'-3' exonuclease; Region: 53EXOc; smart00475
240015004713	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
240015004714	active site
240015004715	metal binding site 1 [ion binding]; metal-binding site
240015004716	putative 5' ssDNA interaction site; other site
240015004717	metal binding site 3; metal-binding site
240015004718	metal binding site 2 [ion binding]; metal-binding site
240015004719	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
240015004720	putative DNA binding site [nucleotide binding]; other site
240015004721	putative metal binding site [ion binding]; other site
240015004722	DNA polymerase I; Provisional; Region: PRK05755
240015004723	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
240015004724	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
240015004725	active site
240015004726	DNA binding site [nucleotide binding]
240015004727	catalytic site [active]
240015004728	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
240015004729	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
240015004730	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
240015004731	putative acyl-acceptor binding pocket; other site
240015004732	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
240015004733	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
240015004734	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015004735	Walker A/P-loop; other site
240015004736	ATP binding site [chemical binding]; other site
240015004737	Q-loop/lid; other site
240015004738	ABC transporter signature motif; other site
240015004739	Walker B; other site
240015004740	D-loop; other site
240015004741	H-loop/switch region; other site
240015004742	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
240015004743	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
240015004744	ssDNA binding site; other site
240015004745	generic binding surface II; other site
240015004746	DEAD-like helicases superfamily; Region: DEXDc; smart00487
240015004747	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240015004748	ATP binding site [chemical binding]; other site
240015004749	putative Mg++ binding site [ion binding]; other site
240015004750	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240015004751	ATP-binding site [chemical binding]; other site
240015004752	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
240015004753	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
240015004754	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
240015004755	putative active site; other site
240015004756	catalytic triad [active]
240015004757	putative dimer interface [polypeptide binding]; other site
240015004758	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
240015004759	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
240015004760	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
240015004761	nucleoside/Zn binding site; other site
240015004762	dimer interface [polypeptide binding]; other site
240015004763	catalytic motif [active]
240015004764	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
240015004765	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
240015004766	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
240015004767	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
240015004768	N-acetyl-D-glucosamine binding site [chemical binding]; other site
240015004769	catalytic residue [active]
240015004770	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
240015004771	hypothetical protein; Reviewed; Region: PRK12497
240015004772	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
240015004773	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
240015004774	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
240015004775	Family description; Region: VCBS; pfam13517
240015004776	Family description; Region: VCBS; pfam13517
240015004777	Family description; Region: VCBS; pfam13517
240015004778	Family description; Region: VCBS; pfam13517
240015004779	Family description; Region: VCBS; pfam13517
240015004780	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
240015004781	TPR repeat; Region: TPR_11; pfam13414
240015004782	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015004783	binding surface
240015004784	TPR motif; other site
240015004785	TPR repeat; Region: TPR_11; pfam13414
240015004786	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015004787	TPR motif; other site
240015004788	binding surface
240015004789	TPR repeat; Region: TPR_11; pfam13414
240015004790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015004791	binding surface
240015004792	TPR motif; other site
240015004793	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015004794	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015004795	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240015004796	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240015004797	metal ion-dependent adhesion site (MIDAS); other site
240015004798	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240015004799	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240015004800	metal ion-dependent adhesion site (MIDAS); other site
240015004801	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
240015004802	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
240015004803	putative NAD(P) binding site [chemical binding]; other site
240015004804	putative substrate binding site [chemical binding]; other site
240015004805	catalytic Zn binding site [ion binding]; other site
240015004806	structural Zn binding site [ion binding]; other site
240015004807	dimer interface [polypeptide binding]; other site
240015004808	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
240015004809	diiron binding motif [ion binding]; other site
240015004810	VIT family; Region: VIT1; pfam01988
240015004811	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
240015004812	prephenate dehydrogenase; Validated; Region: PRK08507
240015004813	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
240015004814	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
240015004815	Chorismate mutase type II; Region: CM_2; pfam01817
240015004816	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
240015004817	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
240015004818	substrate binding site [chemical binding]; other site
240015004819	active site
240015004820	catalytic residues [active]
240015004821	heterodimer interface [polypeptide binding]; other site
240015004822	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
240015004823	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
240015004824	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015004825	catalytic residue [active]
240015004826	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
240015004827	active site
240015004828	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
240015004829	active site
240015004830	ribulose/triose binding site [chemical binding]; other site
240015004831	phosphate binding site [ion binding]; other site
240015004832	substrate (anthranilate) binding pocket [chemical binding]; other site
240015004833	product (indole) binding pocket [chemical binding]; other site
240015004834	Yip1 domain; Region: Yip1; pfam04893
240015004835	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
240015004836	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
240015004837	dimer interface [polypeptide binding]; other site
240015004838	active site
240015004839	acyl carrier protein; Provisional; Region: acpP; PRK00982
240015004840	RmuC family; Region: RmuC; pfam02646
240015004841	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
240015004842	nucleotide binding site/active site [active]
240015004843	HIT family signature motif; other site
240015004844	catalytic residue [active]
240015004845	AAA ATPase domain; Region: AAA_16; pfam13191
240015004846	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
240015004847	NodB motif; other site
240015004848	putative active site [active]
240015004849	putative catalytic site [active]
240015004850	putative Zn binding site [ion binding]; other site
240015004851	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
240015004852	S-adenosylmethionine synthetase; Validated; Region: PRK05250
240015004853	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
240015004854	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
240015004855	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
240015004856	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015004857	dimer interface [polypeptide binding]; other site
240015004858	phosphorylation site [posttranslational modification]
240015004859	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015004860	ATP binding site [chemical binding]; other site
240015004861	Mg2+ binding site [ion binding]; other site
240015004862	G-X-G motif; other site
240015004863	recombination regulator RecX; Reviewed; Region: recX; PRK00117
240015004864	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
240015004865	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
240015004866	dimer interface [polypeptide binding]; other site
240015004867	Citrate synthase; Region: Citrate_synt; pfam00285
240015004868	active site
240015004869	citrylCoA binding site [chemical binding]; other site
240015004870	oxalacetate/citrate binding site [chemical binding]; other site
240015004871	coenzyme A binding site [chemical binding]; other site
240015004872	catalytic triad [active]
240015004873	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
240015004874	classical (c) SDRs; Region: SDR_c; cd05233
240015004875	NAD(P) binding site [chemical binding]; other site
240015004876	active site
240015004877	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
240015004878	Part of AAA domain; Region: AAA_19; pfam13245
240015004879	AAA domain; Region: AAA_14; pfam13173
240015004880	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
240015004881	Family description; Region: UvrD_C_2; pfam13538
240015004882	amino acid transporter; Region: 2A0306; TIGR00909
240015004883	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
240015004884	Protein of unknown function (DUF419); Region: DUF419; cl15265
240015004885	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240015004886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015004887	NAD(P) binding site [chemical binding]; other site
240015004888	active site
240015004889	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
240015004890	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
240015004891	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
240015004892	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
240015004893	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
240015004894	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
240015004895	Active Sites [active]
240015004896	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
240015004897	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
240015004898	CysD dimerization site [polypeptide binding]; other site
240015004899	G1 box; other site
240015004900	putative GEF interaction site [polypeptide binding]; other site
240015004901	GTP/Mg2+ binding site [chemical binding]; other site
240015004902	Switch I region; other site
240015004903	G2 box; other site
240015004904	G3 box; other site
240015004905	Switch II region; other site
240015004906	G4 box; other site
240015004907	G5 box; other site
240015004908	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
240015004909	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
240015004910	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
240015004911	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
240015004912	Active Sites [active]
240015004913	methionine sulfoxide reductase B; Provisional; Region: PRK00222
240015004914	SelR domain; Region: SelR; pfam01641
240015004915	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
240015004916	homotrimer interaction site [polypeptide binding]; other site
240015004917	putative active site [active]
240015004918	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240015004919	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240015004920	metal ion-dependent adhesion site (MIDAS); other site
240015004921	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
240015004922	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
240015004923	nucleotide binding pocket [chemical binding]; other site
240015004924	K-X-D-G motif; other site
240015004925	catalytic site [active]
240015004926	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
240015004927	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
240015004928	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
240015004929	DNA binding site [nucleotide binding]
240015004930	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
240015004931	Dimer interface [polypeptide binding]; other site
240015004932	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
240015004933	peptidase domain interface [polypeptide binding]; other site
240015004934	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
240015004935	active site
240015004936	catalytic triad [active]
240015004937	calcium binding site [ion binding]; other site
240015004938	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
240015004939	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
240015004940	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
240015004941	DNA polymerase IV; Reviewed; Region: PRK03103
240015004942	Y-family of DNA polymerases; Region: PolY; cd00424
240015004943	active site
240015004944	DNA binding site [nucleotide binding]
240015004945	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
240015004946	CsbD-like; Region: CsbD; pfam05532
240015004947	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
240015004948	active site
240015004949	HIGH motif; other site
240015004950	nucleotide binding site [chemical binding]; other site
240015004951	active site
240015004952	KMSKS motif; other site
240015004953	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
240015004954	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
240015004955	CHC2 zinc finger; Region: zf-CHC2; pfam01807
240015004956	DNA primase; Validated; Region: dnaG; PRK05667
240015004957	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
240015004958	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
240015004959	active site
240015004960	metal binding site [ion binding]; metal-binding site
240015004961	interdomain interaction site; other site
240015004962	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
240015004963	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
240015004964	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015004965	Walker A motif; other site
240015004966	ATP binding site [chemical binding]; other site
240015004967	Walker B motif; other site
240015004968	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
240015004969	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
240015004970	active site
240015004971	dimer interface [polypeptide binding]; other site
240015004972	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
240015004973	Ligand Binding Site [chemical binding]; other site
240015004974	Molecular Tunnel; other site
240015004975	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
240015004976	DinB family; Region: DinB; cl17821
240015004977	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
240015004978	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642
240015004979	Peptidase family M28; Region: Peptidase_M28; pfam04389
240015004980	putative metal binding site [ion binding]; other site
240015004981	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
240015004982	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015004983	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
240015004984	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
240015004985	trimer interface [polypeptide binding]; other site
240015004986	putative metal binding site [ion binding]; other site
240015004987	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
240015004988	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
240015004989	dimer interface [polypeptide binding]; other site
240015004990	motif 1; other site
240015004991	active site
240015004992	motif 2; other site
240015004993	motif 3; other site
240015004994	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
240015004995	four helix bundle protein; Region: TIGR02436
240015004996	Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072
240015004997	B3/4 domain; Region: B3_4; pfam03483
240015004998	tRNA synthetase B5 domain; Region: B5; pfam03484
240015004999	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
240015005000	dimer interface [polypeptide binding]; other site
240015005001	motif 1; other site
240015005002	motif 3; other site
240015005003	motif 2; other site
240015005004	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
240015005005	Cell division protein ZapA; Region: ZapA; pfam05164
240015005006	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
240015005007	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
240015005008	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
240015005009	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240015005010	RNA binding surface [nucleotide binding]; other site
240015005011	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
240015005012	active site
240015005013	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
240015005014	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
240015005015	Fatty acid desaturase; Region: FA_desaturase; pfam00487
240015005016	Di-iron ligands [ion binding]; other site
240015005017	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
240015005018	Uncharacterized conserved protein [Function unknown]; Region: COG2128
240015005019	HI0933-like protein; Region: HI0933_like; pfam03486
240015005020	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240015005021	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
240015005022	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
240015005023	trimer interface [polypeptide binding]; other site
240015005024	dimer interface [polypeptide binding]; other site
240015005025	putative active site [active]
240015005026	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
240015005027	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
240015005028	dimer interface [polypeptide binding]; other site
240015005029	putative functional site; other site
240015005030	putative MPT binding site; other site
240015005031	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015005032	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
240015005033	Ligand Binding Site [chemical binding]; other site
240015005034	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
240015005035	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
240015005036	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
240015005037	Sulfate transporter family; Region: Sulfate_transp; pfam00916
240015005038	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
240015005039	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
240015005040	Glucose inhibited division protein A; Region: GIDA; pfam01134
240015005041	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015005042	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
240015005043	FtsX-like permease family; Region: FtsX; pfam02687
240015005044	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
240015005045	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
240015005046	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
240015005047	B12 binding site [chemical binding]; other site
240015005048	Radical SAM superfamily; Region: Radical_SAM; pfam04055
240015005049	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015005050	FeS/SAM binding site; other site
240015005051	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
240015005052	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240015005053	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015005054	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015005055	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015005056	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
240015005057	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
240015005058	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
240015005059	Bacterial sugar transferase; Region: Bac_transf; pfam02397
240015005060	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
240015005061	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
240015005062	NADP binding site [chemical binding]; other site
240015005063	active site
240015005064	putative substrate binding site [chemical binding]; other site
240015005065	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
240015005066	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
240015005067	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
240015005068	substrate binding site; other site
240015005069	tetramer interface; other site
240015005070	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
240015005071	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
240015005072	NAD binding site [chemical binding]; other site
240015005073	substrate binding site [chemical binding]; other site
240015005074	homodimer interface [polypeptide binding]; other site
240015005075	active site
240015005076	Chain length determinant protein; Region: Wzz; cl15801
240015005077	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
240015005078	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
240015005079	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
240015005080	SLBB domain; Region: SLBB; pfam10531
240015005081	SLBB domain; Region: SLBB; pfam10531
240015005082	SLBB domain; Region: SLBB; pfam10531
240015005083	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
240015005084	photolyase PhrII; Region: phr2; TIGR00591
240015005085	DNA photolyase; Region: DNA_photolyase; pfam00875
240015005086	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
240015005087	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
240015005088	NAD(P) binding site [chemical binding]; other site
240015005089	catalytic residues [active]
240015005090	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
240015005091	endonuclease III; Region: ENDO3c; smart00478
240015005092	minor groove reading motif; other site
240015005093	helix-hairpin-helix signature motif; other site
240015005094	substrate binding pocket [chemical binding]; other site
240015005095	active site
240015005096	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
240015005097	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
240015005098	active site
240015005099	catalytic site [active]
240015005100	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
240015005101	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
240015005102	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
240015005103	[2Fe-2S] cluster binding site [ion binding]; other site
240015005104	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
240015005105	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
240015005106	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240015005107	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
240015005108	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
240015005109	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
240015005110	domain interfaces; other site
240015005111	active site
240015005112	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
240015005113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015005114	ATP binding site [chemical binding]; other site
240015005115	Mg2+ binding site [ion binding]; other site
240015005116	G-X-G motif; other site
240015005117	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
240015005118	ATP binding site [chemical binding]; other site
240015005119	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
240015005120	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
240015005121	cytidylate kinase; Provisional; Region: cmk; PRK00023
240015005122	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
240015005123	CMP-binding site; other site
240015005124	The sites determining sugar specificity; other site
240015005125	B-box zinc finger; Region: zf-B_box; pfam00643
240015005126	Putative zinc-finger; Region: zf-HC2; pfam13490
240015005127	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
240015005128	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015005129	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015005130	DNA binding residues [nucleotide binding]
240015005131	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
240015005132	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
240015005133	ligand binding site; other site
240015005134	oligomer interface; other site
240015005135	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
240015005136	dimer interface [polypeptide binding]; other site
240015005137	N-terminal domain interface [polypeptide binding]; other site
240015005138	sulfate 1 binding site; other site
240015005139	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
240015005140	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
240015005141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015005142	D-galactonate transporter; Region: 2A0114; TIGR00893
240015005143	putative substrate translocation pore; other site
240015005144	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
240015005145	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
240015005146	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
240015005147	glutamate carboxypeptidase; Reviewed; Region: PRK06133
240015005148	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
240015005149	metal binding site [ion binding]; metal-binding site
240015005150	dimer interface [polypeptide binding]; other site
240015005151	Maf-like protein; Region: Maf; pfam02545
240015005152	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
240015005153	active site
240015005154	dimer interface [polypeptide binding]; other site
240015005155	ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702
240015005156	catalytic nucleophile [active]
240015005157	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
240015005158	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240015005159	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
240015005160	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
240015005161	MPT binding site; other site
240015005162	trimer interface [polypeptide binding]; other site
240015005163	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
240015005164	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
240015005165	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
240015005166	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
240015005167	substrate-cofactor binding pocket; other site
240015005168	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015005169	catalytic residue [active]
240015005170	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
240015005171	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
240015005172	active site
240015005173	Zn binding site [ion binding]; other site
240015005174	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015005175	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015005176	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015005177	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
240015005178	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015005179	TPR repeat; Region: TPR_11; pfam13414
240015005180	binding surface
240015005181	TPR motif; other site
240015005182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015005183	binding surface
240015005184	TPR motif; other site
240015005185	TPR repeat; Region: TPR_11; pfam13414
240015005186	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
240015005187	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
240015005188	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
240015005189	dimer interface [polypeptide binding]; other site
240015005190	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240015005191	ligand binding site [chemical binding]; other site
240015005192	putative phosphate acyltransferase; Provisional; Region: PRK05331
240015005193	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
240015005194	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
240015005195	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
240015005196	FAD binding domain; Region: FAD_binding_4; pfam01565
240015005197	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
240015005198	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
240015005199	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
240015005200	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
240015005201	Amidase; Region: Amidase; cl11426
240015005202	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
240015005203	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
240015005204	Walker A/P-loop; other site
240015005205	ATP binding site [chemical binding]; other site
240015005206	Q-loop/lid; other site
240015005207	ABC transporter signature motif; other site
240015005208	Walker B; other site
240015005209	D-loop; other site
240015005210	H-loop/switch region; other site
240015005211	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
240015005212	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
240015005213	hypothetical protein; Provisional; Region: PRK10621
240015005214	Uncharacterized conserved protein [Function unknown]; Region: COG4095
240015005215	Protein of unknown function (DUF971); Region: DUF971; pfam06155
240015005216	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
240015005217	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
240015005218	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
240015005219	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
240015005220	DNA interaction; other site
240015005221	Metal-binding active site; metal-binding site
240015005222	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
240015005223	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
240015005224	hypothetical protein; Provisional; Region: PRK07236
240015005225	TetR family transcriptional regulator; Provisional; Region: PRK14996
240015005226	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015005227	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240015005228	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
240015005229	active site residue [active]
240015005230	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
240015005231	active site residue [active]
240015005232	Predicted transcriptional regulators [Transcription]; Region: COG1733
240015005233	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
240015005234	DinB family; Region: DinB; cl17821
240015005235	DinB superfamily; Region: DinB_2; pfam12867
240015005236	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
240015005237	dimer interface [polypeptide binding]; other site
240015005238	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
240015005239	dimer interface [polypeptide binding]; other site
240015005240	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240015005241	BNR repeat-like domain; Region: BNR_2; pfam13088
240015005242	Cation efflux family; Region: Cation_efflux; cl00316
240015005243	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
240015005244	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
240015005245	FAD binding pocket [chemical binding]; other site
240015005246	conserved FAD binding motif [chemical binding]; other site
240015005247	phosphate binding motif [ion binding]; other site
240015005248	beta-alpha-beta structure motif; other site
240015005249	NAD binding pocket [chemical binding]; other site
240015005250	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
240015005251	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
240015005252	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
240015005253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
240015005254	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
240015005255	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
240015005256	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
240015005257	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240015005258	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
240015005259	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015005260	non-specific DNA binding site [nucleotide binding]; other site
240015005261	salt bridge; other site
240015005262	sequence-specific DNA binding site [nucleotide binding]; other site
240015005263	Membrane protein of unknown function; Region: DUF360; pfam04020
240015005264	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015005265	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015005266	metal binding site [ion binding]; metal-binding site
240015005267	active site
240015005268	I-site; other site
240015005269	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
240015005270	AMIN domain; Region: AMIN; pfam11741
240015005271	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
240015005272	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
240015005273	active site
240015005274	metal binding site [ion binding]; metal-binding site
240015005275	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
240015005276	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
240015005277	motif 1; other site
240015005278	active site
240015005279	motif 2; other site
240015005280	motif 3; other site
240015005281	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
240015005282	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
240015005283	protein binding site [polypeptide binding]; other site
240015005284	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240015005285	GAF domain; Region: GAF_3; pfam13492
240015005286	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
240015005287	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
240015005288	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240015005289	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
240015005290	active site
240015005291	metal binding site [ion binding]; metal-binding site
240015005292	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
240015005293	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
240015005294	active site
240015005295	metal binding site [ion binding]; metal-binding site
240015005296	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
240015005297	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
240015005298	homodimer interface [polypeptide binding]; other site
240015005299	active site
240015005300	TDP-binding site; other site
240015005301	acceptor substrate-binding pocket; other site
240015005302	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
240015005303	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
240015005304	active site
240015005305	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
240015005306	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
240015005307	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
240015005308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015005309	putative substrate translocation pore; other site
240015005310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015005311	CHASE3 domain; Region: CHASE3; pfam05227
240015005312	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015005313	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240015005314	putative active site [active]
240015005315	heme pocket [chemical binding]; other site
240015005316	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015005317	dimer interface [polypeptide binding]; other site
240015005318	phosphorylation site [posttranslational modification]
240015005319	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015005320	ATP binding site [chemical binding]; other site
240015005321	Mg2+ binding site [ion binding]; other site
240015005322	G-X-G motif; other site
240015005323	oxidative damage protection protein; Provisional; Region: PRK05408
240015005324	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
240015005325	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
240015005326	NodB motif; other site
240015005327	active site
240015005328	catalytic site [active]
240015005329	metal binding site [ion binding]; metal-binding site
240015005330	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
240015005331	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240015005332	protein binding site [polypeptide binding]; other site
240015005333	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
240015005334	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
240015005335	CoA-binding site [chemical binding]; other site
240015005336	ATP-binding [chemical binding]; other site
240015005337	Trm112p-like protein; Region: Trm112p; cl01066
240015005338	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
240015005339	intracellular protease, PfpI family; Region: PfpI; TIGR01382
240015005340	conserved cys residue [active]
240015005341	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
240015005342	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
240015005343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015005344	Walker A motif; other site
240015005345	ATP binding site [chemical binding]; other site
240015005346	Walker B motif; other site
240015005347	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
240015005348	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015005349	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015005350	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
240015005351	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015005352	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015005353	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015005354	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
240015005355	Outer membrane efflux protein; Region: OEP; pfam02321
240015005356	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
240015005357	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015005358	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015005359	DNA binding residues [nucleotide binding]
240015005360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015005361	Walker A/P-loop; other site
240015005362	ATP binding site [chemical binding]; other site
240015005363	Q-loop/lid; other site
240015005364	ABC transporter signature motif; other site
240015005365	Walker B; other site
240015005366	D-loop; other site
240015005367	H-loop/switch region; other site
240015005368	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
240015005369	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
240015005370	PEGA domain; Region: PEGA; pfam08308
240015005371	EamA-like transporter family; Region: EamA; pfam00892
240015005372	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
240015005373	EamA-like transporter family; Region: EamA; pfam00892
240015005374	pantoate--beta-alanine ligase; Region: panC; TIGR00018
240015005375	Pantoate-beta-alanine ligase; Region: PanC; cd00560
240015005376	active site
240015005377	ATP-binding site [chemical binding]; other site
240015005378	pantoate-binding site; other site
240015005379	HXXH motif; other site
240015005380	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
240015005381	oligomerization interface [polypeptide binding]; other site
240015005382	active site
240015005383	metal binding site [ion binding]; metal-binding site
240015005384	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
240015005385	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
240015005386	ligand binding site; other site
240015005387	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015005388	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
240015005389	FtsX-like permease family; Region: FtsX; pfam02687
240015005390	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015005391	FtsX-like permease family; Region: FtsX; pfam02687
240015005392	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
240015005393	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240015005394	active site
240015005395	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
240015005396	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
240015005397	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
240015005398	dihydroorotase; Validated; Region: pyrC; PRK09357
240015005399	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
240015005400	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
240015005401	active site
240015005402	ribonuclease R; Region: RNase_R; TIGR02063
240015005403	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
240015005404	RNB domain; Region: RNB; pfam00773
240015005405	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
240015005406	RNA binding site [nucleotide binding]; other site
240015005407	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
240015005408	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
240015005409	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
240015005410	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
240015005411	active site
240015005412	FMN binding site [chemical binding]; other site
240015005413	substrate binding site [chemical binding]; other site
240015005414	homotetramer interface [polypeptide binding]; other site
240015005415	catalytic residue [active]
240015005416	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
240015005417	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
240015005418	DNA binding residues [nucleotide binding]
240015005419	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
240015005420	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
240015005421	minor groove reading motif; other site
240015005422	helix-hairpin-helix signature motif; other site
240015005423	substrate binding pocket [chemical binding]; other site
240015005424	active site
240015005425	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
240015005426	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
240015005427	nudix motif; other site
240015005428	adenosine deaminase; Provisional; Region: PRK09358
240015005429	active site
240015005430	aconitate hydratase; Validated; Region: PRK09277
240015005431	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
240015005432	substrate binding site [chemical binding]; other site
240015005433	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
240015005434	ligand binding site [chemical binding]; other site
240015005435	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
240015005436	substrate binding site [chemical binding]; other site
240015005437	putative folate metabolism protein, CADD family; Region: fol_rel_CADD; TIGR04305
240015005438	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
240015005439	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
240015005440	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
240015005441	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
240015005442	DinB family; Region: DinB; cl17821
240015005443	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
240015005444	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
240015005445	IHF - DNA interface [nucleotide binding]; other site
240015005446	IHF dimer interface [polypeptide binding]; other site
240015005447	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
240015005448	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
240015005449	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240015005450	ATP binding site [chemical binding]; other site
240015005451	putative Mg++ binding site [ion binding]; other site
240015005452	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240015005453	nucleotide binding region [chemical binding]; other site
240015005454	ATP-binding site [chemical binding]; other site
240015005455	DEAD/H associated; Region: DEAD_assoc; pfam08494
240015005456	FtsH Extracellular; Region: FtsH_ext; pfam06480
240015005457	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
240015005458	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015005459	Walker A motif; other site
240015005460	ATP binding site [chemical binding]; other site
240015005461	Walker B motif; other site
240015005462	Peptidase family M41; Region: Peptidase_M41; pfam01434
240015005463	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
240015005464	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
240015005465	dimerization interface [polypeptide binding]; other site
240015005466	active site
240015005467	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
240015005468	dsRNA binding site [nucleotide binding]; other site
240015005469	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
240015005470	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
240015005471	Catalytic site [active]
240015005472	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
240015005473	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
240015005474	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
240015005475	Catalytic site [active]
240015005476	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
240015005477	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
240015005478	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
240015005479	Zn binding site [ion binding]; other site
240015005480	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
240015005481	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
240015005482	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
240015005483	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015005484	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015005485	RNA polymerase sigma factor; Reviewed; Region: PRK05602
240015005486	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015005487	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015005488	DNA binding residues [nucleotide binding]
240015005489	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
240015005490	Double zinc ribbon; Region: DZR; pfam12773
240015005491	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
240015005492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015005493	active site
240015005494	phosphorylation site [posttranslational modification]
240015005495	intermolecular recognition site; other site
240015005496	dimerization interface [polypeptide binding]; other site
240015005497	LytTr DNA-binding domain; Region: LytTR; smart00850
240015005498	FecR protein; Region: FecR; pfam04773
240015005499	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
240015005500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
240015005501	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
240015005502	RuvA N terminal domain; Region: RuvA_N; pfam01330
240015005503	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
240015005504	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
240015005505	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
240015005506	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
240015005507	active site
240015005508	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
240015005509	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240015005510	active site
240015005511	Uncharacterized conserved protein [Function unknown]; Region: COG3543
240015005512	OPT oligopeptide transporter protein; Region: OPT; cl14607
240015005513	OPT oligopeptide transporter protein; Region: OPT; cl14607
240015005514	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
240015005515	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
240015005516	active site
240015005517	dimer interface [polypeptide binding]; other site
240015005518	non-prolyl cis peptide bond; other site
240015005519	insertion regions; other site
240015005520	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240015005521	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
240015005522	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
240015005523	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
240015005524	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
240015005525	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
240015005526	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
240015005527	putative active site [active]
240015005528	catalytic residue [active]
240015005529	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
240015005530	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
240015005531	5S rRNA interface [nucleotide binding]; other site
240015005532	CTC domain interface [polypeptide binding]; other site
240015005533	L16 interface [polypeptide binding]; other site
240015005534	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
240015005535	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
240015005536	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240015005537	active site
240015005538	4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947
240015005539	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
240015005540	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
240015005541	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
240015005542	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240015005543	inhibitor-cofactor binding pocket; inhibition site
240015005544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015005545	catalytic residue [active]
240015005546	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
240015005547	nucleotide binding site/active site [active]
240015005548	HIT family signature motif; other site
240015005549	catalytic residue [active]
240015005550	GTP-binding protein YchF; Reviewed; Region: PRK09601
240015005551	YchF GTPase; Region: YchF; cd01900
240015005552	G1 box; other site
240015005553	GTP/Mg2+ binding site [chemical binding]; other site
240015005554	Switch I region; other site
240015005555	G2 box; other site
240015005556	Switch II region; other site
240015005557	G3 box; other site
240015005558	G4 box; other site
240015005559	G5 box; other site
240015005560	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
240015005561	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
240015005562	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
240015005563	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240015005564	ATP binding site [chemical binding]; other site
240015005565	putative Mg++ binding site [ion binding]; other site
240015005566	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240015005567	nucleotide binding region [chemical binding]; other site
240015005568	ATP-binding site [chemical binding]; other site
240015005569	TRCF domain; Region: TRCF; pfam03461
240015005570	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
240015005571	active site
240015005572	tetramer interface; other site
240015005573	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
240015005574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015005575	Walker A motif; other site
240015005576	ATP binding site [chemical binding]; other site
240015005577	Walker B motif; other site
240015005578	arginine finger; other site
240015005579	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
240015005580	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
240015005581	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015005582	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240015005583	putative active site [active]
240015005584	heme pocket [chemical binding]; other site
240015005585	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240015005586	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015005587	putative active site [active]
240015005588	heme pocket [chemical binding]; other site
240015005589	Fic family protein [Function unknown]; Region: COG3177
240015005590	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
240015005591	Fic/DOC family; Region: Fic; pfam02661
240015005592	DNA gyrase subunit A; Validated; Region: PRK05560
240015005593	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
240015005594	CAP-like domain; other site
240015005595	active site
240015005596	primary dimer interface [polypeptide binding]; other site
240015005597	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240015005598	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240015005599	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240015005600	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
240015005601	Domain of unknown function (DUF336); Region: DUF336; pfam03928
240015005602	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
240015005603	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
240015005604	GrpE; Region: GrpE; pfam01025
240015005605	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
240015005606	dimer interface [polypeptide binding]; other site
240015005607	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
240015005608	chaperone protein DnaJ; Provisional; Region: PRK10767
240015005609	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240015005610	HSP70 interaction site [polypeptide binding]; other site
240015005611	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
240015005612	Zn binding sites [ion binding]; other site
240015005613	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
240015005614	dimer interface [polypeptide binding]; other site
240015005615	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
240015005616	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
240015005617	putative NAD(P) binding site [chemical binding]; other site
240015005618	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
240015005619	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
240015005620	Moco binding site; other site
240015005621	metal coordination site [ion binding]; other site
240015005622	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
240015005623	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
240015005624	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
240015005625	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
240015005626	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
240015005627	lipoyl attachment site [posttranslational modification]; other site
240015005628	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
240015005629	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
240015005630	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015005631	tetramer interface [polypeptide binding]; other site
240015005632	catalytic residue [active]
240015005633	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
240015005634	tetramer interface [polypeptide binding]; other site
240015005635	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015005636	catalytic residue [active]
240015005637	Protein of unknown function (DUF3419); Region: DUF3419; cl15422
240015005638	DoxX-like family; Region: DoxX_3; pfam13781
240015005639	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
240015005640	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
240015005641	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
240015005642	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
240015005643	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
240015005644	dimer interface [polypeptide binding]; other site
240015005645	putative radical transfer pathway; other site
240015005646	diiron center [ion binding]; other site
240015005647	tyrosyl radical; other site
240015005648	ribonucleoside--diphosphate reductase large subunit; Region: PLN02437
240015005649	ATP cone domain; Region: ATP-cone; pfam03477
240015005650	Class I ribonucleotide reductase; Region: RNR_I; cd01679
240015005651	active site
240015005652	dimer interface [polypeptide binding]; other site
240015005653	catalytic residues [active]
240015005654	effector binding site; other site
240015005655	R2 peptide binding site; other site
240015005656	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
240015005657	Two component regulator propeller; Region: Reg_prop; pfam07494
240015005658	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
240015005659	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
240015005660	Histidine kinase; Region: HisKA_3; pfam07730
240015005661	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015005662	ATP binding site [chemical binding]; other site
240015005663	Mg2+ binding site [ion binding]; other site
240015005664	G-X-G motif; other site
240015005665	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015005666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015005667	active site
240015005668	phosphorylation site [posttranslational modification]
240015005669	intermolecular recognition site; other site
240015005670	dimerization interface [polypeptide binding]; other site
240015005671	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015005672	DNA binding residues [nucleotide binding]
240015005673	dimerization interface [polypeptide binding]; other site
240015005674	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
240015005675	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
240015005676	membrane protein insertase; Provisional; Region: PRK01318
240015005677	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
240015005678	Haemolytic domain; Region: Haemolytic; pfam01809
240015005679	Ribonuclease P; Region: Ribonuclease_P; pfam00825
240015005680	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
240015005681	DnaA N-terminal domain; Region: DnaA_N; pfam11638
240015005682	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
240015005683	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015005684	Walker A motif; other site
240015005685	ATP binding site [chemical binding]; other site
240015005686	Walker B motif; other site
240015005687	arginine finger; other site
240015005688	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
240015005689	DnaA box-binding interface [nucleotide binding]; other site
240015005690	Acyltransferase family; Region: Acyl_transf_3; pfam01757
240015005691	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015005692	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015005693	FtsX-like permease family; Region: FtsX; pfam02687
240015005694	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015005695	transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433
240015005696	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015005697	RDD family; Region: RDD; pfam06271
240015005698	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
240015005699	Organic solvent tolerance protein; Region: OstA_C; pfam04453
240015005700	Thioredoxin; Region: Thioredoxin_4; pfam13462
240015005701	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
240015005702	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
240015005703	SurA N-terminal domain; Region: SurA_N_3; cl07813
240015005704	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
240015005705	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
240015005706	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240015005707	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
240015005708	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
240015005709	carboxyltransferase (CT) interaction site; other site
240015005710	biotinylation site [posttranslational modification]; other site
240015005711	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
240015005712	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
240015005713	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240015005714	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
240015005715	TPR repeat; Region: TPR_11; pfam13414
240015005716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015005717	binding surface
240015005718	TPR motif; other site
240015005719	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
240015005720	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
240015005721	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
240015005722	TolR protein; Region: tolR; TIGR02801
240015005723	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
240015005724	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
240015005725	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
240015005726	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
240015005727	Protein export membrane protein; Region: SecD_SecF; pfam02355
240015005728	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
240015005729	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
240015005730	Preprotein translocase subunit; Region: YajC; pfam02699
240015005731	Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601
240015005732	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
240015005733	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240015005734	catalytic residues [active]
240015005735	Uncharacterized conserved protein [Function unknown]; Region: COG3287
240015005736	FIST N domain; Region: FIST; pfam08495
240015005737	FIST C domain; Region: FIST_C; pfam10442
240015005738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
240015005739	PAS fold; Region: PAS_3; pfam08447
240015005740	putative active site [active]
240015005741	heme pocket [chemical binding]; other site
240015005742	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
240015005743	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015005744	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015005745	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015005746	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015005747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015005748	active site
240015005749	phosphorylation site [posttranslational modification]
240015005750	intermolecular recognition site; other site
240015005751	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
240015005752	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
240015005753	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015005754	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015005755	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015005756	GTPase CgtA; Reviewed; Region: obgE; PRK12299
240015005757	GTP1/OBG; Region: GTP1_OBG; pfam01018
240015005758	Obg GTPase; Region: Obg; cd01898
240015005759	G1 box; other site
240015005760	GTP/Mg2+ binding site [chemical binding]; other site
240015005761	Switch I region; other site
240015005762	G2 box; other site
240015005763	G3 box; other site
240015005764	Switch II region; other site
240015005765	G4 box; other site
240015005766	G5 box; other site
240015005767	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
240015005768	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
240015005769	active site
240015005770	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
240015005771	dimer interface [polypeptide binding]; other site
240015005772	substrate binding site [chemical binding]; other site
240015005773	catalytic residues [active]
240015005774	TspO/MBR family; Region: TspO_MBR; pfam03073
240015005775	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
240015005776	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
240015005777	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
240015005778	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
240015005779	active site
240015005780	dimer interface [polypeptide binding]; other site
240015005781	motif 1; other site
240015005782	motif 2; other site
240015005783	motif 3; other site
240015005784	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
240015005785	anticodon binding site; other site
240015005786	Divergent AAA domain; Region: AAA_4; pfam04326
240015005787	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
240015005788	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
240015005789	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240015005790	P-loop; other site
240015005791	Magnesium ion binding site [ion binding]; other site
240015005792	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240015005793	Magnesium ion binding site [ion binding]; other site
240015005794	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
240015005795	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
240015005796	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
240015005797	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240015005798	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240015005799	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240015005800	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
240015005801	putative acyl-acceptor binding pocket; other site
240015005802	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
240015005803	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
240015005804	catalytic triad [active]
240015005805	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
240015005806	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
240015005807	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
240015005808	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240015005809	P-loop; other site
240015005810	Magnesium ion binding site [ion binding]; other site
240015005811	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
240015005812	Magnesium ion binding site [ion binding]; other site
240015005813	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
240015005814	ParB-like nuclease domain; Region: ParBc; pfam02195
240015005815	KorB domain; Region: KorB; pfam08535
240015005816	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240015005817	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
240015005818	putative ADP-binding pocket [chemical binding]; other site
240015005819	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
240015005820	Protein of unknown function DUF72; Region: DUF72; pfam01904
240015005821	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
240015005822	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
240015005823	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
240015005824	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
240015005825	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015005826	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
240015005827	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
240015005828	trmE is a tRNA modification GTPase; Region: trmE; cd04164
240015005829	G1 box; other site
240015005830	GTP/Mg2+ binding site [chemical binding]; other site
240015005831	Switch I region; other site
240015005832	G2 box; other site
240015005833	Switch II region; other site
240015005834	G3 box; other site
240015005835	G4 box; other site
240015005836	G5 box; other site
240015005837	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
240015005838	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
240015005839	G-X-X-G motif; other site
240015005840	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
240015005841	RxxxH motif; other site
240015005842	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
240015005843	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
240015005844	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
240015005845	dimer interface [polypeptide binding]; other site
240015005846	active site
240015005847	Schiff base residues; other site
240015005848	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
240015005849	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
240015005850	YceG-like family; Region: YceG; pfam02618
240015005851	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
240015005852	dimerization interface [polypeptide binding]; other site
240015005853	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
240015005854	Predicted membrane protein [Function unknown]; Region: COG1289
240015005855	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
240015005856	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
240015005857	DNA polymerase III subunit beta; Validated; Region: PRK05643
240015005858	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
240015005859	putative DNA binding surface [nucleotide binding]; other site
240015005860	dimer interface [polypeptide binding]; other site
240015005861	beta-clamp/clamp loader binding surface; other site
240015005862	beta-clamp/translesion DNA polymerase binding surface; other site
240015005863	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
240015005864	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015005865	active site
240015005866	phosphorylation site [posttranslational modification]
240015005867	intermolecular recognition site; other site
240015005868	dimerization interface [polypeptide binding]; other site
240015005869	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
240015005870	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240015005871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015005872	ATP binding site [chemical binding]; other site
240015005873	Mg2+ binding site [ion binding]; other site
240015005874	G-X-G motif; other site
240015005875	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
240015005876	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
240015005877	Transcriptional regulator [Transcription]; Region: LysR; COG0583
240015005878	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240015005879	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
240015005880	putative dimerization interface [polypeptide binding]; other site
240015005881	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
240015005882	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
240015005883	DNA interaction; other site
240015005884	Metal-binding active site; metal-binding site
240015005885	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
240015005886	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
240015005887	Dimer interface [polypeptide binding]; other site
240015005888	anticodon binding site; other site
240015005889	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
240015005890	homodimer interface [polypeptide binding]; other site
240015005891	motif 1; other site
240015005892	motif 2; other site
240015005893	active site
240015005894	motif 3; other site
240015005895	agmatinase; Region: agmatinase; TIGR01230
240015005896	Arginase family; Region: Arginase; cd09989
240015005897	active site
240015005898	Mn binding site [ion binding]; other site
240015005899	oligomer interface [polypeptide binding]; other site
240015005900	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
240015005901	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015005902	non-specific DNA binding site [nucleotide binding]; other site
240015005903	salt bridge; other site
240015005904	sequence-specific DNA binding site [nucleotide binding]; other site
240015005905	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
240015005906	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
240015005907	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
240015005908	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
240015005909	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
240015005910	catalytic motif [active]
240015005911	Catalytic residue [active]
240015005912	Aspartyl protease; Region: Asp_protease_2; pfam13650
240015005913	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240015005914	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015005915	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
240015005916	elongation factor G; Reviewed; Region: PRK12740
240015005917	G1 box; other site
240015005918	putative GEF interaction site [polypeptide binding]; other site
240015005919	GTP/Mg2+ binding site [chemical binding]; other site
240015005920	Switch I region; other site
240015005921	G2 box; other site
240015005922	G3 box; other site
240015005923	Switch II region; other site
240015005924	G4 box; other site
240015005925	G5 box; other site
240015005926	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
240015005927	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
240015005928	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
240015005929	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
240015005930	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240015005931	inhibitor-cofactor binding pocket; inhibition site
240015005932	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015005933	catalytic residue [active]
240015005934	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
240015005935	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
240015005936	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
240015005937	EamA-like transporter family; Region: EamA; pfam00892
240015005938	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
240015005939	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
240015005940	active site
240015005941	HIGH motif; other site
240015005942	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
240015005943	KMSKS motif; other site
240015005944	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
240015005945	tRNA binding surface [nucleotide binding]; other site
240015005946	anticodon binding site; other site
240015005947	UGMP family protein; Validated; Region: PRK09604
240015005948	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
240015005949	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
240015005950	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
240015005951	active site
240015005952	NTP binding site [chemical binding]; other site
240015005953	metal binding triad [ion binding]; metal-binding site
240015005954	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
240015005955	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
240015005956	Zn2+ binding site [ion binding]; other site
240015005957	Mg2+ binding site [ion binding]; other site
240015005958	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
240015005959	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
240015005960	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
240015005961	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
240015005962	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
240015005963	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
240015005964	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015005965	NAD(P) binding site [chemical binding]; other site
240015005966	active site
240015005967	bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520
240015005968	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
240015005969	active site
240015005970	catalytic residue [active]
240015005971	dimer interface [polypeptide binding]; other site
240015005972	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
240015005973	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
240015005974	NAD(P) binding site [chemical binding]; other site
240015005975	shikimate binding site; other site
240015005976	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
240015005977	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
240015005978	active site
240015005979	Zn binding site [ion binding]; other site
240015005980	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
240015005981	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240015005982	Coenzyme A binding pocket [chemical binding]; other site
240015005983	Acetokinase family; Region: Acetate_kinase; cl17229
240015005984	propionate/acetate kinase; Provisional; Region: PRK12379
240015005985	putative phosphoketolase; Provisional; Region: PRK05261
240015005986	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
240015005987	TPP-binding site; other site
240015005988	XFP C-terminal domain; Region: XFP_C; pfam09363
240015005989	Family description; Region: VCBS; pfam13517
240015005990	Family description; Region: VCBS; pfam13517
240015005991	Family description; Region: VCBS; pfam13517
240015005992	Family description; Region: VCBS; pfam13517
240015005993	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
240015005994	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015005995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015005996	binding surface
240015005997	TPR motif; other site
240015005998	TPR repeat; Region: TPR_11; pfam13414
240015005999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015006000	binding surface
240015006001	TPR motif; other site
240015006002	TPR repeat; Region: TPR_11; pfam13414
240015006003	TPR repeat; Region: TPR_11; pfam13414
240015006004	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015006005	TPR motif; other site
240015006006	binding surface
240015006007	Uncharacterized conserved protein [Function unknown]; Region: COG3391
240015006008	SdiA-regulated; Region: SdiA-regulated; cd09971
240015006009	Methyltransferase domain; Region: Methyltransf_31; pfam13847
240015006010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015006011	S-adenosylmethionine binding site [chemical binding]; other site
240015006012	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
240015006013	anti sigma factor interaction site; other site
240015006014	regulatory phosphorylation site [posttranslational modification]; other site
240015006015	Protein of unknown function (DUF422); Region: DUF422; pfam04240
240015006016	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
240015006017	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
240015006018	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
240015006019	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
240015006020	23S rRNA binding site [nucleotide binding]; other site
240015006021	L21 binding site [polypeptide binding]; other site
240015006022	L13 binding site [polypeptide binding]; other site
240015006023	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
240015006024	dihydropteroate synthase; Region: DHPS; TIGR01496
240015006025	substrate binding pocket [chemical binding]; other site
240015006026	dimer interface [polypeptide binding]; other site
240015006027	inhibitor binding site; inhibition site
240015006028	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
240015006029	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
240015006030	Cytochrome c; Region: Cytochrom_C; pfam00034
240015006031	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
240015006032	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
240015006033	Substrate-binding site [chemical binding]; other site
240015006034	Substrate specificity [chemical binding]; other site
240015006035	translation initiation factor IF-3; Region: infC; TIGR00168
240015006036	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
240015006037	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
240015006038	Response regulator receiver domain; Region: Response_reg; pfam00072
240015006039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015006040	active site
240015006041	phosphorylation site [posttranslational modification]
240015006042	intermolecular recognition site; other site
240015006043	dimerization interface [polypeptide binding]; other site
240015006044	Probable zinc-binding domain; Region: zf-trcl; pfam13451
240015006045	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
240015006046	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
240015006047	SnoaL-like domain; Region: SnoaL_3; pfam13474
240015006048	SnoaL-like domain; Region: SnoaL_2; pfam12680
240015006049	Uncharacterized conserved protein [Function unknown]; Region: COG1359
240015006050	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
240015006051	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
240015006052	GDP-binding site [chemical binding]; other site
240015006053	ACT binding site; other site
240015006054	IMP binding site; other site
240015006055	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14810
240015006056	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
240015006057	DNA binding site [nucleotide binding]
240015006058	catalytic residue [active]
240015006059	H2TH interface [polypeptide binding]; other site
240015006060	putative catalytic residues [active]
240015006061	turnover-facilitating residue; other site
240015006062	intercalation triad [nucleotide binding]; other site
240015006063	8OG recognition residue [nucleotide binding]; other site
240015006064	putative reading head residues; other site
240015006065	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
240015006066	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
240015006067	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
240015006068	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
240015006069	transmembrane helices; other site
240015006070	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
240015006071	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
240015006072	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
240015006073	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
240015006074	homodimer interface [polypeptide binding]; other site
240015006075	Walker A motif; other site
240015006076	ATP binding site [chemical binding]; other site
240015006077	hydroxycobalamin binding site [chemical binding]; other site
240015006078	Walker B motif; other site
240015006079	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
240015006080	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015006081	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
240015006082	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
240015006083	MutS domain III; Region: MutS_III; pfam05192
240015006084	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015006085	Walker A/P-loop; other site
240015006086	ATP binding site [chemical binding]; other site
240015006087	Q-loop/lid; other site
240015006088	ABC transporter signature motif; other site
240015006089	Walker B; other site
240015006090	D-loop; other site
240015006091	H-loop/switch region; other site
240015006092	Smr domain; Region: Smr; pfam01713
240015006093	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
240015006094	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
240015006095	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
240015006096	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
240015006097	Domain interface; other site
240015006098	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
240015006099	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
240015006100	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
240015006101	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
240015006102	TPP-binding site [chemical binding]; other site
240015006103	dimer interface [polypeptide binding]; other site
240015006104	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
240015006105	PYR/PP interface [polypeptide binding]; other site
240015006106	dimer interface [polypeptide binding]; other site
240015006107	TPP binding site [chemical binding]; other site
240015006108	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
240015006109	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
240015006110	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
240015006111	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015006112	motif II; other site
240015006113	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
240015006114	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
240015006115	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
240015006116	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
240015006117	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
240015006118	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
240015006119	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
240015006120	putative active site [active]
240015006121	glucokinase, proteobacterial type; Region: glk; TIGR00749
240015006122	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
240015006123	nucleotide binding site [chemical binding]; other site
240015006124	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
240015006125	Peptidase family M1; Region: Peptidase_M1; pfam01433
240015006126	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
240015006127	Zn binding site [ion binding]; other site
240015006128	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
240015006129	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
240015006130	active site
240015006131	DNA binding site [nucleotide binding]
240015006132	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
240015006133	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
240015006134	catalytic triad [active]
240015006135	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
240015006136	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015006137	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015006138	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
240015006139	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
240015006140	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
240015006141	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
240015006142	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
240015006143	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
240015006144	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
240015006145	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
240015006146	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240015006147	catalytic residue [active]
240015006148	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
240015006149	DNA-binding site [nucleotide binding]; DNA binding site
240015006150	RNA-binding motif; other site
240015006151	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
240015006152	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
240015006153	active site
240015006154	Zn binding site [ion binding]; other site
240015006155	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
240015006156	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240015006157	active site
240015006158	metal binding site [ion binding]; metal-binding site
240015006159	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
240015006160	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240015006161	active site
240015006162	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240015006163	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
240015006164	putative acyl-acceptor binding pocket; other site
240015006165	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
240015006166	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240015006167	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
240015006168	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
240015006169	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
240015006170	NAD(P) binding site [chemical binding]; other site
240015006171	catalytic residues [active]
240015006172	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240015006173	phytoene desaturase; Region: crtI_fam; TIGR02734
240015006174	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
240015006175	Na binding site [ion binding]; other site
240015006176	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
240015006177	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
240015006178	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
240015006179	catalytic residue [active]
240015006180	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
240015006181	CAAX protease self-immunity; Region: Abi; pfam02517
240015006182	putative acyltransferase; Provisional; Region: PRK05790
240015006183	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
240015006184	dimer interface [polypeptide binding]; other site
240015006185	active site
240015006186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015006187	S-adenosylmethionine binding site [chemical binding]; other site
240015006188	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
240015006189	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
240015006190	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
240015006191	ribosome recycling factor; Reviewed; Region: frr; PRK00083
240015006192	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
240015006193	hinge region; other site
240015006194	NAD-dependent deacetylase; Provisional; Region: PRK00481
240015006195	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
240015006196	NAD+ binding site [chemical binding]; other site
240015006197	substrate binding site [chemical binding]; other site
240015006198	Zn binding site [ion binding]; other site
240015006199	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
240015006200	catalytic center binding site [active]
240015006201	ATP binding site [chemical binding]; other site
240015006202	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
240015006203	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
240015006204	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
240015006205	RNA binding site [nucleotide binding]; other site
240015006206	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
240015006207	RNA binding site [nucleotide binding]; other site
240015006208	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
240015006209	RNA binding site [nucleotide binding]; other site
240015006210	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
240015006211	RNA binding site [nucleotide binding]; other site
240015006212	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
240015006213	RNA binding site [nucleotide binding]; other site
240015006214	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
240015006215	RNA binding site [nucleotide binding]; other site
240015006216	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
240015006217	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240015006218	catalytic loop [active]
240015006219	iron binding site [ion binding]; other site
240015006220	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
240015006221	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
240015006222	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
240015006223	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
240015006224	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
240015006225	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
240015006226	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
240015006227	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
240015006228	XdhC Rossmann domain; Region: XdhC_C; pfam13478
240015006229	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
240015006230	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
240015006231	metal-binding site
240015006232	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
240015006233	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
240015006234	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
240015006235	putative RNA binding site [nucleotide binding]; other site
240015006236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015006237	S-adenosylmethionine binding site [chemical binding]; other site
240015006238	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
240015006239	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
240015006240	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
240015006241	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
240015006242	active site
240015006243	HIGH motif; other site
240015006244	dimer interface [polypeptide binding]; other site
240015006245	KMSKS motif; other site
240015006246	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
240015006247	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
240015006248	homopentamer interface [polypeptide binding]; other site
240015006249	active site
240015006250	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
240015006251	putative RNA binding site [nucleotide binding]; other site
240015006252	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
240015006253	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
240015006254	substrate binding site [chemical binding]; other site
240015006255	oxyanion hole (OAH) forming residues; other site
240015006256	trimer interface [polypeptide binding]; other site
240015006257	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
240015006258	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
240015006259	FAD binding domain; Region: FAD_binding_4; pfam01565
240015006260	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
240015006261	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166
240015006262	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
240015006263	putative ligand binding site [chemical binding]; other site
240015006264	putative NAD binding site [chemical binding]; other site
240015006265	catalytic site [active]
240015006266	aspartate aminotransferase; Provisional; Region: PRK05764
240015006267	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240015006268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015006269	homodimer interface [polypeptide binding]; other site
240015006270	catalytic residue [active]
240015006271	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
240015006272	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
240015006273	catalytic residues [active]
240015006274	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
240015006275	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
240015006276	substrate binding site [chemical binding]; other site
240015006277	glutamase interaction surface [polypeptide binding]; other site
240015006278	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
240015006279	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
240015006280	putative active site [active]
240015006281	oxyanion strand; other site
240015006282	catalytic triad [active]
240015006283	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
240015006284	putative active site pocket [active]
240015006285	4-fold oligomerization interface [polypeptide binding]; other site
240015006286	metal binding residues [ion binding]; metal-binding site
240015006287	3-fold/trimer interface [polypeptide binding]; other site
240015006288	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
240015006289	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240015006290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015006291	homodimer interface [polypeptide binding]; other site
240015006292	catalytic residue [active]
240015006293	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
240015006294	histidinol dehydrogenase; Region: hisD; TIGR00069
240015006295	NAD binding site [chemical binding]; other site
240015006296	dimerization interface [polypeptide binding]; other site
240015006297	product binding site; other site
240015006298	substrate binding site [chemical binding]; other site
240015006299	zinc binding site [ion binding]; other site
240015006300	catalytic residues [active]
240015006301	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
240015006302	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
240015006303	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
240015006304	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
240015006305	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240015006306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015006307	ATP binding site [chemical binding]; other site
240015006308	Mg2+ binding site [ion binding]; other site
240015006309	G-X-G motif; other site
240015006310	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
240015006311	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
240015006312	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
240015006313	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
240015006314	dimer interface [polypeptide binding]; other site
240015006315	anticodon binding site; other site
240015006316	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
240015006317	homodimer interface [polypeptide binding]; other site
240015006318	motif 1; other site
240015006319	active site
240015006320	motif 2; other site
240015006321	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
240015006322	active site
240015006323	motif 3; other site
240015006324	Transposase IS200 like; Region: Y1_Tnp; pfam01797
240015006325	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
240015006326	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
240015006327	dimer interface [polypeptide binding]; other site
240015006328	motif 1; other site
240015006329	active site
240015006330	motif 2; other site
240015006331	motif 3; other site
240015006332	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
240015006333	anticodon binding site; other site
240015006334	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
240015006335	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
240015006336	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
240015006337	helicase 45; Provisional; Region: PTZ00424
240015006338	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
240015006339	ATP binding site [chemical binding]; other site
240015006340	Mg++ binding site [ion binding]; other site
240015006341	motif III; other site
240015006342	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240015006343	nucleotide binding region [chemical binding]; other site
240015006344	ATP-binding site [chemical binding]; other site
240015006345	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
240015006346	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
240015006347	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
240015006348	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
240015006349	E3 interaction surface; other site
240015006350	lipoyl attachment site [posttranslational modification]; other site
240015006351	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
240015006352	E3 interaction surface; other site
240015006353	lipoyl attachment site [posttranslational modification]; other site
240015006354	e3 binding domain; Region: E3_binding; pfam02817
240015006355	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
240015006356	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
240015006357	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
240015006358	NAD binding site [chemical binding]; other site
240015006359	ATP-grasp domain; Region: ATP-grasp; pfam02222
240015006360	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
240015006361	Phage-related protein [Function unknown]; Region: COG4695; cl01923
240015006362	Phage portal protein; Region: Phage_portal; pfam04860
240015006363	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
240015006364	HipA-like N-terminal domain; Region: HipA_N; pfam07805
240015006365	large terminase protein; Provisional; Region: 17; PHA02533
240015006366	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240015006367	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240015006368	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
240015006369	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
240015006370	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
240015006371	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
240015006372	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240015006373	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240015006374	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
240015006375	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
240015006376	thiamine phosphate binding site [chemical binding]; other site
240015006377	active site
240015006378	pyrophosphate binding site [ion binding]; other site
240015006379	SnoaL-like domain; Region: SnoaL_3; pfam13474
240015006380	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
240015006381	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015006382	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
240015006383	FeS/SAM binding site; other site
240015006384	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240015006385	protein binding site [polypeptide binding]; other site
240015006386	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
240015006387	protein binding site [polypeptide binding]; other site
240015006388	HEAT repeats; Region: HEAT_2; pfam13646
240015006389	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
240015006390	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015006391	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015006392	DNA binding residues [nucleotide binding]
240015006393	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
240015006394	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
240015006395	active site
240015006396	metal binding site [ion binding]; metal-binding site
240015006397	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
240015006398	RNA/DNA hybrid binding site [nucleotide binding]; other site
240015006399	active site
240015006400	Yqey-like protein; Region: YqeY; pfam09424
240015006401	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
240015006402	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240015006403	catalytic residue [active]
240015006404	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
240015006405	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
240015006406	ligand binding site [chemical binding]; other site
240015006407	NAD binding site [chemical binding]; other site
240015006408	dimerization interface [polypeptide binding]; other site
240015006409	catalytic site [active]
240015006410	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
240015006411	putative L-serine binding site [chemical binding]; other site
240015006412	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
240015006413	Bacitracin resistance protein BacA; Region: BacA; pfam02673
240015006414	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
240015006415	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
240015006416	FAD binding site [chemical binding]; other site
240015006417	homotetramer interface [polypeptide binding]; other site
240015006418	substrate binding pocket [chemical binding]; other site
240015006419	catalytic base [active]
240015006420	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
240015006421	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
240015006422	Walker A/P-loop; other site
240015006423	ATP binding site [chemical binding]; other site
240015006424	Q-loop/lid; other site
240015006425	ABC transporter signature motif; other site
240015006426	Walker B; other site
240015006427	D-loop; other site
240015006428	H-loop/switch region; other site
240015006429	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
240015006430	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
240015006431	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240015006432	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015006433	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015006434	DNA binding residues [nucleotide binding]
240015006435	Cytochrome c [Energy production and conversion]; Region: COG3258
240015006436	Cytochrome c; Region: Cytochrom_C; pfam00034
240015006437	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
240015006438	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
240015006439	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
240015006440	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
240015006441	putative dimer interface [polypeptide binding]; other site
240015006442	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
240015006443	Clp amino terminal domain; Region: Clp_N; pfam02861
240015006444	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015006445	Walker A motif; other site
240015006446	ATP binding site [chemical binding]; other site
240015006447	Walker B motif; other site
240015006448	arginine finger; other site
240015006449	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015006450	Walker A motif; other site
240015006451	ATP binding site [chemical binding]; other site
240015006452	Walker B motif; other site
240015006453	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
240015006454	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015006455	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015006456	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015006457	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
240015006458	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
240015006459	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
240015006460	trimer interface [polypeptide binding]; other site
240015006461	active site
240015006462	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
240015006463	catalytic site [active]
240015006464	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
240015006465	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
240015006466	Cl- selectivity filter; other site
240015006467	Cl- binding residues [ion binding]; other site
240015006468	pore gating glutamate residue; other site
240015006469	dimer interface [polypeptide binding]; other site
240015006470	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
240015006471	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
240015006472	PA14 domain; Region: PA14; cl08459
240015006473	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
240015006474	voltage-gated potassium channel; Provisional; Region: PRK10537
240015006475	Ion channel; Region: Ion_trans_2; pfam07885
240015006476	TrkA-N domain; Region: TrkA_N; pfam02254
240015006477	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
240015006478	PA14 domain; Region: PA14; pfam07691
240015006479	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
240015006480	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
240015006481	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
240015006482	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
240015006483	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
240015006484	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015006485	NAD(P) binding site [chemical binding]; other site
240015006486	active site
240015006487	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
240015006488	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
240015006489	putative [4Fe-4S] binding site [ion binding]; other site
240015006490	putative molybdopterin cofactor binding site [chemical binding]; other site
240015006491	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
240015006492	molybdopterin cofactor binding site; other site
240015006493	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
240015006494	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
240015006495	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
240015006496	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
240015006497	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
240015006498	Surface antigen; Region: Bac_surface_Ag; pfam01103
240015006499	periplasmic chaperone; Provisional; Region: PRK10780
240015006500	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
240015006501	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
240015006502	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
240015006503	methionine sulfoxide reductase A; Provisional; Region: PRK14054
240015006504	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
240015006505	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
240015006506	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
240015006507	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
240015006508	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
240015006509	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
240015006510	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015006511	active site
240015006512	motif I; other site
240015006513	motif II; other site
240015006514	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
240015006515	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
240015006516	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015006517	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
240015006518	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
240015006519	substrate binding site [chemical binding]; other site
240015006520	active site
240015006521	Ferrochelatase; Region: Ferrochelatase; pfam00762
240015006522	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
240015006523	C-terminal domain interface [polypeptide binding]; other site
240015006524	active site
240015006525	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
240015006526	active site
240015006527	N-terminal domain interface [polypeptide binding]; other site
240015006528	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
240015006529	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
240015006530	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
240015006531	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
240015006532	Cytochrome c; Region: Cytochrom_C; pfam00034
240015006533	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
240015006534	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
240015006535	D-pathway; other site
240015006536	Putative ubiquinol binding site [chemical binding]; other site
240015006537	Low-spin heme (heme b) binding site [chemical binding]; other site
240015006538	Putative water exit pathway; other site
240015006539	Binuclear center (heme o3/CuB) [ion binding]; other site
240015006540	K-pathway; other site
240015006541	Putative proton exit pathway; other site
240015006542	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
240015006543	Subunit I/III interface [polypeptide binding]; other site
240015006544	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
240015006545	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
240015006546	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
240015006547	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
240015006548	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
240015006549	iron-sulfur cluster [ion binding]; other site
240015006550	[2Fe-2S] cluster binding site [ion binding]; other site
240015006551	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
240015006552	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
240015006553	interchain domain interface [polypeptide binding]; other site
240015006554	intrachain domain interface; other site
240015006555	heme bH binding site [chemical binding]; other site
240015006556	Qi binding site; other site
240015006557	heme bL binding site [chemical binding]; other site
240015006558	Qo binding site; other site
240015006559	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
240015006560	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
240015006561	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
240015006562	Domain of unknown function DUF20; Region: UPF0118; pfam01594
240015006563	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
240015006564	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
240015006565	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
240015006566	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
240015006567	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015006568	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
240015006569	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015006570	DNA binding residues [nucleotide binding]
240015006571	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
240015006572	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
240015006573	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
240015006574	active site
240015006575	catalytic triad [active]
240015006576	oxyanion hole [active]
240015006577	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
240015006578	active site
240015006579	catalytic triad [active]
240015006580	oxyanion hole [active]
240015006581	CTP synthetase; Validated; Region: pyrG; PRK05380
240015006582	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
240015006583	Catalytic site [active]
240015006584	active site
240015006585	UTP binding site [chemical binding]; other site
240015006586	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
240015006587	active site
240015006588	putative oxyanion hole; other site
240015006589	catalytic triad [active]
240015006590	Homeodomain-like domain; Region: HTH_23; cl17451
240015006591	Integrase core domain; Region: rve; pfam00665
240015006592	Integrase core domain; Region: rve_3; pfam13683
240015006593	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
240015006594	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
240015006595	homotetramer interface [polypeptide binding]; other site
240015006596	ligand binding site [chemical binding]; other site
240015006597	catalytic site [active]
240015006598	NAD binding site [chemical binding]; other site
240015006599	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240015006600	dimerization interface [polypeptide binding]; other site
240015006601	putative DNA binding site [nucleotide binding]; other site
240015006602	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
240015006603	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015006604	NAD(P) binding site [chemical binding]; other site
240015006605	active site
240015006606	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
240015006607	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
240015006608	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
240015006609	DNA binding site [nucleotide binding]
240015006610	active site
240015006611	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
240015006612	adenylosuccinate lyase; Provisional; Region: PRK07492
240015006613	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
240015006614	tetramer interface [polypeptide binding]; other site
240015006615	active site
240015006616	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
240015006617	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
240015006618	Flavoprotein; Region: Flavoprotein; pfam02441
240015006619	CAAX protease self-immunity; Region: Abi; pfam02517
240015006620	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
240015006621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015006622	NAD(P) binding site [chemical binding]; other site
240015006623	active site
240015006624	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240015006625	active site
240015006626	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240015006627	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240015006628	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015006629	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015006630	metal binding site [ion binding]; metal-binding site
240015006631	active site
240015006632	I-site; other site
240015006633	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
240015006634	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
240015006635	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240015006636	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240015006637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015006638	S-adenosylmethionine binding site [chemical binding]; other site
240015006639	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
240015006640	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
240015006641	homodimer interface [polypeptide binding]; other site
240015006642	substrate-cofactor binding pocket; other site
240015006643	catalytic residue [active]
240015006644	MarC family integral membrane protein; Region: MarC; pfam01914
240015006645	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
240015006646	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
240015006647	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
240015006648	FMN binding site [chemical binding]; other site
240015006649	substrate binding site [chemical binding]; other site
240015006650	putative catalytic residue [active]
240015006651	Domain of unknown function DUF302; Region: DUF302; cl01364
240015006652	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
240015006653	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
240015006654	PIN domain; Region: PIN_3; cl17397
240015006655	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
240015006656	transcription termination factor Rho; Provisional; Region: rho; PRK09376
240015006657	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
240015006658	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
240015006659	RNA binding site [nucleotide binding]; other site
240015006660	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
240015006661	multimer interface [polypeptide binding]; other site
240015006662	Walker A motif; other site
240015006663	ATP binding site [chemical binding]; other site
240015006664	Walker B motif; other site
240015006665	Predicted transcriptional regulators [Transcription]; Region: COG1725
240015006666	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
240015006667	DNA-binding site [nucleotide binding]; DNA binding site
240015006668	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
240015006669	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
240015006670	Walker A/P-loop; other site
240015006671	ATP binding site [chemical binding]; other site
240015006672	Q-loop/lid; other site
240015006673	ABC transporter signature motif; other site
240015006674	Walker B; other site
240015006675	D-loop; other site
240015006676	H-loop/switch region; other site
240015006677	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
240015006678	peptidase domain interface [polypeptide binding]; other site
240015006679	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
240015006680	active site
240015006681	catalytic triad [active]
240015006682	calcium binding site [ion binding]; other site
240015006683	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015006684	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015006685	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240015006686	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240015006687	Walker A/P-loop; other site
240015006688	ATP binding site [chemical binding]; other site
240015006689	Q-loop/lid; other site
240015006690	ABC transporter signature motif; other site
240015006691	Walker B; other site
240015006692	D-loop; other site
240015006693	H-loop/switch region; other site
240015006694	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015006695	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015006696	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015006697	FtsX-like permease family; Region: FtsX; pfam02687
240015006698	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240015006699	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240015006700	Walker A/P-loop; other site
240015006701	ATP binding site [chemical binding]; other site
240015006702	Q-loop/lid; other site
240015006703	ABC transporter signature motif; other site
240015006704	Walker B; other site
240015006705	D-loop; other site
240015006706	H-loop/switch region; other site
240015006707	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
240015006708	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
240015006709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015006710	active site
240015006711	phosphorylation site [posttranslational modification]
240015006712	intermolecular recognition site; other site
240015006713	dimerization interface [polypeptide binding]; other site
240015006714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015006715	Walker A motif; other site
240015006716	ATP binding site [chemical binding]; other site
240015006717	Walker B motif; other site
240015006718	arginine finger; other site
240015006719	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
240015006720	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
240015006721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015006722	ATP binding site [chemical binding]; other site
240015006723	Mg2+ binding site [ion binding]; other site
240015006724	G-X-G motif; other site
240015006725	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015006726	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015006727	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015006728	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015006729	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015006730	FtsX-like permease family; Region: FtsX; pfam02687
240015006731	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015006732	FtsX-like permease family; Region: FtsX; pfam02687
240015006733	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015006734	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015006735	FtsX-like permease family; Region: FtsX; pfam02687
240015006736	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015006737	FtsX-like permease family; Region: FtsX; pfam02687
240015006738	Trehalase; Region: Trehalase; cl17346
240015006739	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
240015006740	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
240015006741	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
240015006742	Ca binding site [ion binding]; other site
240015006743	active site
240015006744	catalytic site [active]
240015006745	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
240015006746	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
240015006747	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
240015006748	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
240015006749	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015006750	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015006751	Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087
240015006752	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340
240015006753	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
240015006754	Ca binding site [ion binding]; other site
240015006755	active site
240015006756	homodimer interface [polypeptide binding]; other site
240015006757	catalytic site [active]
240015006758	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240015006759	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240015006760	active site
240015006761	catalytic tetrad [active]
240015006762	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
240015006763	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
240015006764	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
240015006765	4Fe-4S binding domain; Region: Fer4; cl02805
240015006766	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015006767	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015006768	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015006769	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015006770	binding surface
240015006771	Tetratricopeptide repeat; Region: TPR_16; pfam13432
240015006772	TPR motif; other site
240015006773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015006774	TPR motif; other site
240015006775	binding surface
240015006776	TPR repeat; Region: TPR_11; pfam13414
240015006777	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015006778	binding surface
240015006779	TPR motif; other site
240015006780	TPR repeat; Region: TPR_11; pfam13414
240015006781	Domain of unknown function (DUF1793); Region: DUF1793; pfam08760
240015006782	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
240015006783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015006784	putative substrate translocation pore; other site
240015006785	D-galactonate transporter; Region: 2A0114; TIGR00893
240015006786	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015006787	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
240015006788	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015006789	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
240015006790	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240015006791	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240015006792	Walker A/P-loop; other site
240015006793	ATP binding site [chemical binding]; other site
240015006794	Q-loop/lid; other site
240015006795	ABC transporter signature motif; other site
240015006796	Walker B; other site
240015006797	D-loop; other site
240015006798	H-loop/switch region; other site
240015006799	DevC protein; Region: devC; TIGR01185
240015006800	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015006801	FtsX-like permease family; Region: FtsX; pfam02687
240015006802	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
240015006803	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
240015006804	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
240015006805	putative dimer interface [polypeptide binding]; other site
240015006806	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
240015006807	Ligand Binding Site [chemical binding]; other site
240015006808	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
240015006809	BON domain; Region: BON; pfam04972
240015006810	BON domain; Region: BON; pfam04972
240015006811	BON domain; Region: BON; pfam04972
240015006812	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
240015006813	BON domain; Region: BON; pfam04972
240015006814	BON domain; Region: BON; pfam04972
240015006815	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
240015006816	Predicted transcriptional regulator [Transcription]; Region: COG1959
240015006817	Transcriptional regulator; Region: Rrf2; pfam02082
240015006818	cysteine desulfurase; Provisional; Region: PRK14012
240015006819	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
240015006820	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240015006821	catalytic residue [active]
240015006822	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
240015006823	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
240015006824	trimerization site [polypeptide binding]; other site
240015006825	active site
240015006826	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
240015006827	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
240015006828	HSP70 interaction site [polypeptide binding]; other site
240015006829	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
240015006830	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
240015006831	chaperone protein HscA; Provisional; Region: hscA; PRK05183
240015006832	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
240015006833	nucleotide binding site [chemical binding]; other site
240015006834	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
240015006835	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
240015006836	catalytic loop [active]
240015006837	iron binding site [ion binding]; other site
240015006838	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
240015006839	PBP superfamily domain; Region: PBP_like_2; cl17296
240015006840	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
240015006841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240015006842	dimer interface [polypeptide binding]; other site
240015006843	conserved gate region; other site
240015006844	putative PBP binding loops; other site
240015006845	ABC-ATPase subunit interface; other site
240015006846	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
240015006847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
240015006848	dimer interface [polypeptide binding]; other site
240015006849	conserved gate region; other site
240015006850	putative PBP binding loops; other site
240015006851	ABC-ATPase subunit interface; other site
240015006852	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
240015006853	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
240015006854	dimer interface [polypeptide binding]; other site
240015006855	decamer (pentamer of dimers) interface [polypeptide binding]; other site
240015006856	catalytic triad [active]
240015006857	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
240015006858	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240015006859	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240015006860	Walker A/P-loop; other site
240015006861	ATP binding site [chemical binding]; other site
240015006862	Q-loop/lid; other site
240015006863	ABC transporter signature motif; other site
240015006864	Walker B; other site
240015006865	D-loop; other site
240015006866	H-loop/switch region; other site
240015006867	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
240015006868	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
240015006869	NADH dehydrogenase subunit B; Provisional; Region: PRK14819
240015006870	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
240015006871	NADH dehydrogenase subunit D; Validated; Region: PRK06075
240015006872	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
240015006873	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
240015006874	4Fe-4S binding domain; Region: Fer4; pfam00037
240015006875	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
240015006876	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
240015006877	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
240015006878	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
240015006879	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240015006880	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
240015006881	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
240015006882	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240015006883	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
240015006884	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240015006885	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
240015006886	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
240015006887	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
240015006888	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
240015006889	Competence protein; Region: Competence; pfam03772
240015006890	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
240015006891	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240015006892	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
240015006893	TRAM domain; Region: TRAM; cl01282
240015006894	Methyltransferase domain; Region: Methyltransf_18; pfam12847
240015006895	pantothenate kinase; Reviewed; Region: PRK13318
240015006896	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
240015006897	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
240015006898	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
240015006899	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
240015006900	dimerization interface [polypeptide binding]; other site
240015006901	active site
240015006902	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
240015006903	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
240015006904	HIGH motif; other site
240015006905	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
240015006906	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
240015006907	active site
240015006908	KMSKS motif; other site
240015006909	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
240015006910	tRNA binding surface [nucleotide binding]; other site
240015006911	anticodon binding site; other site
240015006912	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
240015006913	Tetratricopeptide repeat; Region: TPR_18; pfam13512
240015006914	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
240015006915	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
240015006916	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
240015006917	substrate binding site [chemical binding]; other site
240015006918	hexamer interface [polypeptide binding]; other site
240015006919	metal binding site [ion binding]; metal-binding site
240015006920	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
240015006921	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
240015006922	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240015006923	RNA binding surface [nucleotide binding]; other site
240015006924	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
240015006925	active site
240015006926	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
240015006927	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
240015006928	ScpA/B protein; Region: ScpA_ScpB; cl00598
240015006929	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
240015006930	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
240015006931	active site
240015006932	HIGH motif; other site
240015006933	dimer interface [polypeptide binding]; other site
240015006934	KMSKS motif; other site
240015006935	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
240015006936	Peptidase family M50; Region: Peptidase_M50; pfam02163
240015006937	active site
240015006938	putative substrate binding region [chemical binding]; other site
240015006939	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
240015006940	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
240015006941	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
240015006942	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
240015006943	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
240015006944	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
240015006945	peptidase domain interface [polypeptide binding]; other site
240015006946	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
240015006947	active site
240015006948	catalytic triad [active]
240015006949	calcium binding site [ion binding]; other site
240015006950	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
240015006951	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
240015006952	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
240015006953	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
240015006954	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
240015006955	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
240015006956	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240015006957	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015006958	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015006959	DNA binding residues [nucleotide binding]
240015006960	transposase/IS protein; Provisional; Region: PRK09183
240015006961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015006962	Walker A motif; other site
240015006963	ATP binding site [chemical binding]; other site
240015006964	Walker B motif; other site
240015006965	arginine finger; other site
240015006966	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
240015006967	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
240015006968	putative active site [active]
240015006969	putative NTP binding site [chemical binding]; other site
240015006970	putative nucleic acid binding site [nucleotide binding]; other site
240015006971	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
240015006972	HTH-like domain; Region: HTH_21; pfam13276
240015006973	Integrase core domain; Region: rve; pfam00665
240015006974	Integrase core domain; Region: rve_3; pfam13683
240015006975	Transposase; Region: HTH_Tnp_1; pfam01527
240015006976	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
240015006977	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
240015006978	CoA-ligase; Region: Ligase_CoA; pfam00549
240015006979	four helix bundle protein; Region: TIGR02436
240015006980	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
240015006981	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
240015006982	CoA binding domain; Region: CoA_binding; smart00881
240015006983	CoA-ligase; Region: Ligase_CoA; pfam00549
240015006984	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
240015006985	putative active site [active]
240015006986	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
240015006987	active site
240015006988	multimer interface [polypeptide binding]; other site
240015006989	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
240015006990	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240015006991	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240015006992	active site
240015006993	catalytic tetrad [active]
240015006994	Homeodomain-like domain; Region: HTH_23; cl17451
240015006995	Integrase core domain; Region: rve; pfam00665
240015006996	Integrase core domain; Region: rve_3; pfam13683
240015006997	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015006998	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
240015006999	GIY-YIG motif/motif A; other site
240015007000	active site
240015007001	catalytic site [active]
240015007002	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
240015007003	protease TldD; Provisional; Region: tldD; PRK10735
240015007004	metal-dependent hydrolase; Provisional; Region: PRK13291
240015007005	DinB superfamily; Region: DinB_2; pfam12867
240015007006	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
240015007007	PIN domain; Region: PIN_2; pfam10130
240015007008	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
240015007009	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
240015007010	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
240015007011	G1 box; other site
240015007012	putative GEF interaction site [polypeptide binding]; other site
240015007013	GTP/Mg2+ binding site [chemical binding]; other site
240015007014	Switch I region; other site
240015007015	G2 box; other site
240015007016	G3 box; other site
240015007017	Switch II region; other site
240015007018	G4 box; other site
240015007019	G5 box; other site
240015007020	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
240015007021	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
240015007022	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
240015007023	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015007024	non-specific DNA binding site [nucleotide binding]; other site
240015007025	salt bridge; other site
240015007026	sequence-specific DNA binding site [nucleotide binding]; other site
240015007027	Cupin domain; Region: Cupin_2; pfam07883
240015007028	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
240015007029	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015007030	NAD(P) binding site [chemical binding]; other site
240015007031	active site
240015007032	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
240015007033	Interdomain contacts; other site
240015007034	Cytokine receptor motif; other site
240015007035	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
240015007036	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
240015007037	transaldolase-like protein; Provisional; Region: PTZ00411
240015007038	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
240015007039	active site
240015007040	dimer interface [polypeptide binding]; other site
240015007041	catalytic residue [active]
240015007042	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
240015007043	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
240015007044	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
240015007045	active site
240015007046	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
240015007047	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
240015007048	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240015007049	catalytic triad [active]
240015007050	CRISPR/Cas system-associated protein Csa8a2; Region: Cas8a2_I-A; cl09872
240015007051	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
240015007052	N-acetyl-D-glucosamine binding site [chemical binding]; other site
240015007053	catalytic residue [active]
240015007054	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
240015007055	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
240015007056	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
240015007057	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
240015007058	GTP-binding protein LepA; Provisional; Region: PRK05433
240015007059	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
240015007060	G1 box; other site
240015007061	putative GEF interaction site [polypeptide binding]; other site
240015007062	GTP/Mg2+ binding site [chemical binding]; other site
240015007063	Switch I region; other site
240015007064	G2 box; other site
240015007065	G3 box; other site
240015007066	Switch II region; other site
240015007067	G4 box; other site
240015007068	G5 box; other site
240015007069	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
240015007070	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
240015007071	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
240015007072	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
240015007073	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
240015007074	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
240015007075	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
240015007076	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
240015007077	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
240015007078	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015007079	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015007080	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
240015007081	FtsX-like permease family; Region: FtsX; pfam02687
240015007082	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
240015007083	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
240015007084	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
240015007085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015007086	peptide chain release factor 1; Validated; Region: prfA; PRK00591
240015007087	This domain is found in peptide chain release factors; Region: PCRF; smart00937
240015007088	RF-1 domain; Region: RF-1; pfam00472
240015007089	ATP-dependent DNA ligase; Validated; Region: PRK09247
240015007090	Adenylation domain of ATP-dependent DNA Ligases; Region: Adenylation_DNA_ligase; cd07898
240015007091	active site
240015007092	DNA binding site [nucleotide binding]
240015007093	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
240015007094	DNA binding site [nucleotide binding]
240015007095	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
240015007096	active site
240015007097	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
240015007098	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
240015007099	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
240015007100	active site
240015007101	HslU subunit interaction site [polypeptide binding]; other site
240015007102	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
240015007103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015007104	Walker A motif; other site
240015007105	ATP binding site [chemical binding]; other site
240015007106	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
240015007107	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
240015007108	Homeodomain-like domain; Region: HTH_23; cl17451
240015007109	Integrase core domain; Region: rve; pfam00665
240015007110	Integrase core domain; Region: rve_3; pfam13683
240015007111	Domain of unknown function (DUF202); Region: DUF202; cl09954
240015007112	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
240015007113	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
240015007114	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
240015007115	Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A; Region: PNGaseA; pfam12222
240015007116	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
240015007117	manganese transport protein MntH; Reviewed; Region: PRK00701
240015007118	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
240015007119	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
240015007120	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
240015007121	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
240015007122	FeoA domain; Region: FeoA; pfam04023
240015007123	Putative zinc-finger; Region: zf-HC2; pfam13490
240015007124	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
240015007125	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015007126	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015007127	DNA binding residues [nucleotide binding]
240015007128	Predicted membrane protein [Function unknown]; Region: COG2259
240015007129	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262
240015007130	hypothetical protein; Provisional; Region: PRK05409
240015007131	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015007132	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
240015007133	putative pectinesterase; Region: PLN02432; cl01911
240015007134	Pectinesterase; Region: Pectinesterase; pfam01095
240015007135	Transcriptional regulators [Transcription]; Region: GntR; COG1802
240015007136	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
240015007137	DNA-binding site [nucleotide binding]; DNA binding site
240015007138	FCD domain; Region: FCD; pfam07729
240015007139	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
240015007140	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
240015007141	D-mannonate oxidoreductase; Provisional; Region: PRK08277
240015007142	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015007143	NAD(P) binding site [chemical binding]; other site
240015007144	active site
240015007145	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
240015007146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015007147	D-galactonate transporter; Region: 2A0114; TIGR00893
240015007148	putative substrate translocation pore; other site
240015007149	glucuronate isomerase; Reviewed; Region: PRK02925
240015007150	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
240015007151	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
240015007152	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
240015007153	dimer interface [polypeptide binding]; other site
240015007154	PYR/PP interface [polypeptide binding]; other site
240015007155	TPP binding site [chemical binding]; other site
240015007156	substrate binding site [chemical binding]; other site
240015007157	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
240015007158	Domain of unknown function; Region: EKR; pfam10371
240015007159	4Fe-4S binding domain; Region: Fer4_6; pfam12837
240015007160	4Fe-4S binding domain; Region: Fer4; pfam00037
240015007161	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
240015007162	TPP-binding site [chemical binding]; other site
240015007163	dimer interface [polypeptide binding]; other site
240015007164	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
240015007165	RNA binding surface [nucleotide binding]; other site
240015007166	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
240015007167	Protein kinase domain; Region: Pkinase; pfam00069
240015007168	Catalytic domain of Protein Kinases; Region: PKc; cd00180
240015007169	active site
240015007170	ATP binding site [chemical binding]; other site
240015007171	substrate binding site [chemical binding]; other site
240015007172	activation loop (A-loop); other site
240015007173	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015007174	TPR motif; other site
240015007175	binding surface
240015007176	TPR repeat; Region: TPR_11; pfam13414
240015007177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015007178	binding surface
240015007179	TPR motif; other site
240015007180	TPR repeat; Region: TPR_11; pfam13414
240015007181	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015007182	TPR motif; other site
240015007183	binding surface
240015007184	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240015007185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015007186	dimer interface [polypeptide binding]; other site
240015007187	phosphorylation site [posttranslational modification]
240015007188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015007189	ATP binding site [chemical binding]; other site
240015007190	Mg2+ binding site [ion binding]; other site
240015007191	G-X-G motif; other site
240015007192	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240015007193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015007194	active site
240015007195	phosphorylation site [posttranslational modification]
240015007196	intermolecular recognition site; other site
240015007197	dimerization interface [polypeptide binding]; other site
240015007198	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240015007199	DNA binding site [nucleotide binding]
240015007200	Pectinesterase; Region: Pectinesterase; pfam01095
240015007201	putative pectinesterase; Region: PLN02432; cl01911
240015007202	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
240015007203	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240015007204	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
240015007205	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015007206	FeS/SAM binding site; other site
240015007207	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
240015007208	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
240015007209	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
240015007210	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015007211	FeS/SAM binding site; other site
240015007212	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
240015007213	active site
240015007214	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
240015007215	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
240015007216	Soluble P-type ATPase [General function prediction only]; Region: COG4087
240015007217	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
240015007218	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240015007219	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240015007220	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674
240015007221	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
240015007222	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
240015007223	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
240015007224	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
240015007225	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015007226	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
240015007227	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
240015007228	acyl-activating enzyme (AAE) consensus motif; other site
240015007229	AMP binding site [chemical binding]; other site
240015007230	active site
240015007231	CoA binding site [chemical binding]; other site
240015007232	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
240015007233	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240015007234	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
240015007235	putative acyl-acceptor binding pocket; other site
240015007236	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
240015007237	RNB domain; Region: RNB; pfam00773
240015007238	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
240015007239	RNA binding site [nucleotide binding]; other site
240015007240	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
240015007241	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
240015007242	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
240015007243	Glutamate binding site [chemical binding]; other site
240015007244	homodimer interface [polypeptide binding]; other site
240015007245	NAD binding site [chemical binding]; other site
240015007246	catalytic residues [active]
240015007247	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015007248	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015007249	DNA binding residues [nucleotide binding]
240015007250	dimerization interface [polypeptide binding]; other site
240015007251	Response regulator receiver domain; Region: Response_reg; pfam00072
240015007252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015007253	active site
240015007254	phosphorylation site [posttranslational modification]
240015007255	intermolecular recognition site; other site
240015007256	dimerization interface [polypeptide binding]; other site
240015007257	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
240015007258	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
240015007259	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240015007260	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240015007261	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240015007262	ligand binding site [chemical binding]; other site
240015007263	flexible hinge region; other site
240015007264	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240015007265	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015007266	ATP binding site [chemical binding]; other site
240015007267	Mg2+ binding site [ion binding]; other site
240015007268	G-X-G motif; other site
240015007269	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
240015007270	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
240015007271	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
240015007272	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
240015007273	ligand binding site [chemical binding]; other site
240015007274	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
240015007275	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
240015007276	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
240015007277	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
240015007278	phosphopeptide binding site; other site
240015007279	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240015007280	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
240015007281	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
240015007282	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015007283	Phosphoesterase family; Region: Phosphoesterase; pfam04185
240015007284	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
240015007285	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
240015007286	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
240015007287	active site
240015007288	catalytic site [active]
240015007289	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
240015007290	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
240015007291	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
240015007292	catalytic site [active]
240015007293	active site
240015007294	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
240015007295	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
240015007296	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
240015007297	Phosphoesterase family; Region: Phosphoesterase; pfam04185
240015007298	Phosphoesterase family; Region: Phosphoesterase; pfam04185
240015007299	Phosphoesterase family; Region: Phosphoesterase; pfam04185
240015007300	Domain of unknown function (DUF756); Region: DUF756; pfam05506
240015007301	Domain of unknown function (DUF756); Region: DUF756; pfam05506
240015007302	mercuric reductase; Validated; Region: PRK06370
240015007303	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
240015007304	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240015007305	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
240015007306	acid sphingomyelinase and related proteins, metallophosphatase domain; Region: MPP_ASMase; cd00842
240015007307	putative active site [active]
240015007308	putative metal binding site [ion binding]; other site
240015007309	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
240015007310	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
240015007311	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
240015007312	trimer interface [polypeptide binding]; other site
240015007313	active site
240015007314	substrate binding site [chemical binding]; other site
240015007315	CoA binding site [chemical binding]; other site
240015007316	cysteine synthase; Region: PLN02565
240015007317	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
240015007318	dimer interface [polypeptide binding]; other site
240015007319	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015007320	catalytic residue [active]
240015007321	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240015007322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015007323	Walker A/P-loop; other site
240015007324	ATP binding site [chemical binding]; other site
240015007325	Q-loop/lid; other site
240015007326	ABC transporter signature motif; other site
240015007327	Walker B; other site
240015007328	D-loop; other site
240015007329	H-loop/switch region; other site
240015007330	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
240015007331	Putative glucoamylase; Region: Glycoamylase; pfam10091
240015007332	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015007333	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
240015007334	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
240015007335	dimer interface [polypeptide binding]; other site
240015007336	NADP binding site [chemical binding]; other site
240015007337	catalytic residues [active]
240015007338	Transcriptional regulators [Transcription]; Region: GntR; COG1802
240015007339	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
240015007340	DNA-binding site [nucleotide binding]; DNA binding site
240015007341	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
240015007342	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
240015007343	malate dehydrogenase; Provisional; Region: PRK13529
240015007344	Malic enzyme, N-terminal domain; Region: malic; pfam00390
240015007345	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
240015007346	NAD(P) binding site [chemical binding]; other site
240015007347	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
240015007348	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
240015007349	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
240015007350	Domain of unknown function (DUF303); Region: DUF303; pfam03629
240015007351	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
240015007352	Domain of unknown function (DUF303); Region: DUF303; pfam03629
240015007353	Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206
240015007354	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
240015007355	Lamin Tail Domain; Region: LTD; pfam00932
240015007356	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
240015007357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015007358	ATP binding site [chemical binding]; other site
240015007359	Mg2+ binding site [ion binding]; other site
240015007360	G-X-G motif; other site
240015007361	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
240015007362	anchoring element; other site
240015007363	dimer interface [polypeptide binding]; other site
240015007364	ATP binding site [chemical binding]; other site
240015007365	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
240015007366	active site
240015007367	putative metal-binding site [ion binding]; other site
240015007368	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
240015007369	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
240015007370	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
240015007371	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
240015007372	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
240015007373	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015007374	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
240015007375	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
240015007376	dimer interface [polypeptide binding]; other site
240015007377	Homeodomain-like domain; Region: HTH_23; cl17451
240015007378	Integrase core domain; Region: rve; pfam00665
240015007379	Integrase core domain; Region: rve_3; pfam13683
240015007380	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
240015007381	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
240015007382	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
240015007383	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
240015007384	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
240015007385	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
240015007386	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
240015007387	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240015007388	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015007389	putative active site [active]
240015007390	heme pocket [chemical binding]; other site
240015007391	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240015007392	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015007393	putative active site [active]
240015007394	heme pocket [chemical binding]; other site
240015007395	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015007396	dimer interface [polypeptide binding]; other site
240015007397	phosphorylation site [posttranslational modification]
240015007398	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015007399	ATP binding site [chemical binding]; other site
240015007400	Mg2+ binding site [ion binding]; other site
240015007401	G-X-G motif; other site
240015007402	Homeodomain-like domain; Region: HTH_23; cl17451
240015007403	Integrase core domain; Region: rve; pfam00665
240015007404	Integrase core domain; Region: rve_3; pfam13683
240015007405	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
240015007406	Gram-negative bacterial tonB protein; Region: TonB; cl10048
240015007407	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
240015007408	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
240015007409	putative deacylase active site [active]
240015007410	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240015007411	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
240015007412	Walker A/P-loop; other site
240015007413	ATP binding site [chemical binding]; other site
240015007414	Q-loop/lid; other site
240015007415	ABC transporter signature motif; other site
240015007416	Walker B; other site
240015007417	D-loop; other site
240015007418	H-loop/switch region; other site
240015007419	CcmE; Region: CcmE; cl00994
240015007420	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
240015007421	ThiC family; Region: ThiC; pfam01964
240015007422	YtxH-like protein; Region: YtxH; pfam12732
240015007423	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
240015007424	Clp amino terminal domain; Region: Clp_N; pfam02861
240015007425	Clp amino terminal domain; Region: Clp_N; pfam02861
240015007426	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015007427	Walker A motif; other site
240015007428	ATP binding site [chemical binding]; other site
240015007429	Walker B motif; other site
240015007430	arginine finger; other site
240015007431	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015007432	Walker A motif; other site
240015007433	ATP binding site [chemical binding]; other site
240015007434	Walker B motif; other site
240015007435	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
240015007436	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
240015007437	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
240015007438	Walker A/P-loop; other site
240015007439	ATP binding site [chemical binding]; other site
240015007440	Q-loop/lid; other site
240015007441	ABC transporter signature motif; other site
240015007442	Walker B; other site
240015007443	D-loop; other site
240015007444	H-loop/switch region; other site
240015007445	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
240015007446	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
240015007447	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015007448	FtsX-like permease family; Region: FtsX; pfam02687
240015007449	FOG: WD40 repeat [General function prediction only]; Region: COG2319
240015007450	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
240015007451	structural tetrad; other site
240015007452	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
240015007453	Interdomain contacts; other site
240015007454	Cytokine receptor motif; other site
240015007455	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
240015007456	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240015007457	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240015007458	metal ion-dependent adhesion site (MIDAS); other site
240015007459	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
240015007460	N- and C-terminal domain interface [polypeptide binding]; other site
240015007461	D-xylulose kinase; Region: XylB; TIGR01312
240015007462	active site
240015007463	MgATP binding site [chemical binding]; other site
240015007464	catalytic site [active]
240015007465	metal binding site [ion binding]; metal-binding site
240015007466	xylulose binding site [chemical binding]; other site
240015007467	homodimer interface [polypeptide binding]; other site
240015007468	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
240015007469	dimer interface [polypeptide binding]; other site
240015007470	ADP-ribose binding site [chemical binding]; other site
240015007471	active site
240015007472	nudix motif; other site
240015007473	metal binding site [ion binding]; metal-binding site
240015007474	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
240015007475	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015007476	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015007477	Response regulator receiver domain; Region: Response_reg; pfam00072
240015007478	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015007479	active site
240015007480	phosphorylation site [posttranslational modification]
240015007481	intermolecular recognition site; other site
240015007482	dimerization interface [polypeptide binding]; other site
240015007483	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
240015007484	Cytochrome C biogenesis protein; Region: CcmH; cl01179
240015007485	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
240015007486	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015007487	phosphoglycolate phosphatase; Provisional; Region: PRK13222
240015007488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015007489	motif II; other site
240015007490	excinuclease ABC subunit B; Provisional; Region: PRK05298
240015007491	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240015007492	ATP binding site [chemical binding]; other site
240015007493	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240015007494	nucleotide binding region [chemical binding]; other site
240015007495	ATP-binding site [chemical binding]; other site
240015007496	Ultra-violet resistance protein B; Region: UvrB; pfam12344
240015007497	ribulokinase; Provisional; Region: PRK04123
240015007498	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
240015007499	nucleotide binding site [chemical binding]; other site
240015007500	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
240015007501	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
240015007502	hexamer (dimer of trimers) interface [polypeptide binding]; other site
240015007503	substrate binding site [chemical binding]; other site
240015007504	trimer interface [polypeptide binding]; other site
240015007505	Mn binding site [ion binding]; other site
240015007506	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
240015007507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015007508	putative substrate translocation pore; other site
240015007509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015007510	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
240015007511	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
240015007512	intersubunit interface [polypeptide binding]; other site
240015007513	active site
240015007514	Zn2+ binding site [ion binding]; other site
240015007515	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
240015007516	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
240015007517	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
240015007518	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
240015007519	Transcriptional regulators [Transcription]; Region: PurR; COG1609
240015007520	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
240015007521	DNA binding site [nucleotide binding]
240015007522	domain linker motif; other site
240015007523	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
240015007524	ligand binding site [chemical binding]; other site
240015007525	dimerization interface [polypeptide binding]; other site
240015007526	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
240015007527	active site
240015007528	catalytic residues [active]
240015007529	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
240015007530	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
240015007531	NAD(P) binding site [chemical binding]; other site
240015007532	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015007533	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015007534	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015007535	VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436
240015007536	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
240015007537	metal ion-dependent adhesion site (MIDAS); other site
240015007538	Ferritin-like domain; Region: Ferritin_2; pfam13668
240015007539	Ferritin-like domain; Region: Ferritin_2; pfam13668
240015007540	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
240015007541	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
240015007542	RNA/DNA hybrid binding site [nucleotide binding]; other site
240015007543	active site
240015007544	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
240015007545	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
240015007546	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
240015007547	active site
240015007548	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
240015007549	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
240015007550	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
240015007551	RimM N-terminal domain; Region: RimM; pfam01782
240015007552	PRC-barrel domain; Region: PRC; pfam05239
240015007553	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
240015007554	KH domain; Region: KH_4; pfam13083
240015007555	G-X-X-G motif; other site
240015007556	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
240015007557	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240015007558	GAF domain; Region: GAF; pfam01590
240015007559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015007560	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
240015007561	putative active site [active]
240015007562	heme pocket [chemical binding]; other site
240015007563	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015007564	putative active site [active]
240015007565	heme pocket [chemical binding]; other site
240015007566	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
240015007567	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
240015007568	putative active site [active]
240015007569	heme pocket [chemical binding]; other site
240015007570	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015007571	dimer interface [polypeptide binding]; other site
240015007572	phosphorylation site [posttranslational modification]
240015007573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015007574	ATP binding site [chemical binding]; other site
240015007575	Mg2+ binding site [ion binding]; other site
240015007576	G-X-G motif; other site
240015007577	acetyl-CoA synthetase; Provisional; Region: PRK00174
240015007578	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
240015007579	active site
240015007580	CoA binding site [chemical binding]; other site
240015007581	acyl-activating enzyme (AAE) consensus motif; other site
240015007582	AMP binding site [chemical binding]; other site
240015007583	acetate binding site [chemical binding]; other site
240015007584	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
240015007585	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
240015007586	Ligand binding site; other site
240015007587	oligomer interface; other site
240015007588	putative sialic acid transporter; Region: 2A0112; TIGR00891
240015007589	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015007590	putative substrate translocation pore; other site
240015007591	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015007592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015007593	active site
240015007594	phosphorylation site [posttranslational modification]
240015007595	intermolecular recognition site; other site
240015007596	dimerization interface [polypeptide binding]; other site
240015007597	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015007598	DNA binding residues [nucleotide binding]
240015007599	dimerization interface [polypeptide binding]; other site
240015007600	PilZ domain; Region: PilZ; pfam07238
240015007601	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240015007602	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240015007603	active site
240015007604	catalytic tetrad [active]
240015007605	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
240015007606	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
240015007607	TPP-binding site; other site
240015007608	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
240015007609	PYR/PP interface [polypeptide binding]; other site
240015007610	dimer interface [polypeptide binding]; other site
240015007611	TPP binding site [chemical binding]; other site
240015007612	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
240015007613	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
240015007614	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
240015007615	dimer interface [polypeptide binding]; other site
240015007616	active site
240015007617	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
240015007618	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
240015007619	active site
240015007620	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
240015007621	peptidase domain interface [polypeptide binding]; other site
240015007622	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
240015007623	active site
240015007624	catalytic residues [active]
240015007625	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
240015007626	catalytic residues [active]
240015007627	Predicted acyl esterases [General function prediction only]; Region: COG2936
240015007628	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
240015007629	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858
240015007630	ribonuclease PH; Reviewed; Region: rph; PRK00173
240015007631	Ribonuclease PH; Region: RNase_PH_bact; cd11362
240015007632	hexamer interface [polypeptide binding]; other site
240015007633	active site
240015007634	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
240015007635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015007636	active site
240015007637	phosphorylation site [posttranslational modification]
240015007638	intermolecular recognition site; other site
240015007639	dimerization interface [polypeptide binding]; other site
240015007640	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015007641	Walker A motif; other site
240015007642	ATP binding site [chemical binding]; other site
240015007643	Walker B motif; other site
240015007644	arginine finger; other site
240015007645	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
240015007646	Predicted acetyltransferase [General function prediction only]; Region: COG3393
240015007647	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240015007648	Coenzyme A binding pocket [chemical binding]; other site
240015007649	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
240015007650	Transglycosylase; Region: Transgly; pfam00912
240015007651	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
240015007652	prolyl-tRNA synthetase; Provisional; Region: PRK09194
240015007653	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
240015007654	dimer interface [polypeptide binding]; other site
240015007655	motif 1; other site
240015007656	active site
240015007657	motif 2; other site
240015007658	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
240015007659	putative deacylase active site [active]
240015007660	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
240015007661	active site
240015007662	motif 3; other site
240015007663	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
240015007664	anticodon binding site; other site
240015007665	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
240015007666	active site
240015007667	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
240015007668	putative active site [active]
240015007669	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
240015007670	B12 binding site [chemical binding]; other site
240015007671	cobalt ligand [ion binding]; other site
240015007672	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240015007673	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240015007674	DNA binding site [nucleotide binding]
240015007675	Predicted ATPase [General function prediction only]; Region: COG3899
240015007676	AAA ATPase domain; Region: AAA_16; pfam13191
240015007677	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
240015007678	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
240015007679	substrate binding pocket [chemical binding]; other site
240015007680	chain length determination region; other site
240015007681	substrate-Mg2+ binding site; other site
240015007682	catalytic residues [active]
240015007683	aspartate-rich region 1; other site
240015007684	active site lid residues [active]
240015007685	aspartate-rich region 2; other site
240015007686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
240015007687	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
240015007688	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
240015007689	active site
240015007690	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
240015007691	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
240015007692	active site
240015007693	HIGH motif; other site
240015007694	KMSKS motif; other site
240015007695	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
240015007696	tRNA binding surface [nucleotide binding]; other site
240015007697	anticodon binding site; other site
240015007698	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
240015007699	dimer interface [polypeptide binding]; other site
240015007700	putative tRNA-binding site [nucleotide binding]; other site
240015007701	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
240015007702	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
240015007703	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
240015007704	active site
240015007705	HIGH motif; other site
240015007706	nucleotide binding site [chemical binding]; other site
240015007707	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
240015007708	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
240015007709	tRNA binding surface [nucleotide binding]; other site
240015007710	anticodon binding site; other site
240015007711	Bax inhibitor 1 like; Region: BaxI_1; cl17691
240015007712	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
240015007713	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
240015007714	dimer interface [polypeptide binding]; other site
240015007715	active site
240015007716	glycine-pyridoxal phosphate binding site [chemical binding]; other site
240015007717	folate binding site [chemical binding]; other site
240015007718	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
240015007719	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
240015007720	GatB domain; Region: GatB_Yqey; smart00845
240015007721	Peptidase family M48; Region: Peptidase_M48; cl12018
240015007722	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
240015007723	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
240015007724	Sporulation related domain; Region: SPOR; pfam05036
240015007725	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
240015007726	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015007727	FeS/SAM binding site; other site
240015007728	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
240015007729	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240015007730	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
240015007731	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
240015007732	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
240015007733	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
240015007734	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
240015007735	Penicillinase repressor; Region: Pencillinase_R; pfam03965
240015007736	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
240015007737	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
240015007738	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
240015007739	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
240015007740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015007741	active site
240015007742	phosphorylation site [posttranslational modification]
240015007743	intermolecular recognition site; other site
240015007744	dimerization interface [polypeptide binding]; other site
240015007745	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
240015007746	DNA binding site [nucleotide binding]
240015007747	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240015007748	dimerization interface [polypeptide binding]; other site
240015007749	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
240015007750	dimer interface [polypeptide binding]; other site
240015007751	phosphorylation site [posttranslational modification]
240015007752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015007753	ATP binding site [chemical binding]; other site
240015007754	Mg2+ binding site [ion binding]; other site
240015007755	G-X-G motif; other site
240015007756	potassium uptake protein; Region: kup; TIGR00794
240015007757	K+ potassium transporter; Region: K_trans; pfam02705
240015007758	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
240015007759	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
240015007760	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
240015007761	active site
240015007762	substrate-binding site [chemical binding]; other site
240015007763	metal-binding site [ion binding]
240015007764	ATP binding site [chemical binding]; other site
240015007765	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
240015007766	active site
240015007767	Acylphosphatase; Region: Acylphosphatase; pfam00708
240015007768	single-stranded binding protein UL29; Provisional; Region: PHA03362
240015007769	HEPN domain; Region: HEPN; cl00824
240015007770	elongation factor P; Validated; Region: PRK00529
240015007771	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
240015007772	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
240015007773	RNA binding site [nucleotide binding]; other site
240015007774	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
240015007775	RNA binding site [nucleotide binding]; other site
240015007776	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
240015007777	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
240015007778	glutamine binding [chemical binding]; other site
240015007779	catalytic triad [active]
240015007780	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
240015007781	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
240015007782	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
240015007783	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
240015007784	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
240015007785	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
240015007786	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
240015007787	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
240015007788	NAD(P) binding site [chemical binding]; other site
240015007789	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
240015007790	oligomeric interface; other site
240015007791	homodimer interface [polypeptide binding]; other site
240015007792	putative active site [active]
240015007793	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
240015007794	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
240015007795	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
240015007796	Zn2+ binding site [ion binding]; other site
240015007797	Mg2+ binding site [ion binding]; other site
240015007798	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
240015007799	synthetase active site [active]
240015007800	NTP binding site [chemical binding]; other site
240015007801	metal binding site [ion binding]; metal-binding site
240015007802	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
240015007803	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
240015007804	hypothetical protein; Validated; Region: PRK07411
240015007805	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
240015007806	ATP binding site [chemical binding]; other site
240015007807	substrate interface [chemical binding]; other site
240015007808	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
240015007809	active site residue [active]
240015007810	Ubiquitin-like proteins; Region: UBQ; cl00155
240015007811	charged pocket; other site
240015007812	hydrophobic patch; other site
240015007813	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
240015007814	MPN+ (JAMM) motif; other site
240015007815	Zinc-binding site [ion binding]; other site
240015007816	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
240015007817	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
240015007818	dimer interface [polypeptide binding]; other site
240015007819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015007820	catalytic residue [active]
240015007821	CAAX protease self-immunity; Region: Abi; pfam02517
240015007822	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
240015007823	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
240015007824	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
240015007825	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
240015007826	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
240015007827	dimer interface [polypeptide binding]; other site
240015007828	FMN binding site [chemical binding]; other site
240015007829	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
240015007830	nudix motif; other site
240015007831	Predicted methyltransferases [General function prediction only]; Region: COG0313
240015007832	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
240015007833	putative SAM binding site [chemical binding]; other site
240015007834	putative homodimer interface [polypeptide binding]; other site
240015007835	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
240015007836	Peptidase family M50; Region: Peptidase_M50; pfam02163
240015007837	active site
240015007838	putative substrate binding region [chemical binding]; other site
240015007839	FOG: CBS domain [General function prediction only]; Region: COG0517
240015007840	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
240015007841	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
240015007842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
240015007843	S-adenosylmethionine binding site [chemical binding]; other site
240015007844	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
240015007845	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
240015007846	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
240015007847	HIGH motif; other site
240015007848	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
240015007849	active site
240015007850	KMSKS motif; other site
240015007851	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
240015007852	thiamine monophosphate kinase; Provisional; Region: PRK05731
240015007853	ATP binding site [chemical binding]; other site
240015007854	dimerization interface [polypeptide binding]; other site
240015007855	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
240015007856	Peptidase family M23; Region: Peptidase_M23; pfam01551
240015007857	elongation factor Tu; Reviewed; Region: PRK00049
240015007858	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
240015007859	G1 box; other site
240015007860	GEF interaction site [polypeptide binding]; other site
240015007861	GTP/Mg2+ binding site [chemical binding]; other site
240015007862	Switch I region; other site
240015007863	G2 box; other site
240015007864	G3 box; other site
240015007865	Switch II region; other site
240015007866	G4 box; other site
240015007867	G5 box; other site
240015007868	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
240015007869	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
240015007870	Antibiotic Binding Site [chemical binding]; other site
240015007871	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
240015007872	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
240015007873	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
240015007874	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
240015007875	putative homodimer interface [polypeptide binding]; other site
240015007876	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
240015007877	heterodimer interface [polypeptide binding]; other site
240015007878	homodimer interface [polypeptide binding]; other site
240015007879	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
240015007880	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
240015007881	23S rRNA interface [nucleotide binding]; other site
240015007882	L7/L12 interface [polypeptide binding]; other site
240015007883	putative thiostrepton binding site; other site
240015007884	L25 interface [polypeptide binding]; other site
240015007885	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
240015007886	mRNA/rRNA interface [nucleotide binding]; other site
240015007887	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
240015007888	23S rRNA interface [nucleotide binding]; other site
240015007889	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
240015007890	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
240015007891	L11 interface [polypeptide binding]; other site
240015007892	putative EF-Tu interaction site [polypeptide binding]; other site
240015007893	putative EF-G interaction site [polypeptide binding]; other site
240015007894	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
240015007895	Double zinc ribbon; Region: DZR; pfam12773
240015007896	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
240015007897	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
240015007898	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
240015007899	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
240015007900	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
240015007901	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
240015007902	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
240015007903	RPB3 interaction site [polypeptide binding]; other site
240015007904	RPB1 interaction site [polypeptide binding]; other site
240015007905	RPB11 interaction site [polypeptide binding]; other site
240015007906	RPB10 interaction site [polypeptide binding]; other site
240015007907	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
240015007908	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
240015007909	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
240015007910	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
240015007911	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
240015007912	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
240015007913	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
240015007914	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
240015007915	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
240015007916	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
240015007917	DNA binding site [nucleotide binding]
240015007918	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
240015007919	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
240015007920	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240015007921	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
240015007922	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
240015007923	THF binding site; other site
240015007924	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
240015007925	substrate binding site [chemical binding]; other site
240015007926	THF binding site; other site
240015007927	zinc-binding site [ion binding]; other site
240015007928	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
240015007929	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
240015007930	active site
240015007931	catalytic tetrad [active]
240015007932	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240015007933	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015007934	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015007935	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
240015007936	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015007937	FeS/SAM binding site; other site
240015007938	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
240015007939	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
240015007940	active site
240015007941	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240015007942	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
240015007943	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
240015007944	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
240015007945	nudix motif; other site
240015007946	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240015007947	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015007948	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
240015007949	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
240015007950	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015007951	putative substrate translocation pore; other site
240015007952	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015007953	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
240015007954	23S rRNA interface [nucleotide binding]; other site
240015007955	L3 interface [polypeptide binding]; other site
240015007956	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
240015007957	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
240015007958	rRNA interaction site [nucleotide binding]; other site
240015007959	S8 interaction site; other site
240015007960	putative laminin-1 binding site; other site
240015007961	elongation factor Ts; Reviewed; Region: tsf; PRK12332
240015007962	UBA/TS-N domain; Region: UBA; pfam00627
240015007963	Elongation factor TS; Region: EF_TS; pfam00889
240015007964	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
240015007965	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
240015007966	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
240015007967	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
240015007968	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
240015007969	protein binding site [polypeptide binding]; other site
240015007970	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
240015007971	Domain interface; other site
240015007972	Peptide binding site; other site
240015007973	Active site tetrad [active]
240015007974	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
240015007975	putative nucleotide binding site [chemical binding]; other site
240015007976	uridine monophosphate binding site [chemical binding]; other site
240015007977	homohexameric interface [polypeptide binding]; other site
240015007978	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
240015007979	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
240015007980	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
240015007981	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
240015007982	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
240015007983	active site
240015007984	Zn binding site [ion binding]; other site
240015007985	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
240015007986	mce related protein; Region: MCE; pfam02470
240015007987	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
240015007988	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
240015007989	PA14 domain; Region: PA14; cl08459
240015007990	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
240015007991	PBP superfamily domain; Region: PBP_like_2; cl17296
240015007992	multifunctional aminopeptidase A; Provisional; Region: PRK00913
240015007993	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
240015007994	interface (dimer of trimers) [polypeptide binding]; other site
240015007995	Substrate-binding/catalytic site; other site
240015007996	Zn-binding sites [ion binding]; other site
240015007997	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
240015007998	SmpB-tmRNA interface; other site
240015007999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015008000	TPR repeat; Region: TPR_11; pfam13414
240015008001	binding surface
240015008002	TPR motif; other site
240015008003	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
240015008004	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
240015008005	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
240015008006	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
240015008007	dockerin binding interface; other site
240015008008	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
240015008009	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
240015008010	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
240015008011	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
240015008012	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
240015008013	urocanate hydratase; Provisional; Region: PRK05414
240015008014	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
240015008015	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
240015008016	G1 box; other site
240015008017	GTP/Mg2+ binding site [chemical binding]; other site
240015008018	Switch I region; other site
240015008019	G2 box; other site
240015008020	G3 box; other site
240015008021	Switch II region; other site
240015008022	G4 box; other site
240015008023	G5 box; other site
240015008024	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
240015008025	Ligand Binding Site [chemical binding]; other site
240015008026	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
240015008027	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
240015008028	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
240015008029	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
240015008030	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
240015008031	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
240015008032	heterodimer interface [polypeptide binding]; other site
240015008033	active site
240015008034	FMN binding site [chemical binding]; other site
240015008035	homodimer interface [polypeptide binding]; other site
240015008036	substrate binding site [chemical binding]; other site
240015008037	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
240015008038	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
240015008039	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
240015008040	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
240015008041	active site
240015008042	homotetramer interface [polypeptide binding]; other site
240015008043	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
240015008044	anti sigma factor interaction site; other site
240015008045	regulatory phosphorylation site [posttranslational modification]; other site
240015008046	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
240015008047	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
240015008048	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
240015008049	MgtE intracellular N domain; Region: MgtE_N; cl15244
240015008050	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
240015008051	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
240015008052	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
240015008053	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
240015008054	active site
240015008055	8-oxo-dGMP binding site [chemical binding]; other site
240015008056	nudix motif; other site
240015008057	metal binding site [ion binding]; metal-binding site
240015008058	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
240015008059	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
240015008060	intersubunit interface [polypeptide binding]; other site
240015008061	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
240015008062	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
240015008063	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240015008064	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
240015008065	active site
240015008066	DNA binding site [nucleotide binding]
240015008067	Int/Topo IB signature motif; other site
240015008068	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
240015008069	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240015008070	active site
240015008071	DNA binding site [nucleotide binding]
240015008072	Int/Topo IB signature motif; other site
240015008073	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
240015008074	DEAD/DEAH box helicase; Region: DEAD; pfam00270
240015008075	ATP binding site [chemical binding]; other site
240015008076	putative Mg++ binding site [ion binding]; other site
240015008077	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
240015008078	SEC-C motif; Region: SEC-C; pfam02810
240015008079	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
240015008080	putative active site [active]
240015008081	putative metal binding residues [ion binding]; other site
240015008082	signature motif; other site
240015008083	putative triphosphate binding site [ion binding]; other site
240015008084	dimer interface [polypeptide binding]; other site
240015008085	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
240015008086	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
240015008087	Sm and related proteins; Region: Sm_like; cl00259
240015008088	heptamer interface [polypeptide binding]; other site
240015008089	Sm1 motif; other site
240015008090	hexamer interface [polypeptide binding]; other site
240015008091	RNA binding site [nucleotide binding]; other site
240015008092	Sm2 motif; other site
240015008093	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
240015008094	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
240015008095	DNA polymerase III subunit delta'; Validated; Region: PRK08485
240015008096	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
240015008097	Cytochrome P450; Region: p450; pfam00067
240015008098	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
240015008099	thymidylate kinase; Validated; Region: tmk; PRK00698
240015008100	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
240015008101	TMP-binding site; other site
240015008102	ATP-binding site [chemical binding]; other site
240015008103	argininosuccinate lyase; Provisional; Region: PRK00855
240015008104	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
240015008105	active sites [active]
240015008106	tetramer interface [polypeptide binding]; other site
240015008107	ornithine carbamoyltransferase; Provisional; Region: PRK00779
240015008108	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
240015008109	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
240015008110	acetylornithine aminotransferase; Provisional; Region: PRK02627
240015008111	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
240015008112	inhibitor-cofactor binding pocket; inhibition site
240015008113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015008114	catalytic residue [active]
240015008115	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
240015008116	nucleotide binding site [chemical binding]; other site
240015008117	N-acetyl-L-glutamate binding site [chemical binding]; other site
240015008118	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
240015008119	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
240015008120	Arginine repressor [Transcription]; Region: ArgR; COG1438
240015008121	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
240015008122	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
240015008123	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
240015008124	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
240015008125	active site
240015008126	dimer interface [polypeptide binding]; other site
240015008127	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
240015008128	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
240015008129	active site
240015008130	FMN binding site [chemical binding]; other site
240015008131	substrate binding site [chemical binding]; other site
240015008132	3Fe-4S cluster binding site [ion binding]; other site
240015008133	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
240015008134	domain_subunit interface; other site
240015008135	isoleucyl-tRNA synthetase; Region: PLN02843
240015008136	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
240015008137	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015008138	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
240015008139	catalytic residues [active]
240015008140	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
240015008141	substrate binding site [chemical binding]; other site
240015008142	putative active site [active]
240015008143	redox center [active]
240015008144	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
240015008145	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
240015008146	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
240015008147	Walker A/P-loop; other site
240015008148	ATP binding site [chemical binding]; other site
240015008149	Q-loop/lid; other site
240015008150	ABC transporter signature motif; other site
240015008151	Walker B; other site
240015008152	D-loop; other site
240015008153	H-loop/switch region; other site
240015008154	Repair protein; Region: Repair_PSII; pfam04536
240015008155	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
240015008156	Homeodomain-like domain; Region: HTH_23; cl17451
240015008157	Integrase core domain; Region: rve; pfam00665
240015008158	Integrase core domain; Region: rve_3; pfam13683
240015008159	seryl-tRNA synthetase; Provisional; Region: PRK05431
240015008160	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
240015008161	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
240015008162	dimer interface [polypeptide binding]; other site
240015008163	active site
240015008164	motif 1; other site
240015008165	motif 2; other site
240015008166	motif 3; other site
240015008167	Src homology 2 (SH2) domain; Region: SH2; cl15255
240015008168	phosphotyrosine binding pocket [polypeptide binding]; other site
240015008169	hydrophobic binding pocket [polypeptide binding]; other site
240015008170	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
240015008171	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
240015008172	active site
240015008173	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
240015008174	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
240015008175	NodB motif; other site
240015008176	putative active site [active]
240015008177	putative catalytic site [active]
240015008178	putative Zn binding site [ion binding]; other site
240015008179	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
240015008180	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
240015008181	DXD motif; other site
240015008182	Domain of unknown function (DUF4271); Region: DUF4271; pfam14093
240015008183	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
240015008184	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
240015008185	NAD(P) binding site [chemical binding]; other site
240015008186	active site
240015008187	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
240015008188	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
240015008189	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
240015008190	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
240015008191	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
240015008192	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
240015008193	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
240015008194	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
240015008195	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
240015008196	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015008197	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
240015008198	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015008199	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015008200	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
240015008201	putative substrate translocation pore; other site
240015008202	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015008203	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
240015008204	active sites [active]
240015008205	tetramer interface [polypeptide binding]; other site
240015008206	tyrosine decarboxylase; Region: PLN02880
240015008207	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
240015008208	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240015008209	catalytic residue [active]
240015008210	EamA-like transporter family; Region: EamA; cl17759
240015008211	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
240015008212	B12 binding domain; Region: B12-binding; pfam02310
240015008213	B12 binding site [chemical binding]; other site
240015008214	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015008215	FeS/SAM binding site; other site
240015008216	Outer membrane efflux protein; Region: OEP; pfam02321
240015008217	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015008218	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015008219	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015008220	putative membrane fusion protein; Region: TIGR02828
240015008221	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
240015008222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015008223	putative substrate translocation pore; other site
240015008224	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
240015008225	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
240015008226	DXD motif; other site
240015008227	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240015008228	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
240015008229	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
240015008230	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
240015008231	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
240015008232	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
240015008233	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
240015008234	putative catalytic residues [active]
240015008235	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
240015008236	metal binding site 2 [ion binding]; metal-binding site
240015008237	putative DNA binding helix; other site
240015008238	metal binding site 1 [ion binding]; metal-binding site
240015008239	dimer interface [polypeptide binding]; other site
240015008240	structural Zn2+ binding site [ion binding]; other site
240015008241	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
240015008242	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
240015008243	dimer interface [polypeptide binding]; other site
240015008244	decamer (pentamer of dimers) interface [polypeptide binding]; other site
240015008245	catalytic triad [active]
240015008246	peroxidatic and resolving cysteines [active]
240015008247	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
240015008248	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
240015008249	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
240015008250	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
240015008251	dimer interface [polypeptide binding]; other site
240015008252	active site
240015008253	CoA binding pocket [chemical binding]; other site
240015008254	TMAO/DMSO reductase; Reviewed; Region: PRK05363
240015008255	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
240015008256	Moco binding site; other site
240015008257	metal coordination site [ion binding]; other site
240015008258	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
240015008259	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
240015008260	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
240015008261	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
240015008262	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
240015008263	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
240015008264	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
240015008265	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
240015008266	nickel binding site [ion binding]; other site
240015008267	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
240015008268	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
240015008269	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240015008270	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
240015008271	dimerization interface [polypeptide binding]; other site
240015008272	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
240015008273	ATP binding site [chemical binding]; other site
240015008274	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
240015008275	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
240015008276	HupF/HypC family; Region: HupF_HypC; pfam01455
240015008277	Acylphosphatase; Region: Acylphosphatase; pfam00708
240015008278	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
240015008279	HypF finger; Region: zf-HYPF; pfam07503
240015008280	HypF finger; Region: zf-HYPF; pfam07503
240015008281	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
240015008282	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
240015008283	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240015008284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015008285	Major Facilitator Superfamily; Region: MFS_1; pfam07690
240015008286	putative substrate translocation pore; other site
240015008287	enterobactin exporter EntS; Provisional; Region: PRK10489
240015008288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015008289	putative substrate translocation pore; other site
240015008290	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
240015008291	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
240015008292	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
240015008293	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240015008294	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240015008295	ABC transporter; Region: ABC_tran_2; pfam12848
240015008296	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
240015008297	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
240015008298	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
240015008299	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015008300	WHG domain; Region: WHG; pfam13305
240015008301	Protein of unknown function (DUF1593); Region: DUF1593; pfam07632
240015008302	Cadherin repeat-like domain; Region: CA_like; cl15786
240015008303	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
240015008304	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
240015008305	putative substrate binding site [chemical binding]; other site
240015008306	putative ATP binding site [chemical binding]; other site
240015008307	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
240015008308	MarR family; Region: MarR; pfam01047
240015008309	MarR family; Region: MarR_2; cl17246
240015008310	Uncharacterized conserved protein [Function unknown]; Region: COG2353
240015008311	Pirin-related protein [General function prediction only]; Region: COG1741
240015008312	Pirin; Region: Pirin; pfam02678
240015008313	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
240015008314	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
240015008315	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
240015008316	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
240015008317	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
240015008318	FMN binding site [chemical binding]; other site
240015008319	active site
240015008320	catalytic residues [active]
240015008321	substrate binding site [chemical binding]; other site
240015008322	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
240015008323	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
240015008324	phosphoserine phosphatase SerB; Region: serB; TIGR00338
240015008325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015008326	motif II; other site
240015008327	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
240015008328	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
240015008329	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
240015008330	thiamine pyrophosphate protein; Provisional; Region: PRK08273
240015008331	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
240015008332	PYR/PP interface [polypeptide binding]; other site
240015008333	dimer interface [polypeptide binding]; other site
240015008334	tetramer interface [polypeptide binding]; other site
240015008335	TPP binding site [chemical binding]; other site
240015008336	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
240015008337	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
240015008338	TPP-binding site [chemical binding]; other site
240015008339	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
240015008340	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
240015008341	putative active site pocket [active]
240015008342	putative metal binding site [ion binding]; other site
240015008343	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
240015008344	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
240015008345	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
240015008346	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
240015008347	Transglycosylase; Region: Transgly; cl17702
240015008348	argininosuccinate synthase; Validated; Region: PRK05370
240015008349	argininosuccinate synthase; Provisional; Region: PRK13820
240015008350	Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831
240015008351	active site
240015008352	catalytic triad [active]
240015008353	oxyanion hole [active]
240015008354	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
240015008355	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
240015008356	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
240015008357	Helix-hairpin-helix motif; Region: HHH; pfam00633
240015008358	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
240015008359	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
240015008360	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
240015008361	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
240015008362	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
240015008363	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
240015008364	Walker A motif; other site
240015008365	ATP binding site [chemical binding]; other site
240015008366	Walker B motif; other site
240015008367	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
240015008368	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
240015008369	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
240015008370	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
240015008371	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
240015008372	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
240015008373	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
240015008374	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
240015008375	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
240015008376	NAD binding site [chemical binding]; other site
240015008377	putative substrate binding site 2 [chemical binding]; other site
240015008378	putative substrate binding site 1 [chemical binding]; other site
240015008379	active site
240015008380	epoxyqueuosine reductase; Region: TIGR00276
240015008381	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
240015008382	4Fe-4S binding domain; Region: Fer4; cl02805
240015008383	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
240015008384	DNA-binding site [nucleotide binding]; DNA binding site
240015008385	RNA-binding motif; other site
240015008386	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
240015008387	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
240015008388	dimerization interface [polypeptide binding]; other site
240015008389	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
240015008390	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
240015008391	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
240015008392	putative acetyltransferase; Provisional; Region: PRK03624
240015008393	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
240015008394	Coenzyme A binding pocket [chemical binding]; other site
240015008395	Homeodomain-like domain; Region: HTH_23; cl17451
240015008396	Integrase core domain; Region: rve; pfam00665
240015008397	Integrase core domain; Region: rve_3; pfam13683
240015008398	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
240015008399	C-terminal peptidase (prc); Region: prc; TIGR00225
240015008400	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
240015008401	protein binding site [polypeptide binding]; other site
240015008402	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
240015008403	Catalytic dyad [active]
240015008404	SurA N-terminal domain; Region: SurA_N; pfam09312
240015008405	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
240015008406	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
240015008407	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
240015008408	generic binding surface I; other site
240015008409	generic binding surface II; other site
240015008410	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
240015008411	Zn2+ binding site [ion binding]; other site
240015008412	Mg2+ binding site [ion binding]; other site
240015008413	EVE domain; Region: EVE; pfam01878
240015008414	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
240015008415	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
240015008416	Tetramer interface [polypeptide binding]; other site
240015008417	active site
240015008418	FMN-binding site [chemical binding]; other site
240015008419	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
240015008420	active site
240015008421	catalytic residues [active]
240015008422	metal binding site [ion binding]; metal-binding site
240015008423	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
240015008424	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
240015008425	putative active site [active]
240015008426	substrate binding site [chemical binding]; other site
240015008427	putative cosubstrate binding site; other site
240015008428	catalytic site [active]
240015008429	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
240015008430	substrate binding site [chemical binding]; other site
240015008431	NusB family; Region: NusB; pfam01029
240015008432	putative RNA binding site [nucleotide binding]; other site
240015008433	16S rRNA methyltransferase B; Provisional; Region: PRK14902
240015008434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015008435	S-adenosylmethionine binding site [chemical binding]; other site
240015008436	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
240015008437	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
240015008438	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
240015008439	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
240015008440	Cation efflux family; Region: Cation_efflux; pfam01545
240015008441	Cation efflux family; Region: Cation_efflux; cl00316
240015008442	Cation efflux family; Region: Cation_efflux; cl00316
240015008443	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
240015008444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
240015008445	S-adenosylmethionine binding site [chemical binding]; other site
240015008446	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
240015008447	active site
240015008448	dimer interface [polypeptide binding]; other site
240015008449	metal binding site [ion binding]; metal-binding site
240015008450	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
240015008451	L-aspartate oxidase; Provisional; Region: PRK06175
240015008452	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
240015008453	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
240015008454	Isochorismatase family; Region: Isochorismatase; pfam00857
240015008455	catalytic triad [active]
240015008456	metal binding site [ion binding]; metal-binding site
240015008457	conserved cis-peptide bond; other site
240015008458	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
240015008459	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
240015008460	putative active site [active]
240015008461	metal binding site [ion binding]; metal-binding site
240015008462	HNH endonuclease; Region: HNH_5; pfam14279
240015008463	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015008464	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
240015008465	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
240015008466	quinolinate synthetase; Provisional; Region: PRK09375
240015008467	Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969
240015008468	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
240015008469	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
240015008470	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
240015008471	putative active site [active]
240015008472	catalytic triad [active]
240015008473	putative dimer interface [polypeptide binding]; other site
240015008474	Amino acid permease; Region: AA_permease_2; pfam13520
240015008475	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
240015008476	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
240015008477	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015008478	Radical SAM superfamily; Region: Radical_SAM; pfam04055
240015008479	FeS/SAM binding site; other site
240015008480	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
240015008481	Methyltransferase domain; Region: Methyltransf_23; pfam13489
240015008482	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
240015008483	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
240015008484	TPP-binding site [chemical binding]; other site
240015008485	tetramer interface [polypeptide binding]; other site
240015008486	heterodimer interface [polypeptide binding]; other site
240015008487	phosphorylation loop region [posttranslational modification]
240015008488	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
240015008489	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
240015008490	alpha subunit interface [polypeptide binding]; other site
240015008491	TPP binding site [chemical binding]; other site
240015008492	heterodimer interface [polypeptide binding]; other site
240015008493	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
240015008494	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
240015008495	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
240015008496	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
240015008497	Mechanosensitive ion channel; Region: MS_channel; pfam00924
240015008498	Uncharacterized conserved protein [Function unknown]; Region: COG0062
240015008499	putative carbohydrate kinase; Provisional; Region: PRK10565
240015008500	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
240015008501	putative substrate binding site [chemical binding]; other site
240015008502	putative ATP binding site [chemical binding]; other site
240015008503	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
240015008504	signal recognition particle protein; Provisional; Region: PRK10867
240015008505	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
240015008506	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
240015008507	P loop; other site
240015008508	GTP binding site [chemical binding]; other site
240015008509	Signal peptide binding domain; Region: SRP_SPB; pfam02978
240015008510	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
240015008511	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
240015008512	active site
240015008513	DNA binding site [nucleotide binding]
240015008514	Int/Topo IB signature motif; other site
240015008515	Transcriptional regulator [Transcription]; Region: LysR; COG0583
240015008516	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240015008517	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
240015008518	dimerization interface [polypeptide binding]; other site
240015008519	substrate binding pocket [chemical binding]; other site
240015008520	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
240015008521	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
240015008522	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
240015008523	Domain of unknown function DUF87; Region: DUF87; pfam01935
240015008524	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
240015008525	VirB7 interaction site; other site
240015008526	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
240015008527	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
240015008528	VirB8 protein; Region: VirB8; cl01500
240015008529	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015008530	non-specific DNA binding site [nucleotide binding]; other site
240015008531	salt bridge; other site
240015008532	sequence-specific DNA binding site [nucleotide binding]; other site
240015008533	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
240015008534	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
240015008535	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
240015008536	Walker A motif; other site
240015008537	ATP binding site [chemical binding]; other site
240015008538	Walker B motif; other site
240015008539	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
240015008540	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
240015008541	Walker A motif; other site
240015008542	ATP binding site [chemical binding]; other site
240015008543	Walker B motif; other site
240015008544	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
240015008545	TrwC relaxase; Region: TrwC; pfam08751
240015008546	AAA domain; Region: AAA_30; pfam13604
240015008547	Family description; Region: UvrD_C_2; pfam13538
240015008548	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
240015008549	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
240015008550	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015008551	Walker A/P-loop; other site
240015008552	ATP binding site [chemical binding]; other site
240015008553	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015008554	ABC transporter signature motif; other site
240015008555	Walker B; other site
240015008556	D-loop; other site
240015008557	H-loop/switch region; other site
240015008558	putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183
240015008559	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
240015008560	Active Sites [active]
240015008561	DNA sulfur modification protein DndB; Region: DNA_S_dndB; TIGR03233
240015008562	DGQHR domain; Region: DGQHR; TIGR03187
240015008563	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
240015008564	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
240015008565	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
240015008566	catalytic residue [active]
240015008567	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
240015008568	ATP binding site [chemical binding]; other site
240015008569	putative Mg++ binding site [ion binding]; other site
240015008570	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
240015008571	nucleotide binding region [chemical binding]; other site
240015008572	ATP-binding site [chemical binding]; other site
240015008573	DNA-sulfur modification-associated; Region: DndB; cl17621
240015008574	DGQHR domain; Region: DGQHR; TIGR03187
240015008575	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
240015008576	G1 box; other site
240015008577	GTP/Mg2+ binding site [chemical binding]; other site
240015008578	G2 box; other site
240015008579	Switch I region; other site
240015008580	Transposase; Region: DEDD_Tnp_IS110; pfam01548
240015008581	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
240015008582	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
240015008583	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
240015008584	ParB-like nuclease domain; Region: ParBc; pfam02195
240015008585	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
240015008586	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
240015008587	active site
240015008588	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
240015008589	generic binding surface II; other site
240015008590	generic binding surface I; other site
240015008591	Y-family of DNA polymerases; Region: PolY; cl12025
240015008592	active site
240015008593	DNA binding site [nucleotide binding]
240015008594	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
240015008595	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
240015008596	Walker A motif; other site
240015008597	ATP binding site [chemical binding]; other site
240015008598	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
240015008599	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
240015008600	FRG domain; Region: FRG; pfam08867
240015008601	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015008602	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015008603	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015008604	FtsX-like permease family; Region: FtsX; pfam02687
240015008605	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
240015008606	cyclase homology domain; Region: CHD; cd07302
240015008607	nucleotidyl binding site; other site
240015008608	metal binding site [ion binding]; metal-binding site
240015008609	dimer interface [polypeptide binding]; other site
240015008610	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
240015008611	cyclase homology domain; Region: CHD; cd07302
240015008612	nucleotidyl binding site; other site
240015008613	metal binding site [ion binding]; metal-binding site
240015008614	dimer interface [polypeptide binding]; other site
240015008615	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240015008616	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
240015008617	ligand binding site [chemical binding]; other site
240015008618	flexible hinge region; other site
240015008619	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
240015008620	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
240015008621	Beta-lactamase; Region: Beta-lactamase; pfam00144
240015008622	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015008623	transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433
240015008624	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015008625	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015008626	FtsX-like permease family; Region: FtsX; pfam02687
240015008627	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015008628	FtsX-like permease family; Region: FtsX; pfam02687
240015008629	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
240015008630	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
240015008631	putative active site [active]
240015008632	putative NTP binding site [chemical binding]; other site
240015008633	putative nucleic acid binding site [nucleotide binding]; other site
240015008634	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
240015008635	RNA polymerase sigma factor; Provisional; Region: PRK12519
240015008636	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015008637	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
240015008638	DNA binding residues [nucleotide binding]
240015008639	Anti-sigma-K factor rskA; Region: RskA; pfam10099
240015008640	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015008641	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
240015008642	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015008643	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
240015008644	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
240015008645	active site
240015008646	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
240015008647	Ligand Binding Site [chemical binding]; other site
240015008648	Molecular Tunnel; other site
240015008649	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
240015008650	Phosphotransferase enzyme family; Region: APH; pfam01636
240015008651	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
240015008652	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
240015008653	Predicted deacetylase [General function prediction only]; Region: COG3233
240015008654	Protein of unknown function (DUF416); Region: DUF416; cl01166
240015008655	transposase/IS protein; Provisional; Region: PRK09183
240015008656	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015008657	Walker A motif; other site
240015008658	ATP binding site [chemical binding]; other site
240015008659	Walker B motif; other site
240015008660	arginine finger; other site
240015008661	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
240015008662	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
240015008663	Walker A motif; other site
240015008664	ATP binding site [chemical binding]; other site
240015008665	Walker B motif; other site
240015008666	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
240015008667	TrwC relaxase; Region: TrwC; pfam08751
240015008668	AAA domain; Region: AAA_30; pfam13604
240015008669	Family description; Region: UvrD_C_2; pfam13538
240015008670	Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659
240015008671	5' RNA guide strand anchoring site; other site
240015008672	active site
240015008673	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cd01037
240015008674	putative active site [active]
240015008675	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
240015008676	DEAD/DEAH box helicase; Region: DEAD; pfam00270
240015008677	Family description; Region: UvrD_C_2; pfam13538
240015008678	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
240015008679	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
240015008680	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
240015008681	putative active site [active]
240015008682	putative metal-binding site [ion binding]; other site
240015008683	transposase/IS protein; Provisional; Region: PRK09183
240015008684	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015008685	Walker A motif; other site
240015008686	ATP binding site [chemical binding]; other site
240015008687	Walker B motif; other site
240015008688	arginine finger; other site
240015008689	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
240015008690	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
240015008691	dimer interface [polypeptide binding]; other site
240015008692	ssDNA binding site [nucleotide binding]; other site
240015008693	tetramer (dimer of dimers) interface [polypeptide binding]; other site
240015008694	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
240015008695	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
240015008696	Walker A motif; other site
240015008697	ATP binding site [chemical binding]; other site
240015008698	Walker B motif; other site
240015008699	VirB8 protein; Region: VirB8; cl01500
240015008700	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
240015008701	conjugal transfer protein TrbI; Provisional; Region: PRK13881
240015008702	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
240015008703	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
240015008704	VirB7 interaction site; other site
240015008705	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
240015008706	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
240015008707	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
240015008708	Domain of unknown function (DUF955); Region: DUF955; pfam06114
240015008709	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
240015008710	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015008711	non-specific DNA binding site [nucleotide binding]; other site
240015008712	salt bridge; other site
240015008713	sequence-specific DNA binding site [nucleotide binding]; other site
240015008714	sporadically distributed protein, TIGR04141 family; Region: TIGR04141
240015008715	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
240015008716	PIN domain; Region: PIN_3; pfam13470
240015008717	Helix-turn-helix domain; Region: HTH_17; cl17695
240015008718	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
240015008719	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
240015008720	inhibitor site; inhibition site
240015008721	active site
240015008722	dimer interface [polypeptide binding]; other site
240015008723	catalytic residue [active]
240015008724	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
240015008725	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
240015008726	hydroxyglutarate oxidase; Provisional; Region: PRK11728
240015008727	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
240015008728	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
240015008729	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
240015008730	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
240015008731	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015008732	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015008733	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
240015008734	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
240015008735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015008736	putative substrate translocation pore; other site
240015008737	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
240015008738	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
240015008739	putative NAD(P) binding site [chemical binding]; other site
240015008740	catalytic Zn binding site [ion binding]; other site
240015008741	structural Zn binding site [ion binding]; other site
240015008742	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
240015008743	Amidohydrolase; Region: Amidohydro_2; pfam04909
240015008744	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
240015008745	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
240015008746	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
240015008747	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
240015008748	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
240015008749	galactarate dehydratase; Region: galactar-dH20; TIGR03248
240015008750	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
240015008751	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
240015008752	classical (c) SDRs; Region: SDR_c; cd05233
240015008753	NAD(P) binding site [chemical binding]; other site
240015008754	active site
240015008755	short chain dehydrogenase; Provisional; Region: PRK08628
240015008756	classical (c) SDRs; Region: SDR_c; cd05233
240015008757	NAD(P) binding site [chemical binding]; other site
240015008758	active site
240015008759	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
240015008760	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
240015008761	ANTAR domain; Region: ANTAR; pfam03861
240015008762	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
240015008763	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
240015008764	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
240015008765	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
240015008766	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
240015008767	Uncharacterized conserved protein [Function unknown]; Region: COG2308
240015008768	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
240015008769	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
240015008770	active site
240015008771	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
240015008772	nucleoside/Zn binding site; other site
240015008773	dimer interface [polypeptide binding]; other site
240015008774	catalytic motif [active]
240015008775	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
240015008776	EamA-like transporter family; Region: EamA; cl17759
240015008777	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
240015008778	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
240015008779	purine monophosphate binding site [chemical binding]; other site
240015008780	dimer interface [polypeptide binding]; other site
240015008781	putative catalytic residues [active]
240015008782	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
240015008783	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
240015008784	Rhomboid family; Region: Rhomboid; pfam01694
240015008785	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
240015008786	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
240015008787	non-specific DNA binding site [nucleotide binding]; other site
240015008788	salt bridge; other site
240015008789	sequence-specific DNA binding site [nucleotide binding]; other site
240015008790	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
240015008791	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015008792	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
240015008793	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
240015008794	NAD(P) binding site [chemical binding]; other site
240015008795	homotetramer interface [polypeptide binding]; other site
240015008796	homodimer interface [polypeptide binding]; other site
240015008797	active site
240015008798	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
240015008799	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
240015008800	Thymidylate synthase complementing protein; Region: Thy1; cl03630
240015008801	Thymidylate synthase complementing protein; Region: Thy1; cl03630
240015008802	recombinase A; Provisional; Region: recA; PRK09354
240015008803	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
240015008804	hexamer interface [polypeptide binding]; other site
240015008805	Walker A motif; other site
240015008806	ATP binding site [chemical binding]; other site
240015008807	Walker B motif; other site
240015008808	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
240015008809	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
240015008810	active site
240015008811	(T/H)XGH motif; other site
240015008812	aspartate aminotransferase; Provisional; Region: PRK05764
240015008813	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240015008814	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015008815	homodimer interface [polypeptide binding]; other site
240015008816	catalytic residue [active]
240015008817	putative phosphatase; Provisional; Region: PRK11587
240015008818	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
240015008819	motif II; other site
240015008820	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
240015008821	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
240015008822	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
240015008823	dimer interface [polypeptide binding]; other site
240015008824	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
240015008825	active site
240015008826	Fe binding site [ion binding]; other site
240015008827	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
240015008828	PhoU domain; Region: PhoU; pfam01895
240015008829	PhoU domain; Region: PhoU; pfam01895
240015008830	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
240015008831	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
240015008832	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
240015008833	homodimer interface [polypeptide binding]; other site
240015008834	NADP binding site [chemical binding]; other site
240015008835	substrate binding site [chemical binding]; other site
240015008836	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
240015008837	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
240015008838	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
240015008839	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
240015008840	active site
240015008841	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
240015008842	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
240015008843	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
240015008844	malonyl-CoA binding site [chemical binding]; other site
240015008845	dimer interface [polypeptide binding]; other site
240015008846	active site
240015008847	product binding site; other site
240015008848	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
240015008849	cofactor binding site; other site
240015008850	metal binding site [ion binding]; metal-binding site
240015008851	Predicted transcriptional regulators [Transcription]; Region: COG1733
240015008852	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
240015008853	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
240015008854	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
240015008855	NADP binding site [chemical binding]; other site
240015008856	This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901
240015008857	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
240015008858	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
240015008859	substrate binding pocket [chemical binding]; other site
240015008860	catalytic triad [active]
240015008861	P63C domain; Region: P63C; pfam10546
240015008862	ribosome maturation protein RimP; Reviewed; Region: PRK00092
240015008863	Sm and related proteins; Region: Sm_like; cl00259
240015008864	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
240015008865	putative oligomer interface [polypeptide binding]; other site
240015008866	putative RNA binding site [nucleotide binding]; other site
240015008867	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
240015008868	NusA N-terminal domain; Region: NusA_N; pfam08529
240015008869	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
240015008870	RNA binding site [nucleotide binding]; other site
240015008871	homodimer interface [polypeptide binding]; other site
240015008872	NusA-like KH domain; Region: KH_5; pfam13184
240015008873	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
240015008874	G-X-X-G motif; other site
240015008875	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
240015008876	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
240015008877	translation initiation factor IF-2; Region: IF-2; TIGR00487
240015008878	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
240015008879	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
240015008880	G1 box; other site
240015008881	putative GEF interaction site [polypeptide binding]; other site
240015008882	GTP/Mg2+ binding site [chemical binding]; other site
240015008883	Switch I region; other site
240015008884	G2 box; other site
240015008885	G3 box; other site
240015008886	Switch II region; other site
240015008887	G4 box; other site
240015008888	G5 box; other site
240015008889	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
240015008890	Translation-initiation factor 2; Region: IF-2; pfam11987
240015008891	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
240015008892	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
240015008893	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
240015008894	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
240015008895	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
240015008896	Active site cavity [active]
240015008897	catalytic acid [active]
240015008898	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
240015008899	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015008900	FeS/SAM binding site; other site
240015008901	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
240015008902	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
240015008903	IHF - DNA interface [nucleotide binding]; other site
240015008904	IHF dimer interface [polypeptide binding]; other site
240015008905	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
240015008906	trimer interface [polypeptide binding]; other site
240015008907	active site
240015008908	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015008909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015008910	active site
240015008911	phosphorylation site [posttranslational modification]
240015008912	intermolecular recognition site; other site
240015008913	dimerization interface [polypeptide binding]; other site
240015008914	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015008915	DNA binding residues [nucleotide binding]
240015008916	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
240015008917	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
240015008918	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
240015008919	substrate binding pocket [chemical binding]; other site
240015008920	dimer interface [polypeptide binding]; other site
240015008921	inhibitor binding site; inhibition site
240015008922	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
240015008923	B12 binding site [chemical binding]; other site
240015008924	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
240015008925	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
240015008926	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
240015008927	active site
240015008928	SAM binding site [chemical binding]; other site
240015008929	homodimer interface [polypeptide binding]; other site
240015008930	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
240015008931	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015008932	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338
240015008933	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015008934	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
240015008935	Protein export membrane protein; Region: SecD_SecF; cl14618
240015008936	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
240015008937	Protein export membrane protein; Region: SecD_SecF; cl14618
240015008938	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
240015008939	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
240015008940	C-terminal peptidase (prc); Region: prc; TIGR00225
240015008941	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
240015008942	protein binding site [polypeptide binding]; other site
240015008943	Peptidase family S41; Region: Peptidase_S41; pfam03572
240015008944	Active site serine [active]
240015008945	Transglycosylase; Region: Transgly; pfam00912
240015008946	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
240015008947	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
240015008948	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
240015008949	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
240015008950	catalytic residues [active]
240015008951	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
240015008952	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
240015008953	active site
240015008954	Riboflavin kinase; Region: Flavokinase; pfam01687
240015008955	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
240015008956	putative hydrolase; Provisional; Region: PRK02113
240015008957	Domain of unknown function (DUF1844); Region: DUF1844; pfam08899
240015008958	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
240015008959	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
240015008960	Domain of unknown function (DUF955); Region: DUF955; cl01076
240015008961	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
240015008962	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
240015008963	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
240015008964	substrate binding site [chemical binding]; other site
240015008965	ATP binding site [chemical binding]; other site
240015008966	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
240015008967	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
240015008968	MgtC family; Region: MgtC; pfam02308
240015008969	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
240015008970	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
240015008971	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
240015008972	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
240015008973	dimer interface [polypeptide binding]; other site
240015008974	catalytic triad [active]
240015008975	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
240015008976	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
240015008977	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
240015008978	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
240015008979	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240015008980	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
240015008981	putative acyl-acceptor binding pocket; other site
240015008982	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
240015008983	Sporulation related domain; Region: SPOR; pfam05036
240015008984	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
240015008985	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
240015008986	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
240015008987	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
240015008988	dimer interface [polypeptide binding]; other site
240015008989	active site residues [active]
240015008990	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
240015008991	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015008992	binding surface
240015008993	TPR motif; other site
240015008994	TPR repeat; Region: TPR_11; pfam13414
240015008995	TPR repeat; Region: TPR_11; pfam13414
240015008996	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015008997	TPR motif; other site
240015008998	binding surface
240015008999	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
240015009000	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
240015009001	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
240015009002	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
240015009003	ATP-grasp domain; Region: ATP-grasp_4; cl17255
240015009004	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
240015009005	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
240015009006	active site
240015009007	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
240015009008	Chain length determinant protein; Region: Wzz; cl15801
240015009009	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
240015009010	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240015009011	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
240015009012	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
240015009013	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
240015009014	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
240015009015	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
240015009016	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
240015009017	DXD motif; other site
240015009018	O-Antigen ligase; Region: Wzy_C; pfam04932
240015009019	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
240015009020	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
240015009021	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
240015009022	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
240015009023	putative ADP-binding pocket [chemical binding]; other site
240015009024	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
240015009025	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
240015009026	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
240015009027	Probable Catalytic site; other site
240015009028	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
240015009029	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
240015009030	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
240015009031	trimer interface [polypeptide binding]; other site
240015009032	active site
240015009033	substrate binding site [chemical binding]; other site
240015009034	CoA binding site [chemical binding]; other site
240015009035	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
240015009036	threonine synthase; Validated; Region: PRK07591
240015009037	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
240015009038	homodimer interface [polypeptide binding]; other site
240015009039	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015009040	catalytic residue [active]
240015009041	Ubiquitin-like proteins; Region: UBQ; cl00155
240015009042	charged pocket; other site
240015009043	hydrophobic patch; other site
240015009044	aminotransferase; Validated; Region: PRK07777
240015009045	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240015009046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015009047	homodimer interface [polypeptide binding]; other site
240015009048	catalytic residue [active]
240015009049	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
240015009050	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
240015009051	putative acyl-acceptor binding pocket; other site
240015009052	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
240015009053	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
240015009054	trimer interface [polypeptide binding]; other site
240015009055	active site
240015009056	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
240015009057	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
240015009058	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
240015009059	putative NAD(P) binding site [chemical binding]; other site
240015009060	putative active site [active]
240015009061	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
240015009062	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
240015009063	amino acid transporter; Region: 2A0306; TIGR00909
240015009064	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
240015009065	Ferritin-like domain; Region: Ferritin; pfam00210
240015009066	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
240015009067	dinuclear metal binding motif [ion binding]; other site
240015009068	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
240015009069	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
240015009070	Domain of unknown function (DUF329); Region: DUF329; pfam03884
240015009071	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
240015009072	tetramer interfaces [polypeptide binding]; other site
240015009073	binuclear metal-binding site [ion binding]; other site
240015009074	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
240015009075	competence damage-inducible protein A; Provisional; Region: PRK00549
240015009076	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
240015009077	putative MPT binding site; other site
240015009078	Competence-damaged protein; Region: CinA; pfam02464
240015009079	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
240015009080	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
240015009081	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
240015009082	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
240015009083	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
240015009084	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
240015009085	Zn2+ binding site [ion binding]; other site
240015009086	Mg2+ binding site [ion binding]; other site
240015009087	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
240015009088	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
240015009089	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
240015009090	P loop; other site
240015009091	GTP binding site [chemical binding]; other site
240015009092	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
240015009093	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
240015009094	catalytic motif [active]
240015009095	Zn binding site [ion binding]; other site
240015009096	RibD C-terminal domain; Region: RibD_C; cl17279
240015009097	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
240015009098	Lumazine binding domain; Region: Lum_binding; pfam00677
240015009099	Lumazine binding domain; Region: Lum_binding; pfam00677
240015009100	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
240015009101	catalytic residue [active]
240015009102	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
240015009103	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
240015009104	DNA protecting protein DprA; Region: dprA; TIGR00732
240015009105	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
240015009106	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
240015009107	active site
240015009108	interdomain interaction site; other site
240015009109	putative metal-binding site [ion binding]; other site
240015009110	nucleotide binding site [chemical binding]; other site
240015009111	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
240015009112	domain I; other site
240015009113	DNA binding groove [nucleotide binding]
240015009114	phosphate binding site [ion binding]; other site
240015009115	domain II; other site
240015009116	domain III; other site
240015009117	nucleotide binding site [chemical binding]; other site
240015009118	catalytic site [active]
240015009119	domain IV; other site
240015009120	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
240015009121	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
240015009122	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
240015009123	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
240015009124	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
240015009125	Domain of unknown function (DUF427); Region: DUF427; pfam04248
240015009126	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
240015009127	GAF domain; Region: GAF; pfam01590
240015009128	GAF domain; Region: GAF_2; pfam13185
240015009129	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
240015009130	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
240015009131	metal binding site [ion binding]; metal-binding site
240015009132	active site
240015009133	I-site; other site
240015009134	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
240015009135	PIN domain; Region: PIN_3; cl17397
240015009136	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
240015009137	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
240015009138	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
240015009139	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
240015009140	Found in ATP-dependent protease La (LON); Region: LON; smart00464
240015009141	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015009142	Walker A motif; other site
240015009143	ATP binding site [chemical binding]; other site
240015009144	Walker B motif; other site
240015009145	arginine finger; other site
240015009146	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
240015009147	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
240015009148	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
240015009149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
240015009150	Walker A motif; other site
240015009151	ATP binding site [chemical binding]; other site
240015009152	Walker B motif; other site
240015009153	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
240015009154	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
240015009155	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
240015009156	oligomer interface [polypeptide binding]; other site
240015009157	active site residues [active]
240015009158	trigger factor; Region: tig; TIGR00115
240015009159	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
240015009160	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
240015009161	potassium/proton antiporter; Reviewed; Region: PRK05326
240015009162	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
240015009163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
240015009164	putative substrate translocation pore; other site
240015009165	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
240015009166	active site clefts [active]
240015009167	zinc binding site [ion binding]; other site
240015009168	dimer interface [polypeptide binding]; other site
240015009169	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
240015009170	Beta-lactamase; Region: Beta-lactamase; pfam00144
240015009171	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
240015009172	dimerization interface [polypeptide binding]; other site
240015009173	putative DNA binding site [nucleotide binding]; other site
240015009174	putative Zn2+ binding site [ion binding]; other site
240015009175	Low molecular weight phosphatase family; Region: LMWPc; cd00115
240015009176	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
240015009177	active site
240015009178	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
240015009179	arsenical-resistance protein; Region: acr3; TIGR00832
240015009180	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
240015009181	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
240015009182	CHAD domain; Region: CHAD; cl10506
240015009183	exopolyphosphatase; Region: exo_poly_only; TIGR03706
240015009184	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
240015009185	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
240015009186	catalytic core [active]
240015009187	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
240015009188	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
240015009189	catalytic residues [active]
240015009190	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
240015009191	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
240015009192	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
240015009193	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
240015009194	putative active site [active]
240015009195	catalytic site [active]
240015009196	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
240015009197	putative domain interface [polypeptide binding]; other site
240015009198	putative active site [active]
240015009199	catalytic site [active]
240015009200	Outer membrane efflux protein; Region: OEP; pfam02321
240015009201	Outer membrane efflux protein; Region: OEP; pfam02321
240015009202	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
240015009203	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
240015009204	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015009205	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
240015009206	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
240015009207	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
240015009208	active site residue [active]
240015009209	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
240015009210	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
240015009211	4Fe-4S binding domain; Region: Fer4; pfam00037
240015009212	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
240015009213	putative amphipathic alpha helix; other site
240015009214	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
240015009215	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
240015009216	putative acyl-acceptor binding pocket; other site
240015009217	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
240015009218	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
240015009219	trimer interface [polypeptide binding]; other site
240015009220	active site
240015009221	UDP-GlcNAc binding site [chemical binding]; other site
240015009222	lipid binding site [chemical binding]; lipid-binding site
240015009223	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
240015009224	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
240015009225	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
240015009226	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
240015009227	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
240015009228	ligand binding site [chemical binding]; other site
240015009229	flexible hinge region; other site
240015009230	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
240015009231	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
240015009232	ATP binding site [chemical binding]; other site
240015009233	Mg2+ binding site [ion binding]; other site
240015009234	G-X-G motif; other site
240015009235	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
240015009236	ketol-acid reductoisomerase; Provisional; Region: PRK05479
240015009237	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
240015009238	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
240015009239	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
240015009240	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
240015009241	putative valine binding site [chemical binding]; other site
240015009242	dimer interface [polypeptide binding]; other site
240015009243	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
240015009244	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
240015009245	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
240015009246	PYR/PP interface [polypeptide binding]; other site
240015009247	dimer interface [polypeptide binding]; other site
240015009248	TPP binding site [chemical binding]; other site
240015009249	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
240015009250	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
240015009251	TPP-binding site [chemical binding]; other site
240015009252	dimer interface [polypeptide binding]; other site
240015009253	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
240015009254	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
240015009255	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
240015009256	substrate binding site [chemical binding]; other site
240015009257	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
240015009258	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
240015009259	substrate binding site [chemical binding]; other site
240015009260	ligand binding site [chemical binding]; other site
240015009261	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
240015009262	tartrate dehydrogenase; Region: TTC; TIGR02089
240015009263	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
240015009264	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
240015009265	active site
240015009266	catalytic residues [active]
240015009267	metal binding site [ion binding]; metal-binding site
240015009268	Transcriptional regulator [Transcription]; Region: LysR; COG0583
240015009269	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
240015009270	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
240015009271	dimerization interface [polypeptide binding]; other site
240015009272	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
240015009273	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
240015009274	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
240015009275	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
240015009276	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
240015009277	NAD binding site [chemical binding]; other site
240015009278	homodimer interface [polypeptide binding]; other site
240015009279	active site
240015009280	substrate binding site [chemical binding]; other site
240015009281	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
240015009282	putative ligand binding site [chemical binding]; other site
240015009283	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015009284	Walker A/P-loop; other site
240015009285	ATP binding site [chemical binding]; other site
240015009286	Q-loop/lid; other site
240015009287	ABC transporter signature motif; other site
240015009288	Walker B; other site
240015009289	D-loop; other site
240015009290	H-loop/switch region; other site
240015009291	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
240015009292	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
240015009293	substrate binding site [chemical binding]; other site
240015009294	dimer interface [polypeptide binding]; other site
240015009295	ATP binding site [chemical binding]; other site
240015009296	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
240015009297	intersubunit interface [polypeptide binding]; other site
240015009298	active site
240015009299	catalytic residue [active]
240015009300	Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111
240015009301	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
240015009302	NAD(P) binding site [chemical binding]; other site
240015009303	catalytic residues [active]
240015009304	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
240015009305	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
240015009306	NAD(P) binding site [chemical binding]; other site
240015009307	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
240015009308	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
240015009309	active site
240015009310	PHP Thumb interface [polypeptide binding]; other site
240015009311	metal binding site [ion binding]; metal-binding site
240015009312	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
240015009313	generic binding surface I; other site
240015009314	generic binding surface II; other site
240015009315	Uncharacterized conserved protein [Function unknown]; Region: COG2353
240015009316	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
240015009317	Zn binding site [ion binding]; other site
240015009318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015009319	TPR motif; other site
240015009320	binding surface
240015009321	TPR repeat; Region: TPR_11; pfam13414
240015009322	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
240015009323	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
240015009324	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
240015009325	active site
240015009326	catalytic residues [active]
240015009327	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
240015009328	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
240015009329	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
240015009330	Walker A/P-loop; other site
240015009331	ATP binding site [chemical binding]; other site
240015009332	Q-loop/lid; other site
240015009333	ABC transporter signature motif; other site
240015009334	Walker B; other site
240015009335	D-loop; other site
240015009336	H-loop/switch region; other site
240015009337	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
240015009338	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
240015009339	FeS/SAM binding site; other site
240015009340	HemN C-terminal domain; Region: HemN_C; pfam06969
240015009341	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
240015009342	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
240015009343	NAD binding site [chemical binding]; other site
240015009344	substrate binding site [chemical binding]; other site
240015009345	catalytic Zn binding site [ion binding]; other site
240015009346	tetramer interface [polypeptide binding]; other site
240015009347	structural Zn binding site [ion binding]; other site
240015009348	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
240015009349	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
240015009350	HlyD family secretion protein; Region: HlyD_3; pfam13437
240015009351	YtkA-like; Region: YtkA; pfam13115
240015009352	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
240015009353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
240015009354	Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971
240015009355	Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089
240015009356	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972
240015009357	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015009358	DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033
240015009359	DNA binding site [nucleotide binding]
240015009360	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
240015009361	Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666
240015009362	DNA binding site [nucleotide binding]
240015009363	heterodimer interface [polypeptide binding]; other site
240015009364	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
240015009365	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
240015009366	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
240015009367	active site
240015009368	DNA binding site [nucleotide binding]
240015009369	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
240015009370	DNA binding site [nucleotide binding]
240015009371	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
240015009372	nucleotide binding site [chemical binding]; other site
240015009373	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
240015009374	Beta-lactamase; Region: Beta-lactamase; pfam00144
240015009375	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
240015009376	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015009377	FtsX-like permease family; Region: FtsX; pfam02687
240015009378	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
240015009379	FtsX-like permease family; Region: FtsX; pfam02687
240015009380	Predicted transcriptional regulators [Transcription]; Region: COG1695
240015009381	transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433
240015009382	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
240015009383	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
240015009384	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
240015009385	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
240015009386	DNA-binding site [nucleotide binding]; DNA binding site
240015009387	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
240015009388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015009389	homodimer interface [polypeptide binding]; other site
240015009390	catalytic residue [active]
240015009391	Amino acid permease; Region: AA_permease_2; pfam13520
240015009392	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
240015009393	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015009394	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
240015009395	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
240015009396	N-terminal plug; other site
240015009397	ligand-binding site [chemical binding]; other site
240015009398	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
240015009399	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
240015009400	active site
240015009401	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
240015009402	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
240015009403	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
240015009404	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
240015009405	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
240015009406	Putative zinc-finger; Region: zf-HC2; pfam13490
240015009407	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
240015009408	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
240015009409	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
240015009410	DNA binding residues [nucleotide binding]
240015009411	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
240015009412	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
240015009413	inhibitor-cofactor binding pocket; inhibition site
240015009414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
240015009415	catalytic residue [active]
240015009416	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
240015009417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
240015009418	active site
240015009419	phosphorylation site [posttranslational modification]
240015009420	intermolecular recognition site; other site
240015009421	dimerization interface [polypeptide binding]; other site
240015009422	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
240015009423	DNA binding residues [nucleotide binding]
240015009424	dimerization interface [polypeptide binding]; other site
240015009425	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
240015009426	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
240015009427	Histidine kinase; Region: HisKA_3; pfam07730
240015009428	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
240015009429	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
240015009430	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
240015009431	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
240015009432	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
240015009433	TPR motif; other site
240015009434	binding surface
240015009435	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015009436	binding surface
240015009437	TPR motif; other site
240015009438	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
240015009439	TPR motif; other site
240015009440	binding surface
240015009441	hypothetical protein; Provisional; Region: PRK08201
240015009442	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
240015009443	metal binding site [ion binding]; metal-binding site
240015009444	putative dimer interface [polypeptide binding]; other site
240015009445	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
240015009446	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
240015009447	RES domain; Region: RES; cl02411
240015009448	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
240015009449	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
240015009450	GTP binding site; other site
240015009451	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
240015009452	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
240015009453	Walker A/P-loop; other site
240015009454	ATP binding site [chemical binding]; other site
240015009455	Q-loop/lid; other site
240015009456	ABC transporter signature motif; other site
240015009457	Walker B; other site
240015009458	D-loop; other site
240015009459	H-loop/switch region; other site
240015009460	Lipocalin-like domain; Region: Lipocalin_5; pfam13924