-- dump date   	20140618_184717
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
525909000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
525909000002	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
525909000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909000004	Walker A motif; other site
525909000005	ATP binding site [chemical binding]; other site
525909000006	Walker B motif; other site
525909000007	arginine finger; other site
525909000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
525909000009	DnaA box-binding interface [nucleotide binding]; other site
525909000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
525909000011	putative DNA binding surface [nucleotide binding]; other site
525909000012	dimer interface [polypeptide binding]; other site
525909000013	beta-clamp/clamp loader binding surface; other site
525909000014	beta-clamp/translesion DNA polymerase binding surface; other site
525909000015	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909000016	Walker A/P-loop; other site
525909000017	ATP binding site [chemical binding]; other site
525909000018	Q-loop/lid; other site
525909000019	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
525909000020	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
525909000021	Mg2+ binding site [ion binding]; other site
525909000022	G-X-G motif; other site
525909000023	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
525909000024	anchoring element; other site
525909000025	dimer interface [polypeptide binding]; other site
525909000026	ATP binding site [chemical binding]; other site
525909000027	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
525909000028	active site
525909000029	putative metal-binding site [ion binding]; other site
525909000030	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
525909000031	DNA gyrase subunit A; Validated; Region: PRK05560
525909000032	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
525909000033	CAP-like domain; other site
525909000034	active site
525909000035	primary dimer interface [polypeptide binding]; other site
525909000036	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
525909000037	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
525909000038	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
525909000039	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
525909000040	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
525909000041	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
525909000042	Walker A motif; other site
525909000043	ATP binding site [chemical binding]; other site
525909000044	Walker B motif; other site
525909000045	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
525909000046	active site
525909000047	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
525909000048	aromatic chitin/cellulose binding site residues [chemical binding]; other site
525909000049	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
525909000050	aromatic chitin/cellulose binding site residues [chemical binding]; other site
525909000051	potential frameshift: common BLAST hit: gi|251794552|ref|YP_003009283.1| Glycosyltransferase-like protein probably involved in cell wall
525909000052	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
525909000053	active site
525909000054	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
525909000055	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
525909000056	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
525909000057	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
525909000058	active site
525909000059	NTP binding site [chemical binding]; other site
525909000060	metal binding triad [ion binding]; metal-binding site
525909000061	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
525909000062	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
525909000063	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
525909000064	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
525909000065	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
525909000066	active site
525909000067	Zn binding site [ion binding]; other site
525909000068	putative acetyltransferase; Provisional; Region: PRK03624
525909000069	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
525909000070	Coenzyme A binding pocket [chemical binding]; other site
525909000071	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
525909000072	EDD domain protein, DegV family; Region: DegV; TIGR00762
525909000073	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
525909000074	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
525909000075	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
525909000076	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909000077	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
525909000078	catalytic residues [active]
525909000079	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
525909000080	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
525909000081	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
525909000082	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713
525909000083	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
525909000084	non-specific DNA binding site [nucleotide binding]; other site
525909000085	salt bridge; other site
525909000086	sequence-specific DNA binding site [nucleotide binding]; other site
525909000087	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
525909000088	active site
525909000089	NTP binding site [chemical binding]; other site
525909000090	metal binding triad [ion binding]; metal-binding site
525909000091	antibiotic binding site [chemical binding]; other site
525909000092	Protein of unknown function DUF86; Region: DUF86; cl01031
525909000093	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
525909000094	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
525909000095	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
525909000096	Predicted transcriptional regulators [Transcription]; Region: COG1695
525909000097	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
525909000098	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
525909000099	active site
525909000100	oligomerization interface [polypeptide binding]; other site
525909000101	metal binding site [ion binding]; metal-binding site
525909000102	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
525909000103	phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600
525909000104	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
525909000105	Walker A motif; other site
525909000106	ATP binding site [chemical binding]; other site
525909000107	Walker B motif; other site
525909000108	DNA binding loops [nucleotide binding]
525909000109	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
525909000110	protein-splicing catalytic site; other site
525909000111	thioester formation/cholesterol transfer; other site
525909000112	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
525909000113	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
525909000114	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
525909000115	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
525909000116	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
525909000117	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
525909000118	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
525909000119	dimer interface [polypeptide binding]; other site
525909000120	ssDNA binding site [nucleotide binding]; other site
525909000121	tetramer (dimer of dimers) interface [polypeptide binding]; other site
525909000122	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
525909000123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315
525909000124	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
525909000125	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
525909000126	Cysteine-rich domain; Region: CCG; pfam02754
525909000127	Cysteine-rich domain; Region: CCG; pfam02754
525909000128	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
525909000129	trimer interface [polypeptide binding]; other site
525909000130	active site
525909000131	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
525909000132	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
525909000133	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
525909000134	UTRA domain; Region: UTRA; cl17743
525909000135	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
525909000136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909000137	Transposase; Region: HTH_Tnp_1; cl17663
525909000138	putative transposase OrfB; Reviewed; Region: PHA02517
525909000139	HTH-like domain; Region: HTH_21; pfam13276
525909000140	Integrase core domain; Region: rve; pfam00665
525909000141	Integrase core domain; Region: rve_3; pfam13683
525909000142	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
525909000143	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
525909000144	active site
525909000145	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
525909000146	AAA ATPase domain; Region: AAA_16; pfam13191
525909000147	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
525909000148	active site
525909000149	catalytic site [active]
525909000150	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
525909000151	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
525909000152	active site
525909000153	nucleophile elbow; other site
525909000154	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909000155	dimerization interface [polypeptide binding]; other site
525909000156	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
525909000157	putative Zn2+ binding site [ion binding]; other site
525909000158	putative DNA binding site [nucleotide binding]; other site
525909000159	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
525909000160	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909000161	catalytic residue [active]
525909000162	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
525909000163	nucleotide binding site/active site [active]
525909000164	HIT family signature motif; other site
525909000165	catalytic residue [active]
525909000166	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
525909000167	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
525909000168	CoA binding domain; Region: CoA_binding; cl17356
525909000169	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
525909000170	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166
525909000171	putative ligand binding site [chemical binding]; other site
525909000172	putative NAD binding site [chemical binding]; other site
525909000173	catalytic site [active]
525909000174	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
525909000175	peptidase domain interface [polypeptide binding]; other site
525909000176	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
525909000177	active site
525909000178	catalytic triad [active]
525909000179	calcium binding site [ion binding]; other site
525909000180	histidyl-tRNA synthetase; Region: hisS; TIGR00442
525909000181	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
525909000182	dimer interface [polypeptide binding]; other site
525909000183	motif 1; other site
525909000184	active site
525909000185	motif 2; other site
525909000186	motif 3; other site
525909000187	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
525909000188	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
525909000189	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
525909000190	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
525909000191	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
525909000192	active site
525909000193	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
525909000194	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
525909000195	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
525909000196	dimer interface [polypeptide binding]; other site
525909000197	active site
525909000198	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
525909000199	Glutamine amidotransferase class-I; Region: GATase; pfam00117
525909000200	glutamine binding [chemical binding]; other site
525909000201	catalytic triad [active]
525909000202	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
525909000203	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
525909000204	active site
525909000205	ATP binding site [chemical binding]; other site
525909000206	substrate binding site [chemical binding]; other site
525909000207	activation loop (A-loop); other site
525909000208	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
525909000209	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
525909000210	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
525909000211	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
525909000212	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
525909000213	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
525909000214	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
525909000215	active site
525909000216	ATP binding site [chemical binding]; other site
525909000217	substrate binding site [chemical binding]; other site
525909000218	activation loop (A-loop); other site
525909000219	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
525909000220	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
525909000221	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
525909000222	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
525909000223	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
525909000224	active site
525909000225	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
525909000226	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
525909000227	phosphopeptide binding site; other site
525909000228	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
525909000229	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
525909000230	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
525909000231	phosphopeptide binding site; other site
525909000232	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
525909000233	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
525909000234	NAD(P) binding site [chemical binding]; other site
525909000235	catalytic residues [active]
525909000236	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
525909000237	active site 2 [active]
525909000238	active site 1 [active]
525909000239	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
525909000240	Prephenate dehydratase; Region: PDT; pfam00800
525909000241	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
525909000242	putative L-Phe binding site [chemical binding]; other site
525909000243	AIR carboxylase; Region: AIRC; smart01001
525909000244	Protein of unknown function DUF111; Region: DUF111; cl03398
525909000245	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
525909000246	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
525909000247	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
525909000248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909000249	Walker A motif; other site
525909000250	ATP binding site [chemical binding]; other site
525909000251	Walker B motif; other site
525909000252	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
525909000253	recombination protein RecR; Reviewed; Region: recR; PRK00076
525909000254	RecR protein; Region: RecR; pfam02132
525909000255	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
525909000256	putative active site [active]
525909000257	putative metal-binding site [ion binding]; other site
525909000258	tetramer interface [polypeptide binding]; other site
525909000259	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
525909000260	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
525909000261	dimer interface [polypeptide binding]; other site
525909000262	substrate binding site [chemical binding]; other site
525909000263	metal binding site [ion binding]; metal-binding site
525909000264	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
525909000265	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
525909000266	NAD(P) binding site [chemical binding]; other site
525909000267	putative acyltransferase; Provisional; Region: PRK05790
525909000268	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
525909000269	dimer interface [polypeptide binding]; other site
525909000270	active site
525909000271	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
525909000272	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
525909000273	Methyltransferase domain; Region: Methyltransf_23; pfam13489
525909000274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909000275	S-adenosylmethionine binding site [chemical binding]; other site
525909000276	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
525909000277	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
525909000278	active site
525909000279	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
525909000280	active site
525909000281	aspartate kinase; Reviewed; Region: PRK06635
525909000282	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
525909000283	putative nucleotide binding site [chemical binding]; other site
525909000284	putative catalytic residues [active]
525909000285	putative Mg ion binding site [ion binding]; other site
525909000286	putative aspartate binding site [chemical binding]; other site
525909000287	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
525909000288	putative allosteric regulatory site; other site
525909000289	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
525909000290	putative allosteric regulatory residue; other site
525909000291	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
525909000292	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
525909000293	flagellin; Provisional; Region: PRK12804
525909000294	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
525909000295	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
525909000296	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
525909000297	Flagellar protein FliS; Region: FliS; cl00654
525909000298	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
525909000299	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
525909000300	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
525909000301	dimer interface [polypeptide binding]; other site
525909000302	catalytic residue [active]
525909000303	metal binding site [ion binding]; metal-binding site
525909000304	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
525909000305	multimerization interface [polypeptide binding]; other site
525909000306	Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288
525909000307	Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; pfam08936
525909000308	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
525909000309	Hexamer/Pentamer interface [polypeptide binding]; other site
525909000310	central pore; other site
525909000311	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
525909000312	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
525909000313	Hexamer interface [polypeptide binding]; other site
525909000314	Hexagonal pore residue; other site
525909000315	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
525909000316	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
525909000317	Hexamer interface [polypeptide binding]; other site
525909000318	Hexagonal pore residue; other site
525909000319	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
525909000320	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
525909000321	Hexamer interface [polypeptide binding]; other site
525909000322	Hexagonal pore residue; other site
525909000323	Ferritin-like domain; Region: Ferritin; pfam00210
525909000324	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
525909000325	dinuclear metal binding motif [ion binding]; other site
525909000326	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
525909000327	AAA domain; Region: AAA_31; pfam13614
525909000328	P-loop; other site
525909000329	Magnesium ion binding site [ion binding]; other site
525909000330	MoxR-like ATPases [General function prediction only]; Region: COG0714
525909000331	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
525909000332	Walker A motif; other site
525909000333	ATP binding site [chemical binding]; other site
525909000334	Walker B motif; other site
525909000335	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
525909000336	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
525909000337	metal ion-dependent adhesion site (MIDAS); other site
525909000338	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
525909000339	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
525909000340	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
525909000341	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
525909000342	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
525909000343	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
525909000344	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
525909000345	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
525909000346	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
525909000347	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
525909000348	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
525909000349	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
525909000350	MgtE intracellular N domain; Region: MgtE_N; cl15244
525909000351	FliG C-terminal domain; Region: FliG_C; pfam01706
525909000352	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
525909000353	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
525909000354	Walker A motif; other site
525909000355	ATP binding site [chemical binding]; other site
525909000356	Walker B motif; other site
525909000357	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
525909000358	NlpC/P60 family; Region: NLPC_P60; pfam00877
525909000359	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
525909000360	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
525909000361	N-acetyl-D-glucosamine binding site [chemical binding]; other site
525909000362	catalytic residue [active]
525909000363	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
525909000364	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
525909000365	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
525909000366	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
525909000367	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
525909000368	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
525909000369	Flagellar protein (FlbD); Region: FlbD; pfam06289
525909000370	flagellar motor protein MotA; Validated; Region: PRK08124
525909000371	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
525909000372	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
525909000373	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
525909000374	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
525909000375	ligand binding site [chemical binding]; other site
525909000376	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
525909000377	Flagellar motor switch protein FliM; Region: FliM; pfam02154
525909000378	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
525909000379	flagellar motor switch protein FliN; Region: fliN; TIGR02480
525909000380	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
525909000381	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909000382	Transposase; Region: HTH_Tnp_1; cl17663
525909000383	putative transposase OrfB; Reviewed; Region: PHA02517
525909000384	HTH-like domain; Region: HTH_21; pfam13276
525909000385	Integrase core domain; Region: rve; pfam00665
525909000386	Integrase core domain; Region: rve_3; pfam13683
525909000387	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
525909000388	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
525909000389	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
525909000390	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
525909000391	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
525909000392	FHIPEP family; Region: FHIPEP; pfam00771
525909000393	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
525909000394	active site residue [active]
525909000395	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
525909000396	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
525909000397	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
525909000398	FeS/SAM binding site; other site
525909000399	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
525909000400	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
525909000401	substrate binding site [chemical binding]; other site
525909000402	hexamer interface [polypeptide binding]; other site
525909000403	metal binding site [ion binding]; metal-binding site
525909000404	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
525909000405	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
525909000406	TPP-binding site [chemical binding]; other site
525909000407	dimer interface [polypeptide binding]; other site
525909000408	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
525909000409	PYR/PP interface [polypeptide binding]; other site
525909000410	dimer interface [polypeptide binding]; other site
525909000411	TPP binding site [chemical binding]; other site
525909000412	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
525909000413	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
525909000414	active site
525909000415	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
525909000416	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
525909000417	active site
525909000418	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
525909000419	MgtC family; Region: MgtC; pfam02308
525909000420	Transcriptional regulators [Transcription]; Region: PurR; COG1609
525909000421	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
525909000422	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
525909000423	ligand binding site [chemical binding]; other site
525909000424	dimerization interface [polypeptide binding]; other site
525909000425	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
525909000426	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
525909000427	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
525909000428	substrate binding site [chemical binding]; other site
525909000429	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
525909000430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
525909000431	dimer interface [polypeptide binding]; other site
525909000432	conserved gate region; other site
525909000433	putative PBP binding loops; other site
525909000434	ABC-ATPase subunit interface; other site
525909000435	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
525909000436	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
525909000437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
525909000438	dimer interface [polypeptide binding]; other site
525909000439	conserved gate region; other site
525909000440	ABC-ATPase subunit interface; other site
525909000441	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
525909000442	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
525909000443	Walker A/P-loop; other site
525909000444	ATP binding site [chemical binding]; other site
525909000445	Q-loop/lid; other site
525909000446	ABC transporter signature motif; other site
525909000447	Walker B; other site
525909000448	D-loop; other site
525909000449	H-loop/switch region; other site
525909000450	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
525909000451	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
525909000452	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
525909000453	Walker A/P-loop; other site
525909000454	ATP binding site [chemical binding]; other site
525909000455	Q-loop/lid; other site
525909000456	ABC transporter signature motif; other site
525909000457	Walker B; other site
525909000458	D-loop; other site
525909000459	H-loop/switch region; other site
525909000460	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
525909000461	transcriptional regulator, ArgP family; Region: argP; TIGR03298
525909000462	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
525909000463	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
525909000464	dimerization interface [polypeptide binding]; other site
525909000465	Class I aldolases; Region: Aldolase_Class_I; cl17187
525909000466	catalytic residue [active]
525909000467	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
525909000468	MoaE interaction surface [polypeptide binding]; other site
525909000469	MoeB interaction surface [polypeptide binding]; other site
525909000470	thiocarboxylated glycine; other site
525909000471	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
525909000472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909000473	active site
525909000474	phosphorylation site [posttranslational modification]
525909000475	intermolecular recognition site; other site
525909000476	dimerization interface [polypeptide binding]; other site
525909000477	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
525909000478	DNA binding residues [nucleotide binding]
525909000479	dimerization interface [polypeptide binding]; other site
525909000480	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
525909000481	GAF domain; Region: GAF; pfam01590
525909000482	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
525909000483	Histidine kinase; Region: HisKA_3; pfam07730
525909000484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
525909000485	ATP binding site [chemical binding]; other site
525909000486	Mg2+ binding site [ion binding]; other site
525909000487	G-X-G motif; other site
525909000488	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
525909000489	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909000490	metal binding site [ion binding]; metal-binding site
525909000491	active site
525909000492	I-site; other site
525909000493	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
525909000494	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
525909000495	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
525909000496	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
525909000497	Iron-sulfur protein interface; other site
525909000498	proximal heme binding site [chemical binding]; other site
525909000499	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
525909000500	Iron-sulfur protein interface; other site
525909000501	proximal heme binding site [chemical binding]; other site
525909000502	seryl-tRNA synthetase; Provisional; Region: PRK05431
525909000503	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
525909000504	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
525909000505	dimer interface [polypeptide binding]; other site
525909000506	active site
525909000507	motif 1; other site
525909000508	motif 2; other site
525909000509	motif 3; other site
525909000510	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
525909000511	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
525909000512	Walker A/P-loop; other site
525909000513	ATP binding site [chemical binding]; other site
525909000514	Q-loop/lid; other site
525909000515	ABC transporter signature motif; other site
525909000516	Walker B; other site
525909000517	D-loop; other site
525909000518	H-loop/switch region; other site
525909000519	ABC-2 type transporter; Region: ABC2_membrane; cl17235
525909000520	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
525909000521	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
525909000522	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
525909000523	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
525909000524	peptidase domain interface [polypeptide binding]; other site
525909000525	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
525909000526	active site
525909000527	catalytic triad [active]
525909000528	calcium binding site [ion binding]; other site
525909000529	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
525909000530	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
525909000531	NADP binding site [chemical binding]; other site
525909000532	dimer interface [polypeptide binding]; other site
525909000533	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
525909000534	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
525909000535	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
525909000536	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
525909000537	metal binding site 2 [ion binding]; metal-binding site
525909000538	putative DNA binding helix; other site
525909000539	metal binding site 1 [ion binding]; metal-binding site
525909000540	dimer interface [polypeptide binding]; other site
525909000541	structural Zn2+ binding site [ion binding]; other site
525909000542	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
525909000543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909000544	active site
525909000545	phosphorylation site [posttranslational modification]
525909000546	intermolecular recognition site; other site
525909000547	dimerization interface [polypeptide binding]; other site
525909000548	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
525909000549	DNA binding site [nucleotide binding]
525909000550	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
525909000551	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
525909000552	dimer interface [polypeptide binding]; other site
525909000553	phosphorylation site [posttranslational modification]
525909000554	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
525909000555	ATP binding site [chemical binding]; other site
525909000556	Mg2+ binding site [ion binding]; other site
525909000557	G-X-G motif; other site
525909000558	AAA-like domain; Region: AAA_10; pfam12846
525909000559	Domain of unknown function DUF87; Region: DUF87; pfam01935
525909000560	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
525909000561	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
525909000562	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
525909000563	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
525909000564	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
525909000565	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
525909000566	FliW protein; Region: FliW; pfam02623
525909000567	Global regulator protein family; Region: CsrA; pfam02599
525909000568	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
525909000569	putative binding surface; other site
525909000570	active site
525909000571	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
525909000572	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
525909000573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
525909000574	ATP binding site [chemical binding]; other site
525909000575	Mg2+ binding site [ion binding]; other site
525909000576	G-X-G motif; other site
525909000577	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
525909000578	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
525909000579	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
525909000580	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
525909000581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909000582	active site
525909000583	phosphorylation site [posttranslational modification]
525909000584	intermolecular recognition site; other site
525909000585	dimerization interface [polypeptide binding]; other site
525909000586	CheB methylesterase; Region: CheB_methylest; pfam01339
525909000587	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
525909000588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909000589	Transcriptional regulators [Transcription]; Region: GntR; COG1802
525909000590	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
525909000591	DNA-binding site [nucleotide binding]; DNA binding site
525909000592	FCD domain; Region: FCD; pfam07729
525909000593	Response regulator receiver domain; Region: Response_reg; pfam00072
525909000594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909000595	active site
525909000596	phosphorylation site [posttranslational modification]
525909000597	intermolecular recognition site; other site
525909000598	dimerization interface [polypeptide binding]; other site
525909000599	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
525909000600	putative metal binding site; other site
525909000601	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
525909000602	catalytic triad [active]
525909000603	active site nucleophile [active]
525909000604	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
525909000605	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
525909000606	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
525909000607	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
525909000608	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
525909000609	B12 binding site [chemical binding]; other site
525909000610	cobalt ligand [ion binding]; other site
525909000611	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
525909000612	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909000613	metal binding site [ion binding]; metal-binding site
525909000614	active site
525909000615	I-site; other site
525909000616	shikimate kinase; Reviewed; Region: aroK; PRK00131
525909000617	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
525909000618	ADP binding site [chemical binding]; other site
525909000619	magnesium binding site [ion binding]; other site
525909000620	putative shikimate binding site; other site
525909000621	Vitamin K epoxide reductase family in archaea and some bacteria; Region: VKOR_arc; cd12918
525909000622	putative active site [active]
525909000623	redox center [active]
525909000624	Domain of unknown function (DUF929); Region: DUF929; pfam06053
525909000625	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
525909000626	putative active site [active]
525909000627	homotrimer interaction site [polypeptide binding]; other site
525909000628	BioY family; Region: BioY; pfam02632
525909000629	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
525909000630	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
525909000631	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
525909000632	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
525909000633	Amidase; Region: Amidase; cl11426
525909000634	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
525909000635	hypothetical protein; Provisional; Region: PRK07907
525909000636	metal binding site [ion binding]; metal-binding site
525909000637	putative dimer interface [polypeptide binding]; other site
525909000638	Domain of unknown function DUF59; Region: DUF59; pfam01883
525909000639	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
525909000640	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
525909000641	Walker A motif; other site
525909000642	Response regulator receiver domain; Region: Response_reg; pfam00072
525909000643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909000644	active site
525909000645	phosphorylation site [posttranslational modification]
525909000646	intermolecular recognition site; other site
525909000647	dimerization interface [polypeptide binding]; other site
525909000648	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
525909000649	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
525909000650	DTAP/Switch II; other site
525909000651	Switch I; other site
525909000652	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
525909000653	DTAP/Switch II; other site
525909000654	Switch I; other site
525909000655	Transcription factor WhiB; Region: Whib; pfam02467
525909000656	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
525909000657	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
525909000658	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
525909000659	DNA binding site [nucleotide binding]
525909000660	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
525909000661	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
525909000662	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
525909000663	glutamine synthetase, type I; Region: GlnA; TIGR00653
525909000664	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
525909000665	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
525909000666	LabA_like proteins; Region: LabA_like; cd06167
525909000667	putative metal binding site [ion binding]; other site
525909000668	Peptidase family M23; Region: Peptidase_M23; pfam01551
525909000669	NAD synthetase; Provisional; Region: PRK13981
525909000670	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
525909000671	multimer interface [polypeptide binding]; other site
525909000672	active site
525909000673	catalytic triad [active]
525909000674	protein interface 1 [polypeptide binding]; other site
525909000675	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
525909000676	homodimer interface [polypeptide binding]; other site
525909000677	NAD binding pocket [chemical binding]; other site
525909000678	ATP binding pocket [chemical binding]; other site
525909000679	Mg binding site [ion binding]; other site
525909000680	active-site loop [active]
525909000681	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
525909000682	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
525909000683	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
525909000684	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
525909000685	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
525909000686	DNA binding residues [nucleotide binding]
525909000687	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
525909000688	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
525909000689	NAD(P) binding pocket [chemical binding]; other site
525909000690	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
525909000691	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
525909000692	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
525909000693	domain interfaces; other site
525909000694	active site
525909000695	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
525909000696	active site
525909000697	SAM binding site [chemical binding]; other site
525909000698	homodimer interface [polypeptide binding]; other site
525909000699	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
525909000700	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
525909000701	active site
525909000702	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
525909000703	dimer interface [polypeptide binding]; other site
525909000704	active site
525909000705	Schiff base residues; other site
525909000706	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
525909000707	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
525909000708	inhibitor-cofactor binding pocket; inhibition site
525909000709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909000710	catalytic residue [active]
525909000711	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
525909000712	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
525909000713	putative ion selectivity filter; other site
525909000714	putative pore gating glutamate residue; other site
525909000715	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
525909000716	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
525909000717	substrate binding site [chemical binding]; other site
525909000718	oxyanion hole (OAH) forming residues; other site
525909000719	trimer interface [polypeptide binding]; other site
525909000720	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
525909000721	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
525909000722	putative active site [active]
525909000723	putative metal binding site [ion binding]; other site
525909000724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909000725	active site
525909000726	conserved hypothetical protein; Region: TIGR03843
525909000727	Protein of unknown function (DUF3090); Region: DUF3090; cl12832
525909000728	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
525909000729	catalytic core [active]
525909000730	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
525909000731	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
525909000732	dimer interface [polypeptide binding]; other site
525909000733	active site
525909000734	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
525909000735	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
525909000736	catalytic triad [active]
525909000737	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
525909000738	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
525909000739	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
525909000740	catalytic Zn binding site [ion binding]; other site
525909000741	NAD(P) binding site [chemical binding]; other site
525909000742	structural Zn binding site [ion binding]; other site
525909000743	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
525909000744	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
525909000745	active site
525909000746	catalytic tetrad [active]
525909000747	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909000748	S-adenosylmethionine binding site [chemical binding]; other site
525909000749	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
525909000750	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
525909000751	dimer interface [polypeptide binding]; other site
525909000752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909000753	catalytic residue [active]
525909000754	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
525909000755	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
525909000756	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909000757	Walker A/P-loop; other site
525909000758	ATP binding site [chemical binding]; other site
525909000759	Q-loop/lid; other site
525909000760	ABC transporter signature motif; other site
525909000761	Walker B; other site
525909000762	D-loop; other site
525909000763	H-loop/switch region; other site
525909000764	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
525909000765	putative FMN binding site [chemical binding]; other site
525909000766	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
525909000767	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
525909000768	agmatinase; Region: agmatinase; TIGR01230
525909000769	oligomer interface [polypeptide binding]; other site
525909000770	putative active site [active]
525909000771	Mn binding site [ion binding]; other site
525909000772	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
525909000773	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
525909000774	non-specific DNA binding site [nucleotide binding]; other site
525909000775	salt bridge; other site
525909000776	sequence-specific DNA binding site [nucleotide binding]; other site
525909000777	Cupin domain; Region: Cupin_2; pfam07883
525909000778	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
525909000779	putative transposase OrfB; Reviewed; Region: PHA02517
525909000780	HTH-like domain; Region: HTH_21; pfam13276
525909000781	Integrase core domain; Region: rve; pfam00665
525909000782	Integrase core domain; Region: rve_3; pfam13683
525909000783	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909000784	Transposase; Region: HTH_Tnp_1; cl17663
525909000785	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
525909000786	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
525909000787	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825
525909000788	putative hydrophobic ligand binding site [chemical binding]; other site
525909000789	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
525909000790	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
525909000791	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
525909000792	active site
525909000793	DNA binding site [nucleotide binding]
525909000794	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
525909000795	DEAD-like helicases superfamily; Region: DEXDc; smart00487
525909000796	ATP binding site [chemical binding]; other site
525909000797	putative Mg++ binding site [ion binding]; other site
525909000798	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
525909000799	nucleotide binding region [chemical binding]; other site
525909000800	ATP-binding site [chemical binding]; other site
525909000801	Putative FMN-binding domain; Region: FMN_bind_2; cl17803
525909000802	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
525909000803	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
525909000804	substrate binding site [chemical binding]; other site
525909000805	oxyanion hole (OAH) forming residues; other site
525909000806	trimer interface [polypeptide binding]; other site
525909000807	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
525909000808	Ligand Binding Site [chemical binding]; other site
525909000809	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
525909000810	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
525909000811	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
525909000812	Soluble P-type ATPase [General function prediction only]; Region: COG4087
525909000813	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
525909000814	Ligand Binding Site [chemical binding]; other site
525909000815	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
525909000816	Ligand Binding Site [chemical binding]; other site
525909000817	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
525909000818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909000819	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
525909000820	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
525909000821	metal binding site 2 [ion binding]; metal-binding site
525909000822	putative DNA binding helix; other site
525909000823	metal binding site 1 [ion binding]; metal-binding site
525909000824	dimer interface [polypeptide binding]; other site
525909000825	structural Zn2+ binding site [ion binding]; other site
525909000826	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
525909000827	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
525909000828	dimer interface [polypeptide binding]; other site
525909000829	active site
525909000830	heme binding site [chemical binding]; other site
525909000831	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
525909000832	Uncharacterized conserved protein [Function unknown]; Region: COG0393
525909000833	Uncharacterized conserved protein [Function unknown]; Region: COG0393
525909000834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909000835	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
525909000836	NlpC/P60 family; Region: NLPC_P60; pfam00877
525909000837	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
525909000838	Domain of unknown function (DUF955); Region: DUF955; pfam06114
525909000839	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
525909000840	ABC-2 type transporter; Region: ABC2_membrane; cl17235
525909000841	putative transposase OrfB; Reviewed; Region: PHA02517
525909000842	HTH-like domain; Region: HTH_21; pfam13276
525909000843	Integrase core domain; Region: rve; pfam00665
525909000844	Integrase core domain; Region: rve_3; pfam13683
525909000845	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909000846	Transposase; Region: HTH_Tnp_1; cl17663
525909000847	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
525909000848	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
525909000849	active site
525909000850	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
525909000851	tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406
525909000852	active site
525909000853	HIGH motif; other site
525909000854	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
525909000855	KMSKS motif; other site
525909000856	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
525909000857	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
525909000858	active site
525909000859	HIGH motif; other site
525909000860	nucleotide binding site [chemical binding]; other site
525909000861	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
525909000862	active site
525909000863	KMSKS motif; other site
525909000864	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
525909000865	tRNA binding surface [nucleotide binding]; other site
525909000866	anticodon binding site; other site
525909000867	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
525909000868	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
525909000869	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909000870	dimerization interface [polypeptide binding]; other site
525909000871	putative DNA binding site [nucleotide binding]; other site
525909000872	putative Zn2+ binding site [ion binding]; other site
525909000873	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
525909000874	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
525909000875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
525909000876	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
525909000877	L-aspartate oxidase; Provisional; Region: PRK06175
525909000878	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
525909000879	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
525909000880	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
525909000881	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
525909000882	Transcription factor WhiB; Region: Whib; pfam02467
525909000883	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
525909000884	B12 binding site [chemical binding]; other site
525909000885	cobalt ligand [ion binding]; other site
525909000886	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
525909000887	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
525909000888	CoA-ligase; Region: Ligase_CoA; pfam00549
525909000889	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
525909000890	CoA binding domain; Region: CoA_binding; pfam02629
525909000891	CoA-ligase; Region: Ligase_CoA; pfam00549
525909000892	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
525909000893	active site
525909000894	substrate binding site [chemical binding]; other site
525909000895	cosubstrate binding site; other site
525909000896	catalytic site [active]
525909000897	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
525909000898	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
525909000899	purine monophosphate binding site [chemical binding]; other site
525909000900	dimer interface [polypeptide binding]; other site
525909000901	putative catalytic residues [active]
525909000902	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
525909000903	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
525909000904	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
525909000905	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
525909000906	homodimer interface [polypeptide binding]; other site
525909000907	NADP binding site [chemical binding]; other site
525909000908	substrate binding site [chemical binding]; other site
525909000909	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
525909000910	FAD binding site [chemical binding]; other site
525909000911	phosphate:H+ symporter; Region: 2A0109; TIGR00887
525909000912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909000913	putative substrate translocation pore; other site
525909000914	Transcription factor WhiB; Region: Whib; pfam02467
525909000915	glutamate formiminotransferase; Region: FtcD; TIGR02024
525909000916	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
525909000917	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
525909000918	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
525909000919	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
525909000920	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
525909000921	NADP-binding site; other site
525909000922	homotetramer interface [polypeptide binding]; other site
525909000923	substrate binding site [chemical binding]; other site
525909000924	homodimer interface [polypeptide binding]; other site
525909000925	active site
525909000926	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909000927	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
525909000928	Walker A/P-loop; other site
525909000929	ATP binding site [chemical binding]; other site
525909000930	Q-loop/lid; other site
525909000931	ABC transporter signature motif; other site
525909000932	Walker B; other site
525909000933	D-loop; other site
525909000934	H-loop/switch region; other site
525909000935	CcmB protein; Region: CcmB; cl17444
525909000936	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
525909000937	CcmE; Region: CcmE; cl00994
525909000938	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
525909000939	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
525909000940	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
525909000941	Cytochrome C biogenesis protein; Region: CcmH; cl01179
525909000942	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
525909000943	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
525909000944	Moco binding site; other site
525909000945	metal coordination site [ion binding]; other site
525909000946	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909000947	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
525909000948	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
525909000949	DNA binding residues [nucleotide binding]
525909000950	dimerization interface [polypeptide binding]; other site
525909000951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
525909000952	Mg2+ binding site [ion binding]; other site
525909000953	G-X-G motif; other site
525909000954	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
525909000955	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
525909000956	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
525909000957	Walker A/P-loop; other site
525909000958	ATP binding site [chemical binding]; other site
525909000959	Q-loop/lid; other site
525909000960	ABC transporter signature motif; other site
525909000961	Walker B; other site
525909000962	D-loop; other site
525909000963	H-loop/switch region; other site
525909000964	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909000965	putative DNA binding site [nucleotide binding]; other site
525909000966	dimerization interface [polypeptide binding]; other site
525909000967	Predicted transcriptional regulator [Transcription]; Region: COG2345
525909000968	putative Zn2+ binding site [ion binding]; other site
525909000969	Domain of unknown function DUF59; Region: DUF59; cl00941
525909000970	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
525909000971	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
525909000972	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
525909000973	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
525909000974	P loop; other site
525909000975	Nucleotide binding site [chemical binding]; other site
525909000976	DTAP/Switch II; other site
525909000977	Switch I; other site
525909000978	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
525909000979	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
525909000980	DTAP/Switch II; other site
525909000981	Switch I; other site
525909000982	histidinol-phosphatase; Provisional; Region: PRK07328
525909000983	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
525909000984	active site
525909000985	dimer interface [polypeptide binding]; other site
525909000986	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
525909000987	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
525909000988	Histidine kinase; Region: HisKA_2; pfam07568
525909000989	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
525909000990	ATP binding site [chemical binding]; other site
525909000991	Mg2+ binding site [ion binding]; other site
525909000992	G-X-G motif; other site
525909000993	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
525909000994	Ligand binding site [chemical binding]; other site
525909000995	Electron transfer flavoprotein domain; Region: ETF; pfam01012
525909000996	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
525909000997	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
525909000998	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
525909000999	Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055
525909001000	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
525909001001	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
525909001002	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
525909001003	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
525909001004	putative ADP-binding pocket [chemical binding]; other site
525909001005	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
525909001006	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
525909001007	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
525909001008	putative ADP-binding pocket [chemical binding]; other site
525909001009	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
525909001010	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
525909001011	NADH dehydrogenase subunit B; Validated; Region: PRK06411
525909001012	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
525909001013	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
525909001014	NADH dehydrogenase subunit D; Validated; Region: PRK06075
525909001015	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
525909001016	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
525909001017	putative dimer interface [polypeptide binding]; other site
525909001018	[2Fe-2S] cluster binding site [ion binding]; other site
525909001019	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
525909001020	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
525909001021	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
525909001022	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
525909001023	catalytic loop [active]
525909001024	iron binding site [ion binding]; other site
525909001025	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
525909001026	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
525909001027	molybdopterin cofactor binding site; other site
525909001028	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
525909001029	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
525909001030	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
525909001031	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
525909001032	4Fe-4S binding domain; Region: Fer4; pfam00037
525909001033	4Fe-4S binding domain; Region: Fer4; pfam00037
525909001034	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
525909001035	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
525909001036	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
525909001037	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
525909001038	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
525909001039	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
525909001040	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
525909001041	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
525909001042	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
525909001043	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
525909001044	classical (c) SDRs; Region: SDR_c; cd05233
525909001045	NAD(P) binding site [chemical binding]; other site
525909001046	active site
525909001047	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
525909001048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
525909001049	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
525909001050	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
525909001051	HhH-GPD superfamily base excision DNA repair protein; Region: HhH-GPD; pfam00730
525909001052	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
525909001053	helix-hairpin-helix signature motif; other site
525909001054	substrate binding pocket [chemical binding]; other site
525909001055	active site
525909001056	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
525909001057	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
525909001058	Coenzyme A binding pocket [chemical binding]; other site
525909001059	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
525909001060	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
525909001061	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
525909001062	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
525909001063	DNA binding residues [nucleotide binding]
525909001064	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
525909001065	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
525909001066	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
525909001067	putative homodimer interface [polypeptide binding]; other site
525909001068	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
525909001069	heterodimer interface [polypeptide binding]; other site
525909001070	homodimer interface [polypeptide binding]; other site
525909001071	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
525909001072	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
525909001073	L7/L12 interface [polypeptide binding]; other site
525909001074	23S rRNA interface [nucleotide binding]; other site
525909001075	L25 interface [polypeptide binding]; other site
525909001076	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
525909001077	mRNA/rRNA interface [nucleotide binding]; other site
525909001078	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
525909001079	23S rRNA interface [nucleotide binding]; other site
525909001080	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
525909001081	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
525909001082	core dimer interface [polypeptide binding]; other site
525909001083	peripheral dimer interface [polypeptide binding]; other site
525909001084	L10 interface [polypeptide binding]; other site
525909001085	L11 interface [polypeptide binding]; other site
525909001086	putative EF-Tu interaction site [polypeptide binding]; other site
525909001087	putative EF-G interaction site [polypeptide binding]; other site
525909001088	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
525909001089	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
525909001090	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
525909001091	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
525909001092	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
525909001093	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
525909001094	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
525909001095	RPB10 interaction site [polypeptide binding]; other site
525909001096	RPB1 interaction site [polypeptide binding]; other site
525909001097	RPB11 interaction site [polypeptide binding]; other site
525909001098	RPB3 interaction site [polypeptide binding]; other site
525909001099	RPB12 interaction site [polypeptide binding]; other site
525909001100	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
525909001101	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
525909001102	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
525909001103	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
525909001104	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
525909001105	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
525909001106	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
525909001107	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
525909001108	DNA binding site [nucleotide binding]
525909001109	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
525909001110	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
525909001111	S17 interaction site [polypeptide binding]; other site
525909001112	S8 interaction site; other site
525909001113	16S rRNA interaction site [nucleotide binding]; other site
525909001114	streptomycin interaction site [chemical binding]; other site
525909001115	23S rRNA interaction site [nucleotide binding]; other site
525909001116	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
525909001117	30S ribosomal protein S7; Validated; Region: PRK05302
525909001118	elongation factor G; Reviewed; Region: PRK00007
525909001119	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
525909001120	G1 box; other site
525909001121	putative GEF interaction site [polypeptide binding]; other site
525909001122	GTP/Mg2+ binding site [chemical binding]; other site
525909001123	Switch I region; other site
525909001124	G2 box; other site
525909001125	G3 box; other site
525909001126	Switch II region; other site
525909001127	G4 box; other site
525909001128	G5 box; other site
525909001129	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
525909001130	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
525909001131	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
525909001132	elongation factor Tu; Reviewed; Region: PRK00049
525909001133	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
525909001134	G1 box; other site
525909001135	GEF interaction site [polypeptide binding]; other site
525909001136	GTP/Mg2+ binding site [chemical binding]; other site
525909001137	Switch I region; other site
525909001138	G2 box; other site
525909001139	G3 box; other site
525909001140	Switch II region; other site
525909001141	G4 box; other site
525909001142	G5 box; other site
525909001143	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
525909001144	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
525909001145	Antibiotic Binding Site [chemical binding]; other site
525909001146	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
525909001147	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
525909001148	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
525909001149	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
525909001150	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
525909001151	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
525909001152	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
525909001153	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
525909001154	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
525909001155	putative translocon binding site; other site
525909001156	protein-rRNA interface [nucleotide binding]; other site
525909001157	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
525909001158	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
525909001159	G-X-X-G motif; other site
525909001160	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
525909001161	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
525909001162	23S rRNA interface [nucleotide binding]; other site
525909001163	5S rRNA interface [nucleotide binding]; other site
525909001164	putative antibiotic binding site [chemical binding]; other site
525909001165	L25 interface [polypeptide binding]; other site
525909001166	L27 interface [polypeptide binding]; other site
525909001167	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
525909001168	putative translocon interaction site; other site
525909001169	23S rRNA interface [nucleotide binding]; other site
525909001170	signal recognition particle (SRP54) interaction site; other site
525909001171	L23 interface [polypeptide binding]; other site
525909001172	trigger factor interaction site; other site
525909001173	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
525909001174	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
525909001175	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
525909001176	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
525909001177	RNA binding site [nucleotide binding]; other site
525909001178	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
525909001179	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
525909001180	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
525909001181	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
525909001182	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
525909001183	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
525909001184	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
525909001185	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
525909001186	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
525909001187	5S rRNA interface [nucleotide binding]; other site
525909001188	L5 interface [polypeptide binding]; other site
525909001189	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
525909001190	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
525909001191	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
525909001192	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
525909001193	23S rRNA binding site [nucleotide binding]; other site
525909001194	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
525909001195	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
525909001196	SecY translocase; Region: SecY; pfam00344
525909001197	adenylate kinase; Reviewed; Region: adk; PRK00279
525909001198	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
525909001199	AMP-binding site [chemical binding]; other site
525909001200	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
525909001201	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
525909001202	active site
525909001203	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
525909001204	rRNA binding site [nucleotide binding]; other site
525909001205	predicted 30S ribosome binding site; other site
525909001206	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
525909001207	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
525909001208	30S ribosomal protein S13; Region: bact_S13; TIGR03631
525909001209	30S ribosomal protein S11; Validated; Region: PRK05309
525909001210	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
525909001211	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
525909001212	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
525909001213	RNA binding surface [nucleotide binding]; other site
525909001214	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
525909001215	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
525909001216	alphaNTD - beta interaction site [polypeptide binding]; other site
525909001217	alphaNTD homodimer interface [polypeptide binding]; other site
525909001218	alphaNTD - beta' interaction site [polypeptide binding]; other site
525909001219	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
525909001220	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
525909001221	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
525909001222	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
525909001223	active site
525909001224	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
525909001225	23S rRNA interface [nucleotide binding]; other site
525909001226	L3 interface [polypeptide binding]; other site
525909001227	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
525909001228	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
525909001229	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
525909001230	active site
525909001231	substrate binding site [chemical binding]; other site
525909001232	metal binding site [ion binding]; metal-binding site
525909001233	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
525909001234	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
525909001235	active site
525909001236	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
525909001237	dimer interface [polypeptide binding]; other site
525909001238	active site
525909001239	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
525909001240	dimer interface [polypeptide binding]; other site
525909001241	active site
525909001242	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
525909001243	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318
525909001244	gating phenylalanine in ion channel; other site
525909001245	Transcriptional regulator [Transcription]; Region: LysR; COG0583
525909001246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
525909001247	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
525909001248	putative dimerization interface [polypeptide binding]; other site
525909001249	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
525909001250	Uncharacterized conserved protein [Function unknown]; Region: COG0062
525909001251	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
525909001252	putative substrate binding site [chemical binding]; other site
525909001253	putative ATP binding site [chemical binding]; other site
525909001254	alanine racemase; Reviewed; Region: alr; PRK00053
525909001255	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
525909001256	active site
525909001257	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
525909001258	substrate binding site [chemical binding]; other site
525909001259	dimer interface [polypeptide binding]; other site
525909001260	catalytic residues [active]
525909001261	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
525909001262	Fe-S cluster binding site [ion binding]; other site
525909001263	active site
525909001264	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
525909001265	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
525909001266	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
525909001267	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
525909001268	UGMP family protein; Validated; Region: PRK09604
525909001269	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
525909001270	oligomerisation interface [polypeptide binding]; other site
525909001271	mobile loop; other site
525909001272	roof hairpin; other site
525909001273	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
525909001274	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
525909001275	ring oligomerisation interface [polypeptide binding]; other site
525909001276	ATP/Mg binding site [chemical binding]; other site
525909001277	stacking interactions; other site
525909001278	hinge regions; other site
525909001279	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
525909001280	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909001281	Transposase; Region: HTH_Tnp_1; cl17663
525909001282	putative transposase OrfB; Reviewed; Region: PHA02517
525909001283	HTH-like domain; Region: HTH_21; pfam13276
525909001284	Integrase core domain; Region: rve; pfam00665
525909001285	Integrase core domain; Region: rve_3; pfam13683
525909001286	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
525909001287	Predicted integral membrane protein [Function unknown]; Region: COG5650
525909001288	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
525909001289	active site
525909001290	catalytic site [active]
525909001291	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
525909001292	putative active site [active]
525909001293	putative CoA binding site [chemical binding]; other site
525909001294	nudix motif; other site
525909001295	metal binding site [ion binding]; metal-binding site
525909001296	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
525909001297	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
525909001298	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
525909001299	CrcB-like protein; Region: CRCB; cl09114
525909001300	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
525909001301	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
525909001302	active site
525909001303	GMP synthase; Reviewed; Region: guaA; PRK00074
525909001304	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
525909001305	AMP/PPi binding site [chemical binding]; other site
525909001306	candidate oxyanion hole; other site
525909001307	catalytic triad [active]
525909001308	potential glutamine specificity residues [chemical binding]; other site
525909001309	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
525909001310	ATP Binding subdomain [chemical binding]; other site
525909001311	Ligand Binding sites [chemical binding]; other site
525909001312	Dimerization subdomain; other site
525909001313	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
525909001314	Part of AAA domain; Region: AAA_19; pfam13245
525909001315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909001316	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
525909001317	NAD(P) binding site [chemical binding]; other site
525909001318	active site
525909001319	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
525909001320	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
525909001321	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
525909001322	DXD motif; other site
525909001323	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
525909001324	active site lid residues [active]
525909001325	substrate binding pocket [chemical binding]; other site
525909001326	catalytic residues [active]
525909001327	substrate-Mg2+ binding site; other site
525909001328	aspartate-rich region 1; other site
525909001329	aspartate-rich region 2; other site
525909001330	phytoene desaturase; Region: crtI_fam; TIGR02734
525909001331	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
525909001332	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
525909001333	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
525909001334	substrate binding pocket [chemical binding]; other site
525909001335	chain length determination region; other site
525909001336	substrate-Mg2+ binding site; other site
525909001337	catalytic residues [active]
525909001338	aspartate-rich region 1; other site
525909001339	active site lid residues [active]
525909001340	aspartate-rich region 2; other site
525909001341	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
525909001342	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
525909001343	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
525909001344	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
525909001345	active site
525909001346	MgtE intracellular N domain; Region: MgtE_N; pfam03448
525909001347	FOG: CBS domain [General function prediction only]; Region: COG0517
525909001348	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
525909001349	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
525909001350	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
525909001351	Methyltransferase domain; Region: Methyltransf_31; pfam13847
525909001352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909001353	S-adenosylmethionine binding site [chemical binding]; other site
525909001354	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
525909001355	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
525909001356	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
525909001357	TPP-binding site; other site
525909001358	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
525909001359	PYR/PP interface [polypeptide binding]; other site
525909001360	dimer interface [polypeptide binding]; other site
525909001361	TPP binding site [chemical binding]; other site
525909001362	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
525909001363	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
525909001364	lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462
525909001365	beta-carotene hydroxylase; Region: PLN02601
525909001366	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
525909001367	intracellular protease, PfpI family; Region: PfpI; TIGR01382
525909001368	conserved cys residue [active]
525909001369	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
525909001370	putative deacylase active site [active]
525909001371	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
525909001372	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
525909001373	dimer interface [polypeptide binding]; other site
525909001374	putative functional site; other site
525909001375	putative MPT binding site; other site
525909001376	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
525909001377	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
525909001378	active site
525909001379	tetramer interface; other site
525909001380	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
525909001381	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
525909001382	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
525909001383	Methyltransferase domain; Region: Methyltransf_23; pfam13489
525909001384	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909001385	S-adenosylmethionine binding site [chemical binding]; other site
525909001386	Methyltransferase domain; Region: Methyltransf_24; pfam13578
525909001387	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
525909001388	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
525909001389	Zn binding site [ion binding]; other site
525909001390	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
525909001391	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
525909001392	substrate binding site [chemical binding]; other site
525909001393	ATP binding site [chemical binding]; other site
525909001394	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
525909001395	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
525909001396	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
525909001397	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
525909001398	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
525909001399	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
525909001400	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
525909001401	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
525909001402	ADP-glucose phosphorylase; Region: PLN02643
525909001403	nucleotide binding site/active site [active]
525909001404	HIT family signature motif; other site
525909001405	catalytic residue [active]
525909001406	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
525909001407	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
525909001408	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909001409	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
525909001410	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
525909001411	ligand binding site [chemical binding]; other site
525909001412	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
525909001413	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
525909001414	Walker A/P-loop; other site
525909001415	ATP binding site [chemical binding]; other site
525909001416	Q-loop/lid; other site
525909001417	ABC transporter signature motif; other site
525909001418	Walker B; other site
525909001419	D-loop; other site
525909001420	H-loop/switch region; other site
525909001421	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
525909001422	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
525909001423	Walker A/P-loop; other site
525909001424	ATP binding site [chemical binding]; other site
525909001425	Q-loop/lid; other site
525909001426	ABC transporter signature motif; other site
525909001427	Walker B; other site
525909001428	D-loop; other site
525909001429	H-loop/switch region; other site
525909001430	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
525909001431	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
525909001432	TM-ABC transporter signature motif; other site
525909001433	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
525909001434	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
525909001435	TM-ABC transporter signature motif; other site
525909001436	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
525909001437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909001438	active site
525909001439	phosphorylation site [posttranslational modification]
525909001440	intermolecular recognition site; other site
525909001441	dimerization interface [polypeptide binding]; other site
525909001442	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
525909001443	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909001444	Transposase; Region: HTH_Tnp_1; cl17663
525909001445	putative transposase OrfB; Reviewed; Region: PHA02517
525909001446	HTH-like domain; Region: HTH_21; pfam13276
525909001447	Integrase core domain; Region: rve; pfam00665
525909001448	Integrase core domain; Region: rve_3; pfam13683
525909001449	PAS domain; Region: PAS_9; pfam13426
525909001450	putative transposase OrfB; Reviewed; Region: PHA02517
525909001451	HTH-like domain; Region: HTH_21; pfam13276
525909001452	Integrase core domain; Region: rve; pfam00665
525909001453	Integrase core domain; Region: rve_3; pfam13683
525909001454	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909001455	Transposase; Region: HTH_Tnp_1; cl17663
525909001456	Phosphoesterase family; Region: Phosphoesterase; pfam04185
525909001457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909001458	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
525909001459	Walker A/P-loop; other site
525909001460	ATP binding site [chemical binding]; other site
525909001461	Q-loop/lid; other site
525909001462	ABC transporter signature motif; other site
525909001463	Walker B; other site
525909001464	D-loop; other site
525909001465	H-loop/switch region; other site
525909001466	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
525909001467	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
525909001468	Walker A/P-loop; other site
525909001469	ATP binding site [chemical binding]; other site
525909001470	Q-loop/lid; other site
525909001471	ABC transporter signature motif; other site
525909001472	Walker B; other site
525909001473	D-loop; other site
525909001474	H-loop/switch region; other site
525909001475	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
525909001476	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
525909001477	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
525909001478	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615
525909001479	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
525909001480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909001481	S-adenosylmethionine binding site [chemical binding]; other site
525909001482	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
525909001483	active site
525909001484	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
525909001485	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
525909001486	active site
525909001487	HIGH motif; other site
525909001488	KMSKS motif; other site
525909001489	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
525909001490	tRNA binding surface [nucleotide binding]; other site
525909001491	anticodon binding site; other site
525909001492	Predicted methyltransferases [General function prediction only]; Region: COG0313
525909001493	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
525909001494	putative SAM binding site [chemical binding]; other site
525909001495	putative homodimer interface [polypeptide binding]; other site
525909001496	GTP-binding protein YchF; Reviewed; Region: PRK09601
525909001497	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
525909001498	G1 box; other site
525909001499	GTP/Mg2+ binding site [chemical binding]; other site
525909001500	G2 box; other site
525909001501	Switch I region; other site
525909001502	G3 box; other site
525909001503	Switch II region; other site
525909001504	G4 box; other site
525909001505	G5 box; other site
525909001506	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
525909001507	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909001508	Walker A motif; other site
525909001509	ATP binding site [chemical binding]; other site
525909001510	Walker B motif; other site
525909001511	arginine finger; other site
525909001512	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
525909001513	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
525909001514	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
525909001515	dimer interface [polypeptide binding]; other site
525909001516	anticodon binding site; other site
525909001517	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
525909001518	motif 1; other site
525909001519	dimer interface [polypeptide binding]; other site
525909001520	active site
525909001521	motif 2; other site
525909001522	GAD domain; Region: GAD; pfam02938
525909001523	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
525909001524	active site
525909001525	motif 3; other site
525909001526	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
525909001527	active site
525909001528	SAM binding site [chemical binding]; other site
525909001529	homodimer interface [polypeptide binding]; other site
525909001530	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363
525909001531	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
525909001532	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
525909001533	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
525909001534	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
525909001535	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
525909001536	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
525909001537	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
525909001538	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
525909001539	FeS assembly protein SufB; Region: sufB; TIGR01980
525909001540	large tegument protein UL36; Provisional; Region: PHA03247
525909001541	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
525909001542	Transposase; Region: HTH_Tnp_1; cl17663
525909001543	Mrr N-terminal domain; Region: Mrr_N; pfam14338
525909001544	Restriction endonuclease; Region: Mrr_cat; pfam04471
525909001545	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
525909001546	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
525909001547	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
525909001548	dimerization interface [polypeptide binding]; other site
525909001549	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
525909001550	dimer interface [polypeptide binding]; other site
525909001551	phosphorylation site [posttranslational modification]
525909001552	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
525909001553	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
525909001554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909001555	active site
525909001556	phosphorylation site [posttranslational modification]
525909001557	intermolecular recognition site; other site
525909001558	dimerization interface [polypeptide binding]; other site
525909001559	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
525909001560	DNA binding site [nucleotide binding]
525909001561	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
525909001562	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
525909001563	protein binding site [polypeptide binding]; other site
525909001564	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
525909001565	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
525909001566	substrate binding site [chemical binding]; other site
525909001567	oxyanion hole (OAH) forming residues; other site
525909001568	trimer interface [polypeptide binding]; other site
525909001569	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
525909001570	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
525909001571	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
525909001572	[2Fe-2S] cluster binding site [ion binding]; other site
525909001573	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909001574	FeS assembly ATPase SufC; Region: sufC; TIGR01978
525909001575	Walker A/P-loop; other site
525909001576	ATP binding site [chemical binding]; other site
525909001577	Q-loop/lid; other site
525909001578	ABC transporter signature motif; other site
525909001579	Walker B; other site
525909001580	D-loop; other site
525909001581	H-loop/switch region; other site
525909001582	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
525909001583	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909001584	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
525909001585	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
525909001586	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
525909001587	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
525909001588	Walker A/P-loop; other site
525909001589	ATP binding site [chemical binding]; other site
525909001590	Q-loop/lid; other site
525909001591	ABC transporter signature motif; other site
525909001592	Walker B; other site
525909001593	D-loop; other site
525909001594	H-loop/switch region; other site
525909001595	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
525909001596	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
525909001597	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909001598	catalytic residue [active]
525909001599	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
525909001600	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
525909001601	trimerization site [polypeptide binding]; other site
525909001602	active site
525909001603	AAA ATPase domain; Region: AAA_16; pfam13191
525909001604	AAA domain; Region: AAA_22; pfam13401
525909001605	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
525909001606	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
525909001607	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
525909001608	tetrameric interface [polypeptide binding]; other site
525909001609	NAD binding site [chemical binding]; other site
525909001610	catalytic residues [active]
525909001611	substrate binding site [chemical binding]; other site
525909001612	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
525909001613	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
525909001614	AsnC family; Region: AsnC_trans_reg; pfam01037
525909001615	hypothetical protein; Provisional; Region: PRK06541
525909001616	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
525909001617	inhibitor-cofactor binding pocket; inhibition site
525909001618	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909001619	catalytic residue [active]
525909001620	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
525909001621	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
525909001622	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
525909001623	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
525909001624	G1 box; other site
525909001625	GTP/Mg2+ binding site [chemical binding]; other site
525909001626	G2 box; other site
525909001627	Switch I region; other site
525909001628	G3 box; other site
525909001629	Switch II region; other site
525909001630	G4 box; other site
525909001631	G5 box; other site
525909001632	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
525909001633	Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785
525909001634	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
525909001635	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
525909001636	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
525909001637	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
525909001638	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
525909001639	WYL domain; Region: WYL; pfam13280
525909001640	WYL domain; Region: WYL; pfam13280
525909001641	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
525909001642	MMPL family; Region: MMPL; pfam03176
525909001643	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
525909001644	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
525909001645	substrate binding site [chemical binding]; other site
525909001646	oxyanion hole (OAH) forming residues; other site
525909001647	trimer interface [polypeptide binding]; other site
525909001648	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
525909001649	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
525909001650	acyl-activating enzyme (AAE) consensus motif; other site
525909001651	AMP binding site [chemical binding]; other site
525909001652	active site
525909001653	CoA binding site [chemical binding]; other site
525909001654	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
525909001655	Guanylyl transferase CofC like; Region: CofC; cl17472
525909001656	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
525909001657	RNA/DNA hybrid binding site [nucleotide binding]; other site
525909001658	active site
525909001659	EamA-like transporter family; Region: EamA; pfam00892
525909001660	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
525909001661	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
525909001662	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
525909001663	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
525909001664	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
525909001665	ATP-grasp domain; Region: ATP-grasp_4; cl17255
525909001666	Bacterial PH domain; Region: DUF304; pfam03703
525909001667	Short C-terminal domain; Region: SHOCT; pfam09851
525909001668	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909001669	S-adenosylmethionine binding site [chemical binding]; other site
525909001670	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
525909001671	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
525909001672	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
525909001673	CoA-transferase family III; Region: CoA_transf_3; pfam02515
525909001674	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
525909001675	AAA-like domain; Region: AAA_10; pfam12846
525909001676	Walker A motif; other site
525909001677	ATP binding site [chemical binding]; other site
525909001678	Walker B motif; other site
525909001679	Ion channel; Region: Ion_trans_2; pfam07885
525909001680	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
525909001681	TrkA-N domain; Region: TrkA_N; pfam02254
525909001682	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
525909001683	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
525909001684	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
525909001685	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
525909001686	catalytic triad [active]
525909001687	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
525909001688	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
525909001689	Catalytic site [active]
525909001690	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
525909001691	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
525909001692	active site
525909001693	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
525909001694	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
525909001695	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
525909001696	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
525909001697	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
525909001698	active site
525909001699	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
525909001700	Coenzyme A binding pocket [chemical binding]; other site
525909001701	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
525909001702	GIY-YIG motif/motif A; other site
525909001703	putative active site [active]
525909001704	putative metal binding site [ion binding]; other site
525909001705	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
525909001706	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
525909001707	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
525909001708	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
525909001709	Malic enzyme, N-terminal domain; Region: malic; pfam00390
525909001710	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
525909001711	NAD(P) binding pocket [chemical binding]; other site
525909001712	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
525909001713	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
525909001714	active site
525909001715	DNA binding site [nucleotide binding]
525909001716	Int/Topo IB signature motif; other site
525909001717	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
525909001718	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
525909001719	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
525909001720	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
525909001721	DNA binding residues [nucleotide binding]
525909001722	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
525909001723	rRNA interaction site [nucleotide binding]; other site
525909001724	S8 interaction site; other site
525909001725	putative laminin-1 binding site; other site
525909001726	elongation factor Ts; Provisional; Region: tsf; PRK09377
525909001727	UBA/TS-N domain; Region: UBA; pfam00627
525909001728	Elongation factor TS; Region: EF_TS; pfam00889
525909001729	Elongation factor TS; Region: EF_TS; pfam00889
525909001730	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
525909001731	putative nucleotide binding site [chemical binding]; other site
525909001732	uridine monophosphate binding site [chemical binding]; other site
525909001733	homohexameric interface [polypeptide binding]; other site
525909001734	ribosome recycling factor; Reviewed; Region: frr; PRK00083
525909001735	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
525909001736	hinge region; other site
525909001737	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
525909001738	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
525909001739	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
525909001740	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
525909001741	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
525909001742	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
525909001743	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
525909001744	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
525909001745	active site
525909001746	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
525909001747	protein binding site [polypeptide binding]; other site
525909001748	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
525909001749	putative substrate binding region [chemical binding]; other site
525909001750	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
525909001751	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
525909001752	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
525909001753	prolyl-tRNA synthetase; Provisional; Region: PRK09194
525909001754	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
525909001755	motif 1; other site
525909001756	dimer interface [polypeptide binding]; other site
525909001757	active site
525909001758	motif 2; other site
525909001759	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
525909001760	putative deacylase active site [active]
525909001761	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
525909001762	active site
525909001763	motif 3; other site
525909001764	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
525909001765	anticodon binding site; other site
525909001766	Sm and related proteins; Region: Sm_like; cl00259
525909001767	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
525909001768	NusA N-terminal domain; Region: NusA_N; pfam08529
525909001769	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
525909001770	RNA binding site [nucleotide binding]; other site
525909001771	homodimer interface [polypeptide binding]; other site
525909001772	NusA-like KH domain; Region: KH_5; pfam13184
525909001773	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
525909001774	G-X-X-G motif; other site
525909001775	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
525909001776	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
525909001777	translation initiation factor IF-2; Region: IF-2; TIGR00487
525909001778	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
525909001779	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
525909001780	G1 box; other site
525909001781	putative GEF interaction site [polypeptide binding]; other site
525909001782	GTP/Mg2+ binding site [chemical binding]; other site
525909001783	Switch I region; other site
525909001784	G2 box; other site
525909001785	G3 box; other site
525909001786	Switch II region; other site
525909001787	G4 box; other site
525909001788	G5 box; other site
525909001789	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
525909001790	Translation-initiation factor 2; Region: IF-2; pfam11987
525909001791	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
525909001792	Ribosome-binding factor A; Region: RBFA; pfam02033
525909001793	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
525909001794	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
525909001795	RNA binding site [nucleotide binding]; other site
525909001796	active site
525909001797	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
525909001798	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
525909001799	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
525909001800	active site
525909001801	Riboflavin kinase; Region: Flavokinase; smart00904
525909001802	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
525909001803	16S/18S rRNA binding site [nucleotide binding]; other site
525909001804	S13e-L30e interaction site [polypeptide binding]; other site
525909001805	25S rRNA binding site [nucleotide binding]; other site
525909001806	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
525909001807	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
525909001808	oligomer interface [polypeptide binding]; other site
525909001809	RNA binding site [nucleotide binding]; other site
525909001810	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
525909001811	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
525909001812	RNase E interface [polypeptide binding]; other site
525909001813	trimer interface [polypeptide binding]; other site
525909001814	active site
525909001815	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
525909001816	putative nucleic acid binding region [nucleotide binding]; other site
525909001817	G-X-X-G motif; other site
525909001818	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
525909001819	hypothetical protein; Provisional; Region: PRK08582
525909001820	RNA binding site [nucleotide binding]; other site
525909001821	domain interface; other site
525909001822	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
525909001823	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
525909001824	active site
525909001825	dimerization interface [polypeptide binding]; other site
525909001826	dihydrodipicolinate reductase; Provisional; Region: PRK00048
525909001827	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
525909001828	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
525909001829	dihydrodipicolinate synthase; Region: dapA; TIGR00674
525909001830	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
525909001831	dimer interface [polypeptide binding]; other site
525909001832	active site
525909001833	catalytic residue [active]
525909001834	conserved hypothetical protein; Region: MG423; TIGR00649
525909001835	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
525909001836	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
525909001837	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
525909001838	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
525909001839	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
525909001840	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
525909001841	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
525909001842	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
525909001843	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
525909001844	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
525909001845	competence damage-inducible protein A; Provisional; Region: PRK00549
525909001846	putative MPT binding site; other site
525909001847	Competence-damaged protein; Region: CinA; pfam02464
525909001848	recombinase A; Provisional; Region: recA; PRK09354
525909001849	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
525909001850	hexamer interface [polypeptide binding]; other site
525909001851	Walker A motif; other site
525909001852	ATP binding site [chemical binding]; other site
525909001853	Walker B motif; other site
525909001854	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
525909001855	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
525909001856	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
525909001857	FeS/SAM binding site; other site
525909001858	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
525909001859	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
525909001860	metal binding site [ion binding]; metal-binding site
525909001861	substrate binding pocket [chemical binding]; other site
525909001862	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639
525909001863	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
525909001864	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
525909001865	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
525909001866	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
525909001867	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
525909001868	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
525909001869	HflX GTPase family; Region: HflX; cd01878
525909001870	G1 box; other site
525909001871	GTP/Mg2+ binding site [chemical binding]; other site
525909001872	Switch I region; other site
525909001873	G2 box; other site
525909001874	G3 box; other site
525909001875	Switch II region; other site
525909001876	G4 box; other site
525909001877	G5 box; other site
525909001878	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
525909001879	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
525909001880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909001881	homodimer interface [polypeptide binding]; other site
525909001882	catalytic residue [active]
525909001883	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
525909001884	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
525909001885	trimer interface [polypeptide binding]; other site
525909001886	active site
525909001887	substrate binding site [chemical binding]; other site
525909001888	CoA binding site [chemical binding]; other site
525909001889	succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900
525909001890	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
525909001891	metal binding site [ion binding]; metal-binding site
525909001892	putative transposase OrfB; Reviewed; Region: PHA02517
525909001893	HTH-like domain; Region: HTH_21; pfam13276
525909001894	Integrase core domain; Region: rve; pfam00665
525909001895	Integrase core domain; Region: rve_3; pfam13683
525909001896	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909001897	Transposase; Region: HTH_Tnp_1; cl17663
525909001898	Helix-turn-helix domain; Region: HTH_38; pfam13936
525909001899	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
525909001900	NMT1/THI5 like; Region: NMT1; pfam09084
525909001901	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
525909001902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
525909001903	ABC-ATPase subunit interface; other site
525909001904	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
525909001905	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
525909001906	Walker A/P-loop; other site
525909001907	ATP binding site [chemical binding]; other site
525909001908	Q-loop/lid; other site
525909001909	ABC transporter signature motif; other site
525909001910	Walker B; other site
525909001911	D-loop; other site
525909001912	H-loop/switch region; other site
525909001913	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909001914	putative DNA binding site [nucleotide binding]; other site
525909001915	LexA repressor; Validated; Region: PRK00215
525909001916	putative Zn2+ binding site [ion binding]; other site
525909001917	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
525909001918	Catalytic site [active]
525909001919	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
525909001920	ATP cone domain; Region: ATP-cone; pfam03477
525909001921	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
525909001922	hydrophobic ligand binding site; other site
525909001923	putative transposase OrfB; Reviewed; Region: PHA02517
525909001924	HTH-like domain; Region: HTH_21; pfam13276
525909001925	Integrase core domain; Region: rve; pfam00665
525909001926	Integrase core domain; Region: rve_3; pfam13683
525909001927	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909001928	Transposase; Region: HTH_Tnp_1; cl17663
525909001929	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
525909001930	homotetrameric interface [polypeptide binding]; other site
525909001931	putative active site [active]
525909001932	metal binding site [ion binding]; metal-binding site
525909001933	Transposase; Region: HTH_Tnp_1; pfam01527
525909001934	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
525909001935	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
525909001936	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909001937	catalytic residue [active]
525909001938	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
525909001939	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
525909001940	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
525909001941	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
525909001942	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
525909001943	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
525909001944	putative transposase OrfB; Reviewed; Region: PHA02517
525909001945	HTH-like domain; Region: HTH_21; pfam13276
525909001946	Integrase core domain; Region: rve; pfam00665
525909001947	Integrase core domain; Region: rve_3; pfam13683
525909001948	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909001949	Transposase; Region: HTH_Tnp_1; cl17663
525909001950	putative transposase OrfB; Reviewed; Region: PHA02517
525909001951	HTH-like domain; Region: HTH_21; pfam13276
525909001952	Integrase core domain; Region: rve; pfam00665
525909001953	Integrase core domain; Region: rve_3; pfam13683
525909001954	thiamine monophosphate kinase; Provisional; Region: PRK05731
525909001955	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
525909001956	ATP binding site [chemical binding]; other site
525909001957	dimerization interface [polypeptide binding]; other site
525909001958	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
525909001959	active site
525909001960	substrate-binding site [chemical binding]; other site
525909001961	metal-binding site [ion binding]
525909001962	GTP binding site [chemical binding]; other site
525909001963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909001964	Major Facilitator Superfamily; Region: MFS_1; pfam07690
525909001965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909001966	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
525909001967	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
525909001968	active site
525909001969	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
525909001970	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
525909001971	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
525909001972	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
525909001973	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
525909001974	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
525909001975	hexamer interface [polypeptide binding]; other site
525909001976	ligand binding site [chemical binding]; other site
525909001977	putative active site [active]
525909001978	NAD(P) binding site [chemical binding]; other site
525909001979	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
525909001980	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
525909001981	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
525909001982	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
525909001983	inhibitor-cofactor binding pocket; inhibition site
525909001984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909001985	catalytic residue [active]
525909001986	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
525909001987	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
525909001988	dimerization interface [polypeptide binding]; other site
525909001989	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
525909001990	dimer interface [polypeptide binding]; other site
525909001991	phosphorylation site [posttranslational modification]
525909001992	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
525909001993	ATP binding site [chemical binding]; other site
525909001994	Mg2+ binding site [ion binding]; other site
525909001995	G-X-G motif; other site
525909001996	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
525909001997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909001998	active site
525909001999	phosphorylation site [posttranslational modification]
525909002000	intermolecular recognition site; other site
525909002001	dimerization interface [polypeptide binding]; other site
525909002002	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
525909002003	DNA binding site [nucleotide binding]
525909002004	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
525909002005	FMN binding site [chemical binding]; other site
525909002006	dimer interface [polypeptide binding]; other site
525909002007	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
525909002008	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
525909002009	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
525909002010	ATP-grasp domain; Region: ATP-grasp_4; cl17255
525909002011	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
525909002012	ATP-grasp domain; Region: ATP-grasp_4; cl17255
525909002013	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
525909002014	thiamine phosphate binding site [chemical binding]; other site
525909002015	active site
525909002016	pyrophosphate binding site [ion binding]; other site
525909002017	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
525909002018	minor groove reading motif; other site
525909002019	helix-hairpin-helix signature motif; other site
525909002020	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
525909002021	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
525909002022	dimer interface [polypeptide binding]; other site
525909002023	TPP-binding site [chemical binding]; other site
525909002024	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
525909002025	active site
525909002026	RNA/DNA hybrid binding site [nucleotide binding]; other site
525909002027	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909002028	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
525909002029	NAD(P) binding site [chemical binding]; other site
525909002030	active site
525909002031	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
525909002032	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
525909002033	active site
525909002034	catalytic tetrad [active]
525909002035	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
525909002036	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909002037	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
525909002038	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
525909002039	E3 interaction surface; other site
525909002040	lipoyl attachment site [posttranslational modification]; other site
525909002041	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
525909002042	e3 binding domain; Region: E3_binding; pfam02817
525909002043	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
525909002044	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
525909002045	lipoyl synthase; Provisional; Region: PRK05481
525909002046	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
525909002047	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
525909002048	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
525909002049	active site
525909002050	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
525909002051	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
525909002052	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
525909002053	protein binding site [polypeptide binding]; other site
525909002054	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
525909002055	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
525909002056	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
525909002057	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
525909002058	substrate binding pocket [chemical binding]; other site
525909002059	dimer interface [polypeptide binding]; other site
525909002060	inhibitor binding site; inhibition site
525909002061	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
525909002062	B12 binding site [chemical binding]; other site
525909002063	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
525909002064	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
525909002065	multifunctional aminopeptidase A; Provisional; Region: PRK00913
525909002066	interface (dimer of trimers) [polypeptide binding]; other site
525909002067	Substrate-binding/catalytic site; other site
525909002068	Zn-binding sites [ion binding]; other site
525909002069	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
525909002070	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
525909002071	aromatic arch; other site
525909002072	DCoH dimer interaction site [polypeptide binding]; other site
525909002073	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
525909002074	DCoH tetramer interaction site [polypeptide binding]; other site
525909002075	substrate binding site [chemical binding]; other site
525909002076	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762
525909002077	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
525909002078	active site residue [active]
525909002079	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
525909002080	ATP binding site [chemical binding]; other site
525909002081	substrate interface [chemical binding]; other site
525909002082	Nitroreductase family; Region: Nitroreductase; pfam00881
525909002083	FMN binding site [chemical binding]; other site
525909002084	dimer interface [polypeptide binding]; other site
525909002085	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
525909002086	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
525909002087	ATP-grasp domain; Region: ATP-grasp_4; cl17255
525909002088	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
525909002089	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
525909002090	carboxyltransferase (CT) interaction site; other site
525909002091	biotinylation site [posttranslational modification]; other site
525909002092	biotin--protein ligase; Provisional; Region: PRK08330
525909002093	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
525909002094	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
525909002095	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
525909002096	active site
525909002097	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
525909002098	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
525909002099	substrate binding site; other site
525909002100	metal-binding site
525909002101	Oligomer interface; other site
525909002102	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
525909002103	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
525909002104	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
525909002105	NAD binding site [chemical binding]; other site
525909002106	substrate binding site [chemical binding]; other site
525909002107	homodimer interface [polypeptide binding]; other site
525909002108	active site
525909002109	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
525909002110	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
525909002111	NADP binding site [chemical binding]; other site
525909002112	active site
525909002113	putative substrate binding site [chemical binding]; other site
525909002114	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
525909002115	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
525909002116	active site
525909002117	glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
525909002118	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
525909002119	active site
525909002120	Substrate binding site; other site
525909002121	Mg++ binding site; other site
525909002122	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909002123	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
525909002124	NAD(P) binding site [chemical binding]; other site
525909002125	active site
525909002126	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
525909002127	GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
525909002128	LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
525909002129	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
525909002130	dimer interface [polypeptide binding]; other site
525909002131	phosphate binding site [ion binding]; other site
525909002132	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
525909002133	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
525909002134	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
525909002135	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
525909002136	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
525909002137	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
525909002138	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
525909002139	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
525909002140	NADP-binding site; other site
525909002141	homotetramer interface [polypeptide binding]; other site
525909002142	substrate binding site [chemical binding]; other site
525909002143	homodimer interface [polypeptide binding]; other site
525909002144	active site
525909002145	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
525909002146	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
525909002147	Probable Catalytic site; other site
525909002148	metal-binding site
525909002149	RibD C-terminal domain; Region: RibD_C; cl17279
525909002150	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
525909002151	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
525909002152	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
525909002153	dimerization interface [polypeptide binding]; other site
525909002154	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
525909002155	dimer interface [polypeptide binding]; other site
525909002156	putative CheW interface [polypeptide binding]; other site
525909002157	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
525909002158	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
525909002159	active site
525909002160	Ap6A binding site [chemical binding]; other site
525909002161	nudix motif; other site
525909002162	metal binding site [ion binding]; metal-binding site
525909002163	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
525909002164	active site
525909002165	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
525909002166	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
525909002167	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
525909002168	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
525909002169	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
525909002170	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
525909002171	putative homodimer interface [polypeptide binding]; other site
525909002172	putative homotetramer interface [polypeptide binding]; other site
525909002173	putative allosteric switch controlling residues; other site
525909002174	putative metal binding site [ion binding]; other site
525909002175	putative homodimer-homodimer interface [polypeptide binding]; other site
525909002176	trigger factor; Provisional; Region: tig; PRK01490
525909002177	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
525909002178	Clp protease; Region: CLP_protease; pfam00574
525909002179	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
525909002180	oligomer interface [polypeptide binding]; other site
525909002181	active site residues [active]
525909002182	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
525909002183	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
525909002184	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909002185	Walker A motif; other site
525909002186	ATP binding site [chemical binding]; other site
525909002187	Walker B motif; other site
525909002188	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
525909002189	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
525909002190	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
525909002191	active site
525909002192	multimer interface [polypeptide binding]; other site
525909002193	rod shape-determining protein MreB; Provisional; Region: PRK13927
525909002194	MreB and similar proteins; Region: MreB_like; cd10225
525909002195	nucleotide binding site [chemical binding]; other site
525909002196	Mg binding site [ion binding]; other site
525909002197	putative protofilament interaction site [polypeptide binding]; other site
525909002198	RodZ interaction site [polypeptide binding]; other site
525909002199	rod shape-determining protein MreC; Provisional; Region: PRK13922
525909002200	rod shape-determining protein MreC; Region: MreC; pfam04085
525909002201	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
525909002202	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
525909002203	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
525909002204	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
525909002205	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
525909002206	homodimer interface [polypeptide binding]; other site
525909002207	oligonucleotide binding site [chemical binding]; other site
525909002208	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
525909002209	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
525909002210	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
525909002211	GTP1/OBG; Region: GTP1_OBG; pfam01018
525909002212	Obg GTPase; Region: Obg; cd01898
525909002213	G1 box; other site
525909002214	GTP/Mg2+ binding site [chemical binding]; other site
525909002215	Switch I region; other site
525909002216	G2 box; other site
525909002217	G3 box; other site
525909002218	Switch II region; other site
525909002219	G4 box; other site
525909002220	G5 box; other site
525909002221	gamma-glutamyl kinase; Provisional; Region: PRK05429
525909002222	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
525909002223	nucleotide binding site [chemical binding]; other site
525909002224	homotetrameric interface [polypeptide binding]; other site
525909002225	putative phosphate binding site [ion binding]; other site
525909002226	putative allosteric binding site; other site
525909002227	PUA domain; Region: PUA; pfam01472
525909002228	Protein of unknown function (DUF664); Region: DUF664; pfam04978
525909002229	DinB superfamily; Region: DinB_2; pfam12867
525909002230	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
525909002231	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
525909002232	Walker A/P-loop; other site
525909002233	ATP binding site [chemical binding]; other site
525909002234	Q-loop/lid; other site
525909002235	ABC transporter signature motif; other site
525909002236	Walker B; other site
525909002237	D-loop; other site
525909002238	H-loop/switch region; other site
525909002239	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
525909002240	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
525909002241	Walker A/P-loop; other site
525909002242	ATP binding site [chemical binding]; other site
525909002243	Q-loop/lid; other site
525909002244	ABC transporter signature motif; other site
525909002245	Walker B; other site
525909002246	D-loop; other site
525909002247	H-loop/switch region; other site
525909002248	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
525909002249	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
525909002250	TM-ABC transporter signature motif; other site
525909002251	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
525909002252	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
525909002253	TM-ABC transporter signature motif; other site
525909002254	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
525909002255	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
525909002256	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
525909002257	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
525909002258	putative catalytic cysteine [active]
525909002259	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
525909002260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909002261	Walker A motif; other site
525909002262	ATP binding site [chemical binding]; other site
525909002263	Walker B motif; other site
525909002264	arginine finger; other site
525909002265	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
525909002266	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
525909002267	active site
525909002268	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
525909002269	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
525909002270	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
525909002271	Oligomerisation domain; Region: Oligomerisation; pfam02410
525909002272	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
525909002273	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
525909002274	active site
525909002275	(T/H)XGH motif; other site
525909002276	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
525909002277	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
525909002278	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
525909002279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909002280	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
525909002281	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
525909002282	active sites [active]
525909002283	tetramer interface [polypeptide binding]; other site
525909002284	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
525909002285	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
525909002286	active site 2 [active]
525909002287	active site 1 [active]
525909002288	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
525909002289	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
525909002290	acyl-activating enzyme (AAE) consensus motif; other site
525909002291	AMP binding site [chemical binding]; other site
525909002292	active site
525909002293	CoA binding site [chemical binding]; other site
525909002294	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
525909002295	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
525909002296	putative active site [active]
525909002297	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
525909002298	putative active site [active]
525909002299	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
525909002300	active site
525909002301	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
525909002302	Precorrin-8X methylmutase; Region: CbiC; pfam02570
525909002303	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
525909002304	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
525909002305	active site
525909002306	SAM binding site [chemical binding]; other site
525909002307	homodimer interface [polypeptide binding]; other site
525909002308	fumarylacetoacetase; Region: PLN02856
525909002309	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
525909002310	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
525909002311	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
525909002312	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
525909002313	Walker A motif; other site
525909002314	homodimer interface [polypeptide binding]; other site
525909002315	ATP binding site [chemical binding]; other site
525909002316	hydroxycobalamin binding site [chemical binding]; other site
525909002317	Walker B motif; other site
525909002318	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
525909002319	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
525909002320	conserved cys residue [active]
525909002321	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
525909002322	active site
525909002323	SAM binding site [chemical binding]; other site
525909002324	homodimer interface [polypeptide binding]; other site
525909002325	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
525909002326	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
525909002327	active site
525909002328	putative homodimer interface [polypeptide binding]; other site
525909002329	SAM binding site [chemical binding]; other site
525909002330	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
525909002331	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
525909002332	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
525909002333	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
525909002334	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
525909002335	active site
525909002336	Zn binding site [ion binding]; other site
525909002337	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
525909002338	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
525909002339	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
525909002340	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
525909002341	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
525909002342	cobyric acid synthase; Provisional; Region: PRK00784
525909002343	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
525909002344	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
525909002345	catalytic triad [active]
525909002346	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
525909002347	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
525909002348	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
525909002349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909002350	Walker A motif; other site
525909002351	ATP binding site [chemical binding]; other site
525909002352	Walker B motif; other site
525909002353	arginine finger; other site
525909002354	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
525909002355	metal ion-dependent adhesion site (MIDAS); other site
525909002356	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
525909002357	Fe-S cluster binding site [ion binding]; other site
525909002358	DNA binding site [nucleotide binding]
525909002359	active site
525909002360	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
525909002361	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909002362	metal binding site [ion binding]; metal-binding site
525909002363	active site
525909002364	I-site; other site
525909002365	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
525909002366	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
525909002367	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
525909002368	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
525909002369	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
525909002370	[4Fe-4S] binding site [ion binding]; other site
525909002371	molybdopterin cofactor binding site; other site
525909002372	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
525909002373	molybdopterin cofactor binding site; other site
525909002374	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
525909002375	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
525909002376	TPP-binding site [chemical binding]; other site
525909002377	heterodimer interface [polypeptide binding]; other site
525909002378	tetramer interface [polypeptide binding]; other site
525909002379	phosphorylation loop region [posttranslational modification]
525909002380	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
525909002381	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
525909002382	alpha subunit interface [polypeptide binding]; other site
525909002383	TPP binding site [chemical binding]; other site
525909002384	heterodimer interface [polypeptide binding]; other site
525909002385	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
525909002386	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
525909002387	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
525909002388	E3 interaction surface; other site
525909002389	lipoyl attachment site [posttranslational modification]; other site
525909002390	e3 binding domain; Region: E3_binding; pfam02817
525909002391	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
525909002392	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
525909002393	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909002394	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
525909002395	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
525909002396	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
525909002397	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
525909002398	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
525909002399	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
525909002400	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
525909002401	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
525909002402	TAP-like protein; Region: Abhydrolase_4; pfam08386
525909002403	Transcription factor WhiB; Region: Whib; pfam02467
525909002404	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
525909002405	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
525909002406	catalytic residues [active]
525909002407	CCC1-related family of proteins; Region: CCC1_like; cl00278
525909002408	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
525909002409	Mechanosensitive ion channel; Region: MS_channel; pfam00924
525909002410	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
525909002411	putative active site [active]
525909002412	putative catalytic site [active]
525909002413	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
525909002414	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
525909002415	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
525909002416	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
525909002417	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
525909002418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909002419	S-adenosylmethionine binding site [chemical binding]; other site
525909002420	chorismate binding enzyme; Region: Chorismate_bind; cl10555
525909002421	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
525909002422	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
525909002423	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
525909002424	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
525909002425	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
525909002426	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
525909002427	GIY-YIG motif/motif A; other site
525909002428	active site
525909002429	catalytic site [active]
525909002430	putative DNA binding site [nucleotide binding]; other site
525909002431	metal binding site [ion binding]; metal-binding site
525909002432	UvrB/uvrC motif; Region: UVR; pfam02151
525909002433	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
525909002434	Methyltransferase domain; Region: Methyltransf_11; pfam08241
525909002435	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
525909002436	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
525909002437	putative substrate binding pocket [chemical binding]; other site
525909002438	dimer interface [polypeptide binding]; other site
525909002439	phosphate binding site [ion binding]; other site
525909002440	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
525909002441	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
525909002442	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
525909002443	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
525909002444	Phosphoglycerate kinase; Region: PGK; pfam00162
525909002445	substrate binding site [chemical binding]; other site
525909002446	hinge regions; other site
525909002447	ADP binding site [chemical binding]; other site
525909002448	catalytic site [active]
525909002449	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
525909002450	triosephosphate isomerase; Provisional; Region: PRK14565
525909002451	substrate binding site [chemical binding]; other site
525909002452	dimer interface [polypeptide binding]; other site
525909002453	catalytic triad [active]
525909002454	PAS fold; Region: PAS_4; pfam08448
525909002455	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
525909002456	putative active site [active]
525909002457	heme pocket [chemical binding]; other site
525909002458	HDOD domain; Region: HDOD; pfam08668
525909002459	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
525909002460	MarC family integral membrane protein; Region: MarC; pfam01914
525909002461	Cation efflux family; Region: Cation_efflux; cl00316
525909002462	Cation efflux family; Region: Cation_efflux; cl00316
525909002463	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
525909002464	dimer interface [polypeptide binding]; other site
525909002465	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
525909002466	decamer (pentamer of dimers) interface [polypeptide binding]; other site
525909002467	catalytic triad [active]
525909002468	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
525909002469	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
525909002470	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
525909002471	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
525909002472	active site
525909002473	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
525909002474	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
525909002475	catalytic site [active]
525909002476	putative active site [active]
525909002477	putative substrate binding site [chemical binding]; other site
525909002478	dimer interface [polypeptide binding]; other site
525909002479	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
525909002480	Ligand binding site; other site
525909002481	Putative Catalytic site; other site
525909002482	DXD motif; other site
525909002483	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
525909002484	trimer interface [polypeptide binding]; other site
525909002485	active site
525909002486	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
525909002487	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
525909002488	Na binding site [ion binding]; other site
525909002489	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
525909002490	Catalytic domain of Protein Kinases; Region: PKc; cd00180
525909002491	active site
525909002492	ATP binding site [chemical binding]; other site
525909002493	substrate binding site [chemical binding]; other site
525909002494	activation loop (A-loop); other site
525909002495	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
525909002496	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
525909002497	Amino acid permease; Region: AA_permease; pfam00324
525909002498	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
525909002499	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
525909002500	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
525909002501	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
525909002502	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
525909002503	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
525909002504	amphipathic channel; other site
525909002505	Asn-Pro-Ala signature motifs; other site
525909002506	glycerol kinase; Provisional; Region: glpK; PRK00047
525909002507	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
525909002508	N- and C-terminal domain interface [polypeptide binding]; other site
525909002509	active site
525909002510	MgATP binding site [chemical binding]; other site
525909002511	catalytic site [active]
525909002512	metal binding site [ion binding]; metal-binding site
525909002513	glycerol binding site [chemical binding]; other site
525909002514	homotetramer interface [polypeptide binding]; other site
525909002515	homodimer interface [polypeptide binding]; other site
525909002516	FBP binding site [chemical binding]; other site
525909002517	protein IIAGlc interface [polypeptide binding]; other site
525909002518	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
525909002519	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
525909002520	DAK2 domain; Region: Dak2; cl03685
525909002521	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
525909002522	glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377
525909002523	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
525909002524	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
525909002525	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
525909002526	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
525909002527	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
525909002528	regulatory phosphorylation site [posttranslational modification]; other site
525909002529	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
525909002530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
525909002531	dimer interface [polypeptide binding]; other site
525909002532	conserved gate region; other site
525909002533	putative PBP binding loops; other site
525909002534	ABC-ATPase subunit interface; other site
525909002535	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
525909002536	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
525909002537	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
525909002538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
525909002539	dimer interface [polypeptide binding]; other site
525909002540	conserved gate region; other site
525909002541	putative PBP binding loops; other site
525909002542	ABC-ATPase subunit interface; other site
525909002543	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
525909002544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
525909002545	dimer interface [polypeptide binding]; other site
525909002546	conserved gate region; other site
525909002547	putative PBP binding loops; other site
525909002548	ABC-ATPase subunit interface; other site
525909002549	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
525909002550	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
525909002551	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
525909002552	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
525909002553	Walker A/P-loop; other site
525909002554	ATP binding site [chemical binding]; other site
525909002555	Q-loop/lid; other site
525909002556	ABC transporter signature motif; other site
525909002557	Walker B; other site
525909002558	D-loop; other site
525909002559	H-loop/switch region; other site
525909002560	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
525909002561	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
525909002562	Walker A/P-loop; other site
525909002563	ATP binding site [chemical binding]; other site
525909002564	Q-loop/lid; other site
525909002565	ABC transporter signature motif; other site
525909002566	Walker B; other site
525909002567	D-loop; other site
525909002568	H-loop/switch region; other site
525909002569	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
525909002570	Acyltransferase family; Region: Acyl_transf_3; pfam01757
525909002571	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
525909002572	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
525909002573	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
525909002574	Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460
525909002575	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
525909002576	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
525909002577	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
525909002578	putative active site; other site
525909002579	catalytic residue [active]
525909002580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
525909002581	TPR motif; other site
525909002582	binding surface
525909002583	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
525909002584	TPR motif; other site
525909002585	binding surface
525909002586	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
525909002587	FO synthase; Reviewed; Region: fbiC; PRK09234
525909002588	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
525909002589	FeS/SAM binding site; other site
525909002590	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
525909002591	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
525909002592	FeS/SAM binding site; other site
525909002593	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
525909002594	active site
525909002595	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
525909002596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909002597	S-adenosylmethionine binding site [chemical binding]; other site
525909002598	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
525909002599	proteasome ATPase; Region: pup_AAA; TIGR03689
525909002600	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909002601	Walker A motif; other site
525909002602	ATP binding site [chemical binding]; other site
525909002603	Walker B motif; other site
525909002604	arginine finger; other site
525909002605	Pup-ligase protein; Region: Pup_ligase; pfam03136
525909002606	Pup-like protein; Region: Pup; cl05289
525909002607	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
525909002608	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
525909002609	active site
525909002610	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
525909002611	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
525909002612	active site
525909002613	Pup-ligase protein; Region: Pup_ligase; cl15463
525909002614	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
525909002615	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
525909002616	Catalytic site [active]
525909002617	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
525909002618	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
525909002619	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
525909002620	active site
525909002621	HIGH motif; other site
525909002622	dimer interface [polypeptide binding]; other site
525909002623	KMSKS motif; other site
525909002624	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
525909002625	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
525909002626	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
525909002627	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
525909002628	ATP binding site [chemical binding]; other site
525909002629	putative Mg++ binding site [ion binding]; other site
525909002630	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
525909002631	nucleotide binding region [chemical binding]; other site
525909002632	ATP-binding site [chemical binding]; other site
525909002633	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
525909002634	Thymidylate synthase complementing protein; Region: Thy1; cl03630
525909002635	Thymidylate synthase complementing protein; Region: Thy1; cl03630
525909002636	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
525909002637	nudix motif; other site
525909002638	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
525909002639	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
525909002640	dimerization interface [polypeptide binding]; other site
525909002641	mannose binding site [chemical binding]; other site
525909002642	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
525909002643	ferredoxin-NADP reductase; Provisional; Region: PRK10926
525909002644	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
525909002645	FAD binding pocket [chemical binding]; other site
525909002646	FAD binding motif [chemical binding]; other site
525909002647	phosphate binding motif [ion binding]; other site
525909002648	beta-alpha-beta structure motif; other site
525909002649	NAD binding pocket [chemical binding]; other site
525909002650	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
525909002651	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
525909002652	putative hydrophobic ligand binding site [chemical binding]; other site
525909002653	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
525909002654	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
525909002655	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909002656	homodimer interface [polypeptide binding]; other site
525909002657	catalytic residue [active]
525909002658	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
525909002659	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
525909002660	DNA-binding site [nucleotide binding]; DNA binding site
525909002661	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
525909002662	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909002663	catalytic residue [active]
525909002664	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
525909002665	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
525909002666	inhibitor-cofactor binding pocket; inhibition site
525909002667	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909002668	catalytic residue [active]
525909002669	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
525909002670	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
525909002671	tetrameric interface [polypeptide binding]; other site
525909002672	NAD binding site [chemical binding]; other site
525909002673	catalytic residues [active]
525909002674	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
525909002675	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
525909002676	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
525909002677	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
525909002678	Protein export membrane protein; Region: SecD_SecF; cl14618
525909002679	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
525909002680	Protein export membrane protein; Region: SecD_SecF; pfam02355
525909002681	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
525909002682	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
525909002683	Zn2+ binding site [ion binding]; other site
525909002684	Mg2+ binding site [ion binding]; other site
525909002685	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
525909002686	synthetase active site [active]
525909002687	NTP binding site [chemical binding]; other site
525909002688	metal binding site [ion binding]; metal-binding site
525909002689	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
525909002690	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
525909002691	amino acid transporter; Region: 2A0306; TIGR00909
525909002692	Spore germination protein; Region: Spore_permease; cl17796
525909002693	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
525909002694	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
525909002695	motif 1; other site
525909002696	active site
525909002697	motif 2; other site
525909002698	motif 3; other site
525909002699	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
525909002700	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
525909002701	YceG-like family; Region: YceG; pfam02618
525909002702	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
525909002703	dimerization interface [polypeptide binding]; other site
525909002704	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
525909002705	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
525909002706	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
525909002707	NAD(P) binding site [chemical binding]; other site
525909002708	shikimate binding site; other site
525909002709	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
525909002710	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
525909002711	Bifunctional nuclease; Region: DNase-RNase; cl00553
525909002712	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
525909002713	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
525909002714	dimerization interface [polypeptide binding]; other site
525909002715	active site
525909002716	L-aspartate oxidase; Provisional; Region: PRK06175
525909002717	FAD binding domain; Region: FAD_binding_2; pfam00890
525909002718	quinolinate synthetase; Provisional; Region: PRK09375
525909002719	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
525909002720	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
525909002721	CPxP  motif; other site
525909002722	Predicted peroxiredoxins [General function prediction only]; Region: COG2044
525909002723	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
525909002724	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
525909002725	Cysteine-rich domain; Region: CCG; pfam02754
525909002726	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
525909002727	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909002728	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
525909002729	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
525909002730	Cysteine-rich domain; Region: CCG; pfam02754
525909002731	Cysteine-rich domain; Region: CCG; pfam02754
525909002732	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
525909002733	Ligand Binding Site [chemical binding]; other site
525909002734	Electron transfer flavoprotein domain; Region: ETF; pfam01012
525909002735	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
525909002736	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
525909002737	Ligand binding site [chemical binding]; other site
525909002738	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
525909002739	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
525909002740	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
525909002741	4Fe-4S binding domain; Region: Fer4_3; pfam12798
525909002742	Cysteine-rich domain; Region: CCG; pfam02754
525909002743	glycine cleavage system protein H; Provisional; Region: PRK13380
525909002744	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
525909002745	lipoyl attachment site [posttranslational modification]; other site
525909002746	glycine cleavage system protein H; Provisional; Region: PRK13380
525909002747	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
525909002748	lipoyl attachment site [posttranslational modification]; other site
525909002749	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
525909002750	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
525909002751	iron-sulfur cluster [ion binding]; other site
525909002752	[2Fe-2S] cluster binding site [ion binding]; other site
525909002753	putative transposase OrfB; Reviewed; Region: PHA02517
525909002754	HTH-like domain; Region: HTH_21; pfam13276
525909002755	Integrase core domain; Region: rve; pfam00665
525909002756	Integrase core domain; Region: rve_3; pfam13683
525909002757	putative transposase OrfB; Reviewed; Region: PHA02517
525909002758	HTH-like domain; Region: HTH_21; pfam13276
525909002759	Integrase core domain; Region: rve; pfam00665
525909002760	Integrase core domain; Region: rve_3; pfam13683
525909002761	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909002762	Transposase; Region: HTH_Tnp_1; cl17663
525909002763	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909002764	Transposase; Region: HTH_Tnp_1; cl17663
525909002765	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755
525909002766	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
525909002767	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
525909002768	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
525909002769	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
525909002770	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
525909002771	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
525909002772	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
525909002773	helicase Cas3; Provisional; Region: PRK09694
525909002774	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
525909002775	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
525909002776	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
525909002777	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
525909002778	Walker A/P-loop; other site
525909002779	ATP binding site [chemical binding]; other site
525909002780	Q-loop/lid; other site
525909002781	ABC transporter signature motif; other site
525909002782	Walker B; other site
525909002783	D-loop; other site
525909002784	H-loop/switch region; other site
525909002785	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
525909002786	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
525909002787	TM-ABC transporter signature motif; other site
525909002788	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
525909002789	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
525909002790	Transcriptional regulators [Transcription]; Region: PurR; COG1609
525909002791	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
525909002792	DNA binding site [nucleotide binding]
525909002793	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
525909002794	dimerization interface [polypeptide binding]; other site
525909002795	ligand binding site [chemical binding]; other site
525909002796	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
525909002797	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
525909002798	substrate binding site [chemical binding]; other site
525909002799	ATP binding site [chemical binding]; other site
525909002800	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
525909002801	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
525909002802	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
525909002803	ApbE family; Region: ApbE; pfam02424
525909002804	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
525909002805	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
525909002806	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
525909002807	polyphosphate kinase; Provisional; Region: PRK05443
525909002808	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
525909002809	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
525909002810	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
525909002811	putative active site [active]
525909002812	catalytic site [active]
525909002813	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
525909002814	putative domain interface [polypeptide binding]; other site
525909002815	putative active site [active]
525909002816	catalytic site [active]
525909002817	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
525909002818	putative active site; other site
525909002819	signature motif; other site
525909002820	putative triphosphate binding site [ion binding]; other site
525909002821	exopolyphosphatase; Region: exo_poly_only; TIGR03706
525909002822	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
525909002823	FAD binding domain; Region: FAD_binding_4; pfam01565
525909002824	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
525909002825	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
525909002826	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
525909002827	active site
525909002828	dimer interface [polypeptide binding]; other site
525909002829	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
525909002830	dimer interface [polypeptide binding]; other site
525909002831	active site
525909002832	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
525909002833	putative active site [active]
525909002834	transaldolase; Provisional; Region: PRK03903
525909002835	catalytic residue [active]
525909002836	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
525909002837	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
525909002838	NADP binding site [chemical binding]; other site
525909002839	dimer interface [polypeptide binding]; other site
525909002840	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
525909002841	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909002842	Walker A/P-loop; other site
525909002843	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
525909002844	ATP binding site [chemical binding]; other site
525909002845	ATP-binding [chemical binding]; other site
525909002846	CoA-binding site [chemical binding]; other site
525909002847	HDOD domain; Region: HDOD; pfam08668
525909002848	excinuclease ABC subunit B; Provisional; Region: PRK05298
525909002849	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
525909002850	ATP binding site [chemical binding]; other site
525909002851	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
525909002852	nucleotide binding region [chemical binding]; other site
525909002853	ATP-binding site [chemical binding]; other site
525909002854	Ultra-violet resistance protein B; Region: UvrB; pfam12344
525909002855	UvrB/uvrC motif; Region: UVR; pfam02151
525909002856	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
525909002857	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
525909002858	active site residue [active]
525909002859	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
525909002860	DsrE/DsrF-like family; Region: DrsE; cl00672
525909002861	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
525909002862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909002863	NAD(P) binding site [chemical binding]; other site
525909002864	active site
525909002865	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
525909002866	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
525909002867	molybdopterin cofactor binding site; other site
525909002868	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
525909002869	putative molybdopterin cofactor binding site; other site
525909002870	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
525909002871	4Fe-4S binding domain; Region: Fer4; cl02805
525909002872	4Fe-4S binding domain; Region: Fer4_6; pfam12837
525909002873	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
525909002874	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
525909002875	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
525909002876	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
525909002877	Ligand binding site; other site
525909002878	Putative Catalytic site; other site
525909002879	DXD motif; other site
525909002880	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
525909002881	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
525909002882	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
525909002883	protein-splicing catalytic site; other site
525909002884	thioester formation/cholesterol transfer; other site
525909002885	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
525909002886	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
525909002887	Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867
525909002888	TSCPD domain; Region: TSCPD; pfam12637
525909002889	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
525909002890	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
525909002891	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909002892	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
525909002893	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
525909002894	active site residue [active]
525909002895	acyl-CoA synthetase; Validated; Region: PRK08316
525909002896	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
525909002897	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
525909002898	acyl-activating enzyme (AAE) consensus motif; other site
525909002899	putative AMP binding site [chemical binding]; other site
525909002900	putative active site [active]
525909002901	putative CoA binding site [chemical binding]; other site
525909002902	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
525909002903	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
525909002904	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
525909002905	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
525909002906	active site
525909002907	TIGR03084 family protein; Region: TIGR03084
525909002908	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
525909002909	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
525909002910	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
525909002911	substrate binding site [chemical binding]; other site
525909002912	oxyanion hole (OAH) forming residues; other site
525909002913	trimer interface [polypeptide binding]; other site
525909002914	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
525909002915	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
525909002916	ATP-grasp domain; Region: ATP-grasp_4; cl17255
525909002917	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
525909002918	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
525909002919	carboxyltransferase (CT) interaction site; other site
525909002920	biotinylation site [posttranslational modification]; other site
525909002921	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
525909002922	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
525909002923	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
525909002924	substrate binding site [chemical binding]; other site
525909002925	oxyanion hole (OAH) forming residues; other site
525909002926	trimer interface [polypeptide binding]; other site
525909002927	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
525909002928	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
525909002929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909002930	putative substrate translocation pore; other site
525909002931	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909002932	putative DNA binding site [nucleotide binding]; other site
525909002933	putative Zn2+ binding site [ion binding]; other site
525909002934	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
525909002935	substrate binding site [chemical binding]; other site
525909002936	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
525909002937	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
525909002938	Cl- selectivity filter; other site
525909002939	Cl- binding residues [ion binding]; other site
525909002940	pore gating glutamate residue; other site
525909002941	dimer interface [polypeptide binding]; other site
525909002942	tetracycline repressor protein TetR; Provisional; Region: PRK13756
525909002943	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
525909002944	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
525909002945	phosphate binding site [ion binding]; other site
525909002946	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
525909002947	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
525909002948	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
525909002949	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
525909002950	Walker A/P-loop; other site
525909002951	ATP binding site [chemical binding]; other site
525909002952	Q-loop/lid; other site
525909002953	ABC transporter signature motif; other site
525909002954	Walker B; other site
525909002955	D-loop; other site
525909002956	H-loop/switch region; other site
525909002957	HTH-like domain; Region: HTH_21; pfam13276
525909002958	Integrase core domain; Region: rve; pfam00665
525909002959	Biotin synthase-related enzyme [General function prediction only]; Region: COG2516
525909002960	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
525909002961	FeS/SAM binding site; other site
525909002962	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
525909002963	Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856
525909002964	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
525909002965	FeS/SAM binding site; other site
525909002966	glycine cleavage system protein H; Provisional; Region: PRK13380
525909002967	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
525909002968	lipoyl-biotinyl attachment site [posttranslational modification]; other site
525909002969	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
525909002970	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
525909002971	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909002972	NAD(P) binding site [chemical binding]; other site
525909002973	active site
525909002974	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
525909002975	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
525909002976	Walker A/P-loop; other site
525909002977	ATP binding site [chemical binding]; other site
525909002978	Q-loop/lid; other site
525909002979	ABC transporter signature motif; other site
525909002980	Walker B; other site
525909002981	D-loop; other site
525909002982	H-loop/switch region; other site
525909002983	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
525909002984	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909002985	Walker A/P-loop; other site
525909002986	ATP binding site [chemical binding]; other site
525909002987	Q-loop/lid; other site
525909002988	ABC transporter signature motif; other site
525909002989	Walker B; other site
525909002990	D-loop; other site
525909002991	H-loop/switch region; other site
525909002992	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909002993	Major Facilitator Superfamily; Region: MFS_1; pfam07690
525909002994	putative substrate translocation pore; other site
525909002995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909002996	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
525909002997	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
525909002998	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
525909002999	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
525909003000	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
525909003001	active site
525909003002	dimer interface [polypeptide binding]; other site
525909003003	catalytic nucleophile [active]
525909003004	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
525909003005	peptidase domain interface [polypeptide binding]; other site
525909003006	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
525909003007	active site
525909003008	catalytic triad [active]
525909003009	calcium binding site [ion binding]; other site
525909003010	OsmC-like protein; Region: OsmC; pfam02566
525909003011	Protein of unknown function (DUF3565); Region: DUF3565; pfam12088
525909003012	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
525909003013	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
525909003014	trimer interface [polypeptide binding]; other site
525909003015	putative metal binding site [ion binding]; other site
525909003016	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
525909003017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909003018	Walker A/P-loop; other site
525909003019	ATP binding site [chemical binding]; other site
525909003020	Q-loop/lid; other site
525909003021	ABC transporter signature motif; other site
525909003022	Walker B; other site
525909003023	D-loop; other site
525909003024	H-loop/switch region; other site
525909003025	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
525909003026	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909003027	metal binding site [ion binding]; metal-binding site
525909003028	active site
525909003029	I-site; other site
525909003030	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
525909003031	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
525909003032	RNA binding site [nucleotide binding]; other site
525909003033	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
525909003034	RNA binding site [nucleotide binding]; other site
525909003035	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
525909003036	RNA binding site [nucleotide binding]; other site
525909003037	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
525909003038	RNA binding site [nucleotide binding]; other site
525909003039	domain interface; other site
525909003040	DNA polymerase I; Region: pola; TIGR00593
525909003041	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
525909003042	active site
525909003043	putative 5' ssDNA interaction site; other site
525909003044	metal binding site 3; metal-binding site
525909003045	metal binding site 1 [ion binding]; metal-binding site
525909003046	metal binding site 2 [ion binding]; metal-binding site
525909003047	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
525909003048	putative DNA binding site [nucleotide binding]; other site
525909003049	putative metal binding site [ion binding]; other site
525909003050	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
525909003051	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
525909003052	active site
525909003053	DNA binding site [nucleotide binding]
525909003054	catalytic site [active]
525909003055	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
525909003056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909003057	active site
525909003058	phosphorylation site [posttranslational modification]
525909003059	intermolecular recognition site; other site
525909003060	dimerization interface [polypeptide binding]; other site
525909003061	ANTAR domain; Region: ANTAR; pfam03861
525909003062	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
525909003063	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
525909003064	FAD binding domain; Region: FAD_binding_4; pfam01565
525909003065	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
525909003066	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
525909003067	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
525909003068	carboxyltransferase (CT) interaction site; other site
525909003069	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
525909003070	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
525909003071	dimer interface [polypeptide binding]; other site
525909003072	active site
525909003073	CoA binding pocket [chemical binding]; other site
525909003074	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
525909003075	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909003076	NAD(P) binding site [chemical binding]; other site
525909003077	active site
525909003078	acyl carrier protein; Provisional; Region: acpP; PRK00982
525909003079	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
525909003080	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
525909003081	dimer interface [polypeptide binding]; other site
525909003082	active site
525909003083	choline dehydrogenase; Validated; Region: PRK02106
525909003084	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
525909003085	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
525909003086	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
525909003087	ABC1 family; Region: ABC1; cl17513
525909003088	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
525909003089	active site
525909003090	ATP binding site [chemical binding]; other site
525909003091	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
525909003092	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
525909003093	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
525909003094	substrate binding site [chemical binding]; other site
525909003095	active site
525909003096	catalytic residues [active]
525909003097	heterodimer interface [polypeptide binding]; other site
525909003098	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
525909003099	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
525909003100	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909003101	catalytic residue [active]
525909003102	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
525909003103	active site
525909003104	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
525909003105	phosphate binding site [ion binding]; other site
525909003106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909003107	putative substrate translocation pore; other site
525909003108	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
525909003109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909003110	active site
525909003111	phosphorylation site [posttranslational modification]
525909003112	intermolecular recognition site; other site
525909003113	dimerization interface [polypeptide binding]; other site
525909003114	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
525909003115	DNA binding site [nucleotide binding]
525909003116	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
525909003117	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
525909003118	dimer interface [polypeptide binding]; other site
525909003119	phosphorylation site [posttranslational modification]
525909003120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
525909003121	ATP binding site [chemical binding]; other site
525909003122	Mg2+ binding site [ion binding]; other site
525909003123	G-X-G motif; other site
525909003124	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909003125	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
525909003126	metal binding site [ion binding]; metal-binding site
525909003127	active site
525909003128	I-site; other site
525909003129	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
525909003130	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
525909003131	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
525909003132	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
525909003133	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
525909003134	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
525909003135	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
525909003136	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
525909003137	oligomerisation interface [polypeptide binding]; other site
525909003138	mobile loop; other site
525909003139	roof hairpin; other site
525909003140	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
525909003141	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
525909003142	substrate binding site [chemical binding]; other site
525909003143	glutamase interaction surface [polypeptide binding]; other site
525909003144	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
525909003145	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
525909003146	phosphate binding site [ion binding]; other site
525909003147	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
525909003148	conserved cys residue [active]
525909003149	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
525909003150	putative active site pocket [active]
525909003151	4-fold oligomerization interface [polypeptide binding]; other site
525909003152	metal binding residues [ion binding]; metal-binding site
525909003153	3-fold/trimer interface [polypeptide binding]; other site
525909003154	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
525909003155	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
525909003156	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909003157	homodimer interface [polypeptide binding]; other site
525909003158	catalytic residue [active]
525909003159	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
525909003160	histidinol dehydrogenase; Region: hisD; TIGR00069
525909003161	NAD binding site [chemical binding]; other site
525909003162	dimerization interface [polypeptide binding]; other site
525909003163	product binding site; other site
525909003164	substrate binding site [chemical binding]; other site
525909003165	zinc binding site [ion binding]; other site
525909003166	catalytic residues [active]
525909003167	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
525909003168	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
525909003169	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
525909003170	domain interfaces; other site
525909003171	active site
525909003172	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
525909003173	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909003174	catalytic residue [active]
525909003175	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
525909003176	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
525909003177	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909003178	catalytic residue [active]
525909003179	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
525909003180	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
525909003181	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
525909003182	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
525909003183	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
525909003184	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
525909003185	active site
525909003186	Substrate binding site; other site
525909003187	Mg++ binding site; other site
525909003188	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
525909003189	putative trimer interface [polypeptide binding]; other site
525909003190	putative CoA binding site [chemical binding]; other site
525909003191	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
525909003192	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
525909003193	active site
525909003194	substrate binding site [chemical binding]; other site
525909003195	metal binding site [ion binding]; metal-binding site
525909003196	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
525909003197	lipoyl attachment site [posttranslational modification]; other site
525909003198	Double zinc ribbon; Region: DZR; pfam12773
525909003199	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
525909003200	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
525909003201	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
525909003202	phosphopeptide binding site; other site
525909003203	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
525909003204	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
525909003205	DNA binding residues [nucleotide binding]
525909003206	Bifunctional nuclease; Region: DNase-RNase; pfam02577
525909003207	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
525909003208	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
525909003209	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
525909003210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909003211	putative substrate translocation pore; other site
525909003212	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
525909003213	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
525909003214	Peptidase family M50; Region: Peptidase_M50; pfam02163
525909003215	active site
525909003216	putative substrate binding region [chemical binding]; other site
525909003217	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
525909003218	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
525909003219	active site
525909003220	DNA binding site [nucleotide binding]
525909003221	Int/Topo IB signature motif; other site
525909003222	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
525909003223	dimer interface [polypeptide binding]; other site
525909003224	active site
525909003225	ADP-ribose binding site [chemical binding]; other site
525909003226	nudix motif; other site
525909003227	metal binding site [ion binding]; metal-binding site
525909003228	CTP synthetase; Validated; Region: pyrG; PRK05380
525909003229	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
525909003230	Catalytic site [active]
525909003231	active site
525909003232	UTP binding site [chemical binding]; other site
525909003233	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
525909003234	active site
525909003235	putative oxyanion hole; other site
525909003236	catalytic triad [active]
525909003237	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
525909003238	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909003239	Walker A/P-loop; other site
525909003240	ATP binding site [chemical binding]; other site
525909003241	Q-loop/lid; other site
525909003242	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909003243	ABC transporter signature motif; other site
525909003244	Walker B; other site
525909003245	D-loop; other site
525909003246	H-loop/switch region; other site
525909003247	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
525909003248	ATP-NAD kinase; Region: NAD_kinase; pfam01513
525909003249	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
525909003250	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
525909003251	RNA binding surface [nucleotide binding]; other site
525909003252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909003253	S-adenosylmethionine binding site [chemical binding]; other site
525909003254	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
525909003255	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
525909003256	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
525909003257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
525909003258	dimer interface [polypeptide binding]; other site
525909003259	conserved gate region; other site
525909003260	putative PBP binding loops; other site
525909003261	ABC-ATPase subunit interface; other site
525909003262	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
525909003263	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
525909003264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
525909003265	dimer interface [polypeptide binding]; other site
525909003266	conserved gate region; other site
525909003267	putative PBP binding loops; other site
525909003268	ABC-ATPase subunit interface; other site
525909003269	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
525909003270	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
525909003271	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
525909003272	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
525909003273	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
525909003274	active site
525909003275	catalytic residues [active]
525909003276	metal binding site [ion binding]; metal-binding site
525909003277	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
525909003278	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
525909003279	Walker A/P-loop; other site
525909003280	ATP binding site [chemical binding]; other site
525909003281	Q-loop/lid; other site
525909003282	ABC transporter signature motif; other site
525909003283	Walker B; other site
525909003284	D-loop; other site
525909003285	H-loop/switch region; other site
525909003286	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
525909003287	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
525909003288	Walker A/P-loop; other site
525909003289	ATP binding site [chemical binding]; other site
525909003290	Q-loop/lid; other site
525909003291	ABC transporter signature motif; other site
525909003292	Walker B; other site
525909003293	D-loop; other site
525909003294	H-loop/switch region; other site
525909003295	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
525909003296	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
525909003297	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
525909003298	FeS/SAM binding site; other site
525909003299	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
525909003300	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
525909003301	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
525909003302	acyl-activating enzyme (AAE) consensus motif; other site
525909003303	AMP binding site [chemical binding]; other site
525909003304	active site
525909003305	CoA binding site [chemical binding]; other site
525909003306	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
525909003307	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
525909003308	dimer interface [polypeptide binding]; other site
525909003309	acyl-activating enzyme (AAE) consensus motif; other site
525909003310	putative active site [active]
525909003311	AMP binding site [chemical binding]; other site
525909003312	putative CoA binding site [chemical binding]; other site
525909003313	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
525909003314	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
525909003315	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
525909003316	thiS-thiF/thiG interaction site; other site
525909003317	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
525909003318	phosphate binding site [ion binding]; other site
525909003319	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
525909003320	dimer interface [polypeptide binding]; other site
525909003321	substrate binding site [chemical binding]; other site
525909003322	ATP binding site [chemical binding]; other site
525909003323	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909003324	metal binding site [ion binding]; metal-binding site
525909003325	active site
525909003326	I-site; other site
525909003327	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
525909003328	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
525909003329	prephenate dehydrogenase; Validated; Region: PRK08507
525909003330	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
525909003331	Prephenate dehydratase; Region: PDT; pfam00800
525909003332	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
525909003333	putative L-Phe binding site [chemical binding]; other site
525909003334	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
525909003335	Predicted flavoprotein [General function prediction only]; Region: COG0431
525909003336	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
525909003337	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
525909003338	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
525909003339	metal-binding site [ion binding]
525909003340	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
525909003341	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
525909003342	metal-binding site [ion binding]
525909003343	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
525909003344	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
525909003345	motif II; other site
525909003346	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
525909003347	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
525909003348	Methyltransferase domain; Region: Methyltransf_31; pfam13847
525909003349	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909003350	S-adenosylmethionine binding site [chemical binding]; other site
525909003351	Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426
525909003352	polypeptide substrate binding site [polypeptide binding]; other site
525909003353	active site
525909003354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909003355	Major Facilitator Superfamily; Region: MFS_1; pfam07690
525909003356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909003357	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909003358	putative DNA binding site [nucleotide binding]; other site
525909003359	dimerization interface [polypeptide binding]; other site
525909003360	putative Zn2+ binding site [ion binding]; other site
525909003361	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
525909003362	active site residue [active]
525909003363	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
525909003364	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909003365	active site
525909003366	phosphorylation site [posttranslational modification]
525909003367	intermolecular recognition site; other site
525909003368	dimerization interface [polypeptide binding]; other site
525909003369	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
525909003370	DNA binding site [nucleotide binding]
525909003371	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
525909003372	dimer interface [polypeptide binding]; other site
525909003373	phosphorylation site [posttranslational modification]
525909003374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
525909003375	ATP binding site [chemical binding]; other site
525909003376	Mg2+ binding site [ion binding]; other site
525909003377	G-X-G motif; other site
525909003378	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
525909003379	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
525909003380	Ligand Binding Site [chemical binding]; other site
525909003381	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
525909003382	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
525909003383	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
525909003384	Soluble P-type ATPase [General function prediction only]; Region: COG4087
525909003385	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
525909003386	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
525909003387	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
525909003388	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
525909003389	ATP binding site [chemical binding]; other site
525909003390	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
525909003391	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
525909003392	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
525909003393	DNA binding residues [nucleotide binding]
525909003394	Putative zinc-finger; Region: zf-HC2; pfam13490
525909003395	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
525909003396	catalytic core [active]
525909003397	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
525909003398	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
525909003399	generic binding surface II; other site
525909003400	generic binding surface I; other site
525909003401	putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311
525909003402	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
525909003403	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
525909003404	inhibitor-cofactor binding pocket; inhibition site
525909003405	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909003406	catalytic residue [active]
525909003407	GAF domain; Region: GAF; pfam01590
525909003408	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
525909003409	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909003410	metal binding site [ion binding]; metal-binding site
525909003411	active site
525909003412	I-site; other site
525909003413	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
525909003414	NlpC/P60 family; Region: NLPC_P60; cl17555
525909003415	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
525909003416	CoA-transferase family III; Region: CoA_transf_3; pfam02515
525909003417	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
525909003418	Amidase; Region: Amidase; cl11426
525909003419	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
525909003420	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
525909003421	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
525909003422	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
525909003423	PglZ domain; Region: PglZ; pfam08665
525909003424	Predicted transcriptional regulator [Transcription]; Region: COG1959
525909003425	Transcriptional regulator; Region: Rrf2; cl17282
525909003426	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
525909003427	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
525909003428	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
525909003429	CoA binding domain; Region: CoA_binding_2; pfam13380
525909003430	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
525909003431	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
525909003432	catalytic residues [active]
525909003433	dimer interface [polypeptide binding]; other site
525909003434	succinic semialdehyde dehydrogenase; Region: PLN02278
525909003435	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
525909003436	tetramerization interface [polypeptide binding]; other site
525909003437	NAD(P) binding site [chemical binding]; other site
525909003438	catalytic residues [active]
525909003439	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
525909003440	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
525909003441	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909003442	Walker A/P-loop; other site
525909003443	ATP binding site [chemical binding]; other site
525909003444	Q-loop/lid; other site
525909003445	ABC transporter signature motif; other site
525909003446	Walker B; other site
525909003447	D-loop; other site
525909003448	H-loop/switch region; other site
525909003449	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
525909003450	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
525909003451	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
525909003452	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
525909003453	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
525909003454	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
525909003455	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
525909003456	active site
525909003457	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909003458	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
525909003459	lipoprotein signal peptidase; Provisional; Region: PRK14787
525909003460	isoleucyl-tRNA synthetase; Region: ileS; TIGR00392
525909003461	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
525909003462	HIGH motif; other site
525909003463	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
525909003464	active site
525909003465	KMSKS motif; other site
525909003466	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
525909003467	tRNA binding surface [nucleotide binding]; other site
525909003468	anticodon binding site; other site
525909003469	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
525909003470	amino acid transporter; Region: 2A0306; TIGR00909
525909003471	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
525909003472	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909003473	Walker A motif; other site
525909003474	ATP binding site [chemical binding]; other site
525909003475	Walker B motif; other site
525909003476	arginine finger; other site
525909003477	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
525909003478	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
525909003479	RuvA N terminal domain; Region: RuvA_N; pfam01330
525909003480	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
525909003481	active site
525909003482	putative DNA-binding cleft [nucleotide binding]; other site
525909003483	dimer interface [polypeptide binding]; other site
525909003484	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
525909003485	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
525909003486	catalytic triad [active]
525909003487	hypothetical protein; Validated; Region: PRK00110
525909003488	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
525909003489	conserved cys residue [active]
525909003490	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
525909003491	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
525909003492	active site
525909003493	multimer interface [polypeptide binding]; other site
525909003494	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
525909003495	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
525909003496	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
525909003497	putative acyl-acceptor binding pocket; other site
525909003498	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
525909003499	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
525909003500	elongation factor G; Reviewed; Region: PRK12740
525909003501	G1 box; other site
525909003502	GTP/Mg2+ binding site [chemical binding]; other site
525909003503	G2 box; other site
525909003504	Switch I region; other site
525909003505	G3 box; other site
525909003506	Switch II region; other site
525909003507	G4 box; other site
525909003508	G5 box; other site
525909003509	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
525909003510	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
525909003511	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
525909003512	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
525909003513	dimer interface [polypeptide binding]; other site
525909003514	putative metal binding site [ion binding]; other site
525909003515	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
525909003516	nucleotide binding site/active site [active]
525909003517	HIT family signature motif; other site
525909003518	catalytic residue [active]
525909003519	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
525909003520	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
525909003521	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
525909003522	active site
525909003523	dimer interface [polypeptide binding]; other site
525909003524	motif 1; other site
525909003525	motif 2; other site
525909003526	motif 3; other site
525909003527	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
525909003528	anticodon binding site; other site
525909003529	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
525909003530	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
525909003531	active site
525909003532	HIGH motif; other site
525909003533	nucleotide binding site [chemical binding]; other site
525909003534	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
525909003535	KMSKS motif; other site
525909003536	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
525909003537	tRNA binding surface [nucleotide binding]; other site
525909003538	anticodon binding site; other site
525909003539	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
525909003540	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
525909003541	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909003542	NAD(P) binding site [chemical binding]; other site
525909003543	active site
525909003544	Pirin; Region: Pirin; pfam02678
525909003545	Pirin-related protein [General function prediction only]; Region: COG1741
525909003546	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
525909003547	endonuclease IV; Provisional; Region: PRK01060
525909003548	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
525909003549	AP (apurinic/apyrimidinic) site pocket; other site
525909003550	DNA interaction; other site
525909003551	Metal-binding active site; metal-binding site
525909003552	DivIVA domain; Region: DivI1A_domain; TIGR03544
525909003553	YGGT family; Region: YGGT; pfam02325
525909003554	Protein of unknown function (DUF552); Region: DUF552; pfam04472
525909003555	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
525909003556	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
525909003557	catalytic residue [active]
525909003558	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
525909003559	cell division protein FtsZ; Validated; Region: PRK09330
525909003560	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
525909003561	nucleotide binding site [chemical binding]; other site
525909003562	SulA interaction site; other site
525909003563	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
525909003564	FAD binding domain; Region: FAD_binding_4; pfam01565
525909003565	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
525909003566	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
525909003567	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
525909003568	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
525909003569	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
525909003570	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
525909003571	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
525909003572	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
525909003573	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
525909003574	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
525909003575	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
525909003576	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
525909003577	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
525909003578	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
525909003579	Mg++ binding site [ion binding]; other site
525909003580	putative catalytic motif [active]
525909003581	putative substrate binding site [chemical binding]; other site
525909003582	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
525909003583	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
525909003584	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
525909003585	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
525909003586	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
525909003587	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
525909003588	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
525909003589	MraW methylase family; Region: Methyltransf_5; cl17771
525909003590	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
525909003591	cell division protein MraZ; Reviewed; Region: PRK00326
525909003592	MraZ protein; Region: MraZ; pfam02381
525909003593	MraZ protein; Region: MraZ; pfam02381
525909003594	AsnC family; Region: AsnC_trans_reg; pfam01037
525909003595	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
525909003596	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
525909003597	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
525909003598	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
525909003599	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
525909003600	active site
525909003601	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
525909003602	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
525909003603	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
525909003604	DNA primase; Validated; Region: dnaG; PRK05667
525909003605	CHC2 zinc finger; Region: zf-CHC2; pfam01807
525909003606	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
525909003607	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
525909003608	active site
525909003609	metal binding site [ion binding]; metal-binding site
525909003610	interdomain interaction site; other site
525909003611	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
525909003612	pyruvate phosphate dikinase; Provisional; Region: PRK09279
525909003613	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
525909003614	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
525909003615	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
525909003616	glycyl-tRNA synthetase; Provisional; Region: PRK04173
525909003617	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
525909003618	dimer interface [polypeptide binding]; other site
525909003619	motif 1; other site
525909003620	active site
525909003621	motif 2; other site
525909003622	motif 3; other site
525909003623	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
525909003624	anticodon binding site; other site
525909003625	Recombination protein O N terminal; Region: RecO_N; pfam11967
525909003626	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
525909003627	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
525909003628	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
525909003629	catalytic residue [active]
525909003630	putative FPP diphosphate  binding site; other site
525909003631	putative FPP binding hydrophobic cleft; other site
525909003632	dimer interface [polypeptide binding]; other site
525909003633	putative IPP diphosphate binding site; other site
525909003634	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
525909003635	heme-binding site [chemical binding]; other site
525909003636	GTPase Era; Reviewed; Region: era; PRK00089
525909003637	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
525909003638	G1 box; other site
525909003639	GTP/Mg2+ binding site [chemical binding]; other site
525909003640	Switch I region; other site
525909003641	G2 box; other site
525909003642	Switch II region; other site
525909003643	G3 box; other site
525909003644	G4 box; other site
525909003645	G5 box; other site
525909003646	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
525909003647	Domain of unknown function DUF21; Region: DUF21; pfam01595
525909003648	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
525909003649	Transporter associated domain; Region: CorC_HlyC; smart01091
525909003650	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
525909003651	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
525909003652	PhoH-like protein; Region: PhoH; pfam02562
525909003653	Helix-turn-helix domain; Region: HTH_17; pfam12728
525909003654	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
525909003655	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
525909003656	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
525909003657	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
525909003658	Walker A motif; other site
525909003659	ATP binding site [chemical binding]; other site
525909003660	Walker B motif; other site
525909003661	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
525909003662	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
525909003663	acetyl-CoA synthetase; Provisional; Region: PRK00174
525909003664	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
525909003665	active site
525909003666	CoA binding site [chemical binding]; other site
525909003667	acyl-activating enzyme (AAE) consensus motif; other site
525909003668	AMP binding site [chemical binding]; other site
525909003669	acetate binding site [chemical binding]; other site
525909003670	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
525909003671	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
525909003672	Radical SAM superfamily; Region: Radical_SAM; pfam04055
525909003673	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
525909003674	FeS/SAM binding site; other site
525909003675	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
525909003676	non-specific DNA binding site [nucleotide binding]; other site
525909003677	salt bridge; other site
525909003678	sequence-specific DNA binding site [nucleotide binding]; other site
525909003679	RNA methyltransferase; Region: Methyltrans_RNA; cl00611
525909003680	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
525909003681	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
525909003682	HSP70 interaction site [polypeptide binding]; other site
525909003683	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
525909003684	substrate binding site [polypeptide binding]; other site
525909003685	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
525909003686	Zn binding sites [ion binding]; other site
525909003687	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
525909003688	dimer interface [polypeptide binding]; other site
525909003689	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
525909003690	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
525909003691	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
525909003692	GTP-binding protein LepA; Provisional; Region: PRK05433
525909003693	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
525909003694	G1 box; other site
525909003695	putative GEF interaction site [polypeptide binding]; other site
525909003696	GTP/Mg2+ binding site [chemical binding]; other site
525909003697	Switch I region; other site
525909003698	G2 box; other site
525909003699	G3 box; other site
525909003700	Switch II region; other site
525909003701	G4 box; other site
525909003702	G5 box; other site
525909003703	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
525909003704	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
525909003705	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
525909003706	ApbE family; Region: ApbE; pfam02424
525909003707	FMN-binding domain; Region: FMN_bind; cl01081
525909003708	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
525909003709	FAD binding pocket [chemical binding]; other site
525909003710	conserved FAD binding motif [chemical binding]; other site
525909003711	phosphate binding motif [ion binding]; other site
525909003712	beta-alpha-beta structure motif; other site
525909003713	NAD binding pocket [chemical binding]; other site
525909003714	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
525909003715	DNA photolyase; Region: DNA_photolyase; pfam00875
525909003716	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
525909003717	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
525909003718	dihydropteroate synthase; Region: DHPS; TIGR01496
525909003719	substrate binding pocket [chemical binding]; other site
525909003720	dimer interface [polypeptide binding]; other site
525909003721	inhibitor binding site; inhibition site
525909003722	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
525909003723	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
525909003724	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
525909003725	active site
525909003726	catalytic tetrad [active]
525909003727	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
525909003728	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
525909003729	Leucyl/phenylalanyl-tRNA protein transferase; Region: Leu_Phe_trans; cl17317
525909003730	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
525909003731	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
525909003732	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
525909003733	Walker A/P-loop; other site
525909003734	ATP binding site [chemical binding]; other site
525909003735	Q-loop/lid; other site
525909003736	ABC transporter signature motif; other site
525909003737	Walker B; other site
525909003738	D-loop; other site
525909003739	H-loop/switch region; other site
525909003740	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
525909003741	HNH endonuclease; Region: HNH_2; pfam13391
525909003742	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909003743	Transposase; Region: HTH_Tnp_1; cl17663
525909003744	putative transposase OrfB; Reviewed; Region: PHA02517
525909003745	HTH-like domain; Region: HTH_21; pfam13276
525909003746	Integrase core domain; Region: rve; pfam00665
525909003747	Integrase core domain; Region: rve_3; pfam13683
525909003748	putative transposase OrfB; Reviewed; Region: PHA02517
525909003749	HTH-like domain; Region: HTH_21; pfam13276
525909003750	Integrase core domain; Region: rve; pfam00665
525909003751	Integrase core domain; Region: rve_3; pfam13683
525909003752	Transposase; Region: HTH_Tnp_1; cl17663
525909003753	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
525909003754	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
525909003755	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
525909003756	HIGH motif; other site
525909003757	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
525909003758	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
525909003759	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
525909003760	active site
525909003761	KMSKS motif; other site
525909003762	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
525909003763	tRNA binding surface [nucleotide binding]; other site
525909003764	Transposase domain (DUF772); Region: DUF772; pfam05598
525909003765	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
525909003766	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
525909003767	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
525909003768	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
525909003769	Transcriptional regulators [Transcription]; Region: FadR; COG2186
525909003770	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
525909003771	DNA-binding site [nucleotide binding]; DNA binding site
525909003772	FCD domain; Region: FCD; pfam07729
525909003773	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
525909003774	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
525909003775	Walker A/P-loop; other site
525909003776	ATP binding site [chemical binding]; other site
525909003777	Q-loop/lid; other site
525909003778	ABC transporter signature motif; other site
525909003779	Walker B; other site
525909003780	D-loop; other site
525909003781	H-loop/switch region; other site
525909003782	TOBE domain; Region: TOBE_2; pfam08402
525909003783	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
525909003784	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
525909003785	active site
525909003786	catalytic site [active]
525909003787	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
525909003788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
525909003789	dimer interface [polypeptide binding]; other site
525909003790	conserved gate region; other site
525909003791	putative PBP binding loops; other site
525909003792	ABC-ATPase subunit interface; other site
525909003793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
525909003794	dimer interface [polypeptide binding]; other site
525909003795	conserved gate region; other site
525909003796	putative PBP binding loops; other site
525909003797	ABC-ATPase subunit interface; other site
525909003798	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
525909003799	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
525909003800	Transcriptional regulators [Transcription]; Region: PurR; COG1609
525909003801	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
525909003802	DNA binding site [nucleotide binding]
525909003803	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
525909003804	dimerization interface [polypeptide binding]; other site
525909003805	ligand binding site [chemical binding]; other site
525909003806	serine O-acetyltransferase; Region: cysE; TIGR01172
525909003807	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
525909003808	trimer interface [polypeptide binding]; other site
525909003809	active site
525909003810	substrate binding site [chemical binding]; other site
525909003811	CoA binding site [chemical binding]; other site
525909003812	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
525909003813	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
525909003814	dimer interface [polypeptide binding]; other site
525909003815	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909003816	catalytic residue [active]
525909003817	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
525909003818	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
525909003819	minor groove reading motif; other site
525909003820	helix-hairpin-helix signature motif; other site
525909003821	substrate binding pocket [chemical binding]; other site
525909003822	active site
525909003823	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909003824	dimerization interface [polypeptide binding]; other site
525909003825	putative DNA binding site [nucleotide binding]; other site
525909003826	putative Zn2+ binding site [ion binding]; other site
525909003827	H+ Antiporter protein; Region: 2A0121; TIGR00900
525909003828	Uncharacterized conserved protein [Function unknown]; Region: COG2361
525909003829	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
525909003830	active site
525909003831	NTP binding site [chemical binding]; other site
525909003832	metal binding triad [ion binding]; metal-binding site
525909003833	antibiotic binding site [chemical binding]; other site
525909003834	PAS domain; Region: PAS_9; pfam13426
525909003835	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
525909003836	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
525909003837	dimer interface [polypeptide binding]; other site
525909003838	putative CheW interface [polypeptide binding]; other site
525909003839	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
525909003840	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
525909003841	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
525909003842	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
525909003843	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
525909003844	GTP-binding protein Der; Reviewed; Region: PRK00093
525909003845	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
525909003846	G1 box; other site
525909003847	GTP/Mg2+ binding site [chemical binding]; other site
525909003848	G2 box; other site
525909003849	Switch I region; other site
525909003850	G3 box; other site
525909003851	Switch II region; other site
525909003852	G4 box; other site
525909003853	G5 box; other site
525909003854	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
525909003855	G1 box; other site
525909003856	GTP/Mg2+ binding site [chemical binding]; other site
525909003857	Switch I region; other site
525909003858	G2 box; other site
525909003859	G3 box; other site
525909003860	Switch II region; other site
525909003861	G4 box; other site
525909003862	G5 box; other site
525909003863	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
525909003864	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
525909003865	Protein of unknown function (DUF512); Region: DUF512; pfam04459
525909003866	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
525909003867	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
525909003868	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
525909003869	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
525909003870	putative acyl-acceptor binding pocket; other site
525909003871	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
525909003872	active site
525909003873	heat shock protein HtpX; Provisional; Region: PRK02391
525909003874	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
525909003875	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
525909003876	hinge; other site
525909003877	active site
525909003878	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
525909003879	homotrimer interaction site [polypeptide binding]; other site
525909003880	active site
525909003881	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
525909003882	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
525909003883	RNA binding surface [nucleotide binding]; other site
525909003884	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
525909003885	active site
525909003886	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
525909003887	ScpA/B protein; Region: ScpA_ScpB; cl00598
525909003888	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
525909003889	Coenzyme A binding pocket [chemical binding]; other site
525909003890	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
525909003891	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
525909003892	Cysteine-rich domain; Region: CCG; pfam02754
525909003893	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
525909003894	FAD binding domain; Region: FAD_binding_4; pfam01565
525909003895	FAD binding domain; Region: FAD_binding_4; pfam01565
525909003896	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
525909003897	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909003898	malonic semialdehyde reductase; Provisional; Region: PRK10538
525909003899	NAD(P) binding site [chemical binding]; other site
525909003900	active site
525909003901	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
525909003902	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
525909003903	Zn2+ binding site [ion binding]; other site
525909003904	Mg2+ binding site [ion binding]; other site
525909003905	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
525909003906	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909003907	Predicted transcriptional regulators [Transcription]; Region: COG1695
525909003908	putative Zn2+ binding site [ion binding]; other site
525909003909	putative DNA binding site [nucleotide binding]; other site
525909003910	DsrE/DsrF-like family; Region: DrsE; cl00672
525909003911	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
525909003912	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
525909003913	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
525909003914	acyl-activating enzyme (AAE) consensus motif; other site
525909003915	acyl-activating enzyme (AAE) consensus motif; other site
525909003916	putative AMP binding site [chemical binding]; other site
525909003917	putative active site [active]
525909003918	putative CoA binding site [chemical binding]; other site
525909003919	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
525909003920	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
525909003921	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
525909003922	dimer interface [polypeptide binding]; other site
525909003923	active site
525909003924	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
525909003925	CoenzymeA binding site [chemical binding]; other site
525909003926	subunit interaction site [polypeptide binding]; other site
525909003927	PHB binding site; other site
525909003928	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
525909003929	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
525909003930	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
525909003931	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
525909003932	substrate binding site [chemical binding]; other site
525909003933	oxyanion hole (OAH) forming residues; other site
525909003934	trimer interface [polypeptide binding]; other site
525909003935	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
525909003936	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
525909003937	substrate binding site [chemical binding]; other site
525909003938	oxyanion hole (OAH) forming residues; other site
525909003939	trimer interface [polypeptide binding]; other site
525909003940	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
525909003941	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
525909003942	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
525909003943	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
525909003944	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
525909003945	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
525909003946	catalytic loop [active]
525909003947	iron binding site [ion binding]; other site
525909003948	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
525909003949	FAD binding pocket [chemical binding]; other site
525909003950	FAD binding motif [chemical binding]; other site
525909003951	phosphate binding motif [ion binding]; other site
525909003952	beta-alpha-beta structure motif; other site
525909003953	NAD binding pocket [chemical binding]; other site
525909003954	Proline dehydrogenase; Region: Pro_dh; cl03282
525909003955	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
525909003956	NAD(P) binding site [chemical binding]; other site
525909003957	catalytic residues [active]
525909003958	Major Facilitator Superfamily; Region: MFS_1; pfam07690
525909003959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909003960	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
525909003961	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
525909003962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
525909003963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
525909003964	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
525909003965	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909003966	Walker A/P-loop; other site
525909003967	ATP binding site [chemical binding]; other site
525909003968	Q-loop/lid; other site
525909003969	ABC transporter signature motif; other site
525909003970	Walker B; other site
525909003971	D-loop; other site
525909003972	H-loop/switch region; other site
525909003973	TOBE domain; Region: TOBE_2; pfam08402
525909003974	metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623
525909003975	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
525909003976	heme-binding site [chemical binding]; other site
525909003977	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
525909003978	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909003979	metal binding site [ion binding]; metal-binding site
525909003980	active site
525909003981	I-site; other site
525909003982	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
525909003983	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
525909003984	Transposase domain (DUF772); Region: DUF772; pfam05598
525909003985	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
525909003986	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
525909003987	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
525909003988	AAA domain; Region: AAA_25; pfam13481
525909003989	Walker B motif; other site
525909003990	Restriction endonuclease [Defense mechanisms]; Region: COG3587
525909003991	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
525909003992	ATP binding site [chemical binding]; other site
525909003993	putative Mg++ binding site [ion binding]; other site
525909003994	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
525909003995	DNA methylase; Region: N6_N4_Mtase; pfam01555
525909003996	DNA methylase; Region: N6_N4_Mtase; cl17433
525909003997	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
525909003998	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
525909003999	putative active site [active]
525909004000	catalytic site [active]
525909004001	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
525909004002	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
525909004003	ATP binding site [chemical binding]; other site
525909004004	putative Mg++ binding site [ion binding]; other site
525909004005	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
525909004006	nucleotide binding region [chemical binding]; other site
525909004007	ATP-binding site [chemical binding]; other site
525909004008	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
525909004009	Transposase domain (DUF772); Region: DUF772; pfam05598
525909004010	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
525909004011	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
525909004012	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
525909004013	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
525909004014	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
525909004015	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
525909004016	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
525909004017	CPxP  motif; other site
525909004018	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
525909004019	Protein of unknown function, DUF488; Region: DUF488; cl01246
525909004020	aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340
525909004021	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
525909004022	substrate binding site [chemical binding]; other site
525909004023	ligand binding site [chemical binding]; other site
525909004024	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
525909004025	substrate binding site [chemical binding]; other site
525909004026	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
525909004027	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
525909004028	DNA-binding site [nucleotide binding]; DNA binding site
525909004029	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
525909004030	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
525909004031	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
525909004032	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
525909004033	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
525909004034	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
525909004035	putative active site [active]
525909004036	allantoate amidohydrolase; Reviewed; Region: PRK09290
525909004037	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
525909004038	active site
525909004039	metal binding site [ion binding]; metal-binding site
525909004040	dimer interface [polypeptide binding]; other site
525909004041	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
525909004042	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
525909004043	active site
525909004044	urocanate hydratase; Provisional; Region: PRK05414
525909004045	imidazolonepropionase; Validated; Region: PRK09356
525909004046	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
525909004047	active site
525909004048	phage tail protein domain; Region: tail_TIGR02242
525909004049	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
525909004050	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
525909004051	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
525909004052	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
525909004053	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
525909004054	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
525909004055	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
525909004056	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
525909004057	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
525909004058	catalytic nucleophile [active]
525909004059	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
525909004060	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
525909004061	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
525909004062	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
525909004063	putative acyl-acceptor binding pocket; other site
525909004064	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
525909004065	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
525909004066	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
525909004067	NAD(P) binding site [chemical binding]; other site
525909004068	fatty acyl-CoA reductase; Region: PLN02996
525909004069	Male sterility protein; Region: NAD_binding_4; pfam07993
525909004070	NAD(P) binding site [chemical binding]; other site
525909004071	active site
525909004072	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909004073	active site
525909004074	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
525909004075	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
525909004076	phosphate:H+ symporter; Region: 2A0109; TIGR00887
525909004077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909004078	putative substrate translocation pore; other site
525909004079	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
525909004080	DJ-1 family protein; Region: not_thiJ; TIGR01383
525909004081	conserved cys residue [active]
525909004082	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909004083	Major Facilitator Superfamily; Region: MFS_1; pfam07690
525909004084	putative substrate translocation pore; other site
525909004085	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
525909004086	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
525909004087	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
525909004088	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
525909004089	conserved cys residue [active]
525909004090	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
525909004091	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
525909004092	Transcriptional regulator [Transcription]; Region: LysR; COG0583
525909004093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
525909004094	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
525909004095	dimerization interface [polypeptide binding]; other site
525909004096	short chain dehydrogenase; Provisional; Region: PRK07791
525909004097	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
525909004098	homodimer interface [polypeptide binding]; other site
525909004099	NAD binding site [chemical binding]; other site
525909004100	active site
525909004101	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
525909004102	PhoU domain; Region: PhoU; pfam01895
525909004103	PhoU domain; Region: PhoU; pfam01895
525909004104	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
525909004105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909004106	active site
525909004107	phosphorylation site [posttranslational modification]
525909004108	intermolecular recognition site; other site
525909004109	dimerization interface [polypeptide binding]; other site
525909004110	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
525909004111	DNA binding residues [nucleotide binding]
525909004112	dimerization interface [polypeptide binding]; other site
525909004113	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
525909004114	Ligand Binding Site [chemical binding]; other site
525909004115	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
525909004116	4Fe-4S binding domain; Region: Fer4; pfam00037
525909004117	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
525909004118	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
525909004119	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909004120	Flavodoxin domain; Region: Flavodoxin_5; cl17428
525909004121	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
525909004122	4Fe-4S binding domain; Region: Fer4_5; pfam12801
525909004123	Rrf2 family protein; Region: rrf2_super; TIGR00738
525909004124	Transcriptional regulator; Region: Rrf2; pfam02082
525909004125	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
525909004126	metal binding site 2 [ion binding]; metal-binding site
525909004127	putative DNA binding helix; other site
525909004128	metal binding site 1 [ion binding]; metal-binding site
525909004129	dimer interface [polypeptide binding]; other site
525909004130	structural Zn2+ binding site [ion binding]; other site
525909004131	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
525909004132	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
525909004133	active site
525909004134	catalytic tetrad [active]
525909004135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
525909004136	Amidase; Region: Amidase; cl11426
525909004137	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
525909004138	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
525909004139	ATP binding site [chemical binding]; other site
525909004140	putative Mg++ binding site [ion binding]; other site
525909004141	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
525909004142	nucleotide binding region [chemical binding]; other site
525909004143	ATP-binding site [chemical binding]; other site
525909004144	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
525909004145	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
525909004146	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
525909004147	minor groove reading motif; other site
525909004148	helix-hairpin-helix signature motif; other site
525909004149	substrate binding pocket [chemical binding]; other site
525909004150	active site
525909004151	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
525909004152	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
525909004153	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
525909004154	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
525909004155	Coenzyme A binding pocket [chemical binding]; other site
525909004156	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
525909004157	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
525909004158	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909004159	catalytic residue [active]
525909004160	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
525909004161	active site
525909004162	catalytic site [active]
525909004163	substrate binding site [chemical binding]; other site
525909004164	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
525909004165	GIY-YIG motif/motif A; other site
525909004166	active site
525909004167	catalytic site [active]
525909004168	putative DNA binding site [nucleotide binding]; other site
525909004169	metal binding site [ion binding]; metal-binding site
525909004170	UvrB/uvrC motif; Region: UVR; pfam02151
525909004171	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
525909004172	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
525909004173	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
525909004174	GAF domain; Region: GAF_3; pfam13492
525909004175	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909004176	metal binding site [ion binding]; metal-binding site
525909004177	active site
525909004178	I-site; other site
525909004179	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
525909004180	PAS domain; Region: PAS; smart00091
525909004181	PAS domain; Region: PAS_9; pfam13426
525909004182	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
525909004183	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909004184	metal binding site [ion binding]; metal-binding site
525909004185	active site
525909004186	I-site; other site
525909004187	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
525909004188	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
525909004189	active site
525909004190	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
525909004191	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
525909004192	nucleotide binding site [chemical binding]; other site
525909004193	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
525909004194	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
525909004195	ATP-grasp domain; Region: ATP-grasp_4; cl17255
525909004196	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
525909004197	Transposase domain (DUF772); Region: DUF772; pfam05598
525909004198	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
525909004199	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
525909004200	Global regulator protein family; Region: CsrA; pfam02599
525909004201	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
525909004202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909004203	Transposase; Region: HTH_Tnp_1; cl17663
525909004204	putative transposase OrfB; Reviewed; Region: PHA02517
525909004205	HTH-like domain; Region: HTH_21; pfam13276
525909004206	Integrase core domain; Region: rve; pfam00665
525909004207	Integrase core domain; Region: rve_3; pfam13683
525909004208	Transposase domain (DUF772); Region: DUF772; pfam05598
525909004209	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
525909004210	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
525909004211	Putative zinc ribbon domain; Region: DUF164; pfam02591
525909004212	RDD family; Region: RDD; pfam06271
525909004213	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
525909004214	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
525909004215	dimer interface [polypeptide binding]; other site
525909004216	substrate binding site [chemical binding]; other site
525909004217	metal binding sites [ion binding]; metal-binding site
525909004218	NifU-like domain; Region: NifU; cl00484
525909004219	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
525909004220	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
525909004221	substrate binding site [chemical binding]; other site
525909004222	oxyanion hole (OAH) forming residues; other site
525909004223	trimer interface [polypeptide binding]; other site
525909004224	cystathionine beta-lyase, eukaryotic; Region: cysta_beta_ly_E; TIGR01329
525909004225	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
525909004226	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909004227	catalytic residue [active]
525909004228	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
525909004229	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
525909004230	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
525909004231	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
525909004232	RimM N-terminal domain; Region: RimM; pfam01782
525909004233	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
525909004234	signal recognition particle protein; Provisional; Region: PRK10867
525909004235	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
525909004236	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
525909004237	P loop; other site
525909004238	GTP binding site [chemical binding]; other site
525909004239	Signal peptide binding domain; Region: SRP_SPB; pfam02978
525909004240	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
525909004241	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
525909004242	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
525909004243	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
525909004244	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
525909004245	DNA binding residues [nucleotide binding]
525909004246	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
525909004247	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
525909004248	Walker A/P-loop; other site
525909004249	ATP binding site [chemical binding]; other site
525909004250	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
525909004251	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
525909004252	ABC transporter signature motif; other site
525909004253	Walker B; other site
525909004254	D-loop; other site
525909004255	H-loop/switch region; other site
525909004256	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
525909004257	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
525909004258	DNA binding site [nucleotide binding]
525909004259	putative catalytic residues [active]
525909004260	turnover-facilitating residue; other site
525909004261	intercalation triad [nucleotide binding]; other site
525909004262	8OG recognition residue [nucleotide binding]; other site
525909004263	putative reading head residues; other site
525909004264	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
525909004265	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
525909004266	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
525909004267	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
525909004268	dimerization interface [polypeptide binding]; other site
525909004269	active site
525909004270	metal binding site [ion binding]; metal-binding site
525909004271	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
525909004272	dsRNA binding site [nucleotide binding]; other site
525909004273	acyl carrier protein; Provisional; Region: acpP; PRK00982
525909004274	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
525909004275	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
525909004276	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
525909004277	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
525909004278	active site
525909004279	(T/H)XGH motif; other site
525909004280	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
525909004281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
525909004282	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
525909004283	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
525909004284	generic binding surface II; other site
525909004285	ssDNA binding site; other site
525909004286	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
525909004287	ATP binding site [chemical binding]; other site
525909004288	putative Mg++ binding site [ion binding]; other site
525909004289	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
525909004290	nucleotide binding region [chemical binding]; other site
525909004291	ATP-binding site [chemical binding]; other site
525909004292	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
525909004293	DAK2 domain; Region: Dak2; pfam02734
525909004294	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
525909004295	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
525909004296	C-terminal domain interface [polypeptide binding]; other site
525909004297	active site
525909004298	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
525909004299	active site
525909004300	N-terminal domain interface [polypeptide binding]; other site
525909004301	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
525909004302	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
525909004303	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
525909004304	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
525909004305	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
525909004306	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
525909004307	active site
525909004308	catalytic residues [active]
525909004309	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
525909004310	Qi binding site; other site
525909004311	intrachain domain interface; other site
525909004312	interchain domain interface [polypeptide binding]; other site
525909004313	heme bH binding site [chemical binding]; other site
525909004314	heme bL binding site [chemical binding]; other site
525909004315	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
525909004316	metal binding site [ion binding]; metal-binding site
525909004317	active site
525909004318	I-site; other site
525909004319	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
525909004320	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
525909004321	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
525909004322	active site
525909004323	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
525909004324	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
525909004325	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
525909004326	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
525909004327	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
525909004328	active site
525909004329	HIGH motif; other site
525909004330	KMSKS motif; other site
525909004331	2-isopropylmalate synthase; Validated; Region: PRK00915
525909004332	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
525909004333	active site
525909004334	catalytic residues [active]
525909004335	metal binding site [ion binding]; metal-binding site
525909004336	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
525909004337	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
525909004338	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
525909004339	ligand binding site [chemical binding]; other site
525909004340	NAD binding site [chemical binding]; other site
525909004341	dimerization interface [polypeptide binding]; other site
525909004342	catalytic site [active]
525909004343	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
525909004344	putative L-serine binding site [chemical binding]; other site
525909004345	aspartate aminotransferase; Provisional; Region: PRK05764
525909004346	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
525909004347	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909004348	homodimer interface [polypeptide binding]; other site
525909004349	catalytic residue [active]
525909004350	phosphoserine aminotransferase; Provisional; Region: PRK03080
525909004351	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909004352	catalytic residue [active]
525909004353	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
525909004354	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
525909004355	hypothetical protein; Provisional; Region: PRK14812
525909004356	substrate binding site [chemical binding]; other site
525909004357	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
525909004358	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
525909004359	substrate binding site [chemical binding]; other site
525909004360	ligand binding site [chemical binding]; other site
525909004361	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
525909004362	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
525909004363	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
525909004364	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
525909004365	tartrate dehydrogenase; Region: TTC; TIGR02089
525909004366	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
525909004367	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
525909004368	homodimer interface [polypeptide binding]; other site
525909004369	substrate-cofactor binding pocket; other site
525909004370	catalytic residue [active]
525909004371	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
525909004372	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
525909004373	active site
525909004374	catalytic residues [active]
525909004375	metal binding site [ion binding]; metal-binding site
525909004376	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
525909004377	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
525909004378	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909004379	ketol-acid reductoisomerase; Provisional; Region: PRK05479
525909004380	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
525909004381	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
525909004382	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
525909004383	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
525909004384	putative valine binding site [chemical binding]; other site
525909004385	dimer interface [polypeptide binding]; other site
525909004386	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
525909004387	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
525909004388	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
525909004389	PYR/PP interface [polypeptide binding]; other site
525909004390	dimer interface [polypeptide binding]; other site
525909004391	TPP binding site [chemical binding]; other site
525909004392	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
525909004393	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
525909004394	TPP-binding site [chemical binding]; other site
525909004395	dimer interface [polypeptide binding]; other site
525909004396	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
525909004397	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
525909004398	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
525909004399	GatB domain; Region: GatB_Yqey; smart00845
525909004400	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
525909004401	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
525909004402	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
525909004403	SCP-2 sterol transfer family; Region: SCP2; pfam02036
525909004404	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
525909004405	Catalytic domain of Protein Kinases; Region: PKc; cd00180
525909004406	active site
525909004407	ATP binding site [chemical binding]; other site
525909004408	substrate binding site [chemical binding]; other site
525909004409	activation loop (A-loop); other site
525909004410	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
525909004411	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
525909004412	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
525909004413	PASTA domain; Region: PASTA; smart00740
525909004414	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
525909004415	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
525909004416	nucleotide binding pocket [chemical binding]; other site
525909004417	K-X-D-G motif; other site
525909004418	catalytic site [active]
525909004419	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
525909004420	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
525909004421	Helix-hairpin-helix motif; Region: HHH; pfam00633
525909004422	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
525909004423	Dimer interface [polypeptide binding]; other site
525909004424	BRCT sequence motif; other site
525909004425	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
525909004426	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
525909004427	Ligand Binding Site [chemical binding]; other site
525909004428	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
525909004429	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
525909004430	active site
525909004431	catalytic site [active]
525909004432	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
525909004433	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
525909004434	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
525909004435	active site
525909004436	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
525909004437	Beta-lactamase; Region: Beta-lactamase; pfam00144
525909004438	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
525909004439	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
525909004440	catalytic residues [active]
525909004441	Protein of unknown function (DUF501); Region: DUF501; cl00652
525909004442	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
525909004443	putative hydrophobic ligand binding site [chemical binding]; other site
525909004444	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
525909004445	Ligand binding site; other site
525909004446	metal-binding site
525909004447	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
525909004448	XdhC Rossmann domain; Region: XdhC_C; pfam13478
525909004449	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
525909004450	Protein of unknown function (DUF444); Region: DUF444; cl17371
525909004451	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
525909004452	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
525909004453	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909004454	Walker A motif; other site
525909004455	ATP binding site [chemical binding]; other site
525909004456	Walker B motif; other site
525909004457	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
525909004458	arginine finger; other site
525909004459	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
525909004460	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
525909004461	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
525909004462	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
525909004463	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
525909004464	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
525909004465	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
525909004466	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
525909004467	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
525909004468	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
525909004469	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
525909004470	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
525909004471	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
525909004472	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
525909004473	TM-ABC transporter signature motif; other site
525909004474	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
525909004475	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
525909004476	Walker A/P-loop; other site
525909004477	ATP binding site [chemical binding]; other site
525909004478	Q-loop/lid; other site
525909004479	ABC transporter signature motif; other site
525909004480	Walker B; other site
525909004481	D-loop; other site
525909004482	H-loop/switch region; other site
525909004483	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
525909004484	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
525909004485	putative ligand binding site [chemical binding]; other site
525909004486	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
525909004487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909004488	active site
525909004489	phosphorylation site [posttranslational modification]
525909004490	intermolecular recognition site; other site
525909004491	dimerization interface [polypeptide binding]; other site
525909004492	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
525909004493	DNA binding site [nucleotide binding]
525909004494	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
525909004495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909004496	Walker A/P-loop; other site
525909004497	ATP binding site [chemical binding]; other site
525909004498	Q-loop/lid; other site
525909004499	ABC transporter signature motif; other site
525909004500	Walker B; other site
525909004501	D-loop; other site
525909004502	H-loop/switch region; other site
525909004503	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
525909004504	dimer interface [polypeptide binding]; other site
525909004505	phosphorylation site [posttranslational modification]
525909004506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
525909004507	ATP binding site [chemical binding]; other site
525909004508	Mg2+ binding site [ion binding]; other site
525909004509	G-X-G motif; other site
525909004510	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
525909004511	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
525909004512	Family description; Region: UvrD_C_2; pfam13538
525909004513	RNA polymerase sigma factor; Provisional; Region: PRK12519
525909004514	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
525909004515	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
525909004516	DNA binding residues [nucleotide binding]
525909004517	Putative zinc-finger; Region: zf-HC2; pfam13490
525909004518	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
525909004519	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
525909004520	active site
525909004521	catalytic site [active]
525909004522	metal binding site [ion binding]; metal-binding site
525909004523	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
525909004524	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
525909004525	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
525909004526	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
525909004527	enolase; Provisional; Region: eno; PRK00077
525909004528	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
525909004529	dimer interface [polypeptide binding]; other site
525909004530	metal binding site [ion binding]; metal-binding site
525909004531	substrate binding pocket [chemical binding]; other site
525909004532	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
525909004533	active site
525909004534	SAM binding site [chemical binding]; other site
525909004535	homodimer interface [polypeptide binding]; other site
525909004536	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
525909004537	homodimer interface [polypeptide binding]; other site
525909004538	metal binding site [ion binding]; metal-binding site
525909004539	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
525909004540	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
525909004541	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
525909004542	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
525909004543	ATP binding site [chemical binding]; other site
525909004544	putative Mg++ binding site [ion binding]; other site
525909004545	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
525909004546	nucleotide binding region [chemical binding]; other site
525909004547	ATP-binding site [chemical binding]; other site
525909004548	TRCF domain; Region: TRCF; pfam03461
525909004549	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
525909004550	putative active site [active]
525909004551	catalytic residue [active]
525909004552	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
525909004553	5S rRNA interface [nucleotide binding]; other site
525909004554	CTC domain interface [polypeptide binding]; other site
525909004555	L16 interface [polypeptide binding]; other site
525909004556	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
525909004557	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
525909004558	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
525909004559	active site
525909004560	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
525909004561	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
525909004562	putative active site [active]
525909004563	putative metal binding site [ion binding]; other site
525909004564	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
525909004565	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
525909004566	active site
525909004567	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
525909004568	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
525909004569	hypothetical protein; Validated; Region: PRK07586
525909004570	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
525909004571	PYR/PP interface [polypeptide binding]; other site
525909004572	dimer interface [polypeptide binding]; other site
525909004573	TPP binding site [chemical binding]; other site
525909004574	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
525909004575	TPP-binding site [chemical binding]; other site
525909004576	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
525909004577	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
525909004578	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
525909004579	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
525909004580	putative active site [active]
525909004581	putative catalytic site [active]
525909004582	CAAX protease self-immunity; Region: Abi; pfam02517
525909004583	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
525909004584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909004585	Walker A motif; other site
525909004586	ATP binding site [chemical binding]; other site
525909004587	Walker B motif; other site
525909004588	arginine finger; other site
525909004589	Peptidase family M41; Region: Peptidase_M41; pfam01434
525909004590	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
525909004591	SCP-2 sterol transfer family; Region: SCP2; pfam02036
525909004592	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
525909004593	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
525909004594	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
525909004595	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
525909004596	active site
525909004597	PHP Thumb interface [polypeptide binding]; other site
525909004598	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
525909004599	generic binding surface II; other site
525909004600	generic binding surface I; other site
525909004601	DNA polymerase IV; Provisional; Region: PRK02794
525909004602	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
525909004603	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
525909004604	DNA-binding site [nucleotide binding]; DNA binding site
525909004605	UTRA domain; Region: UTRA; pfam07702
525909004606	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
525909004607	catalytic site [active]
525909004608	putative active site [active]
525909004609	putative substrate binding site [chemical binding]; other site
525909004610	HRDC domain; Region: HRDC; pfam00570
525909004611	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
525909004612	nucleotide binding site/active site [active]
525909004613	HIT family signature motif; other site
525909004614	catalytic residue [active]
525909004615	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
525909004616	putative active site [active]
525909004617	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
525909004618	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
525909004619	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
525909004620	active site
525909004621	HIGH motif; other site
525909004622	dimer interface [polypeptide binding]; other site
525909004623	KMSKS motif; other site
525909004624	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
525909004625	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
525909004626	PYR/PP interface [polypeptide binding]; other site
525909004627	dimer interface [polypeptide binding]; other site
525909004628	TPP binding site [chemical binding]; other site
525909004629	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
525909004630	TPP-binding site [chemical binding]; other site
525909004631	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
525909004632	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
525909004633	UbiA prenyltransferase family; Region: UbiA; pfam01040
525909004634	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
525909004635	acyl-activating enzyme (AAE) consensus motif; other site
525909004636	AMP binding site [chemical binding]; other site
525909004637	active site
525909004638	CoA binding site [chemical binding]; other site
525909004639	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
525909004640	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
525909004641	classical (c) SDRs; Region: SDR_c; cd05233
525909004642	NAD(P) binding site [chemical binding]; other site
525909004643	active site
525909004644	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
525909004645	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
525909004646	catalytic residues [active]
525909004647	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
525909004648	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
525909004649	DNA binding domain, excisionase family; Region: excise; TIGR01764
525909004650	PIN domain; Region: PIN_3; pfam13470
525909004651	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
525909004652	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
525909004653	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
525909004654	active site
525909004655	PHP Thumb interface [polypeptide binding]; other site
525909004656	metal binding site [ion binding]; metal-binding site
525909004657	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
525909004658	generic binding surface II; other site
525909004659	generic binding surface I; other site
525909004660	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129
525909004661	catalytic triad [active]
525909004662	active site nucleophile [active]
525909004663	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
525909004664	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
525909004665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909004666	catalytic residue [active]
525909004667	acetyl-CoA synthetase; Provisional; Region: PRK00174
525909004668	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
525909004669	acyl-activating enzyme (AAE) consensus motif; other site
525909004670	AMP binding site [chemical binding]; other site
525909004671	active site
525909004672	CoA binding site [chemical binding]; other site
525909004673	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
525909004674	EamA-like transporter family; Region: EamA; pfam00892
525909004675	EamA-like transporter family; Region: EamA; pfam00892
525909004676	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
525909004677	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
525909004678	catalytic residues [active]
525909004679	catalytic nucleophile [active]
525909004680	Presynaptic Site I dimer interface [polypeptide binding]; other site
525909004681	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
525909004682	Synaptic Flat tetramer interface [polypeptide binding]; other site
525909004683	Synaptic Site I dimer interface [polypeptide binding]; other site
525909004684	Fic/DOC family; Region: Fic; cl00960
525909004685	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
525909004686	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
525909004687	Transposase, Mutator family; Region: Transposase_mut; pfam00872
525909004688	Transposase, Mutator family; Region: Transposase_mut; pfam00872
525909004689	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
525909004690	active site
525909004691	DNA binding site [nucleotide binding]
525909004692	argininosuccinate lyase; Provisional; Region: PRK00855
525909004693	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
525909004694	active sites [active]
525909004695	tetramer interface [polypeptide binding]; other site
525909004696	argininosuccinate synthase; Provisional; Region: PRK13820
525909004697	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
525909004698	ANP binding site [chemical binding]; other site
525909004699	Substrate Binding Site II [chemical binding]; other site
525909004700	Substrate Binding Site I [chemical binding]; other site
525909004701	Arginine repressor [Transcription]; Region: ArgR; COG1438
525909004702	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
525909004703	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
525909004704	ornithine carbamoyltransferase; Provisional; Region: PRK00779
525909004705	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
525909004706	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
525909004707	acetylornithine aminotransferase; Provisional; Region: PRK02627
525909004708	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
525909004709	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909004710	catalytic residue [active]
525909004711	acetylglutamate kinase; Provisional; Region: PRK00942
525909004712	nucleotide binding site [chemical binding]; other site
525909004713	substrate binding site [chemical binding]; other site
525909004714	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
525909004715	heterotetramer interface [polypeptide binding]; other site
525909004716	active site pocket [active]
525909004717	cleavage site
525909004718	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
525909004719	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
525909004720	Protein of unknown function (DUF805); Region: DUF805; pfam05656
525909004721	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
525909004722	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
525909004723	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
525909004724	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
525909004725	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
525909004726	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
525909004727	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
525909004728	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
525909004729	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
525909004730	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
525909004731	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
525909004732	putative tRNA-binding site [nucleotide binding]; other site
525909004733	B3/4 domain; Region: B3_4; pfam03483
525909004734	tRNA synthetase B5 domain; Region: B5; smart00874
525909004735	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
525909004736	motif 1; other site
525909004737	dimer interface [polypeptide binding]; other site
525909004738	active site
525909004739	motif 2; other site
525909004740	motif 3; other site
525909004741	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
525909004742	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
525909004743	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
525909004744	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
525909004745	dimer interface [polypeptide binding]; other site
525909004746	motif 1; other site
525909004747	active site
525909004748	motif 2; other site
525909004749	motif 3; other site
525909004750	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
525909004751	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
525909004752	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
525909004753	23S rRNA binding site [nucleotide binding]; other site
525909004754	L21 binding site [polypeptide binding]; other site
525909004755	L13 binding site [polypeptide binding]; other site
525909004756	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
525909004757	translation initiation factor IF-3; Region: infC; TIGR00168
525909004758	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
525909004759	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
525909004760	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
525909004761	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
525909004762	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
525909004763	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
525909004764	homopentamer interface [polypeptide binding]; other site
525909004765	active site
525909004766	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
525909004767	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
525909004768	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
525909004769	dimerization interface [polypeptide binding]; other site
525909004770	active site
525909004771	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
525909004772	Lumazine binding domain; Region: Lum_binding; pfam00677
525909004773	Lumazine binding domain; Region: Lum_binding; pfam00677
525909004774	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
525909004775	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
525909004776	catalytic motif [active]
525909004777	Zn binding site [ion binding]; other site
525909004778	RibD C-terminal domain; Region: RibD_C; cl17279
525909004779	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
525909004780	MPT binding site; other site
525909004781	trimer interface [polypeptide binding]; other site
525909004782	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
525909004783	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
525909004784	putative active site [active]
525909004785	substrate binding site [chemical binding]; other site
525909004786	putative cosubstrate binding site; other site
525909004787	catalytic site [active]
525909004788	Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
525909004789	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
525909004790	active site
525909004791	catalytic residues [active]
525909004792	metal binding site [ion binding]; metal-binding site
525909004793	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
525909004794	primosome assembly protein PriA; Validated; Region: PRK05580
525909004795	S-adenosylmethionine synthetase; Validated; Region: PRK05250
525909004796	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
525909004797	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
525909004798	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
525909004799	Flavoprotein; Region: Flavoprotein; pfam02441
525909004800	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
525909004801	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
525909004802	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
525909004803	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
525909004804	catalytic site [active]
525909004805	G-X2-G-X-G-K; other site
525909004806	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
525909004807	active site
525909004808	dimer interface [polypeptide binding]; other site
525909004809	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
525909004810	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
525909004811	phosphate binding site [ion binding]; other site
525909004812	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
525909004813	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
525909004814	ATP-grasp domain; Region: ATP-grasp_4; cl17255
525909004815	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
525909004816	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
525909004817	ATP-grasp domain; Region: ATP-grasp_4; cl17255
525909004818	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
525909004819	IMP binding site; other site
525909004820	dimer interface [polypeptide binding]; other site
525909004821	partial ornithine binding site; other site
525909004822	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
525909004823	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
525909004824	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
525909004825	catalytic site [active]
525909004826	subunit interface [polypeptide binding]; other site
525909004827	dihydroorotase; Validated; Region: pyrC; PRK09357
525909004828	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
525909004829	active site
525909004830	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
525909004831	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
525909004832	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
525909004833	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
525909004834	active site
525909004835	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
525909004836	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
525909004837	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
525909004838	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
525909004839	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
525909004840	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
525909004841	catalytic residues [active]
525909004842	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
525909004843	UbiA prenyltransferase family; Region: UbiA; pfam01040
525909004844	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
525909004845	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
525909004846	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
525909004847	active site
525909004848	elongation factor P; Validated; Region: PRK00529
525909004849	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
525909004850	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
525909004851	RNA binding site [nucleotide binding]; other site
525909004852	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
525909004853	RNA binding site [nucleotide binding]; other site
525909004854	transcription antitermination factor NusB; Region: nusB; TIGR01951
525909004855	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
525909004856	Dehydroquinase class II; Region: DHquinase_II; pfam01220
525909004857	trimer interface [polypeptide binding]; other site
525909004858	active site
525909004859	dimer interface [polypeptide binding]; other site
525909004860	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
525909004861	dimer interface [polypeptide binding]; other site
525909004862	active site
525909004863	metal binding site [ion binding]; metal-binding site
525909004864	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
525909004865	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
525909004866	Tetramer interface [polypeptide binding]; other site
525909004867	active site
525909004868	FMN-binding site [chemical binding]; other site
525909004869	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
525909004870	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
525909004871	active site
525909004872	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
525909004873	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
525909004874	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
525909004875	Uncharacterized conserved protein [Function unknown]; Region: COG2353
525909004876	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
525909004877	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
525909004878	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
525909004879	Radical SAM superfamily; Region: Radical_SAM; pfam04055
525909004880	FeS/SAM binding site; other site
525909004881	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
525909004882	Family description; Region: UvrD_C_2; pfam13538
525909004883	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
525909004884	putative catalytic site [active]
525909004885	putative phosphate binding site [ion binding]; other site
525909004886	active site
525909004887	metal binding site A [ion binding]; metal-binding site
525909004888	DNA binding site [nucleotide binding]
525909004889	putative AP binding site [nucleotide binding]; other site
525909004890	putative metal binding site B [ion binding]; other site
525909004891	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
525909004892	Protein of unknown function (DUF1059); Region: DUF1059; pfam06348
525909004893	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
525909004894	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
525909004895	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
525909004896	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
525909004897	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
525909004898	TPP-binding site [chemical binding]; other site
525909004899	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
525909004900	dimer interface [polypeptide binding]; other site
525909004901	PYR/PP interface [polypeptide binding]; other site
525909004902	TPP binding site [chemical binding]; other site
525909004903	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
525909004904	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
525909004905	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
525909004906	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
525909004907	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909004908	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
525909004909	NAD(P) binding site [chemical binding]; other site
525909004910	active site
525909004911	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
525909004912	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
525909004913	putative dimer interface [polypeptide binding]; other site
525909004914	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
525909004915	ABC1 family; Region: ABC1; cl17513
525909004916	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
525909004917	FAD binding domain; Region: FAD_binding_4; pfam01565
525909004918	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
525909004919	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
525909004920	classical (c) SDRs; Region: SDR_c; cd05233
525909004921	NAD(P) binding site [chemical binding]; other site
525909004922	active site
525909004923	Stage II sporulation protein; Region: SpoIID; pfam08486
525909004924	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
525909004925	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
525909004926	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
525909004927	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
525909004928	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
525909004929	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
525909004930	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
525909004931	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
525909004932	Walker A/P-loop; other site
525909004933	ATP binding site [chemical binding]; other site
525909004934	Q-loop/lid; other site
525909004935	ABC transporter signature motif; other site
525909004936	Walker B; other site
525909004937	D-loop; other site
525909004938	H-loop/switch region; other site
525909004939	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
525909004940	Clp protease; Region: CLP_protease; pfam00574
525909004941	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
525909004942	oligomer interface [polypeptide binding]; other site
525909004943	active site residues [active]
525909004944	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
525909004945	active site
525909004946	dimerization interface [polypeptide binding]; other site
525909004947	ribonuclease PH; Reviewed; Region: rph; PRK00173
525909004948	Ribonuclease PH; Region: RNase_PH_bact; cd11362
525909004949	hexamer interface [polypeptide binding]; other site
525909004950	active site
525909004951	glutamate racemase; Provisional; Region: PRK00865
525909004952	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
525909004953	MPN+ (JAMM) motif; other site
525909004954	Zinc-binding site [ion binding]; other site
525909004955	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
525909004956	SmpB-tmRNA interface; other site
525909004957	TrkA-N domain; Region: TrkA_N; pfam02254
525909004958	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
525909004959	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
525909004960	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
525909004961	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
525909004962	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909004963	Walker A/P-loop; other site
525909004964	ATP binding site [chemical binding]; other site
525909004965	Q-loop/lid; other site
525909004966	ABC transporter signature motif; other site
525909004967	Walker B; other site
525909004968	D-loop; other site
525909004969	H-loop/switch region; other site
525909004970	peptide chain release factor 2; Validated; Region: prfB; PRK00578
525909004971	This domain is found in peptide chain release factors; Region: PCRF; smart00937
525909004972	RF-1 domain; Region: RF-1; pfam00472
525909004973	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
525909004974	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
525909004975	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
525909004976	30S subunit binding site; other site
525909004977	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
525909004978	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
525909004979	homotetramer interface [polypeptide binding]; other site
525909004980	ligand binding site [chemical binding]; other site
525909004981	catalytic site [active]
525909004982	NAD binding site [chemical binding]; other site
525909004983	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
525909004984	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
525909004985	dimer interface [polypeptide binding]; other site
525909004986	active site
525909004987	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
525909004988	dimer interface [polypeptide binding]; other site
525909004989	active site
525909004990	Trm112p-like protein; Region: Trm112p; cl01066
525909004991	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
525909004992	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
525909004993	active site
525909004994	substrate binding site [chemical binding]; other site
525909004995	metal binding site [ion binding]; metal-binding site
525909004996	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
525909004997	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
525909004998	active site
525909004999	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
525909005000	active site
525909005001	putative catalytic site [active]
525909005002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909005003	Transposase; Region: HTH_Tnp_1; cl17663
525909005004	putative transposase OrfB; Reviewed; Region: PHA02517
525909005005	HTH-like domain; Region: HTH_21; pfam13276
525909005006	Integrase core domain; Region: rve; pfam00665
525909005007	Integrase core domain; Region: rve_3; pfam13683
525909005008	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
525909005009	trehalose synthase; Region: treS_nterm; TIGR02456
525909005010	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
525909005011	active site
525909005012	catalytic site [active]
525909005013	enoyl-CoA hydratase; Provisional; Region: PRK06688
525909005014	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
525909005015	substrate binding site [chemical binding]; other site
525909005016	oxyanion hole (OAH) forming residues; other site
525909005017	trimer interface [polypeptide binding]; other site
525909005018	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
525909005019	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
525909005020	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
525909005021	putative active site [active]
525909005022	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
525909005023	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
525909005024	fumarate hydratase; Reviewed; Region: fumC; PRK00485
525909005025	aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596
525909005026	active sites [active]
525909005027	tetramer interface [polypeptide binding]; other site
525909005028	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
525909005029	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
525909005030	NAD(P) binding site [chemical binding]; other site
525909005031	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
525909005032	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
525909005033	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
525909005034	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
525909005035	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
525909005036	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
525909005037	putative active site [active]
525909005038	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
525909005039	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
525909005040	ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216
525909005041	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
525909005042	gamma subunit interface [polypeptide binding]; other site
525909005043	epsilon subunit interface [polypeptide binding]; other site
525909005044	LBP interface [polypeptide binding]; other site
525909005045	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
525909005046	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
525909005047	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
525909005048	alpha subunit interaction interface [polypeptide binding]; other site
525909005049	Walker A motif; other site
525909005050	ATP binding site [chemical binding]; other site
525909005051	Walker B motif; other site
525909005052	inhibitor binding site; inhibition site
525909005053	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
525909005054	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
525909005055	core domain interface [polypeptide binding]; other site
525909005056	delta subunit interface [polypeptide binding]; other site
525909005057	epsilon subunit interface [polypeptide binding]; other site
525909005058	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
525909005059	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
525909005060	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
525909005061	beta subunit interaction interface [polypeptide binding]; other site
525909005062	Walker A motif; other site
525909005063	ATP binding site [chemical binding]; other site
525909005064	Walker B motif; other site
525909005065	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
525909005066	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
525909005067	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
525909005068	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
525909005069	ATP synthase subunit C; Region: ATP-synt_C; cl00466
525909005070	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
525909005071	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
525909005072	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
525909005073	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
525909005074	Mg++ binding site [ion binding]; other site
525909005075	putative catalytic motif [active]
525909005076	substrate binding site [chemical binding]; other site
525909005077	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
525909005078	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
525909005079	dimer interface [polypeptide binding]; other site
525909005080	active site
525909005081	glycine-pyridoxal phosphate binding site [chemical binding]; other site
525909005082	folate binding site [chemical binding]; other site
525909005083	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
525909005084	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
525909005085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909005086	S-adenosylmethionine binding site [chemical binding]; other site
525909005087	peptide chain release factor 1; Validated; Region: prfA; PRK00591
525909005088	This domain is found in peptide chain release factors; Region: PCRF; smart00937
525909005089	RF-1 domain; Region: RF-1; pfam00472
525909005090	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
525909005091	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
525909005092	transcription termination factor Rho; Provisional; Region: PRK12608
525909005093	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
525909005094	RNA binding site [nucleotide binding]; other site
525909005095	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
525909005096	Walker A motif; other site
525909005097	ATP binding site [chemical binding]; other site
525909005098	Walker B motif; other site
525909005099	threonine synthase; Reviewed; Region: PRK06721
525909005100	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
525909005101	homodimer interface [polypeptide binding]; other site
525909005102	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909005103	catalytic residue [active]
525909005104	homoserine dehydrogenase; Provisional; Region: PRK06349
525909005105	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
525909005106	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
525909005107	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
525909005108	diaminopimelate decarboxylase; Region: lysA; TIGR01048
525909005109	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
525909005110	active site
525909005111	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
525909005112	substrate binding site [chemical binding]; other site
525909005113	catalytic residues [active]
525909005114	dimer interface [polypeptide binding]; other site
525909005115	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
525909005116	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
525909005117	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
525909005118	active site
525909005119	HIGH motif; other site
525909005120	KMSK motif region; other site
525909005121	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
525909005122	tRNA binding surface [nucleotide binding]; other site
525909005123	anticodon binding site; other site
525909005124	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
525909005125	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
525909005126	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
525909005127	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
525909005128	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
525909005129	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
525909005130	active site
525909005131	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
525909005132	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
525909005133	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
525909005134	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
525909005135	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
525909005136	putative NAD(P) binding site [chemical binding]; other site
525909005137	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
525909005138	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
525909005139	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
525909005140	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
525909005141	D-pathway; other site
525909005142	Putative ubiquinol binding site [chemical binding]; other site
525909005143	Low-spin heme (heme b) binding site [chemical binding]; other site
525909005144	Putative water exit pathway; other site
525909005145	Binuclear center (heme o3/CuB) [ion binding]; other site
525909005146	K-pathway; other site
525909005147	Putative proton exit pathway; other site
525909005148	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
525909005149	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
525909005150	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
525909005151	heme bH binding site [chemical binding]; other site
525909005152	intrachain domain interface; other site
525909005153	heme bL binding site [chemical binding]; other site
525909005154	interchain domain interface [polypeptide binding]; other site
525909005155	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
525909005156	Qo binding site; other site
525909005157	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
525909005158	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
525909005159	iron-sulfur cluster [ion binding]; other site
525909005160	[2Fe-2S] cluster binding site [ion binding]; other site
525909005161	Cytochrome c; Region: Cytochrom_C; pfam00034
525909005162	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
525909005163	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
525909005164	Subunit I/III interface [polypeptide binding]; other site
525909005165	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
525909005166	Part of AAA domain; Region: AAA_19; pfam13245
525909005167	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
525909005168	substrate binding site [chemical binding]; other site
525909005169	active site
525909005170	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
525909005171	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
525909005172	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
525909005173	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
525909005174	putative dimer interface [polypeptide binding]; other site
525909005175	active site pocket [active]
525909005176	putative cataytic base [active]
525909005177	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
525909005178	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
525909005179	active site
525909005180	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
525909005181	catalytic triad [active]
525909005182	dimer interface [polypeptide binding]; other site
525909005183	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
525909005184	Citrate synthase; Region: Citrate_synt; pfam00285
525909005185	oxalacetate binding site [chemical binding]; other site
525909005186	citrylCoA binding site [chemical binding]; other site
525909005187	coenzyme A binding site [chemical binding]; other site
525909005188	catalytic triad [active]
525909005189	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
525909005190	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
525909005191	Coenzyme A binding pocket [chemical binding]; other site
525909005192	PAC2 family; Region: PAC2; pfam09754
525909005193	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
525909005194	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
525909005195	nudix motif; other site
525909005196	NIL domain; Region: NIL; pfam09383
525909005197	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
525909005198	Ligand Binding Site [chemical binding]; other site
525909005199	TIGR00268 family protein; Region: TIGR00268
525909005200	Transposase domain (DUF772); Region: DUF772; pfam05598
525909005201	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
525909005202	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
525909005203	Chlorite dismutase; Region: Chlor_dismutase; cl01280
525909005204	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909005205	Walker A motif; other site
525909005206	ATP binding site [chemical binding]; other site
525909005207	Walker B motif; other site
525909005208	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
525909005209	Peptidase family M41; Region: Peptidase_M41; pfam01434
525909005210	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
525909005211	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
525909005212	ring oligomerisation interface [polypeptide binding]; other site
525909005213	ATP/Mg binding site [chemical binding]; other site
525909005214	stacking interactions; other site
525909005215	hinge regions; other site
525909005216	Ubiquitin-like proteins; Region: UBQ; cl00155
525909005217	charged pocket; other site
525909005218	hydrophobic patch; other site
525909005219	threonine synthase; Validated; Region: PRK07591
525909005220	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
525909005221	homodimer interface [polypeptide binding]; other site
525909005222	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909005223	catalytic residue [active]
525909005224	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
525909005225	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
525909005226	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
525909005227	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
525909005228	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
525909005229	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
525909005230	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
525909005231	FeS/SAM binding site; other site
525909005232	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
525909005233	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
525909005234	trimer interface [polypeptide binding]; other site
525909005235	dimer interface [polypeptide binding]; other site
525909005236	putative active site [active]
525909005237	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909005238	putative DNA binding site [nucleotide binding]; other site
525909005239	putative Zn2+ binding site [ion binding]; other site
525909005240	arsenical pump membrane protein; Provisional; Region: PRK15445
525909005241	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
525909005242	transmembrane helices; other site
525909005243	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
525909005244	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909005245	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
525909005246	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
525909005247	ThiC family; Region: ThiC; pfam01964
525909005248	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
525909005249	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
525909005250	DNA-binding interface [nucleotide binding]; DNA binding site
525909005251	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909005252	Transposase; Region: HTH_Tnp_1; cl17663
525909005253	transposase/IS protein; Provisional; Region: PRK09183
525909005254	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909005255	Walker A motif; other site
525909005256	ATP binding site [chemical binding]; other site
525909005257	Walker B motif; other site
525909005258	arginine finger; other site
525909005259	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
525909005260	Helix-turn-helix domain; Region: HTH_38; pfam13936
525909005261	Integrase core domain; Region: rve; pfam00665
525909005262	Integrase core domain; Region: rve_3; cl15866
525909005263	Restriction endonuclease XhoI; Region: XhoI; pfam04555
525909005264	PIN domain; Region: PIN_3; cl17397
525909005265	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
525909005266	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
525909005267	dimer interface [polypeptide binding]; other site
525909005268	ssDNA binding site [nucleotide binding]; other site
525909005269	tetramer (dimer of dimers) interface [polypeptide binding]; other site
525909005270	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
525909005271	Uncharacterized conserved protein [Function unknown]; Region: COG1615
525909005272	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
525909005273	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
525909005274	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
525909005275	active site
525909005276	Zn2+ binding site [ion binding]; other site
525909005277	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
525909005278	Transcriptional regulators [Transcription]; Region: MarR; COG1846
525909005279	MarR family; Region: MarR_2; cl17246
525909005280	ABC-2 type transporter; Region: ABC2_membrane; cl17235
525909005281	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
525909005282	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909005283	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
525909005284	Walker A/P-loop; other site
525909005285	ATP binding site [chemical binding]; other site
525909005286	Q-loop/lid; other site
525909005287	ABC transporter signature motif; other site
525909005288	Walker B; other site
525909005289	D-loop; other site
525909005290	H-loop/switch region; other site
525909005291	malate dehydrogenase; Provisional; Region: PRK05442
525909005292	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
525909005293	NAD(P) binding site [chemical binding]; other site
525909005294	dimer interface [polypeptide binding]; other site
525909005295	malate binding site [chemical binding]; other site
525909005296	isocitrate dehydrogenase; Validated; Region: PRK07362
525909005297	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
525909005298	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
525909005299	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399
525909005300	MoaE homodimer interface [polypeptide binding]; other site
525909005301	MoaD interaction [polypeptide binding]; other site
525909005302	active site residues [active]
525909005303	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
525909005304	rod shape-determining protein MreB; Provisional; Region: PRK13930
525909005305	nucleotide binding site [chemical binding]; other site
525909005306	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
525909005307	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
525909005308	SIR2-like domain; Region: SIR2_2; pfam13289
525909005309	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909005310	Transposase; Region: HTH_Tnp_1; cl17663
525909005311	HEAT repeats; Region: HEAT_2; pfam13646
525909005312	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
525909005313	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
525909005314	Na binding site [ion binding]; other site
525909005315	Predicted amidohydrolase [General function prediction only]; Region: COG0388
525909005316	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
525909005317	active site
525909005318	catalytic triad [active]
525909005319	dimer interface [polypeptide binding]; other site
525909005320	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
525909005321	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
525909005322	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
525909005323	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
525909005324	substrate binding site; other site
525909005325	dimer interface; other site
525909005326	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030
525909005327	homotrimer interaction site [polypeptide binding]; other site
525909005328	zinc binding site [ion binding]; other site
525909005329	CDP-binding sites; other site
525909005330	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
525909005331	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
525909005332	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
525909005333	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
525909005334	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
525909005335	Clp amino terminal domain; Region: Clp_N; pfam02861
525909005336	Clp amino terminal domain; Region: Clp_N; pfam02861
525909005337	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909005338	Walker A motif; other site
525909005339	ATP binding site [chemical binding]; other site
525909005340	Walker B motif; other site
525909005341	arginine finger; other site
525909005342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909005343	Walker A motif; other site
525909005344	ATP binding site [chemical binding]; other site
525909005345	Walker B motif; other site
525909005346	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
525909005347	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
525909005348	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
525909005349	substrate binding pocket [chemical binding]; other site
525909005350	chain length determination region; other site
525909005351	substrate-Mg2+ binding site; other site
525909005352	catalytic residues [active]
525909005353	aspartate-rich region 1; other site
525909005354	active site lid residues [active]
525909005355	aspartate-rich region 2; other site
525909005356	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
525909005357	dimer interface [polypeptide binding]; other site
525909005358	putative anticodon binding site; other site
525909005359	tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152
525909005360	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
525909005361	motif 1; other site
525909005362	dimer interface [polypeptide binding]; other site
525909005363	active site
525909005364	motif 2; other site
525909005365	motif 3; other site
525909005366	Type III pantothenate kinase; Region: Pan_kinase; cl17198
525909005367	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
525909005368	pantoate--beta-alanine ligase; Region: panC; TIGR00018
525909005369	active site
525909005370	nucleotide binding site [chemical binding]; other site
525909005371	HIGH motif; other site
525909005372	KMSKS motif; other site
525909005373	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
525909005374	catalytic center binding site [active]
525909005375	ATP binding site [chemical binding]; other site
525909005376	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
525909005377	active site
525909005378	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
525909005379	dihydropteroate synthase; Region: DHPS; TIGR01496
525909005380	substrate binding pocket [chemical binding]; other site
525909005381	dimer interface [polypeptide binding]; other site
525909005382	inhibitor binding site; inhibition site
525909005383	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
525909005384	active site
525909005385	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
525909005386	active site
525909005387	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
525909005388	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
525909005389	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
525909005390	Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183
525909005391	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
525909005392	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
525909005393	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
525909005394	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
525909005395	DNA binding residues [nucleotide binding]
525909005396	thymidylate kinase; Validated; Region: tmk; PRK00698
525909005397	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
525909005398	TMP-binding site; other site
525909005399	ATP-binding site [chemical binding]; other site
525909005400	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
525909005401	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
525909005402	active site
525909005403	interdomain interaction site; other site
525909005404	putative metal-binding site [ion binding]; other site
525909005405	nucleotide binding site [chemical binding]; other site
525909005406	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
525909005407	domain I; other site
525909005408	phosphate binding site [ion binding]; other site
525909005409	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
525909005410	domain II; other site
525909005411	domain III; other site
525909005412	nucleotide binding site [chemical binding]; other site
525909005413	DNA binding groove [nucleotide binding]
525909005414	catalytic site [active]
525909005415	domain IV; other site
525909005416	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
525909005417	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
525909005418	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
525909005419	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
525909005420	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
525909005421	generic binding surface II; other site
525909005422	ssDNA binding site; other site
525909005423	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
525909005424	TrkA-N domain; Region: TrkA_N; pfam02254
525909005425	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
525909005426	TrkA-N domain; Region: TrkA_N; pfam02254
525909005427	TrkA-C domain; Region: TrkA_C; pfam02080
525909005428	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
525909005429	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
525909005430	motif II; other site
525909005431	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
525909005432	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
525909005433	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
525909005434	putative active site [active]
525909005435	metal binding site [ion binding]; metal-binding site
525909005436	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
525909005437	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
525909005438	non-specific DNA binding site [nucleotide binding]; other site
525909005439	salt bridge; other site
525909005440	sequence-specific DNA binding site [nucleotide binding]; other site
525909005441	PBP superfamily domain; Region: PBP_like; pfam12727
525909005442	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
525909005443	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909005444	Walker A/P-loop; other site
525909005445	ATP binding site [chemical binding]; other site
525909005446	Q-loop/lid; other site
525909005447	ABC transporter signature motif; other site
525909005448	Walker B; other site
525909005449	D-loop; other site
525909005450	H-loop/switch region; other site
525909005451	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
525909005452	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
525909005453	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
525909005454	aminotransferase; Validated; Region: PRK07777
525909005455	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
525909005456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
525909005457	homodimer interface [polypeptide binding]; other site
525909005458	catalytic residue [active]
525909005459	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
525909005460	S-adenosylmethionine binding site [chemical binding]; other site
525909005461	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
525909005462	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
525909005463	active site
525909005464	metal binding site [ion binding]; metal-binding site
525909005465	DNA binding site [nucleotide binding]
525909005466	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909005467	AAA domain; Region: AAA_23; pfam13476
525909005468	Walker A/P-loop; other site
525909005469	ATP binding site [chemical binding]; other site
525909005470	Q-loop/lid; other site
525909005471	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909005472	putative Zn2+ binding site [ion binding]; other site
525909005473	putative DNA binding site [nucleotide binding]; other site
525909005474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
525909005475	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
525909005476	NAD(P) binding site [chemical binding]; other site
525909005477	active site
525909005478	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
525909005479	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
525909005480	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
525909005481	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
525909005482	active site
525909005483	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
525909005484	PHP-associated; Region: PHP_C; pfam13263
525909005485	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
525909005486	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
525909005487	active site
525909005488	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
525909005489	active site
525909005490	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
525909005491	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
525909005492	dimerization interface [polypeptide binding]; other site
525909005493	putative ATP binding site [chemical binding]; other site
525909005494	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
525909005495	active site
525909005496	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
525909005497	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
525909005498	Malic enzyme, N-terminal domain; Region: malic; pfam00390
525909005499	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
525909005500	putative NAD(P) binding site [chemical binding]; other site
525909005501	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
525909005502	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
525909005503	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
525909005504	active site
525909005505	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
525909005506	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
525909005507	dimerization interface [polypeptide binding]; other site
525909005508	ATP binding site [chemical binding]; other site
525909005509	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
525909005510	dimerization interface [polypeptide binding]; other site
525909005511	ATP binding site [chemical binding]; other site
525909005512	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
525909005513	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
525909005514	putative active site [active]
525909005515	catalytic triad [active]
525909005516	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component [Nucleotide transport and metabolism]; Region: PurS; COG1828
525909005517	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
525909005518	active site
525909005519	ATP binding site [chemical binding]; other site
525909005520	substrate binding site [chemical binding]; other site
525909005521	adenylosuccinate lyase; Provisional; Region: PRK07492
525909005522	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
525909005523	tetramer interface [polypeptide binding]; other site
525909005524	active site
525909005525	Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397
525909005526	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
525909005527	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
525909005528	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
525909005529	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
525909005530	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
525909005531	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
525909005532	GDP-binding site [chemical binding]; other site
525909005533	ACT binding site; other site
525909005534	IMP binding site; other site
525909005535	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
525909005536	catalytic core [active]
525909005537	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
525909005538	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
525909005539	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
525909005540	nucleotide binding site [chemical binding]; other site
525909005541	NEF interaction site [polypeptide binding]; other site
525909005542	SBD interface [polypeptide binding]; other site
525909005543	GrpE; Region: GrpE; pfam01025
525909005544	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
525909005545	dimer interface [polypeptide binding]; other site
525909005546	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
525909005547	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
525909005548	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
525909005549	HSP70 interaction site [polypeptide binding]; other site
525909005550	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
525909005551	Zn binding sites [ion binding]; other site
525909005552	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
525909005553	dimer interface [polypeptide binding]; other site
525909005554	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
525909005555	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
525909005556	DNA binding residues [nucleotide binding]
525909005557	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
525909005558	Clp amino terminal domain; Region: Clp_N; pfam02861
525909005559	Clp amino terminal domain; Region: Clp_N; pfam02861
525909005560	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909005561	Walker A motif; other site
525909005562	ATP binding site [chemical binding]; other site
525909005563	Walker B motif; other site
525909005564	arginine finger; other site
525909005565	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
525909005566	Walker A motif; other site
525909005567	ATP binding site [chemical binding]; other site
525909005568	Walker B motif; other site
525909005569	arginine finger; other site
525909005570	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
525909005571	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
525909005572	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
525909005573	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
525909005574	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
525909005575	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
525909005576	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
525909005577	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
525909005578	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
525909005579	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
525909005580	Methyltransferase domain; Region: Methyltransf_24; pfam13578
525909005581	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
525909005582	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
525909005583	Probable Catalytic site; other site
525909005584	metal-binding site
525909005585	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
525909005586	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
525909005587	active site
525909005588	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
525909005589	Transposase; Region: HTH_Tnp_1; pfam01527
525909005590	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
525909005591	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
525909005592	active site
525909005593	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
525909005594	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
525909005595	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
525909005596	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
525909005597	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
525909005598	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
525909005599	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
525909005600	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
525909005601	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
525909005602	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
525909005603	ligand binding site [chemical binding]; other site
525909005604	homodimer interface [polypeptide binding]; other site
525909005605	NAD(P) binding site [chemical binding]; other site
525909005606	trimer interface B [polypeptide binding]; other site
525909005607	trimer interface A [polypeptide binding]; other site
525909005608	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
525909005609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
525909005610	active site
525909005611	phosphorylation site [posttranslational modification]
525909005612	intermolecular recognition site; other site
525909005613	dimerization interface [polypeptide binding]; other site
525909005614	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
525909005615	DNA binding residues [nucleotide binding]
525909005616	dimerization interface [polypeptide binding]; other site
525909005617	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
525909005618	aminotransferase; Validated; Region: PRK07046
525909005619	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
525909005620	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
525909005621	catalytic residue [active]
525909005622	isocitrate dehydrogenase; Validated; Region: PRK09222
525909005623	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
525909005624	Transcriptional regulators [Transcription]; Region: MarR; COG1846
525909005625	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
525909005626	putative Zn2+ binding site [ion binding]; other site
525909005627	putative DNA binding site [nucleotide binding]; other site
525909005628	Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426
525909005629	polypeptide substrate binding site [polypeptide binding]; other site
525909005630	active site
525909005631	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
525909005632	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
525909005633	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
525909005634	active site
525909005635	dimer interface [polypeptide binding]; other site
525909005636	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
525909005637	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
525909005638	active site
525909005639	FMN binding site [chemical binding]; other site
525909005640	substrate binding site [chemical binding]; other site
525909005641	3Fe-4S cluster binding site [ion binding]; other site
525909005642	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
525909005643	domain interface; other site
525909005644	Colicin V production protein; Region: Colicin_V; pfam02674
525909005645	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
525909005646	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
525909005647	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
525909005648	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
525909005649	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
525909005650	metal binding site [ion binding]; metal-binding site
525909005651	dimer interface [polypeptide binding]; other site
525909005652	RmuC family; Region: RmuC; pfam02646
525909005653	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
525909005654	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
525909005655	active site residue [active]
525909005656	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
525909005657	active site residue [active]
525909005658	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
525909005659	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
525909005660	active site residue [active]
525909005661	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
525909005662	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
525909005663	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552
525909005664	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
525909005665	FAD binding domain; Region: FAD_binding_4; pfam01565
525909005666	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
525909005667	Cysteine-rich domain; Region: CCG; pfam02754
525909005668	Cysteine-rich domain; Region: CCG; pfam02754
525909005669	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
525909005670	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
525909005671	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
525909005672	active site
525909005673	CBD_II domain; Region: CBD_II; smart00637
525909005674	CBD_II domain; Region: CBD_II; smart00637
525909005675	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl09839
525909005676	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
525909005677	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
525909005678	DNA binding residues [nucleotide binding]
525909005679	dimer interface [polypeptide binding]; other site
525909005680	metal binding site [ion binding]; metal-binding site
525909005681	mercuric reductase; Region: MerA; TIGR02053
525909005682	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
525909005683	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
525909005684	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
525909005685	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792
525909005686	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
525909005687	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
525909005688	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
525909005689	HTH-like domain; Region: HTH_21; pfam13276
525909005690	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
525909005691	Integrase core domain; Region: rve; pfam00665
525909005692	Integrase core domain; Region: rve_3; pfam13683
525909005693	Transposase; Region: HTH_Tnp_1; pfam01527
525909005694	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
525909005695	oligomeric interface; other site
525909005696	putative active site [active]
525909005697	homodimer interface [polypeptide binding]; other site
525909005698	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
525909005699	Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590
525909005700	active site
525909005701	Zn binding site [ion binding]; other site
525909005702	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
525909005703	Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673
525909005704	dimer interface [polypeptide binding]; other site
525909005705	tetramer interface [polypeptide binding]; other site
525909005706	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
525909005707	active site
525909005708	metal binding site [ion binding]; metal-binding site
525909005709	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
525909005710	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
525909005711	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
525909005712	active site
525909005713	citrylCoA binding site [chemical binding]; other site
525909005714	oxalacetate binding site [chemical binding]; other site
525909005715	coenzyme A binding site [chemical binding]; other site
525909005716	catalytic triad [active]
525909005717	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
525909005718	CoA-transferase family III; Region: CoA_transf_3; pfam02515
525909005719	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
525909005720	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
525909005721	Bacterial transcriptional regulator; Region: IclR; pfam01614
525909005722	hypothetical protein; Provisional; Region: PRK08204
525909005723	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
525909005724	active site
525909005725	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
525909005726	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
525909005727	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
525909005728	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
525909005729	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
525909005730	Walker A/P-loop; other site
525909005731	ATP binding site [chemical binding]; other site
525909005732	Q-loop/lid; other site
525909005733	ABC transporter signature motif; other site
525909005734	Walker B; other site
525909005735	D-loop; other site
525909005736	H-loop/switch region; other site
525909005737	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
525909005738	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
525909005739	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
525909005740	Walker A/P-loop; other site
525909005741	ATP binding site [chemical binding]; other site
525909005742	Q-loop/lid; other site
525909005743	ABC transporter signature motif; other site
525909005744	Walker B; other site
525909005745	D-loop; other site
525909005746	H-loop/switch region; other site
525909005747	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
525909005748	ParB-like nuclease domain; Region: ParB; smart00470
525909005749	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
525909005750	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
525909005751	P-loop; other site
525909005752	Magnesium ion binding site [ion binding]; other site
525909005753	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
525909005754	Magnesium ion binding site [ion binding]; other site
525909005755	Transposase domain (DUF772); Region: DUF772; pfam05598
525909005756	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
525909005757	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
525909005758	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
525909005759	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
525909005760	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
525909005761	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
525909005762	G-X-X-G motif; other site
525909005763	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
525909005764	RxxxH motif; other site
525909005765	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
525909005766	Uncharacterized conserved protein [Function unknown]; Region: COG0759
525909005767	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399