-- dump date 20140618_184016 -- class Genbank::misc_feature -- table misc_feature_note -- id note 931626000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 931626000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 931626000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626000004 Walker A motif; other site 931626000005 ATP binding site [chemical binding]; other site 931626000006 Walker B motif; other site 931626000007 arginine finger; other site 931626000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 931626000009 DnaA box-binding interface [nucleotide binding]; other site 931626000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 931626000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 931626000012 putative DNA binding surface [nucleotide binding]; other site 931626000013 dimer interface [polypeptide binding]; other site 931626000014 beta-clamp/clamp loader binding surface; other site 931626000015 beta-clamp/translesion DNA polymerase binding surface; other site 931626000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931626000017 RNA binding surface [nucleotide binding]; other site 931626000018 recombination protein F; Reviewed; Region: recF; PRK00064 931626000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626000020 Walker A/P-loop; other site 931626000021 ATP binding site [chemical binding]; other site 931626000022 Q-loop/lid; other site 931626000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626000024 ABC transporter signature motif; other site 931626000025 Walker B; other site 931626000026 D-loop; other site 931626000027 H-loop/switch region; other site 931626000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 931626000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626000030 Mg2+ binding site [ion binding]; other site 931626000031 G-X-G motif; other site 931626000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 931626000033 anchoring element; other site 931626000034 dimer interface [polypeptide binding]; other site 931626000035 ATP binding site [chemical binding]; other site 931626000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 931626000037 active site 931626000038 putative metal-binding site [ion binding]; other site 931626000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 931626000040 DNA gyrase subunit A; Validated; Region: PRK05560 931626000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 931626000042 CAP-like domain; other site 931626000043 active site 931626000044 primary dimer interface [polypeptide binding]; other site 931626000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931626000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931626000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931626000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931626000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931626000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 931626000051 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 931626000052 active site 931626000053 phosphorylation site [posttranslational modification] 931626000054 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 931626000055 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 931626000056 substrate binding site [chemical binding]; other site 931626000057 hexamer interface [polypeptide binding]; other site 931626000058 metal binding site [ion binding]; metal-binding site 931626000059 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 931626000060 active site 931626000061 P-loop; other site 931626000062 phosphorylation site [posttranslational modification] 931626000063 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626000064 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142 931626000065 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cd00316 931626000066 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931626000067 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931626000068 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931626000069 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 931626000070 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 931626000071 intersubunit interface [polypeptide binding]; other site 931626000072 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 931626000073 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931626000074 ABC-ATPase subunit interface; other site 931626000075 dimer interface [polypeptide binding]; other site 931626000076 putative PBP binding regions; other site 931626000077 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 931626000078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626000079 Walker A/P-loop; other site 931626000080 ATP binding site [chemical binding]; other site 931626000081 Q-loop/lid; other site 931626000082 ABC transporter signature motif; other site 931626000083 Walker B; other site 931626000084 D-loop; other site 931626000085 H-loop/switch region; other site 931626000086 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931626000087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626000088 DNA methylase; Region: N6_N4_Mtase; cl17433 931626000089 MarR family; Region: MarR_2; pfam12802 931626000090 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931626000091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626000092 S-adenosylmethionine binding site [chemical binding]; other site 931626000093 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 931626000094 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 931626000095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626000096 dimer interface [polypeptide binding]; other site 931626000097 conserved gate region; other site 931626000098 putative PBP binding loops; other site 931626000099 ABC-ATPase subunit interface; other site 931626000100 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 931626000101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626000102 dimer interface [polypeptide binding]; other site 931626000103 conserved gate region; other site 931626000104 putative PBP binding loops; other site 931626000105 ABC-ATPase subunit interface; other site 931626000106 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 931626000107 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 931626000108 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 931626000109 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931626000110 Walker A/P-loop; other site 931626000111 ATP binding site [chemical binding]; other site 931626000112 Q-loop/lid; other site 931626000113 ABC transporter signature motif; other site 931626000114 Walker B; other site 931626000115 D-loop; other site 931626000116 H-loop/switch region; other site 931626000117 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 931626000118 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 931626000119 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931626000120 Walker A/P-loop; other site 931626000121 ATP binding site [chemical binding]; other site 931626000122 Q-loop/lid; other site 931626000123 ABC transporter signature motif; other site 931626000124 Walker B; other site 931626000125 D-loop; other site 931626000126 H-loop/switch region; other site 931626000127 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 931626000128 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931626000129 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 931626000130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626000131 S-adenosylmethionine binding site [chemical binding]; other site 931626000132 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 931626000133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626000134 dimer interface [polypeptide binding]; other site 931626000135 conserved gate region; other site 931626000136 putative PBP binding loops; other site 931626000137 ABC-ATPase subunit interface; other site 931626000138 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 931626000139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626000140 dimer interface [polypeptide binding]; other site 931626000141 conserved gate region; other site 931626000142 putative PBP binding loops; other site 931626000143 ABC-ATPase subunit interface; other site 931626000144 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 931626000145 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 931626000146 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 931626000147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931626000148 Walker A/P-loop; other site 931626000149 ATP binding site [chemical binding]; other site 931626000150 Q-loop/lid; other site 931626000151 ABC transporter signature motif; other site 931626000152 Walker B; other site 931626000153 D-loop; other site 931626000154 H-loop/switch region; other site 931626000155 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 931626000156 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 931626000157 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931626000158 Walker A/P-loop; other site 931626000159 ATP binding site [chemical binding]; other site 931626000160 Q-loop/lid; other site 931626000161 ABC transporter signature motif; other site 931626000162 Walker B; other site 931626000163 D-loop; other site 931626000164 H-loop/switch region; other site 931626000165 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 931626000166 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931626000167 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 931626000168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626000169 S-adenosylmethionine binding site [chemical binding]; other site 931626000170 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 931626000171 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 931626000172 putative homodimer interface [polypeptide binding]; other site 931626000173 putative homotetramer interface [polypeptide binding]; other site 931626000174 putative metal binding site [ion binding]; other site 931626000175 putative homodimer-homodimer interface [polypeptide binding]; other site 931626000176 putative allosteric switch controlling residues; other site 931626000177 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 931626000178 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 931626000179 active site 931626000180 Zn binding site [ion binding]; other site 931626000181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626000182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626000183 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 931626000184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626000185 dimer interface [polypeptide binding]; other site 931626000186 conserved gate region; other site 931626000187 ABC-ATPase subunit interface; other site 931626000188 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 931626000189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626000190 dimer interface [polypeptide binding]; other site 931626000191 conserved gate region; other site 931626000192 putative PBP binding loops; other site 931626000193 ABC-ATPase subunit interface; other site 931626000194 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 931626000195 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 931626000196 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931626000197 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 931626000198 Walker A/P-loop; other site 931626000199 ATP binding site [chemical binding]; other site 931626000200 Q-loop/lid; other site 931626000201 ABC transporter signature motif; other site 931626000202 Walker B; other site 931626000203 D-loop; other site 931626000204 H-loop/switch region; other site 931626000205 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 931626000206 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931626000207 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 931626000208 Walker A/P-loop; other site 931626000209 ATP binding site [chemical binding]; other site 931626000210 Q-loop/lid; other site 931626000211 ABC transporter signature motif; other site 931626000212 Walker B; other site 931626000213 D-loop; other site 931626000214 H-loop/switch region; other site 931626000215 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 931626000216 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 931626000217 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 931626000218 substrate binding site [chemical binding]; other site 931626000219 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 931626000220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626000221 dimer interface [polypeptide binding]; other site 931626000222 conserved gate region; other site 931626000223 putative PBP binding loops; other site 931626000224 ABC-ATPase subunit interface; other site 931626000225 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 931626000226 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 931626000227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626000228 dimer interface [polypeptide binding]; other site 931626000229 conserved gate region; other site 931626000230 putative PBP binding loops; other site 931626000231 ABC-ATPase subunit interface; other site 931626000232 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931626000233 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 931626000234 Walker A/P-loop; other site 931626000235 ATP binding site [chemical binding]; other site 931626000236 Q-loop/lid; other site 931626000237 ABC transporter signature motif; other site 931626000238 Walker B; other site 931626000239 D-loop; other site 931626000240 H-loop/switch region; other site 931626000241 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 931626000242 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 931626000243 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931626000244 Walker A/P-loop; other site 931626000245 ATP binding site [chemical binding]; other site 931626000246 Q-loop/lid; other site 931626000247 ABC transporter signature motif; other site 931626000248 Walker B; other site 931626000249 D-loop; other site 931626000250 H-loop/switch region; other site 931626000251 Predicted membrane protein [Function unknown]; Region: COG2119 931626000252 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 931626000253 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 931626000254 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 931626000255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626000256 active site 931626000257 motif I; other site 931626000258 motif II; other site 931626000259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626000260 motif II; other site 931626000261 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 931626000262 ThiS interaction site; other site 931626000263 putative active site [active] 931626000264 tetramer interface [polypeptide binding]; other site 931626000265 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 931626000266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 931626000267 FeS/SAM binding site; other site 931626000268 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 931626000269 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 931626000270 thiamine phosphate binding site [chemical binding]; other site 931626000271 active site 931626000272 pyrophosphate binding site [ion binding]; other site 931626000273 Cache domain; Region: Cache_1; pfam02743 931626000274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626000275 dimerization interface [polypeptide binding]; other site 931626000276 PAS domain; Region: PAS_9; pfam13426 931626000277 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626000278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626000279 metal binding site [ion binding]; metal-binding site 931626000280 active site 931626000281 I-site; other site 931626000282 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626000283 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 931626000284 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 931626000285 catalytic motif [active] 931626000286 Zn binding site [ion binding]; other site 931626000287 RibD C-terminal domain; Region: RibD_C; cl17279 931626000288 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 931626000289 Lumazine binding domain; Region: Lum_binding; pfam00677 931626000290 Lumazine binding domain; Region: Lum_binding; pfam00677 931626000291 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 931626000292 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 931626000293 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 931626000294 dimerization interface [polypeptide binding]; other site 931626000295 active site 931626000296 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 931626000297 homopentamer interface [polypeptide binding]; other site 931626000298 active site 931626000299 LytTr DNA-binding domain; Region: LytTR; smart00850 931626000300 Protein of unknown function (DUF975); Region: DUF975; cl10504 931626000301 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 931626000302 Zn binding site [ion binding]; other site 931626000303 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 931626000304 dipeptidase PepV; Reviewed; Region: PRK07318 931626000305 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 931626000306 active site 931626000307 metal binding site [ion binding]; metal-binding site 931626000308 dipeptidase PepV; Reviewed; Region: PRK07318 931626000309 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 931626000310 active site 931626000311 metal binding site [ion binding]; metal-binding site 931626000312 Biotin operon repressor [Transcription]; Region: BirA; COG1654 931626000313 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 931626000314 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 931626000315 BioY family; Region: BioY; pfam02632 931626000316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626000317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626000318 dimer interface [polypeptide binding]; other site 931626000319 phosphorylation site [posttranslational modification] 931626000320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626000321 ATP binding site [chemical binding]; other site 931626000322 Mg2+ binding site [ion binding]; other site 931626000323 G-X-G motif; other site 931626000324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626000325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626000326 active site 931626000327 phosphorylation site [posttranslational modification] 931626000328 intermolecular recognition site; other site 931626000329 dimerization interface [polypeptide binding]; other site 931626000330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626000331 DNA binding site [nucleotide binding] 931626000332 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626000333 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 931626000334 Walker A/P-loop; other site 931626000335 ATP binding site [chemical binding]; other site 931626000336 Q-loop/lid; other site 931626000337 ABC transporter signature motif; other site 931626000338 Walker B; other site 931626000339 D-loop; other site 931626000340 H-loop/switch region; other site 931626000341 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 931626000342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 931626000343 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 931626000344 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931626000345 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 931626000346 putative active site [active] 931626000347 metal binding site [ion binding]; metal-binding site 931626000348 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 931626000349 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 931626000350 ArsC family; Region: ArsC; pfam03960 931626000351 putative ArsC-like catalytic residues; other site 931626000352 putative TRX-like catalytic residues [active] 931626000353 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 931626000354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626000355 FeS/SAM binding site; other site 931626000356 UPF0489 domain; Region: UPF0489; pfam12640 931626000357 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 931626000358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626000359 active site 931626000360 phosphorylation site [posttranslational modification] 931626000361 intermolecular recognition site; other site 931626000362 dimerization interface [polypeptide binding]; other site 931626000363 LytTr DNA-binding domain; Region: LytTR; smart00850 931626000364 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 931626000365 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 931626000366 Pirin-related protein [General function prediction only]; Region: COG1741 931626000367 Pirin; Region: Pirin; pfam02678 931626000368 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 931626000369 Clostridial hydrophobic W; Region: ChW; pfam07538 931626000370 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626000371 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626000372 Clostridial hydrophobic W; Region: ChW; pfam07538 931626000373 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 931626000374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626000375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931626000376 putative substrate translocation pore; other site 931626000377 QueT transporter; Region: QueT; pfam06177 931626000378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 931626000379 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 931626000380 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 931626000381 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 931626000382 dimer interface [polypeptide binding]; other site 931626000383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626000384 catalytic residue [active] 931626000385 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 931626000386 active site 931626000387 dimer interfaces [polypeptide binding]; other site 931626000388 catalytic residues [active] 931626000389 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 931626000390 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931626000391 ABC-ATPase subunit interface; other site 931626000392 dimer interface [polypeptide binding]; other site 931626000393 putative PBP binding regions; other site 931626000394 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 931626000395 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 931626000396 Walker A/P-loop; other site 931626000397 ATP binding site [chemical binding]; other site 931626000398 Q-loop/lid; other site 931626000399 ABC transporter signature motif; other site 931626000400 Walker B; other site 931626000401 D-loop; other site 931626000402 H-loop/switch region; other site 931626000403 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 931626000404 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 931626000405 intersubunit interface [polypeptide binding]; other site 931626000406 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626000407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626000408 Walker A/P-loop; other site 931626000409 ATP binding site [chemical binding]; other site 931626000410 Q-loop/lid; other site 931626000411 ABC transporter signature motif; other site 931626000412 Walker B; other site 931626000413 H-loop/switch region; other site 931626000414 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378 931626000415 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931626000416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626000417 S-adenosylmethionine binding site [chemical binding]; other site 931626000418 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931626000419 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 931626000420 Uncharacterized conserved protein [Function unknown]; Region: COG0398 931626000421 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 931626000422 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 931626000423 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 931626000424 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 931626000425 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931626000426 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931626000427 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931626000428 putative active site [active] 931626000429 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 931626000430 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 931626000431 putative NAD(P) binding site [chemical binding]; other site 931626000432 catalytic Zn binding site [ion binding]; other site 931626000433 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 931626000434 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931626000435 nucleotide binding site [chemical binding]; other site 931626000436 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 931626000437 intersubunit interface [polypeptide binding]; other site 931626000438 active site 931626000439 catalytic residue [active] 931626000440 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 931626000441 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 931626000442 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626000443 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626000444 Walker A/P-loop; other site 931626000445 ATP binding site [chemical binding]; other site 931626000446 Q-loop/lid; other site 931626000447 ABC transporter signature motif; other site 931626000448 Walker B; other site 931626000449 D-loop; other site 931626000450 H-loop/switch region; other site 931626000451 PAS fold; Region: PAS_4; pfam08448 931626000452 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 931626000453 GAF domain; Region: GAF_2; pfam13185 931626000454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626000455 PAS domain; Region: PAS_9; pfam13426 931626000456 putative active site [active] 931626000457 heme pocket [chemical binding]; other site 931626000458 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626000459 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626000460 metal binding site [ion binding]; metal-binding site 931626000461 active site 931626000462 I-site; other site 931626000463 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626000464 Zn2+ binding site [ion binding]; other site 931626000465 Mg2+ binding site [ion binding]; other site 931626000466 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626000467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626000468 dimer interface [polypeptide binding]; other site 931626000469 phosphorylation site [posttranslational modification] 931626000470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626000471 ATP binding site [chemical binding]; other site 931626000472 Mg2+ binding site [ion binding]; other site 931626000473 G-X-G motif; other site 931626000474 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626000475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626000476 active site 931626000477 phosphorylation site [posttranslational modification] 931626000478 intermolecular recognition site; other site 931626000479 dimerization interface [polypeptide binding]; other site 931626000480 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626000481 DNA binding site [nucleotide binding] 931626000482 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 931626000483 putative metal binding residues [ion binding]; other site 931626000484 signature motif; other site 931626000485 dimer interface [polypeptide binding]; other site 931626000486 active site 931626000487 polyP binding site; other site 931626000488 substrate binding site [chemical binding]; other site 931626000489 acceptor-phosphate pocket; other site 931626000490 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 931626000491 CotH protein; Region: CotH; pfam08757 931626000492 CotH protein; Region: CotH; pfam08757 931626000493 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931626000494 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626000495 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626000496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626000497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626000498 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 931626000499 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626000500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626000501 active site 931626000502 phosphorylation site [posttranslational modification] 931626000503 intermolecular recognition site; other site 931626000504 dimerization interface [polypeptide binding]; other site 931626000505 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626000506 DNA binding site [nucleotide binding] 931626000507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626000508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626000509 dimer interface [polypeptide binding]; other site 931626000510 phosphorylation site [posttranslational modification] 931626000511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626000512 ATP binding site [chemical binding]; other site 931626000513 Mg2+ binding site [ion binding]; other site 931626000514 G-X-G motif; other site 931626000515 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626000516 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626000517 Walker A/P-loop; other site 931626000518 ATP binding site [chemical binding]; other site 931626000519 Q-loop/lid; other site 931626000520 ABC transporter signature motif; other site 931626000521 Walker B; other site 931626000522 D-loop; other site 931626000523 H-loop/switch region; other site 931626000524 FtsX-like permease family; Region: FtsX; pfam02687 931626000525 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626000526 FtsX-like permease family; Region: FtsX; pfam02687 931626000527 Rrf2 family protein; Region: rrf2_super; TIGR00738 931626000528 Transcriptional regulator; Region: Rrf2; pfam02082 931626000529 Predicted membrane protein [Function unknown]; Region: COG1511 931626000530 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 931626000531 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 931626000532 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 931626000533 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 931626000534 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 931626000535 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 931626000536 active site 931626000537 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 931626000538 Int/Topo IB signature motif; other site 931626000539 Winged helix-turn helix; Region: HTH_29; pfam13551 931626000540 Homeodomain-like domain; Region: HTH_32; pfam13565 931626000541 Integrase core domain; Region: rve; pfam00665 931626000542 Integrase core domain; Region: rve_3; pfam13683 931626000543 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 931626000544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626000545 Walker A motif; other site 931626000546 ATP binding site [chemical binding]; other site 931626000547 Walker B motif; other site 931626000548 arginine finger; other site 931626000549 Helix-turn-helix domain; Region: HTH_17; pfam12728 931626000550 BRO family, N-terminal domain; Region: Bro-N; smart01040 931626000551 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 931626000552 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 931626000553 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 931626000554 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 931626000555 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 931626000556 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 931626000557 catalytic residues [active] 931626000558 catalytic nucleophile [active] 931626000559 Presynaptic Site I dimer interface [polypeptide binding]; other site 931626000560 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 931626000561 Synaptic Flat tetramer interface [polypeptide binding]; other site 931626000562 Synaptic Site I dimer interface [polypeptide binding]; other site 931626000563 DNA binding site [nucleotide binding] 931626000564 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 931626000565 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 931626000566 putative active site [active] 931626000567 putative NTP binding site [chemical binding]; other site 931626000568 putative nucleic acid binding site [nucleotide binding]; other site 931626000569 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 931626000570 Domain of unknown function (DUF955); Region: DUF955; cl01076 931626000571 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 931626000572 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 931626000573 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 931626000574 HSP70 interaction site [polypeptide binding]; other site 931626000575 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 931626000576 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 931626000577 Walker A/P-loop; other site 931626000578 ATP binding site [chemical binding]; other site 931626000579 Q-loop/lid; other site 931626000580 ABC transporter signature motif; other site 931626000581 Walker B; other site 931626000582 D-loop; other site 931626000583 H-loop/switch region; other site 931626000584 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 931626000585 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 931626000586 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 931626000587 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 931626000588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626000589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626000590 active site 931626000591 phosphorylation site [posttranslational modification] 931626000592 intermolecular recognition site; other site 931626000593 dimerization interface [polypeptide binding]; other site 931626000594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626000595 DNA binding site [nucleotide binding] 931626000596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626000597 HAMP domain; Region: HAMP; pfam00672 931626000598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626000599 dimer interface [polypeptide binding]; other site 931626000600 phosphorylation site [posttranslational modification] 931626000601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626000602 ATP binding site [chemical binding]; other site 931626000603 Mg2+ binding site [ion binding]; other site 931626000604 G-X-G motif; other site 931626000605 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626000606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626000607 active site 931626000608 phosphorylation site [posttranslational modification] 931626000609 intermolecular recognition site; other site 931626000610 dimerization interface [polypeptide binding]; other site 931626000611 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626000612 DNA binding site [nucleotide binding] 931626000613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626000614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626000615 dimerization interface [polypeptide binding]; other site 931626000616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626000617 dimer interface [polypeptide binding]; other site 931626000618 phosphorylation site [posttranslational modification] 931626000619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626000620 ATP binding site [chemical binding]; other site 931626000621 Mg2+ binding site [ion binding]; other site 931626000622 G-X-G motif; other site 931626000623 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626000624 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626000625 Walker A/P-loop; other site 931626000626 ATP binding site [chemical binding]; other site 931626000627 Q-loop/lid; other site 931626000628 ABC transporter signature motif; other site 931626000629 Walker B; other site 931626000630 D-loop; other site 931626000631 H-loop/switch region; other site 931626000632 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931626000633 FtsX-like permease family; Region: FtsX; pfam02687 931626000634 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626000635 FtsX-like permease family; Region: FtsX; pfam02687 931626000636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626000637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626000638 Amidohydrolase; Region: Amidohydro_2; pfam04909 931626000639 active site 931626000640 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 931626000641 putative ADP-ribose binding site [chemical binding]; other site 931626000642 putative active site [active] 931626000643 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 931626000644 metal ion-dependent adhesion site (MIDAS); other site 931626000645 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 931626000646 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931626000647 ligand binding site [chemical binding]; other site 931626000648 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 931626000649 putative switch regulator; other site 931626000650 non-specific DNA interactions [nucleotide binding]; other site 931626000651 DNA binding site [nucleotide binding] 931626000652 sequence specific DNA binding site [nucleotide binding]; other site 931626000653 putative cAMP binding site [chemical binding]; other site 931626000654 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626000655 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626000656 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 931626000657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626000658 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626000659 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 931626000660 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 931626000661 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 931626000662 E3 interaction surface; other site 931626000663 lipoyl attachment site [posttranslational modification]; other site 931626000664 e3 binding domain; Region: E3_binding; pfam02817 931626000665 e3 binding domain; Region: E3_binding; pfam02817 931626000666 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 931626000667 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 931626000668 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 931626000669 alpha subunit interface [polypeptide binding]; other site 931626000670 TPP binding site [chemical binding]; other site 931626000671 heterodimer interface [polypeptide binding]; other site 931626000672 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931626000673 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 931626000674 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 931626000675 tetramer interface [polypeptide binding]; other site 931626000676 TPP-binding site [chemical binding]; other site 931626000677 heterodimer interface [polypeptide binding]; other site 931626000678 phosphorylation loop region [posttranslational modification] 931626000679 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 931626000680 GAF domain; Region: GAF; pfam01590 931626000681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626000682 Walker A motif; other site 931626000683 ATP binding site [chemical binding]; other site 931626000684 Walker B motif; other site 931626000685 arginine finger; other site 931626000686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626000687 Coenzyme A binding pocket [chemical binding]; other site 931626000688 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931626000689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626000690 Coenzyme A binding pocket [chemical binding]; other site 931626000691 Cache domain; Region: Cache_1; pfam02743 931626000692 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626000693 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626000694 metal binding site [ion binding]; metal-binding site 931626000695 active site 931626000696 I-site; other site 931626000697 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 931626000698 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 931626000699 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626000700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626000701 metal binding site [ion binding]; metal-binding site 931626000702 active site 931626000703 I-site; other site 931626000704 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626000705 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 931626000706 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 931626000707 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 931626000708 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 931626000709 TIGR02677 family protein; Region: TIGR02677 931626000710 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 931626000711 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 931626000712 TIGR02680 family protein; Region: TIGR02680 931626000713 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 931626000714 TIGR02679 family protein; Region: TIGR02679 931626000715 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 931626000716 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 931626000717 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931626000718 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 931626000719 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 931626000720 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931626000721 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 931626000722 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 931626000723 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 931626000724 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 931626000725 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 931626000726 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 931626000727 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 931626000728 Response regulator receiver domain; Region: Response_reg; pfam00072 931626000729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 931626000730 active site 931626000731 phosphorylation site [posttranslational modification] 931626000732 intermolecular recognition site; other site 931626000733 dimerization interface [polypeptide binding]; other site 931626000734 ANTAR domain; Region: ANTAR; pfam03861 931626000735 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 931626000736 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 931626000737 GDP-binding site [chemical binding]; other site 931626000738 ACT binding site; other site 931626000739 IMP binding site; other site 931626000740 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 931626000741 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 931626000742 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 931626000743 catalytic site [active] 931626000744 subunit interface [polypeptide binding]; other site 931626000745 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 931626000746 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 931626000747 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 931626000748 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 931626000749 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 931626000750 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931626000751 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 931626000752 IMP binding site; other site 931626000753 dimer interface [polypeptide binding]; other site 931626000754 interdomain contacts; other site 931626000755 partial ornithine binding site; other site 931626000756 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 931626000757 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626000758 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626000759 metal binding site [ion binding]; metal-binding site 931626000760 active site 931626000761 I-site; other site 931626000762 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626000763 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 931626000764 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 931626000765 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 931626000766 Walker A motif; other site 931626000767 ATP binding site [chemical binding]; other site 931626000768 Walker B motif; other site 931626000769 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 931626000770 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 931626000771 Walker A motif; other site 931626000772 ATP binding site [chemical binding]; other site 931626000773 Walker B motif; other site 931626000774 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 931626000775 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 931626000776 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 931626000777 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 931626000778 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 931626000779 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 931626000780 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 931626000781 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 931626000782 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 931626000783 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 931626000784 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 931626000785 active site 931626000786 Coronavirus 6B/7B protein; Region: Corona_6B_7B; pfam03262 931626000787 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 931626000788 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 931626000789 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 931626000790 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 931626000791 ATP synthase I chain; Region: ATP_synt_I; pfam03899 931626000792 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 931626000793 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 931626000794 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 931626000795 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 931626000796 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 931626000797 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 931626000798 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 931626000799 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 931626000800 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 931626000801 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 931626000802 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 931626000803 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 931626000804 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 931626000805 beta subunit interaction interface [polypeptide binding]; other site 931626000806 Walker A motif; other site 931626000807 ATP binding site [chemical binding]; other site 931626000808 Walker B motif; other site 931626000809 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 931626000810 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 931626000811 core domain interface [polypeptide binding]; other site 931626000812 delta subunit interface [polypeptide binding]; other site 931626000813 epsilon subunit interface [polypeptide binding]; other site 931626000814 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 931626000815 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 931626000816 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 931626000817 alpha subunit interaction interface [polypeptide binding]; other site 931626000818 Walker A motif; other site 931626000819 ATP binding site [chemical binding]; other site 931626000820 Walker B motif; other site 931626000821 inhibitor binding site; inhibition site 931626000822 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 931626000823 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450 931626000824 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 931626000825 gamma subunit interface [polypeptide binding]; other site 931626000826 epsilon subunit interface [polypeptide binding]; other site 931626000827 LBP interface [polypeptide binding]; other site 931626000828 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 931626000829 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 931626000830 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 931626000831 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 931626000832 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 931626000833 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 931626000834 active site 931626000835 tetramer interface; other site 931626000836 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 931626000837 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 931626000838 active site 931626000839 substrate binding site [chemical binding]; other site 931626000840 metal binding site [ion binding]; metal-binding site 931626000841 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 931626000842 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 931626000843 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 931626000844 NADP binding site [chemical binding]; other site 931626000845 active site 931626000846 putative substrate binding site [chemical binding]; other site 931626000847 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 931626000848 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 931626000849 substrate binding site; other site 931626000850 tetramer interface; other site 931626000851 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 931626000852 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 931626000853 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 931626000854 NAD binding site [chemical binding]; other site 931626000855 substrate binding site [chemical binding]; other site 931626000856 homodimer interface [polypeptide binding]; other site 931626000857 active site 931626000858 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 931626000859 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931626000860 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 931626000861 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 931626000862 Walker A/P-loop; other site 931626000863 ATP binding site [chemical binding]; other site 931626000864 Q-loop/lid; other site 931626000865 ABC transporter signature motif; other site 931626000866 Walker B; other site 931626000867 D-loop; other site 931626000868 H-loop/switch region; other site 931626000869 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 931626000870 putative carbohydrate binding site [chemical binding]; other site 931626000871 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 931626000872 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 931626000873 Probable Catalytic site; other site 931626000874 metal-binding site 931626000875 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 931626000876 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 931626000877 Probable Catalytic site; other site 931626000878 metal-binding site 931626000879 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 931626000880 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 931626000881 active site 931626000882 metal binding site [ion binding]; metal-binding site 931626000883 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626000884 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626000885 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626000886 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626000887 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626000888 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 931626000889 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626000890 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626000891 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626000892 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626000893 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 931626000894 Peptidase family M23; Region: Peptidase_M23; pfam01551 931626000895 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 931626000896 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 931626000897 Probable Catalytic site; other site 931626000898 metal-binding site 931626000899 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 931626000900 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 931626000901 Probable Catalytic site; other site 931626000902 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931626000903 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 931626000904 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 931626000905 NAD binding site [chemical binding]; other site 931626000906 Bacterial sugar transferase; Region: Bac_transf; pfam02397 931626000907 Predicted membrane protein [Function unknown]; Region: COG4713 931626000908 YibE/F-like protein; Region: YibE_F; cl02259 931626000909 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 931626000910 Ligand binding site; other site 931626000911 Putative Catalytic site; other site 931626000912 DXD motif; other site 931626000913 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 931626000914 Ligand binding site; other site 931626000915 Putative Catalytic site; other site 931626000916 DXD motif; other site 931626000917 Transcriptional regulator [Transcription]; Region: LytR; COG1316 931626000918 potential frameshift: common BLAST hit: gi|226307850|ref|YP_002767810.1| glutamine ABC transporter glutamine-binding/permease protein 931626000919 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626000920 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626000921 substrate binding pocket [chemical binding]; other site 931626000922 membrane-bound complex binding site; other site 931626000923 hinge residues; other site 931626000924 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 931626000925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626000926 dimer interface [polypeptide binding]; other site 931626000927 conserved gate region; other site 931626000928 putative PBP binding loops; other site 931626000929 ABC-ATPase subunit interface; other site 931626000930 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931626000931 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931626000932 Walker A/P-loop; other site 931626000933 ATP binding site [chemical binding]; other site 931626000934 Q-loop/lid; other site 931626000935 ABC transporter signature motif; other site 931626000936 Walker B; other site 931626000937 D-loop; other site 931626000938 H-loop/switch region; other site 931626000939 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 931626000940 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 931626000941 DXD motif; other site 931626000942 HlyD family secretion protein; Region: HlyD_3; pfam13437 931626000943 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626000944 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626000945 Walker A/P-loop; other site 931626000946 ATP binding site [chemical binding]; other site 931626000947 Q-loop/lid; other site 931626000948 ABC transporter signature motif; other site 931626000949 Walker B; other site 931626000950 D-loop; other site 931626000951 H-loop/switch region; other site 931626000952 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626000953 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931626000954 FtsX-like permease family; Region: FtsX; pfam02687 931626000955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626000956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626000957 active site 931626000958 phosphorylation site [posttranslational modification] 931626000959 intermolecular recognition site; other site 931626000960 dimerization interface [polypeptide binding]; other site 931626000961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626000962 DNA binding site [nucleotide binding] 931626000963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626000964 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626000965 dimerization interface [polypeptide binding]; other site 931626000966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626000967 dimer interface [polypeptide binding]; other site 931626000968 phosphorylation site [posttranslational modification] 931626000969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626000970 ATP binding site [chemical binding]; other site 931626000971 Mg2+ binding site [ion binding]; other site 931626000972 G-X-G motif; other site 931626000973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626000974 Zn2+ binding site [ion binding]; other site 931626000975 Mg2+ binding site [ion binding]; other site 931626000976 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626000977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626000978 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 931626000979 Walker A/P-loop; other site 931626000980 ATP binding site [chemical binding]; other site 931626000981 Q-loop/lid; other site 931626000982 ABC transporter signature motif; other site 931626000983 Walker B; other site 931626000984 D-loop; other site 931626000985 H-loop/switch region; other site 931626000986 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626000987 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626000988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626000989 Walker A/P-loop; other site 931626000990 ATP binding site [chemical binding]; other site 931626000991 Q-loop/lid; other site 931626000992 ABC transporter signature motif; other site 931626000993 Walker B; other site 931626000994 D-loop; other site 931626000995 H-loop/switch region; other site 931626000996 MarR family; Region: MarR_2; cl17246 931626000997 AzlC protein; Region: AzlC; cl00570 931626000998 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 931626000999 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 931626001000 Predicted transcriptional regulators [Transcription]; Region: COG1733 931626001001 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 931626001002 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 931626001003 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931626001004 DNA binding residues [nucleotide binding] 931626001005 drug binding residues [chemical binding]; other site 931626001006 dimer interface [polypeptide binding]; other site 931626001007 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931626001008 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 931626001009 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 931626001010 homodimer interaction site [polypeptide binding]; other site 931626001011 cofactor binding site; other site 931626001012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626001013 S-adenosylmethionine binding site [chemical binding]; other site 931626001014 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931626001015 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626001016 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626001017 Radical SAM superfamily; Region: Radical_SAM; pfam04055 931626001018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626001019 FeS/SAM binding site; other site 931626001020 Transglutaminase/protease-like homologues; Region: TGc; smart00460 931626001021 hypothetical protein; Provisional; Region: PRK04435 931626001022 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 931626001023 homoserine kinase; Provisional; Region: PRK01212 931626001024 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 931626001025 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 931626001026 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 931626001027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626001028 catalytic residue [active] 931626001029 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 931626001030 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 931626001031 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 931626001032 aspartate kinase; Reviewed; Region: PRK06635 931626001033 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 931626001034 putative nucleotide binding site [chemical binding]; other site 931626001035 putative catalytic residues [active] 931626001036 putative Mg ion binding site [ion binding]; other site 931626001037 putative aspartate binding site [chemical binding]; other site 931626001038 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 931626001039 putative allosteric regulatory site; other site 931626001040 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 931626001041 putative allosteric regulatory residue; other site 931626001042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626001043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626001044 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626001045 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 931626001046 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 931626001047 substrate binding site [chemical binding]; other site 931626001048 ligand binding site [chemical binding]; other site 931626001049 3-isopropylmalate dehydratase, small subunit; Region: leuD; TIGR00171 931626001050 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 931626001051 substrate binding site [chemical binding]; other site 931626001052 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 931626001053 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 931626001054 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 931626001055 Walker A motif; other site 931626001056 ATP binding site [chemical binding]; other site 931626001057 Walker B motif; other site 931626001058 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 931626001059 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 931626001060 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 931626001061 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 931626001062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931626001063 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931626001064 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 931626001065 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 931626001066 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626001067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626001068 active site 931626001069 phosphorylation site [posttranslational modification] 931626001070 intermolecular recognition site; other site 931626001071 dimerization interface [polypeptide binding]; other site 931626001072 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626001073 DNA binding site [nucleotide binding] 931626001074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626001075 dimer interface [polypeptide binding]; other site 931626001076 phosphorylation site [posttranslational modification] 931626001077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626001078 ATP binding site [chemical binding]; other site 931626001079 Mg2+ binding site [ion binding]; other site 931626001080 G-X-G motif; other site 931626001081 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931626001082 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931626001083 active site 931626001084 NAD binding site [chemical binding]; other site 931626001085 metal binding site [ion binding]; metal-binding site 931626001086 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 931626001087 Part of AAA domain; Region: AAA_19; pfam13245 931626001088 Family description; Region: UvrD_C_2; pfam13538 931626001089 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 931626001090 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 931626001091 nucleotide binding pocket [chemical binding]; other site 931626001092 K-X-D-G motif; other site 931626001093 catalytic site [active] 931626001094 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 931626001095 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 931626001096 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 931626001097 Dimer interface [polypeptide binding]; other site 931626001098 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 931626001099 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 931626001100 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 931626001101 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 931626001102 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 931626001103 GatB domain; Region: GatB_Yqey; smart00845 931626001104 ribonuclease PH; Reviewed; Region: rph; PRK00173 931626001105 Ribonuclease PH; Region: RNase_PH_bact; cd11362 931626001106 hexamer interface [polypeptide binding]; other site 931626001107 active site 931626001108 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 931626001109 active site 931626001110 dimerization interface [polypeptide binding]; other site 931626001111 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 931626001112 active site 931626001113 metal binding site [ion binding]; metal-binding site 931626001114 homotetramer interface [polypeptide binding]; other site 931626001115 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626001116 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626001117 Walker A/P-loop; other site 931626001118 ATP binding site [chemical binding]; other site 931626001119 Q-loop/lid; other site 931626001120 ABC transporter signature motif; other site 931626001121 Walker B; other site 931626001122 D-loop; other site 931626001123 H-loop/switch region; other site 931626001124 ABC-2 type transporter; Region: ABC2_membrane; cl17235 931626001125 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 931626001126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626001127 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931626001128 putative substrate translocation pore; other site 931626001129 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 931626001130 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 931626001131 Domain of unknown function (DUF307); Region: DUF307; pfam03733 931626001132 hypothetical protein; Provisional; Region: PRK11770 931626001133 Domain of unknown function (DUF307); Region: DUF307; pfam03733 931626001134 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 931626001135 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 931626001136 Walker A/P-loop; other site 931626001137 ATP binding site [chemical binding]; other site 931626001138 Q-loop/lid; other site 931626001139 ABC transporter signature motif; other site 931626001140 Walker B; other site 931626001141 D-loop; other site 931626001142 H-loop/switch region; other site 931626001143 NIL domain; Region: NIL; pfam09383 931626001144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626001145 dimer interface [polypeptide binding]; other site 931626001146 conserved gate region; other site 931626001147 ABC-ATPase subunit interface; other site 931626001148 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 931626001149 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 931626001150 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931626001151 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931626001152 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626001153 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626001154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626001155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626001156 active site 931626001157 phosphorylation site [posttranslational modification] 931626001158 intermolecular recognition site; other site 931626001159 dimerization interface [polypeptide binding]; other site 931626001160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626001161 DNA binding site [nucleotide binding] 931626001162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626001163 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626001164 dimerization interface [polypeptide binding]; other site 931626001165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626001166 dimer interface [polypeptide binding]; other site 931626001167 phosphorylation site [posttranslational modification] 931626001168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626001169 ATP binding site [chemical binding]; other site 931626001170 Mg2+ binding site [ion binding]; other site 931626001171 G-X-G motif; other site 931626001172 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 931626001173 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 931626001174 putative dimer interface [polypeptide binding]; other site 931626001175 active site pocket [active] 931626001176 putative cataytic base [active] 931626001177 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 931626001178 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626001179 Walker A/P-loop; other site 931626001180 ATP binding site [chemical binding]; other site 931626001181 Q-loop/lid; other site 931626001182 ABC transporter signature motif; other site 931626001183 Walker B; other site 931626001184 D-loop; other site 931626001185 H-loop/switch region; other site 931626001186 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931626001187 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 931626001188 acyl-activating enzyme (AAE) consensus motif; other site 931626001189 AMP binding site [chemical binding]; other site 931626001190 active site 931626001191 CoA binding site [chemical binding]; other site 931626001192 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 931626001193 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 931626001194 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626001195 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626001196 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626001197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626001198 active site 931626001199 phosphorylation site [posttranslational modification] 931626001200 intermolecular recognition site; other site 931626001201 dimerization interface [polypeptide binding]; other site 931626001202 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626001203 DNA binding site [nucleotide binding] 931626001204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626001205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626001206 dimer interface [polypeptide binding]; other site 931626001207 phosphorylation site [posttranslational modification] 931626001208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626001209 ATP binding site [chemical binding]; other site 931626001210 Mg2+ binding site [ion binding]; other site 931626001211 G-X-G motif; other site 931626001212 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 931626001213 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 931626001214 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 931626001215 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 931626001216 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 931626001217 putative substrate binding site [chemical binding]; other site 931626001218 putative ATP binding site [chemical binding]; other site 931626001219 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 931626001220 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 931626001221 active site 931626001222 phosphorylation site [posttranslational modification] 931626001223 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 931626001224 active site 931626001225 P-loop; other site 931626001226 phosphorylation site [posttranslational modification] 931626001227 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 931626001228 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 931626001229 L-tyrosine decarboxylase; Provisional; Region: PRK13520 931626001230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626001231 catalytic residue [active] 931626001232 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 931626001233 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 931626001234 Cl binding site [ion binding]; other site 931626001235 oligomer interface [polypeptide binding]; other site 931626001236 Predicted membrane protein [Function unknown]; Region: COG3601 931626001237 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 931626001238 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 931626001239 active site 931626001240 catalytic residues [active] 931626001241 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626001242 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931626001243 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626001244 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626001245 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626001246 Clostridial hydrophobic W; Region: ChW; pfam07538 931626001247 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 931626001248 homodimer interface [polypeptide binding]; other site 931626001249 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 931626001250 active site pocket [active] 931626001251 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 931626001252 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 931626001253 trehalose synthase; Region: treS_nterm; TIGR02456 931626001254 active site 931626001255 homodimer interface [polypeptide binding]; other site 931626001256 catalytic site [active] 931626001257 glycogen synthase; Provisional; Region: glgA; PRK00654 931626001258 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 931626001259 ADP-binding pocket [chemical binding]; other site 931626001260 homodimer interface [polypeptide binding]; other site 931626001261 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 931626001262 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931626001263 active site 931626001264 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 931626001265 dimer interface [polypeptide binding]; other site 931626001266 N-terminal domain interface [polypeptide binding]; other site 931626001267 sulfate 1 binding site; other site 931626001268 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931626001269 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 931626001270 dimer interface [polypeptide binding]; other site 931626001271 N-terminal domain interface [polypeptide binding]; other site 931626001272 sulfate 1 binding site; other site 931626001273 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 931626001274 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 931626001275 homodimer interface [polypeptide binding]; other site 931626001276 active site pocket [active] 931626001277 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 931626001278 glycogen branching enzyme; Provisional; Region: PRK12313 931626001279 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 931626001280 active site 931626001281 catalytic site [active] 931626001282 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 931626001283 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 931626001284 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 931626001285 aconitate hydratase; Validated; Region: PRK07229 931626001286 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 931626001287 substrate binding site [chemical binding]; other site 931626001288 ligand binding site [chemical binding]; other site 931626001289 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 931626001290 substrate binding site [chemical binding]; other site 931626001291 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 931626001292 EDD domain protein, DegV family; Region: DegV; TIGR00762 931626001293 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 931626001294 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 931626001295 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 931626001296 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 931626001297 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 931626001298 RNA binding site [nucleotide binding]; other site 931626001299 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 931626001300 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 931626001301 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 931626001302 putative active site [active] 931626001303 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 931626001304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626001305 S-adenosylmethionine binding site [chemical binding]; other site 931626001306 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 931626001307 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 931626001308 putative trimer interface [polypeptide binding]; other site 931626001309 putative CoA binding site [chemical binding]; other site 931626001310 Uncharacterized conserved protein [Function unknown]; Region: COG1683 931626001311 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 931626001312 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 931626001313 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 931626001314 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 931626001315 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 931626001316 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 931626001317 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 931626001318 active site 931626001319 HIGH motif; other site 931626001320 KMSK motif region; other site 931626001321 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 931626001322 tRNA binding surface [nucleotide binding]; other site 931626001323 anticodon binding site; other site 931626001324 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 931626001325 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 931626001326 putative ATP binding site [chemical binding]; other site 931626001327 putative substrate interface [chemical binding]; other site 931626001328 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 931626001329 homotrimer interaction site [polypeptide binding]; other site 931626001330 zinc binding site [ion binding]; other site 931626001331 CDP-binding sites; other site 931626001332 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 931626001333 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 931626001334 alanine racemase; Reviewed; Region: alr; PRK00053 931626001335 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 931626001336 active site 931626001337 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 931626001338 dimer interface [polypeptide binding]; other site 931626001339 substrate binding site [chemical binding]; other site 931626001340 catalytic residues [active] 931626001341 transketolase; Reviewed; Region: PRK05899 931626001342 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 931626001343 TPP-binding site [chemical binding]; other site 931626001344 dimer interface [polypeptide binding]; other site 931626001345 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 931626001346 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931626001347 PYR/PP interface [polypeptide binding]; other site 931626001348 dimer interface [polypeptide binding]; other site 931626001349 TPP binding site [chemical binding]; other site 931626001350 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931626001351 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 931626001352 dimer interface [polypeptide binding]; other site 931626001353 FMN binding site [chemical binding]; other site 931626001354 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 931626001355 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 931626001356 G1 box; other site 931626001357 GTP/Mg2+ binding site [chemical binding]; other site 931626001358 G2 box; other site 931626001359 Switch I region; other site 931626001360 G3 box; other site 931626001361 Switch II region; other site 931626001362 G4 box; other site 931626001363 G5 box; other site 931626001364 MoxR-like ATPases [General function prediction only]; Region: COG0714 931626001365 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 931626001366 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 931626001367 metal ion-dependent adhesion site (MIDAS); other site 931626001368 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 931626001369 active site 931626001370 substrate binding site [chemical binding]; other site 931626001371 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 931626001372 FMN binding site [chemical binding]; other site 931626001373 putative catalytic residues [active] 931626001374 2-isopropylmalate synthase; Validated; Region: PRK00915 931626001375 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 931626001376 active site 931626001377 catalytic residues [active] 931626001378 metal binding site [ion binding]; metal-binding site 931626001379 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 931626001380 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 931626001381 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 931626001382 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 931626001383 NAD(P) binding site [chemical binding]; other site 931626001384 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626001385 Clostridial hydrophobic W; Region: ChW; pfam07538 931626001386 Clostridial hydrophobic W; Region: ChW; pfam07538 931626001387 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 931626001388 active site 931626001389 oxyanion hole [active] 931626001390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626001391 MarR family; Region: MarR_2; pfam12802 931626001392 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 931626001393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626001394 putative substrate translocation pore; other site 931626001395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626001396 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 931626001397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626001398 Coenzyme A binding pocket [chemical binding]; other site 931626001399 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 931626001400 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 931626001401 catalytic residues [active] 931626001402 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 931626001403 Predicted flavoprotein [General function prediction only]; Region: COG0431 931626001404 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626001405 Helix-turn-helix domain; Region: HTH_18; pfam12833 931626001406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626001407 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931626001408 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 931626001409 catalytic loop [active] 931626001410 iron binding site [ion binding]; other site 931626001411 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 931626001412 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 931626001413 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 931626001414 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626001415 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 931626001416 Cysteine-rich domain; Region: CCG; pfam02754 931626001417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626001418 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626001419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626001420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626001421 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931626001422 putative substrate translocation pore; other site 931626001423 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 931626001424 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 931626001425 active site 931626001426 catalytic site [active] 931626001427 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 931626001428 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 931626001429 active site 931626001430 catalytic site [active] 931626001431 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 931626001432 active site 931626001433 catalytic residues [active] 931626001434 metal binding site [ion binding]; metal-binding site 931626001435 Predicted transcriptional regulator [Transcription]; Region: COG2378 931626001436 HTH domain; Region: HTH_11; pfam08279 931626001437 WYL domain; Region: WYL; pfam13280 931626001438 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011 931626001439 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931626001440 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 931626001441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626001442 Coenzyme A binding pocket [chemical binding]; other site 931626001443 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 931626001444 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626001445 B12 binding site [chemical binding]; other site 931626001446 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 931626001447 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626001448 FeS/SAM binding site; other site 931626001449 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626001450 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 931626001451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626001452 FeS/SAM binding site; other site 931626001453 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 931626001454 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 931626001455 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626001456 FeS/SAM binding site; other site 931626001457 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 931626001458 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 931626001459 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626001460 B12 binding site [chemical binding]; other site 931626001461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626001462 FeS/SAM binding site; other site 931626001463 B12 binding domain; Region: B12-binding; pfam02310 931626001464 B12 binding site [chemical binding]; other site 931626001465 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 931626001466 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626001467 FeS/SAM binding site; other site 931626001468 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 931626001469 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 931626001470 ligand binding site [chemical binding]; other site 931626001471 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 931626001472 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 931626001473 lipoyl-biotinyl attachment site [posttranslational modification]; other site 931626001474 HlyD family secretion protein; Region: HlyD_3; pfam13437 931626001475 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 931626001476 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 931626001477 putative active site [active] 931626001478 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626001479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626001480 Walker A/P-loop; other site 931626001481 ATP binding site [chemical binding]; other site 931626001482 Q-loop/lid; other site 931626001483 ABC transporter signature motif; other site 931626001484 Walker B; other site 931626001485 D-loop; other site 931626001486 H-loop/switch region; other site 931626001487 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 931626001488 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626001489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626001490 Walker A/P-loop; other site 931626001491 ATP binding site [chemical binding]; other site 931626001492 Q-loop/lid; other site 931626001493 ABC transporter signature motif; other site 931626001494 Walker B; other site 931626001495 D-loop; other site 931626001496 H-loop/switch region; other site 931626001497 Rubrerythrin [Energy production and conversion]; Region: COG1592 931626001498 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 931626001499 binuclear metal center [ion binding]; other site 931626001500 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 931626001501 iron binding site [ion binding]; other site 931626001502 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 931626001503 synthetase active site [active] 931626001504 NTP binding site [chemical binding]; other site 931626001505 metal binding site [ion binding]; metal-binding site 931626001506 PAS domain S-box; Region: sensory_box; TIGR00229 931626001507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626001508 putative active site [active] 931626001509 heme pocket [chemical binding]; other site 931626001510 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626001511 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626001512 metal binding site [ion binding]; metal-binding site 931626001513 active site 931626001514 I-site; other site 931626001515 calcium/proton exchanger (cax); Region: cax; TIGR00378 931626001516 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 931626001517 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 931626001518 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 931626001519 Beta-lactamase; Region: Beta-lactamase; pfam00144 931626001520 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931626001521 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931626001522 active site 931626001523 FMN binding site [chemical binding]; other site 931626001524 substrate binding site [chemical binding]; other site 931626001525 putative catalytic residue [active] 931626001526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626001527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626001528 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931626001529 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931626001530 active site 931626001531 NAD binding site [chemical binding]; other site 931626001532 metal binding site [ion binding]; metal-binding site 931626001533 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 931626001534 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931626001535 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931626001536 EamA-like transporter family; Region: EamA; pfam00892 931626001537 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626001538 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626001539 Clostridial hydrophobic W; Region: ChW; pfam07538 931626001540 Clostridial hydrophobic W; Region: ChW; pfam07538 931626001541 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626001542 Clostridial hydrophobic W; Region: ChW; pfam07538 931626001543 Clostridial hydrophobic W; Region: ChW; pfam07538 931626001544 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 931626001545 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 931626001546 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 931626001547 Ligand Binding Site [chemical binding]; other site 931626001548 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 931626001549 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 931626001550 putative active site [active] 931626001551 PhoH-like protein; Region: PhoH; pfam02562 931626001552 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 931626001553 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 931626001554 G1 box; other site 931626001555 GTP/Mg2+ binding site [chemical binding]; other site 931626001556 Switch I region; other site 931626001557 G2 box; other site 931626001558 Switch II region; other site 931626001559 G3 box; other site 931626001560 G4 box; other site 931626001561 G5 box; other site 931626001562 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 931626001563 Aspartase; Region: Aspartase; cd01357 931626001564 active sites [active] 931626001565 tetramer interface [polypeptide binding]; other site 931626001566 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 931626001567 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 931626001568 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 931626001569 trimer interface [polypeptide binding]; other site 931626001570 active site 931626001571 substrate binding site [chemical binding]; other site 931626001572 CoA binding site [chemical binding]; other site 931626001573 Predicted transcriptional regulator [Transcription]; Region: COG2378 931626001574 HTH domain; Region: HTH_11; pfam08279 931626001575 WYL domain; Region: WYL; pfam13280 931626001576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 931626001577 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 931626001578 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 931626001579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626001580 active site 931626001581 phosphorylation site [posttranslational modification] 931626001582 intermolecular recognition site; other site 931626001583 dimerization interface [polypeptide binding]; other site 931626001584 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626001585 Zn2+ binding site [ion binding]; other site 931626001586 Mg2+ binding site [ion binding]; other site 931626001587 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626001588 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626001589 substrate binding pocket [chemical binding]; other site 931626001590 membrane-bound complex binding site; other site 931626001591 hinge residues; other site 931626001592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626001593 dimer interface [polypeptide binding]; other site 931626001594 phosphorylation site [posttranslational modification] 931626001595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626001596 ATP binding site [chemical binding]; other site 931626001597 Mg2+ binding site [ion binding]; other site 931626001598 G-X-G motif; other site 931626001599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626001600 active site 931626001601 phosphorylation site [posttranslational modification] 931626001602 intermolecular recognition site; other site 931626001603 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931626001604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626001605 active site 931626001606 phosphorylation site [posttranslational modification] 931626001607 intermolecular recognition site; other site 931626001608 dimerization interface [polypeptide binding]; other site 931626001609 benzoate transport; Region: 2A0115; TIGR00895 931626001610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626001611 putative substrate translocation pore; other site 931626001612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626001613 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 931626001614 FMN-binding domain; Region: FMN_bind; cl01081 931626001615 MarR family; Region: MarR_2; cl17246 931626001616 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626001617 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 931626001618 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 931626001619 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 931626001620 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626001621 FeS/SAM binding site; other site 931626001622 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 931626001623 ATP cone domain; Region: ATP-cone; pfam03477 931626001624 Class III ribonucleotide reductase; Region: RNR_III; cd01675 931626001625 effector binding site; other site 931626001626 active site 931626001627 Zn binding site [ion binding]; other site 931626001628 glycine loop; other site 931626001629 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 931626001630 catalytic residues [active] 931626001631 potential frameshift: common BLAST hit: gi|258517164|ref|YP_003193386.1| transposase IS204/IS1001/IS1096/IS1165 family protein 931626001632 Transposase; Region: DDE_Tnp_ISL3; pfam01610 931626001633 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 931626001634 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 931626001635 HsdM N-terminal domain; Region: HsdM_N; pfam12161 931626001636 Methyltransferase domain; Region: Methyltransf_26; pfam13659 931626001637 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 931626001638 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 931626001639 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 931626001640 SIR2-like domain; Region: SIR2_2; pfam13289 931626001641 FRG domain; Region: FRG; pfam08867 931626001642 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 931626001643 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 931626001644 catalytic residues [active] 931626001645 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 931626001646 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 931626001647 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 931626001648 DNA binding site [nucleotide binding] 931626001649 active site 931626001650 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 931626001651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626001652 putative substrate translocation pore; other site 931626001653 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 931626001654 Uncharacterized conserved protein [Function unknown]; Region: COG3379 931626001655 Predicted permeases [General function prediction only]; Region: COG0701 931626001656 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 931626001657 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 931626001658 Low molecular weight phosphatase family; Region: LMWPc; cl00105 931626001659 active site 931626001660 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 931626001661 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 931626001662 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931626001663 Soluble P-type ATPase [General function prediction only]; Region: COG4087 931626001664 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 931626001665 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 931626001666 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931626001667 ABC-ATPase subunit interface; other site 931626001668 dimer interface [polypeptide binding]; other site 931626001669 putative PBP binding regions; other site 931626001670 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 931626001671 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 931626001672 Walker A/P-loop; other site 931626001673 ATP binding site [chemical binding]; other site 931626001674 Q-loop/lid; other site 931626001675 ABC transporter signature motif; other site 931626001676 Walker B; other site 931626001677 D-loop; other site 931626001678 H-loop/switch region; other site 931626001679 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 931626001680 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 931626001681 intersubunit interface [polypeptide binding]; other site 931626001682 Leucine rich repeat; Region: LRR_8; pfam13855 931626001683 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 931626001684 Substrate binding site [chemical binding]; other site 931626001685 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 931626001686 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 931626001687 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 931626001688 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 931626001689 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 931626001690 Divergent AAA domain; Region: AAA_4; pfam04326 931626001691 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 931626001692 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931626001693 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 931626001694 active site 931626001695 metal binding site [ion binding]; metal-binding site 931626001696 DJ-1 family protein; Region: not_thiJ; TIGR01383 931626001697 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 931626001698 conserved cys residue [active] 931626001699 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626001700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626001701 non-specific DNA binding site [nucleotide binding]; other site 931626001702 salt bridge; other site 931626001703 sequence-specific DNA binding site [nucleotide binding]; other site 931626001704 TfoX C-terminal domain; Region: TfoX_C; pfam04994 931626001705 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 931626001706 GAF domain; Region: GAF; pfam01590 931626001707 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 931626001708 Beta-lactamase; Region: Beta-lactamase; pfam00144 931626001709 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 931626001710 active site 931626001711 catalytic triad [active] 931626001712 oxyanion hole [active] 931626001713 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 931626001714 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 931626001715 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626001716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626001717 Walker A/P-loop; other site 931626001718 ATP binding site [chemical binding]; other site 931626001719 Q-loop/lid; other site 931626001720 ABC transporter signature motif; other site 931626001721 Walker B; other site 931626001722 D-loop; other site 931626001723 H-loop/switch region; other site 931626001724 Domain of unknown function (DUF364); Region: DUF364; pfam04016 931626001725 AAA domain; Region: AAA_33; pfam13671 931626001726 AAA domain; Region: AAA_17; pfam13207 931626001727 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 931626001728 Na2 binding site [ion binding]; other site 931626001729 putative substrate binding site 1 [chemical binding]; other site 931626001730 Na binding site 1 [ion binding]; other site 931626001731 putative substrate binding site 2 [chemical binding]; other site 931626001732 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626001733 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626001734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626001735 Walker A/P-loop; other site 931626001736 ATP binding site [chemical binding]; other site 931626001737 Q-loop/lid; other site 931626001738 ABC transporter signature motif; other site 931626001739 Walker B; other site 931626001740 D-loop; other site 931626001741 H-loop/switch region; other site 931626001742 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626001743 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626001744 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 931626001745 Walker A/P-loop; other site 931626001746 ATP binding site [chemical binding]; other site 931626001747 Q-loop/lid; other site 931626001748 ABC transporter signature motif; other site 931626001749 Walker B; other site 931626001750 D-loop; other site 931626001751 H-loop/switch region; other site 931626001752 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 931626001753 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 931626001754 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 931626001755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626001756 dimer interface [polypeptide binding]; other site 931626001757 conserved gate region; other site 931626001758 putative PBP binding loops; other site 931626001759 ABC-ATPase subunit interface; other site 931626001760 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 931626001761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626001762 putative PBP binding loops; other site 931626001763 ABC-ATPase subunit interface; other site 931626001764 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 931626001765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931626001766 Walker A/P-loop; other site 931626001767 ATP binding site [chemical binding]; other site 931626001768 Q-loop/lid; other site 931626001769 ABC transporter signature motif; other site 931626001770 Walker B; other site 931626001771 D-loop; other site 931626001772 H-loop/switch region; other site 931626001773 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 931626001774 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 931626001775 Walker A/P-loop; other site 931626001776 ATP binding site [chemical binding]; other site 931626001777 Q-loop/lid; other site 931626001778 ABC transporter signature motif; other site 931626001779 Walker B; other site 931626001780 D-loop; other site 931626001781 H-loop/switch region; other site 931626001782 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 931626001783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626001784 S-adenosylmethionine binding site [chemical binding]; other site 931626001785 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626001786 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626001787 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 931626001788 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 931626001789 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 931626001790 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931626001791 ABC-ATPase subunit interface; other site 931626001792 dimer interface [polypeptide binding]; other site 931626001793 putative PBP binding regions; other site 931626001794 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 931626001795 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 931626001796 Walker A/P-loop; other site 931626001797 ATP binding site [chemical binding]; other site 931626001798 Q-loop/lid; other site 931626001799 ABC transporter signature motif; other site 931626001800 Walker B; other site 931626001801 D-loop; other site 931626001802 H-loop/switch region; other site 931626001803 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 931626001804 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 931626001805 putative metal binding site [ion binding]; other site 931626001806 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 931626001807 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 931626001808 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 931626001809 catalytic residues [active] 931626001810 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 931626001811 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931626001812 ligand binding site [chemical binding]; other site 931626001813 flexible hinge region; other site 931626001814 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 931626001815 non-specific DNA interactions [nucleotide binding]; other site 931626001816 DNA binding site [nucleotide binding] 931626001817 sequence specific DNA binding site [nucleotide binding]; other site 931626001818 putative cAMP binding site [chemical binding]; other site 931626001819 hypothetical protein; Provisional; Region: PRK01346 931626001820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626001821 Coenzyme A binding pocket [chemical binding]; other site 931626001822 Sterol carrier protein domain; Region: SCP2_2; pfam13530 931626001823 SPRY domain; Region: SPRY; cl02614 931626001824 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 931626001825 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 931626001826 catalytic residues [active] 931626001827 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 931626001828 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 931626001829 4Fe-4S binding domain; Region: Fer4; pfam00037 931626001830 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 931626001831 substrate binding site [chemical binding]; other site 931626001832 multimerization interface [polypeptide binding]; other site 931626001833 ATP binding site [chemical binding]; other site 931626001834 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 931626001835 thiamine phosphate binding site [chemical binding]; other site 931626001836 active site 931626001837 pyrophosphate binding site [ion binding]; other site 931626001838 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 931626001839 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 931626001840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626001841 motif II; other site 931626001842 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 931626001843 dimer interface [polypeptide binding]; other site 931626001844 substrate binding site [chemical binding]; other site 931626001845 ATP binding site [chemical binding]; other site 931626001846 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931626001847 EamA-like transporter family; Region: EamA; cl17759 931626001848 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626001849 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626001850 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 931626001851 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 931626001852 substrate binding pocket [chemical binding]; other site 931626001853 dimer interface [polypeptide binding]; other site 931626001854 inhibitor binding site; inhibition site 931626001855 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626001856 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626001857 B12 binding site [chemical binding]; other site 931626001858 cobalt ligand [ion binding]; other site 931626001859 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 931626001860 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626001861 MarR family; Region: MarR_2; pfam12802 931626001862 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 931626001863 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 931626001864 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931626001865 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 931626001866 predicted active site [active] 931626001867 catalytic triad [active] 931626001868 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 931626001869 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 931626001870 active site 931626001871 multimer interface [polypeptide binding]; other site 931626001872 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 931626001873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626001874 active site 931626001875 phosphorylation site [posttranslational modification] 931626001876 intermolecular recognition site; other site 931626001877 dimerization interface [polypeptide binding]; other site 931626001878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626001879 Zn2+ binding site [ion binding]; other site 931626001880 Mg2+ binding site [ion binding]; other site 931626001881 PAS fold; Region: PAS; pfam00989 931626001882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626001883 putative active site [active] 931626001884 heme pocket [chemical binding]; other site 931626001885 PAS domain S-box; Region: sensory_box; TIGR00229 931626001886 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 931626001887 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 931626001888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626001889 dimer interface [polypeptide binding]; other site 931626001890 phosphorylation site [posttranslational modification] 931626001891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626001892 ATP binding site [chemical binding]; other site 931626001893 Mg2+ binding site [ion binding]; other site 931626001894 G-X-G motif; other site 931626001895 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931626001896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626001897 active site 931626001898 phosphorylation site [posttranslational modification] 931626001899 intermolecular recognition site; other site 931626001900 dimerization interface [polypeptide binding]; other site 931626001901 Response regulator receiver domain; Region: Response_reg; pfam00072 931626001902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626001903 active site 931626001904 phosphorylation site [posttranslational modification] 931626001905 intermolecular recognition site; other site 931626001906 dimerization interface [polypeptide binding]; other site 931626001907 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 931626001908 putative binding surface; other site 931626001909 active site 931626001910 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 931626001911 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931626001912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931626001913 DNA binding residues [nucleotide binding] 931626001914 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 931626001915 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 931626001916 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931626001917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626001918 catalytic residue [active] 931626001919 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 931626001920 spermidine synthase; Provisional; Region: PRK00811 931626001921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626001922 S-adenosylmethionine binding site [chemical binding]; other site 931626001923 agmatinase; Region: agmatinase; TIGR01230 931626001924 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 931626001925 putative active site [active] 931626001926 Mn binding site [ion binding]; other site 931626001927 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 931626001928 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 931626001929 NAD(P) binding pocket [chemical binding]; other site 931626001930 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 931626001931 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 931626001932 dimer interface [polypeptide binding]; other site 931626001933 active site 931626001934 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 931626001935 catalytic residues [active] 931626001936 substrate binding site [chemical binding]; other site 931626001937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626001938 S-adenosylmethionine binding site [chemical binding]; other site 931626001939 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 931626001940 CoenzymeA binding site [chemical binding]; other site 931626001941 subunit interaction site [polypeptide binding]; other site 931626001942 PHB binding site; other site 931626001943 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 931626001944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626001945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626001946 non-specific DNA binding site [nucleotide binding]; other site 931626001947 salt bridge; other site 931626001948 sequence-specific DNA binding site [nucleotide binding]; other site 931626001949 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626001950 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626001951 B12 binding site [chemical binding]; other site 931626001952 cobalt ligand [ion binding]; other site 931626001953 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 931626001954 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 931626001955 BCCT family transporter; Region: BCCT; pfam02028 931626001956 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626001957 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626001958 B12 binding site [chemical binding]; other site 931626001959 cobalt ligand [ion binding]; other site 931626001960 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 931626001961 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 931626001962 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 931626001963 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 931626001964 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 931626001965 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 931626001966 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 931626001967 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931626001968 catalytic loop [active] 931626001969 iron binding site [ion binding]; other site 931626001970 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 931626001971 putative deacylase active site [active] 931626001972 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 931626001973 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 931626001974 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 931626001975 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 931626001976 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 931626001977 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 931626001978 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 931626001979 TrkA-N domain; Region: TrkA_N; pfam02254 931626001980 TrkA-C domain; Region: TrkA_C; pfam02080 931626001981 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 931626001982 TrkA-N domain; Region: TrkA_N; pfam02254 931626001983 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626001984 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626001985 TPR repeat; Region: TPR_11; pfam13414 931626001986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 931626001987 TPR motif; other site 931626001988 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 931626001989 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931626001990 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 931626001991 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 931626001992 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 931626001993 Ligand Binding Site [chemical binding]; other site 931626001994 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 931626001995 GAF domain; Region: GAF_3; pfam13492 931626001996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626001997 dimer interface [polypeptide binding]; other site 931626001998 phosphorylation site [posttranslational modification] 931626001999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626002000 ATP binding site [chemical binding]; other site 931626002001 Mg2+ binding site [ion binding]; other site 931626002002 G-X-G motif; other site 931626002003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626002004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626002005 active site 931626002006 phosphorylation site [posttranslational modification] 931626002007 intermolecular recognition site; other site 931626002008 dimerization interface [polypeptide binding]; other site 931626002009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626002010 DNA binding site [nucleotide binding] 931626002011 PAS fold; Region: PAS_4; pfam08448 931626002012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626002013 putative active site [active] 931626002014 heme pocket [chemical binding]; other site 931626002015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626002016 PAS domain; Region: PAS_9; pfam13426 931626002017 putative active site [active] 931626002018 heme pocket [chemical binding]; other site 931626002019 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626002020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626002021 metal binding site [ion binding]; metal-binding site 931626002022 active site 931626002023 I-site; other site 931626002024 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626002025 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626002026 Zn2+ binding site [ion binding]; other site 931626002027 Mg2+ binding site [ion binding]; other site 931626002028 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626002029 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626002030 metal binding site [ion binding]; metal-binding site 931626002031 active site 931626002032 I-site; other site 931626002033 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626002034 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626002035 Zn2+ binding site [ion binding]; other site 931626002036 Mg2+ binding site [ion binding]; other site 931626002037 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931626002038 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931626002039 active site 931626002040 NAD binding site [chemical binding]; other site 931626002041 metal binding site [ion binding]; metal-binding site 931626002042 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626002043 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 931626002044 FOG: CBS domain [General function prediction only]; Region: COG0517 931626002045 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626002046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626002047 metal binding site [ion binding]; metal-binding site 931626002048 active site 931626002049 I-site; other site 931626002050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 931626002051 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 931626002052 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 931626002053 Accessory gene regulator B; Region: AgrB; pfam04647 931626002054 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 931626002055 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626002056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626002057 metal binding site [ion binding]; metal-binding site 931626002058 active site 931626002059 I-site; other site 931626002060 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626002061 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626002062 Zn2+ binding site [ion binding]; other site 931626002063 Mg2+ binding site [ion binding]; other site 931626002064 Cupin domain; Region: Cupin_2; cl17218 931626002065 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626002066 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626002067 substrate binding pocket [chemical binding]; other site 931626002068 membrane-bound complex binding site; other site 931626002069 hinge residues; other site 931626002070 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 931626002071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626002072 dimer interface [polypeptide binding]; other site 931626002073 conserved gate region; other site 931626002074 putative PBP binding loops; other site 931626002075 ABC-ATPase subunit interface; other site 931626002076 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931626002077 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626002078 Walker A/P-loop; other site 931626002079 ATP binding site [chemical binding]; other site 931626002080 Q-loop/lid; other site 931626002081 ABC transporter signature motif; other site 931626002082 Walker B; other site 931626002083 D-loop; other site 931626002084 H-loop/switch region; other site 931626002085 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 931626002086 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 931626002087 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 931626002088 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 931626002089 PAS domain S-box; Region: sensory_box; TIGR00229 931626002090 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626002091 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626002092 metal binding site [ion binding]; metal-binding site 931626002093 active site 931626002094 I-site; other site 931626002095 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626002096 Zn2+ binding site [ion binding]; other site 931626002097 Mg2+ binding site [ion binding]; other site 931626002098 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 931626002099 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 931626002100 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931626002101 PAS domain S-box; Region: sensory_box; TIGR00229 931626002102 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626002103 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626002104 metal binding site [ion binding]; metal-binding site 931626002105 active site 931626002106 I-site; other site 931626002107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626002108 active site 931626002109 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 931626002110 phosphorylation site [posttranslational modification] 931626002111 intermolecular recognition site; other site 931626002112 dimerization interface [polypeptide binding]; other site 931626002113 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626002114 putative active site [active] 931626002115 heme pocket [chemical binding]; other site 931626002116 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626002117 metal binding site [ion binding]; metal-binding site 931626002118 active site 931626002119 I-site; other site 931626002120 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626002121 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626002122 Zn2+ binding site [ion binding]; other site 931626002123 Mg2+ binding site [ion binding]; other site 931626002124 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 931626002125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626002126 S-adenosylmethionine binding site [chemical binding]; other site 931626002127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626002128 dimerization interface [polypeptide binding]; other site 931626002129 GAF domain; Region: GAF; pfam01590 931626002130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626002131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626002132 dimer interface [polypeptide binding]; other site 931626002133 phosphorylation site [posttranslational modification] 931626002134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626002135 ATP binding site [chemical binding]; other site 931626002136 Mg2+ binding site [ion binding]; other site 931626002137 G-X-G motif; other site 931626002138 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931626002139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626002140 active site 931626002141 phosphorylation site [posttranslational modification] 931626002142 intermolecular recognition site; other site 931626002143 dimerization interface [polypeptide binding]; other site 931626002144 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931626002145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626002146 active site 931626002147 phosphorylation site [posttranslational modification] 931626002148 intermolecular recognition site; other site 931626002149 dimerization interface [polypeptide binding]; other site 931626002150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626002151 Response regulator receiver domain; Region: Response_reg; pfam00072 931626002152 active site 931626002153 phosphorylation site [posttranslational modification] 931626002154 intermolecular recognition site; other site 931626002155 dimerization interface [polypeptide binding]; other site 931626002156 PAS domain S-box; Region: sensory_box; TIGR00229 931626002157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626002158 putative active site [active] 931626002159 heme pocket [chemical binding]; other site 931626002160 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626002161 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626002162 metal binding site [ion binding]; metal-binding site 931626002163 active site 931626002164 I-site; other site 931626002165 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626002166 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626002167 Zn2+ binding site [ion binding]; other site 931626002168 Mg2+ binding site [ion binding]; other site 931626002169 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 931626002170 active site clefts [active] 931626002171 zinc binding site [ion binding]; other site 931626002172 dimer interface [polypeptide binding]; other site 931626002173 serpin-like protein; Provisional; Region: PHA02660 931626002174 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 931626002175 reactive center loop; other site 931626002176 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 931626002177 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626002178 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 931626002179 Nitroreductase family; Region: Nitroreductase; pfam00881 931626002180 FMN binding site [chemical binding]; other site 931626002181 dimer interface [polypeptide binding]; other site 931626002182 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 931626002183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626002184 Walker A/P-loop; other site 931626002185 ATP binding site [chemical binding]; other site 931626002186 Q-loop/lid; other site 931626002187 ABC transporter signature motif; other site 931626002188 Walker B; other site 931626002189 D-loop; other site 931626002190 H-loop/switch region; other site 931626002191 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 931626002192 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 931626002193 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931626002194 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931626002195 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 931626002196 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626002197 Walker A/P-loop; other site 931626002198 ATP binding site [chemical binding]; other site 931626002199 Q-loop/lid; other site 931626002200 ABC transporter signature motif; other site 931626002201 Walker B; other site 931626002202 D-loop; other site 931626002203 H-loop/switch region; other site 931626002204 Predicted transcriptional regulators [Transcription]; Region: COG1695 931626002205 Transcriptional regulator PadR-like family; Region: PadR; cl17335 931626002206 Homoserine O-succinyltransferase; Region: HTS; pfam04204 931626002207 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 931626002208 proposed active site lysine [active] 931626002209 conserved cys residue [active] 931626002210 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 931626002211 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 931626002212 homodimer interface [polypeptide binding]; other site 931626002213 substrate-cofactor binding pocket; other site 931626002214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626002215 catalytic residue [active] 931626002216 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 931626002217 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 931626002218 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 931626002219 prephenate dehydrogenase; Validated; Region: PRK08507 931626002220 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 931626002221 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 931626002222 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 931626002223 glutamine binding [chemical binding]; other site 931626002224 catalytic triad [active] 931626002225 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 931626002226 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 931626002227 chorismate binding enzyme; Region: Chorismate_bind; cl10555 931626002228 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 931626002229 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 931626002230 homodimer interface [polypeptide binding]; other site 931626002231 substrate-cofactor binding pocket; other site 931626002232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626002233 catalytic residue [active] 931626002234 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 931626002235 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 931626002236 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 931626002237 active site 931626002238 NTP binding site [chemical binding]; other site 931626002239 metal binding triad [ion binding]; metal-binding site 931626002240 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 931626002241 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626002242 Zn2+ binding site [ion binding]; other site 931626002243 Mg2+ binding site [ion binding]; other site 931626002244 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 931626002245 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 931626002246 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 931626002247 active site 931626002248 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 931626002249 putative FMN binding site [chemical binding]; other site 931626002250 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 931626002251 Chromate transporter; Region: Chromate_transp; pfam02417 931626002252 Chromate transporter; Region: Chromate_transp; pfam02417 931626002253 FMN-binding domain; Region: FMN_bind; cl01081 931626002254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931626002255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931626002256 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 931626002257 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931626002258 putative active site [active] 931626002259 metal binding site [ion binding]; metal-binding site 931626002260 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 931626002261 Sel1-like repeats; Region: SEL1; smart00671 931626002262 Sel1-like repeats; Region: SEL1; smart00671 931626002263 Sel1 repeat; Region: Sel1; cl02723 931626002264 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 931626002265 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 931626002266 TPP-binding site [chemical binding]; other site 931626002267 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 931626002268 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 931626002269 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 931626002270 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 931626002271 dimer interface [polypeptide binding]; other site 931626002272 PYR/PP interface [polypeptide binding]; other site 931626002273 TPP binding site [chemical binding]; other site 931626002274 substrate binding site [chemical binding]; other site 931626002275 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931626002276 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931626002277 active site 931626002278 NAD binding site [chemical binding]; other site 931626002279 metal binding site [ion binding]; metal-binding site 931626002280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626002281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626002282 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931626002283 dimerization interface [polypeptide binding]; other site 931626002284 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 931626002285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626002286 S-adenosylmethionine binding site [chemical binding]; other site 931626002287 Part of AAA domain; Region: AAA_19; pfam13245 931626002288 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 931626002289 Family description; Region: UvrD_C_2; pfam13538 931626002290 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626002291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626002292 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 931626002293 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 931626002294 putative catalytic cysteine [active] 931626002295 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 931626002296 putative active site [active] 931626002297 metal binding site [ion binding]; metal-binding site 931626002298 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 931626002299 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931626002300 acyl-activating enzyme (AAE) consensus motif; other site 931626002301 AMP binding site [chemical binding]; other site 931626002302 active site 931626002303 CoA binding site [chemical binding]; other site 931626002304 enolase; Provisional; Region: eno; PRK00077 931626002305 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 931626002306 dimer interface [polypeptide binding]; other site 931626002307 metal binding site [ion binding]; metal-binding site 931626002308 substrate binding pocket [chemical binding]; other site 931626002309 hypothetical protein; Provisional; Region: PRK03881 931626002310 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 931626002311 AMMECR1; Region: AMMECR1; pfam01871 931626002312 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 931626002313 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 931626002314 minor groove reading motif; other site 931626002315 helix-hairpin-helix signature motif; other site 931626002316 substrate binding pocket [chemical binding]; other site 931626002317 active site 931626002318 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 931626002319 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 931626002320 DNA binding and oxoG recognition site [nucleotide binding] 931626002321 Domain of unknown function (DUF348); Region: DUF348; pfam03990 931626002322 G5 domain; Region: G5; pfam07501 931626002323 3D domain; Region: 3D; cl01439 931626002324 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 931626002325 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 931626002326 homodimer interface [polypeptide binding]; other site 931626002327 substrate-cofactor binding pocket; other site 931626002328 catalytic residue [active] 931626002329 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 931626002330 Recombinase; Region: Recombinase; pfam07508 931626002331 TIR domain; Region: TIR_2; pfam13676 931626002332 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 931626002333 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626002334 FeS/SAM binding site; other site 931626002335 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 931626002336 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 931626002337 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931626002338 active site 931626002339 DNA binding site [nucleotide binding] 931626002340 Int/Topo IB signature motif; other site 931626002341 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 931626002342 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 931626002343 cofactor binding site; other site 931626002344 DNA binding site [nucleotide binding] 931626002345 substrate interaction site [chemical binding]; other site 931626002346 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 931626002347 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931626002348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 931626002349 active site 931626002350 phosphorylation site [posttranslational modification] 931626002351 intermolecular recognition site; other site 931626002352 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 931626002353 additional DNA contacts [nucleotide binding]; other site 931626002354 mismatch recognition site; other site 931626002355 active site 931626002356 zinc binding site [ion binding]; other site 931626002357 DNA intercalation site [nucleotide binding]; other site 931626002358 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 931626002359 Uncharacterized conserved protein [Function unknown]; Region: COG3586 931626002360 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 931626002361 homotrimer interaction site [polypeptide binding]; other site 931626002362 putative active site [active] 931626002363 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 931626002364 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 931626002365 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931626002366 DNA binding residues [nucleotide binding] 931626002367 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 931626002368 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 931626002369 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 931626002370 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 931626002371 active site 931626002372 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 931626002373 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 931626002374 Uncharacterized conserved protein [Function unknown]; Region: COG5361 931626002375 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 931626002376 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 931626002377 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 931626002378 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 931626002379 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 931626002380 Domain of unknown function (DUF364); Region: DUF364; pfam04016 931626002381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626002382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626002383 active site 931626002384 phosphorylation site [posttranslational modification] 931626002385 intermolecular recognition site; other site 931626002386 dimerization interface [polypeptide binding]; other site 931626002387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626002388 DNA binding site [nucleotide binding] 931626002389 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626002390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626002391 dimer interface [polypeptide binding]; other site 931626002392 phosphorylation site [posttranslational modification] 931626002393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626002394 ATP binding site [chemical binding]; other site 931626002395 Mg2+ binding site [ion binding]; other site 931626002396 G-X-G motif; other site 931626002397 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 931626002398 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 931626002399 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 931626002400 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 931626002401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626002402 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 931626002403 FeS/SAM binding site; other site 931626002404 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 931626002405 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 931626002406 molybdopterin cofactor binding site; other site 931626002407 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 931626002408 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 931626002409 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 931626002410 catalytic triad [active] 931626002411 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 931626002412 putative active site pocket [active] 931626002413 dimerization interface [polypeptide binding]; other site 931626002414 putative catalytic residue [active] 931626002415 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 931626002416 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 931626002417 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626002418 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626002419 metal binding site [ion binding]; metal-binding site 931626002420 active site 931626002421 I-site; other site 931626002422 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 931626002423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 931626002424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626002425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626002426 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626002427 EamA-like transporter family; Region: EamA; pfam00892 931626002428 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 931626002429 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 931626002430 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 931626002431 putative active site [active] 931626002432 metal binding site [ion binding]; metal-binding site 931626002433 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 931626002434 zinc binding site [ion binding]; other site 931626002435 putative ligand binding site [chemical binding]; other site 931626002436 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931626002437 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 931626002438 TM-ABC transporter signature motif; other site 931626002439 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 931626002440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626002441 Walker A/P-loop; other site 931626002442 ATP binding site [chemical binding]; other site 931626002443 Q-loop/lid; other site 931626002444 ABC transporter signature motif; other site 931626002445 Walker B; other site 931626002446 D-loop; other site 931626002447 H-loop/switch region; other site 931626002448 Cupin domain; Region: Cupin_2; pfam07883 931626002449 TOBE domain; Region: TOBE; cl01440 931626002450 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 931626002451 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931626002452 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931626002453 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 931626002454 nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861 931626002455 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 931626002456 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 931626002457 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931626002458 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 931626002459 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931626002460 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 931626002461 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142 931626002462 Nucleotide-binding sites [chemical binding]; other site 931626002463 Walker A motif; other site 931626002464 Switch I region of nucleotide binding site; other site 931626002465 Fe4S4 binding sites [ion binding]; other site 931626002466 Switch II region of nucleotide binding site; other site 931626002467 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626002468 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626002469 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626002470 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626002471 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 931626002472 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 931626002473 dimer interface [polypeptide binding]; other site 931626002474 active site 931626002475 Helix-turn-helix domain; Region: HTH_17; pfam12728 931626002476 PBP superfamily domain; Region: PBP_like; pfam12727 931626002477 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931626002478 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931626002479 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626002480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626002481 Walker A/P-loop; other site 931626002482 ATP binding site [chemical binding]; other site 931626002483 Q-loop/lid; other site 931626002484 ABC transporter signature motif; other site 931626002485 Walker B; other site 931626002486 D-loop; other site 931626002487 H-loop/switch region; other site 931626002488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 931626002489 Histidine kinase; Region: HisKA_3; pfam07730 931626002490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626002491 ATP binding site [chemical binding]; other site 931626002492 Mg2+ binding site [ion binding]; other site 931626002493 G-X-G motif; other site 931626002494 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931626002495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626002496 active site 931626002497 phosphorylation site [posttranslational modification] 931626002498 intermolecular recognition site; other site 931626002499 dimerization interface [polypeptide binding]; other site 931626002500 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931626002501 DNA binding residues [nucleotide binding] 931626002502 dimerization interface [polypeptide binding]; other site 931626002503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626002504 PAS fold; Region: PAS_3; pfam08447 931626002505 putative active site [active] 931626002506 heme pocket [chemical binding]; other site 931626002507 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626002508 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626002509 metal binding site [ion binding]; metal-binding site 931626002510 active site 931626002511 I-site; other site 931626002512 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626002513 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626002514 Zn2+ binding site [ion binding]; other site 931626002515 Mg2+ binding site [ion binding]; other site 931626002516 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626002517 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626002518 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 931626002519 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 931626002520 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 931626002521 putative active site [active] 931626002522 catalytic site [active] 931626002523 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 931626002524 putative active site [active] 931626002525 catalytic site [active] 931626002526 Predicted amidohydrolase [General function prediction only]; Region: COG0388 931626002527 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 931626002528 putative active site [active] 931626002529 catalytic triad [active] 931626002530 putative dimer interface [polypeptide binding]; other site 931626002531 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 931626002532 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 931626002533 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 931626002534 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 931626002535 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 931626002536 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 931626002537 active site 931626002538 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 931626002539 domain_subunit interface; other site 931626002540 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 931626002541 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 931626002542 active site 931626002543 FMN binding site [chemical binding]; other site 931626002544 substrate binding site [chemical binding]; other site 931626002545 3Fe-4S cluster binding site [ion binding]; other site 931626002546 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 931626002547 catalytic loop [active] 931626002548 iron binding site [ion binding]; other site 931626002549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931626002550 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626002551 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931626002552 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 931626002553 hydroxyglutarate oxidase; Provisional; Region: PRK11728 931626002554 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 931626002555 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 931626002556 homotrimer interaction site [polypeptide binding]; other site 931626002557 putative active site [active] 931626002558 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 931626002559 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 931626002560 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 931626002561 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 931626002562 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 931626002563 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 931626002564 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 931626002565 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 931626002566 NodB motif; other site 931626002567 active site 931626002568 catalytic site [active] 931626002569 Zn binding site [ion binding]; other site 931626002570 Predicted permeases [General function prediction only]; Region: COG0679 931626002571 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 931626002572 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626002573 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626002574 B12 binding site [chemical binding]; other site 931626002575 cobalt ligand [ion binding]; other site 931626002576 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 931626002577 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 931626002578 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 931626002579 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931626002580 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 931626002581 Domain of unknown function (DUF389); Region: DUF389; pfam04087 931626002582 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 931626002583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626002584 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 931626002585 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 931626002586 active site 931626002587 dimer interface [polypeptide binding]; other site 931626002588 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 931626002589 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 931626002590 active site 931626002591 FMN binding site [chemical binding]; other site 931626002592 substrate binding site [chemical binding]; other site 931626002593 3Fe-4S cluster binding site [ion binding]; other site 931626002594 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 931626002595 domain interface; other site 931626002596 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 931626002597 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626002598 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626002599 B12 binding site [chemical binding]; other site 931626002600 cobalt ligand [ion binding]; other site 931626002601 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626002602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626002603 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 931626002604 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 931626002605 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626002606 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626002607 Walker A/P-loop; other site 931626002608 ATP binding site [chemical binding]; other site 931626002609 Q-loop/lid; other site 931626002610 ABC transporter signature motif; other site 931626002611 Walker B; other site 931626002612 D-loop; other site 931626002613 H-loop/switch region; other site 931626002614 FtsX-like permease family; Region: FtsX; pfam02687 931626002615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626002616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626002617 active site 931626002618 phosphorylation site [posttranslational modification] 931626002619 intermolecular recognition site; other site 931626002620 dimerization interface [polypeptide binding]; other site 931626002621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626002622 DNA binding site [nucleotide binding] 931626002623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626002624 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 931626002625 dimer interface [polypeptide binding]; other site 931626002626 phosphorylation site [posttranslational modification] 931626002627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626002628 ATP binding site [chemical binding]; other site 931626002629 Mg2+ binding site [ion binding]; other site 931626002630 G-X-G motif; other site 931626002631 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 931626002632 active site 931626002633 catalytic residues [active] 931626002634 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626002635 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626002636 Clostridial hydrophobic W; Region: ChW; pfam07538 931626002637 Clostridial hydrophobic W; Region: ChW; pfam07538 931626002638 PAS domain; Region: PAS_9; pfam13426 931626002639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626002640 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 931626002641 Walker A motif; other site 931626002642 ATP binding site [chemical binding]; other site 931626002643 Walker B motif; other site 931626002644 arginine finger; other site 931626002645 tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979 931626002646 Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798 931626002647 BCCT family transporter; Region: BCCT; pfam02028 931626002648 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 931626002649 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626002650 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626002651 B12 binding site [chemical binding]; other site 931626002652 BCCT family transporter; Region: BCCT; pfam02028 931626002653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626002654 dimerization interface [polypeptide binding]; other site 931626002655 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626002656 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626002657 dimer interface [polypeptide binding]; other site 931626002658 putative CheW interface [polypeptide binding]; other site 931626002659 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 931626002660 active site 931626002661 FMN binding site [chemical binding]; other site 931626002662 substrate binding site [chemical binding]; other site 931626002663 3Fe-4S cluster binding site [ion binding]; other site 931626002664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626002665 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626002666 dimerization interface [polypeptide binding]; other site 931626002667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626002668 dimer interface [polypeptide binding]; other site 931626002669 phosphorylation site [posttranslational modification] 931626002670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626002671 ATP binding site [chemical binding]; other site 931626002672 Mg2+ binding site [ion binding]; other site 931626002673 G-X-G motif; other site 931626002674 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626002675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626002676 active site 931626002677 phosphorylation site [posttranslational modification] 931626002678 intermolecular recognition site; other site 931626002679 dimerization interface [polypeptide binding]; other site 931626002680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626002681 DNA binding site [nucleotide binding] 931626002682 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 931626002683 active site residue [active] 931626002684 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 931626002685 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 931626002686 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 931626002687 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626002688 catalytic residue [active] 931626002689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 931626002690 Domain of unknown function (DUF348); Region: DUF348; pfam03990 931626002691 3D domain; Region: 3D; cl01439 931626002692 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626002693 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 931626002694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626002695 DNA replication protein DnaC; Validated; Region: PRK06835 931626002696 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 931626002697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626002698 Walker A motif; other site 931626002699 ATP binding site [chemical binding]; other site 931626002700 Walker B motif; other site 931626002701 arginine finger; other site 931626002702 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 931626002703 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 931626002704 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 931626002705 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 931626002706 hinge; other site 931626002707 active site 931626002708 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 931626002709 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 931626002710 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 931626002711 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 931626002712 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 931626002713 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 931626002714 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931626002715 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 931626002716 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 931626002717 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931626002718 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 931626002719 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 931626002720 non-specific DNA interactions [nucleotide binding]; other site 931626002721 DNA binding site [nucleotide binding] 931626002722 sequence specific DNA binding site [nucleotide binding]; other site 931626002723 putative cAMP binding site [chemical binding]; other site 931626002724 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 931626002725 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 931626002726 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 931626002727 active site 931626002728 metal binding site [ion binding]; metal-binding site 931626002729 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 931626002730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626002731 active site 931626002732 motif I; other site 931626002733 motif II; other site 931626002734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626002735 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 931626002736 dimerization domain swap beta strand [polypeptide binding]; other site 931626002737 regulatory protein interface [polypeptide binding]; other site 931626002738 active site 931626002739 regulatory phosphorylation site [posttranslational modification]; other site 931626002740 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 931626002741 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 931626002742 non-specific DNA interactions [nucleotide binding]; other site 931626002743 DNA binding site [nucleotide binding] 931626002744 sequence specific DNA binding site [nucleotide binding]; other site 931626002745 putative cAMP binding site [chemical binding]; other site 931626002746 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 931626002747 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 931626002748 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 931626002749 putative N- and C-terminal domain interface [polypeptide binding]; other site 931626002750 putative active site [active] 931626002751 MgATP binding site [chemical binding]; other site 931626002752 catalytic site [active] 931626002753 metal binding site [ion binding]; metal-binding site 931626002754 putative xylulose binding site [chemical binding]; other site 931626002755 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 931626002756 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 931626002757 putative ligand binding site [chemical binding]; other site 931626002758 putative NAD binding site [chemical binding]; other site 931626002759 catalytic site [active] 931626002760 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 931626002761 intersubunit interface [polypeptide binding]; other site 931626002762 active site 931626002763 Zn2+ binding site [ion binding]; other site 931626002764 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 931626002765 active site 931626002766 catalytic residues [active] 931626002767 metal binding site [ion binding]; metal-binding site 931626002768 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 931626002769 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 931626002770 dimer interface [polypeptide binding]; other site 931626002771 [2Fe-2S] cluster binding site [ion binding]; other site 931626002772 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931626002773 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931626002774 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 931626002775 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626002776 FeS/SAM binding site; other site 931626002777 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 931626002778 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931626002779 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 931626002780 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931626002781 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 931626002782 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 931626002783 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 931626002784 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 931626002785 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931626002786 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 931626002787 Nitrogen regulatory protein P-II; Region: P-II; smart00938 931626002788 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 931626002789 nitrogenase iron protein; Region: nifH; TIGR01287 931626002790 Nucleotide-binding sites [chemical binding]; other site 931626002791 Walker A motif; other site 931626002792 Switch I region of nucleotide binding site; other site 931626002793 Fe4S4 binding sites [ion binding]; other site 931626002794 Switch II region of nucleotide binding site; other site 931626002795 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 931626002796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626002797 non-specific DNA binding site [nucleotide binding]; other site 931626002798 salt bridge; other site 931626002799 sequence-specific DNA binding site [nucleotide binding]; other site 931626002800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626002801 Radical SAM superfamily; Region: Radical_SAM; pfam04055 931626002802 FeS/SAM binding site; other site 931626002803 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 931626002804 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 931626002805 aspartate aminotransferase; Provisional; Region: PRK07568 931626002806 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626002807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626002808 homodimer interface [polypeptide binding]; other site 931626002809 catalytic residue [active] 931626002810 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 931626002811 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 931626002812 generic binding surface I; other site 931626002813 generic binding surface II; other site 931626002814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626002815 Zn2+ binding site [ion binding]; other site 931626002816 Mg2+ binding site [ion binding]; other site 931626002817 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 931626002818 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 931626002819 active site 931626002820 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 931626002821 active site 2 [active] 931626002822 active site 1 [active] 931626002823 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 931626002824 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 931626002825 Potassium binding sites [ion binding]; other site 931626002826 Cesium cation binding sites [ion binding]; other site 931626002827 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 931626002828 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 931626002829 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626002830 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626002831 B12 binding site [chemical binding]; other site 931626002832 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 931626002833 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626002834 DNA-binding site [nucleotide binding]; DNA binding site 931626002835 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 931626002836 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 931626002837 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 931626002838 Lamin Tail Domain; Region: LTD; pfam00932 931626002839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931626002840 ATP binding site [chemical binding]; other site 931626002841 putative Mg++ binding site [ion binding]; other site 931626002842 AAA domain; Region: AAA_12; pfam13087 931626002843 selenophosphate synthetase; Provisional; Region: PRK00943 931626002844 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 931626002845 dimerization interface [polypeptide binding]; other site 931626002846 putative ATP binding site [chemical binding]; other site 931626002847 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 931626002848 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 931626002849 dimer interface [polypeptide binding]; other site 931626002850 putative functional site; other site 931626002851 putative MPT binding site; other site 931626002852 MOSC domain; Region: MOSC; pfam03473 931626002853 selenocysteine synthase; Provisional; Region: PRK04311 931626002854 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 931626002855 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626002856 catalytic residue [active] 931626002857 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 931626002858 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 931626002859 G1 box; other site 931626002860 putative GEF interaction site [polypeptide binding]; other site 931626002861 GTP/Mg2+ binding site [chemical binding]; other site 931626002862 Switch I region; other site 931626002863 G2 box; other site 931626002864 G3 box; other site 931626002865 Switch II region; other site 931626002866 G4 box; other site 931626002867 G5 box; other site 931626002868 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 931626002869 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 931626002870 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 931626002871 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 931626002872 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626002873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626002874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 931626002875 dimerization interface [polypeptide binding]; other site 931626002876 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 931626002877 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 931626002878 [4Fe-4S] binding site [ion binding]; other site 931626002879 molybdopterin cofactor binding site; other site 931626002880 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 931626002881 molybdopterin cofactor binding site; other site 931626002882 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 931626002883 4Fe-4S binding domain; Region: Fer4; pfam00037 931626002884 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 931626002885 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 931626002886 [4Fe-4S] binding site [ion binding]; other site 931626002887 molybdopterin cofactor binding site; other site 931626002888 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 931626002889 molybdopterin cofactor binding site; other site 931626002890 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 931626002891 4Fe-4S binding domain; Region: Fer4; pfam00037 931626002892 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 931626002893 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 931626002894 4Fe-4S binding domain; Region: Fer4; cl02805 931626002895 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 931626002896 4Fe-4S binding domain; Region: Fer4; pfam00037 931626002897 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626002898 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 931626002899 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 931626002900 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 931626002901 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 931626002902 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 931626002903 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931626002904 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 931626002905 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931626002906 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626002907 catalytic residue [active] 931626002908 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 931626002909 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 931626002910 CPxP motif; other site 931626002911 DsrE/DsrF-like family; Region: DrsE; pfam02635 931626002912 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931626002913 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931626002914 active site 931626002915 FMN binding site [chemical binding]; other site 931626002916 substrate binding site [chemical binding]; other site 931626002917 putative catalytic residue [active] 931626002918 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626002919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626002920 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931626002921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931626002922 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931626002923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626002924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626002925 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 931626002926 endonuclease IV; Provisional; Region: PRK01060 931626002927 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 931626002928 AP (apurinic/apyrimidinic) site pocket; other site 931626002929 DNA interaction; other site 931626002930 Metal-binding active site; metal-binding site 931626002931 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626002932 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931626002933 dimerization interface [polypeptide binding]; other site 931626002934 putative DNA binding site [nucleotide binding]; other site 931626002935 putative Zn2+ binding site [ion binding]; other site 931626002936 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 931626002937 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 931626002938 metal-binding site [ion binding] 931626002939 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931626002940 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 931626002941 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 931626002942 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 931626002943 GTP binding site; other site 931626002944 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626002945 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626002946 B12 binding site [chemical binding]; other site 931626002947 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626002948 B12 binding site [chemical binding]; other site 931626002949 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 931626002950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626002951 DNA-binding site [nucleotide binding]; DNA binding site 931626002952 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 931626002953 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 931626002954 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 931626002955 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 931626002956 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931626002957 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931626002958 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 931626002959 putative catalytic site [active] 931626002960 putative metal binding site [ion binding]; other site 931626002961 putative phosphate binding site [ion binding]; other site 931626002962 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931626002963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626002964 Walker A/P-loop; other site 931626002965 ATP binding site [chemical binding]; other site 931626002966 Q-loop/lid; other site 931626002967 ABC transporter signature motif; other site 931626002968 Walker B; other site 931626002969 D-loop; other site 931626002970 H-loop/switch region; other site 931626002971 ABC transporter; Region: ABC_tran_2; pfam12848 931626002972 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626002973 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 931626002974 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 931626002975 trimer interface [polypeptide binding]; other site 931626002976 putative metal binding site [ion binding]; other site 931626002977 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 931626002978 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 931626002979 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931626002980 active site 931626002981 HIGH motif; other site 931626002982 nucleotide binding site [chemical binding]; other site 931626002983 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 931626002984 active site 931626002985 KMSKS motif; other site 931626002986 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 931626002987 tRNA binding surface [nucleotide binding]; other site 931626002988 anticodon binding site; other site 931626002989 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 931626002990 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 931626002991 flagellin; Provisional; Region: PRK12804 931626002992 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 931626002993 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 931626002994 Prephenate dehydratase; Region: PDT; pfam00800 931626002995 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 931626002996 putative L-Phe binding site [chemical binding]; other site 931626002997 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 931626002998 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 931626002999 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626003000 motif II; other site 931626003001 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 931626003002 Amidinotransferase; Region: Amidinotransf; cl12043 931626003003 ornithine carbamoyltransferase; Validated; Region: PRK02102 931626003004 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 931626003005 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 931626003006 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 931626003007 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 931626003008 active site 931626003009 substrate binding site [chemical binding]; other site 931626003010 metal binding site [ion binding]; metal-binding site 931626003011 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 931626003012 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931626003013 Walker A/P-loop; other site 931626003014 ATP binding site [chemical binding]; other site 931626003015 Q-loop/lid; other site 931626003016 ABC transporter signature motif; other site 931626003017 Walker B; other site 931626003018 D-loop; other site 931626003019 H-loop/switch region; other site 931626003020 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 931626003021 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 931626003022 Walker A/P-loop; other site 931626003023 ATP binding site [chemical binding]; other site 931626003024 Q-loop/lid; other site 931626003025 ABC transporter signature motif; other site 931626003026 Walker B; other site 931626003027 D-loop; other site 931626003028 H-loop/switch region; other site 931626003029 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 931626003030 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 931626003031 Helix-turn-helix domain; Region: HTH_18; pfam12833 931626003032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626003033 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626003034 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626003035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626003036 Walker A/P-loop; other site 931626003037 ATP binding site [chemical binding]; other site 931626003038 Q-loop/lid; other site 931626003039 ABC transporter signature motif; other site 931626003040 Walker B; other site 931626003041 D-loop; other site 931626003042 H-loop/switch region; other site 931626003043 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626003044 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626003045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626003046 Walker A/P-loop; other site 931626003047 ATP binding site [chemical binding]; other site 931626003048 Q-loop/lid; other site 931626003049 ABC transporter signature motif; other site 931626003050 Walker B; other site 931626003051 D-loop; other site 931626003052 H-loop/switch region; other site 931626003053 Transcriptional regulators [Transcription]; Region: FadR; COG2186 931626003054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626003055 DNA-binding site [nucleotide binding]; DNA binding site 931626003056 FCD domain; Region: FCD; pfam07729 931626003057 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 931626003058 Ligand binding site [chemical binding]; other site 931626003059 Electron transfer flavoprotein domain; Region: ETF; pfam01012 931626003060 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 931626003061 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 931626003062 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 931626003063 FAD binding domain; Region: FAD_binding_4; pfam01565 931626003064 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 931626003065 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 931626003066 L-lactate permease; Region: Lactate_perm; cl00701 931626003067 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 931626003068 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931626003069 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 931626003070 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626003071 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626003072 Walker A/P-loop; other site 931626003073 ATP binding site [chemical binding]; other site 931626003074 Q-loop/lid; other site 931626003075 ABC transporter signature motif; other site 931626003076 Walker B; other site 931626003077 D-loop; other site 931626003078 H-loop/switch region; other site 931626003079 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931626003080 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 931626003081 DNA binding residues [nucleotide binding] 931626003082 dimer interface [polypeptide binding]; other site 931626003083 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626003084 Clostridial hydrophobic W; Region: ChW; pfam07538 931626003085 Clostridial hydrophobic W; Region: ChW; pfam07538 931626003086 Clostridial hydrophobic W; Region: ChW; pfam07538 931626003087 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 931626003088 Cellulose binding domain; Region: CBM_2; cl17741 931626003089 HsdM N-terminal domain; Region: HsdM_N; pfam12161 931626003090 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 931626003091 Methyltransferase domain; Region: Methyltransf_26; pfam13659 931626003092 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 931626003093 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 931626003094 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 931626003095 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 931626003096 putative active site [active] 931626003097 putative NTP binding site [chemical binding]; other site 931626003098 putative nucleic acid binding site [nucleotide binding]; other site 931626003099 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 931626003100 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626003101 Zn2+ binding site [ion binding]; other site 931626003102 Mg2+ binding site [ion binding]; other site 931626003103 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 931626003104 Divergent AAA domain; Region: AAA_4; pfam04326 931626003105 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 931626003106 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 931626003107 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931626003108 ATP binding site [chemical binding]; other site 931626003109 putative Mg++ binding site [ion binding]; other site 931626003110 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 931626003111 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 931626003112 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 931626003113 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 931626003114 Beta-lactamase; Region: Beta-lactamase; pfam00144 931626003115 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 931626003116 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931626003117 Metal-binding active site; metal-binding site 931626003118 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 931626003119 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626003120 MarR family; Region: MarR_2; pfam12802 931626003121 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 931626003122 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 931626003123 NADP binding site [chemical binding]; other site 931626003124 dimer interface [polypeptide binding]; other site 931626003125 triosephosphate isomerase; Provisional; Region: PRK14565 931626003126 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 931626003127 substrate binding site [chemical binding]; other site 931626003128 dimer interface [polypeptide binding]; other site 931626003129 catalytic triad [active] 931626003130 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 931626003131 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 931626003132 dimerization domain swap beta strand [polypeptide binding]; other site 931626003133 regulatory protein interface [polypeptide binding]; other site 931626003134 active site 931626003135 regulatory phosphorylation site [posttranslational modification]; other site 931626003136 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 931626003137 PAS domain; Region: PAS; smart00091 931626003138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626003139 Walker A motif; other site 931626003140 ATP binding site [chemical binding]; other site 931626003141 Walker B motif; other site 931626003142 arginine finger; other site 931626003143 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 931626003144 active pocket/dimerization site; other site 931626003145 active site 931626003146 phosphorylation site [posttranslational modification] 931626003147 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 931626003148 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 931626003149 DAK2 domain; Region: Dak2; cl03685 931626003150 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 931626003151 active site 931626003152 catalytic triad [active] 931626003153 oxyanion hole [active] 931626003154 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 931626003155 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 931626003156 active site 931626003157 glycerol kinase; Provisional; Region: glpK; PRK00047 931626003158 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 931626003159 N- and C-terminal domain interface [polypeptide binding]; other site 931626003160 active site 931626003161 MgATP binding site [chemical binding]; other site 931626003162 catalytic site [active] 931626003163 metal binding site [ion binding]; metal-binding site 931626003164 glycerol binding site [chemical binding]; other site 931626003165 homotetramer interface [polypeptide binding]; other site 931626003166 homodimer interface [polypeptide binding]; other site 931626003167 FBP binding site [chemical binding]; other site 931626003168 protein IIAGlc interface [polypeptide binding]; other site 931626003169 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 931626003170 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 931626003171 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931626003172 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 931626003173 Soluble P-type ATPase [General function prediction only]; Region: COG4087 931626003174 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 931626003175 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626003176 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626003177 substrate binding pocket [chemical binding]; other site 931626003178 membrane-bound complex binding site; other site 931626003179 hinge residues; other site 931626003180 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 931626003181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626003182 dimer interface [polypeptide binding]; other site 931626003183 conserved gate region; other site 931626003184 putative PBP binding loops; other site 931626003185 ABC-ATPase subunit interface; other site 931626003186 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931626003187 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931626003188 Walker A/P-loop; other site 931626003189 ATP binding site [chemical binding]; other site 931626003190 Q-loop/lid; other site 931626003191 ABC transporter signature motif; other site 931626003192 Walker B; other site 931626003193 D-loop; other site 931626003194 H-loop/switch region; other site 931626003195 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 931626003196 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 931626003197 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 931626003198 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 931626003199 RPB1 interaction site [polypeptide binding]; other site 931626003200 RPB10 interaction site [polypeptide binding]; other site 931626003201 RPB11 interaction site [polypeptide binding]; other site 931626003202 RPB3 interaction site [polypeptide binding]; other site 931626003203 RPB12 interaction site [polypeptide binding]; other site 931626003204 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 931626003205 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 931626003206 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 931626003207 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 931626003208 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 931626003209 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 931626003210 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 931626003211 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 931626003212 G-loop; other site 931626003213 DNA binding site [nucleotide binding] 931626003214 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 931626003215 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 931626003216 S17 interaction site [polypeptide binding]; other site 931626003217 S8 interaction site; other site 931626003218 16S rRNA interaction site [nucleotide binding]; other site 931626003219 streptomycin interaction site [chemical binding]; other site 931626003220 23S rRNA interaction site [nucleotide binding]; other site 931626003221 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 931626003222 30S ribosomal protein S7; Validated; Region: PRK05302 931626003223 elongation factor G; Reviewed; Region: PRK00007 931626003224 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 931626003225 G1 box; other site 931626003226 putative GEF interaction site [polypeptide binding]; other site 931626003227 GTP/Mg2+ binding site [chemical binding]; other site 931626003228 Switch I region; other site 931626003229 G2 box; other site 931626003230 G3 box; other site 931626003231 Switch II region; other site 931626003232 G4 box; other site 931626003233 G5 box; other site 931626003234 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 931626003235 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 931626003236 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 931626003237 elongation factor Tu; Reviewed; Region: PRK00049 931626003238 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 931626003239 G1 box; other site 931626003240 GEF interaction site [polypeptide binding]; other site 931626003241 GTP/Mg2+ binding site [chemical binding]; other site 931626003242 Switch I region; other site 931626003243 G2 box; other site 931626003244 G3 box; other site 931626003245 Switch II region; other site 931626003246 G4 box; other site 931626003247 G5 box; other site 931626003248 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 931626003249 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 931626003250 Antibiotic Binding Site [chemical binding]; other site 931626003251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626003252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626003253 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 931626003254 MFS/sugar transport protein; Region: MFS_2; pfam13347 931626003255 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 931626003256 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 931626003257 transmembrane helices; other site 931626003258 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626003259 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626003260 B12 binding site [chemical binding]; other site 931626003261 cobalt ligand [ion binding]; other site 931626003262 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 931626003263 substrate binding pocket [chemical binding]; other site 931626003264 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 931626003265 dimer interface [polypeptide binding]; other site 931626003266 inhibitor binding site; inhibition site 931626003267 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 931626003268 Predicted dehydrogenase [General function prediction only]; Region: COG0579 931626003269 hydroxyglutarate oxidase; Provisional; Region: PRK11728 931626003270 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931626003271 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 931626003272 homodimer interface [polypeptide binding]; other site 931626003273 active site 931626003274 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 931626003275 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 931626003276 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 931626003277 Potassium binding sites [ion binding]; other site 931626003278 Cesium cation binding sites [ion binding]; other site 931626003279 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 931626003280 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 931626003281 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 931626003282 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 931626003283 homodimer interface [polypeptide binding]; other site 931626003284 NADP binding site [chemical binding]; other site 931626003285 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 931626003286 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 931626003287 SLBB domain; Region: SLBB; pfam10531 931626003288 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626003289 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 931626003290 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 931626003291 FAD binding site [chemical binding]; other site 931626003292 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 931626003293 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 931626003294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626003295 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 931626003296 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 931626003297 lipoyl attachment site [posttranslational modification]; other site 931626003298 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931626003299 active site 931626003300 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 931626003301 Uncharacterized conserved protein [Function unknown]; Region: COG1615 931626003302 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 931626003303 seryl-tRNA synthetase; Provisional; Region: PRK05431 931626003304 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 931626003305 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 931626003306 dimer interface [polypeptide binding]; other site 931626003307 active site 931626003308 motif 1; other site 931626003309 motif 2; other site 931626003310 motif 3; other site 931626003311 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 931626003312 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 931626003313 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 931626003314 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 931626003315 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 931626003316 dimer interface [polypeptide binding]; other site 931626003317 putative anticodon binding site; other site 931626003318 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 931626003319 motif 1; other site 931626003320 active site 931626003321 motif 2; other site 931626003322 motif 3; other site 931626003323 LytTr DNA-binding domain; Region: LytTR; pfam04397 931626003324 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 931626003325 CAAX protease self-immunity; Region: Abi; pfam02517 931626003326 Transposase domain (DUF772); Region: DUF772; pfam05598 931626003327 Dienelactone hydrolase family; Region: DLH; pfam01738 931626003328 NAD-dependent deacetylase; Provisional; Region: PRK00481 931626003329 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 931626003330 Uncharacterized conserved protein [Function unknown]; Region: COG1915 931626003331 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 931626003332 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 931626003333 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 931626003334 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 931626003335 mraZ protein; Region: TIGR00242 931626003336 MraZ protein; Region: MraZ; pfam02381 931626003337 MraZ protein; Region: MraZ; pfam02381 931626003338 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 931626003339 MraW methylase family; Region: Methyltransf_5; pfam01795 931626003340 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 931626003341 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 931626003342 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 931626003343 PASTA domain; Region: PASTA; smart00740 931626003344 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 931626003345 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 931626003346 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 931626003347 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931626003348 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931626003349 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 931626003350 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 931626003351 Mg++ binding site [ion binding]; other site 931626003352 putative catalytic motif [active] 931626003353 putative substrate binding site [chemical binding]; other site 931626003354 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 931626003355 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 931626003356 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931626003357 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931626003358 cell division protein FtsW; Region: ftsW; TIGR02614 931626003359 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 931626003360 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 931626003361 active site 931626003362 homodimer interface [polypeptide binding]; other site 931626003363 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 931626003364 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 931626003365 cell division protein FtsZ; Validated; Region: PRK09330 931626003366 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 931626003367 nucleotide binding site [chemical binding]; other site 931626003368 SulA interaction site; other site 931626003369 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 931626003370 ATP cone domain; Region: ATP-cone; pfam03477 931626003371 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 931626003372 dimer interface [polypeptide binding]; other site 931626003373 ADP-ribose binding site [chemical binding]; other site 931626003374 active site 931626003375 nudix motif; other site 931626003376 metal binding site [ion binding]; metal-binding site 931626003377 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 931626003378 Peptidase family M50; Region: Peptidase_M50; pfam02163 931626003379 active site 931626003380 putative substrate binding region [chemical binding]; other site 931626003381 ScpA/B protein; Region: ScpA_ScpB; cl00598 931626003382 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 931626003383 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 931626003384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931626003385 RNA binding surface [nucleotide binding]; other site 931626003386 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 931626003387 active site 931626003388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931626003389 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931626003390 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 931626003391 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 931626003392 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 931626003393 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 931626003394 putative active site [active] 931626003395 flavoprotein, HI0933 family; Region: TIGR00275 931626003396 cytidylate kinase; Provisional; Region: cmk; PRK00023 931626003397 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 931626003398 CMP-binding site; other site 931626003399 The sites determining sugar specificity; other site 931626003400 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 931626003401 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 931626003402 putative acyl-acceptor binding pocket; other site 931626003403 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 931626003404 LytB protein; Region: LYTB; cl00507 931626003405 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 931626003406 RNA binding site [nucleotide binding]; other site 931626003407 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 931626003408 RNA binding site [nucleotide binding]; other site 931626003409 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 931626003410 RNA binding site [nucleotide binding]; other site 931626003411 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 931626003412 RNA binding site [nucleotide binding]; other site 931626003413 domain interface; other site 931626003414 Transcriptional regulator; Region: Rrf2; cl17282 931626003415 Rrf2 family protein; Region: rrf2_super; TIGR00738 931626003416 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 931626003417 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 931626003418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626003419 catalytic residue [active] 931626003420 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 931626003421 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 931626003422 trimerization site [polypeptide binding]; other site 931626003423 active site 931626003424 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 931626003425 Domain of unknown function DUF20; Region: UPF0118; pfam01594 931626003426 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 931626003427 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 931626003428 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 931626003429 motif 1; other site 931626003430 active site 931626003431 motif 2; other site 931626003432 motif 3; other site 931626003433 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 931626003434 hypothetical protein; Provisional; Region: PRK05473 931626003435 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931626003436 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 931626003437 active site 931626003438 catalytic tetrad [active] 931626003439 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626003440 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626003441 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 931626003442 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 931626003443 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 931626003444 metal binding site 2 [ion binding]; metal-binding site 931626003445 putative DNA binding helix; other site 931626003446 metal binding site 1 [ion binding]; metal-binding site 931626003447 dimer interface [polypeptide binding]; other site 931626003448 structural Zn2+ binding site [ion binding]; other site 931626003449 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 931626003450 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931626003451 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 931626003452 Protein of unknown function (DUF964); Region: DUF964; pfam06133 931626003453 YceG-like family; Region: YceG; pfam02618 931626003454 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 931626003455 dimerization interface [polypeptide binding]; other site 931626003456 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 931626003457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626003458 S-adenosylmethionine binding site [chemical binding]; other site 931626003459 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 931626003460 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 931626003461 Peptidase family U32; Region: Peptidase_U32; pfam01136 931626003462 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 931626003463 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 931626003464 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 931626003465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626003466 active site 931626003467 phosphorylation site [posttranslational modification] 931626003468 intermolecular recognition site; other site 931626003469 dimerization interface [polypeptide binding]; other site 931626003470 LytTr DNA-binding domain; Region: LytTR; pfam04397 931626003471 CAAX protease self-immunity; Region: Abi; pfam02517 931626003472 putative transposase OrfB; Reviewed; Region: PHA02517 931626003473 HTH-like domain; Region: HTH_21; pfam13276 931626003474 Integrase core domain; Region: rve; pfam00665 931626003475 Integrase core domain; Region: rve_3; pfam13683 931626003476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931626003477 Transposase; Region: HTH_Tnp_1; pfam01527 931626003478 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626003479 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626003480 Walker A/P-loop; other site 931626003481 ATP binding site [chemical binding]; other site 931626003482 Q-loop/lid; other site 931626003483 ABC transporter signature motif; other site 931626003484 Walker B; other site 931626003485 D-loop; other site 931626003486 H-loop/switch region; other site 931626003487 Response regulator receiver domain; Region: Response_reg; pfam00072 931626003488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626003489 active site 931626003490 phosphorylation site [posttranslational modification] 931626003491 intermolecular recognition site; other site 931626003492 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 931626003493 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 931626003494 Ion channel; Region: Ion_trans_2; pfam07885 931626003495 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 931626003496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931626003497 active site 931626003498 metal binding site [ion binding]; metal-binding site 931626003499 DNA binding site [nucleotide binding] 931626003500 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 931626003501 exonuclease SbcC; Region: sbcc; TIGR00618 931626003502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626003503 Walker A/P-loop; other site 931626003504 ATP binding site [chemical binding]; other site 931626003505 Q-loop/lid; other site 931626003506 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 931626003507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626003508 ABC transporter signature motif; other site 931626003509 Walker B; other site 931626003510 D-loop; other site 931626003511 H-loop/switch region; other site 931626003512 Protein of unknown function DUF45; Region: DUF45; pfam01863 931626003513 Predicted transcriptional regulators [Transcription]; Region: COG1725 931626003514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626003515 DNA-binding site [nucleotide binding]; DNA binding site 931626003516 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626003517 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626003518 Walker A/P-loop; other site 931626003519 ATP binding site [chemical binding]; other site 931626003520 Q-loop/lid; other site 931626003521 ABC transporter signature motif; other site 931626003522 Walker B; other site 931626003523 D-loop; other site 931626003524 H-loop/switch region; other site 931626003525 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 931626003526 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 931626003527 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 931626003528 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 931626003529 4Fe-4S binding domain; Region: Fer4; pfam00037 931626003530 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 931626003531 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626003532 Walker A/P-loop; other site 931626003533 ATP binding site [chemical binding]; other site 931626003534 Q-loop/lid; other site 931626003535 ABC transporter signature motif; other site 931626003536 Walker B; other site 931626003537 D-loop; other site 931626003538 H-loop/switch region; other site 931626003539 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 931626003540 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 931626003541 catalytic residues [active] 931626003542 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 931626003543 methionine sulfoxide reductase B; Provisional; Region: PRK00222 931626003544 SelR domain; Region: SelR; pfam01641 931626003545 Uncharacterized conserved protein [Function unknown]; Region: COG1633 931626003546 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 931626003547 diiron binding motif [ion binding]; other site 931626003548 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 931626003549 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 931626003550 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 931626003551 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 931626003552 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931626003553 Walker A/P-loop; other site 931626003554 ATP binding site [chemical binding]; other site 931626003555 Q-loop/lid; other site 931626003556 ABC transporter signature motif; other site 931626003557 Walker B; other site 931626003558 D-loop; other site 931626003559 H-loop/switch region; other site 931626003560 cobalt transport protein CbiM; Validated; Region: PRK08319 931626003561 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 931626003562 cobalt transport protein CbiN; Provisional; Region: PRK02898 931626003563 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 931626003564 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 931626003565 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931626003566 ABC-ATPase subunit interface; other site 931626003567 dimer interface [polypeptide binding]; other site 931626003568 putative PBP binding regions; other site 931626003569 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 931626003570 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 931626003571 Walker A/P-loop; other site 931626003572 ATP binding site [chemical binding]; other site 931626003573 Q-loop/lid; other site 931626003574 ABC transporter signature motif; other site 931626003575 Walker B; other site 931626003576 D-loop; other site 931626003577 H-loop/switch region; other site 931626003578 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 931626003579 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 931626003580 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 931626003581 intersubunit interface [polypeptide binding]; other site 931626003582 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 931626003583 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 931626003584 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 931626003585 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 931626003586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626003587 Walker A motif; other site 931626003588 ATP binding site [chemical binding]; other site 931626003589 Walker B motif; other site 931626003590 arginine finger; other site 931626003591 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 931626003592 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 931626003593 metal ion-dependent adhesion site (MIDAS); other site 931626003594 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 931626003595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626003596 Walker A motif; other site 931626003597 ATP binding site [chemical binding]; other site 931626003598 Walker B motif; other site 931626003599 arginine finger; other site 931626003600 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 931626003601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626003602 FeS/SAM binding site; other site 931626003603 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 931626003604 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 931626003605 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 931626003606 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 931626003607 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 931626003608 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626003609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626003610 Walker A/P-loop; other site 931626003611 ATP binding site [chemical binding]; other site 931626003612 Q-loop/lid; other site 931626003613 ABC transporter signature motif; other site 931626003614 Walker B; other site 931626003615 D-loop; other site 931626003616 H-loop/switch region; other site 931626003617 ABC-2 type transporter; Region: ABC2_membrane; cl17235 931626003618 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931626003619 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 931626003620 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 931626003621 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 931626003622 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 931626003623 Precorrin-8X methylmutase; Region: CbiC; pfam02570 931626003624 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 931626003625 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 931626003626 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 931626003627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626003628 dimer interface [polypeptide binding]; other site 931626003629 conserved gate region; other site 931626003630 putative PBP binding loops; other site 931626003631 ABC-ATPase subunit interface; other site 931626003632 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 931626003633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626003634 Walker A/P-loop; other site 931626003635 ATP binding site [chemical binding]; other site 931626003636 Q-loop/lid; other site 931626003637 ABC transporter signature motif; other site 931626003638 Walker B; other site 931626003639 D-loop; other site 931626003640 H-loop/switch region; other site 931626003641 Heavy-metal-associated domain; Region: HMA; pfam00403 931626003642 metal-binding site [ion binding] 931626003643 molybdenum transport protein ModD; Provisional; Region: PRK06096 931626003644 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 931626003645 dimerization interface [polypeptide binding]; other site 931626003646 active site 931626003647 Uncharacterized conserved protein [Function unknown]; Region: COG2128 931626003648 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 931626003649 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931626003650 dimerization interface [polypeptide binding]; other site 931626003651 putative DNA binding site [nucleotide binding]; other site 931626003652 putative Zn2+ binding site [ion binding]; other site 931626003653 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 931626003654 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626003655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626003656 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 931626003657 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 931626003658 active site residue [active] 931626003659 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 931626003660 CPxP motif; other site 931626003661 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 931626003662 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 931626003663 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 931626003664 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 931626003665 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 931626003666 DNA binding residues [nucleotide binding] 931626003667 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 931626003668 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 931626003669 Hexamer interface [polypeptide binding]; other site 931626003670 Hexagonal pore residue; other site 931626003671 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 931626003672 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 931626003673 P loop nucleotide binding; other site 931626003674 switch II; other site 931626003675 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 931626003676 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 931626003677 P loop nucleotide binding; other site 931626003678 switch II; other site 931626003679 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 931626003680 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 931626003681 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 931626003682 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 931626003683 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 931626003684 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 931626003685 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 931626003686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626003687 S-adenosylmethionine binding site [chemical binding]; other site 931626003688 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 931626003689 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 931626003690 putative metal binding site [ion binding]; other site 931626003691 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 931626003692 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931626003693 ABC-ATPase subunit interface; other site 931626003694 dimer interface [polypeptide binding]; other site 931626003695 putative PBP binding regions; other site 931626003696 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 931626003697 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 931626003698 Walker A/P-loop; other site 931626003699 ATP binding site [chemical binding]; other site 931626003700 Q-loop/lid; other site 931626003701 ABC transporter signature motif; other site 931626003702 Walker B; other site 931626003703 D-loop; other site 931626003704 H-loop/switch region; other site 931626003705 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 931626003706 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931626003707 ligand binding site [chemical binding]; other site 931626003708 flexible hinge region; other site 931626003709 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 931626003710 4Fe-4S binding domain; Region: Fer4_6; pfam12837 931626003711 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626003712 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 931626003713 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 931626003714 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 931626003715 P-loop; other site 931626003716 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626003717 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 931626003718 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931626003719 catalytic loop [active] 931626003720 iron binding site [ion binding]; other site 931626003721 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931626003722 nucleotide binding site [chemical binding]; other site 931626003723 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 931626003724 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 931626003725 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 931626003726 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 931626003727 Putative Fe-S cluster; Region: FeS; pfam04060 931626003728 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 931626003729 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 931626003730 substrate binding pocket [chemical binding]; other site 931626003731 dimer interface [polypeptide binding]; other site 931626003732 inhibitor binding site; inhibition site 931626003733 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 931626003734 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626003735 ACS interaction site; other site 931626003736 CODH interaction site; other site 931626003737 metal cluster binding site [ion binding]; other site 931626003738 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 931626003739 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 931626003740 P-loop; other site 931626003741 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626003742 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 931626003743 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626003744 ACS interaction site; other site 931626003745 CODH interaction site; other site 931626003746 metal cluster binding site [ion binding]; other site 931626003747 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 931626003748 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 931626003749 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 931626003750 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 931626003751 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 931626003752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626003753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931626003754 Coenzyme A binding pocket [chemical binding]; other site 931626003755 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 931626003756 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 931626003757 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 931626003758 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 931626003759 putative homodimer interface [polypeptide binding]; other site 931626003760 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 931626003761 heterodimer interface [polypeptide binding]; other site 931626003762 homodimer interface [polypeptide binding]; other site 931626003763 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 931626003764 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 931626003765 23S rRNA interface [nucleotide binding]; other site 931626003766 L7/L12 interface [polypeptide binding]; other site 931626003767 putative thiostrepton binding site; other site 931626003768 L25 interface [polypeptide binding]; other site 931626003769 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 931626003770 mRNA/rRNA interface [nucleotide binding]; other site 931626003771 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 931626003772 23S rRNA interface [nucleotide binding]; other site 931626003773 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 931626003774 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 931626003775 core dimer interface [polypeptide binding]; other site 931626003776 peripheral dimer interface [polypeptide binding]; other site 931626003777 L10 interface [polypeptide binding]; other site 931626003778 L11 interface [polypeptide binding]; other site 931626003779 putative EF-Tu interaction site [polypeptide binding]; other site 931626003780 putative EF-G interaction site [polypeptide binding]; other site 931626003781 prolyl-tRNA synthetase; Provisional; Region: PRK08661 931626003782 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 931626003783 dimer interface [polypeptide binding]; other site 931626003784 motif 1; other site 931626003785 active site 931626003786 motif 2; other site 931626003787 motif 3; other site 931626003788 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 931626003789 anticodon binding site; other site 931626003790 zinc-binding site [ion binding]; other site 931626003791 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 931626003792 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 931626003793 homooctamer interface [polypeptide binding]; other site 931626003794 active site 931626003795 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 931626003796 catalytic center binding site [active] 931626003797 ATP binding site [chemical binding]; other site 931626003798 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 931626003799 dihydropteroate synthase; Region: DHPS; TIGR01496 931626003800 substrate binding pocket [chemical binding]; other site 931626003801 dimer interface [polypeptide binding]; other site 931626003802 inhibitor binding site; inhibition site 931626003803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626003804 Zn2+ binding site [ion binding]; other site 931626003805 Mg2+ binding site [ion binding]; other site 931626003806 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 931626003807 GTP cyclohydrolase I; Provisional; Region: PLN03044 931626003808 active site 931626003809 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 931626003810 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 931626003811 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 931626003812 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 931626003813 Protein of unknown function DUF45; Region: DUF45; pfam01863 931626003814 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 931626003815 S-ribosylhomocysteinase; Provisional; Region: PRK02260 931626003816 Recombination protein U; Region: RecU; pfam03838 931626003817 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 931626003818 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931626003819 RNA binding surface [nucleotide binding]; other site 931626003820 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 931626003821 active site 931626003822 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 931626003823 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 931626003824 intersubunit interface [polypeptide binding]; other site 931626003825 active site 931626003826 zinc binding site [ion binding]; other site 931626003827 Na+ binding site [ion binding]; other site 931626003828 hypothetical protein; Provisional; Region: PRK09609 931626003829 Rubredoxin [Energy production and conversion]; Region: COG1773 931626003830 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 931626003831 iron binding site [ion binding]; other site 931626003832 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 931626003833 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931626003834 active site 931626003835 DNA binding site [nucleotide binding] 931626003836 Int/Topo IB signature motif; other site 931626003837 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626003838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626003839 non-specific DNA binding site [nucleotide binding]; other site 931626003840 salt bridge; other site 931626003841 sequence-specific DNA binding site [nucleotide binding]; other site 931626003842 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 931626003843 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 931626003844 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 931626003845 P-loop; other site 931626003846 Magnesium ion binding site [ion binding]; other site 931626003847 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 931626003848 Magnesium ion binding site [ion binding]; other site 931626003849 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 931626003850 ParB-like nuclease domain; Region: ParB; smart00470 931626003851 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 931626003852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626003853 non-specific DNA binding site [nucleotide binding]; other site 931626003854 salt bridge; other site 931626003855 sequence-specific DNA binding site [nucleotide binding]; other site 931626003856 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 931626003857 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 931626003858 dimer interface [polypeptide binding]; other site 931626003859 ssDNA binding site [nucleotide binding]; other site 931626003860 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931626003861 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 931626003862 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 931626003863 active site 931626003864 metal binding site [ion binding]; metal-binding site 931626003865 interdomain interaction site; other site 931626003866 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 931626003867 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 931626003868 Walker A motif; other site 931626003869 ATP binding site [chemical binding]; other site 931626003870 Walker B motif; other site 931626003871 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 931626003872 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 931626003873 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 931626003874 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 931626003875 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 931626003876 Walker A motif; other site 931626003877 ATP binding site [chemical binding]; other site 931626003878 Walker B motif; other site 931626003879 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 931626003880 Fic/DOC family; Region: Fic; pfam02661 931626003881 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 931626003882 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 931626003883 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 931626003884 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 931626003885 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 931626003886 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 931626003887 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 931626003888 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 931626003889 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626003890 AAA-like domain; Region: AAA_10; pfam12846 931626003891 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 931626003892 AAA domain; Region: AAA_31; pfam13614 931626003893 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 931626003894 Peptidase family M23; Region: Peptidase_M23; pfam01551 931626003895 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 931626003896 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626003897 Domain of unknown function (DUF955); Region: DUF955; cl01076 931626003898 Fic/DOC family; Region: Fic; pfam02661 931626003899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626003900 Zn2+ binding site [ion binding]; other site 931626003901 Mg2+ binding site [ion binding]; other site 931626003902 Methyltransferase domain; Region: Methyltransf_26; pfam13659 931626003903 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 931626003904 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 931626003905 DEAD-like helicases superfamily; Region: DEXDc; smart00487 931626003906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 931626003907 ATP binding site [chemical binding]; other site 931626003908 putative Mg++ binding site [ion binding]; other site 931626003909 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 931626003910 helicase superfamily c-terminal domain; Region: HELICc; smart00490 931626003911 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 931626003912 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 931626003913 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 931626003914 putative active site [active] 931626003915 putative NTP binding site [chemical binding]; other site 931626003916 putative nucleic acid binding site [nucleotide binding]; other site 931626003917 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 931626003918 DNA polymerase IV; Reviewed; Region: PRK03103 931626003919 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 931626003920 active site 931626003921 DNA binding site [nucleotide binding] 931626003922 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 931626003923 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626003924 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626003925 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626003926 Clostridial hydrophobic W; Region: ChW; pfam07538 931626003927 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 931626003928 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 931626003929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626003930 Walker A motif; other site 931626003931 ATP binding site [chemical binding]; other site 931626003932 Walker B motif; other site 931626003933 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 931626003934 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 931626003935 Integrase core domain; Region: rve; pfam00665 931626003936 Integrase core domain; Region: rve_3; pfam13683 931626003937 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 931626003938 Transposase; Region: DDE_Tnp_ISL3; pfam01610 931626003939 Transposase; Region: DDE_Tnp_ISL3; pfam01610 931626003940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 931626003941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626003942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626003943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 931626003944 dimerization interface [polypeptide binding]; other site 931626003945 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626003946 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 931626003947 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 931626003948 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626003949 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 931626003950 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 931626003951 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626003952 Ferredoxin [Energy production and conversion]; Region: COG1146 931626003953 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 931626003954 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 931626003955 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 931626003956 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626003957 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626003958 B12 binding site [chemical binding]; other site 931626003959 cobalt ligand [ion binding]; other site 931626003960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626003961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626003962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626003963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626003964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931626003965 dimerization interface [polypeptide binding]; other site 931626003966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931626003967 NmrA-like family; Region: NmrA; pfam05368 931626003968 NAD(P) binding site [chemical binding]; other site 931626003969 active site 931626003970 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 931626003971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626003972 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 931626003973 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 931626003974 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 931626003975 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 931626003976 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 931626003977 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 931626003978 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 931626003979 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626003980 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 931626003981 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 931626003982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626003983 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931626003984 putative substrate translocation pore; other site 931626003985 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 931626003986 putative MPT binding site; other site 931626003987 PAS fold; Region: PAS_4; pfam08448 931626003988 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626003989 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626003990 dimer interface [polypeptide binding]; other site 931626003991 putative CheW interface [polypeptide binding]; other site 931626003992 MarR family; Region: MarR_2; pfam12802 931626003993 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626003994 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626003995 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626003996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626003997 Walker A/P-loop; other site 931626003998 ATP binding site [chemical binding]; other site 931626003999 Q-loop/lid; other site 931626004000 ABC transporter signature motif; other site 931626004001 Walker B; other site 931626004002 D-loop; other site 931626004003 H-loop/switch region; other site 931626004004 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626004005 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626004006 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 931626004007 Walker A/P-loop; other site 931626004008 ATP binding site [chemical binding]; other site 931626004009 Q-loop/lid; other site 931626004010 ABC transporter signature motif; other site 931626004011 Walker B; other site 931626004012 D-loop; other site 931626004013 H-loop/switch region; other site 931626004014 AAA domain; Region: AAA_21; pfam13304 931626004015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626004016 ABC transporter signature motif; other site 931626004017 Walker B; other site 931626004018 D-loop; other site 931626004019 H-loop/switch region; other site 931626004020 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 931626004021 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 931626004022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626004023 Walker A motif; other site 931626004024 ATP binding site [chemical binding]; other site 931626004025 Walker B motif; other site 931626004026 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 931626004027 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 931626004028 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 931626004029 Int/Topo IB signature motif; other site 931626004030 Domain of unknown function (DUF955); Region: DUF955; pfam06114 931626004031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626004032 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 931626004033 Walker A motif; other site 931626004034 ATP binding site [chemical binding]; other site 931626004035 Walker B motif; other site 931626004036 arginine finger; other site 931626004037 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 931626004038 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 931626004039 active site 931626004040 catalytic triad [active] 931626004041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626004042 DNA-binding site [nucleotide binding]; DNA binding site 931626004043 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 931626004044 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626004045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626004046 homodimer interface [polypeptide binding]; other site 931626004047 catalytic residue [active] 931626004048 4-aminobutyrate aminotransferase; Provisional; Region: PRK08360 931626004049 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931626004050 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931626004051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626004052 catalytic residue [active] 931626004053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626004054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626004055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931626004056 dimerization interface [polypeptide binding]; other site 931626004057 short chain dehydrogenase; Provisional; Region: PRK06172 931626004058 classical (c) SDRs; Region: SDR_c; cd05233 931626004059 NAD(P) binding site [chemical binding]; other site 931626004060 active site 931626004061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626004062 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626004063 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626004064 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 931626004065 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 931626004066 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 931626004067 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626004068 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 931626004069 Walker A/P-loop; other site 931626004070 ATP binding site [chemical binding]; other site 931626004071 Q-loop/lid; other site 931626004072 ABC transporter signature motif; other site 931626004073 Walker B; other site 931626004074 D-loop; other site 931626004075 H-loop/switch region; other site 931626004076 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626004077 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626004078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626004079 Walker A/P-loop; other site 931626004080 ATP binding site [chemical binding]; other site 931626004081 Q-loop/lid; other site 931626004082 ABC transporter signature motif; other site 931626004083 Walker B; other site 931626004084 D-loop; other site 931626004085 H-loop/switch region; other site 931626004086 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931626004087 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 931626004088 DNA binding residues [nucleotide binding] 931626004089 dimer interface [polypeptide binding]; other site 931626004090 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 931626004091 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 931626004092 active site 931626004093 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 931626004094 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 931626004095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626004096 UDP-galactopyranose mutase; Region: GLF; pfam03275 931626004097 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 931626004098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931626004099 active site 931626004100 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 931626004101 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 931626004102 phenylhydantoinase; Validated; Region: PRK08323 931626004103 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 931626004104 tetramer interface [polypeptide binding]; other site 931626004105 active site 931626004106 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 931626004107 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 931626004108 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 931626004109 peptidase; Reviewed; Region: PRK13004 931626004110 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 931626004111 putative metal binding site [ion binding]; other site 931626004112 putative dimer interface [polypeptide binding]; other site 931626004113 carbamate kinase; Reviewed; Region: PRK12686 931626004114 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 931626004115 putative substrate binding site [chemical binding]; other site 931626004116 nucleotide binding site [chemical binding]; other site 931626004117 nucleotide binding site [chemical binding]; other site 931626004118 homodimer interface [polypeptide binding]; other site 931626004119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 931626004120 YheO-like PAS domain; Region: PAS_6; pfam08348 931626004121 HTH domain; Region: HTH_22; pfam13309 931626004122 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 931626004123 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 931626004124 catalytic residue [active] 931626004125 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 931626004126 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 931626004127 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 931626004128 metal binding site [ion binding]; metal-binding site 931626004129 dimer interface [polypeptide binding]; other site 931626004130 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 931626004131 Ligand binding site; other site 931626004132 metal-binding site 931626004133 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 931626004134 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 931626004135 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 931626004136 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 931626004137 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 931626004138 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 931626004139 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 931626004140 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 931626004141 putative metal binding residues [ion binding]; other site 931626004142 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 931626004143 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 931626004144 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 931626004145 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931626004146 ABC-ATPase subunit interface; other site 931626004147 dimer interface [polypeptide binding]; other site 931626004148 putative PBP binding regions; other site 931626004149 ferric uptake regulator; Provisional; Region: fur; PRK09462 931626004150 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 931626004151 metal binding site 2 [ion binding]; metal-binding site 931626004152 putative DNA binding helix; other site 931626004153 metal binding site 1 [ion binding]; metal-binding site 931626004154 dimer interface [polypeptide binding]; other site 931626004155 structural Zn2+ binding site [ion binding]; other site 931626004156 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931626004157 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 931626004158 active site 931626004159 catalytic tetrad [active] 931626004160 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931626004161 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 931626004162 classical (c) SDRs; Region: SDR_c; cd05233 931626004163 NAD(P) binding site [chemical binding]; other site 931626004164 active site 931626004165 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 931626004166 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 931626004167 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 931626004168 transketolase; Reviewed; Region: PRK05899 931626004169 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 931626004170 TPP-binding site [chemical binding]; other site 931626004171 dimer interface [polypeptide binding]; other site 931626004172 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 931626004173 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931626004174 PYR/PP interface [polypeptide binding]; other site 931626004175 dimer interface [polypeptide binding]; other site 931626004176 TPP binding site [chemical binding]; other site 931626004177 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931626004178 Class I aldolases; Region: Aldolase_Class_I; cl17187 931626004179 catalytic residue [active] 931626004180 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 931626004181 intersubunit interface [polypeptide binding]; other site 931626004182 active site 931626004183 zinc binding site [ion binding]; other site 931626004184 Na+ binding site [ion binding]; other site 931626004185 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 931626004186 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 931626004187 tetramer interface [polypeptide binding]; other site 931626004188 TPP-binding site [chemical binding]; other site 931626004189 heterodimer interface [polypeptide binding]; other site 931626004190 phosphorylation loop region [posttranslational modification] 931626004191 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 931626004192 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 931626004193 alpha subunit interface [polypeptide binding]; other site 931626004194 TPP binding site [chemical binding]; other site 931626004195 heterodimer interface [polypeptide binding]; other site 931626004196 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931626004197 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 931626004198 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 931626004199 E3 interaction surface; other site 931626004200 lipoyl attachment site [posttranslational modification]; other site 931626004201 e3 binding domain; Region: E3_binding; pfam02817 931626004202 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 931626004203 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 931626004204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626004205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626004206 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 931626004207 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 931626004208 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 931626004209 glycerol kinase; Provisional; Region: glpK; PRK00047 931626004210 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 931626004211 N- and C-terminal domain interface [polypeptide binding]; other site 931626004212 active site 931626004213 MgATP binding site [chemical binding]; other site 931626004214 catalytic site [active] 931626004215 metal binding site [ion binding]; metal-binding site 931626004216 glycerol binding site [chemical binding]; other site 931626004217 homotetramer interface [polypeptide binding]; other site 931626004218 homodimer interface [polypeptide binding]; other site 931626004219 FBP binding site [chemical binding]; other site 931626004220 protein IIAGlc interface [polypeptide binding]; other site 931626004221 Predicted dehydrogenase [General function prediction only]; Region: COG0579 931626004222 hydroxyglutarate oxidase; Provisional; Region: PRK11728 931626004223 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931626004224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931626004225 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 931626004226 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 931626004227 intersubunit interface [polypeptide binding]; other site 931626004228 active site 931626004229 zinc binding site [ion binding]; other site 931626004230 Na+ binding site [ion binding]; other site 931626004231 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 931626004232 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 931626004233 active site 931626004234 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 931626004235 phosphoglycolate phosphatase; Provisional; Region: PRK13222 931626004236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626004237 motif II; other site 931626004238 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 931626004239 intersubunit interface [polypeptide binding]; other site 931626004240 active site 931626004241 catalytic residue [active] 931626004242 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 931626004243 catalytic residue [active] 931626004244 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 931626004245 intersubunit interface [polypeptide binding]; other site 931626004246 active site 931626004247 catalytic residue [active] 931626004248 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 931626004249 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 931626004250 N- and C-terminal domain interface [polypeptide binding]; other site 931626004251 putative active site [active] 931626004252 MgATP binding site [chemical binding]; other site 931626004253 catalytic site [active] 931626004254 metal binding site [ion binding]; metal-binding site 931626004255 putative xylulose binding site [chemical binding]; other site 931626004256 putative homodimer interface [polypeptide binding]; other site 931626004257 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 931626004258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626004259 DNA-binding site [nucleotide binding]; DNA binding site 931626004260 UTRA domain; Region: UTRA; pfam07702 931626004261 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 931626004262 DHHW protein; Region: DHHW; pfam14286 931626004263 DHHW protein; Region: DHHW; pfam14286 931626004264 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 931626004265 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 931626004266 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 931626004267 active site 931626004268 catalytic triad [active] 931626004269 oxyanion hole [active] 931626004270 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 931626004271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931626004272 Predicted dehydrogenase [General function prediction only]; Region: COG0579 931626004273 hydroxyglutarate oxidase; Provisional; Region: PRK11728 931626004274 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931626004275 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 931626004276 glycerol kinase; Provisional; Region: glpK; PRK00047 931626004277 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 931626004278 N- and C-terminal domain interface [polypeptide binding]; other site 931626004279 active site 931626004280 MgATP binding site [chemical binding]; other site 931626004281 catalytic site [active] 931626004282 metal binding site [ion binding]; metal-binding site 931626004283 glycerol binding site [chemical binding]; other site 931626004284 homotetramer interface [polypeptide binding]; other site 931626004285 homodimer interface [polypeptide binding]; other site 931626004286 FBP binding site [chemical binding]; other site 931626004287 protein IIAGlc interface [polypeptide binding]; other site 931626004288 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 931626004289 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 931626004290 active site 931626004291 PHP Thumb interface [polypeptide binding]; other site 931626004292 metal binding site [ion binding]; metal-binding site 931626004293 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 931626004294 generic binding surface I; other site 931626004295 generic binding surface II; other site 931626004296 6-phosphofructokinase; Provisional; Region: PRK03202 931626004297 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 931626004298 active site 931626004299 ADP/pyrophosphate binding site [chemical binding]; other site 931626004300 dimerization interface [polypeptide binding]; other site 931626004301 allosteric effector site; other site 931626004302 fructose-1,6-bisphosphate binding site; other site 931626004303 pyruvate kinase; Provisional; Region: PRK06354 931626004304 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 931626004305 domain interfaces; other site 931626004306 active site 931626004307 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 931626004308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626004309 dimerization interface [polypeptide binding]; other site 931626004310 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 931626004311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626004312 dimer interface [polypeptide binding]; other site 931626004313 phosphorylation site [posttranslational modification] 931626004314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626004315 ATP binding site [chemical binding]; other site 931626004316 Mg2+ binding site [ion binding]; other site 931626004317 G-X-G motif; other site 931626004318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626004319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626004320 active site 931626004321 phosphorylation site [posttranslational modification] 931626004322 intermolecular recognition site; other site 931626004323 dimerization interface [polypeptide binding]; other site 931626004324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626004325 DNA binding site [nucleotide binding] 931626004326 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 931626004327 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 931626004328 Ligand Binding Site [chemical binding]; other site 931626004329 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 931626004330 proline aminopeptidase P II; Provisional; Region: PRK10879 931626004331 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 931626004332 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 931626004333 active site 931626004334 S-adenosylmethionine synthetase; Validated; Region: PRK05250 931626004335 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 931626004336 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 931626004337 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 931626004338 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 931626004339 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 931626004340 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 931626004341 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 931626004342 homodimer interface [polypeptide binding]; other site 931626004343 active site 931626004344 TDP-binding site; other site 931626004345 acceptor substrate-binding pocket; other site 931626004346 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 931626004347 Peptidase family U32; Region: Peptidase_U32; pfam01136 931626004348 Collagenase; Region: DUF3656; pfam12392 931626004349 Peptidase family U32; Region: Peptidase_U32; cl03113 931626004350 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 931626004351 MutS domain III; Region: MutS_III; pfam05192 931626004352 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 931626004353 Walker A/P-loop; other site 931626004354 ATP binding site [chemical binding]; other site 931626004355 Q-loop/lid; other site 931626004356 ABC transporter signature motif; other site 931626004357 Walker B; other site 931626004358 D-loop; other site 931626004359 H-loop/switch region; other site 931626004360 Smr domain; Region: Smr; pfam01713 931626004361 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 931626004362 trimer interface [polypeptide binding]; other site 931626004363 active site 931626004364 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 931626004365 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 931626004366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626004367 catalytic residue [active] 931626004368 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 931626004369 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 931626004370 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 931626004371 Ligand Binding Site [chemical binding]; other site 931626004372 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 931626004373 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 931626004374 HflX GTPase family; Region: HflX; cd01878 931626004375 G1 box; other site 931626004376 GTP/Mg2+ binding site [chemical binding]; other site 931626004377 Switch I region; other site 931626004378 G2 box; other site 931626004379 G3 box; other site 931626004380 Switch II region; other site 931626004381 G4 box; other site 931626004382 G5 box; other site 931626004383 Uncharacterized conserved protein [Function unknown]; Region: COG1739 931626004384 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 931626004385 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 931626004386 VanZ like family; Region: VanZ; pfam04892 931626004387 DNA repair protein RadA; Provisional; Region: PRK11823 931626004388 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 931626004389 Walker A motif/ATP binding site; other site 931626004390 ATP binding site [chemical binding]; other site 931626004391 Walker B motif; other site 931626004392 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 931626004393 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 931626004394 RuvA N terminal domain; Region: RuvA_N; pfam01330 931626004395 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 931626004396 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 931626004397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626004398 Walker A motif; other site 931626004399 ATP binding site [chemical binding]; other site 931626004400 Walker B motif; other site 931626004401 arginine finger; other site 931626004402 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 931626004403 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 931626004404 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 931626004405 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 931626004406 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 931626004407 Preprotein translocase subunit; Region: YajC; pfam02699 931626004408 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 931626004409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626004410 FeS/SAM binding site; other site 931626004411 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 931626004412 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 931626004413 RNA binding site [nucleotide binding]; other site 931626004414 Transcription termination factor [Transcription]; Region: Rho; COG1158 931626004415 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 931626004416 RNA binding site [nucleotide binding]; other site 931626004417 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 931626004418 Walker A motif; other site 931626004419 ATP binding site [chemical binding]; other site 931626004420 Walker B motif; other site 931626004421 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 931626004422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626004423 S-adenosylmethionine binding site [chemical binding]; other site 931626004424 elongation factor P; Validated; Region: PRK00529 931626004425 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 931626004426 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 931626004427 RNA binding site [nucleotide binding]; other site 931626004428 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 931626004429 RNA binding site [nucleotide binding]; other site 931626004430 Asp23 family; Region: Asp23; pfam03780 931626004431 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 931626004432 putative RNA binding site [nucleotide binding]; other site 931626004433 Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533 931626004434 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 931626004435 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 931626004436 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 931626004437 generic binding surface I; other site 931626004438 generic binding surface II; other site 931626004439 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 931626004440 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 931626004441 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 931626004442 substrate binding pocket [chemical binding]; other site 931626004443 chain length determination region; other site 931626004444 substrate-Mg2+ binding site; other site 931626004445 catalytic residues [active] 931626004446 aspartate-rich region 1; other site 931626004447 active site lid residues [active] 931626004448 aspartate-rich region 2; other site 931626004449 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 931626004450 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931626004451 RNA binding surface [nucleotide binding]; other site 931626004452 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 931626004453 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 931626004454 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 931626004455 arginine repressor; Provisional; Region: argR; PRK00441 931626004456 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 931626004457 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 931626004458 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 931626004459 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 931626004460 Walker A/P-loop; other site 931626004461 ATP binding site [chemical binding]; other site 931626004462 Q-loop/lid; other site 931626004463 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 931626004464 ABC transporter signature motif; other site 931626004465 Walker B; other site 931626004466 D-loop; other site 931626004467 H-loop/switch region; other site 931626004468 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 931626004469 Propanediol utilisation protein PduL; Region: PduL; pfam06130 931626004470 Propanediol utilisation protein PduL; Region: PduL; pfam06130 931626004471 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 931626004472 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 931626004473 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 931626004474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626004475 Walker A motif; other site 931626004476 ATP binding site [chemical binding]; other site 931626004477 Walker B motif; other site 931626004478 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 931626004479 Chain length determinant protein; Region: Wzz; cl15801 931626004480 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 931626004481 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 931626004482 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626004483 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 931626004484 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 931626004485 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 931626004486 Bacterial sugar transferase; Region: Bac_transf; pfam02397 931626004487 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 931626004488 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931626004489 active site 931626004490 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 931626004491 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 931626004492 classical (c) SDRs; Region: SDR_c; cd05233 931626004493 NAD(P) binding site [chemical binding]; other site 931626004494 active site 931626004495 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 931626004496 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 931626004497 dimer interface [polypeptide binding]; other site 931626004498 tetramer interface [polypeptide binding]; other site 931626004499 PYR/PP interface [polypeptide binding]; other site 931626004500 TPP binding site [chemical binding]; other site 931626004501 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 931626004502 TPP-binding site [chemical binding]; other site 931626004503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931626004504 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 931626004505 putative ADP-binding pocket [chemical binding]; other site 931626004506 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931626004507 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 931626004508 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 931626004509 active site 931626004510 homodimer interface [polypeptide binding]; other site 931626004511 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 931626004512 putative ligand binding site [chemical binding]; other site 931626004513 putative catalytic site [active] 931626004514 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 931626004515 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 931626004516 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 931626004517 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931626004518 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931626004519 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 931626004520 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 931626004521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 931626004522 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 931626004523 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 931626004524 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626004525 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626004526 metal binding site [ion binding]; metal-binding site 931626004527 active site 931626004528 I-site; other site 931626004529 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 931626004530 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 931626004531 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 931626004532 active site 931626004533 catalytic residues [active] 931626004534 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 931626004535 putative active site [active] 931626004536 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 931626004537 EamA-like transporter family; Region: EamA; pfam00892 931626004538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626004539 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 931626004540 putative substrate translocation pore; other site 931626004541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626004542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626004543 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 931626004544 GIY-YIG motif/motif A; other site 931626004545 argininosuccinate lyase; Provisional; Region: PRK00855 931626004546 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 931626004547 active sites [active] 931626004548 tetramer interface [polypeptide binding]; other site 931626004549 argininosuccinate synthase; Provisional; Region: PRK13820 931626004550 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 931626004551 ANP binding site [chemical binding]; other site 931626004552 Substrate Binding Site II [chemical binding]; other site 931626004553 Substrate Binding Site I [chemical binding]; other site 931626004554 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 931626004555 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 931626004556 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 931626004557 heterotetramer interface [polypeptide binding]; other site 931626004558 active site pocket [active] 931626004559 cleavage site 931626004560 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 931626004561 feedback inhibition sensing region; other site 931626004562 homohexameric interface [polypeptide binding]; other site 931626004563 nucleotide binding site [chemical binding]; other site 931626004564 N-acetyl-L-glutamate binding site [chemical binding]; other site 931626004565 acetylornithine aminotransferase; Provisional; Region: PRK02627 931626004566 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 931626004567 inhibitor-cofactor binding pocket; inhibition site 931626004568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626004569 catalytic residue [active] 931626004570 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626004571 dimerization interface [polypeptide binding]; other site 931626004572 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626004573 dimer interface [polypeptide binding]; other site 931626004574 phosphorylation site [posttranslational modification] 931626004575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626004576 ATP binding site [chemical binding]; other site 931626004577 Mg2+ binding site [ion binding]; other site 931626004578 G-X-G motif; other site 931626004579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626004580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626004581 active site 931626004582 phosphorylation site [posttranslational modification] 931626004583 intermolecular recognition site; other site 931626004584 dimerization interface [polypeptide binding]; other site 931626004585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626004586 DNA binding site [nucleotide binding] 931626004587 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626004588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626004589 active site 931626004590 phosphorylation site [posttranslational modification] 931626004591 intermolecular recognition site; other site 931626004592 dimerization interface [polypeptide binding]; other site 931626004593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626004594 DNA binding site [nucleotide binding] 931626004595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626004596 dimer interface [polypeptide binding]; other site 931626004597 phosphorylation site [posttranslational modification] 931626004598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626004599 ATP binding site [chemical binding]; other site 931626004600 Mg2+ binding site [ion binding]; other site 931626004601 G-X-G motif; other site 931626004602 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 931626004603 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 931626004604 fumarate hydratase; Provisional; Region: PRK06246 931626004605 Fumarase C-terminus; Region: Fumerase_C; cl00795 931626004606 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931626004607 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626004608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626004609 homodimer interface [polypeptide binding]; other site 931626004610 catalytic residue [active] 931626004611 Transcriptional regulators [Transcription]; Region: PurR; COG1609 931626004612 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 931626004613 DNA binding site [nucleotide binding] 931626004614 domain linker motif; other site 931626004615 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 931626004616 ligand binding site [chemical binding]; other site 931626004617 dimerization interface [polypeptide binding]; other site 931626004618 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 931626004619 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 931626004620 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 931626004621 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 931626004622 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626004623 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626004624 substrate binding pocket [chemical binding]; other site 931626004625 membrane-bound complex binding site; other site 931626004626 hinge residues; other site 931626004627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626004628 dimer interface [polypeptide binding]; other site 931626004629 conserved gate region; other site 931626004630 putative PBP binding loops; other site 931626004631 ABC-ATPase subunit interface; other site 931626004632 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931626004633 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931626004634 Walker A/P-loop; other site 931626004635 ATP binding site [chemical binding]; other site 931626004636 Q-loop/lid; other site 931626004637 ABC transporter signature motif; other site 931626004638 Walker B; other site 931626004639 D-loop; other site 931626004640 H-loop/switch region; other site 931626004641 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 931626004642 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 931626004643 active site 931626004644 dimer interface [polypeptide binding]; other site 931626004645 SLBB domain; Region: SLBB; pfam10531 931626004646 comEA protein; Region: comE; TIGR01259 931626004647 Helix-hairpin-helix motif; Region: HHH; pfam00633 931626004648 HTH domain; Region: HTH_11; pfam08279 931626004649 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 931626004650 FOG: CBS domain [General function prediction only]; Region: COG0517 931626004651 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 931626004652 pyruvate phosphate dikinase; Provisional; Region: PRK09279 931626004653 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 931626004654 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 931626004655 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 931626004656 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 931626004657 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 931626004658 NAD binding site [chemical binding]; other site 931626004659 homodimer interface [polypeptide binding]; other site 931626004660 active site 931626004661 substrate binding site [chemical binding]; other site 931626004662 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 931626004663 active site residue [active] 931626004664 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 931626004665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626004666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626004667 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 931626004668 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 931626004669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626004670 Walker A/P-loop; other site 931626004671 ATP binding site [chemical binding]; other site 931626004672 Q-loop/lid; other site 931626004673 ABC transporter signature motif; other site 931626004674 Walker B; other site 931626004675 D-loop; other site 931626004676 H-loop/switch region; other site 931626004677 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 931626004678 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 931626004679 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 931626004680 Uncharacterized conserved protein [Function unknown]; Region: COG2966 931626004681 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 931626004682 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 931626004683 Flavoprotein; Region: Flavoprotein; pfam02441 931626004684 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 931626004685 Predicted membrane protein [Function unknown]; Region: COG4684 931626004686 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 931626004687 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 931626004688 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 931626004689 Carbon starvation protein CstA; Region: CstA; pfam02554 931626004690 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 931626004691 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 931626004692 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 931626004693 active site 931626004694 metal binding site [ion binding]; metal-binding site 931626004695 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 931626004696 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 931626004697 nucleoside/Zn binding site; other site 931626004698 dimer interface [polypeptide binding]; other site 931626004699 catalytic motif [active] 931626004700 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 931626004701 Uncharacterized conserved protein [Function unknown]; Region: COG2006 931626004702 ketol-acid reductoisomerase; Provisional; Region: PRK05479 931626004703 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 931626004704 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 931626004705 2-isopropylmalate synthase; Validated; Region: PRK00915 931626004706 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 931626004707 active site 931626004708 catalytic residues [active] 931626004709 metal binding site [ion binding]; metal-binding site 931626004710 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 931626004711 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 931626004712 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 931626004713 active site 931626004714 catalytic residues [active] 931626004715 metal binding site [ion binding]; metal-binding site 931626004716 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 931626004717 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 931626004718 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 931626004719 substrate binding site [chemical binding]; other site 931626004720 ligand binding site [chemical binding]; other site 931626004721 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 931626004722 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 931626004723 substrate binding site [chemical binding]; other site 931626004724 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 931626004725 tartrate dehydrogenase; Region: TTC; TIGR02089 931626004726 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 931626004727 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 931626004728 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 931626004729 PYR/PP interface [polypeptide binding]; other site 931626004730 dimer interface [polypeptide binding]; other site 931626004731 TPP binding site [chemical binding]; other site 931626004732 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 931626004733 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 931626004734 TPP-binding site [chemical binding]; other site 931626004735 dimer interface [polypeptide binding]; other site 931626004736 PAS fold; Region: PAS_4; pfam08448 931626004737 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626004738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626004739 metal binding site [ion binding]; metal-binding site 931626004740 active site 931626004741 I-site; other site 931626004742 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626004743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626004744 metal binding site [ion binding]; metal-binding site 931626004745 active site 931626004746 I-site; other site 931626004747 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 931626004748 Cl- selectivity filter; other site 931626004749 Cl- binding residues [ion binding]; other site 931626004750 pore gating glutamate residue; other site 931626004751 dimer interface [polypeptide binding]; other site 931626004752 CBD_II domain; Region: CBD_II; smart00637 931626004753 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626004754 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626004755 Zn2+ binding site [ion binding]; other site 931626004756 Mg2+ binding site [ion binding]; other site 931626004757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626004758 non-specific DNA binding site [nucleotide binding]; other site 931626004759 salt bridge; other site 931626004760 sequence-specific DNA binding site [nucleotide binding]; other site 931626004761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626004762 dimerization interface [polypeptide binding]; other site 931626004763 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931626004764 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626004765 dimer interface [polypeptide binding]; other site 931626004766 putative CheW interface [polypeptide binding]; other site 931626004767 PAS fold; Region: PAS_4; pfam08448 931626004768 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626004769 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626004770 metal binding site [ion binding]; metal-binding site 931626004771 active site 931626004772 I-site; other site 931626004773 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626004774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626004775 metal binding site [ion binding]; metal-binding site 931626004776 active site 931626004777 I-site; other site 931626004778 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626004779 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 931626004780 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 931626004781 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626004782 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626004783 metal binding site [ion binding]; metal-binding site 931626004784 active site 931626004785 I-site; other site 931626004786 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626004787 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 931626004788 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 931626004789 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 931626004790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626004791 dimer interface [polypeptide binding]; other site 931626004792 conserved gate region; other site 931626004793 putative PBP binding loops; other site 931626004794 ABC-ATPase subunit interface; other site 931626004795 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 931626004796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626004797 dimer interface [polypeptide binding]; other site 931626004798 conserved gate region; other site 931626004799 putative PBP binding loops; other site 931626004800 ABC-ATPase subunit interface; other site 931626004801 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 931626004802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626004803 Walker A/P-loop; other site 931626004804 ATP binding site [chemical binding]; other site 931626004805 Q-loop/lid; other site 931626004806 ABC transporter signature motif; other site 931626004807 Walker B; other site 931626004808 D-loop; other site 931626004809 H-loop/switch region; other site 931626004810 TOBE domain; Region: TOBE_2; pfam08402 931626004811 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626004812 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626004813 Zn2+ binding site [ion binding]; other site 931626004814 Mg2+ binding site [ion binding]; other site 931626004815 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 931626004816 dimer interface [polypeptide binding]; other site 931626004817 [2Fe-2S] cluster binding site [ion binding]; other site 931626004818 4Fe-4S binding domain; Region: Fer4_6; pfam12837 931626004819 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 931626004820 4Fe-4S binding domain; Region: Fer4; pfam00037 931626004821 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 931626004822 Putative Fe-S cluster; Region: FeS; cl17515 931626004823 PAS domain; Region: PAS; smart00091 931626004824 PAS domain; Region: PAS_9; pfam13426 931626004825 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 931626004826 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931626004827 active site 931626004828 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 931626004829 GSH binding site [chemical binding]; other site 931626004830 catalytic residues [active] 931626004831 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 931626004832 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 931626004833 MPT binding site; other site 931626004834 trimer interface [polypeptide binding]; other site 931626004835 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 931626004836 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 931626004837 ATP binding site [chemical binding]; other site 931626004838 substrate interface [chemical binding]; other site 931626004839 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 931626004840 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626004841 FeS/SAM binding site; other site 931626004842 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 931626004843 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 931626004844 trimer interface [polypeptide binding]; other site 931626004845 dimer interface [polypeptide binding]; other site 931626004846 putative active site [active] 931626004847 MOSC domain; Region: MOSC; pfam03473 931626004848 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 931626004849 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 931626004850 dimer interface [polypeptide binding]; other site 931626004851 active site 931626004852 glycine-pyridoxal phosphate binding site [chemical binding]; other site 931626004853 folate binding site [chemical binding]; other site 931626004854 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 931626004855 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931626004856 DNA binding site [nucleotide binding] 931626004857 active site 931626004858 Int/Topo IB signature motif; other site 931626004859 Homeodomain-like domain; Region: HTH_32; pfam13565 931626004860 putative transposase OrfB; Reviewed; Region: PHA02517 931626004861 Integrase core domain; Region: rve; pfam00665 931626004862 Integrase core domain; Region: rve_3; pfam13683 931626004863 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 931626004864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626004865 Walker A motif; other site 931626004866 ATP binding site [chemical binding]; other site 931626004867 Walker B motif; other site 931626004868 arginine finger; other site 931626004869 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931626004870 Domain of unknown function (DUF955); Region: DUF955; pfam06114 931626004871 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 931626004872 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 931626004873 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626004874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626004875 non-specific DNA binding site [nucleotide binding]; other site 931626004876 salt bridge; other site 931626004877 sequence-specific DNA binding site [nucleotide binding]; other site 931626004878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626004879 non-specific DNA binding site [nucleotide binding]; other site 931626004880 salt bridge; other site 931626004881 sequence-specific DNA binding site [nucleotide binding]; other site 931626004882 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 931626004883 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 931626004884 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 931626004885 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 931626004886 active site 931626004887 Zn binding site [ion binding]; other site 931626004888 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 931626004889 trimer interface [polypeptide binding]; other site 931626004890 active site 931626004891 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 931626004892 trimer interface [polypeptide binding]; other site 931626004893 active site 931626004894 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 931626004895 Penicillinase repressor; Region: Pencillinase_R; cl17580 931626004896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626004897 S-adenosylmethionine binding site [chemical binding]; other site 931626004898 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 931626004899 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 931626004900 recombination factor protein RarA; Reviewed; Region: PRK13342 931626004901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626004902 Walker A motif; other site 931626004903 ATP binding site [chemical binding]; other site 931626004904 Walker B motif; other site 931626004905 arginine finger; other site 931626004906 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 931626004907 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 931626004908 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 931626004909 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 931626004910 Peptidase M16C associated; Region: M16C_assoc; pfam08367 931626004911 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 931626004912 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 931626004913 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 931626004914 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 931626004915 cobalt transport protein CbiM; Validated; Region: PRK06265 931626004916 PDGLE domain; Region: PDGLE; pfam13190 931626004917 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 931626004918 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 931626004919 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931626004920 Walker A/P-loop; other site 931626004921 ATP binding site [chemical binding]; other site 931626004922 Q-loop/lid; other site 931626004923 ABC transporter signature motif; other site 931626004924 Walker B; other site 931626004925 D-loop; other site 931626004926 H-loop/switch region; other site 931626004927 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 931626004928 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931626004929 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 931626004930 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 931626004931 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 931626004932 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931626004933 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 931626004934 Domain of unknown function DUF21; Region: DUF21; pfam01595 931626004935 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 931626004936 Transporter associated domain; Region: CorC_HlyC; smart01091 931626004937 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626004938 B12 binding site [chemical binding]; other site 931626004939 Radical SAM superfamily; Region: Radical_SAM; pfam04055 931626004940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626004941 FeS/SAM binding site; other site 931626004942 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626004943 B12 binding site [chemical binding]; other site 931626004944 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 931626004945 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626004946 FeS/SAM binding site; other site 931626004947 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931626004948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626004949 S-adenosylmethionine binding site [chemical binding]; other site 931626004950 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 931626004951 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 931626004952 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 931626004953 putative dimer interface [polypeptide binding]; other site 931626004954 active site pocket [active] 931626004955 putative cataytic base [active] 931626004956 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 931626004957 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 931626004958 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 931626004959 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 931626004960 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase [Posttranslational modification, protein turnover, chaperones / Transcription]; Region: HypB; COG0378 931626004961 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626004962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626004963 Walker A/P-loop; other site 931626004964 ATP binding site [chemical binding]; other site 931626004965 Q-loop/lid; other site 931626004966 ABC transporter signature motif; other site 931626004967 Walker B; other site 931626004968 D-loop; other site 931626004969 H-loop/switch region; other site 931626004970 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 931626004971 Domain of unknown function (DUF364); Region: DUF364; pfam04016 931626004972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931626004973 NTPase; Region: NTPase_1; cl17478 931626004974 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 931626004975 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 931626004976 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 931626004977 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626004978 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626004979 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 931626004980 Walker A/P-loop; other site 931626004981 ATP binding site [chemical binding]; other site 931626004982 Q-loop/lid; other site 931626004983 ABC transporter signature motif; other site 931626004984 Walker B; other site 931626004985 D-loop; other site 931626004986 H-loop/switch region; other site 931626004987 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 931626004988 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 931626004989 Ligand Binding Site [chemical binding]; other site 931626004990 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 931626004991 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 931626004992 active site 931626004993 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cl00018 931626004994 non-heme iron binding site [ion binding]; other site 931626004995 Desulfoferrodoxin [Energy production and conversion]; Region: COG2033 931626004996 dimer interface [polypeptide binding]; other site 931626004997 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 931626004998 non-heme iron binding site [ion binding]; other site 931626004999 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 931626005000 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 931626005001 nudix motif; other site 931626005002 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 931626005003 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 931626005004 catalytic triad [active] 931626005005 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 931626005006 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931626005007 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931626005008 Predicted transcriptional regulator [Transcription]; Region: COG2378 931626005009 HTH domain; Region: HTH_11; pfam08279 931626005010 WYL domain; Region: WYL; pfam13280 931626005011 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 931626005012 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 931626005013 conserved cys residue [active] 931626005014 HflK protein; Region: hflK; TIGR01933 931626005015 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 931626005016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626005017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626005018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 931626005019 dimerization interface [polypeptide binding]; other site 931626005020 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 931626005021 intersubunit interface [polypeptide binding]; other site 931626005022 active site 931626005023 catalytic residue [active] 931626005024 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 931626005025 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931626005026 nucleotide binding site [chemical binding]; other site 931626005027 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931626005028 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 931626005029 putative active site [active] 931626005030 metal binding site [ion binding]; metal-binding site 931626005031 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 931626005032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626005033 active site 931626005034 motif I; other site 931626005035 motif II; other site 931626005036 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 931626005037 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 931626005038 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 931626005039 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 931626005040 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 931626005041 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 931626005042 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 931626005043 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 931626005044 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626005045 FeS/SAM binding site; other site 931626005046 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626005047 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 931626005048 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 931626005049 Cupin domain; Region: Cupin_2; pfam07883 931626005050 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626005051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626005052 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 931626005053 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931626005054 catalytic loop [active] 931626005055 iron binding site [ion binding]; other site 931626005056 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 931626005057 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 931626005058 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 931626005059 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626005060 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 931626005061 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 931626005062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626005063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626005064 myosin-cross-reactive antigen; Provisional; Region: PRK13977 931626005065 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626005066 Y-family of DNA polymerases; Region: PolY; cl12025 931626005067 active site 931626005068 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 931626005069 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 931626005070 putative active site [active] 931626005071 putative NTP binding site [chemical binding]; other site 931626005072 putative nucleic acid binding site [nucleotide binding]; other site 931626005073 Type II intron maturase; Region: Intron_maturas2; pfam01348 931626005074 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 931626005075 DNA binding site [nucleotide binding] 931626005076 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 931626005077 TfoX N-terminal domain; Region: TfoX_N; pfam04993 931626005078 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 931626005079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 931626005080 DEAD_2; Region: DEAD_2; pfam06733 931626005081 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 931626005082 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 931626005083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931626005084 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931626005085 Nucleoside diphosphate kinase; Region: NDK; pfam00334 931626005086 active site 931626005087 multimer interface [polypeptide binding]; other site 931626005088 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 931626005089 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 931626005090 active site 931626005091 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 931626005092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626005093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626005094 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 931626005095 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 931626005096 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 931626005097 putative binding surface; other site 931626005098 active site 931626005099 P2 response regulator binding domain; Region: P2; pfam07194 931626005100 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 931626005101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626005102 ATP binding site [chemical binding]; other site 931626005103 Mg2+ binding site [ion binding]; other site 931626005104 G-X-G motif; other site 931626005105 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 931626005106 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 931626005107 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931626005108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626005109 dimerization interface [polypeptide binding]; other site 931626005110 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626005111 dimer interface [polypeptide binding]; other site 931626005112 putative CheW interface [polypeptide binding]; other site 931626005113 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 931626005114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626005115 active site 931626005116 phosphorylation site [posttranslational modification] 931626005117 intermolecular recognition site; other site 931626005118 CheB methylesterase; Region: CheB_methylest; pfam01339 931626005119 CheD chemotactic sensory transduction; Region: CheD; cl00810 931626005120 PAS domain; Region: PAS; smart00091 931626005121 PAS domain; Region: PAS_9; pfam13426 931626005122 PAS domain S-box; Region: sensory_box; TIGR00229 931626005123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005124 putative active site [active] 931626005125 heme pocket [chemical binding]; other site 931626005126 PAS domain S-box; Region: sensory_box; TIGR00229 931626005127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005128 putative active site [active] 931626005129 heme pocket [chemical binding]; other site 931626005130 PAS domain S-box; Region: sensory_box; TIGR00229 931626005131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626005132 dimer interface [polypeptide binding]; other site 931626005133 phosphorylation site [posttranslational modification] 931626005134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626005135 ATP binding site [chemical binding]; other site 931626005136 Mg2+ binding site [ion binding]; other site 931626005137 G-X-G motif; other site 931626005138 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931626005139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626005140 active site 931626005141 phosphorylation site [posttranslational modification] 931626005142 intermolecular recognition site; other site 931626005143 dimerization interface [polypeptide binding]; other site 931626005144 Response regulator receiver domain; Region: Response_reg; pfam00072 931626005145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626005146 active site 931626005147 phosphorylation site [posttranslational modification] 931626005148 intermolecular recognition site; other site 931626005149 dimerization interface [polypeptide binding]; other site 931626005150 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 931626005151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005152 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 931626005153 putative active site [active] 931626005154 heme pocket [chemical binding]; other site 931626005155 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005156 putative active site [active] 931626005157 heme pocket [chemical binding]; other site 931626005158 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626005159 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626005160 metal binding site [ion binding]; metal-binding site 931626005161 active site 931626005162 I-site; other site 931626005163 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626005164 Zn2+ binding site [ion binding]; other site 931626005165 Mg2+ binding site [ion binding]; other site 931626005166 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 931626005167 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931626005168 ligand binding site [chemical binding]; other site 931626005169 flexible hinge region; other site 931626005170 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 931626005171 non-specific DNA interactions [nucleotide binding]; other site 931626005172 DNA binding site [nucleotide binding] 931626005173 sequence specific DNA binding site [nucleotide binding]; other site 931626005174 putative cAMP binding site [chemical binding]; other site 931626005175 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626005176 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 931626005177 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 931626005178 MFS/sugar transport protein; Region: MFS_2; pfam13347 931626005179 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626005180 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626005181 B12 binding site [chemical binding]; other site 931626005182 cobalt ligand [ion binding]; other site 931626005183 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 931626005184 MFS/sugar transport protein; Region: MFS_2; pfam13347 931626005185 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 931626005186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626005187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626005188 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 931626005189 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 931626005190 SNF2 Helicase protein; Region: DUF3670; pfam12419 931626005191 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 931626005192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931626005193 ATP binding site [chemical binding]; other site 931626005194 putative Mg++ binding site [ion binding]; other site 931626005195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931626005196 nucleotide binding region [chemical binding]; other site 931626005197 ATP-binding site [chemical binding]; other site 931626005198 phosphodiesterase YaeI; Provisional; Region: PRK11340 931626005199 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 931626005200 putative active site [active] 931626005201 putative metal binding site [ion binding]; other site 931626005202 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626005203 MarR family; Region: MarR; pfam01047 931626005204 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 931626005205 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 931626005206 P loop; other site 931626005207 Nucleotide binding site [chemical binding]; other site 931626005208 DTAP/Switch II; other site 931626005209 Switch I; other site 931626005210 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 931626005211 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 931626005212 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 931626005213 P loop; other site 931626005214 Nucleotide binding site [chemical binding]; other site 931626005215 DTAP/Switch II; other site 931626005216 Switch I; other site 931626005217 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 931626005218 active site 931626005219 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626005220 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626005221 Clostridial hydrophobic W; Region: ChW; pfam07538 931626005222 Clostridial hydrophobic W; Region: ChW; pfam07538 931626005223 Clostridial hydrophobic W; Region: ChW; pfam07538 931626005224 butyrate kinase; Provisional; Region: PRK03011 931626005225 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 931626005226 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 931626005227 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626005228 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626005229 dimer interface [polypeptide binding]; other site 931626005230 putative CheW interface [polypeptide binding]; other site 931626005231 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 931626005232 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626005233 substrate binding pocket [chemical binding]; other site 931626005234 membrane-bound complex binding site; other site 931626005235 hinge residues; other site 931626005236 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 931626005237 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 931626005238 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931626005239 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 931626005240 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 931626005241 TIGR03987 family protein; Region: TIGR03987 931626005242 RNA polymerase sigma factor; Provisional; Region: PRK11924 931626005243 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931626005244 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931626005245 DNA binding residues [nucleotide binding] 931626005246 L-asparagine permease; Provisional; Region: PRK15049 931626005247 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 931626005248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931626005249 putative DNA binding site [nucleotide binding]; other site 931626005250 putative Zn2+ binding site [ion binding]; other site 931626005251 AsnC family; Region: AsnC_trans_reg; pfam01037 931626005252 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931626005253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626005254 dimerization interface [polypeptide binding]; other site 931626005255 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626005256 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626005257 dimer interface [polypeptide binding]; other site 931626005258 putative CheW interface [polypeptide binding]; other site 931626005259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626005260 dimerization interface [polypeptide binding]; other site 931626005261 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626005262 dimer interface [polypeptide binding]; other site 931626005263 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931626005264 putative CheW interface [polypeptide binding]; other site 931626005265 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 931626005266 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 931626005267 ligand binding site [chemical binding]; other site 931626005268 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 931626005269 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626005270 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626005271 metal binding site [ion binding]; metal-binding site 931626005272 active site 931626005273 I-site; other site 931626005274 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626005275 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 931626005276 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 931626005277 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 931626005278 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931626005279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626005280 dimerization interface [polypeptide binding]; other site 931626005281 PAS fold; Region: PAS_4; pfam08448 931626005282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626005283 dimer interface [polypeptide binding]; other site 931626005284 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931626005285 putative CheW interface [polypeptide binding]; other site 931626005286 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 931626005287 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 931626005288 PAS domain S-box; Region: sensory_box; TIGR00229 931626005289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005290 putative active site [active] 931626005291 heme pocket [chemical binding]; other site 931626005292 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626005293 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626005294 metal binding site [ion binding]; metal-binding site 931626005295 active site 931626005296 I-site; other site 931626005297 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626005298 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 931626005299 Dynamin family; Region: Dynamin_N; pfam00350 931626005300 G1 box; other site 931626005301 GTP/Mg2+ binding site [chemical binding]; other site 931626005302 G2 box; other site 931626005303 Switch I region; other site 931626005304 G3 box; other site 931626005305 Switch II region; other site 931626005306 G4 box; other site 931626005307 G5 box; other site 931626005308 Cache domain; Region: Cache_1; pfam02743 931626005309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626005310 dimerization interface [polypeptide binding]; other site 931626005311 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626005312 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626005313 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626005314 dimer interface [polypeptide binding]; other site 931626005315 putative CheW interface [polypeptide binding]; other site 931626005316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626005317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626005318 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 931626005319 putative dimerization interface [polypeptide binding]; other site 931626005320 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 931626005321 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 931626005322 4Fe-4S binding domain; Region: Fer4; pfam00037 931626005323 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 931626005324 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 931626005325 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 931626005326 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626005327 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626005328 B12 binding site [chemical binding]; other site 931626005329 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 931626005330 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 931626005331 substrate binding pocket [chemical binding]; other site 931626005332 dimer interface [polypeptide binding]; other site 931626005333 inhibitor binding site; inhibition site 931626005334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626005335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626005336 FtsH Extracellular; Region: FtsH_ext; pfam06480 931626005337 Bacterial Ig-like domain; Region: Big_5; pfam13205 931626005338 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 931626005339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626005340 Walker A motif; other site 931626005341 ATP binding site [chemical binding]; other site 931626005342 Walker B motif; other site 931626005343 arginine finger; other site 931626005344 Peptidase family M41; Region: Peptidase_M41; pfam01434 931626005345 Predicted transcriptional regulators [Transcription]; Region: COG1695 931626005346 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 931626005347 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 931626005348 Coenzyme A transferase; Region: CoA_trans; smart00882 931626005349 Coenzyme A transferase; Region: CoA_trans; cl17247 931626005350 AMP-binding domain protein; Validated; Region: PRK08315 931626005351 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931626005352 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 931626005353 acyl-activating enzyme (AAE) consensus motif; other site 931626005354 acyl-activating enzyme (AAE) consensus motif; other site 931626005355 putative AMP binding site [chemical binding]; other site 931626005356 putative active site [active] 931626005357 putative CoA binding site [chemical binding]; other site 931626005358 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 931626005359 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 931626005360 active site 931626005361 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 931626005362 Ligand binding site [chemical binding]; other site 931626005363 Electron transfer flavoprotein domain; Region: ETF; pfam01012 931626005364 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626005365 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626005366 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 931626005367 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 931626005368 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 931626005369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626005370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626005371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626005372 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931626005373 putative substrate translocation pore; other site 931626005374 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626005375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626005376 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626005377 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626005378 B12 binding site [chemical binding]; other site 931626005379 cobalt ligand [ion binding]; other site 931626005380 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 931626005381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626005382 putative substrate translocation pore; other site 931626005383 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 931626005384 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 931626005385 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931626005386 DNA binding residues [nucleotide binding] 931626005387 dimer interface [polypeptide binding]; other site 931626005388 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 931626005389 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931626005390 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 931626005391 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931626005392 OsmC-like protein; Region: OsmC; pfam02566 931626005393 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626005394 MarR family; Region: MarR_2; pfam12802 931626005395 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 931626005396 active site 931626005397 catalytic triad [active] 931626005398 oxyanion hole [active] 931626005399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 931626005400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626005401 Coenzyme A binding pocket [chemical binding]; other site 931626005402 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 931626005403 PAS domain S-box; Region: sensory_box; TIGR00229 931626005404 Bacterial transcriptional activator domain; Region: BTAD; smart01043 931626005405 Cache domain; Region: Cache_1; pfam02743 931626005406 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931626005407 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626005408 dimerization interface [polypeptide binding]; other site 931626005409 PAS fold; Region: PAS_4; pfam08448 931626005410 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931626005411 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626005412 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626005413 dimer interface [polypeptide binding]; other site 931626005414 putative CheW interface [polypeptide binding]; other site 931626005415 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626005416 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 931626005417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931626005418 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931626005419 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626005420 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626005421 ABC transporter; Region: ABC_tran_2; pfam12848 931626005422 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626005423 thymidylate synthase; Provisional; Region: thyA; PRK00956 931626005424 Predicted transcriptional regulators [Transcription]; Region: COG1695 931626005425 Transcriptional regulator PadR-like family; Region: PadR; cl17335 931626005426 Predicted ATPase [General function prediction only]; Region: COG3910 931626005427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626005428 Walker A/P-loop; other site 931626005429 ATP binding site [chemical binding]; other site 931626005430 Q-loop/lid; other site 931626005431 ABC transporter signature motif; other site 931626005432 Walker B; other site 931626005433 D-loop; other site 931626005434 H-loop/switch region; other site 931626005435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626005436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626005437 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 931626005438 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 931626005439 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626005440 Walker A/P-loop; other site 931626005441 ATP binding site [chemical binding]; other site 931626005442 Q-loop/lid; other site 931626005443 ABC transporter signature motif; other site 931626005444 Walker B; other site 931626005445 D-loop; other site 931626005446 H-loop/switch region; other site 931626005447 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931626005448 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 931626005449 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931626005450 4Fe-4S binding domain; Region: Fer4_5; pfam12801 931626005451 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626005452 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626005453 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626005454 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 931626005455 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 931626005456 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 931626005457 putative ligand binding site [chemical binding]; other site 931626005458 putative NAD binding site [chemical binding]; other site 931626005459 catalytic site [active] 931626005460 PAS domain S-box; Region: sensory_box; TIGR00229 931626005461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005462 putative active site [active] 931626005463 heme pocket [chemical binding]; other site 931626005464 PAS domain S-box; Region: sensory_box; TIGR00229 931626005465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005466 putative active site [active] 931626005467 heme pocket [chemical binding]; other site 931626005468 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626005469 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626005470 metal binding site [ion binding]; metal-binding site 931626005471 active site 931626005472 I-site; other site 931626005473 Surface antigen [General function prediction only]; Region: COG3942 931626005474 CHAP domain; Region: CHAP; pfam05257 931626005475 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626005476 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 931626005477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626005478 S-adenosylmethionine binding site [chemical binding]; other site 931626005479 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626005480 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626005481 Walker A/P-loop; other site 931626005482 ATP binding site [chemical binding]; other site 931626005483 Q-loop/lid; other site 931626005484 ABC transporter signature motif; other site 931626005485 Walker B; other site 931626005486 D-loop; other site 931626005487 H-loop/switch region; other site 931626005488 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 931626005489 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 931626005490 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 931626005491 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 931626005492 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 931626005493 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 931626005494 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 931626005495 dihydroorotase; Validated; Region: pyrC; PRK09357 931626005496 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931626005497 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 931626005498 active site 931626005499 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 931626005500 active site 931626005501 dimer interface [polypeptide binding]; other site 931626005502 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 931626005503 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 931626005504 FAD binding pocket [chemical binding]; other site 931626005505 FAD binding motif [chemical binding]; other site 931626005506 phosphate binding motif [ion binding]; other site 931626005507 beta-alpha-beta structure motif; other site 931626005508 NAD binding pocket [chemical binding]; other site 931626005509 Iron coordination center [ion binding]; other site 931626005510 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 931626005511 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 931626005512 heterodimer interface [polypeptide binding]; other site 931626005513 active site 931626005514 FMN binding site [chemical binding]; other site 931626005515 homodimer interface [polypeptide binding]; other site 931626005516 substrate binding site [chemical binding]; other site 931626005517 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931626005518 active site 931626005519 intracellular protease, PfpI family; Region: PfpI; TIGR01382 931626005520 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 931626005521 proposed catalytic triad [active] 931626005522 conserved cys residue [active] 931626005523 transaminase; Validated; Region: PRK07324 931626005524 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626005525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626005526 homodimer interface [polypeptide binding]; other site 931626005527 catalytic residue [active] 931626005528 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 931626005529 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 931626005530 tetramer interface [polypeptide binding]; other site 931626005531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626005532 catalytic residue [active] 931626005533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626005534 Zn2+ binding site [ion binding]; other site 931626005535 Mg2+ binding site [ion binding]; other site 931626005536 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626005537 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626005538 Zn2+ binding site [ion binding]; other site 931626005539 Mg2+ binding site [ion binding]; other site 931626005540 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 931626005541 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 931626005542 active site 931626005543 nucleophile elbow; other site 931626005544 Uncharacterized conserved protein [Function unknown]; Region: COG3287 931626005545 FIST N domain; Region: FIST; pfam08495 931626005546 FIST C domain; Region: FIST_C; pfam10442 931626005547 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626005548 metal binding site [ion binding]; metal-binding site 931626005549 active site 931626005550 I-site; other site 931626005551 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626005552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626005553 metal binding site [ion binding]; metal-binding site 931626005554 active site 931626005555 I-site; other site 931626005556 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626005557 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626005558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005559 putative active site [active] 931626005560 heme pocket [chemical binding]; other site 931626005561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626005562 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 931626005563 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931626005564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626005565 active site 931626005566 phosphorylation site [posttranslational modification] 931626005567 intermolecular recognition site; other site 931626005568 dimerization interface [polypeptide binding]; other site 931626005569 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626005570 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626005571 metal binding site [ion binding]; metal-binding site 931626005572 active site 931626005573 I-site; other site 931626005574 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 931626005575 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931626005576 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 931626005577 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 931626005578 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 931626005579 dimerization interface [polypeptide binding]; other site 931626005580 ATP binding site [chemical binding]; other site 931626005581 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 931626005582 dimerization interface [polypeptide binding]; other site 931626005583 ATP binding site [chemical binding]; other site 931626005584 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 931626005585 putative active site [active] 931626005586 catalytic triad [active] 931626005587 AIR carboxylase; Region: AIRC; pfam00731 931626005588 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 931626005589 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 931626005590 ATP binding site [chemical binding]; other site 931626005591 active site 931626005592 substrate binding site [chemical binding]; other site 931626005593 amidophosphoribosyltransferase; Provisional; Region: PRK05793 931626005594 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 931626005595 active site 931626005596 tetramer interface [polypeptide binding]; other site 931626005597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931626005598 active site 931626005599 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 931626005600 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 931626005601 dimerization interface [polypeptide binding]; other site 931626005602 putative ATP binding site [chemical binding]; other site 931626005603 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 931626005604 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 931626005605 active site 931626005606 substrate binding site [chemical binding]; other site 931626005607 cosubstrate binding site; other site 931626005608 catalytic site [active] 931626005609 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 931626005610 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 931626005611 purine monophosphate binding site [chemical binding]; other site 931626005612 dimer interface [polypeptide binding]; other site 931626005613 putative catalytic residues [active] 931626005614 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 931626005615 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 931626005616 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 931626005617 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 931626005618 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 931626005619 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 931626005620 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 931626005621 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 931626005622 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 931626005623 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 931626005624 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 931626005625 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 931626005626 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 931626005627 Glycoprotease family; Region: Peptidase_M22; pfam00814 931626005628 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 931626005629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626005630 Coenzyme A binding pocket [chemical binding]; other site 931626005631 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 931626005632 UGMP family protein; Validated; Region: PRK09604 931626005633 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 931626005634 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 931626005635 oligomerisation interface [polypeptide binding]; other site 931626005636 mobile loop; other site 931626005637 roof hairpin; other site 931626005638 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 931626005639 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 931626005640 hinge regions; other site 931626005641 stacking interactions; other site 931626005642 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626005643 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626005644 B12 binding site [chemical binding]; other site 931626005645 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931626005646 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626005647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626005648 ABC transporter; Region: ABC_tran_2; pfam12848 931626005649 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626005650 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 931626005651 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 931626005652 CoA binding domain; Region: CoA_binding; smart00881 931626005653 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626005654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626005655 non-specific DNA binding site [nucleotide binding]; other site 931626005656 salt bridge; other site 931626005657 sequence-specific DNA binding site [nucleotide binding]; other site 931626005658 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 931626005659 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 931626005660 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 931626005661 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 931626005662 DHHA2 domain; Region: DHHA2; pfam02833 931626005663 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 931626005664 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 931626005665 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 931626005666 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931626005667 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 931626005668 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 931626005669 Competence protein; Region: Competence; pfam03772 931626005670 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 931626005671 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 931626005672 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 931626005673 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 931626005674 GTP-binding protein LepA; Provisional; Region: PRK05433 931626005675 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 931626005676 G1 box; other site 931626005677 putative GEF interaction site [polypeptide binding]; other site 931626005678 GTP/Mg2+ binding site [chemical binding]; other site 931626005679 Switch I region; other site 931626005680 G2 box; other site 931626005681 G3 box; other site 931626005682 Switch II region; other site 931626005683 G4 box; other site 931626005684 G5 box; other site 931626005685 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 931626005686 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 931626005687 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 931626005688 Peptidase M15; Region: Peptidase_M15_3; cl01194 931626005689 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 931626005690 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 931626005691 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 931626005692 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 931626005693 Glycerol kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK; cd07769 931626005694 N- and C-terminal domain interface [polypeptide binding]; other site 931626005695 active site 931626005696 MgATP binding site [chemical binding]; other site 931626005697 catalytic site [active] 931626005698 metal binding site [ion binding]; metal-binding site 931626005699 glycerol binding site [chemical binding]; other site 931626005700 homotetramer interface [polypeptide binding]; other site 931626005701 homodimer interface [polypeptide binding]; other site 931626005702 Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208 931626005703 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626005704 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626005705 B12 binding site [chemical binding]; other site 931626005706 cobalt ligand [ion binding]; other site 931626005707 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 931626005708 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 931626005709 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 931626005710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626005711 active site 931626005712 phosphorylation site [posttranslational modification] 931626005713 intermolecular recognition site; other site 931626005714 dimerization interface [polypeptide binding]; other site 931626005715 LytTr DNA-binding domain; Region: LytTR; smart00850 931626005716 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 931626005717 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 931626005718 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931626005719 putative DNA binding site [nucleotide binding]; other site 931626005720 putative Zn2+ binding site [ion binding]; other site 931626005721 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 931626005722 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 931626005723 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 931626005724 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 931626005725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626005726 motif II; other site 931626005727 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 931626005728 active site 931626005729 nucleotide-binding site [chemical binding]; other site 931626005730 Rubrerythrin [Energy production and conversion]; Region: COG1592 931626005731 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 931626005732 binuclear metal center [ion binding]; other site 931626005733 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 931626005734 iron binding site [ion binding]; other site 931626005735 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 931626005736 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 931626005737 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 931626005738 dimer interface [polypeptide binding]; other site 931626005739 active site 931626005740 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 931626005741 substrate binding site [chemical binding]; other site 931626005742 catalytic residue [active] 931626005743 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 931626005744 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 931626005745 HIGH motif; other site 931626005746 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 931626005747 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931626005748 active site 931626005749 KMSKS motif; other site 931626005750 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 931626005751 tRNA binding surface [nucleotide binding]; other site 931626005752 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 931626005753 RNA/DNA hybrid binding site [nucleotide binding]; other site 931626005754 active site 931626005755 EDD domain protein, DegV family; Region: DegV; TIGR00762 931626005756 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 931626005757 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 931626005758 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 931626005759 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931626005760 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 931626005761 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 931626005762 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 931626005763 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 931626005764 synthetase active site [active] 931626005765 NTP binding site [chemical binding]; other site 931626005766 metal binding site [ion binding]; metal-binding site 931626005767 hypothetical protein; Validated; Region: PRK00110 931626005768 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 931626005769 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 931626005770 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 931626005771 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 931626005772 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 931626005773 putative substrate binding site [chemical binding]; other site 931626005774 putative ATP binding site [chemical binding]; other site 931626005775 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 931626005776 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 931626005777 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 931626005778 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 931626005779 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626005780 FeS/SAM binding site; other site 931626005781 TRAM domain; Region: TRAM; pfam01938 931626005782 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 931626005783 MutS domain I; Region: MutS_I; pfam01624 931626005784 MutS domain II; Region: MutS_II; pfam05188 931626005785 MutS domain III; Region: MutS_III; pfam05192 931626005786 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 931626005787 Walker A/P-loop; other site 931626005788 ATP binding site [chemical binding]; other site 931626005789 Q-loop/lid; other site 931626005790 ABC transporter signature motif; other site 931626005791 Walker B; other site 931626005792 D-loop; other site 931626005793 H-loop/switch region; other site 931626005794 ribonuclease R; Region: RNase_R; TIGR02063 931626005795 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 931626005796 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 931626005797 RNB domain; Region: RNB; pfam00773 931626005798 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 931626005799 RNA binding site [nucleotide binding]; other site 931626005800 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 931626005801 SmpB-tmRNA interface; other site 931626005802 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 931626005803 Y-family of DNA polymerases; Region: PolY; cl12025 931626005804 active site 931626005805 DNA binding site [nucleotide binding] 931626005806 YolD-like protein; Region: YolD; pfam08863 931626005807 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 931626005808 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 931626005809 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 931626005810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626005811 Walker A motif; other site 931626005812 ATP binding site [chemical binding]; other site 931626005813 Walker B motif; other site 931626005814 arginine finger; other site 931626005815 Winged helix-turn helix; Region: HTH_29; pfam13551 931626005816 Homeodomain-like domain; Region: HTH_32; pfam13565 931626005817 Integrase core domain; Region: rve; pfam00665 931626005818 Integrase core domain; Region: rve_3; pfam13683 931626005819 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 931626005820 Transposase; Region: DDE_Tnp_ISL3; pfam01610 931626005821 Fic family protein [Function unknown]; Region: COG3177 931626005822 Fic/DOC family; Region: Fic; pfam02661 931626005823 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931626005824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626005825 S-adenosylmethionine binding site [chemical binding]; other site 931626005826 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 931626005827 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 931626005828 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 931626005829 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931626005830 ATP binding site [chemical binding]; other site 931626005831 putative Mg++ binding site [ion binding]; other site 931626005832 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 931626005833 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 931626005834 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 931626005835 HsdM N-terminal domain; Region: HsdM_N; pfam12161 931626005836 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 931626005837 Methyltransferase domain; Region: Methyltransf_26; pfam13659 931626005838 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 931626005839 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931626005840 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931626005841 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 931626005842 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626005843 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626005844 Clostridial hydrophobic W; Region: ChW; pfam07538 931626005845 Clostridial hydrophobic W; Region: ChW; pfam07538 931626005846 Clostridial hydrophobic W; Region: ChW; pfam07538 931626005847 SnoaL-like domain; Region: SnoaL_2; pfam12680 931626005848 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 931626005849 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 931626005850 synthetase active site [active] 931626005851 NTP binding site [chemical binding]; other site 931626005852 metal binding site [ion binding]; metal-binding site 931626005853 ABC-2 type transporter; Region: ABC2_membrane; cl17235 931626005854 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931626005855 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626005856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626005857 Walker A/P-loop; other site 931626005858 ATP binding site [chemical binding]; other site 931626005859 Q-loop/lid; other site 931626005860 ABC transporter signature motif; other site 931626005861 Walker B; other site 931626005862 D-loop; other site 931626005863 H-loop/switch region; other site 931626005864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626005865 dimer interface [polypeptide binding]; other site 931626005866 phosphorylation site [posttranslational modification] 931626005867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626005868 ATP binding site [chemical binding]; other site 931626005869 Mg2+ binding site [ion binding]; other site 931626005870 G-X-G motif; other site 931626005871 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626005872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626005873 active site 931626005874 phosphorylation site [posttranslational modification] 931626005875 intermolecular recognition site; other site 931626005876 dimerization interface [polypeptide binding]; other site 931626005877 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626005878 DNA binding site [nucleotide binding] 931626005879 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626005880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626005881 active site 931626005882 phosphorylation site [posttranslational modification] 931626005883 intermolecular recognition site; other site 931626005884 dimerization interface [polypeptide binding]; other site 931626005885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626005886 DNA binding site [nucleotide binding] 931626005887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626005888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626005889 dimer interface [polypeptide binding]; other site 931626005890 phosphorylation site [posttranslational modification] 931626005891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626005892 ATP binding site [chemical binding]; other site 931626005893 Mg2+ binding site [ion binding]; other site 931626005894 G-X-G motif; other site 931626005895 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626005896 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626005897 Walker A/P-loop; other site 931626005898 ATP binding site [chemical binding]; other site 931626005899 Q-loop/lid; other site 931626005900 ABC transporter signature motif; other site 931626005901 Walker B; other site 931626005902 D-loop; other site 931626005903 H-loop/switch region; other site 931626005904 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626005905 FtsX-like permease family; Region: FtsX; pfam02687 931626005906 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931626005907 FtsX-like permease family; Region: FtsX; pfam02687 931626005908 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 931626005909 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 931626005910 5S rRNA interface [nucleotide binding]; other site 931626005911 CTC domain interface [polypeptide binding]; other site 931626005912 L16 interface [polypeptide binding]; other site 931626005913 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 931626005914 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 931626005915 G1 box; other site 931626005916 GTP/Mg2+ binding site [chemical binding]; other site 931626005917 Switch I region; other site 931626005918 G2 box; other site 931626005919 G3 box; other site 931626005920 Switch II region; other site 931626005921 G4 box; other site 931626005922 G5 box; other site 931626005923 Nucleoside recognition; Region: Gate; pfam07670 931626005924 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 931626005925 Nucleoside recognition; Region: Gate; pfam07670 931626005926 FeoA domain; Region: FeoA; pfam04023 931626005927 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 931626005928 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931626005929 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 931626005930 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 931626005931 inhibitor-cofactor binding pocket; inhibition site 931626005932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626005933 catalytic residue [active] 931626005934 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 931626005935 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931626005936 active site 931626005937 NAD binding site [chemical binding]; other site 931626005938 metal binding site [ion binding]; metal-binding site 931626005939 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626005940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626005941 non-specific DNA binding site [nucleotide binding]; other site 931626005942 salt bridge; other site 931626005943 sequence-specific DNA binding site [nucleotide binding]; other site 931626005944 Cupin domain; Region: Cupin_2; pfam07883 931626005945 acetylornithine aminotransferase; Provisional; Region: PRK02627 931626005946 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 931626005947 inhibitor-cofactor binding pocket; inhibition site 931626005948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626005949 catalytic residue [active] 931626005950 amino acid transporter; Region: 2A0306; TIGR00909 931626005951 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 931626005952 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 931626005953 active site 931626005954 metal binding site [ion binding]; metal-binding site 931626005955 TIGR04076 family protein; Region: TIGR04076 931626005956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626005957 non-specific DNA binding site [nucleotide binding]; other site 931626005958 salt bridge; other site 931626005959 sequence-specific DNA binding site [nucleotide binding]; other site 931626005960 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626005961 Zn2+ binding site [ion binding]; other site 931626005962 Mg2+ binding site [ion binding]; other site 931626005963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005964 PAS domain; Region: PAS_9; pfam13426 931626005965 putative active site [active] 931626005966 heme pocket [chemical binding]; other site 931626005967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005968 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 931626005969 putative active site [active] 931626005970 heme pocket [chemical binding]; other site 931626005971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626005972 putative active site [active] 931626005973 heme pocket [chemical binding]; other site 931626005974 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626005975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626005976 metal binding site [ion binding]; metal-binding site 931626005977 active site 931626005978 I-site; other site 931626005979 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626005980 Zn2+ binding site [ion binding]; other site 931626005981 Mg2+ binding site [ion binding]; other site 931626005982 Predicted membrane protein [Function unknown]; Region: COG2364 931626005983 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 931626005984 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626005985 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626005986 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 931626005987 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 931626005988 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 931626005989 Cache domain; Region: Cache_1; pfam02743 931626005990 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626005991 dimerization interface [polypeptide binding]; other site 931626005992 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626005993 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626005994 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626005995 dimer interface [polypeptide binding]; other site 931626005996 putative CheW interface [polypeptide binding]; other site 931626005997 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626005998 dimer interface [polypeptide binding]; other site 931626005999 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931626006000 putative CheW interface [polypeptide binding]; other site 931626006001 HAMP domain; Region: HAMP; pfam00672 931626006002 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626006003 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626006004 dimer interface [polypeptide binding]; other site 931626006005 putative CheW interface [polypeptide binding]; other site 931626006006 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 931626006007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626006008 Walker A motif; other site 931626006009 ATP binding site [chemical binding]; other site 931626006010 Walker B motif; other site 931626006011 arginine finger; other site 931626006012 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 931626006013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931626006014 Beta-Casp domain; Region: Beta-Casp; smart01027 931626006015 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 931626006016 PAS fold; Region: PAS_4; pfam08448 931626006017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006018 putative active site [active] 931626006019 heme pocket [chemical binding]; other site 931626006020 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 931626006021 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 931626006022 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 931626006023 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 931626006024 PAS domain; Region: PAS; smart00091 931626006025 PAS fold; Region: PAS_4; pfam08448 931626006026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626006027 dimer interface [polypeptide binding]; other site 931626006028 phosphorylation site [posttranslational modification] 931626006029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626006030 ATP binding site [chemical binding]; other site 931626006031 Mg2+ binding site [ion binding]; other site 931626006032 G-X-G motif; other site 931626006033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626006034 Response regulator receiver domain; Region: Response_reg; pfam00072 931626006035 active site 931626006036 phosphorylation site [posttranslational modification] 931626006037 intermolecular recognition site; other site 931626006038 dimerization interface [polypeptide binding]; other site 931626006039 Response regulator receiver domain; Region: Response_reg; pfam00072 931626006040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626006041 active site 931626006042 phosphorylation site [posttranslational modification] 931626006043 intermolecular recognition site; other site 931626006044 dimerization interface [polypeptide binding]; other site 931626006045 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 931626006046 putative binding surface; other site 931626006047 active site 931626006048 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 931626006049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626006050 active site 931626006051 phosphorylation site [posttranslational modification] 931626006052 intermolecular recognition site; other site 931626006053 dimerization interface [polypeptide binding]; other site 931626006054 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626006055 Zn2+ binding site [ion binding]; other site 931626006056 Mg2+ binding site [ion binding]; other site 931626006057 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931626006058 AzlC protein; Region: AzlC; cl00570 931626006059 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 931626006060 Predicted transcriptional regulators [Transcription]; Region: COG1378 931626006061 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 931626006062 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 931626006063 C-terminal domain interface [polypeptide binding]; other site 931626006064 sugar binding site [chemical binding]; other site 931626006065 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 931626006066 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 931626006067 active site 931626006068 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 931626006069 substrate binding site [chemical binding]; other site 931626006070 catalytic residues [active] 931626006071 dimer interface [polypeptide binding]; other site 931626006072 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 931626006073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626006074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626006075 homodimer interface [polypeptide binding]; other site 931626006076 catalytic residue [active] 931626006077 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 931626006078 Malic enzyme, N-terminal domain; Region: malic; pfam00390 931626006079 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 931626006080 putative NAD(P) binding site [chemical binding]; other site 931626006081 heat shock protein 90; Provisional; Region: PRK05218 931626006082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626006083 ATP binding site [chemical binding]; other site 931626006084 Mg2+ binding site [ion binding]; other site 931626006085 G-X-G motif; other site 931626006086 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931626006087 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626006088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626006089 ABC transporter; Region: ABC_tran_2; pfam12848 931626006090 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626006091 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 931626006092 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 931626006093 4Fe-4S binding domain; Region: Fer4; pfam00037 931626006094 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 931626006095 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 931626006096 FAD binding pocket [chemical binding]; other site 931626006097 FAD binding motif [chemical binding]; other site 931626006098 phosphate binding motif [ion binding]; other site 931626006099 beta-alpha-beta structure motif; other site 931626006100 NAD binding pocket [chemical binding]; other site 931626006101 Iron coordination center [ion binding]; other site 931626006102 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 931626006103 hybrid cluster protein; Provisional; Region: PRK05290 931626006104 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626006105 CODH interaction site; other site 931626006106 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 931626006107 hybrid metal cluster; other site 931626006108 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 931626006109 GAF domain; Region: GAF; cl17456 931626006110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626006111 ABC transporter signature motif; other site 931626006112 Walker B; other site 931626006113 D-loop; other site 931626006114 H-loop/switch region; other site 931626006115 Soluble P-type ATPase [General function prediction only]; Region: COG4087 931626006116 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 931626006117 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 931626006118 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 931626006119 putative N- and C-terminal domain interface [polypeptide binding]; other site 931626006120 putative active site [active] 931626006121 MgATP binding site [chemical binding]; other site 931626006122 catalytic site [active] 931626006123 metal binding site [ion binding]; metal-binding site 931626006124 putative xylulose binding site [chemical binding]; other site 931626006125 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 931626006126 classical (c) SDRs; Region: SDR_c; cd05233 931626006127 NAD(P) binding site [chemical binding]; other site 931626006128 active site 931626006129 Predicted dehydrogenase [General function prediction only]; Region: COG0579 931626006130 hydroxyglutarate oxidase; Provisional; Region: PRK11728 931626006131 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931626006132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931626006133 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626006134 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 931626006135 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 931626006136 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 931626006137 intersubunit interface [polypeptide binding]; other site 931626006138 active site 931626006139 zinc binding site [ion binding]; other site 931626006140 Na+ binding site [ion binding]; other site 931626006141 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 931626006142 dinuclear metal binding motif [ion binding]; other site 931626006143 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626006144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626006145 non-specific DNA binding site [nucleotide binding]; other site 931626006146 salt bridge; other site 931626006147 sequence-specific DNA binding site [nucleotide binding]; other site 931626006148 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 931626006149 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 931626006150 glycosyltransferase, MGT family; Region: MGT; TIGR01426 931626006151 active site 931626006152 TDP-binding site; other site 931626006153 acceptor substrate-binding pocket; other site 931626006154 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 931626006155 active site 931626006156 catalytic site [active] 931626006157 substrate binding site [chemical binding]; other site 931626006158 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 931626006159 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 931626006160 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931626006161 ATP binding site [chemical binding]; other site 931626006162 putative Mg++ binding site [ion binding]; other site 931626006163 HsdM N-terminal domain; Region: HsdM_N; pfam12161 931626006164 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 931626006165 PAS fold; Region: PAS_3; pfam08447 931626006166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006167 PAS fold; Region: PAS_3; pfam08447 931626006168 putative active site [active] 931626006169 heme pocket [chemical binding]; other site 931626006170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006171 PAS fold; Region: PAS_3; pfam08447 931626006172 putative active site [active] 931626006173 heme pocket [chemical binding]; other site 931626006174 PAS domain; Region: PAS_9; pfam13426 931626006175 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006176 putative active site [active] 931626006177 heme pocket [chemical binding]; other site 931626006178 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006179 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006180 metal binding site [ion binding]; metal-binding site 931626006181 active site 931626006182 I-site; other site 931626006183 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626006184 PilZ domain; Region: PilZ; pfam07238 931626006185 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006186 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006187 active site 931626006188 I-site; other site 931626006189 metal binding site [ion binding]; metal-binding site 931626006190 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 931626006191 TspO/MBR family; Region: TspO_MBR; cl01379 931626006192 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626006193 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626006194 Clostridial hydrophobic W; Region: ChW; pfam07538 931626006195 Clostridial hydrophobic W; Region: ChW; pfam07538 931626006196 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 931626006197 putative active site [active] 931626006198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006199 PAS fold; Region: PAS_3; pfam08447 931626006200 putative active site [active] 931626006201 heme pocket [chemical binding]; other site 931626006202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006203 PAS domain; Region: PAS_9; pfam13426 931626006204 putative active site [active] 931626006205 heme pocket [chemical binding]; other site 931626006206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006208 metal binding site [ion binding]; metal-binding site 931626006209 active site 931626006210 I-site; other site 931626006211 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 931626006212 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626006213 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931626006214 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 931626006215 active site 931626006216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 931626006217 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626006218 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626006219 Clostridial hydrophobic W; Region: ChW; pfam07538 931626006220 Clostridial hydrophobic W; Region: ChW; pfam07538 931626006221 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 931626006222 G1 box; other site 931626006223 GTP/Mg2+ binding site [chemical binding]; other site 931626006224 G2 box; other site 931626006225 Switch I region; other site 931626006226 G3 box; other site 931626006227 Switch II region; other site 931626006228 G4 box; other site 931626006229 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 931626006230 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 931626006231 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 931626006232 Methyl-coenzyme M reductase operon protein C; Region: MCR_C; cl01674 931626006233 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 931626006234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931626006235 ATP binding site [chemical binding]; other site 931626006236 putative Mg++ binding site [ion binding]; other site 931626006237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931626006238 nucleotide binding region [chemical binding]; other site 931626006239 ATP-binding site [chemical binding]; other site 931626006240 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 931626006241 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 931626006242 Part of AAA domain; Region: AAA_19; pfam13245 931626006243 Family description; Region: UvrD_C_2; pfam13538 931626006244 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931626006245 conjugal transfer protein TraV; Provisional; Region: PRK13733 931626006246 ATP-dependent protease HslVU, ATPase subunit; Region: hslU; TIGR00390 931626006247 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 931626006248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626006249 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626006250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626006251 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 931626006252 active site 931626006253 catalytic site [active] 931626006254 substrate binding site [chemical binding]; other site 931626006255 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 931626006256 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 931626006257 active site 931626006258 catalytic residues [active] 931626006259 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626006260 Clostridial hydrophobic W; Region: ChW; pfam07538 931626006261 Clostridial hydrophobic W; Region: ChW; pfam07538 931626006262 Clostridial hydrophobic W; Region: ChW; pfam07538 931626006263 GAF domain; Region: GAF; pfam01590 931626006264 PAS domain S-box; Region: sensory_box; TIGR00229 931626006265 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006266 putative active site [active] 931626006267 heme pocket [chemical binding]; other site 931626006268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006269 PAS fold; Region: PAS_3; pfam08447 931626006270 putative active site [active] 931626006271 heme pocket [chemical binding]; other site 931626006272 PAS domain S-box; Region: sensory_box; TIGR00229 931626006273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006274 putative active site [active] 931626006275 heme pocket [chemical binding]; other site 931626006276 PAS domain; Region: PAS_8; pfam13188 931626006277 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 931626006278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626006279 dimer interface [polypeptide binding]; other site 931626006280 phosphorylation site [posttranslational modification] 931626006281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626006282 ATP binding site [chemical binding]; other site 931626006283 Mg2+ binding site [ion binding]; other site 931626006284 G-X-G motif; other site 931626006285 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 931626006286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626006287 active site 931626006288 phosphorylation site [posttranslational modification] 931626006289 intermolecular recognition site; other site 931626006290 dimerization interface [polypeptide binding]; other site 931626006291 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626006292 Zn2+ binding site [ion binding]; other site 931626006293 Mg2+ binding site [ion binding]; other site 931626006294 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 931626006295 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 931626006296 dimer interface [polypeptide binding]; other site 931626006297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626006298 catalytic residue [active] 931626006299 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 931626006300 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 931626006301 catalytic residues [active] 931626006302 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 931626006303 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 931626006304 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 931626006305 Part of AAA domain; Region: AAA_19; pfam13245 931626006306 Family description; Region: UvrD_C_2; pfam13538 931626006307 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626006308 dimerization interface [polypeptide binding]; other site 931626006309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626006310 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626006311 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626006312 dimer interface [polypeptide binding]; other site 931626006313 putative CheW interface [polypeptide binding]; other site 931626006314 OPT oligopeptide transporter protein; Region: OPT; cl14607 931626006315 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 931626006316 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 931626006317 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006318 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006319 metal binding site [ion binding]; metal-binding site 931626006320 active site 931626006321 I-site; other site 931626006322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626006323 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 931626006324 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626006325 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626006326 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626006327 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626006328 B12 binding site [chemical binding]; other site 931626006329 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626006330 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 931626006331 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 931626006332 substrate binding pocket [chemical binding]; other site 931626006333 dimer interface [polypeptide binding]; other site 931626006334 inhibitor binding site; inhibition site 931626006335 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 931626006336 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626006337 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626006338 B12 binding site [chemical binding]; other site 931626006339 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 931626006340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626006341 DNA-binding site [nucleotide binding]; DNA binding site 931626006342 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 931626006343 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 931626006344 active site 931626006345 catalytic triad [active] 931626006346 oxyanion hole [active] 931626006347 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 931626006348 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 931626006349 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 931626006350 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 931626006351 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 931626006352 ligand binding site [chemical binding]; other site 931626006353 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 931626006354 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 931626006355 ligand binding site [chemical binding]; other site 931626006356 K-Cl cotransporter; Region: 2a30; TIGR00930 931626006357 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626006358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 931626006359 dimerization interface [polypeptide binding]; other site 931626006360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931626006361 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 931626006362 active site 931626006363 catalytic tetrad [active] 931626006364 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626006365 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 931626006366 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 931626006367 classical (c) SDRs; Region: SDR_c; cd05233 931626006368 NAD(P) binding site [chemical binding]; other site 931626006369 active site 931626006370 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 931626006371 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931626006372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626006373 S-adenosylmethionine binding site [chemical binding]; other site 931626006374 Flavoprotein; Region: Flavoprotein; pfam02441 931626006375 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 931626006376 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931626006377 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931626006378 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 931626006379 active site 931626006380 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 931626006381 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626006382 Clostridial hydrophobic W; Region: ChW; pfam07538 931626006383 Clostridial hydrophobic W; Region: ChW; pfam07538 931626006384 Clostridial hydrophobic W; Region: ChW; pfam07538 931626006385 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931626006386 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626006387 dimerization interface [polypeptide binding]; other site 931626006388 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006389 PAS domain; Region: PAS_9; pfam13426 931626006390 putative active site [active] 931626006391 heme pocket [chemical binding]; other site 931626006392 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626006393 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626006394 dimer interface [polypeptide binding]; other site 931626006395 putative CheW interface [polypeptide binding]; other site 931626006396 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931626006397 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 931626006398 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 931626006399 active site 931626006400 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931626006401 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626006402 dimerization interface [polypeptide binding]; other site 931626006403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006404 PAS domain; Region: PAS_9; pfam13426 931626006405 putative active site [active] 931626006406 heme pocket [chemical binding]; other site 931626006407 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626006408 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626006409 dimer interface [polypeptide binding]; other site 931626006410 putative CheW interface [polypeptide binding]; other site 931626006411 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006412 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006413 metal binding site [ion binding]; metal-binding site 931626006414 active site 931626006415 I-site; other site 931626006416 Cupin domain; Region: Cupin_2; cl17218 931626006417 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 931626006418 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 931626006419 putative dimer interface [polypeptide binding]; other site 931626006420 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 931626006421 Sensory domain found in PocR; Region: PocR; pfam10114 931626006422 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006423 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 931626006424 putative active site [active] 931626006425 heme pocket [chemical binding]; other site 931626006426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006427 putative active site [active] 931626006428 heme pocket [chemical binding]; other site 931626006429 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006431 metal binding site [ion binding]; metal-binding site 931626006432 active site 931626006433 I-site; other site 931626006434 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626006435 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626006436 Zn2+ binding site [ion binding]; other site 931626006437 Mg2+ binding site [ion binding]; other site 931626006438 hypothetical protein; Reviewed; Region: PRK00024 931626006439 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 931626006440 MPN+ (JAMM) motif; other site 931626006441 Zinc-binding site [ion binding]; other site 931626006442 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 931626006443 PLD-like domain; Region: PLDc_2; pfam13091 931626006444 putative homodimer interface [polypeptide binding]; other site 931626006445 putative active site [active] 931626006446 catalytic site [active] 931626006447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626006448 AAA domain; Region: AAA_21; pfam13304 931626006449 Walker A/P-loop; other site 931626006450 ATP binding site [chemical binding]; other site 931626006451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626006452 Walker B; other site 931626006453 D-loop; other site 931626006454 H-loop/switch region; other site 931626006455 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 931626006456 cofactor binding site; other site 931626006457 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 931626006458 DNA binding site [nucleotide binding] 931626006459 substrate interaction site [chemical binding]; other site 931626006460 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 931626006461 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 931626006462 cofactor binding site; other site 931626006463 DNA binding site [nucleotide binding] 931626006464 substrate interaction site [chemical binding]; other site 931626006465 EcoRII C terminal; Region: EcoRII-C; pfam09019 931626006466 Nuclease-related domain; Region: NERD; pfam08378 931626006467 HRDC domain; Region: HRDC; pfam00570 931626006468 Nuclease-related domain; Region: NERD; pfam08378 931626006469 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 931626006470 Flavodoxin domain; Region: Flavodoxin_5; cl17428 931626006471 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626006472 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 931626006473 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 931626006474 putative binding surface; other site 931626006475 active site 931626006476 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 931626006477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626006478 ATP binding site [chemical binding]; other site 931626006479 Mg2+ binding site [ion binding]; other site 931626006480 G-X-G motif; other site 931626006481 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 931626006482 CheW-like domain; Region: CheW; pfam01584 931626006483 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931626006484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626006485 active site 931626006486 phosphorylation site [posttranslational modification] 931626006487 intermolecular recognition site; other site 931626006488 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 931626006489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626006490 dimerization interface [polypeptide binding]; other site 931626006491 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626006492 dimer interface [polypeptide binding]; other site 931626006493 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626006494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626006495 dimer interface [polypeptide binding]; other site 931626006496 putative CheW interface [polypeptide binding]; other site 931626006497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626006498 dimer interface [polypeptide binding]; other site 931626006499 putative CheW interface [polypeptide binding]; other site 931626006500 CheB methylesterase; Region: CheB_methylest; pfam01339 931626006501 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 931626006502 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 931626006503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626006504 Response regulator receiver domain; Region: Response_reg; pfam00072 931626006505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626006506 active site 931626006507 phosphorylation site [posttranslational modification] 931626006508 intermolecular recognition site; other site 931626006509 dimerization interface [polypeptide binding]; other site 931626006510 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 931626006511 Response regulator receiver domain; Region: Response_reg; pfam00072 931626006512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626006513 active site 931626006514 phosphorylation site [posttranslational modification] 931626006515 intermolecular recognition site; other site 931626006516 dimerization interface [polypeptide binding]; other site 931626006517 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006519 metal binding site [ion binding]; metal-binding site 931626006520 active site 931626006521 I-site; other site 931626006522 Response regulator receiver domain; Region: Response_reg; pfam00072 931626006523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626006524 active site 931626006525 phosphorylation site [posttranslational modification] 931626006526 intermolecular recognition site; other site 931626006527 dimerization interface [polypeptide binding]; other site 931626006528 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 931626006529 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 931626006530 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 931626006531 acyl-activating enzyme (AAE) consensus motif; other site 931626006532 AMP binding site [chemical binding]; other site 931626006533 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931626006534 Condensation domain; Region: Condensation; pfam00668 931626006535 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 931626006536 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 931626006537 acyl-activating enzyme (AAE) consensus motif; other site 931626006538 AMP binding site [chemical binding]; other site 931626006539 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931626006540 thioester reductase domain; Region: Thioester-redct; TIGR01746 931626006541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931626006542 NAD(P) binding site [chemical binding]; other site 931626006543 active site 931626006544 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 931626006545 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 931626006546 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 931626006547 PAS domain; Region: PAS_9; pfam13426 931626006548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006549 putative active site [active] 931626006550 heme pocket [chemical binding]; other site 931626006551 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006552 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006553 metal binding site [ion binding]; metal-binding site 931626006554 active site 931626006555 I-site; other site 931626006556 Late competence development protein ComFB; Region: ComFB; pfam10719 931626006557 aspartate kinase; Reviewed; Region: PRK06635 931626006558 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 931626006559 putative catalytic residues [active] 931626006560 putative nucleotide binding site [chemical binding]; other site 931626006561 putative aspartate binding site [chemical binding]; other site 931626006562 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891 931626006563 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 931626006564 putative allosteric regulatory residue; other site 931626006565 dihydrodipicolinate reductase; Provisional; Region: PRK00048 931626006566 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 931626006567 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 931626006568 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 931626006569 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 931626006570 dimer interface [polypeptide binding]; other site 931626006571 active site 931626006572 catalytic residue [active] 931626006573 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 931626006574 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 931626006575 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 931626006576 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 931626006577 dimerization domain swap beta strand [polypeptide binding]; other site 931626006578 regulatory protein interface [polypeptide binding]; other site 931626006579 active site 931626006580 regulatory phosphorylation site [posttranslational modification]; other site 931626006581 cobalamin synthase; Reviewed; Region: cobS; PRK00235 931626006582 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 931626006583 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 931626006584 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 931626006585 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 931626006586 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 931626006587 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 931626006588 TRAM domain; Region: TRAM; pfam01938 931626006589 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 931626006590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626006591 S-adenosylmethionine binding site [chemical binding]; other site 931626006592 Fic/DOC family; Region: Fic; pfam02661 931626006593 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 931626006594 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 931626006595 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 931626006596 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006597 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006598 metal binding site [ion binding]; metal-binding site 931626006599 active site 931626006600 I-site; other site 931626006601 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 931626006602 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 931626006603 putative binding surface; other site 931626006604 active site 931626006605 P2 response regulator binding domain; Region: P2; pfam07194 931626006606 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 931626006607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626006608 ATP binding site [chemical binding]; other site 931626006609 Mg2+ binding site [ion binding]; other site 931626006610 G-X-G motif; other site 931626006611 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 931626006612 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 931626006613 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931626006614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626006615 dimerization interface [polypeptide binding]; other site 931626006616 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626006617 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626006618 dimer interface [polypeptide binding]; other site 931626006619 putative CheW interface [polypeptide binding]; other site 931626006620 PAS fold; Region: PAS_4; pfam08448 931626006621 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006622 putative active site [active] 931626006623 heme pocket [chemical binding]; other site 931626006624 PAS domain; Region: PAS; smart00091 931626006625 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 931626006626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626006627 putative active site [active] 931626006628 heme pocket [chemical binding]; other site 931626006629 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 931626006630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626006631 dimer interface [polypeptide binding]; other site 931626006632 phosphorylation site [posttranslational modification] 931626006633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626006634 ATP binding site [chemical binding]; other site 931626006635 Mg2+ binding site [ion binding]; other site 931626006636 G-X-G motif; other site 931626006637 Response regulator receiver domain; Region: Response_reg; pfam00072 931626006638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626006639 active site 931626006640 phosphorylation site [posttranslational modification] 931626006641 intermolecular recognition site; other site 931626006642 dimerization interface [polypeptide binding]; other site 931626006643 Response regulator receiver domain; Region: Response_reg; pfam00072 931626006644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626006645 active site 931626006646 phosphorylation site [posttranslational modification] 931626006647 intermolecular recognition site; other site 931626006648 dimerization interface [polypeptide binding]; other site 931626006649 Hemerythrin; Region: Hemerythrin; cd12107 931626006650 Fe binding site [ion binding]; other site 931626006651 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 931626006652 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 931626006653 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 931626006654 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626006655 PAS fold; Region: PAS_4; pfam08448 931626006656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 931626006657 putative active site [active] 931626006658 heme pocket [chemical binding]; other site 931626006659 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006660 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006661 metal binding site [ion binding]; metal-binding site 931626006662 active site 931626006663 I-site; other site 931626006664 Predicted methyltransferase [General function prediction only]; Region: COG2520 931626006665 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931626006666 dimerization interface [polypeptide binding]; other site 931626006667 putative DNA binding site [nucleotide binding]; other site 931626006668 putative Zn2+ binding site [ion binding]; other site 931626006669 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 931626006670 metal binding site 2 [ion binding]; metal-binding site 931626006671 putative DNA binding helix; other site 931626006672 metal binding site 1 [ion binding]; metal-binding site 931626006673 structural Zn2+ binding site [ion binding]; other site 931626006674 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 931626006675 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626006676 ACS interaction site; other site 931626006677 CODH interaction site; other site 931626006678 metal cluster binding site [ion binding]; other site 931626006679 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626006680 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626006681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931626006682 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626006683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626006684 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 931626006685 active site 931626006686 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 931626006687 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 931626006688 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 931626006689 Hexamer interface [polypeptide binding]; other site 931626006690 Hexagonal pore residue; other site 931626006691 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 931626006692 Hexamer interface [polypeptide binding]; other site 931626006693 Hexagonal pore residue; other site 931626006694 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 931626006695 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 931626006696 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 931626006697 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 931626006698 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 931626006699 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 931626006700 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 931626006701 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 931626006702 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 931626006703 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 931626006704 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 931626006705 carboxyltransferase (CT) interaction site; other site 931626006706 biotinylation site [posttranslational modification]; other site 931626006707 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 931626006708 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 931626006709 dimer interface [polypeptide binding]; other site 931626006710 active site 931626006711 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 931626006712 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 931626006713 NAD(P) binding site [chemical binding]; other site 931626006714 homotetramer interface [polypeptide binding]; other site 931626006715 homodimer interface [polypeptide binding]; other site 931626006716 active site 931626006717 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 931626006718 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 931626006719 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 931626006720 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 931626006721 FMN binding site [chemical binding]; other site 931626006722 substrate binding site [chemical binding]; other site 931626006723 putative catalytic residue [active] 931626006724 Phosphopantetheine attachment site; Region: PP-binding; cl09936 931626006725 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 931626006726 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 931626006727 dimer interface [polypeptide binding]; other site 931626006728 active site 931626006729 CoA binding pocket [chemical binding]; other site 931626006730 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626006731 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931626006732 putative Zn2+ binding site [ion binding]; other site 931626006733 putative DNA binding site [nucleotide binding]; other site 931626006734 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 931626006735 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 931626006736 FMN binding site [chemical binding]; other site 931626006737 substrate binding site [chemical binding]; other site 931626006738 putative catalytic residue [active] 931626006739 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931626006740 EamA-like transporter family; Region: EamA; pfam00892 931626006741 EamA-like transporter family; Region: EamA; pfam00892 931626006742 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 931626006743 catalytic core [active] 931626006744 metal-binding heat shock protein; Provisional; Region: PRK00016 931626006745 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 931626006746 GTPase Era; Reviewed; Region: era; PRK00089 931626006747 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 931626006748 G1 box; other site 931626006749 GTP/Mg2+ binding site [chemical binding]; other site 931626006750 Switch I region; other site 931626006751 G2 box; other site 931626006752 Switch II region; other site 931626006753 G3 box; other site 931626006754 G4 box; other site 931626006755 G5 box; other site 931626006756 KH domain; Region: KH_2; pfam07650 931626006757 Recombination protein O N terminal; Region: RecO_N; pfam11967 931626006758 DNA repair protein RecO; Region: reco; TIGR00613 931626006759 Recombination protein O C terminal; Region: RecO_C; pfam02565 931626006760 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 931626006761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626006762 dimerization interface [polypeptide binding]; other site 931626006763 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626006764 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626006765 metal binding site [ion binding]; metal-binding site 931626006766 active site 931626006767 I-site; other site 931626006768 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626006769 Zn2+ binding site [ion binding]; other site 931626006770 Mg2+ binding site [ion binding]; other site 931626006771 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931626006772 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 931626006773 dimer interface [polypeptide binding]; other site 931626006774 active site 931626006775 metal binding site [ion binding]; metal-binding site 931626006776 glutathione binding site [chemical binding]; other site 931626006777 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 931626006778 EDD domain protein, DegV family; Region: DegV; TIGR00762 931626006779 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 931626006780 DNA protecting protein DprA; Region: dprA; TIGR00732 931626006781 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 931626006782 DNA topoisomerase I; Validated; Region: PRK05582 931626006783 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 931626006784 active site 931626006785 interdomain interaction site; other site 931626006786 putative metal-binding site [ion binding]; other site 931626006787 nucleotide binding site [chemical binding]; other site 931626006788 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 931626006789 domain I; other site 931626006790 DNA binding groove [nucleotide binding] 931626006791 phosphate binding site [ion binding]; other site 931626006792 domain II; other site 931626006793 domain III; other site 931626006794 nucleotide binding site [chemical binding]; other site 931626006795 catalytic site [active] 931626006796 domain IV; other site 931626006797 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 931626006798 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 931626006799 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 931626006800 active site 931626006801 HslU subunit interaction site [polypeptide binding]; other site 931626006802 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 931626006803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626006804 Walker A motif; other site 931626006805 ATP binding site [chemical binding]; other site 931626006806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 931626006807 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 931626006808 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 931626006809 rRNA interaction site [nucleotide binding]; other site 931626006810 S8 interaction site; other site 931626006811 putative laminin-1 binding site; other site 931626006812 UBA/TS-N domain; Region: UBA; pfam00627 931626006813 elongation factor Ts; Reviewed; Region: tsf; PRK12332 931626006814 Elongation factor TS; Region: EF_TS; pfam00889 931626006815 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 931626006816 putative nucleotide binding site [chemical binding]; other site 931626006817 uridine monophosphate binding site [chemical binding]; other site 931626006818 homohexameric interface [polypeptide binding]; other site 931626006819 ribosome recycling factor; Reviewed; Region: frr; PRK00083 931626006820 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 931626006821 hinge region; other site 931626006822 ribosome maturation protein RimP; Reviewed; Region: PRK00092 931626006823 Sm and related proteins; Region: Sm_like; cl00259 931626006824 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 931626006825 putative oligomer interface [polypeptide binding]; other site 931626006826 putative RNA binding site [nucleotide binding]; other site 931626006827 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 931626006828 NusA N-terminal domain; Region: NusA_N; pfam08529 931626006829 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 931626006830 RNA binding site [nucleotide binding]; other site 931626006831 homodimer interface [polypeptide binding]; other site 931626006832 NusA-like KH domain; Region: KH_5; pfam13184 931626006833 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 931626006834 G-X-X-G motif; other site 931626006835 translation initiation factor IF-2; Validated; Region: infB; PRK05306 931626006836 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 931626006837 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 931626006838 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 931626006839 G1 box; other site 931626006840 putative GEF interaction site [polypeptide binding]; other site 931626006841 GTP/Mg2+ binding site [chemical binding]; other site 931626006842 Switch I region; other site 931626006843 G2 box; other site 931626006844 G3 box; other site 931626006845 Switch II region; other site 931626006846 G4 box; other site 931626006847 G5 box; other site 931626006848 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 931626006849 Translation-initiation factor 2; Region: IF-2; pfam11987 931626006850 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 931626006851 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 931626006852 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 931626006853 DHH family; Region: DHH; pfam01368 931626006854 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 931626006855 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 931626006856 RNA binding site [nucleotide binding]; other site 931626006857 active site 931626006858 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 931626006859 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 931626006860 active site 931626006861 Riboflavin kinase; Region: Flavokinase; pfam01687 931626006862 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 931626006863 16S/18S rRNA binding site [nucleotide binding]; other site 931626006864 S13e-L30e interaction site [polypeptide binding]; other site 931626006865 25S rRNA binding site [nucleotide binding]; other site 931626006866 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 931626006867 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 931626006868 RNase E interface [polypeptide binding]; other site 931626006869 trimer interface [polypeptide binding]; other site 931626006870 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 931626006871 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 931626006872 RNase E interface [polypeptide binding]; other site 931626006873 trimer interface [polypeptide binding]; other site 931626006874 active site 931626006875 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 931626006876 putative nucleic acid binding region [nucleotide binding]; other site 931626006877 G-X-X-G motif; other site 931626006878 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 931626006879 RNA binding site [nucleotide binding]; other site 931626006880 domain interface; other site 931626006881 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 931626006882 trimer interface [polypeptide binding]; other site 931626006883 active site 931626006884 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 931626006885 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 931626006886 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 931626006887 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 931626006888 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 931626006889 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626006890 FeS/SAM binding site; other site 931626006891 competence damage-inducible protein A; Provisional; Region: PRK00549 931626006892 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 931626006893 putative MPT binding site; other site 931626006894 Competence-damaged protein; Region: CinA; pfam02464 931626006895 recombinase A; Provisional; Region: recA; PRK09354 931626006896 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 931626006897 hexamer interface [polypeptide binding]; other site 931626006898 Walker A motif; other site 931626006899 ATP binding site [chemical binding]; other site 931626006900 Walker B motif; other site 931626006901 phosphodiesterase; Provisional; Region: PRK12704 931626006902 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626006903 Zn2+ binding site [ion binding]; other site 931626006904 Mg2+ binding site [ion binding]; other site 931626006905 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 931626006906 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 931626006907 putative active site [active] 931626006908 metal binding site [ion binding]; metal-binding site 931626006909 homodimer binding site [polypeptide binding]; other site 931626006910 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 931626006911 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 931626006912 tetramer interface [polypeptide binding]; other site 931626006913 active site 931626006914 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 931626006915 dimer interface [polypeptide binding]; other site 931626006916 Citrate synthase; Region: Citrate_synt; pfam00285 931626006917 active site 931626006918 citrylCoA binding site [chemical binding]; other site 931626006919 oxalacetate/citrate binding site [chemical binding]; other site 931626006920 coenzyme A binding site [chemical binding]; other site 931626006921 catalytic triad [active] 931626006922 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 931626006923 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 931626006924 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 931626006925 dimer interface [polypeptide binding]; other site 931626006926 PYR/PP interface [polypeptide binding]; other site 931626006927 TPP binding site [chemical binding]; other site 931626006928 substrate binding site [chemical binding]; other site 931626006929 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 931626006930 TPP-binding site; other site 931626006931 4Fe-4S binding domain; Region: Fer4; pfam00037 931626006932 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 931626006933 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 931626006934 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 931626006935 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 931626006936 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 931626006937 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 931626006938 active site 931626006939 dimer interface [polypeptide binding]; other site 931626006940 effector binding site; other site 931626006941 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 931626006942 TSCPD domain; Region: TSCPD; pfam12637 931626006943 gamma-glutamyl kinase; Provisional; Region: PRK05429 931626006944 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 931626006945 nucleotide binding site [chemical binding]; other site 931626006946 homotetrameric interface [polypeptide binding]; other site 931626006947 putative phosphate binding site [ion binding]; other site 931626006948 putative allosteric binding site; other site 931626006949 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 931626006950 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 931626006951 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 931626006952 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 931626006953 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931626006954 active site 931626006955 HIGH motif; other site 931626006956 nucleotide binding site [chemical binding]; other site 931626006957 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 931626006958 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 931626006959 active site 931626006960 KMSKS motif; other site 931626006961 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 931626006962 tRNA binding surface [nucleotide binding]; other site 931626006963 anticodon binding site; other site 931626006964 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 931626006965 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 931626006966 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 931626006967 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 931626006968 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 931626006969 Protein of unknown function (DUF512); Region: DUF512; pfam04459 931626006970 GTP-binding protein Der; Reviewed; Region: PRK00093 931626006971 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 931626006972 G1 box; other site 931626006973 GTP/Mg2+ binding site [chemical binding]; other site 931626006974 Switch I region; other site 931626006975 G2 box; other site 931626006976 Switch II region; other site 931626006977 G3 box; other site 931626006978 G4 box; other site 931626006979 G5 box; other site 931626006980 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 931626006981 G1 box; other site 931626006982 GTP/Mg2+ binding site [chemical binding]; other site 931626006983 Switch I region; other site 931626006984 G2 box; other site 931626006985 G3 box; other site 931626006986 Switch II region; other site 931626006987 G4 box; other site 931626006988 G5 box; other site 931626006989 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 931626006990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931626006991 Transposase; Region: HTH_Tnp_1; pfam01527 931626006992 putative transposase OrfB; Reviewed; Region: PHA02517 931626006993 HTH-like domain; Region: HTH_21; pfam13276 931626006994 Integrase core domain; Region: rve; pfam00665 931626006995 Integrase core domain; Region: rve_3; pfam13683 931626006996 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 931626006997 active site 931626006998 NTP binding site [chemical binding]; other site 931626006999 metal binding triad [ion binding]; metal-binding site 931626007000 SEC-C motif; Region: SEC-C; pfam02810 931626007001 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 931626007002 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931626007003 active site 931626007004 DNA binding site [nucleotide binding] 931626007005 Int/Topo IB signature motif; other site 931626007006 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 931626007007 LexA repressor; Validated; Region: PRK00215 931626007008 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 931626007009 Catalytic site [active] 931626007010 Cell division protein ZapA; Region: ZapA; pfam05164 931626007011 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 931626007012 DNA protecting protein DprA; Region: dprA; TIGR00732 931626007013 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 931626007014 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 931626007015 putative tRNA-binding site [nucleotide binding]; other site 931626007016 B3/4 domain; Region: B3_4; pfam03483 931626007017 tRNA synthetase B5 domain; Region: B5; smart00874 931626007018 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 931626007019 dimer interface [polypeptide binding]; other site 931626007020 motif 1; other site 931626007021 motif 3; other site 931626007022 motif 2; other site 931626007023 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 931626007024 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 931626007025 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 931626007026 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 931626007027 dimer interface [polypeptide binding]; other site 931626007028 motif 1; other site 931626007029 active site 931626007030 motif 2; other site 931626007031 motif 3; other site 931626007032 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 931626007033 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 931626007034 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 931626007035 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 931626007036 TrkA-N domain; Region: TrkA_N; pfam02254 931626007037 TrkA-C domain; Region: TrkA_C; pfam02080 931626007038 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 931626007039 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 931626007040 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 931626007041 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 931626007042 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 931626007043 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 931626007044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626007045 Walker A/P-loop; other site 931626007046 ATP binding site [chemical binding]; other site 931626007047 Q-loop/lid; other site 931626007048 ABC transporter signature motif; other site 931626007049 Walker B; other site 931626007050 D-loop; other site 931626007051 H-loop/switch region; other site 931626007052 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931626007053 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 931626007054 TM-ABC transporter signature motif; other site 931626007055 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 931626007056 zinc binding site [ion binding]; other site 931626007057 putative ligand binding site [chemical binding]; other site 931626007058 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 931626007059 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 931626007060 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 931626007061 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 931626007062 active site 931626007063 dimer interface [polypeptide binding]; other site 931626007064 motif 1; other site 931626007065 motif 2; other site 931626007066 motif 3; other site 931626007067 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 931626007068 anticodon binding site; other site 931626007069 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 931626007070 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 931626007071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626007072 FeS/SAM binding site; other site 931626007073 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 931626007074 GTP-binding protein YchF; Reviewed; Region: PRK09601 931626007075 YchF GTPase; Region: YchF; cd01900 931626007076 G1 box; other site 931626007077 GTP/Mg2+ binding site [chemical binding]; other site 931626007078 Switch I region; other site 931626007079 G2 box; other site 931626007080 Switch II region; other site 931626007081 G3 box; other site 931626007082 G4 box; other site 931626007083 G5 box; other site 931626007084 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 931626007085 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 931626007086 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626007087 Zn2+ binding site [ion binding]; other site 931626007088 Mg2+ binding site [ion binding]; other site 931626007089 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 931626007090 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 931626007091 active site 931626007092 (T/H)XGH motif; other site 931626007093 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 931626007094 GTPase CgtA; Reviewed; Region: obgE; PRK12297 931626007095 GTP1/OBG; Region: GTP1_OBG; pfam01018 931626007096 Obg GTPase; Region: Obg; cd01898 931626007097 G1 box; other site 931626007098 GTP/Mg2+ binding site [chemical binding]; other site 931626007099 Switch I region; other site 931626007100 G2 box; other site 931626007101 G3 box; other site 931626007102 Switch II region; other site 931626007103 G4 box; other site 931626007104 G5 box; other site 931626007105 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 931626007106 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 931626007107 Protein of unknown function (DUF464); Region: DUF464; pfam04327 931626007108 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 931626007109 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 931626007110 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 931626007111 active site 931626007112 catalytic site [active] 931626007113 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 931626007114 amino acid carrier protein; Region: agcS; TIGR00835 931626007115 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 931626007116 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 931626007117 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 931626007118 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626007119 B12 binding site [chemical binding]; other site 931626007120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626007121 FeS/SAM binding site; other site 931626007122 Phosphotransferase enzyme family; Region: APH; pfam01636 931626007123 Catalytic domain of Protein Kinases; Region: PKc; cd00180 931626007124 active site 931626007125 ATP binding site [chemical binding]; other site 931626007126 substrate binding site [chemical binding]; other site 931626007127 activation loop (A-loop); other site 931626007128 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626007129 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626007130 Walker A/P-loop; other site 931626007131 ATP binding site [chemical binding]; other site 931626007132 Q-loop/lid; other site 931626007133 ABC transporter signature motif; other site 931626007134 Walker B; other site 931626007135 D-loop; other site 931626007136 H-loop/switch region; other site 931626007137 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 931626007138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 931626007139 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 931626007140 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 931626007141 homodimer interface [polypeptide binding]; other site 931626007142 substrate-cofactor binding pocket; other site 931626007143 catalytic residue [active] 931626007144 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 931626007145 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 931626007146 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 931626007147 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 931626007148 dimerization interface [polypeptide binding]; other site 931626007149 PAS domain; Region: PAS; smart00091 931626007150 PAS domain; Region: PAS_9; pfam13426 931626007151 PAS domain S-box; Region: sensory_box; TIGR00229 931626007152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626007153 putative active site [active] 931626007154 heme pocket [chemical binding]; other site 931626007155 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626007156 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626007157 metal binding site [ion binding]; metal-binding site 931626007158 active site 931626007159 I-site; other site 931626007160 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 931626007161 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 931626007162 Transcriptional regulators [Transcription]; Region: MarR; COG1846 931626007163 MarR family; Region: MarR_2; pfam12802 931626007164 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931626007165 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 931626007166 Flagellin N-methylase; Region: FliB; pfam03692 931626007167 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 931626007168 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 931626007169 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 931626007170 dimer interface [polypeptide binding]; other site 931626007171 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 931626007172 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 931626007173 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 931626007174 EAL domain; Region: EAL; pfam00563 931626007175 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 931626007176 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 931626007177 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626007178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 931626007179 Hemerythrin; Region: Hemerythrin; cd12107 931626007180 Fe binding site [ion binding]; other site 931626007181 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 931626007182 active pocket/dimerization site; other site 931626007183 active site 931626007184 phosphorylation site [posttranslational modification] 931626007185 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 931626007186 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 931626007187 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 931626007188 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 931626007189 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 931626007190 substrate binding site [chemical binding]; other site 931626007191 active site 931626007192 catalytic residues [active] 931626007193 heterodimer interface [polypeptide binding]; other site 931626007194 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 931626007195 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 931626007196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626007197 catalytic residue [active] 931626007198 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 931626007199 active site 931626007200 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 931626007201 active site 931626007202 ribulose/triose binding site [chemical binding]; other site 931626007203 phosphate binding site [ion binding]; other site 931626007204 substrate (anthranilate) binding pocket [chemical binding]; other site 931626007205 product (indole) binding pocket [chemical binding]; other site 931626007206 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 931626007207 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 931626007208 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 931626007209 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 931626007210 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 931626007211 glutamine binding [chemical binding]; other site 931626007212 catalytic triad [active] 931626007213 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 931626007214 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 931626007215 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 931626007216 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 931626007217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626007218 Coenzyme A binding pocket [chemical binding]; other site 931626007219 Cache domain; Region: Cache_1; pfam02743 931626007220 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931626007221 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626007222 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626007223 dimer interface [polypeptide binding]; other site 931626007224 putative CheW interface [polypeptide binding]; other site 931626007225 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 931626007226 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 931626007227 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 931626007228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626007229 active site 931626007230 phosphorylation site [posttranslational modification] 931626007231 intermolecular recognition site; other site 931626007232 dimerization interface [polypeptide binding]; other site 931626007233 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 931626007234 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 931626007235 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 931626007236 DEAD-like helicases superfamily; Region: DEXDc; smart00487 931626007237 ATP binding site [chemical binding]; other site 931626007238 Mg++ binding site [ion binding]; other site 931626007239 motif III; other site 931626007240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931626007241 nucleotide binding region [chemical binding]; other site 931626007242 ATP-binding site [chemical binding]; other site 931626007243 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 931626007244 DNA-binding site [nucleotide binding]; DNA binding site 931626007245 RNA-binding motif; other site 931626007246 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 931626007247 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 931626007248 ATP binding site [chemical binding]; other site 931626007249 substrate binding site [chemical binding]; other site 931626007250 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 931626007251 TraX protein; Region: TraX; cl05434 931626007252 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 931626007253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931626007254 ATP binding site [chemical binding]; other site 931626007255 putative Mg++ binding site [ion binding]; other site 931626007256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931626007257 nucleotide binding region [chemical binding]; other site 931626007258 ATP-binding site [chemical binding]; other site 931626007259 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 931626007260 HRDC domain; Region: HRDC; pfam00570 931626007261 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 931626007262 catalytic motif [active] 931626007263 Zn binding site [ion binding]; other site 931626007264 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626007265 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626007266 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 931626007267 dimerization interface [polypeptide binding]; other site 931626007268 substrate binding pocket [chemical binding]; other site 931626007269 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931626007270 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931626007271 active site 931626007272 FMN binding site [chemical binding]; other site 931626007273 substrate binding site [chemical binding]; other site 931626007274 putative catalytic residue [active] 931626007275 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626007276 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 931626007277 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 931626007278 ligand binding site [chemical binding]; other site 931626007279 flexible hinge region; other site 931626007280 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 931626007281 Predicted permease; Region: DUF318; cl17795 931626007282 Predicted permease; Region: DUF318; cl17795 931626007283 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 931626007284 Maf-like protein; Region: Maf; pfam02545 931626007285 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 931626007286 active site 931626007287 dimer interface [polypeptide binding]; other site 931626007288 MraW methylase family; Region: Methyltransf_5; cl17771 931626007289 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 931626007290 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931626007291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626007292 Coenzyme A binding pocket [chemical binding]; other site 931626007293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626007294 Coenzyme A binding pocket [chemical binding]; other site 931626007295 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626007296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626007297 metal binding site [ion binding]; metal-binding site 931626007298 active site 931626007299 I-site; other site 931626007300 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626007301 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 931626007302 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 931626007303 active site residues [active] 931626007304 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 931626007305 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 931626007306 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 931626007307 active site turn [active] 931626007308 phosphorylation site [posttranslational modification] 931626007309 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 931626007310 HPr interaction site; other site 931626007311 glycerol kinase (GK) interaction site [polypeptide binding]; other site 931626007312 active site 931626007313 phosphorylation site [posttranslational modification] 931626007314 CAT RNA binding domain; Region: CAT_RBD; smart01061 931626007315 transcriptional antiterminator BglG; Provisional; Region: PRK09772 931626007316 PRD domain; Region: PRD; pfam00874 931626007317 PRD domain; Region: PRD; pfam00874 931626007318 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 931626007319 Flavodoxin domain; Region: Flavodoxin_5; cl17428 931626007320 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626007321 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626007322 Predicted transcriptional regulators [Transcription]; Region: COG1695 931626007323 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 931626007324 Predicted transcriptional regulators [Transcription]; Region: COG1725 931626007325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626007326 DNA-binding site [nucleotide binding]; DNA binding site 931626007327 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626007328 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626007329 Walker A/P-loop; other site 931626007330 ATP binding site [chemical binding]; other site 931626007331 Q-loop/lid; other site 931626007332 ABC transporter signature motif; other site 931626007333 Walker B; other site 931626007334 D-loop; other site 931626007335 H-loop/switch region; other site 931626007336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626007337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626007338 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 931626007339 putative metal binding site [ion binding]; other site 931626007340 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 931626007341 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 931626007342 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626007343 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626007344 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626007345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626007346 metal binding site [ion binding]; metal-binding site 931626007347 active site 931626007348 I-site; other site 931626007349 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626007350 Zn2+ binding site [ion binding]; other site 931626007351 Mg2+ binding site [ion binding]; other site 931626007352 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626007353 Zn2+ binding site [ion binding]; other site 931626007354 Mg2+ binding site [ion binding]; other site 931626007355 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 931626007356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626007357 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626007358 ABC transporter; Region: ABC_tran_2; pfam12848 931626007359 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 931626007360 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 931626007361 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626007362 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 931626007363 Chain length determinant protein; Region: Wzz; cl15801 931626007364 Transcriptional regulator [Transcription]; Region: LytR; COG1316 931626007365 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 931626007366 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 931626007367 NAD(P) binding site [chemical binding]; other site 931626007368 homodimer interface [polypeptide binding]; other site 931626007369 substrate binding site [chemical binding]; other site 931626007370 active site 931626007371 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 931626007372 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931626007373 active site 931626007374 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 931626007375 phosphodiesterase; Provisional; Region: PRK12704 931626007376 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 931626007377 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 931626007378 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 931626007379 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 931626007380 putative NAD(P) binding site [chemical binding]; other site 931626007381 active site 931626007382 putative substrate binding site [chemical binding]; other site 931626007383 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 931626007384 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 931626007385 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 931626007386 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 931626007387 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931626007388 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 931626007389 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 931626007390 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931626007391 inhibitor-cofactor binding pocket; inhibition site 931626007392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626007393 catalytic residue [active] 931626007394 WxcM-like, C-terminal; Region: FdtA; pfam05523 931626007395 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 931626007396 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 931626007397 trimer interface [polypeptide binding]; other site 931626007398 active site 931626007399 substrate binding site [chemical binding]; other site 931626007400 CoA binding site [chemical binding]; other site 931626007401 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 931626007402 putative ligand binding site [chemical binding]; other site 931626007403 putative catalytic site [active] 931626007404 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 931626007405 putative ligand binding site [chemical binding]; other site 931626007406 putative catalytic site [active] 931626007407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931626007408 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 931626007409 putative ADP-binding pocket [chemical binding]; other site 931626007410 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 931626007411 putative ADP-binding pocket [chemical binding]; other site 931626007412 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 931626007413 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 931626007414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931626007415 NAD(P) binding site [chemical binding]; other site 931626007416 active site 931626007417 Bacterial sugar transferase; Region: Bac_transf; pfam02397 931626007418 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 931626007419 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 931626007420 Right handed beta helix region; Region: Beta_helix; pfam13229 931626007421 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 931626007422 metal binding site [ion binding]; metal-binding site 931626007423 hypothetical protein; Reviewed; Region: PRK12497 931626007424 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 931626007425 RNA/DNA hybrid binding site [nucleotide binding]; other site 931626007426 active site 931626007427 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 931626007428 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 931626007429 GTP/Mg2+ binding site [chemical binding]; other site 931626007430 G4 box; other site 931626007431 G5 box; other site 931626007432 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 931626007433 G1 box; other site 931626007434 Switch I region; other site 931626007435 G2 box; other site 931626007436 G3 box; other site 931626007437 Switch II region; other site 931626007438 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 931626007439 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 931626007440 Catalytic site [active] 931626007441 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 931626007442 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 931626007443 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 931626007444 RimM N-terminal domain; Region: RimM; pfam01782 931626007445 PRC-barrel domain; Region: PRC; pfam05239 931626007446 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 931626007447 hypothetical protein; Provisional; Region: PRK00468 931626007448 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 931626007449 signal recognition particle protein; Provisional; Region: PRK10867 931626007450 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 931626007451 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 931626007452 P loop; other site 931626007453 GTP binding site [chemical binding]; other site 931626007454 Signal peptide binding domain; Region: SRP_SPB; pfam02978 931626007455 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 931626007456 putative DNA-binding protein; Validated; Region: PRK00118 931626007457 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 931626007458 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 931626007459 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626007460 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 931626007461 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 931626007462 Walker A/P-loop; other site 931626007463 ATP binding site [chemical binding]; other site 931626007464 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 931626007465 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 931626007466 Q-loop/lid; other site 931626007467 ABC transporter signature motif; other site 931626007468 Walker B; other site 931626007469 D-loop; other site 931626007470 H-loop/switch region; other site 931626007471 ribonuclease III; Reviewed; Region: rnc; PRK00102 931626007472 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 931626007473 dimerization interface [polypeptide binding]; other site 931626007474 active site 931626007475 metal binding site [ion binding]; metal-binding site 931626007476 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 931626007477 dsRNA binding site [nucleotide binding]; other site 931626007478 acyl carrier protein; Provisional; Region: acpP; PRK00982 931626007479 putative phosphate acyltransferase; Provisional; Region: PRK05331 931626007480 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 931626007481 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 931626007482 propionate/acetate kinase; Provisional; Region: PRK12379 931626007483 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 931626007484 hypothetical protein; Provisional; Region: PRK13670 931626007485 Carboxylesterase family; Region: COesterase; pfam00135 931626007486 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 931626007487 substrate binding pocket [chemical binding]; other site 931626007488 catalytic triad [active] 931626007489 CheW-like domain; Region: CheW; pfam01584 931626007490 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 931626007491 iron-sulfur cluster [ion binding]; other site 931626007492 [2Fe-2S] cluster binding site [ion binding]; other site 931626007493 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 931626007494 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 931626007495 [2Fe-2S] cluster binding site [ion binding]; other site 931626007496 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 931626007497 hydrophobic ligand binding site; other site 931626007498 Predicted secreted protein [Function unknown]; Region: COG4086 931626007499 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 931626007500 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 931626007501 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 931626007502 CoA-binding site [chemical binding]; other site 931626007503 ATP-binding [chemical binding]; other site 931626007504 DNA polymerase I; Provisional; Region: PRK05755 931626007505 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 931626007506 active site 931626007507 putative 5' ssDNA interaction site; other site 931626007508 metal binding site 3; metal-binding site 931626007509 metal binding site 1 [ion binding]; metal-binding site 931626007510 metal binding site 2 [ion binding]; metal-binding site 931626007511 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 931626007512 putative DNA binding site [nucleotide binding]; other site 931626007513 putative metal binding site [ion binding]; other site 931626007514 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 931626007515 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 931626007516 active site 931626007517 DNA binding site [nucleotide binding] 931626007518 catalytic site [active] 931626007519 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 931626007520 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 931626007521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626007522 dimer interface [polypeptide binding]; other site 931626007523 conserved gate region; other site 931626007524 putative PBP binding loops; other site 931626007525 ABC-ATPase subunit interface; other site 931626007526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626007527 dimer interface [polypeptide binding]; other site 931626007528 conserved gate region; other site 931626007529 putative PBP binding loops; other site 931626007530 ABC-ATPase subunit interface; other site 931626007531 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 931626007532 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 931626007533 Walker A/P-loop; other site 931626007534 ATP binding site [chemical binding]; other site 931626007535 Q-loop/lid; other site 931626007536 ABC transporter signature motif; other site 931626007537 Walker B; other site 931626007538 D-loop; other site 931626007539 H-loop/switch region; other site 931626007540 FOG: CBS domain [General function prediction only]; Region: COG0517 931626007541 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 931626007542 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 931626007543 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931626007544 catalytic loop [active] 931626007545 iron binding site [ion binding]; other site 931626007546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626007547 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626007548 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 931626007549 molybdopterin cofactor binding site; other site 931626007550 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 931626007551 dimer interface [polypeptide binding]; other site 931626007552 [2Fe-2S] cluster binding site [ion binding]; other site 931626007553 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 931626007554 SLBB domain; Region: SLBB; pfam10531 931626007555 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 931626007556 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626007557 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 931626007558 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 931626007559 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 931626007560 putative dimer interface [polypeptide binding]; other site 931626007561 [2Fe-2S] cluster binding site [ion binding]; other site 931626007562 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 931626007563 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 931626007564 putative valine binding site [chemical binding]; other site 931626007565 dimer interface [polypeptide binding]; other site 931626007566 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 931626007567 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 931626007568 dimer interface [polypeptide binding]; other site 931626007569 PYR/PP interface [polypeptide binding]; other site 931626007570 TPP binding site [chemical binding]; other site 931626007571 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 931626007572 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 931626007573 TPP-binding site [chemical binding]; other site 931626007574 Uncharacterized conserved protein [Function unknown]; Region: COG2006 931626007575 Domain of unknown function (DUF362); Region: DUF362; pfam04015 931626007576 4Fe-4S binding domain; Region: Fer4; pfam00037 931626007577 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 931626007578 4Fe-4S binding domain; Region: Fer4; pfam00037 931626007579 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 931626007580 S1 domain; Region: S1_2; pfam13509 931626007581 S1 domain; Region: S1_2; pfam13509 931626007582 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 931626007583 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 931626007584 active site 931626007585 (T/H)XGH motif; other site 931626007586 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 931626007587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626007588 S-adenosylmethionine binding site [chemical binding]; other site 931626007589 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 931626007590 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 931626007591 ssDNA binding site; other site 931626007592 generic binding surface II; other site 931626007593 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931626007594 ATP binding site [chemical binding]; other site 931626007595 putative Mg++ binding site [ion binding]; other site 931626007596 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931626007597 nucleotide binding region [chemical binding]; other site 931626007598 ATP-binding site [chemical binding]; other site 931626007599 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 931626007600 DAK2 domain; Region: Dak2; pfam02734 931626007601 Asp23 family; Region: Asp23; pfam03780 931626007602 Thiamine pyrophosphokinase; Region: TPK; cd07995 931626007603 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 931626007604 active site 931626007605 dimerization interface [polypeptide binding]; other site 931626007606 thiamine binding site [chemical binding]; other site 931626007607 GTPase RsgA; Reviewed; Region: PRK00098 931626007608 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 931626007609 RNA binding site [nucleotide binding]; other site 931626007610 homodimer interface [polypeptide binding]; other site 931626007611 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 931626007612 GTPase/Zn-binding domain interface [polypeptide binding]; other site 931626007613 GTP/Mg2+ binding site [chemical binding]; other site 931626007614 G4 box; other site 931626007615 G5 box; other site 931626007616 G1 box; other site 931626007617 Switch I region; other site 931626007618 G2 box; other site 931626007619 G3 box; other site 931626007620 Switch II region; other site 931626007621 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 931626007622 Catalytic domain of Protein Kinases; Region: PKc; cd00180 931626007623 active site 931626007624 ATP binding site [chemical binding]; other site 931626007625 substrate binding site [chemical binding]; other site 931626007626 activation loop (A-loop); other site 931626007627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 931626007628 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 931626007629 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 931626007630 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 931626007631 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 931626007632 active site 931626007633 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 931626007634 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626007635 FeS/SAM binding site; other site 931626007636 16S rRNA methyltransferase B; Provisional; Region: PRK14902 931626007637 NusB family; Region: NusB; pfam01029 931626007638 putative RNA binding site [nucleotide binding]; other site 931626007639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626007640 S-adenosylmethionine binding site [chemical binding]; other site 931626007641 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 931626007642 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 931626007643 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 931626007644 putative active site [active] 931626007645 substrate binding site [chemical binding]; other site 931626007646 putative cosubstrate binding site; other site 931626007647 catalytic site [active] 931626007648 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 931626007649 substrate binding site [chemical binding]; other site 931626007650 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 931626007651 active site 931626007652 catalytic residues [active] 931626007653 metal binding site [ion binding]; metal-binding site 931626007654 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 931626007655 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 931626007656 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 931626007657 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 931626007658 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 931626007659 catalytic site [active] 931626007660 G-X2-G-X-G-K; other site 931626007661 hypothetical protein; Provisional; Region: PRK11820 931626007662 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 931626007663 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 931626007664 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 931626007665 Domain of unknown function (DUF814); Region: DUF814; pfam05670 931626007666 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 931626007667 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931626007668 RNA binding surface [nucleotide binding]; other site 931626007669 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 931626007670 active site 931626007671 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 931626007672 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931626007673 RNA binding surface [nucleotide binding]; other site 931626007674 Protein of unknown function (DUF552); Region: DUF552; pfam04472 931626007675 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 931626007676 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 931626007677 catalytic residue [active] 931626007678 HlyD family secretion protein; Region: HlyD_2; pfam12700 931626007679 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 931626007680 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 931626007681 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 931626007682 dimer interface [polypeptide binding]; other site 931626007683 anticodon binding site; other site 931626007684 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 931626007685 homodimer interface [polypeptide binding]; other site 931626007686 motif 1; other site 931626007687 active site 931626007688 motif 2; other site 931626007689 GAD domain; Region: GAD; pfam02938 931626007690 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 931626007691 motif 3; other site 931626007692 coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994 931626007693 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626007694 FeS/SAM binding site; other site 931626007695 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 931626007696 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 931626007697 dimerization interface [polypeptide binding]; other site 931626007698 putative tRNAtyr binding site [nucleotide binding]; other site 931626007699 putative active site [active] 931626007700 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 931626007701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626007702 Zn2+ binding site [ion binding]; other site 931626007703 Mg2+ binding site [ion binding]; other site 931626007704 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 931626007705 synthetase active site [active] 931626007706 NTP binding site [chemical binding]; other site 931626007707 metal binding site [ion binding]; metal-binding site 931626007708 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 931626007709 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 931626007710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931626007711 active site 931626007712 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 931626007713 DHH family; Region: DHH; pfam01368 931626007714 DHHA1 domain; Region: DHHA1; pfam02272 931626007715 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 931626007716 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 931626007717 Protein export membrane protein; Region: SecD_SecF; pfam02355 931626007718 protein-export membrane protein SecD; Region: secD; TIGR01129 931626007719 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 931626007720 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 931626007721 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 931626007722 active site 931626007723 HIGH motif; other site 931626007724 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 931626007725 active site 931626007726 KMSKS motif; other site 931626007727 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 931626007728 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 931626007729 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 931626007730 G1 box; other site 931626007731 GTP/Mg2+ binding site [chemical binding]; other site 931626007732 Switch I region; other site 931626007733 G2 box; other site 931626007734 G3 box; other site 931626007735 Switch II region; other site 931626007736 G4 box; other site 931626007737 G5 box; other site 931626007738 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 931626007739 Found in ATP-dependent protease La (LON); Region: LON; smart00464 931626007740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626007741 Walker A motif; other site 931626007742 ATP binding site [chemical binding]; other site 931626007743 Walker B motif; other site 931626007744 arginine finger; other site 931626007745 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 931626007746 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 931626007747 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 931626007748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626007749 Walker A motif; other site 931626007750 ATP binding site [chemical binding]; other site 931626007751 Walker B motif; other site 931626007752 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 931626007753 Clp protease; Region: CLP_protease; pfam00574 931626007754 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 931626007755 oligomer interface [polypeptide binding]; other site 931626007756 active site residues [active] 931626007757 trigger factor; Provisional; Region: tig; PRK01490 931626007758 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 931626007759 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 931626007760 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 931626007761 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 931626007762 Walker A/P-loop; other site 931626007763 ATP binding site [chemical binding]; other site 931626007764 Q-loop/lid; other site 931626007765 ABC transporter signature motif; other site 931626007766 Walker B; other site 931626007767 D-loop; other site 931626007768 H-loop/switch region; other site 931626007769 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 931626007770 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 931626007771 Walker A/P-loop; other site 931626007772 ATP binding site [chemical binding]; other site 931626007773 Q-loop/lid; other site 931626007774 ABC transporter signature motif; other site 931626007775 Walker B; other site 931626007776 D-loop; other site 931626007777 H-loop/switch region; other site 931626007778 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 931626007779 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 931626007780 TM-ABC transporter signature motif; other site 931626007781 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 931626007782 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931626007783 TM-ABC transporter signature motif; other site 931626007784 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 931626007785 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 931626007786 putative ligand binding site [chemical binding]; other site 931626007787 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 931626007788 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 931626007789 minor groove reading motif; other site 931626007790 helix-hairpin-helix signature motif; other site 931626007791 substrate binding pocket [chemical binding]; other site 931626007792 active site 931626007793 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 931626007794 Transglycosylase; Region: Transgly; pfam00912 931626007795 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 931626007796 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 931626007797 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 931626007798 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931626007799 RNA binding surface [nucleotide binding]; other site 931626007800 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 931626007801 active site 931626007802 hypothetical protein; Reviewed; Region: PRK00024 931626007803 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 931626007804 MPN+ (JAMM) motif; other site 931626007805 Zinc-binding site [ion binding]; other site 931626007806 Putative Fe-S cluster; Region: FeS; cl17515 931626007807 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626007808 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 931626007809 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626007810 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626007811 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626007812 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626007813 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 931626007814 electron transport complex RsxE subunit; Provisional; Region: PRK12405 931626007815 FMN-binding domain; Region: FMN_bind; cl01081 931626007816 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 931626007817 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 931626007818 SLBB domain; Region: SLBB; pfam10531 931626007819 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 931626007820 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 931626007821 oligomer interface [polypeptide binding]; other site 931626007822 putative active site [active] 931626007823 metal binding site [ion binding]; metal-binding site 931626007824 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 931626007825 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 931626007826 Aluminium resistance protein; Region: Alum_res; pfam06838 931626007827 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 931626007828 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 931626007829 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 931626007830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626007831 ATP binding site [chemical binding]; other site 931626007832 Mg2+ binding site [ion binding]; other site 931626007833 G-X-G motif; other site 931626007834 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 931626007835 ATP binding site [chemical binding]; other site 931626007836 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 931626007837 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 931626007838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626007839 Walker A motif; other site 931626007840 ATP binding site [chemical binding]; other site 931626007841 Walker B motif; other site 931626007842 arginine finger; other site 931626007843 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 931626007844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626007845 MarR family; Region: MarR_2; pfam12802 931626007846 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 931626007847 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 931626007848 Putative motility protein; Region: YjfB_motility; pfam14070 931626007849 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 931626007850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626007851 motif II; other site 931626007852 PAS domain; Region: PAS_9; pfam13426 931626007853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626007854 putative active site [active] 931626007855 heme pocket [chemical binding]; other site 931626007856 PAS fold; Region: PAS_3; pfam08447 931626007857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 931626007858 putative active site [active] 931626007859 heme pocket [chemical binding]; other site 931626007860 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626007861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626007862 metal binding site [ion binding]; metal-binding site 931626007863 active site 931626007864 I-site; other site 931626007865 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 931626007866 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 931626007867 dimer interface [polypeptide binding]; other site 931626007868 motif 1; other site 931626007869 active site 931626007870 motif 2; other site 931626007871 motif 3; other site 931626007872 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 931626007873 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 931626007874 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 931626007875 histidinol dehydrogenase; Region: hisD; TIGR00069 931626007876 NAD binding site [chemical binding]; other site 931626007877 dimerization interface [polypeptide binding]; other site 931626007878 product binding site; other site 931626007879 substrate binding site [chemical binding]; other site 931626007880 zinc binding site [ion binding]; other site 931626007881 catalytic residues [active] 931626007882 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 931626007883 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626007884 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626007885 homodimer interface [polypeptide binding]; other site 931626007886 catalytic residue [active] 931626007887 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 931626007888 putative active site pocket [active] 931626007889 4-fold oligomerization interface [polypeptide binding]; other site 931626007890 metal binding residues [ion binding]; metal-binding site 931626007891 3-fold/trimer interface [polypeptide binding]; other site 931626007892 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 931626007893 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 931626007894 putative active site [active] 931626007895 oxyanion strand; other site 931626007896 catalytic triad [active] 931626007897 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 931626007898 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 931626007899 catalytic residues [active] 931626007900 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 931626007901 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 931626007902 substrate binding site [chemical binding]; other site 931626007903 glutamase interaction surface [polypeptide binding]; other site 931626007904 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 931626007905 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 931626007906 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 931626007907 metal binding site [ion binding]; metal-binding site 931626007908 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 931626007909 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931626007910 inhibitor-cofactor binding pocket; inhibition site 931626007911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626007912 catalytic residue [active] 931626007913 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 931626007914 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 931626007915 Walker A/P-loop; other site 931626007916 ATP binding site [chemical binding]; other site 931626007917 Q-loop/lid; other site 931626007918 ABC transporter signature motif; other site 931626007919 Walker B; other site 931626007920 D-loop; other site 931626007921 H-loop/switch region; other site 931626007922 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 931626007923 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626007924 substrate binding pocket [chemical binding]; other site 931626007925 membrane-bound complex binding site; other site 931626007926 hinge residues; other site 931626007927 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 931626007928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626007929 dimer interface [polypeptide binding]; other site 931626007930 conserved gate region; other site 931626007931 putative PBP binding loops; other site 931626007932 ABC-ATPase subunit interface; other site 931626007933 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 931626007934 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626007935 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 931626007936 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 931626007937 active site residue [active] 931626007938 Sulphur transport; Region: Sulf_transp; pfam04143 931626007939 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 931626007940 active site residue [active] 931626007941 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 931626007942 active site residue [active] 931626007943 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 931626007944 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626007945 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 931626007946 Walker A/P-loop; other site 931626007947 ATP binding site [chemical binding]; other site 931626007948 Q-loop/lid; other site 931626007949 ABC transporter signature motif; other site 931626007950 Walker B; other site 931626007951 D-loop; other site 931626007952 H-loop/switch region; other site 931626007953 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 931626007954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626007955 putative PBP binding loops; other site 931626007956 dimer interface [polypeptide binding]; other site 931626007957 ABC-ATPase subunit interface; other site 931626007958 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 931626007959 NMT1-like family; Region: NMT1_2; pfam13379 931626007960 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 931626007961 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 931626007962 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 931626007963 Ligand binding site; other site 931626007964 Putative Catalytic site; other site 931626007965 DXD motif; other site 931626007966 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 931626007967 CPxP motif; other site 931626007968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626007969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626007970 LysR substrate binding domain; Region: LysR_substrate; pfam03466 931626007971 dimerization interface [polypeptide binding]; other site 931626007972 Sulphur transport; Region: Sulf_transp; pfam04143 931626007973 Sulphur transport; Region: Sulf_transp; pfam04143 931626007974 DGC domain; Region: DGC; cl01742 931626007975 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 931626007976 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 931626007977 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 931626007978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626007979 putative substrate translocation pore; other site 931626007980 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931626007981 putative DNA binding site [nucleotide binding]; other site 931626007982 putative Zn2+ binding site [ion binding]; other site 931626007983 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 931626007984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931626007985 dimerization interface [polypeptide binding]; other site 931626007986 putative DNA binding site [nucleotide binding]; other site 931626007987 putative Zn2+ binding site [ion binding]; other site 931626007988 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 931626007989 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 931626007990 XdhC Rossmann domain; Region: XdhC_C; pfam13478 931626007991 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 931626007992 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 931626007993 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626007994 catalytic residue [active] 931626007995 Putative Fe-S cluster; Region: FeS; cl17515 931626007996 DGC domain; Region: DGC; cl01742 931626007997 DGC domain; Region: DGC; cl01742 931626007998 DGC domain; Region: DGC; cl01742 931626007999 glycine cleavage system protein H; Provisional; Region: PRK13380 931626008000 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 931626008001 lipoyl attachment site [posttranslational modification]; other site 931626008002 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626008003 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626008004 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 931626008005 potential frameshift: common BLAST hit: gi|310826266|ref|YP_003958623.1| glutamate/cysteine ligase 931626008006 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 931626008007 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931626008008 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 931626008009 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 931626008010 putative deacylase active site [active] 931626008011 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 931626008012 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 931626008013 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 931626008014 dimerization interface [polypeptide binding]; other site 931626008015 domain crossover interface; other site 931626008016 redox-dependent activation switch; other site 931626008017 4-alpha-glucanotransferase; Provisional; Region: PRK14508 931626008018 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 931626008019 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 931626008020 putative ligand binding site [chemical binding]; other site 931626008021 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931626008022 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 931626008023 TM-ABC transporter signature motif; other site 931626008024 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 931626008025 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 931626008026 TM-ABC transporter signature motif; other site 931626008027 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 931626008028 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 931626008029 Walker A/P-loop; other site 931626008030 ATP binding site [chemical binding]; other site 931626008031 Q-loop/lid; other site 931626008032 ABC transporter signature motif; other site 931626008033 Walker B; other site 931626008034 D-loop; other site 931626008035 H-loop/switch region; other site 931626008036 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 931626008037 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 931626008038 Walker A/P-loop; other site 931626008039 ATP binding site [chemical binding]; other site 931626008040 Q-loop/lid; other site 931626008041 ABC transporter signature motif; other site 931626008042 Walker B; other site 931626008043 D-loop; other site 931626008044 H-loop/switch region; other site 931626008045 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 931626008046 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 931626008047 polyphosphate kinase; Provisional; Region: PRK05443 931626008048 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 931626008049 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 931626008050 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 931626008051 putative domain interface [polypeptide binding]; other site 931626008052 putative active site [active] 931626008053 catalytic site [active] 931626008054 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 931626008055 putative domain interface [polypeptide binding]; other site 931626008056 putative active site [active] 931626008057 catalytic site [active] 931626008058 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 931626008059 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 931626008060 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 931626008061 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 931626008062 substrate binding pocket [chemical binding]; other site 931626008063 dimer interface [polypeptide binding]; other site 931626008064 inhibitor binding site; inhibition site 931626008065 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626008066 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626008067 B12 binding site [chemical binding]; other site 931626008068 Methanol-cobalamin methyltransferase B subunit; Region: MtaB; pfam12176 931626008069 B12 binding domain; Region: B12-binding_2; cl03653 931626008070 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626008071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626008072 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626008073 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626008074 B12 binding site [chemical binding]; other site 931626008075 cobalt ligand [ion binding]; other site 931626008076 Sensory domain found in PocR; Region: PocR; pfam10114 931626008077 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 931626008078 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931626008079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626008080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626008081 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 931626008082 Rubredoxin; Region: Rubredoxin; pfam00301 931626008083 iron binding site [ion binding]; other site 931626008084 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 931626008085 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931626008086 nucleotide binding site [chemical binding]; other site 931626008087 Yip1 domain; Region: Yip1; pfam04893 931626008088 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626008089 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 931626008090 FtsX-like permease family; Region: FtsX; pfam02687 931626008091 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 931626008092 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626008093 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626008094 Walker A/P-loop; other site 931626008095 ATP binding site [chemical binding]; other site 931626008096 Q-loop/lid; other site 931626008097 ABC transporter signature motif; other site 931626008098 Walker B; other site 931626008099 D-loop; other site 931626008100 H-loop/switch region; other site 931626008101 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 931626008102 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626008103 Walker A/P-loop; other site 931626008104 ATP binding site [chemical binding]; other site 931626008105 Q-loop/lid; other site 931626008106 ABC transporter signature motif; other site 931626008107 Walker B; other site 931626008108 D-loop; other site 931626008109 H-loop/switch region; other site 931626008110 Predicted transcriptional regulators [Transcription]; Region: COG1725 931626008111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626008112 DNA-binding site [nucleotide binding]; DNA binding site 931626008113 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931626008114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626008115 dimerization interface [polypeptide binding]; other site 931626008116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626008117 dimer interface [polypeptide binding]; other site 931626008118 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931626008119 putative CheW interface [polypeptide binding]; other site 931626008120 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 931626008121 ABC1 family; Region: ABC1; cl17513 931626008122 Uncharacterized conserved protein [Function unknown]; Region: COG3937 931626008123 threonine dehydratase; Provisional; Region: PRK08198 931626008124 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 931626008125 tetramer interface [polypeptide binding]; other site 931626008126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626008127 catalytic residue [active] 931626008128 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 931626008129 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626008130 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626008131 SCP-2 sterol transfer family; Region: SCP2; pfam02036 931626008132 Uncharacterized conserved protein [Function unknown]; Region: COG2006 931626008133 Domain of unknown function (DUF362); Region: DUF362; pfam04015 931626008134 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 931626008135 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626008136 putative active site [active] 931626008137 heme pocket [chemical binding]; other site 931626008138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626008139 Walker A motif; other site 931626008140 ATP binding site [chemical binding]; other site 931626008141 Walker B motif; other site 931626008142 arginine finger; other site 931626008143 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931626008144 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 931626008145 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 931626008146 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 931626008147 E3 interaction surface; other site 931626008148 lipoyl attachment site [posttranslational modification]; other site 931626008149 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 931626008150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931626008151 NAD(P) binding site [chemical binding]; other site 931626008152 active site 931626008153 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931626008154 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 931626008155 acyl-activating enzyme (AAE) consensus motif; other site 931626008156 AMP binding site [chemical binding]; other site 931626008157 active site 931626008158 CoA binding site [chemical binding]; other site 931626008159 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 931626008160 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 931626008161 AIR carboxylase; Region: AIRC; smart01001 931626008162 Protein of unknown function DUF111; Region: DUF111; pfam01969 931626008163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931626008164 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 931626008165 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931626008166 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626008167 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626008168 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626008169 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 931626008170 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 931626008171 catalytic triad [active] 931626008172 XdhC Rossmann domain; Region: XdhC_C; pfam13478 931626008173 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 931626008174 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 931626008175 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 931626008176 active site 931626008177 putative substrate binding pocket [chemical binding]; other site 931626008178 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 931626008179 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931626008180 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931626008181 active site 931626008182 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 931626008183 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626008184 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 931626008185 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 931626008186 FtsX-like permease family; Region: FtsX; pfam02687 931626008187 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931626008188 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626008189 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931626008190 FtsX-like permease family; Region: FtsX; pfam02687 931626008191 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626008192 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626008193 Walker A/P-loop; other site 931626008194 ATP binding site [chemical binding]; other site 931626008195 Q-loop/lid; other site 931626008196 ABC transporter signature motif; other site 931626008197 Walker B; other site 931626008198 D-loop; other site 931626008199 H-loop/switch region; other site 931626008200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626008201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626008202 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 931626008203 CHAP domain; Region: CHAP; pfam05257 931626008204 Surface antigen [General function prediction only]; Region: COG3942 931626008205 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 931626008206 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626008207 Clostridial hydrophobic W; Region: ChW; pfam07538 931626008208 Clostridial hydrophobic W; Region: ChW; pfam07538 931626008209 Clostridial hydrophobic W; Region: ChW; pfam07538 931626008210 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 931626008211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626008212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626008213 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 931626008214 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626008215 Walker A/P-loop; other site 931626008216 ATP binding site [chemical binding]; other site 931626008217 Q-loop/lid; other site 931626008218 ABC transporter signature motif; other site 931626008219 Walker B; other site 931626008220 D-loop; other site 931626008221 H-loop/switch region; other site 931626008222 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931626008223 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 931626008224 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 931626008225 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931626008226 DNA binding residues [nucleotide binding] 931626008227 drug binding residues [chemical binding]; other site 931626008228 dimer interface [polypeptide binding]; other site 931626008229 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931626008230 EcsC protein family; Region: EcsC; pfam12787 931626008231 CmuC_like. Proteins similar to the putative corrinoid methyltransferase CmuC. Its function has been inferred from sequence similarity to the methyltransferases CmuA and MtaA. Mutants of Methylobacterium sp. disrupted in cmuC and purU appear deficient in...; Region: CmuC_like; cd03309 931626008232 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626008233 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626008234 B12 binding site [chemical binding]; other site 931626008235 cobalt ligand [ion binding]; other site 931626008236 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 931626008237 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 931626008238 substrate binding pocket [chemical binding]; other site 931626008239 dimer interface [polypeptide binding]; other site 931626008240 inhibitor binding site; inhibition site 931626008241 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 931626008242 intersubunit interface [polypeptide binding]; other site 931626008243 active site 931626008244 zinc binding site [ion binding]; other site 931626008245 Na+ binding site [ion binding]; other site 931626008246 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 931626008247 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 931626008248 active site 931626008249 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 931626008250 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 931626008251 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931626008252 PYR/PP interface [polypeptide binding]; other site 931626008253 dimer interface [polypeptide binding]; other site 931626008254 TPP binding site [chemical binding]; other site 931626008255 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931626008256 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 931626008257 TPP-binding site [chemical binding]; other site 931626008258 dimer interface [polypeptide binding]; other site 931626008259 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 931626008260 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 931626008261 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 931626008262 PYR/PP interface [polypeptide binding]; other site 931626008263 dimer interface [polypeptide binding]; other site 931626008264 TPP binding site [chemical binding]; other site 931626008265 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931626008266 transketolase; Reviewed; Region: PRK05899 931626008267 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 931626008268 TPP-binding site [chemical binding]; other site 931626008269 dimer interface [polypeptide binding]; other site 931626008270 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 931626008271 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 931626008272 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931626008273 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 931626008274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931626008275 nucleotide binding site [chemical binding]; other site 931626008276 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 931626008277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931626008278 NAD(P) binding site [chemical binding]; other site 931626008279 active site 931626008280 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 931626008281 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 931626008282 classical (c) SDRs; Region: SDR_c; cd05233 931626008283 NAD(P) binding site [chemical binding]; other site 931626008284 active site 931626008285 glycerol kinase; Provisional; Region: glpK; PRK00047 931626008286 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 931626008287 N- and C-terminal domain interface [polypeptide binding]; other site 931626008288 active site 931626008289 MgATP binding site [chemical binding]; other site 931626008290 catalytic site [active] 931626008291 metal binding site [ion binding]; metal-binding site 931626008292 glycerol binding site [chemical binding]; other site 931626008293 homotetramer interface [polypeptide binding]; other site 931626008294 homodimer interface [polypeptide binding]; other site 931626008295 FBP binding site [chemical binding]; other site 931626008296 protein IIAGlc interface [polypeptide binding]; other site 931626008297 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 931626008298 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 931626008299 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 931626008300 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 931626008301 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626008302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626008303 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 931626008304 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 931626008305 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 931626008306 E3 interaction surface; other site 931626008307 lipoyl attachment site [posttranslational modification]; other site 931626008308 e3 binding domain; Region: E3_binding; pfam02817 931626008309 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 931626008310 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 931626008311 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 931626008312 alpha subunit interface [polypeptide binding]; other site 931626008313 TPP binding site [chemical binding]; other site 931626008314 heterodimer interface [polypeptide binding]; other site 931626008315 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931626008316 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 931626008317 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 931626008318 tetramer interface [polypeptide binding]; other site 931626008319 TPP-binding site [chemical binding]; other site 931626008320 heterodimer interface [polypeptide binding]; other site 931626008321 phosphorylation loop region [posttranslational modification] 931626008322 Class I aldolases; Region: Aldolase_Class_I; cl17187 931626008323 catalytic residue [active] 931626008324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 931626008325 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 931626008326 nucleotide binding site [chemical binding]; other site 931626008327 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 931626008328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626008329 I-site; other site 931626008330 active site 931626008331 metal binding site [ion binding]; metal-binding site 931626008332 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626008333 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 931626008334 active site 931626008335 catalytic residues [active] 931626008336 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 931626008337 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626008338 Clostridial hydrophobic W; Region: ChW; pfam07538 931626008339 Clostridial hydrophobic W; Region: ChW; pfam07538 931626008340 Clostridial hydrophobic W; Region: ChW; pfam07538 931626008341 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 931626008342 putative deacylase active site [active] 931626008343 E3 Ubiquitin ligase; Region: GIDE; pfam12483 931626008344 phage shock protein A; Region: phageshock_pspA; TIGR02977 931626008345 Cache domain; Region: Cache_1; pfam02743 931626008346 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626008347 dimerization interface [polypeptide binding]; other site 931626008348 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626008349 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626008350 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626008351 dimer interface [polypeptide binding]; other site 931626008352 putative CheW interface [polypeptide binding]; other site 931626008353 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931626008354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626008355 dimerization interface [polypeptide binding]; other site 931626008356 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626008357 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626008358 dimer interface [polypeptide binding]; other site 931626008359 putative CheW interface [polypeptide binding]; other site 931626008360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626008361 Coenzyme A binding pocket [chemical binding]; other site 931626008362 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 931626008363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626008364 heme pocket [chemical binding]; other site 931626008365 putative active site [active] 931626008366 PAS domain S-box; Region: sensory_box; TIGR00229 931626008367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626008368 putative active site [active] 931626008369 heme pocket [chemical binding]; other site 931626008370 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626008371 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626008372 metal binding site [ion binding]; metal-binding site 931626008373 active site 931626008374 I-site; other site 931626008375 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626008376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626008377 active site 931626008378 phosphorylation site [posttranslational modification] 931626008379 intermolecular recognition site; other site 931626008380 dimerization interface [polypeptide binding]; other site 931626008381 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 931626008382 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 931626008383 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 931626008384 PhoU domain; Region: PhoU; pfam01895 931626008385 PhoU domain; Region: PhoU; pfam01895 931626008386 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 931626008387 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 931626008388 Walker A/P-loop; other site 931626008389 ATP binding site [chemical binding]; other site 931626008390 Q-loop/lid; other site 931626008391 ABC transporter signature motif; other site 931626008392 Walker B; other site 931626008393 D-loop; other site 931626008394 H-loop/switch region; other site 931626008395 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 931626008396 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 931626008397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626008398 dimer interface [polypeptide binding]; other site 931626008399 conserved gate region; other site 931626008400 putative PBP binding loops; other site 931626008401 ABC-ATPase subunit interface; other site 931626008402 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 931626008403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626008404 dimer interface [polypeptide binding]; other site 931626008405 conserved gate region; other site 931626008406 putative PBP binding loops; other site 931626008407 ABC-ATPase subunit interface; other site 931626008408 PBP superfamily domain; Region: PBP_like_2; cl17296 931626008409 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 931626008410 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 931626008411 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626008412 Zn2+ binding site [ion binding]; other site 931626008413 Mg2+ binding site [ion binding]; other site 931626008414 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 931626008415 nudix motif; other site 931626008416 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 931626008417 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 931626008418 ATP binding site [chemical binding]; other site 931626008419 Mg++ binding site [ion binding]; other site 931626008420 motif III; other site 931626008421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931626008422 nucleotide binding region [chemical binding]; other site 931626008423 ATP-binding site [chemical binding]; other site 931626008424 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 931626008425 RNA binding site [nucleotide binding]; other site 931626008426 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 931626008427 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 931626008428 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626008429 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626008430 B12 binding site [chemical binding]; other site 931626008431 Sensory domain found in PocR; Region: PocR; pfam10114 931626008432 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 931626008433 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931626008434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626008435 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626008436 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 931626008437 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626008438 B12 binding site [chemical binding]; other site 931626008439 cobalt ligand [ion binding]; other site 931626008440 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 931626008441 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 931626008442 substrate binding pocket [chemical binding]; other site 931626008443 dimer interface [polypeptide binding]; other site 931626008444 inhibitor binding site; inhibition site 931626008445 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626008446 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 931626008447 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 931626008448 glutaminase active site [active] 931626008449 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 931626008450 dimer interface [polypeptide binding]; other site 931626008451 active site 931626008452 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 931626008453 dimer interface [polypeptide binding]; other site 931626008454 active site 931626008455 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 931626008456 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 931626008457 active site 931626008458 substrate binding site [chemical binding]; other site 931626008459 metal binding site [ion binding]; metal-binding site 931626008460 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 931626008461 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 931626008462 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 931626008463 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931626008464 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 931626008465 Ion channel; Region: Ion_trans_2; pfam07885 931626008466 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 931626008467 GIY-YIG motif/motif A; other site 931626008468 putative active site [active] 931626008469 putative metal binding site [ion binding]; other site 931626008470 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 931626008471 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 931626008472 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 931626008473 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931626008474 active site 931626008475 HIGH motif; other site 931626008476 nucleotide binding site [chemical binding]; other site 931626008477 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 931626008478 active site 931626008479 KMSKS motif; other site 931626008480 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 931626008481 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931626008482 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 931626008483 acyl-activating enzyme (AAE) consensus motif; other site 931626008484 AMP binding site [chemical binding]; other site 931626008485 active site 931626008486 CoA binding site [chemical binding]; other site 931626008487 ACT domain-containing protein [General function prediction only]; Region: COG4747 931626008488 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 931626008489 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 931626008490 ATP synthase subunit D; Region: ATP-synt_D; pfam01813 931626008491 V-type ATP synthase subunit B; Provisional; Region: PRK04196 931626008492 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 931626008493 Walker A motif homologous position; other site 931626008494 Walker B motif; other site 931626008495 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 931626008496 V-type ATP synthase subunit A; Provisional; Region: PRK04192 931626008497 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 931626008498 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 931626008499 Walker A motif/ATP binding site; other site 931626008500 Walker B motif; other site 931626008501 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 931626008502 V-type ATP synthase subunit E; Provisional; Region: PRK01558 931626008503 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 931626008504 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 931626008505 V-type ATP synthase subunit I; Validated; Region: PRK05771 931626008506 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 931626008507 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 931626008508 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 931626008509 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 931626008510 metal-binding site [ion binding] 931626008511 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931626008512 Soluble P-type ATPase [General function prediction only]; Region: COG4087 931626008513 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 931626008514 metal-binding site [ion binding] 931626008515 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 931626008516 putative homodimer interface [polypeptide binding]; other site 931626008517 putative homotetramer interface [polypeptide binding]; other site 931626008518 putative allosteric switch controlling residues; other site 931626008519 putative metal binding site [ion binding]; other site 931626008520 putative homodimer-homodimer interface [polypeptide binding]; other site 931626008521 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931626008522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626008523 S-adenosylmethionine binding site [chemical binding]; other site 931626008524 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 931626008525 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 931626008526 metal binding site [ion binding]; metal-binding site 931626008527 dimer interface [polypeptide binding]; other site 931626008528 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 931626008529 ApbE family; Region: ApbE; pfam02424 931626008530 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 931626008531 trimer interface [polypeptide binding]; other site 931626008532 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 931626008533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 931626008534 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626008535 dimerization interface [polypeptide binding]; other site 931626008536 PAS domain; Region: PAS; smart00091 931626008537 putative active site [active] 931626008538 heme pocket [chemical binding]; other site 931626008539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626008540 dimer interface [polypeptide binding]; other site 931626008541 phosphorylation site [posttranslational modification] 931626008542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626008543 ATP binding site [chemical binding]; other site 931626008544 Mg2+ binding site [ion binding]; other site 931626008545 G-X-G motif; other site 931626008546 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626008547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626008548 active site 931626008549 phosphorylation site [posttranslational modification] 931626008550 intermolecular recognition site; other site 931626008551 dimerization interface [polypeptide binding]; other site 931626008552 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626008553 DNA binding site [nucleotide binding] 931626008554 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931626008555 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 931626008556 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 931626008557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 931626008558 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 931626008559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 931626008560 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 931626008561 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 931626008562 putative N- and C-terminal domain interface [polypeptide binding]; other site 931626008563 putative active site [active] 931626008564 MgATP binding site [chemical binding]; other site 931626008565 catalytic site [active] 931626008566 metal binding site [ion binding]; metal-binding site 931626008567 putative carbohydrate binding site [chemical binding]; other site 931626008568 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 931626008569 hypothetical protein; Provisional; Region: PRK02399 931626008570 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 931626008571 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 931626008572 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 931626008573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626008574 Walker A motif; other site 931626008575 ATP binding site [chemical binding]; other site 931626008576 Walker B motif; other site 931626008577 arginine finger; other site 931626008578 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931626008579 Uncharacterized conserved protein [Function unknown]; Region: COG0327 931626008580 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 931626008581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 931626008582 Uncharacterized conserved protein [Function unknown]; Region: COG0327 931626008583 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 931626008584 Family of unknown function (DUF633); Region: DUF633; pfam04816 931626008585 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 931626008586 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 931626008587 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 931626008588 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931626008589 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 931626008590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931626008591 DNA binding residues [nucleotide binding] 931626008592 DNA primase; Validated; Region: dnaG; PRK05667 931626008593 CHC2 zinc finger; Region: zf-CHC2; pfam01807 931626008594 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 931626008595 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 931626008596 active site 931626008597 metal binding site [ion binding]; metal-binding site 931626008598 interdomain interaction site; other site 931626008599 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 931626008600 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 931626008601 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 931626008602 dimer interface [polypeptide binding]; other site 931626008603 PYR/PP interface [polypeptide binding]; other site 931626008604 TPP binding site [chemical binding]; other site 931626008605 substrate binding site [chemical binding]; other site 931626008606 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 931626008607 Domain of unknown function; Region: EKR; pfam10371 931626008608 4Fe-4S binding domain; Region: Fer4_6; pfam12837 931626008609 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626008610 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 931626008611 TPP-binding site [chemical binding]; other site 931626008612 dimer interface [polypeptide binding]; other site 931626008613 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 931626008614 amino acid carrier protein; Region: agcS; TIGR00835 931626008615 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 931626008616 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 931626008617 hexamer interface [polypeptide binding]; other site 931626008618 ligand binding site [chemical binding]; other site 931626008619 putative active site [active] 931626008620 NAD(P) binding site [chemical binding]; other site 931626008621 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 931626008622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931626008623 putative DNA binding site [nucleotide binding]; other site 931626008624 putative Zn2+ binding site [ion binding]; other site 931626008625 AsnC family; Region: AsnC_trans_reg; pfam01037 931626008626 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 931626008627 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 931626008628 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 931626008629 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 931626008630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626008631 Zn2+ binding site [ion binding]; other site 931626008632 Mg2+ binding site [ion binding]; other site 931626008633 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626008634 metal binding site [ion binding]; metal-binding site 931626008635 active site 931626008636 I-site; other site 931626008637 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626008638 putative transporter; Provisional; Region: PRK10484 931626008639 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 931626008640 Na binding site [ion binding]; other site 931626008641 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 931626008642 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 931626008643 active site 931626008644 dimer interface [polypeptide binding]; other site 931626008645 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 931626008646 dimer interface [polypeptide binding]; other site 931626008647 active site 931626008648 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 931626008649 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931626008650 active site 931626008651 catalytic tetrad [active] 931626008652 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626008653 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 931626008654 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 931626008655 dimer interface [polypeptide binding]; other site 931626008656 active site 931626008657 metal binding site [ion binding]; metal-binding site 931626008658 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 931626008659 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931626008660 inhibitor-cofactor binding pocket; inhibition site 931626008661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626008662 catalytic residue [active] 931626008663 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 931626008664 Clp amino terminal domain; Region: Clp_N; pfam02861 931626008665 Clp amino terminal domain; Region: Clp_N; pfam02861 931626008666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626008667 Walker A motif; other site 931626008668 ATP binding site [chemical binding]; other site 931626008669 Walker B motif; other site 931626008670 arginine finger; other site 931626008671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626008672 Walker A motif; other site 931626008673 ATP binding site [chemical binding]; other site 931626008674 Walker B motif; other site 931626008675 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 931626008676 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 931626008677 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 931626008678 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 931626008679 phosphoglyceromutase; Provisional; Region: PRK05434 931626008680 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 931626008681 triosephosphate isomerase; Provisional; Region: PRK14565 931626008682 substrate binding site [chemical binding]; other site 931626008683 dimer interface [polypeptide binding]; other site 931626008684 catalytic triad [active] 931626008685 Phosphoglycerate kinase; Region: PGK; pfam00162 931626008686 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 931626008687 substrate binding site [chemical binding]; other site 931626008688 hinge regions; other site 931626008689 ADP binding site [chemical binding]; other site 931626008690 catalytic site [active] 931626008691 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 931626008692 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 931626008693 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 931626008694 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 931626008695 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 931626008696 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 931626008697 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 931626008698 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 931626008699 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 931626008700 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 931626008701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626008702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626008703 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 931626008704 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 931626008705 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 931626008706 Walker A motif/ATP binding site; other site 931626008707 Walker B motif; other site 931626008708 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 931626008709 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 931626008710 Flagellar assembly protein FliH; Region: FliH; pfam02108 931626008711 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 931626008712 FliG C-terminal domain; Region: FliG_C; pfam01706 931626008713 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 931626008714 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 931626008715 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 931626008716 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 931626008717 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 931626008718 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 931626008719 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 931626008720 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 931626008721 Flagellar protein FliT; Region: FliT; pfam05400 931626008722 Flagellar protein FliS; Region: FliS; cl00654 931626008723 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 931626008724 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 931626008725 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 931626008726 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 931626008727 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 931626008728 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 931626008729 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 931626008730 putative binding surface; other site 931626008731 active site 931626008732 P2 response regulator binding domain; Region: P2; pfam07194 931626008733 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 931626008734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626008735 ATP binding site [chemical binding]; other site 931626008736 Mg2+ binding site [ion binding]; other site 931626008737 G-X-G motif; other site 931626008738 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 931626008739 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 931626008740 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931626008741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 931626008742 Transposase; Region: DDE_Tnp_ISL3; pfam01610 931626008743 Methyltransferase domain; Region: Methyltransf_24; pfam13578 931626008744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626008745 FeS/SAM binding site; other site 931626008746 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 931626008747 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 931626008748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626008749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 931626008750 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 931626008751 NAD(P) binding site [chemical binding]; other site 931626008752 active site 931626008753 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 931626008754 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931626008755 inhibitor-cofactor binding pocket; inhibition site 931626008756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626008757 catalytic residue [active] 931626008758 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 931626008759 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 931626008760 substrate binding site; other site 931626008761 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 931626008762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 931626008763 active site 931626008764 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 931626008765 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626008766 FeS/SAM binding site; other site 931626008767 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 931626008768 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 931626008769 ligand binding site; other site 931626008770 tetramer interface; other site 931626008771 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 931626008772 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 931626008773 active site 931626008774 homodimer interface [polypeptide binding]; other site 931626008775 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 931626008776 NeuB family; Region: NeuB; pfam03102 931626008777 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 931626008778 NeuB binding interface [polypeptide binding]; other site 931626008779 putative substrate binding site [chemical binding]; other site 931626008780 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 931626008781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931626008782 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 931626008783 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931626008784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626008785 catalytic residue [active] 931626008786 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 931626008787 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931626008788 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 931626008789 active site 931626008790 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 931626008791 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 931626008792 NAD binding site [chemical binding]; other site 931626008793 substrate binding site [chemical binding]; other site 931626008794 active site 931626008795 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 931626008796 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 931626008797 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 931626008798 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 931626008799 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 931626008800 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 931626008801 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 931626008802 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 931626008803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626008804 active site 931626008805 phosphorylation site [posttranslational modification] 931626008806 intermolecular recognition site; other site 931626008807 dimerization interface [polypeptide binding]; other site 931626008808 CheB methylesterase; Region: CheB_methylest; pfam01339 931626008809 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 931626008810 putative CheA interaction surface; other site 931626008811 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 931626008812 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 931626008813 CheC-like family; Region: CheC; pfam04509 931626008814 Protein of unknown function (DUF342); Region: DUF342; pfam03961 931626008815 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 931626008816 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 931626008817 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 931626008818 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 931626008819 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 931626008820 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 931626008821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931626008822 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 931626008823 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931626008824 DNA binding residues [nucleotide binding] 931626008825 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 931626008826 FHIPEP family; Region: FHIPEP; pfam00771 931626008827 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 931626008828 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 931626008829 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 931626008830 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 931626008831 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 931626008832 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 931626008833 Response regulator receiver domain; Region: Response_reg; pfam00072 931626008834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626008835 active site 931626008836 phosphorylation site [posttranslational modification] 931626008837 intermolecular recognition site; other site 931626008838 dimerization interface [polypeptide binding]; other site 931626008839 CheC-like family; Region: CheC; pfam04509 931626008840 flagellar motor switch protein FliN; Region: fliN; TIGR02480 931626008841 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 931626008842 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 931626008843 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 931626008844 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 931626008845 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 931626008846 ligand binding site [chemical binding]; other site 931626008847 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 931626008848 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 931626008849 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 931626008850 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 931626008851 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 931626008852 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 931626008853 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 931626008854 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 931626008855 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 931626008856 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 931626008857 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 931626008858 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 931626008859 PhoU domain; Region: PhoU; pfam01895 931626008860 PhoU domain; Region: PhoU; pfam01895 931626008861 glycyl-tRNA synthetase; Provisional; Region: PRK04173 931626008862 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 931626008863 motif 1; other site 931626008864 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 931626008865 active site 931626008866 motif 2; other site 931626008867 motif 3; other site 931626008868 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 931626008869 anticodon binding site; other site 931626008870 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626008871 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626008872 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626008873 peptide chain release factor 1; Validated; Region: prfA; PRK00591 931626008874 This domain is found in peptide chain release factors; Region: PCRF; smart00937 931626008875 RF-1 domain; Region: RF-1; pfam00472 931626008876 EDD domain protein, DegV family; Region: DegV; TIGR00762 931626008877 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 931626008878 putative hydrolase; Validated; Region: PRK09248 931626008879 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 931626008880 active site 931626008881 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 931626008882 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 931626008883 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 931626008884 Hpr binding site; other site 931626008885 active site 931626008886 homohexamer subunit interaction site [polypeptide binding]; other site 931626008887 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 931626008888 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 931626008889 GIY-YIG motif/motif A; other site 931626008890 active site 931626008891 catalytic site [active] 931626008892 putative DNA binding site [nucleotide binding]; other site 931626008893 metal binding site [ion binding]; metal-binding site 931626008894 UvrB/uvrC motif; Region: UVR; pfam02151 931626008895 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 931626008896 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 931626008897 DNA-binding site [nucleotide binding]; DNA binding site 931626008898 RNA-binding motif; other site 931626008899 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 931626008900 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 931626008901 G1 box; other site 931626008902 GTP/Mg2+ binding site [chemical binding]; other site 931626008903 Switch I region; other site 931626008904 G2 box; other site 931626008905 G3 box; other site 931626008906 Switch II region; other site 931626008907 G4 box; other site 931626008908 G5 box; other site 931626008909 Nucleoside recognition; Region: Gate; pfam07670 931626008910 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 931626008911 Nucleoside recognition; Region: Gate; pfam07670 931626008912 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 931626008913 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 931626008914 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 931626008915 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 931626008916 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 931626008917 excinuclease ABC subunit B; Provisional; Region: PRK05298 931626008918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931626008919 ATP binding site [chemical binding]; other site 931626008920 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931626008921 nucleotide binding region [chemical binding]; other site 931626008922 ATP-binding site [chemical binding]; other site 931626008923 Ultra-violet resistance protein B; Region: UvrB; pfam12344 931626008924 UvrB/uvrC motif; Region: UVR; pfam02151 931626008925 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 931626008926 C-terminal peptidase (prc); Region: prc; TIGR00225 931626008927 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 931626008928 protein binding site [polypeptide binding]; other site 931626008929 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 931626008930 Catalytic dyad [active] 931626008931 Coiled-coil receptor-binding R-domain of colicin E2; Region: E2R135; pfam11570 931626008932 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 931626008933 Peptidase family M23; Region: Peptidase_M23; pfam01551 931626008934 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 931626008935 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 931626008936 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 931626008937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626008938 Walker A/P-loop; other site 931626008939 ATP binding site [chemical binding]; other site 931626008940 Q-loop/lid; other site 931626008941 ABC transporter signature motif; other site 931626008942 Walker B; other site 931626008943 D-loop; other site 931626008944 H-loop/switch region; other site 931626008945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 931626008946 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 931626008947 Peptidase family M23; Region: Peptidase_M23; pfam01551 931626008948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626008949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931626008950 putative substrate translocation pore; other site 931626008951 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 931626008952 dimer interface [polypeptide binding]; other site 931626008953 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 931626008954 active site 931626008955 metal binding site [ion binding]; metal-binding site 931626008956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626008957 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931626008958 putative substrate translocation pore; other site 931626008959 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626008960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626008961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626008962 DNA polymerase III PolC; Validated; Region: polC; PRK00448 931626008963 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 931626008964 generic binding surface II; other site 931626008965 generic binding surface I; other site 931626008966 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 931626008967 active site 931626008968 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 931626008969 active site 931626008970 catalytic site [active] 931626008971 substrate binding site [chemical binding]; other site 931626008972 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 931626008973 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 931626008974 GcpE protein; Region: GcpE; pfam04551 931626008975 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 931626008976 Peptidase family M50; Region: Peptidase_M50; pfam02163 931626008977 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 931626008978 active site 931626008979 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 931626008980 putative substrate binding region [chemical binding]; other site 931626008981 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 931626008982 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 931626008983 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 931626008984 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 931626008985 catalytic residue [active] 931626008986 putative FPP diphosphate binding site; other site 931626008987 putative FPP binding hydrophobic cleft; other site 931626008988 dimer interface [polypeptide binding]; other site 931626008989 putative IPP diphosphate binding site; other site 931626008990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 931626008991 YheO-like PAS domain; Region: PAS_6; pfam08348 931626008992 HTH domain; Region: HTH_22; pfam13309 931626008993 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 931626008994 homotrimer interaction site [polypeptide binding]; other site 931626008995 putative active site [active] 931626008996 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 931626008997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 931626008998 active site 931626008999 motif I; other site 931626009000 motif II; other site 931626009001 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626009002 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626009003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626009004 Walker A/P-loop; other site 931626009005 ATP binding site [chemical binding]; other site 931626009006 Q-loop/lid; other site 931626009007 ABC transporter signature motif; other site 931626009008 Walker B; other site 931626009009 D-loop; other site 931626009010 H-loop/switch region; other site 931626009011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626009012 dimer interface [polypeptide binding]; other site 931626009013 conserved gate region; other site 931626009014 putative PBP binding loops; other site 931626009015 ABC-ATPase subunit interface; other site 931626009016 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 931626009017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 931626009018 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 931626009019 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 931626009020 active site 931626009021 catalytic residues [active] 931626009022 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626009023 Bacterial Ig-like domain 2; Region: BID_2; smart00635 931626009024 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626009025 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626009026 Clostridial hydrophobic W; Region: ChW; pfam07538 931626009027 Clostridial hydrophobic W; Region: ChW; pfam07538 931626009028 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626009029 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931626009030 FtsX-like permease family; Region: FtsX; pfam02687 931626009031 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626009032 FtsX-like permease family; Region: FtsX; pfam02687 931626009033 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 931626009034 Part of AAA domain; Region: AAA_19; pfam13245 931626009035 Family description; Region: UvrD_C_2; pfam13538 931626009036 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 931626009037 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 931626009038 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 931626009039 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 931626009040 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 931626009041 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 931626009042 active site 931626009043 HIGH motif; other site 931626009044 dimer interface [polypeptide binding]; other site 931626009045 KMSKS motif; other site 931626009046 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 931626009047 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931626009048 active site 931626009049 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 931626009050 elongation factor G; Reviewed; Region: PRK12740 931626009051 G1 box; other site 931626009052 putative GEF interaction site [polypeptide binding]; other site 931626009053 GTP/Mg2+ binding site [chemical binding]; other site 931626009054 Switch I region; other site 931626009055 G2 box; other site 931626009056 G3 box; other site 931626009057 Switch II region; other site 931626009058 G4 box; other site 931626009059 G5 box; other site 931626009060 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 931626009061 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 931626009062 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 931626009063 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 931626009064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931626009065 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 931626009066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931626009067 DNA binding residues [nucleotide binding] 931626009068 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 931626009069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626009070 ATP binding site [chemical binding]; other site 931626009071 Mg2+ binding site [ion binding]; other site 931626009072 G-X-G motif; other site 931626009073 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 931626009074 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 931626009075 anti sigma factor interaction site; other site 931626009076 regulatory phosphorylation site [posttranslational modification]; other site 931626009077 YtxH-like protein; Region: YtxH; pfam12732 931626009078 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 931626009079 dimerization domain swap beta strand [polypeptide binding]; other site 931626009080 regulatory protein interface [polypeptide binding]; other site 931626009081 active site 931626009082 regulatory phosphorylation site [posttranslational modification]; other site 931626009083 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 931626009084 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 931626009085 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 931626009086 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 931626009087 recombination protein RecR; Reviewed; Region: recR; PRK00076 931626009088 RecR protein; Region: RecR; pfam02132 931626009089 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 931626009090 putative active site [active] 931626009091 putative metal-binding site [ion binding]; other site 931626009092 tetramer interface [polypeptide binding]; other site 931626009093 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 931626009094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626009095 Walker A motif; other site 931626009096 ATP binding site [chemical binding]; other site 931626009097 DNA polymerase III subunit delta'; Validated; Region: PRK08485 931626009098 Walker B motif; other site 931626009099 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 931626009100 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 931626009101 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 931626009102 putative hexamer interface [polypeptide binding]; other site 931626009103 putative hexagonal pore; other site 931626009104 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 931626009105 putative hexamer interface [polypeptide binding]; other site 931626009106 putative hexagonal pore; other site 931626009107 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 931626009108 SLBB domain; Region: SLBB; pfam10531 931626009109 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 931626009110 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 931626009111 putative catalytic cysteine [active] 931626009112 Domain of unknown function (DUF336); Region: DUF336; pfam03928 931626009113 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 931626009114 Domain of unknown function (DUF336); Region: DUF336; pfam03928 931626009115 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 931626009116 Hexamer/Pentamer interface [polypeptide binding]; other site 931626009117 central pore; other site 931626009118 Flavoprotein; Region: Flavoprotein; cl08021 931626009119 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 931626009120 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 931626009121 nucleotide binding site [chemical binding]; other site 931626009122 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 931626009123 Propanediol utilisation protein PduL; Region: PduL; pfam06130 931626009124 Propanediol utilisation protein PduL; Region: PduL; pfam06130 931626009125 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 931626009126 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 931626009127 Hexamer interface [polypeptide binding]; other site 931626009128 Hexagonal pore residue; other site 931626009129 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 931626009130 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 931626009131 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 931626009132 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 931626009133 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 931626009134 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 931626009135 propanediol dehydratase large subunit; Provisional; Region: pduC; PRK15444 931626009136 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 931626009137 alpha-beta subunit interface [polypeptide binding]; other site 931626009138 alpha-gamma subunit interface [polypeptide binding]; other site 931626009139 active site 931626009140 substrate and K+ binding site; other site 931626009141 K+ binding site [ion binding]; other site 931626009142 cobalamin binding site [chemical binding]; other site 931626009143 propanediol utilization protein PduB; Provisional; Region: PRK15415 931626009144 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 931626009145 putative hexamer interface [polypeptide binding]; other site 931626009146 putative hexagonal pore; other site 931626009147 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 931626009148 putative hexamer interface [polypeptide binding]; other site 931626009149 putative hexagonal pore; other site 931626009150 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 931626009151 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 931626009152 Hexamer interface [polypeptide binding]; other site 931626009153 Hexagonal pore residue; other site 931626009154 Response regulator receiver domain; Region: Response_reg; pfam00072 931626009155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626009156 active site 931626009157 phosphorylation site [posttranslational modification] 931626009158 intermolecular recognition site; other site 931626009159 dimerization interface [polypeptide binding]; other site 931626009160 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626009161 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626009162 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 931626009163 Sensory domain found in PocR; Region: PocR; pfam10114 931626009164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626009165 Histidine kinase; Region: His_kinase; pfam06580 931626009166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626009167 ATP binding site [chemical binding]; other site 931626009168 Mg2+ binding site [ion binding]; other site 931626009169 G-X-G motif; other site 931626009170 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 931626009171 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 931626009172 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 931626009173 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626009174 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626009175 metal binding site [ion binding]; metal-binding site 931626009176 active site 931626009177 I-site; other site 931626009178 stage V sporulation protein K; Region: spore_V_K; TIGR02881 931626009179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626009180 Walker A motif; other site 931626009181 ATP binding site [chemical binding]; other site 931626009182 Walker B motif; other site 931626009183 arginine finger; other site 931626009184 stage V sporulation protein K; Region: spore_V_K; TIGR02881 931626009185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626009186 Walker A motif; other site 931626009187 ATP binding site [chemical binding]; other site 931626009188 Walker B motif; other site 931626009189 arginine finger; other site 931626009190 stage V sporulation protein K; Region: spore_V_K; TIGR02881 931626009191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626009192 Walker A motif; other site 931626009193 ATP binding site [chemical binding]; other site 931626009194 Walker B motif; other site 931626009195 arginine finger; other site 931626009196 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 931626009197 putative active site [active] 931626009198 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 931626009199 putative active site [active] 931626009200 putative metal binding site [ion binding]; other site 931626009201 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 931626009202 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 931626009203 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931626009204 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 931626009205 ATP-grasp domain; Region: ATP-grasp_4; cl17255 931626009206 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626009207 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626009208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626009209 Walker A/P-loop; other site 931626009210 ATP binding site [chemical binding]; other site 931626009211 Q-loop/lid; other site 931626009212 ABC transporter signature motif; other site 931626009213 Walker B; other site 931626009214 D-loop; other site 931626009215 H-loop/switch region; other site 931626009216 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 931626009217 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626009218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626009219 Walker A/P-loop; other site 931626009220 ATP binding site [chemical binding]; other site 931626009221 Q-loop/lid; other site 931626009222 ABC transporter signature motif; other site 931626009223 Walker B; other site 931626009224 D-loop; other site 931626009225 H-loop/switch region; other site 931626009226 GH3 auxin-responsive promoter; Region: GH3; pfam03321 931626009227 GH3 auxin-responsive promoter; Region: GH3; pfam03321 931626009228 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 931626009229 anti sigma factor interaction site; other site 931626009230 regulatory phosphorylation site [posttranslational modification]; other site 931626009231 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626009232 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931626009233 pyruvate carboxylase; Reviewed; Region: PRK12999 931626009234 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 931626009235 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 931626009236 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 931626009237 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 931626009238 active site 931626009239 catalytic residues [active] 931626009240 metal binding site [ion binding]; metal-binding site 931626009241 homodimer binding site [polypeptide binding]; other site 931626009242 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 931626009243 carboxyltransferase (CT) interaction site; other site 931626009244 biotinylation site [posttranslational modification]; other site 931626009245 Chorismate mutase type II; Region: CM_2; smart00830 931626009246 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 931626009247 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 931626009248 Tetramer interface [polypeptide binding]; other site 931626009249 active site 931626009250 FMN-binding site [chemical binding]; other site 931626009251 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 931626009252 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 931626009253 hinge; other site 931626009254 active site 931626009255 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 931626009256 active site 931626009257 dimer interface [polypeptide binding]; other site 931626009258 metal binding site [ion binding]; metal-binding site 931626009259 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 931626009260 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931626009261 TM-ABC transporter signature motif; other site 931626009262 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 931626009263 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 931626009264 TM-ABC transporter signature motif; other site 931626009265 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 931626009266 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 931626009267 Walker A/P-loop; other site 931626009268 ATP binding site [chemical binding]; other site 931626009269 Q-loop/lid; other site 931626009270 ABC transporter signature motif; other site 931626009271 Walker B; other site 931626009272 D-loop; other site 931626009273 H-loop/switch region; other site 931626009274 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 931626009275 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 931626009276 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 931626009277 putative ligand binding site [chemical binding]; other site 931626009278 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626009279 MarR family; Region: MarR_2; cl17246 931626009280 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 931626009281 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 931626009282 salicylate synthase Irp9; Reviewed; Region: PRK06772 931626009283 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 931626009284 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 931626009285 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 931626009286 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 931626009287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626009288 DNA-binding site [nucleotide binding]; DNA binding site 931626009289 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626009290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626009291 homodimer interface [polypeptide binding]; other site 931626009292 catalytic residue [active] 931626009293 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 931626009294 dimer interface [polypeptide binding]; other site 931626009295 pyridoxal binding site [chemical binding]; other site 931626009296 ATP binding site [chemical binding]; other site 931626009297 RecX family; Region: RecX; cl00936 931626009298 Putative amidase domain; Region: Amidase_6; pfam12671 931626009299 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 931626009300 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 931626009301 Walker A/P-loop; other site 931626009302 ATP binding site [chemical binding]; other site 931626009303 Q-loop/lid; other site 931626009304 ABC transporter signature motif; other site 931626009305 Walker B; other site 931626009306 D-loop; other site 931626009307 H-loop/switch region; other site 931626009308 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 931626009309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626009310 dimer interface [polypeptide binding]; other site 931626009311 conserved gate region; other site 931626009312 putative PBP binding loops; other site 931626009313 ABC-ATPase subunit interface; other site 931626009314 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 931626009315 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626009316 substrate binding pocket [chemical binding]; other site 931626009317 membrane-bound complex binding site; other site 931626009318 hinge residues; other site 931626009319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626009320 FeS/SAM binding site; other site 931626009321 Radical SAM superfamily; Region: Radical_SAM; pfam04055 931626009322 Transcriptional regulator PadR-like family; Region: PadR; cl17335 931626009323 Predicted transcriptional regulators [Transcription]; Region: COG1695 931626009324 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 931626009325 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931626009326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626009327 motif II; other site 931626009328 Yqey-like protein; Region: YqeY; pfam09424 931626009329 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 931626009330 nucleotide binding site/active site [active] 931626009331 HIT family signature motif; other site 931626009332 catalytic residue [active] 931626009333 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 931626009334 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 931626009335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626009336 FeS/SAM binding site; other site 931626009337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 931626009338 RNA methyltransferase, RsmE family; Region: TIGR00046 931626009339 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 931626009340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626009341 S-adenosylmethionine binding site [chemical binding]; other site 931626009342 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 931626009343 putative hexamer interface [polypeptide binding]; other site 931626009344 putative hexagonal pore; other site 931626009345 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 931626009346 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 931626009347 G1 box; other site 931626009348 GTP/Mg2+ binding site [chemical binding]; other site 931626009349 G2 box; other site 931626009350 Switch I region; other site 931626009351 G3 box; other site 931626009352 Switch II region; other site 931626009353 G4 box; other site 931626009354 G5 box; other site 931626009355 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 931626009356 Phosphotransferase enzyme family; Region: APH; pfam01636 931626009357 Transcriptional regulator; Region: Rrf2; cl17282 931626009358 Rrf2 family protein; Region: rrf2_super; TIGR00738 931626009359 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 931626009360 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 931626009361 dimer interface [polypeptide binding]; other site 931626009362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626009363 catalytic residue [active] 931626009364 chaperone protein DnaJ; Provisional; Region: PRK10767 931626009365 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 931626009366 HSP70 interaction site [polypeptide binding]; other site 931626009367 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 931626009368 substrate binding site [polypeptide binding]; other site 931626009369 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 931626009370 Zn binding sites [ion binding]; other site 931626009371 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 931626009372 dimer interface [polypeptide binding]; other site 931626009373 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 931626009374 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 931626009375 nucleotide binding site [chemical binding]; other site 931626009376 NEF interaction site [polypeptide binding]; other site 931626009377 SBD interface [polypeptide binding]; other site 931626009378 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 931626009379 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 931626009380 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 931626009381 dimer interface [polypeptide binding]; other site 931626009382 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 931626009383 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 931626009384 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 931626009385 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 931626009386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626009387 FeS/SAM binding site; other site 931626009388 HemN C-terminal domain; Region: HemN_C; pfam06969 931626009389 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 931626009390 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 931626009391 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 931626009392 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 931626009393 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 931626009394 putative catalytic cysteine [active] 931626009395 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626009396 Clostridial hydrophobic W; Region: ChW; pfam07538 931626009397 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626009398 Clostridial hydrophobic W; Region: ChW; pfam07538 931626009399 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626009400 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626009401 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626009402 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626009403 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931626009404 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626009405 triple tyrosine motif-containing protein; Provisional; Region: PRK14081 931626009406 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626009407 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626009408 Clostridial hydrophobic W; Region: ChW; pfam07538 931626009409 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626009410 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 931626009411 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 931626009412 Transposase IS200 like; Region: Y1_Tnp; pfam01797 931626009413 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 931626009414 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 931626009415 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 931626009416 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 931626009417 Transposase; Region: DDE_Tnp_ISL3; pfam01610 931626009418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 931626009419 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 931626009420 Transposase; Region: DDE_Tnp_ISL3; pfam01610 931626009421 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 931626009422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931626009423 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931626009424 DNA binding residues [nucleotide binding] 931626009425 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 931626009426 Sensory domain found in PocR; Region: PocR; pfam10114 931626009427 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931626009428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626009429 dimer interface [polypeptide binding]; other site 931626009430 putative CheW interface [polypeptide binding]; other site 931626009431 Holin family; Region: Phage_holin_4; pfam05105 931626009432 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 931626009433 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 931626009434 Peptidase M15; Region: Peptidase_M15_3; cl01194 931626009435 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 931626009436 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 931626009437 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 931626009438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931626009439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931626009440 DNA binding residues [nucleotide binding] 931626009441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 931626009442 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 931626009443 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 931626009444 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 931626009445 phosphate binding site [ion binding]; other site 931626009446 putative substrate binding pocket [chemical binding]; other site 931626009447 dimer interface [polypeptide binding]; other site 931626009448 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 931626009449 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 931626009450 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 931626009451 active site 931626009452 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 931626009453 FAD binding domain; Region: FAD_binding_4; pfam01565 931626009454 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 931626009455 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 931626009456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931626009457 active site 931626009458 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 931626009459 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 931626009460 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 931626009461 DNA binding site [nucleotide binding] 931626009462 AAA domain; Region: AAA_30; pfam13604 931626009463 Family description; Region: UvrD_C_2; pfam13538 931626009464 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931626009465 catalytic loop [active] 931626009466 iron binding site [ion binding]; other site 931626009467 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 931626009468 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 931626009469 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 931626009470 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 931626009471 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 931626009472 dimer interface [polypeptide binding]; other site 931626009473 [2Fe-2S] cluster binding site [ion binding]; other site 931626009474 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 931626009475 SLBB domain; Region: SLBB; pfam10531 931626009476 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 931626009477 4Fe-4S binding domain; Region: Fer4; pfam00037 931626009478 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626009479 4Fe-4S binding domain; Region: Fer4; pfam00037 931626009480 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 931626009481 dimer interface [polypeptide binding]; other site 931626009482 [2Fe-2S] cluster binding site [ion binding]; other site 931626009483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626009484 ATP binding site [chemical binding]; other site 931626009485 Mg2+ binding site [ion binding]; other site 931626009486 G-X-G motif; other site 931626009487 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 931626009488 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 931626009489 putative dimer interface [polypeptide binding]; other site 931626009490 [2Fe-2S] cluster binding site [ion binding]; other site 931626009491 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 931626009492 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 931626009493 active site 931626009494 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 931626009495 DRTGG domain; Region: DRTGG; pfam07085 931626009496 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 931626009497 4Fe-4S binding domain; Region: Fer4; pfam00037 931626009498 4Fe-4S binding domain; Region: Fer4_6; pfam12837 931626009499 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 931626009500 Putative Fe-S cluster; Region: FeS; cl17515 931626009501 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 931626009502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626009503 ATP binding site [chemical binding]; other site 931626009504 G-X-G motif; other site 931626009505 DRTGG domain; Region: DRTGG; pfam07085 931626009506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626009507 Walker A/P-loop; other site 931626009508 ATP binding site [chemical binding]; other site 931626009509 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 931626009510 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 931626009511 active site 931626009512 metal binding site [ion binding]; metal-binding site 931626009513 DNA binding site [nucleotide binding] 931626009514 GAF domain; Region: GAF; pfam01590 931626009515 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 931626009516 PAS domain; Region: PAS; smart00091 931626009517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626009518 Walker A motif; other site 931626009519 ATP binding site [chemical binding]; other site 931626009520 Walker B motif; other site 931626009521 arginine finger; other site 931626009522 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931626009523 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 931626009524 catalytic core [active] 931626009525 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 931626009526 metal-binding site 931626009527 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626009528 Zn2+ binding site [ion binding]; other site 931626009529 Mg2+ binding site [ion binding]; other site 931626009530 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 931626009531 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 931626009532 XdhC Rossmann domain; Region: XdhC_C; pfam13478 931626009533 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 931626009534 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 931626009535 acyl-activating enzyme (AAE) consensus motif; other site 931626009536 active site 931626009537 AMP binding site [chemical binding]; other site 931626009538 CoA binding site [chemical binding]; other site 931626009539 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626009540 Radical SAM superfamily; Region: Radical_SAM; pfam04055 931626009541 FeS/SAM binding site; other site 931626009542 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 931626009543 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931626009544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626009545 S-adenosylmethionine binding site [chemical binding]; other site 931626009546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626009547 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 931626009548 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931626009549 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 931626009550 catalytic loop [active] 931626009551 iron binding site [ion binding]; other site 931626009552 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 931626009553 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 931626009554 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 931626009555 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 931626009556 putative MPT binding site; other site 931626009557 Methyltransferase domain; Region: Methyltransf_32; pfam13679 931626009558 Methyltransferase domain; Region: Methyltransf_31; pfam13847 931626009559 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 931626009560 CrcB-like protein; Region: CRCB; cl09114 931626009561 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626009562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626009563 dimerization interface [polypeptide binding]; other site 931626009564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626009565 dimer interface [polypeptide binding]; other site 931626009566 phosphorylation site [posttranslational modification] 931626009567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626009568 ATP binding site [chemical binding]; other site 931626009569 Mg2+ binding site [ion binding]; other site 931626009570 G-X-G motif; other site 931626009571 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626009572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626009573 active site 931626009574 phosphorylation site [posttranslational modification] 931626009575 intermolecular recognition site; other site 931626009576 dimerization interface [polypeptide binding]; other site 931626009577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626009578 DNA binding site [nucleotide binding] 931626009579 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 931626009580 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 931626009581 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 931626009582 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 931626009583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626009584 Walker A/P-loop; other site 931626009585 ATP binding site [chemical binding]; other site 931626009586 Q-loop/lid; other site 931626009587 ABC transporter signature motif; other site 931626009588 Walker B; other site 931626009589 D-loop; other site 931626009590 H-loop/switch region; other site 931626009591 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 931626009592 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 931626009593 active site 931626009594 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 931626009595 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 931626009596 MFS/sugar transport protein; Region: MFS_2; pfam13347 931626009597 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 931626009598 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626009599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626009600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626009601 YCII-related domain; Region: YCII; cl00999 931626009602 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 931626009603 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 931626009604 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 931626009605 Soluble P-type ATPase [General function prediction only]; Region: COG4087 931626009606 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 931626009607 shikimate kinase; Reviewed; Region: aroK; PRK00131 931626009608 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 931626009609 ADP binding site [chemical binding]; other site 931626009610 magnesium binding site [ion binding]; other site 931626009611 putative shikimate binding site; other site 931626009612 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 931626009613 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 931626009614 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 931626009615 shikimate binding site; other site 931626009616 NAD(P) binding site [chemical binding]; other site 931626009617 uracil transporter; Provisional; Region: PRK10720 931626009618 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 931626009619 putative metal binding site [ion binding]; other site 931626009620 Uncharacterized conserved protein [Function unknown]; Region: COG1432 931626009621 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 931626009622 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 931626009623 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u1; cd12826 931626009624 Cl binding site [ion binding]; other site 931626009625 oligomer interface [polypeptide binding]; other site 931626009626 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931626009627 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 931626009628 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931626009629 active site 931626009630 FMN binding site [chemical binding]; other site 931626009631 substrate binding site [chemical binding]; other site 931626009632 putative catalytic residue [active] 931626009633 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931626009634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626009635 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 931626009636 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 931626009637 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 931626009638 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 931626009639 Walker A/P-loop; other site 931626009640 ATP binding site [chemical binding]; other site 931626009641 Q-loop/lid; other site 931626009642 ABC transporter signature motif; other site 931626009643 Walker B; other site 931626009644 D-loop; other site 931626009645 H-loop/switch region; other site 931626009646 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 931626009647 NMT1/THI5 like; Region: NMT1; pfam09084 931626009648 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 931626009649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626009650 dimer interface [polypeptide binding]; other site 931626009651 conserved gate region; other site 931626009652 putative PBP binding loops; other site 931626009653 ABC-ATPase subunit interface; other site 931626009654 Domain of unknown function DUF77; Region: DUF77; pfam01910 931626009655 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 931626009656 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 931626009657 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 931626009658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626009659 FeS/SAM binding site; other site 931626009660 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 931626009661 HTH domain; Region: HTH_11; pfam08279 931626009662 3H domain; Region: 3H; pfam02829 931626009663 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 931626009664 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 931626009665 dimerization interface [polypeptide binding]; other site 931626009666 active site 931626009667 L-aspartate oxidase; Provisional; Region: PRK06175 931626009668 FAD binding domain; Region: FAD_binding_2; pfam00890 931626009669 Quinolinate synthetase A protein; Region: NadA; pfam02445 931626009670 CHAD domain; Region: CHAD; pfam05235 931626009671 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 931626009672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626009673 Walker A/P-loop; other site 931626009674 ATP binding site [chemical binding]; other site 931626009675 Q-loop/lid; other site 931626009676 ABC transporter signature motif; other site 931626009677 Walker B; other site 931626009678 D-loop; other site 931626009679 H-loop/switch region; other site 931626009680 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 931626009681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626009682 dimer interface [polypeptide binding]; other site 931626009683 conserved gate region; other site 931626009684 putative PBP binding loops; other site 931626009685 ABC-ATPase subunit interface; other site 931626009686 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 931626009687 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 931626009688 Helix-turn-helix domain; Region: HTH_17; pfam12728 931626009689 TOBE domain; Region: TOBE; cl01440 931626009690 Helix-turn-helix domain; Region: HTH_17; pfam12728 931626009691 PBP superfamily domain; Region: PBP_like; pfam12727 931626009692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626009693 PAS domain; Region: PAS_9; pfam13426 931626009694 putative active site [active] 931626009695 heme pocket [chemical binding]; other site 931626009696 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626009697 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626009698 metal binding site [ion binding]; metal-binding site 931626009699 active site 931626009700 I-site; other site 931626009701 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626009702 FMN-binding domain; Region: FMN_bind; cl01081 931626009703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626009704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626009705 amino acid transporter; Region: 2A0306; TIGR00909 931626009706 Helix-turn-helix domain; Region: HTH_18; pfam12833 931626009707 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 931626009708 homotrimer interaction site [polypeptide binding]; other site 931626009709 putative active site [active] 931626009710 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 931626009711 hydroxyglutarate oxidase; Provisional; Region: PRK11728 931626009712 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 931626009713 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 931626009714 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931626009715 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 931626009716 NAD(P) binding pocket [chemical binding]; other site 931626009717 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 931626009718 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 931626009719 ornithine cyclodeaminase; Validated; Region: PRK06199 931626009720 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 931626009721 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 931626009722 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 931626009723 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626009724 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 931626009725 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 931626009726 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 931626009727 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931626009728 EamA-like transporter family; Region: EamA; pfam00892 931626009729 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 931626009730 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 931626009731 B12 binding site [chemical binding]; other site 931626009732 cobalt ligand [ion binding]; other site 931626009733 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 931626009734 oligomerization interface [polypeptide binding]; other site 931626009735 active site 931626009736 metal binding site [ion binding]; metal-binding site 931626009737 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 931626009738 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 931626009739 BCCT family transporter; Region: BCCT; pfam02028 931626009740 hypothetical protein; Provisional; Region: PRK07475 931626009741 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 931626009742 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 931626009743 PAS domain; Region: PAS_9; pfam13426 931626009744 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 931626009745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626009746 Walker A motif; other site 931626009747 ATP binding site [chemical binding]; other site 931626009748 Walker B motif; other site 931626009749 arginine finger; other site 931626009750 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931626009751 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 931626009752 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 931626009753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626009754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626009755 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 931626009756 Rubredoxin [Energy production and conversion]; Region: COG1773 931626009757 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 931626009758 iron binding site [ion binding]; other site 931626009759 Rubredoxin [Energy production and conversion]; Region: COG1773 931626009760 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 931626009761 iron binding site [ion binding]; other site 931626009762 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 931626009763 iron binding site [ion binding]; other site 931626009764 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 931626009765 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 931626009766 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 931626009767 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 931626009768 active site 931626009769 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 931626009770 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 931626009771 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 931626009772 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 931626009773 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 931626009774 substrate binding pocket [chemical binding]; other site 931626009775 dimer interface [polypeptide binding]; other site 931626009776 inhibitor binding site; inhibition site 931626009777 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 931626009778 B12 binding site [chemical binding]; other site 931626009779 hypothetical protein; Provisional; Region: PRK04334 931626009780 NIL domain; Region: NIL; pfam09383 931626009781 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 931626009782 4Fe-4S binding domain; Region: Fer4; cl02805 931626009783 Domain of unknown function DUF39; Region: DUF39; pfam01837 931626009784 peptide chain release factor 2; Validated; Region: prfB; PRK00578 931626009785 This domain is found in peptide chain release factors; Region: PCRF; smart00937 931626009786 RF-1 domain; Region: RF-1; pfam00472 931626009787 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 931626009788 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 931626009789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931626009790 nucleotide binding region [chemical binding]; other site 931626009791 ATP-binding site [chemical binding]; other site 931626009792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626009793 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 931626009794 30S subunit binding site; other site 931626009795 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 931626009796 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 931626009797 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 931626009798 putative active site [active] 931626009799 catalytic site [active] 931626009800 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 931626009801 putative active site [active] 931626009802 catalytic site [active] 931626009803 Predicted transcriptional regulators [Transcription]; Region: COG1695 931626009804 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 931626009805 Predicted membrane protein [Function unknown]; Region: COG4709 931626009806 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 931626009807 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 931626009808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626009809 FeS/SAM binding site; other site 931626009810 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 931626009811 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 931626009812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626009813 FeS/SAM binding site; other site 931626009814 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 931626009815 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 931626009816 Uncharacterized conserved protein [Function unknown]; Region: COG4198 931626009817 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 931626009818 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 931626009819 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 931626009820 putative ligand binding site [chemical binding]; other site 931626009821 putative NAD binding site [chemical binding]; other site 931626009822 putative catalytic site [active] 931626009823 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 931626009824 L-serine binding site [chemical binding]; other site 931626009825 ACT domain interface; other site 931626009826 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 931626009827 homodimer interface [polypeptide binding]; other site 931626009828 substrate-cofactor binding pocket; other site 931626009829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626009830 catalytic residue [active] 931626009831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 931626009832 YbbR-like protein; Region: YbbR; pfam07949 931626009833 TIGR00159 family protein; Region: TIGR00159 931626009834 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 931626009835 FOG: CBS domain [General function prediction only]; Region: COG0517 931626009836 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 931626009837 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 931626009838 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 931626009839 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 931626009840 Predicted membrane protein [Function unknown]; Region: COG4905 931626009841 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 931626009842 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 931626009843 Domain of unknown function DUF20; Region: UPF0118; pfam01594 931626009844 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 931626009845 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 931626009846 G1 box; other site 931626009847 putative GEF interaction site [polypeptide binding]; other site 931626009848 GTP/Mg2+ binding site [chemical binding]; other site 931626009849 Switch I region; other site 931626009850 G2 box; other site 931626009851 G3 box; other site 931626009852 Switch II region; other site 931626009853 G4 box; other site 931626009854 G5 box; other site 931626009855 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 931626009856 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 931626009857 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 931626009858 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 931626009859 23S rRNA interface [nucleotide binding]; other site 931626009860 L3 interface [polypeptide binding]; other site 931626009861 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 931626009862 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 931626009863 dimerization interface 3.5A [polypeptide binding]; other site 931626009864 active site 931626009865 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 931626009866 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 931626009867 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931626009868 Walker A/P-loop; other site 931626009869 ATP binding site [chemical binding]; other site 931626009870 Q-loop/lid; other site 931626009871 ABC transporter signature motif; other site 931626009872 Walker B; other site 931626009873 D-loop; other site 931626009874 H-loop/switch region; other site 931626009875 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 931626009876 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931626009877 Walker A/P-loop; other site 931626009878 ATP binding site [chemical binding]; other site 931626009879 Q-loop/lid; other site 931626009880 ABC transporter signature motif; other site 931626009881 Walker B; other site 931626009882 D-loop; other site 931626009883 H-loop/switch region; other site 931626009884 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 931626009885 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 931626009886 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 931626009887 alphaNTD - beta interaction site [polypeptide binding]; other site 931626009888 alphaNTD homodimer interface [polypeptide binding]; other site 931626009889 alphaNTD - beta' interaction site [polypeptide binding]; other site 931626009890 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 931626009891 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 931626009892 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 931626009893 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931626009894 RNA binding surface [nucleotide binding]; other site 931626009895 30S ribosomal protein S11; Validated; Region: PRK05309 931626009896 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 931626009897 30S ribosomal protein S13; Region: bact_S13; TIGR03631 931626009898 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 931626009899 rRNA binding site [nucleotide binding]; other site 931626009900 predicted 30S ribosome binding site; other site 931626009901 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 931626009902 RNA binding site [nucleotide binding]; other site 931626009903 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 931626009904 active site 931626009905 adenylate kinase; Reviewed; Region: adk; PRK00279 931626009906 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 931626009907 AMP-binding site [chemical binding]; other site 931626009908 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 931626009909 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 931626009910 SecY translocase; Region: SecY; pfam00344 931626009911 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 931626009912 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 931626009913 23S rRNA binding site [nucleotide binding]; other site 931626009914 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 931626009915 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 931626009916 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 931626009917 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 931626009918 5S rRNA interface [nucleotide binding]; other site 931626009919 23S rRNA interface [nucleotide binding]; other site 931626009920 L5 interface [polypeptide binding]; other site 931626009921 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 931626009922 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 931626009923 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 931626009924 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 931626009925 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 931626009926 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 931626009927 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 931626009928 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 931626009929 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 931626009930 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 931626009931 RNA binding site [nucleotide binding]; other site 931626009932 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 931626009933 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 931626009934 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 931626009935 23S rRNA interface [nucleotide binding]; other site 931626009936 putative translocon interaction site; other site 931626009937 signal recognition particle (SRP54) interaction site; other site 931626009938 L23 interface [polypeptide binding]; other site 931626009939 trigger factor interaction site; other site 931626009940 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 931626009941 23S rRNA interface [nucleotide binding]; other site 931626009942 5S rRNA interface [nucleotide binding]; other site 931626009943 putative antibiotic binding site [chemical binding]; other site 931626009944 L25 interface [polypeptide binding]; other site 931626009945 L27 interface [polypeptide binding]; other site 931626009946 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 931626009947 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 931626009948 G-X-X-G motif; other site 931626009949 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 931626009950 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 931626009951 protein-rRNA interface [nucleotide binding]; other site 931626009952 putative translocon binding site; other site 931626009953 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 931626009954 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 931626009955 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 931626009956 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 931626009957 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 931626009958 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 931626009959 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 931626009960 EDD domain protein, DegV family; Region: DegV; TIGR00762 931626009961 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 931626009962 elongation factor Tu; Reviewed; Region: PRK00049 931626009963 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 931626009964 G1 box; other site 931626009965 GEF interaction site [polypeptide binding]; other site 931626009966 GTP/Mg2+ binding site [chemical binding]; other site 931626009967 Switch I region; other site 931626009968 G2 box; other site 931626009969 G3 box; other site 931626009970 Switch II region; other site 931626009971 G4 box; other site 931626009972 G5 box; other site 931626009973 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 931626009974 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 931626009975 Antibiotic Binding Site [chemical binding]; other site 931626009976 RNA polymerase factor sigma-70; Validated; Region: PRK08295 931626009977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931626009978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 931626009979 DNA binding residues [nucleotide binding] 931626009980 YacP-like NYN domain; Region: NYN_YacP; pfam05991 931626009981 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 931626009982 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 931626009983 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 931626009984 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 931626009985 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 931626009986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 931626009987 histidyl-tRNA synthetase; Region: hisS; TIGR00442 931626009988 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 931626009989 dimer interface [polypeptide binding]; other site 931626009990 motif 1; other site 931626009991 active site 931626009992 motif 2; other site 931626009993 motif 3; other site 931626009994 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 931626009995 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 931626009996 active site 931626009997 HIGH motif; other site 931626009998 dimer interface [polypeptide binding]; other site 931626009999 KMSKS motif; other site 931626010000 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931626010001 RNA binding surface [nucleotide binding]; other site 931626010002 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 931626010003 Domain of unknown function DUF20; Region: UPF0118; pfam01594 931626010004 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 931626010005 Transcriptional regulators [Transcription]; Region: FadR; COG2186 931626010006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626010007 DNA-binding site [nucleotide binding]; DNA binding site 931626010008 FCD domain; Region: FCD; pfam07729 931626010009 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 931626010010 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 931626010011 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 931626010012 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 931626010013 ligand binding site [chemical binding]; other site 931626010014 active site 931626010015 UGI interface [polypeptide binding]; other site 931626010016 catalytic site [active] 931626010017 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 931626010018 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 931626010019 active site 931626010020 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 931626010021 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 931626010022 active site 931626010023 catalytic residue [active] 931626010024 dimer interface [polypeptide binding]; other site 931626010025 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 931626010026 Clostridial hydrophobic W; Region: ChW; cl02763 931626010027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626010028 non-specific DNA binding site [nucleotide binding]; other site 931626010029 salt bridge; other site 931626010030 sequence-specific DNA binding site [nucleotide binding]; other site 931626010031 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 931626010032 G1 box; other site 931626010033 GTP/Mg2+ binding site [chemical binding]; other site 931626010034 Switch I region; other site 931626010035 G3 box; other site 931626010036 Switch II region; other site 931626010037 G4 box; other site 931626010038 G5 box; other site 931626010039 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 931626010040 putative hexamer interface [polypeptide binding]; other site 931626010041 putative hexagonal pore; other site 931626010042 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626010043 dimerization interface [polypeptide binding]; other site 931626010044 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626010045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626010046 dimer interface [polypeptide binding]; other site 931626010047 putative CheW interface [polypeptide binding]; other site 931626010048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626010049 dimerization interface [polypeptide binding]; other site 931626010050 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626010051 dimer interface [polypeptide binding]; other site 931626010052 putative CheW interface [polypeptide binding]; other site 931626010053 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 931626010054 EamA-like transporter family; Region: EamA; pfam00892 931626010055 EamA-like transporter family; Region: EamA; pfam00892 931626010056 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 931626010057 putative active site [active] 931626010058 putative CoA binding site [chemical binding]; other site 931626010059 nudix motif; other site 931626010060 metal binding site [ion binding]; metal-binding site 931626010061 Predicted transcriptional regulators [Transcription]; Region: COG1695 931626010062 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 931626010063 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 931626010064 Domain of unknown function (DUF336); Region: DUF336; pfam03928 931626010065 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931626010066 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626010067 dimerization interface [polypeptide binding]; other site 931626010068 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626010069 dimer interface [polypeptide binding]; other site 931626010070 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931626010071 putative CheW interface [polypeptide binding]; other site 931626010072 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 931626010073 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931626010074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626010075 dimerization interface [polypeptide binding]; other site 931626010076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626010077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626010078 dimer interface [polypeptide binding]; other site 931626010079 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 931626010080 putative CheW interface [polypeptide binding]; other site 931626010081 Predicted transcriptional regulators [Transcription]; Region: COG1725 931626010082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626010083 DNA-binding site [nucleotide binding]; DNA binding site 931626010084 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626010085 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626010086 Walker A/P-loop; other site 931626010087 ATP binding site [chemical binding]; other site 931626010088 Q-loop/lid; other site 931626010089 ABC transporter signature motif; other site 931626010090 Walker B; other site 931626010091 D-loop; other site 931626010092 H-loop/switch region; other site 931626010093 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 931626010094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 931626010095 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 931626010096 active site 931626010097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626010098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626010099 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 931626010100 GIY-YIG motif/motif A; other site 931626010101 active site 931626010102 catalytic site [active] 931626010103 putative DNA binding site [nucleotide binding]; other site 931626010104 metal binding site [ion binding]; metal-binding site 931626010105 TOBE domain; Region: TOBE; cl01440 931626010106 TOBE domain; Region: TOBE; cl01440 931626010107 Transcriptional regulator [Transcription]; Region: LysR; COG0583 931626010108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 931626010109 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 931626010110 putative dimerization interface [polypeptide binding]; other site 931626010111 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931626010112 FtsX-like permease family; Region: FtsX; pfam02687 931626010113 FtsX-like permease family; Region: FtsX; pfam02687 931626010114 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626010115 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626010116 Walker A/P-loop; other site 931626010117 ATP binding site [chemical binding]; other site 931626010118 Q-loop/lid; other site 931626010119 ABC transporter signature motif; other site 931626010120 Walker B; other site 931626010121 D-loop; other site 931626010122 H-loop/switch region; other site 931626010123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626010124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626010125 dimer interface [polypeptide binding]; other site 931626010126 phosphorylation site [posttranslational modification] 931626010127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626010128 ATP binding site [chemical binding]; other site 931626010129 Mg2+ binding site [ion binding]; other site 931626010130 G-X-G motif; other site 931626010131 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626010132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626010133 active site 931626010134 phosphorylation site [posttranslational modification] 931626010135 intermolecular recognition site; other site 931626010136 dimerization interface [polypeptide binding]; other site 931626010137 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626010138 DNA binding site [nucleotide binding] 931626010139 Methyltransferase domain; Region: Methyltransf_23; pfam13489 931626010140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626010141 S-adenosylmethionine binding site [chemical binding]; other site 931626010142 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626010143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626010144 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 931626010145 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 931626010146 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 931626010147 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 931626010148 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 931626010149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 931626010150 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 931626010151 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 931626010152 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 931626010153 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09744 931626010154 CRISPR-associated protein Csx8 (Cas_Csx8); Region: Cas_Csx8; pfam09657 931626010155 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 931626010156 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 931626010157 Predicted transcriptional regulator [Transcription]; Region: COG2378 931626010158 WYL domain; Region: WYL; pfam13280 931626010159 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 931626010160 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 931626010161 dimerization domain swap beta strand [polypeptide binding]; other site 931626010162 regulatory protein interface [polypeptide binding]; other site 931626010163 active site 931626010164 regulatory phosphorylation site [posttranslational modification]; other site 931626010165 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 931626010166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626010167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626010168 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 931626010169 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 931626010170 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 931626010171 E3 interaction surface; other site 931626010172 lipoyl attachment site [posttranslational modification]; other site 931626010173 e3 binding domain; Region: E3_binding; pfam02817 931626010174 e3 binding domain; Region: E3_binding; pfam02817 931626010175 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 931626010176 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 931626010177 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 931626010178 alpha subunit interface [polypeptide binding]; other site 931626010179 TPP binding site [chemical binding]; other site 931626010180 heterodimer interface [polypeptide binding]; other site 931626010181 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931626010182 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 931626010183 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 931626010184 tetramer interface [polypeptide binding]; other site 931626010185 TPP-binding site [chemical binding]; other site 931626010186 heterodimer interface [polypeptide binding]; other site 931626010187 phosphorylation loop region [posttranslational modification] 931626010188 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 931626010189 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 931626010190 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 931626010191 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 931626010192 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 931626010193 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 931626010194 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 931626010195 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 931626010196 Glucitol operon activator protein (GutM); Region: GutM; cl01890 931626010197 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 931626010198 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 931626010199 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931626010200 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 931626010201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626010202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626010203 Helix-turn-helix domain; Region: HTH_17; pfam12728 931626010204 Fic family protein [Function unknown]; Region: COG3177 931626010205 Fic/DOC family; Region: Fic; pfam02661 931626010206 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 931626010207 amphipathic channel; other site 931626010208 Asn-Pro-Ala signature motifs; other site 931626010209 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 931626010210 Sel1-like repeats; Region: SEL1; smart00671 931626010211 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 931626010212 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 931626010213 Sel1-like repeats; Region: SEL1; smart00671 931626010214 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 931626010215 Sel1-like repeats; Region: SEL1; smart00671 931626010216 Sel1-like repeats; Region: SEL1; smart00671 931626010217 Sel1-like repeats; Region: SEL1; smart00671 931626010218 GMP synthase; Reviewed; Region: guaA; PRK00074 931626010219 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 931626010220 AMP/PPi binding site [chemical binding]; other site 931626010221 candidate oxyanion hole; other site 931626010222 catalytic triad [active] 931626010223 potential glutamine specificity residues [chemical binding]; other site 931626010224 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 931626010225 ATP Binding subdomain [chemical binding]; other site 931626010226 Ligand Binding sites [chemical binding]; other site 931626010227 Dimerization subdomain; other site 931626010228 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 931626010229 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 931626010230 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 931626010231 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 931626010232 active site 931626010233 e3 binding domain; Region: E3_binding; pfam02817 931626010234 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 931626010235 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 931626010236 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 931626010237 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 931626010238 alpha subunit interface [polypeptide binding]; other site 931626010239 TPP binding site [chemical binding]; other site 931626010240 heterodimer interface [polypeptide binding]; other site 931626010241 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 931626010242 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 931626010243 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 931626010244 tetramer interface [polypeptide binding]; other site 931626010245 TPP-binding site [chemical binding]; other site 931626010246 heterodimer interface [polypeptide binding]; other site 931626010247 phosphorylation loop region [posttranslational modification] 931626010248 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 931626010249 substrate binding site; other site 931626010250 dimer interface; other site 931626010251 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 931626010252 PspC domain; Region: PspC; pfam04024 931626010253 aminotransferase AlaT; Validated; Region: PRK09265 931626010254 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626010255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626010256 homodimer interface [polypeptide binding]; other site 931626010257 catalytic residue [active] 931626010258 Trp repressor protein; Region: Trp_repressor; cl17266 931626010259 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 931626010260 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 931626010261 active site 931626010262 HIGH motif; other site 931626010263 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 931626010264 KMSKS motif; other site 931626010265 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 931626010266 tRNA binding surface [nucleotide binding]; other site 931626010267 anticodon binding site; other site 931626010268 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 931626010269 dimerization interface [polypeptide binding]; other site 931626010270 active site 931626010271 metal binding site [ion binding]; metal-binding site 931626010272 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931626010273 putative efflux protein, MATE family; Region: matE; TIGR00797 931626010274 helicase 45; Provisional; Region: PTZ00424 931626010275 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 931626010276 ATP binding site [chemical binding]; other site 931626010277 Mg++ binding site [ion binding]; other site 931626010278 motif III; other site 931626010279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931626010280 nucleotide binding region [chemical binding]; other site 931626010281 ATP-binding site [chemical binding]; other site 931626010282 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 931626010283 RNA binding site [nucleotide binding]; other site 931626010284 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626010285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626010286 non-specific DNA binding site [nucleotide binding]; other site 931626010287 salt bridge; other site 931626010288 sequence-specific DNA binding site [nucleotide binding]; other site 931626010289 NAD synthetase; Reviewed; Region: nadE; PRK02628 931626010290 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 931626010291 multimer interface [polypeptide binding]; other site 931626010292 active site 931626010293 catalytic triad [active] 931626010294 protein interface 1 [polypeptide binding]; other site 931626010295 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 931626010296 homodimer interface [polypeptide binding]; other site 931626010297 NAD binding pocket [chemical binding]; other site 931626010298 ATP binding pocket [chemical binding]; other site 931626010299 Mg binding site [ion binding]; other site 931626010300 active-site loop [active] 931626010301 CTP synthetase; Validated; Region: pyrG; PRK05380 931626010302 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 931626010303 Catalytic site [active] 931626010304 active site 931626010305 UTP binding site [chemical binding]; other site 931626010306 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 931626010307 active site 931626010308 putative oxyanion hole; other site 931626010309 catalytic triad [active] 931626010310 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 931626010311 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 931626010312 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 931626010313 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 931626010314 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 931626010315 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 931626010316 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931626010317 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 931626010318 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 931626010319 FMN binding site [chemical binding]; other site 931626010320 active site 931626010321 catalytic residues [active] 931626010322 substrate binding site [chemical binding]; other site 931626010323 pantothenate kinase; Reviewed; Region: PRK13318 931626010324 Predicted thioesterase [General function prediction only]; Region: COG5496 931626010325 FtsH Extracellular; Region: FtsH_ext; pfam06480 931626010326 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 931626010327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626010328 Walker A motif; other site 931626010329 ATP binding site [chemical binding]; other site 931626010330 Walker B motif; other site 931626010331 arginine finger; other site 931626010332 Peptidase family M41; Region: Peptidase_M41; pfam01434 931626010333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931626010334 active site 931626010335 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 931626010336 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 931626010337 Ligand Binding Site [chemical binding]; other site 931626010338 TilS substrate C-terminal domain; Region: TilS_C; smart00977 931626010339 exopolyphosphatase; Region: exo_poly_only; TIGR03706 931626010340 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 931626010341 Septum formation initiator; Region: DivIC; pfam04977 931626010342 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 931626010343 RNA binding surface [nucleotide binding]; other site 931626010344 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 931626010345 IHF - DNA interface [nucleotide binding]; other site 931626010346 IHF dimer interface [polypeptide binding]; other site 931626010347 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 931626010348 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 931626010349 homodimer interface [polypeptide binding]; other site 931626010350 active site 931626010351 SAM binding site [chemical binding]; other site 931626010352 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 931626010353 homodimer interface [polypeptide binding]; other site 931626010354 metal binding site [ion binding]; metal-binding site 931626010355 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 931626010356 homodimer interface [polypeptide binding]; other site 931626010357 active site 931626010358 putative chemical substrate binding site [chemical binding]; other site 931626010359 metal binding site [ion binding]; metal-binding site 931626010360 stage V sporulation protein B; Region: spore_V_B; TIGR02900 931626010361 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 931626010362 SurA N-terminal domain; Region: SurA_N_3; cl07813 931626010363 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 931626010364 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 931626010365 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 931626010366 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 931626010367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 931626010368 ATP binding site [chemical binding]; other site 931626010369 putative Mg++ binding site [ion binding]; other site 931626010370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 931626010371 nucleotide binding region [chemical binding]; other site 931626010372 ATP-binding site [chemical binding]; other site 931626010373 TRCF domain; Region: TRCF; pfam03461 931626010374 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 931626010375 putative active site [active] 931626010376 catalytic residue [active] 931626010377 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 931626010378 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 931626010379 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931626010380 active site 931626010381 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 931626010382 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 931626010383 Substrate binding site; other site 931626010384 Mg++ binding site; other site 931626010385 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 931626010386 active site 931626010387 substrate binding site [chemical binding]; other site 931626010388 CoA binding site [chemical binding]; other site 931626010389 SpoVG; Region: SpoVG; cl00915 931626010390 pur operon repressor; Provisional; Region: PRK09213 931626010391 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 931626010392 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 931626010393 active site 931626010394 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 931626010395 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 931626010396 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 931626010397 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 931626010398 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 931626010399 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 931626010400 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 931626010401 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 931626010402 active site 931626010403 nucleophile elbow; other site 931626010404 hypothetical protein; Provisional; Region: PRK05590 931626010405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626010406 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 931626010407 Predicted transcriptional regulators [Transcription]; Region: COG1725 931626010408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626010409 DNA-binding site [nucleotide binding]; DNA binding site 931626010410 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 931626010411 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626010412 Walker A/P-loop; other site 931626010413 ATP binding site [chemical binding]; other site 931626010414 Q-loop/lid; other site 931626010415 ABC transporter signature motif; other site 931626010416 Walker B; other site 931626010417 D-loop; other site 931626010418 H-loop/switch region; other site 931626010419 HlyD family secretion protein; Region: HlyD_3; pfam13437 931626010420 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626010421 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626010422 Walker A/P-loop; other site 931626010423 ATP binding site [chemical binding]; other site 931626010424 Q-loop/lid; other site 931626010425 ABC transporter signature motif; other site 931626010426 Walker B; other site 931626010427 D-loop; other site 931626010428 H-loop/switch region; other site 931626010429 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626010430 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 931626010431 FtsX-like permease family; Region: FtsX; pfam02687 931626010432 A new structural DNA glycosylase; Region: AlkD_like; cd06561 931626010433 active site 931626010434 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 931626010435 homotrimer interface [polypeptide binding]; other site 931626010436 Walker A motif; other site 931626010437 GTP binding site [chemical binding]; other site 931626010438 Walker B motif; other site 931626010439 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 931626010440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626010441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626010442 homodimer interface [polypeptide binding]; other site 931626010443 catalytic residue [active] 931626010444 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 931626010445 cobyric acid synthase; Provisional; Region: PRK00784 931626010446 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 931626010447 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 931626010448 catalytic triad [active] 931626010449 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 931626010450 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 931626010451 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 931626010452 active site 931626010453 SAM binding site [chemical binding]; other site 931626010454 homodimer interface [polypeptide binding]; other site 931626010455 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 931626010456 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 931626010457 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 931626010458 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 931626010459 active site 931626010460 SAM binding site [chemical binding]; other site 931626010461 homodimer interface [polypeptide binding]; other site 931626010462 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 931626010463 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 931626010464 active site 931626010465 C-terminal domain interface [polypeptide binding]; other site 931626010466 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 931626010467 active site 931626010468 N-terminal domain interface [polypeptide binding]; other site 931626010469 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 931626010470 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 931626010471 inhibitor-cofactor binding pocket; inhibition site 931626010472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626010473 catalytic residue [active] 931626010474 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 931626010475 dimer interface [polypeptide binding]; other site 931626010476 active site 931626010477 Schiff base residues; other site 931626010478 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 931626010479 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 931626010480 domain interfaces; other site 931626010481 active site 931626010482 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 931626010483 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 931626010484 active site 931626010485 SAM binding site [chemical binding]; other site 931626010486 homodimer interface [polypeptide binding]; other site 931626010487 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 931626010488 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 931626010489 active site 931626010490 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 931626010491 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 931626010492 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 931626010493 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 931626010494 tRNA; other site 931626010495 putative tRNA binding site [nucleotide binding]; other site 931626010496 putative NADP binding site [chemical binding]; other site 931626010497 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 931626010498 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626010499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626010500 metal binding site [ion binding]; metal-binding site 931626010501 active site 931626010502 I-site; other site 931626010503 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626010504 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 931626010505 FtsX-like permease family; Region: FtsX; pfam02687 931626010506 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626010507 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626010508 Walker A/P-loop; other site 931626010509 ATP binding site [chemical binding]; other site 931626010510 Q-loop/lid; other site 931626010511 ABC transporter signature motif; other site 931626010512 Walker B; other site 931626010513 D-loop; other site 931626010514 H-loop/switch region; other site 931626010515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626010516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626010517 ATP binding site [chemical binding]; other site 931626010518 Mg2+ binding site [ion binding]; other site 931626010519 G-X-G motif; other site 931626010520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626010521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626010522 active site 931626010523 phosphorylation site [posttranslational modification] 931626010524 intermolecular recognition site; other site 931626010525 dimerization interface [polypeptide binding]; other site 931626010526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626010527 DNA binding site [nucleotide binding] 931626010528 PAS domain S-box; Region: sensory_box; TIGR00229 931626010529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626010530 putative active site [active] 931626010531 heme pocket [chemical binding]; other site 931626010532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626010533 PAS fold; Region: PAS_3; pfam08447 931626010534 putative active site [active] 931626010535 heme pocket [chemical binding]; other site 931626010536 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626010537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626010538 metal binding site [ion binding]; metal-binding site 931626010539 active site 931626010540 I-site; other site 931626010541 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626010542 Zn2+ binding site [ion binding]; other site 931626010543 Mg2+ binding site [ion binding]; other site 931626010544 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 931626010545 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 931626010546 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 931626010547 catalytic triad [active] 931626010548 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 931626010549 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626010550 FtsX-like permease family; Region: FtsX; pfam02687 931626010551 FtsX-like permease family; Region: FtsX; pfam02687 931626010552 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 931626010553 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626010554 Walker A/P-loop; other site 931626010555 ATP binding site [chemical binding]; other site 931626010556 Q-loop/lid; other site 931626010557 ABC transporter signature motif; other site 931626010558 Walker B; other site 931626010559 D-loop; other site 931626010560 H-loop/switch region; other site 931626010561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626010562 dimer interface [polypeptide binding]; other site 931626010563 phosphorylation site [posttranslational modification] 931626010564 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 931626010565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626010566 ATP binding site [chemical binding]; other site 931626010567 Mg2+ binding site [ion binding]; other site 931626010568 G-X-G motif; other site 931626010569 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626010570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626010571 active site 931626010572 phosphorylation site [posttranslational modification] 931626010573 intermolecular recognition site; other site 931626010574 dimerization interface [polypeptide binding]; other site 931626010575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626010576 DNA binding site [nucleotide binding] 931626010577 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 931626010578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626010579 S-adenosylmethionine binding site [chemical binding]; other site 931626010580 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 931626010581 active site 931626010582 putative homodimer interface [polypeptide binding]; other site 931626010583 SAM binding site [chemical binding]; other site 931626010584 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 931626010585 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 931626010586 active site 931626010587 SAM binding site [chemical binding]; other site 931626010588 homodimer interface [polypeptide binding]; other site 931626010589 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 931626010590 Precorrin-8X methylmutase; Region: CbiC; pfam02570 931626010591 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 931626010592 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 931626010593 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 931626010594 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626010595 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 931626010596 catalytic triad [active] 931626010597 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 931626010598 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 931626010599 Walker A/P-loop; other site 931626010600 ATP binding site [chemical binding]; other site 931626010601 Q-loop/lid; other site 931626010602 ABC transporter signature motif; other site 931626010603 Walker B; other site 931626010604 D-loop; other site 931626010605 H-loop/switch region; other site 931626010606 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 931626010607 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 931626010608 ABC-ATPase subunit interface; other site 931626010609 dimer interface [polypeptide binding]; other site 931626010610 putative PBP binding regions; other site 931626010611 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 931626010612 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 931626010613 putative binding site residues; other site 931626010614 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626010615 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626010616 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626010617 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 931626010618 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 931626010619 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 931626010620 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931626010621 Walker A/P-loop; other site 931626010622 ATP binding site [chemical binding]; other site 931626010623 Q-loop/lid; other site 931626010624 ABC transporter signature motif; other site 931626010625 Walker B; other site 931626010626 D-loop; other site 931626010627 H-loop/switch region; other site 931626010628 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 931626010629 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 931626010630 Walker A/P-loop; other site 931626010631 ATP binding site [chemical binding]; other site 931626010632 Q-loop/lid; other site 931626010633 ABC transporter signature motif; other site 931626010634 Walker B; other site 931626010635 D-loop; other site 931626010636 H-loop/switch region; other site 931626010637 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 931626010638 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 931626010639 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626010640 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 931626010641 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 931626010642 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 931626010643 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626010644 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010645 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010646 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010647 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 931626010648 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931626010649 Metal-binding active site; metal-binding site 931626010650 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626010651 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010652 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010653 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010654 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626010655 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010656 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626010657 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010658 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626010659 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010660 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626010661 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010662 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 931626010663 CpXC protein; Region: CpXC; pfam14353 931626010664 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626010665 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626010666 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 931626010667 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 931626010668 DNA interaction; other site 931626010669 Metal-binding active site; metal-binding site 931626010670 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 931626010671 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931626010672 active site 931626010673 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 931626010674 FAD dependent oxidoreductase; Region: DAO; pfam01266 931626010675 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 931626010676 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 931626010677 inhibitor-cofactor binding pocket; inhibition site 931626010678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626010679 catalytic residue [active] 931626010680 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 931626010681 active site 931626010682 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 931626010683 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 931626010684 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 931626010685 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 931626010686 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 931626010687 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 931626010688 GGGtGRT protein; Region: GGGtGRT; pfam14057 931626010689 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 931626010690 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626010691 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010692 Clostridial hydrophobic W; Region: ChW; pfam07538 931626010693 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626010694 Peptidase M15; Region: Peptidase_M15_3; cl01194 931626010695 Holin family; Region: Phage_holin_4; pfam05105 931626010696 Phage tail protein; Region: Sipho_tail; pfam05709 931626010697 Phage-related minor tail protein [Function unknown]; Region: COG5280 931626010698 Phage-related protein [Function unknown]; Region: COG5412 931626010699 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 931626010700 Peptidase family M23; Region: Peptidase_M23; pfam01551 931626010701 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 931626010702 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 931626010703 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 931626010704 Phage capsid family; Region: Phage_capsid; pfam05065 931626010705 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 931626010706 oligomer interface [polypeptide binding]; other site 931626010707 active site residues [active] 931626010708 Phage portal protein; Region: Phage_portal; pfam04860 931626010709 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 931626010710 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 931626010711 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 931626010712 active site 931626010713 AAA domain; Region: AAA_33; pfam13671 931626010714 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931626010715 active site 931626010716 DNA binding site [nucleotide binding] 931626010717 Int/Topo IB signature motif; other site 931626010718 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 931626010719 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 931626010720 cofactor binding site; other site 931626010721 DNA binding site [nucleotide binding] 931626010722 substrate interaction site [chemical binding]; other site 931626010723 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626010724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626010725 non-specific DNA binding site [nucleotide binding]; other site 931626010726 salt bridge; other site 931626010727 sequence-specific DNA binding site [nucleotide binding]; other site 931626010728 hypothetical protein; Validated; Region: PRK08116 931626010729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626010730 Walker A motif; other site 931626010731 ATP binding site [chemical binding]; other site 931626010732 Walker B motif; other site 931626010733 arginine finger; other site 931626010734 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626010735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626010736 salt bridge; other site 931626010737 non-specific DNA binding site [nucleotide binding]; other site 931626010738 sequence-specific DNA binding site [nucleotide binding]; other site 931626010739 Helix-turn-helix domain; Region: HTH_17; cl17695 931626010740 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 931626010741 catalytic site [active] 931626010742 metal binding site [ion binding]; metal-binding site 931626010743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626010744 non-specific DNA binding site [nucleotide binding]; other site 931626010745 salt bridge; other site 931626010746 sequence-specific DNA binding site [nucleotide binding]; other site 931626010747 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626010748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626010749 non-specific DNA binding site [nucleotide binding]; other site 931626010750 salt bridge; other site 931626010751 sequence-specific DNA binding site [nucleotide binding]; other site 931626010752 Domain of unknown function (DUF955); Region: DUF955; pfam06114 931626010753 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 931626010754 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 931626010755 active site 931626010756 catalytic residues [active] 931626010757 DNA binding site [nucleotide binding] 931626010758 Int/Topo IB signature motif; other site 931626010759 putative transposase OrfB; Reviewed; Region: PHA02517 931626010760 HTH-like domain; Region: HTH_21; pfam13276 931626010761 Integrase core domain; Region: rve; pfam00665 931626010762 Integrase core domain; Region: rve_3; pfam13683 931626010763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931626010764 Transposase; Region: HTH_Tnp_1; pfam01527 931626010765 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 931626010766 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 931626010767 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 931626010768 RelB antitoxin; Region: RelB; cl01171 931626010769 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626010770 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626010771 metal binding site [ion binding]; metal-binding site 931626010772 active site 931626010773 I-site; other site 931626010774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626010775 putative substrate translocation pore; other site 931626010776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626010777 Isochorismatase family; Region: Isochorismatase; pfam00857 931626010778 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 931626010779 catalytic triad [active] 931626010780 conserved cis-peptide bond; other site 931626010781 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626010782 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626010783 Cache domain; Region: Cache_1; pfam02743 931626010784 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 931626010785 dimerization interface [polypeptide binding]; other site 931626010786 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 931626010787 Protein of unknown function (DUF3232); Region: DUF3232; pfam11554 931626010788 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626010789 dimer interface [polypeptide binding]; other site 931626010790 putative CheW interface [polypeptide binding]; other site 931626010791 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 931626010792 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 931626010793 phosphate binding site [ion binding]; other site 931626010794 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931626010795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 931626010796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626010797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626010798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626010799 Divergent AAA domain; Region: AAA_4; pfam04326 931626010800 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 931626010801 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 931626010802 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931626010803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931626010804 DNA binding residues [nucleotide binding] 931626010805 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931626010806 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 931626010807 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931626010808 active site 931626010809 FMN binding site [chemical binding]; other site 931626010810 substrate binding site [chemical binding]; other site 931626010811 putative catalytic residue [active] 931626010812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931626010813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626010814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626010815 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 931626010816 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 931626010817 classical (c) SDRs; Region: SDR_c; cd05233 931626010818 NAD(P) binding site [chemical binding]; other site 931626010819 active site 931626010820 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931626010821 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931626010822 Walker A/P-loop; other site 931626010823 ATP binding site [chemical binding]; other site 931626010824 Q-loop/lid; other site 931626010825 ABC transporter signature motif; other site 931626010826 Walker B; other site 931626010827 D-loop; other site 931626010828 H-loop/switch region; other site 931626010829 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626010830 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626010831 substrate binding pocket [chemical binding]; other site 931626010832 membrane-bound complex binding site; other site 931626010833 hinge residues; other site 931626010834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626010835 dimer interface [polypeptide binding]; other site 931626010836 conserved gate region; other site 931626010837 putative PBP binding loops; other site 931626010838 ABC-ATPase subunit interface; other site 931626010839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626010840 dimer interface [polypeptide binding]; other site 931626010841 conserved gate region; other site 931626010842 putative PBP binding loops; other site 931626010843 ABC-ATPase subunit interface; other site 931626010844 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626010845 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626010846 metal binding site [ion binding]; metal-binding site 931626010847 active site 931626010848 I-site; other site 931626010849 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 931626010850 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 931626010851 DNA binding site [nucleotide binding] 931626010852 catalytic residue [active] 931626010853 H2TH interface [polypeptide binding]; other site 931626010854 putative catalytic residues [active] 931626010855 turnover-facilitating residue; other site 931626010856 intercalation triad [nucleotide binding]; other site 931626010857 8OG recognition residue [nucleotide binding]; other site 931626010858 putative reading head residues; other site 931626010859 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 931626010860 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 931626010861 Putative zinc-finger; Region: zf-HC2; pfam13490 931626010862 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 931626010863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 931626010864 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 931626010865 DNA binding residues [nucleotide binding] 931626010866 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626010867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626010868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626010869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626010870 Coenzyme A binding pocket [chemical binding]; other site 931626010871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626010872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626010873 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 931626010874 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 931626010875 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 931626010876 active site 931626010877 Response regulator receiver domain; Region: Response_reg; pfam00072 931626010878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626010879 active site 931626010880 phosphorylation site [posttranslational modification] 931626010881 intermolecular recognition site; other site 931626010882 dimerization interface [polypeptide binding]; other site 931626010883 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 931626010884 dimer interface [polypeptide binding]; other site 931626010885 FMN binding site [chemical binding]; other site 931626010886 NADPH bind site [chemical binding]; other site 931626010887 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 931626010888 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931626010889 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931626010890 Walker A/P-loop; other site 931626010891 ATP binding site [chemical binding]; other site 931626010892 Q-loop/lid; other site 931626010893 ABC transporter signature motif; other site 931626010894 Walker B; other site 931626010895 D-loop; other site 931626010896 H-loop/switch region; other site 931626010897 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 931626010898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626010899 dimer interface [polypeptide binding]; other site 931626010900 conserved gate region; other site 931626010901 putative PBP binding loops; other site 931626010902 ABC-ATPase subunit interface; other site 931626010903 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626010904 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626010905 substrate binding pocket [chemical binding]; other site 931626010906 membrane-bound complex binding site; other site 931626010907 hinge residues; other site 931626010908 CAAX protease self-immunity; Region: Abi; pfam02517 931626010909 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626010910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626010911 non-specific DNA binding site [nucleotide binding]; other site 931626010912 salt bridge; other site 931626010913 sequence-specific DNA binding site [nucleotide binding]; other site 931626010914 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626010915 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626010916 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 931626010917 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626010918 Predicted permease; Region: DUF318; cl17795 931626010919 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 931626010920 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 931626010921 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 931626010922 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 931626010923 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 931626010924 AAA ATPase domain; Region: AAA_16; pfam13191 931626010925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 931626010926 binding surface 931626010927 TPR motif; other site 931626010928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931626010929 DNA binding residues [nucleotide binding] 931626010930 dimerization interface [polypeptide binding]; other site 931626010931 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931626010932 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931626010933 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626010934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626010935 Walker A/P-loop; other site 931626010936 ATP binding site [chemical binding]; other site 931626010937 Q-loop/lid; other site 931626010938 ABC transporter signature motif; other site 931626010939 Walker B; other site 931626010940 D-loop; other site 931626010941 H-loop/switch region; other site 931626010942 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 931626010943 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626010944 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626010945 Predicted transcriptional regulators [Transcription]; Region: COG1695 931626010946 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 931626010947 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 931626010948 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931626010949 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 931626010950 DNA binding residues [nucleotide binding] 931626010951 drug binding residues [chemical binding]; other site 931626010952 dimer interface [polypeptide binding]; other site 931626010953 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931626010954 Creatinine amidohydrolase; Region: Creatininase; pfam02633 931626010955 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 931626010956 drug efflux system protein MdtG; Provisional; Region: PRK09874 931626010957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626010958 putative substrate translocation pore; other site 931626010959 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931626010960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626010961 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626010962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626010963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626010964 Major Facilitator Superfamily; Region: MFS_1; pfam07690 931626010965 putative substrate translocation pore; other site 931626010966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626010967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626010968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626010969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931626010970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626010971 active site 931626010972 phosphorylation site [posttranslational modification] 931626010973 intermolecular recognition site; other site 931626010974 dimerization interface [polypeptide binding]; other site 931626010975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931626010976 DNA binding residues [nucleotide binding] 931626010977 dimerization interface [polypeptide binding]; other site 931626010978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 931626010979 Histidine kinase; Region: HisKA_3; pfam07730 931626010980 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931626010981 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931626010982 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 931626010983 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 931626010984 nodulation ABC transporter NodI; Provisional; Region: PRK13537 931626010985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626010986 Walker A/P-loop; other site 931626010987 ATP binding site [chemical binding]; other site 931626010988 Q-loop/lid; other site 931626010989 ABC transporter signature motif; other site 931626010990 Walker B; other site 931626010991 D-loop; other site 931626010992 H-loop/switch region; other site 931626010993 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626010994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626010995 non-specific DNA binding site [nucleotide binding]; other site 931626010996 salt bridge; other site 931626010997 sequence-specific DNA binding site [nucleotide binding]; other site 931626010998 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 931626010999 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 931626011000 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 931626011001 Walker A/P-loop; other site 931626011002 ATP binding site [chemical binding]; other site 931626011003 Q-loop/lid; other site 931626011004 ABC transporter signature motif; other site 931626011005 Walker B; other site 931626011006 D-loop; other site 931626011007 H-loop/switch region; other site 931626011008 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 931626011009 Chloramphenicol acetyltransferase; Region: CAT; smart01059 931626011010 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 931626011011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626011012 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626011013 salt bridge; other site 931626011014 non-specific DNA binding site [nucleotide binding]; other site 931626011015 sequence-specific DNA binding site [nucleotide binding]; other site 931626011016 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 931626011017 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 931626011018 non-heme iron binding site [ion binding]; other site 931626011019 hypothetical protein; Provisional; Region: PRK04164 931626011020 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 931626011021 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 931626011022 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 931626011023 CheW-like domain; Region: CheW; pfam01584 931626011024 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 931626011025 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 931626011026 Walker A/P-loop; other site 931626011027 ATP binding site [chemical binding]; other site 931626011028 Q-loop/lid; other site 931626011029 ABC transporter signature motif; other site 931626011030 Walker B; other site 931626011031 D-loop; other site 931626011032 H-loop/switch region; other site 931626011033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626011034 membrane-bound complex binding site; other site 931626011035 hinge residues; other site 931626011036 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626011037 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626011038 substrate binding pocket [chemical binding]; other site 931626011039 membrane-bound complex binding site; other site 931626011040 hinge residues; other site 931626011041 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626011042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626011043 substrate binding pocket [chemical binding]; other site 931626011044 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 931626011045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 931626011046 dimer interface [polypeptide binding]; other site 931626011047 conserved gate region; other site 931626011048 putative PBP binding loops; other site 931626011049 ABC-ATPase subunit interface; other site 931626011050 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626011051 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626011052 membrane-bound complex binding site; other site 931626011053 hinge residues; other site 931626011054 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 931626011055 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 931626011056 substrate binding pocket [chemical binding]; other site 931626011057 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 931626011058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931626011059 DNA binding residues [nucleotide binding] 931626011060 dimerization interface [polypeptide binding]; other site 931626011061 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 931626011062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 931626011063 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 931626011064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626011065 Coenzyme A binding pocket [chemical binding]; other site 931626011066 HAMP domain; Region: HAMP; pfam00672 931626011067 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 931626011068 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 931626011069 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931626011070 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931626011071 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 931626011072 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 931626011073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011074 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 931626011075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011077 WHG domain; Region: WHG; pfam13305 931626011078 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931626011079 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 931626011080 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931626011081 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 931626011082 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 931626011083 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 931626011084 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626011085 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 931626011086 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 931626011087 putative active site [active] 931626011088 metal binding site [ion binding]; metal-binding site 931626011089 Protein of unknown function DUF111; Region: DUF111; pfam01969 931626011090 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 931626011091 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931626011092 active site 931626011093 catalytic tetrad [active] 931626011094 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626011095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011097 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 931626011098 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931626011099 DNA binding residues [nucleotide binding] 931626011100 putative dimer interface [polypeptide binding]; other site 931626011101 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 931626011102 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 931626011103 active site 931626011104 catalytic tetrad [active] 931626011105 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626011106 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 931626011107 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 931626011108 Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248 931626011109 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 931626011110 Transcriptional regulators [Transcription]; Region: MarR; COG1846 931626011111 MarR family; Region: MarR_2; pfam12802 931626011112 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931626011113 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931626011114 active site 931626011115 FMN binding site [chemical binding]; other site 931626011116 substrate binding site [chemical binding]; other site 931626011117 putative catalytic residue [active] 931626011118 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626011119 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626011120 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 931626011121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626011122 FeS/SAM binding site; other site 931626011123 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 931626011124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626011125 active site 931626011126 phosphorylation site [posttranslational modification] 931626011127 intermolecular recognition site; other site 931626011128 dimerization interface [polypeptide binding]; other site 931626011129 LytTr DNA-binding domain; Region: LytTR; smart00850 931626011130 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 931626011131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626011132 ATP binding site [chemical binding]; other site 931626011133 Mg2+ binding site [ion binding]; other site 931626011134 G-X-G motif; other site 931626011135 CAAX protease self-immunity; Region: Abi; pfam02517 931626011136 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 931626011137 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 931626011138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626011141 non-specific DNA binding site [nucleotide binding]; other site 931626011142 salt bridge; other site 931626011143 sequence-specific DNA binding site [nucleotide binding]; other site 931626011144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626011145 non-specific DNA binding site [nucleotide binding]; other site 931626011146 salt bridge; other site 931626011147 sequence-specific DNA binding site [nucleotide binding]; other site 931626011148 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 931626011149 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931626011150 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 931626011151 DNA binding residues [nucleotide binding] 931626011152 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626011153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 931626011155 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 931626011156 dimer interface [polypeptide binding]; other site 931626011157 FMN binding site [chemical binding]; other site 931626011158 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626011159 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 931626011160 Walker A/P-loop; other site 931626011161 ATP binding site [chemical binding]; other site 931626011162 Q-loop/lid; other site 931626011163 ABC transporter signature motif; other site 931626011164 Walker B; other site 931626011165 D-loop; other site 931626011166 H-loop/switch region; other site 931626011167 FtsX-like permease family; Region: FtsX; pfam02687 931626011168 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 931626011169 FtsX-like permease family; Region: FtsX; pfam02687 931626011170 H+ Antiporter protein; Region: 2A0121; TIGR00900 931626011171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626011172 putative substrate translocation pore; other site 931626011173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011175 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931626011176 Cache domain; Region: Cache_1; pfam02743 931626011177 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626011178 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626011179 metal binding site [ion binding]; metal-binding site 931626011180 active site 931626011181 I-site; other site 931626011182 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 931626011183 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626011184 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626011185 metal binding site [ion binding]; metal-binding site 931626011186 active site 931626011187 I-site; other site 931626011188 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 931626011189 Hemerythrin; Region: Hemerythrin; cd12107 931626011190 Fe binding site [ion binding]; other site 931626011191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626011192 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 931626011193 putative substrate translocation pore; other site 931626011194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626011195 H+ Antiporter protein; Region: 2A0121; TIGR00900 931626011196 putative substrate translocation pore; other site 931626011197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626011198 PAS domain; Region: PAS_9; pfam13426 931626011199 putative active site [active] 931626011200 heme pocket [chemical binding]; other site 931626011201 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626011202 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626011203 metal binding site [ion binding]; metal-binding site 931626011204 active site 931626011205 I-site; other site 931626011206 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626011207 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626011208 Zn2+ binding site [ion binding]; other site 931626011209 Mg2+ binding site [ion binding]; other site 931626011210 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626011211 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626011212 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 931626011213 tetramer interface [polypeptide binding]; other site 931626011214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626011215 catalytic residue [active] 931626011216 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 931626011217 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 931626011218 tetramer interface [polypeptide binding]; other site 931626011219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626011220 catalytic residue [active] 931626011221 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 931626011222 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 931626011223 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931626011224 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 931626011225 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626011226 catalytic residue [active] 931626011227 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 931626011228 lipoyl attachment site [posttranslational modification]; other site 931626011229 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 931626011230 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 931626011231 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 931626011232 ATP binding site [chemical binding]; other site 931626011233 Mg2+ binding site [ion binding]; other site 931626011234 G-X-G motif; other site 931626011235 Response regulator receiver domain; Region: Response_reg; pfam00072 931626011236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626011237 active site 931626011238 phosphorylation site [posttranslational modification] 931626011239 intermolecular recognition site; other site 931626011240 dimerization interface [polypeptide binding]; other site 931626011241 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 931626011242 methionine aminopeptidase; Provisional; Region: PRK12318 931626011243 SEC-C motif; Region: SEC-C; pfam02810 931626011244 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 931626011245 active site 931626011246 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626011247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011248 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 931626011249 Double zinc ribbon; Region: DZR; pfam12773 931626011250 Fn3 associated; Region: Fn3_assoc; pfam13287 931626011251 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 931626011252 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 931626011253 Protein of unknown function; Region: YhfT; pfam10797 931626011254 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 931626011255 Protein present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; smart00064 931626011256 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 931626011257 Double zinc ribbon; Region: DZR; pfam12773 931626011258 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 931626011259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626011260 putative substrate translocation pore; other site 931626011261 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 931626011262 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 931626011263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626011264 Walker A/P-loop; other site 931626011265 ATP binding site [chemical binding]; other site 931626011266 Q-loop/lid; other site 931626011267 ABC transporter signature motif; other site 931626011268 Walker B; other site 931626011269 D-loop; other site 931626011270 H-loop/switch region; other site 931626011271 TOBE domain; Region: TOBE_2; pfam08402 931626011272 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 931626011273 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 931626011274 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 931626011275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 931626011276 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 931626011277 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 931626011278 Double zinc ribbon; Region: DZR; pfam12773 931626011279 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 931626011280 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 931626011281 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 931626011282 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 931626011283 phosphate binding site [ion binding]; other site 931626011284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 931626011285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626011286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 931626011287 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 931626011288 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 931626011289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 931626011290 PAS fold; Region: PAS_3; pfam08447 931626011291 putative active site [active] 931626011292 heme pocket [chemical binding]; other site 931626011293 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626011294 metal binding site [ion binding]; metal-binding site 931626011295 active site 931626011296 I-site; other site 931626011297 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 931626011298 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 931626011299 catalytic residues [active] 931626011300 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 931626011301 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 931626011302 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 931626011303 DNA binding residues [nucleotide binding] 931626011304 drug binding residues [chemical binding]; other site 931626011305 dimer interface [polypeptide binding]; other site 931626011306 Creatinine amidohydrolase; Region: Creatininase; pfam02633 931626011307 Domain of unknown function (DU1801); Region: DUF1801; cl17490 931626011308 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 931626011309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626011310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 931626011312 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 931626011313 catalytic residue [active] 931626011314 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626011315 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626011316 metal binding site [ion binding]; metal-binding site 931626011317 active site 931626011318 I-site; other site 931626011319 PAS domain; Region: PAS_9; pfam13426 931626011320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 931626011321 dimerization interface [polypeptide binding]; other site 931626011322 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 931626011323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 931626011324 dimer interface [polypeptide binding]; other site 931626011325 putative CheW interface [polypeptide binding]; other site 931626011326 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 931626011327 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 931626011328 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 931626011329 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 931626011330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626011331 Walker A/P-loop; other site 931626011332 ATP binding site [chemical binding]; other site 931626011333 Q-loop/lid; other site 931626011334 ABC transporter signature motif; other site 931626011335 Walker B; other site 931626011336 D-loop; other site 931626011337 H-loop/switch region; other site 931626011338 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 931626011339 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 931626011340 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 931626011341 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 931626011342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626011343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931626011344 Coenzyme A binding pocket [chemical binding]; other site 931626011345 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 931626011346 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 931626011347 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 931626011348 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 931626011349 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 931626011350 trimer interface [polypeptide binding]; other site 931626011351 active site 931626011352 substrate binding site [chemical binding]; other site 931626011353 CoA binding site [chemical binding]; other site 931626011354 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 931626011355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 931626011356 DNA-binding site [nucleotide binding]; DNA binding site 931626011357 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626011358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626011359 homodimer interface [polypeptide binding]; other site 931626011360 catalytic residue [active] 931626011361 LysE type translocator; Region: LysE; cl00565 931626011362 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 931626011363 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 931626011364 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 931626011365 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 931626011366 Protein of unknown function; Region: DUF3658; pfam12395 931626011367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626011368 Coenzyme A binding pocket [chemical binding]; other site 931626011369 YoaP-like; Region: YoaP; pfam14268 931626011370 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 931626011371 Response regulator receiver domain; Region: Response_reg; pfam00072 931626011372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626011373 active site 931626011374 phosphorylation site [posttranslational modification] 931626011375 intermolecular recognition site; other site 931626011376 dimerization interface [polypeptide binding]; other site 931626011377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011379 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 931626011380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626011381 Walker A/P-loop; other site 931626011382 ATP binding site [chemical binding]; other site 931626011383 Q-loop/lid; other site 931626011384 ABC transporter signature motif; other site 931626011385 Walker B; other site 931626011386 D-loop; other site 931626011387 H-loop/switch region; other site 931626011388 Phosphotransferase enzyme family; Region: APH; pfam01636 931626011389 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 931626011390 active site 931626011391 substrate binding site [chemical binding]; other site 931626011392 ATP binding site [chemical binding]; other site 931626011393 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 931626011394 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 931626011395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 931626011396 motif II; other site 931626011397 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 931626011398 FlxA-like protein; Region: FlxA; pfam14282 931626011399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626011400 ATP binding site [chemical binding]; other site 931626011401 Mg2+ binding site [ion binding]; other site 931626011402 G-X-G motif; other site 931626011403 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 931626011404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626011405 active site 931626011406 phosphorylation site [posttranslational modification] 931626011407 intermolecular recognition site; other site 931626011408 dimerization interface [polypeptide binding]; other site 931626011409 LytTr DNA-binding domain; Region: LytTR; pfam04397 931626011410 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 931626011411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626011412 non-specific DNA binding site [nucleotide binding]; other site 931626011413 salt bridge; other site 931626011414 sequence-specific DNA binding site [nucleotide binding]; other site 931626011415 Cupin domain; Region: Cupin_2; pfam07883 931626011416 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 931626011417 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931626011418 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 931626011419 4Fe-4S binding domain; Region: Fer4; pfam00037 931626011420 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626011421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011423 Immunoglobulin domain; Region: Ig; cl11960 931626011424 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 931626011425 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931626011426 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626011427 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626011428 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 931626011429 FMN binding site [chemical binding]; other site 931626011430 dimer interface [polypeptide binding]; other site 931626011431 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 931626011432 dimer interface [polypeptide binding]; other site 931626011433 Uncharacterized conserved protein [Function unknown]; Region: COG1359 931626011434 Transcriptional regulators [Transcription]; Region: MarR; COG1846 931626011435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 931626011436 putative DNA binding site [nucleotide binding]; other site 931626011437 putative Zn2+ binding site [ion binding]; other site 931626011438 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 931626011439 active site flap/lid [active] 931626011440 nucleophilic elbow; other site 931626011441 catalytic triad [active] 931626011442 GTPase RsgA; Reviewed; Region: PRK01889 931626011443 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 931626011444 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 931626011445 GTPase/Zn-binding domain interface [polypeptide binding]; other site 931626011446 GTP/Mg2+ binding site [chemical binding]; other site 931626011447 G4 box; other site 931626011448 G5 box; other site 931626011449 G1 box; other site 931626011450 Switch I region; other site 931626011451 G2 box; other site 931626011452 G3 box; other site 931626011453 Switch II region; other site 931626011454 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 931626011455 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 931626011456 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 931626011457 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 931626011458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 931626011459 catalytic loop [active] 931626011460 iron binding site [ion binding]; other site 931626011461 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 931626011462 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 931626011463 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 931626011464 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626011465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626011466 metal binding site [ion binding]; metal-binding site 931626011467 active site 931626011468 I-site; other site 931626011469 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 931626011470 active site 931626011471 catalytic site [active] 931626011472 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 931626011473 glycosyltransferase; Provisional; Region: PRK13481 931626011474 Transglycosylase; Region: Transgly; pfam00912 931626011475 Penicillinase repressor; Region: Pencillinase_R; cl17580 931626011476 Divergent AAA domain; Region: AAA_4; pfam04326 931626011477 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 931626011478 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 931626011479 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626011480 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626011481 Clostridial hydrophobic W; Region: ChW; pfam07538 931626011482 Clostridial hydrophobic W; Region: ChW; pfam07538 931626011483 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 931626011484 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 931626011485 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931626011486 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 931626011487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011489 drug efflux system protein MdtG; Provisional; Region: PRK09874 931626011490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 931626011491 putative substrate translocation pore; other site 931626011492 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 931626011493 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 931626011494 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 931626011495 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 931626011496 ACS interaction site; other site 931626011497 CODH interaction site; other site 931626011498 metal cluster binding site [ion binding]; other site 931626011499 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; pfam03598 931626011500 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 931626011501 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 931626011502 PAS fold; Region: PAS_4; pfam08448 931626011503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626011504 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 931626011505 Walker A motif; other site 931626011506 ATP binding site [chemical binding]; other site 931626011507 Walker B motif; other site 931626011508 arginine finger; other site 931626011509 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 931626011510 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 931626011511 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 931626011512 active site 931626011513 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 931626011514 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 931626011515 NAD(P) binding site [chemical binding]; other site 931626011516 catalytic residues [active] 931626011517 GH3 auxin-responsive promoter; Region: GH3; pfam03321 931626011518 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 931626011519 GAF domain; Region: GAF_3; pfam13492 931626011520 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 931626011521 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 931626011522 metal binding site [ion binding]; metal-binding site 931626011523 active site 931626011524 I-site; other site 931626011525 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 931626011526 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 931626011527 Zn2+ binding site [ion binding]; other site 931626011528 Mg2+ binding site [ion binding]; other site 931626011529 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 931626011530 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 931626011531 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 931626011532 Peptidase family M23; Region: Peptidase_M23; pfam01551 931626011533 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 931626011534 myosin-cross-reactive antigen; Provisional; Region: PRK13977 931626011535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011536 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011537 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 931626011538 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 931626011539 Radical SAM superfamily; Region: Radical_SAM; pfam04055 931626011540 FeS/SAM binding site; other site 931626011541 RNHCP domain; Region: RNHCP; pfam12647 931626011542 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 931626011543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 931626011544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011545 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626011546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011547 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931626011548 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 931626011549 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 931626011550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626011551 Coenzyme A binding pocket [chemical binding]; other site 931626011552 Uncharacterized conserved protein [Function unknown]; Region: COG0397 931626011553 hypothetical protein; Validated; Region: PRK00029 931626011554 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 931626011555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 931626011556 Coenzyme A binding pocket [chemical binding]; other site 931626011557 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626011558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011561 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931626011562 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 931626011563 phosphate binding site [ion binding]; other site 931626011564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626011565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626011566 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 931626011567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626011568 Walker A/P-loop; other site 931626011569 ATP binding site [chemical binding]; other site 931626011570 Q-loop/lid; other site 931626011571 ABC transporter signature motif; other site 931626011572 Walker B; other site 931626011573 D-loop; other site 931626011574 H-loop/switch region; other site 931626011575 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 931626011576 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 931626011577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626011578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626011579 active site 931626011580 phosphorylation site [posttranslational modification] 931626011581 intermolecular recognition site; other site 931626011582 dimerization interface [polypeptide binding]; other site 931626011583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626011584 DNA binding site [nucleotide binding] 931626011585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626011586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 931626011587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626011588 dimer interface [polypeptide binding]; other site 931626011589 phosphorylation site [posttranslational modification] 931626011590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626011591 ATP binding site [chemical binding]; other site 931626011592 Mg2+ binding site [ion binding]; other site 931626011593 G-X-G motif; other site 931626011594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931626011595 Transposase; Region: HTH_Tnp_1; pfam01527 931626011596 putative transposase OrfB; Reviewed; Region: PHA02517 931626011597 HTH-like domain; Region: HTH_21; pfam13276 931626011598 Integrase core domain; Region: rve; pfam00665 931626011599 Integrase core domain; Region: rve_3; pfam13683 931626011600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 931626011601 Coenzyme A binding pocket [chemical binding]; other site 931626011602 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626011603 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626011604 Bacterial Ig-like domain; Region: Big_5; pfam13205 931626011605 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626011606 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626011607 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 931626011608 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626011609 Clostridial hydrophobic W; Region: ChW; pfam07538 931626011610 Clostridial hydrophobic W; Region: ChW; pfam07538 931626011611 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626011612 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 931626011613 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 931626011614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 931626011615 DNA binding residues [nucleotide binding] 931626011616 dimerization interface [polypeptide binding]; other site 931626011617 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 931626011618 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 931626011619 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 931626011620 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 931626011621 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 931626011622 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 931626011623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626011624 4Fe-4S binding domain; Region: Fer4; pfam00037 931626011625 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 931626011626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011628 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 931626011629 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 931626011630 pentamer interface [polypeptide binding]; other site 931626011631 dodecaamer interface [polypeptide binding]; other site 931626011632 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 931626011633 homotrimer interaction site [polypeptide binding]; other site 931626011634 putative active site [active] 931626011635 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 931626011636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 931626011637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 931626011638 homodimer interface [polypeptide binding]; other site 931626011639 catalytic residue [active] 931626011640 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 931626011641 MarR family; Region: MarR; pfam01047 931626011642 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 931626011643 anti sigma factor interaction site; other site 931626011644 regulatory phosphorylation site [posttranslational modification]; other site 931626011645 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 931626011646 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 931626011647 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626011648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626011649 Walker A/P-loop; other site 931626011650 ATP binding site [chemical binding]; other site 931626011651 Q-loop/lid; other site 931626011652 ABC transporter signature motif; other site 931626011653 Walker B; other site 931626011654 D-loop; other site 931626011655 H-loop/switch region; other site 931626011656 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 931626011657 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 931626011658 putative active site [active] 931626011659 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 931626011660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626011661 Walker A/P-loop; other site 931626011662 ATP binding site [chemical binding]; other site 931626011663 Q-loop/lid; other site 931626011664 ABC transporter signature motif; other site 931626011665 Walker B; other site 931626011666 D-loop; other site 931626011667 H-loop/switch region; other site 931626011668 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 931626011669 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 931626011670 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931626011671 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 931626011672 DNA binding residues [nucleotide binding] 931626011673 drug binding residues [chemical binding]; other site 931626011674 dimer interface [polypeptide binding]; other site 931626011675 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626011676 MarR family; Region: MarR; pfam01047 931626011677 Uncharacterized conserved protein [Function unknown]; Region: COG3791 931626011678 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 931626011679 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 931626011680 TAP-like protein; Region: Abhydrolase_4; pfam08386 931626011681 CAAX protease self-immunity; Region: Abi; pfam02517 931626011682 Helix-turn-helix domain; Region: HTH_17; pfam12728 931626011683 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 931626011684 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 931626011685 DNA binding residues [nucleotide binding] 931626011686 dimer interface [polypeptide binding]; other site 931626011687 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 931626011688 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 931626011689 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 931626011690 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 931626011691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011693 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 931626011694 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 931626011695 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 931626011696 active site 931626011697 FMN binding site [chemical binding]; other site 931626011698 substrate binding site [chemical binding]; other site 931626011699 putative catalytic residue [active] 931626011700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 931626011701 Winged helix-turn helix; Region: HTH_29; pfam13551 931626011702 Homeodomain-like domain; Region: HTH_32; pfam13565 931626011703 Integrase core domain; Region: rve; pfam00665 931626011704 Integrase core domain; Region: rve_3; pfam13683 931626011705 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 931626011706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626011707 Walker A motif; other site 931626011708 ATP binding site [chemical binding]; other site 931626011709 Walker B motif; other site 931626011710 arginine finger; other site 931626011711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 931626011712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 931626011713 dimer interface [polypeptide binding]; other site 931626011714 phosphorylation site [posttranslational modification] 931626011715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 931626011716 ATP binding site [chemical binding]; other site 931626011717 Mg2+ binding site [ion binding]; other site 931626011718 G-X-G motif; other site 931626011719 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 931626011720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 931626011721 active site 931626011722 phosphorylation site [posttranslational modification] 931626011723 intermolecular recognition site; other site 931626011724 dimerization interface [polypeptide binding]; other site 931626011725 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 931626011726 DNA binding site [nucleotide binding] 931626011727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 931626011728 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 931626011729 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626011730 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626011731 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 931626011732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011733 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 931626011734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 931626011735 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 931626011736 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 931626011737 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 931626011738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 931626011739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011740 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 931626011741 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626011742 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626011743 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 931626011744 Integrase core domain; Region: rve; pfam00665 931626011745 DDE domain; Region: DDE_Tnp_IS240; pfam13610 931626011746 Integrase core domain; Region: rve_3; pfam13683 931626011747 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 931626011748 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 931626011749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 931626011750 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 931626011751 Walker A/P-loop; other site 931626011752 ATP binding site [chemical binding]; other site 931626011753 Q-loop/lid; other site 931626011754 ABC transporter signature motif; other site 931626011755 Walker B; other site 931626011756 D-loop; other site 931626011757 H-loop/switch region; other site 931626011758 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 931626011759 MarR family; Region: MarR_2; pfam12802 931626011760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 931626011761 Transposase; Region: DDE_Tnp_ISL3; pfam01610 931626011762 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 931626011763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 931626011764 Walker A motif; other site 931626011765 ATP binding site [chemical binding]; other site 931626011766 Walker B motif; other site 931626011767 arginine finger; other site 931626011768 Winged helix-turn helix; Region: HTH_29; pfam13551 931626011769 Homeodomain-like domain; Region: HTH_32; pfam13565 931626011770 Integrase core domain; Region: rve; pfam00665 931626011771 Integrase core domain; Region: rve_3; pfam13683 931626011772 Transposase; Region: DDE_Tnp_ISL3; pfam01610 931626011773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 931626011774 HD domain; Region: HD_4; pfam13328 931626011775 Domain of unknown function DUF148; Region: DUF148; pfam02520 931626011776 putative transposase OrfB; Reviewed; Region: PHA02517 931626011777 HTH-like domain; Region: HTH_21; pfam13276 931626011778 Integrase core domain; Region: rve; pfam00665 931626011779 Integrase core domain; Region: rve_3; pfam13683 931626011780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931626011781 Transposase; Region: HTH_Tnp_1; pfam01527 931626011782 putative transposase OrfB; Reviewed; Region: PHA02517 931626011783 Integrase core domain; Region: rve_3; cl15866 931626011784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 931626011785 Transposase; Region: HTH_Tnp_1; pfam01527 931626011786 putative transposase OrfB; Reviewed; Region: PHA02517 931626011787 HTH-like domain; Region: HTH_21; pfam13276 931626011788 Integrase core domain; Region: rve; pfam00665 931626011789 Integrase core domain; Region: rve_3; pfam13683 931626011790 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 931626011791 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626011792 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626011793 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626011794 Clostridial hydrophobic W; Region: ChW; pfam07538 931626011795 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 931626011796 active site 931626011797 metal binding site [ion binding]; metal-binding site 931626011798 Holin family; Region: Phage_holin_4; pfam05105 931626011799 Phage tail protein; Region: Sipho_tail; pfam05709 931626011800 Phage-related minor tail protein [Function unknown]; Region: COG5280 931626011801 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 931626011802 Peptidase family M23; Region: Peptidase_M23; pfam01551 931626011803 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 931626011804 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 931626011805 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 931626011806 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 931626011807 Phage capsid family; Region: Phage_capsid; pfam05065 931626011808 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 931626011809 oligomer interface [polypeptide binding]; other site 931626011810 active site residues [active] 931626011811 Phage portal protein; Region: Phage_portal; pfam04860 931626011812 Phage-related protein [Function unknown]; Region: COG4695; cl01923 931626011813 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 931626011814 AAA domain; Region: AAA_33; pfam13671 931626011815 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931626011816 active site 931626011817 DNA binding site [nucleotide binding] 931626011818 Int/Topo IB signature motif; other site 931626011819 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 931626011820 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 931626011821 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 931626011822 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 931626011823 cofactor binding site; other site 931626011824 DNA binding site [nucleotide binding] 931626011825 substrate interaction site [chemical binding]; other site 931626011826 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626011827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626011828 salt bridge; other site 931626011829 non-specific DNA binding site [nucleotide binding]; other site 931626011830 sequence-specific DNA binding site [nucleotide binding]; other site 931626011831 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 931626011832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 931626011833 non-specific DNA binding site [nucleotide binding]; other site 931626011834 salt bridge; other site 931626011835 sequence-specific DNA binding site [nucleotide binding]; other site 931626011836 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 931626011837 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 931626011838 Clostridial hydrophobic W; Region: ChW; pfam07538 931626011839 Clostridial hydrophobic W; Region: ChW; pfam07538 931626011840 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 931626011841 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 931626011842 Int/Topo IB signature motif; other site 931626011843 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 931626011844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626011845 S-adenosylmethionine binding site [chemical binding]; other site 931626011846 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 931626011847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 931626011848 Predicted membrane protein [Function unknown]; Region: COG1511 931626011849 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 931626011850 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 931626011851 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 931626011852 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 931626011853 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 931626011854 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 931626011855 catalytic residues [active] 931626011856 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 931626011857 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 931626011858 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 931626011859 Rubredoxin; Region: Rubredoxin; pfam00301 931626011860 iron binding site [ion binding]; other site 931626011861 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 931626011862 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 931626011863 DNA polymerase III subunit delta'; Validated; Region: PRK08485 931626011864 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 931626011865 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 931626011866 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 931626011867 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 931626011868 catalytic residue [active] 931626011869 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 931626011870 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 931626011871 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 931626011872 TMP-binding site; other site 931626011873 ATP-binding site [chemical binding]; other site 931626011874 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 931626011875 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 931626011876 catalytic residues [active] 931626011877 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 931626011878 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 931626011879 active site 931626011880 HIGH motif; other site 931626011881 KMSKS motif; other site 931626011882 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 931626011883 tRNA binding surface [nucleotide binding]; other site 931626011884 anticodon binding site; other site 931626011885 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 931626011886 dimer interface [polypeptide binding]; other site 931626011887 putative tRNA-binding site [nucleotide binding]; other site 931626011888 Predicted methyltransferases [General function prediction only]; Region: COG0313 931626011889 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 931626011890 putative SAM binding site [chemical binding]; other site 931626011891 putative homodimer interface [polypeptide binding]; other site 931626011892 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 931626011893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 931626011894 replicative DNA helicase; Region: DnaB; TIGR00665 931626011895 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 931626011896 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 931626011897 Walker A motif; other site 931626011898 ATP binding site [chemical binding]; other site 931626011899 Walker B motif; other site 931626011900 DNA binding loops [nucleotide binding] 931626011901 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 931626011902 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 931626011903 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 931626011904 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 931626011905 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 931626011906 DHH family; Region: DHH; pfam01368 931626011907 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 931626011908 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 931626011909 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 931626011910 dimer interface [polypeptide binding]; other site 931626011911 ssDNA binding site [nucleotide binding]; other site 931626011912 tetramer (dimer of dimers) interface [polypeptide binding]; other site 931626011913 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 931626011914 Integral membrane protein DUF95; Region: DUF95; pfam01944 931626011915 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 931626011916 Mechanosensitive ion channel; Region: MS_channel; pfam00924 931626011917 Colicin V production protein; Region: Colicin_V; pfam02674 931626011918 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 931626011919 ParB-like nuclease domain; Region: ParB; smart00470 931626011920 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 931626011921 KorB domain; Region: KorB; pfam08535 931626011922 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 931626011923 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 931626011924 P-loop; other site 931626011925 Magnesium ion binding site [ion binding]; other site 931626011926 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 931626011927 Magnesium ion binding site [ion binding]; other site 931626011928 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 931626011929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 931626011930 S-adenosylmethionine binding site [chemical binding]; other site 931626011931 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 931626011932 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 931626011933 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 931626011934 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 931626011935 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 931626011936 trmE is a tRNA modification GTPase; Region: trmE; cd04164 931626011937 G1 box; other site 931626011938 GTP/Mg2+ binding site [chemical binding]; other site 931626011939 Switch I region; other site 931626011940 G2 box; other site 931626011941 Switch II region; other site 931626011942 G3 box; other site 931626011943 G4 box; other site 931626011944 G5 box; other site 931626011945 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 931626011946 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 931626011947 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 931626011948 G-X-X-G motif; other site 931626011949 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 931626011950 RxxxH motif; other site 931626011951 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 931626011952 Ribonuclease P; Region: Ribonuclease_P; pfam00825