-- dump date   	20140618_183830
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
634455000001	Transposase; Region: HTH_Tnp_1; pfam01527
634455000002	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
634455000003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634455000004	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634455000005	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634455000006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634455000007	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634455000008	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634455000009	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634455000010	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455000011	catalytic residues [active]
634455000012	catalytic nucleophile [active]
634455000013	Presynaptic Site I dimer interface [polypeptide binding]; other site
634455000014	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634455000015	Synaptic Flat tetramer interface [polypeptide binding]; other site
634455000016	Synaptic Site I dimer interface [polypeptide binding]; other site
634455000017	DDE superfamily endonuclease; Region: DDE_4; cl17710
634455000018	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634455000019	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
634455000020	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
634455000021	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
634455000022	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
634455000023	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455000024	motif II; other site
634455000025	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
634455000026	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455000027	Walker A/P-loop; other site
634455000028	ATP binding site [chemical binding]; other site
634455000029	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
634455000030	AAA domain; Region: AAA_12; pfam13087
634455000031	C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118
634455000032	PLD-like domain; Region: PLDc_2; pfam13091
634455000033	putative active site [active]
634455000034	catalytic site [active]
634455000035	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000036	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000037	Domain Homologous to E6-AP Carboxyl Terminus with; Region: HECTc; smart00119
634455000038	Transposase; Region: HTH_Tnp_1; pfam01527
634455000039	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634455000040	HTH-like domain; Region: HTH_21; pfam13276
634455000041	Integrase core domain; Region: rve; pfam00665
634455000042	Integrase core domain; Region: rve_3; pfam13683
634455000043	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
634455000044	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634455000045	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000046	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455000047	DNA binding site [nucleotide binding]
634455000048	Int/Topo IB signature motif; other site
634455000049	active site
634455000050	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
634455000051	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455000052	non-specific DNA binding site [nucleotide binding]; other site
634455000053	salt bridge; other site
634455000054	sequence-specific DNA binding site [nucleotide binding]; other site
634455000055	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634455000056	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634455000057	P-loop; other site
634455000058	Magnesium ion binding site [ion binding]; other site
634455000059	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634455000060	Magnesium ion binding site [ion binding]; other site
634455000061	ParB-like nuclease domain; Region: ParBc; pfam02195
634455000062	KorB domain; Region: KorB; pfam08535
634455000063	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
634455000064	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455000065	S-adenosylmethionine binding site [chemical binding]; other site
634455000066	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
634455000067	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
634455000068	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000069	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634455000070	IHF dimer interface [polypeptide binding]; other site
634455000071	IHF - DNA interface [nucleotide binding]; other site
634455000072	TrwC relaxase; Region: TrwC; pfam08751
634455000073	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000074	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000075	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000076	Transposase domain (DUF772); Region: DUF772; pfam05598
634455000077	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455000078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455000079	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
634455000080	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
634455000081	dimer interface [polypeptide binding]; other site
634455000082	active site
634455000083	metal binding site [ion binding]; metal-binding site
634455000084	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634455000085	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634455000086	NAD(P) binding site [chemical binding]; other site
634455000087	catalytic residues [active]
634455000088	Integrase core domain; Region: rve; pfam00665
634455000089	Winged helix-turn helix; Region: HTH_29; pfam13551
634455000090	Integrase core domain; Region: rve; pfam00665
634455000091	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455000092	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634455000093	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
634455000094	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
634455000095	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634455000096	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
634455000097	Soluble P-type ATPase [General function prediction only]; Region: COG4087
634455000098	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
634455000099	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
634455000100	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
634455000101	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
634455000102	Ligand Binding Site [chemical binding]; other site
634455000103	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
634455000104	GAF domain; Region: GAF_3; pfam13492
634455000105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455000106	dimer interface [polypeptide binding]; other site
634455000107	phosphorylation site [posttranslational modification]
634455000108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455000109	ATP binding site [chemical binding]; other site
634455000110	Mg2+ binding site [ion binding]; other site
634455000111	G-X-G motif; other site
634455000112	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634455000113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455000114	active site
634455000115	phosphorylation site [posttranslational modification]
634455000116	intermolecular recognition site; other site
634455000117	dimerization interface [polypeptide binding]; other site
634455000118	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455000119	DNA binding site [nucleotide binding]
634455000120	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634455000121	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000122	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
634455000123	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634455000124	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
634455000125	Acyltransferase family; Region: Acyl_transf_3; pfam01757
634455000126	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
634455000127	Fic/DOC family; Region: Fic; cl00960
634455000128	Replication protein C N-terminal domain; Region: RP-C; pfam03428
634455000129	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
634455000130	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000131	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455000132	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455000133	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
634455000134	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
634455000135	active site
634455000136	catalytic site [active]
634455000137	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
634455000138	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634455000139	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
634455000140	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634455000141	CrcB-like protein; Region: CRCB; cl09114
634455000142	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000143	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
634455000144	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000145	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000146	Transposase domain (DUF772); Region: DUF772; pfam05598
634455000147	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
634455000148	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
634455000149	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
634455000150	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000151	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455000152	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000153	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455000154	manganese transport protein MntH; Reviewed; Region: PRK00701
634455000155	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
634455000156	manganese transport regulator MntR; Provisional; Region: PRK11050
634455000157	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
634455000158	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
634455000159	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
634455000160	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
634455000161	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
634455000162	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634455000163	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
634455000164	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
634455000165	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
634455000166	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634455000167	iron-sulfur cluster [ion binding]; other site
634455000168	[2Fe-2S] cluster binding site [ion binding]; other site
634455000169	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000170	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
634455000171	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455000172	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455000173	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455000174	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455000175	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000176	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455000177	putative transposase OrfB; Reviewed; Region: PHA02517
634455000178	HTH-like domain; Region: HTH_21; pfam13276
634455000179	Integrase core domain; Region: rve; pfam00665
634455000180	Integrase core domain; Region: rve_3; pfam13683
634455000181	Transposase; Region: HTH_Tnp_1; cl17663
634455000182	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634455000183	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634455000184	Transposase domain (DUF772); Region: DUF772; pfam05598
634455000185	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000186	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634455000187	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
634455000188	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634455000189	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
634455000190	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
634455000191	CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485
634455000192	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
634455000193	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
634455000194	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
634455000195	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
634455000196	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
634455000197	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
634455000198	Winged helix-turn helix; Region: HTH_29; pfam13551
634455000199	Integrase core domain; Region: rve; pfam00665
634455000200	Integrase core domain; Region: rve_3; pfam13683
634455000201	Predicted transcriptional regulator [Transcription]; Region: COG4190
634455000202	Abi-like protein; Region: Abi_2; pfam07751
634455000203	putative transposase OrfB; Reviewed; Region: PHA02517
634455000204	HTH-like domain; Region: HTH_21; pfam13276
634455000205	Integrase core domain; Region: rve; pfam00665
634455000206	Integrase core domain; Region: rve_3; pfam13683
634455000207	Transposase; Region: HTH_Tnp_1; cl17663
634455000208	Predicted membrane protein [Function unknown]; Region: COG3431
634455000209	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000210	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
634455000211	apolar tunnel; other site
634455000212	heme binding site [chemical binding]; other site
634455000213	dimerization interface [polypeptide binding]; other site
634455000214	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
634455000215	Transposase domain (DUF772); Region: DUF772; pfam05598
634455000216	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000217	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634455000218	HTH-like domain; Region: HTH_21; pfam13276
634455000219	Integrase core domain; Region: rve; pfam00665
634455000220	Integrase core domain; Region: rve_3; pfam13683
634455000221	Transposase; Region: HTH_Tnp_1; pfam01527
634455000222	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
634455000223	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
634455000224	Abi-like protein; Region: Abi_2; cl01988
634455000225	myosin-cross-reactive antigen; Provisional; Region: PRK13977
634455000226	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000227	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634455000228	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000229	Transposase domain (DUF772); Region: DUF772; pfam05598
634455000230	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
634455000231	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000232	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455000233	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
634455000234	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
634455000235	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455000236	Transposase domain (DUF772); Region: DUF772; pfam05598
634455000237	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000238	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634455000239	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634455000240	IHF dimer interface [polypeptide binding]; other site
634455000241	IHF - DNA interface [nucleotide binding]; other site
634455000242	putative transposase OrfB; Reviewed; Region: PHA02517
634455000243	HTH-like domain; Region: HTH_21; pfam13276
634455000244	Integrase core domain; Region: rve; pfam00665
634455000245	Integrase core domain; Region: rve_3; pfam13683
634455000246	Transposase; Region: HTH_Tnp_1; cl17663
634455000247	PemK-like protein; Region: PemK; cl00995
634455000248	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
634455000249	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634455000250	oligomeric interface; other site
634455000251	putative active site [active]
634455000252	homodimer interface [polypeptide binding]; other site
634455000253	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
634455000254	Integrase core domain; Region: rve_3; pfam13683
634455000255	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000256	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455000257	DNA-binding interface [nucleotide binding]; DNA binding site
634455000258	hypothetical protein; Provisional; Region: PRK10621
634455000259	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
634455000260	DDE superfamily endonuclease; Region: DDE_5; pfam13546
634455000261	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000262	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455000263	active site
634455000264	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
634455000265	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634455000266	acyl-activating enzyme (AAE) consensus motif; other site
634455000267	AMP binding site [chemical binding]; other site
634455000268	active site
634455000269	CoA binding site [chemical binding]; other site
634455000270	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
634455000271	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634455000272	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
634455000273	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
634455000274	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
634455000275	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
634455000276	dimerization interface [polypeptide binding]; other site
634455000277	putative ATP binding site [chemical binding]; other site
634455000278	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634455000279	Coenzyme A binding pocket [chemical binding]; other site
634455000280	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
634455000281	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455000282	FeS/SAM binding site; other site
634455000283	Predicted amidohydrolase [General function prediction only]; Region: COG0388
634455000284	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
634455000285	putative active site [active]
634455000286	catalytic triad [active]
634455000287	putative dimer interface [polypeptide binding]; other site
634455000288	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
634455000289	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
634455000290	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634455000291	DNA-binding site [nucleotide binding]; DNA binding site
634455000292	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455000293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455000294	homodimer interface [polypeptide binding]; other site
634455000295	catalytic residue [active]
634455000296	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634455000297	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455000298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455000299	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
634455000300	dimerization interface [polypeptide binding]; other site
634455000301	substrate binding pocket [chemical binding]; other site
634455000302	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634455000303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455000304	putative substrate translocation pore; other site
634455000305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455000306	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000307	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000308	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
634455000309	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
634455000310	AAA domain; Region: AAA_30; pfam13604
634455000311	Family description; Region: UvrD_C_2; pfam13538
634455000312	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
634455000313	active site
634455000314	catalytic residues [active]
634455000315	DNA binding site [nucleotide binding]
634455000316	Int/Topo IB signature motif; other site
634455000317	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000318	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455000319	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
634455000320	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
634455000321	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634455000322	active site
634455000323	Int/Topo IB signature motif; other site
634455000324	hypothetical protein; Validated; Region: PRK00124
634455000325	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
634455000326	dimer interface [polypeptide binding]; other site
634455000327	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
634455000328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455000329	putative substrate translocation pore; other site
634455000330	Uncharacterized conserved protein [Function unknown]; Region: COG2835
634455000331	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
634455000332	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
634455000333	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634455000334	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
634455000335	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
634455000336	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
634455000337	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
634455000338	Creatinine amidohydrolase; Region: Creatininase; pfam02633
634455000339	Uncharacterized conserved protein [Function unknown]; Region: COG3391
634455000340	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
634455000341	AAA ATPase domain; Region: AAA_16; pfam13191
634455000342	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
634455000343	Uncharacterized conserved protein [Function unknown]; Region: COG3410
634455000344	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
634455000345	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
634455000346	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
634455000347	putative FMN binding site [chemical binding]; other site
634455000348	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
634455000349	Glycoprotease family; Region: Peptidase_M22; pfam00814
634455000350	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634455000351	Coenzyme A binding pocket [chemical binding]; other site
634455000352	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
634455000353	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
634455000354	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
634455000355	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
634455000356	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
634455000357	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
634455000358	generic binding surface II; other site
634455000359	generic binding surface I; other site
634455000360	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
634455000361	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634455000362	catalytic residue [active]
634455000363	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634455000364	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634455000365	NAD(P) binding site [chemical binding]; other site
634455000366	catalytic residues [active]
634455000367	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634455000368	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
634455000369	NAD binding site [chemical binding]; other site
634455000370	substrate binding site [chemical binding]; other site
634455000371	catalytic Zn binding site [ion binding]; other site
634455000372	tetramer interface [polypeptide binding]; other site
634455000373	structural Zn binding site [ion binding]; other site
634455000374	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
634455000375	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
634455000376	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
634455000377	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
634455000378	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
634455000379	ligand binding site [chemical binding]; other site
634455000380	homodimer interface [polypeptide binding]; other site
634455000381	NAD(P) binding site [chemical binding]; other site
634455000382	trimer interface B [polypeptide binding]; other site
634455000383	trimer interface A [polypeptide binding]; other site
634455000384	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
634455000385	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
634455000386	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
634455000387	Iron-sulfur protein interface; other site
634455000388	proximal quinone binding site [chemical binding]; other site
634455000389	SdhD (CybS) interface [polypeptide binding]; other site
634455000390	proximal heme binding site [chemical binding]; other site
634455000391	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
634455000392	putative SdhC subunit interface [polypeptide binding]; other site
634455000393	putative proximal heme binding site [chemical binding]; other site
634455000394	putative Iron-sulfur protein interface [polypeptide binding]; other site
634455000395	putative proximal quinone binding site; other site
634455000396	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
634455000397	L-aspartate oxidase; Provisional; Region: PRK06175
634455000398	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
634455000399	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
634455000400	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
634455000401	Putative phosphatase (DUF442); Region: DUF442; cl17385
634455000402	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634455000403	EamA-like transporter family; Region: EamA; pfam00892
634455000404	Phosphoglycerate kinase; Region: PGK; pfam00162
634455000405	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
634455000406	substrate binding site [chemical binding]; other site
634455000407	hinge regions; other site
634455000408	ADP binding site [chemical binding]; other site
634455000409	catalytic site [active]
634455000410	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
634455000411	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
634455000412	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
634455000413	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
634455000414	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
634455000415	TPP-binding site [chemical binding]; other site
634455000416	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634455000417	PYR/PP interface [polypeptide binding]; other site
634455000418	dimer interface [polypeptide binding]; other site
634455000419	TPP binding site [chemical binding]; other site
634455000420	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634455000421	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
634455000422	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
634455000423	substrate-cofactor binding pocket; other site
634455000424	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455000425	catalytic residue [active]
634455000426	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
634455000427	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
634455000428	catalytic residues [active]
634455000429	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
634455000430	recombinase A; Provisional; Region: recA; PRK09354
634455000431	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
634455000432	hexamer interface [polypeptide binding]; other site
634455000433	Walker A motif; other site
634455000434	ATP binding site [chemical binding]; other site
634455000435	Walker B motif; other site
634455000436	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
634455000437	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634455000438	Coenzyme A binding pocket [chemical binding]; other site
634455000439	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
634455000440	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
634455000441	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
634455000442	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
634455000443	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
634455000444	Ligand binding site; other site
634455000445	DXD motif; other site
634455000446	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
634455000447	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
634455000448	active site
634455000449	dimer interface [polypeptide binding]; other site
634455000450	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
634455000451	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455000452	putative substrate translocation pore; other site
634455000453	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
634455000454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455000455	Walker A motif; other site
634455000456	ATP binding site [chemical binding]; other site
634455000457	Walker B motif; other site
634455000458	arginine finger; other site
634455000459	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
634455000460	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
634455000461	hypothetical protein; Validated; Region: PRK00153
634455000462	recombination protein RecR; Reviewed; Region: recR; PRK00076
634455000463	RecR protein; Region: RecR; pfam02132
634455000464	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
634455000465	putative active site [active]
634455000466	putative metal-binding site [ion binding]; other site
634455000467	tetramer interface [polypeptide binding]; other site
634455000468	short chain dehydrogenase; Provisional; Region: PRK09134
634455000469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455000470	NAD(P) binding site [chemical binding]; other site
634455000471	active site
634455000472	Dihydroneopterin aldolase; Region: FolB; pfam02152
634455000473	active site
634455000474	TIGR02300 family protein; Region: FYDLN_acid
634455000475	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
634455000476	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
634455000477	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
634455000478	hinge; other site
634455000479	active site
634455000480	cytidylate kinase; Provisional; Region: cmk; PRK00023
634455000481	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
634455000482	CMP-binding site; other site
634455000483	The sites determining sugar specificity; other site
634455000484	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
634455000485	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
634455000486	RNA binding site [nucleotide binding]; other site
634455000487	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
634455000488	RNA binding site [nucleotide binding]; other site
634455000489	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
634455000490	RNA binding site [nucleotide binding]; other site
634455000491	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
634455000492	RNA binding site [nucleotide binding]; other site
634455000493	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
634455000494	RNA binding site [nucleotide binding]; other site
634455000495	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
634455000496	RNA binding site [nucleotide binding]; other site
634455000497	Major royal jelly protein; Region: MRJP; pfam03022
634455000498	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
634455000499	active site
634455000500	dimerization interface [polypeptide binding]; other site
634455000501	ribonuclease PH; Reviewed; Region: rph; PRK00173
634455000502	Ribonuclease PH; Region: RNase_PH_bact; cd11362
634455000503	hexamer interface [polypeptide binding]; other site
634455000504	active site
634455000505	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
634455000506	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
634455000507	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
634455000508	Transglycosylase; Region: Transgly; pfam00912
634455000509	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
634455000510	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
634455000511	This domain is found in peptide chain release factors; Region: PCRF; smart00937
634455000512	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
634455000513	RF-1 domain; Region: RF-1; pfam00472
634455000514	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634455000515	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
634455000516	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634455000517	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634455000518	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634455000519	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634455000520	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
634455000521	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
634455000522	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
634455000523	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
634455000524	rod shape-determining protein MreC; Provisional; Region: PRK13922
634455000525	rod shape-determining protein MreC; Region: MreC; pfam04085
634455000526	rod shape-determining protein MreB; Provisional; Region: PRK13927
634455000527	MreB and similar proteins; Region: MreB_like; cd10225
634455000528	nucleotide binding site [chemical binding]; other site
634455000529	Mg binding site [ion binding]; other site
634455000530	putative protofilament interaction site [polypeptide binding]; other site
634455000531	RodZ interaction site [polypeptide binding]; other site
634455000532	2-isopropylmalate synthase; Validated; Region: PRK00915
634455000533	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
634455000534	active site
634455000535	catalytic residues [active]
634455000536	metal binding site [ion binding]; metal-binding site
634455000537	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
634455000538	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
634455000539	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
634455000540	Uncharacterized conserved protein [Function unknown]; Region: COG0398
634455000541	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
634455000542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455000543	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
634455000544	putative substrate translocation pore; other site
634455000545	PAS fold; Region: PAS_7; pfam12860
634455000546	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634455000547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455000548	dimer interface [polypeptide binding]; other site
634455000549	phosphorylation site [posttranslational modification]
634455000550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455000551	ATP binding site [chemical binding]; other site
634455000552	Mg2+ binding site [ion binding]; other site
634455000553	G-X-G motif; other site
634455000554	Response regulator receiver domain; Region: Response_reg; pfam00072
634455000555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455000556	active site
634455000557	phosphorylation site [posttranslational modification]
634455000558	intermolecular recognition site; other site
634455000559	dimerization interface [polypeptide binding]; other site
634455000560	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634455000561	active site
634455000562	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634455000563	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634455000564	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
634455000565	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
634455000566	MOFRL family; Region: MOFRL; pfam05161
634455000567	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
634455000568	ligand binding site [chemical binding]; other site
634455000569	active site
634455000570	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634455000571	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634455000572	Cytochrome c; Region: Cytochrom_C; pfam00034
634455000573	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
634455000574	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
634455000575	Trp docking motif [polypeptide binding]; other site
634455000576	cytochrome domain interface [polypeptide binding]; other site
634455000577	active site
634455000578	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634455000579	Cytochrome c; Region: Cytochrom_C; pfam00034
634455000580	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
634455000581	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
634455000582	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
634455000583	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
634455000584	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
634455000585	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
634455000586	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
634455000587	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
634455000588	D-pathway; other site
634455000589	Putative ubiquinol binding site [chemical binding]; other site
634455000590	Low-spin heme (heme b) binding site [chemical binding]; other site
634455000591	Putative water exit pathway; other site
634455000592	Binuclear center (heme o3/CuB) [ion binding]; other site
634455000593	K-pathway; other site
634455000594	Putative proton exit pathway; other site
634455000595	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
634455000596	Subunit I/III interface [polypeptide binding]; other site
634455000597	Subunit III/IV interface [polypeptide binding]; other site
634455000598	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
634455000599	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
634455000600	4Fe-4S binding domain; Region: Fer4; pfam00037
634455000601	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
634455000602	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634455000603	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455000604	nucleotide binding region [chemical binding]; other site
634455000605	ATP-binding site [chemical binding]; other site
634455000606	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
634455000607	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
634455000608	interface (dimer of trimers) [polypeptide binding]; other site
634455000609	Substrate-binding/catalytic site; other site
634455000610	Zn-binding sites [ion binding]; other site
634455000611	MarR family; Region: MarR; pfam01047
634455000612	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
634455000613	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
634455000614	Mg++ binding site [ion binding]; other site
634455000615	putative catalytic motif [active]
634455000616	putative substrate binding site [chemical binding]; other site
634455000617	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
634455000618	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
634455000619	NAD(P) binding site [chemical binding]; other site
634455000620	homodimer interface [polypeptide binding]; other site
634455000621	substrate binding site [chemical binding]; other site
634455000622	active site
634455000623	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
634455000624	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
634455000625	inhibitor-cofactor binding pocket; inhibition site
634455000626	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455000627	catalytic residue [active]
634455000628	dihydroorotase; Validated; Region: PRK09060
634455000629	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634455000630	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
634455000631	active site
634455000632	glutathione reductase; Validated; Region: PRK06116
634455000633	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634455000634	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634455000635	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
634455000636	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
634455000637	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
634455000638	FAD binding pocket [chemical binding]; other site
634455000639	FAD binding motif [chemical binding]; other site
634455000640	phosphate binding motif [ion binding]; other site
634455000641	beta-alpha-beta structure motif; other site
634455000642	NAD binding pocket [chemical binding]; other site
634455000643	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634455000644	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455000645	ATP binding site [chemical binding]; other site
634455000646	putative Mg++ binding site [ion binding]; other site
634455000647	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634455000648	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455000649	nucleotide binding region [chemical binding]; other site
634455000650	ATP-binding site [chemical binding]; other site
634455000651	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
634455000652	short chain dehydrogenase; Provisional; Region: PRK06197
634455000653	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455000654	NAD(P) binding site [chemical binding]; other site
634455000655	active site
634455000656	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
634455000657	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
634455000658	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
634455000659	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
634455000660	malate dehydrogenase; Provisional; Region: PRK13529
634455000661	Malic enzyme, N-terminal domain; Region: malic; pfam00390
634455000662	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
634455000663	NAD(P) binding site [chemical binding]; other site
634455000664	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
634455000665	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
634455000666	putative homodimer interface [polypeptide binding]; other site
634455000667	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
634455000668	heterodimer interface [polypeptide binding]; other site
634455000669	homodimer interface [polypeptide binding]; other site
634455000670	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
634455000671	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
634455000672	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
634455000673	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
634455000674	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
634455000675	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
634455000676	beta subunit interaction interface [polypeptide binding]; other site
634455000677	Walker A motif; other site
634455000678	ATP binding site [chemical binding]; other site
634455000679	Walker B motif; other site
634455000680	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
634455000681	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
634455000682	core domain interface [polypeptide binding]; other site
634455000683	delta subunit interface [polypeptide binding]; other site
634455000684	epsilon subunit interface [polypeptide binding]; other site
634455000685	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
634455000686	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
634455000687	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
634455000688	alpha subunit interaction interface [polypeptide binding]; other site
634455000689	Walker A motif; other site
634455000690	ATP binding site [chemical binding]; other site
634455000691	Walker B motif; other site
634455000692	inhibitor binding site; inhibition site
634455000693	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
634455000694	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
634455000695	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
634455000696	gamma subunit interface [polypeptide binding]; other site
634455000697	epsilon subunit interface [polypeptide binding]; other site
634455000698	LBP interface [polypeptide binding]; other site
634455000699	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
634455000700	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
634455000701	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
634455000702	catalytic site [active]
634455000703	putative active site [active]
634455000704	putative substrate binding site [chemical binding]; other site
634455000705	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
634455000706	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
634455000707	substrate binding site [chemical binding]; other site
634455000708	ATP binding site [chemical binding]; other site
634455000709	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
634455000710	GcrA cell cycle regulator; Region: GcrA; cl11564
634455000711	GcrA cell cycle regulator; Region: GcrA; cl11564
634455000712	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
634455000713	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
634455000714	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455000715	Walker A/P-loop; other site
634455000716	ATP binding site [chemical binding]; other site
634455000717	Q-loop/lid; other site
634455000718	ABC transporter signature motif; other site
634455000719	Walker B; other site
634455000720	D-loop; other site
634455000721	H-loop/switch region; other site
634455000722	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
634455000723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455000724	dimer interface [polypeptide binding]; other site
634455000725	conserved gate region; other site
634455000726	putative PBP binding loops; other site
634455000727	ABC-ATPase subunit interface; other site
634455000728	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
634455000729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455000730	dimer interface [polypeptide binding]; other site
634455000731	conserved gate region; other site
634455000732	putative PBP binding loops; other site
634455000733	ABC-ATPase subunit interface; other site
634455000734	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000735	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
634455000736	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
634455000737	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
634455000738	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
634455000739	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
634455000740	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634455000741	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
634455000742	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
634455000743	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
634455000744	ethanolamine permease; Region: 2A0305; TIGR00908
634455000745	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
634455000746	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455000747	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455000748	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
634455000749	Protein export membrane protein; Region: SecD_SecF; cl14618
634455000750	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634455000751	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634455000752	DNA-binding site [nucleotide binding]; DNA binding site
634455000753	RNA-binding motif; other site
634455000754	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455000755	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455000756	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455000757	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634455000758	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455000759	N-terminal plug; other site
634455000760	ligand-binding site [chemical binding]; other site
634455000761	hypothetical protein; Provisional; Region: PRK09945
634455000762	Hint domain; Region: Hint_2; pfam13403
634455000763	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634455000764	formamidase; Provisional; Region: amiF; PRK13287
634455000765	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
634455000766	multimer interface [polypeptide binding]; other site
634455000767	active site
634455000768	catalytic triad [active]
634455000769	dimer interface [polypeptide binding]; other site
634455000770	Response regulator receiver domain; Region: Response_reg; pfam00072
634455000771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455000772	active site
634455000773	phosphorylation site [posttranslational modification]
634455000774	intermolecular recognition site; other site
634455000775	dimerization interface [polypeptide binding]; other site
634455000776	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
634455000777	DNA binding residues [nucleotide binding]
634455000778	dimerization interface [polypeptide binding]; other site
634455000779	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634455000780	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634455000781	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455000782	dimer interface [polypeptide binding]; other site
634455000783	phosphorylation site [posttranslational modification]
634455000784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455000785	ATP binding site [chemical binding]; other site
634455000786	Mg2+ binding site [ion binding]; other site
634455000787	G-X-G motif; other site
634455000788	Response regulator receiver domain; Region: Response_reg; pfam00072
634455000789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455000790	active site
634455000791	phosphorylation site [posttranslational modification]
634455000792	intermolecular recognition site; other site
634455000793	dimerization interface [polypeptide binding]; other site
634455000794	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
634455000795	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
634455000796	putative ligand binding site [chemical binding]; other site
634455000797	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
634455000798	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
634455000799	TM-ABC transporter signature motif; other site
634455000800	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
634455000801	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
634455000802	TM-ABC transporter signature motif; other site
634455000803	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
634455000804	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
634455000805	Walker A/P-loop; other site
634455000806	ATP binding site [chemical binding]; other site
634455000807	Q-loop/lid; other site
634455000808	ABC transporter signature motif; other site
634455000809	Walker B; other site
634455000810	D-loop; other site
634455000811	H-loop/switch region; other site
634455000812	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
634455000813	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
634455000814	Walker A/P-loop; other site
634455000815	ATP binding site [chemical binding]; other site
634455000816	Q-loop/lid; other site
634455000817	ABC transporter signature motif; other site
634455000818	Walker B; other site
634455000819	D-loop; other site
634455000820	H-loop/switch region; other site
634455000821	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455000822	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
634455000823	Predicted transcriptional regulator [Transcription]; Region: COG2378
634455000824	WYL domain; Region: WYL; pfam13280
634455000825	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455000826	active site
634455000827	Int/Topo IB signature motif; other site
634455000828	DNA binding site [nucleotide binding]
634455000829	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000830	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
634455000831	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455000832	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
634455000833	active site
634455000834	Catalytic domain of Protein Kinases; Region: PKc; cd00180
634455000835	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
634455000836	active site
634455000837	ATP binding site [chemical binding]; other site
634455000838	substrate binding site [chemical binding]; other site
634455000839	activation loop (A-loop); other site
634455000840	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
634455000841	Catalytic domain of Protein Kinases; Region: PKc; cd00180
634455000842	active site
634455000843	ATP binding site [chemical binding]; other site
634455000844	substrate binding site [chemical binding]; other site
634455000845	activation loop (A-loop); other site
634455000846	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455000847	active site
634455000848	Int/Topo IB signature motif; other site
634455000849	DNA binding site [nucleotide binding]
634455000850	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634455000851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455000852	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634455000853	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634455000854	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634455000855	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634455000856	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455000857	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634455000858	Transposase; Region: HTH_Tnp_1; pfam01527
634455000859	Protein of unknown function DUF45; Region: DUF45; pfam01863
634455000860	hypothetical protein; Provisional; Region: PRK05170
634455000861	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
634455000862	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
634455000863	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455000864	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
634455000865	Walker A/P-loop; other site
634455000866	ATP binding site [chemical binding]; other site
634455000867	Q-loop/lid; other site
634455000868	ABC transporter signature motif; other site
634455000869	Walker B; other site
634455000870	D-loop; other site
634455000871	H-loop/switch region; other site
634455000872	TOBE domain; Region: TOBE_2; pfam08402
634455000873	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
634455000874	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
634455000875	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634455000876	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
634455000877	multidrug resistance protein MdtN; Provisional; Region: PRK10476
634455000878	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455000879	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455000880	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634455000881	hopanoid-associated phosphorylase; Region: HpnG; TIGR03468
634455000882	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
634455000883	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
634455000884	Active site cavity [active]
634455000885	catalytic acid [active]
634455000886	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
634455000887	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
634455000888	active site lid residues [active]
634455000889	substrate binding pocket [chemical binding]; other site
634455000890	catalytic residues [active]
634455000891	substrate-Mg2+ binding site; other site
634455000892	aspartate-rich region 1; other site
634455000893	aspartate-rich region 2; other site
634455000894	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
634455000895	active site lid residues [active]
634455000896	substrate binding pocket [chemical binding]; other site
634455000897	catalytic residues [active]
634455000898	substrate-Mg2+ binding site; other site
634455000899	aspartate-rich region 1; other site
634455000900	aspartate-rich region 2; other site
634455000901	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
634455000902	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634455000903	active site
634455000904	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634455000905	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
634455000906	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
634455000907	putative NADP binding site [chemical binding]; other site
634455000908	putative substrate binding site [chemical binding]; other site
634455000909	active site
634455000910	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
634455000911	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
634455000912	prephenate dehydrogenase; Validated; Region: PRK08507
634455000913	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634455000914	TPR motif; other site
634455000915	TPR repeat; Region: TPR_11; pfam13414
634455000916	binding surface
634455000917	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455000918	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455000919	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
634455000920	dimerization interface [polypeptide binding]; other site
634455000921	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
634455000922	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
634455000923	dimer interface [polypeptide binding]; other site
634455000924	decamer (pentamer of dimers) interface [polypeptide binding]; other site
634455000925	catalytic triad [active]
634455000926	peroxidatic and resolving cysteines [active]
634455000927	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
634455000928	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
634455000929	Uncharacterized conserved protein [Function unknown]; Region: COG2353
634455000930	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
634455000931	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
634455000932	putative active site [active]
634455000933	metal binding site [ion binding]; metal-binding site
634455000934	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
634455000935	dimer interface [polypeptide binding]; other site
634455000936	substrate binding site [chemical binding]; other site
634455000937	metal binding sites [ion binding]; metal-binding site
634455000938	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
634455000939	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455000940	Walker A/P-loop; other site
634455000941	ATP binding site [chemical binding]; other site
634455000942	Q-loop/lid; other site
634455000943	ABC transporter signature motif; other site
634455000944	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634455000945	ABC transporter; Region: ABC_tran_2; pfam12848
634455000946	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634455000947	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
634455000948	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
634455000949	Coenzyme A binding pocket [chemical binding]; other site
634455000950	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
634455000951	VacJ like lipoprotein; Region: VacJ; cl01073
634455000952	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
634455000953	putative metal binding site [ion binding]; other site
634455000954	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
634455000955	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634455000956	HSP70 interaction site [polypeptide binding]; other site
634455000957	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
634455000958	epoxyqueuosine reductase; Region: TIGR00276
634455000959	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
634455000960	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
634455000961	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
634455000962	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
634455000963	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
634455000964	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
634455000965	substrate binding site [chemical binding]; other site
634455000966	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
634455000967	FAD binding site [chemical binding]; other site
634455000968	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
634455000969	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
634455000970	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
634455000971	homodimer interface [polypeptide binding]; other site
634455000972	NADP binding site [chemical binding]; other site
634455000973	substrate binding site [chemical binding]; other site
634455000974	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
634455000975	Protein of unknown function, DUF482; Region: DUF482; pfam04339
634455000976	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
634455000977	homotrimer interaction site [polypeptide binding]; other site
634455000978	putative active site [active]
634455000979	TSCPD domain; Region: TSCPD; pfam12637
634455000980	NADH dehydrogenase; Validated; Region: PRK08183
634455000981	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
634455000982	mce related protein; Region: MCE; pfam02470
634455000983	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
634455000984	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455000985	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
634455000986	active site
634455000987	motif I; other site
634455000988	motif II; other site
634455000989	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
634455000990	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
634455000991	active site
634455000992	homotetramer interface [polypeptide binding]; other site
634455000993	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
634455000994	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634455000995	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
634455000996	Probable Catalytic site; other site
634455000997	metal-binding site
634455000998	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455000999	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
634455001000	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
634455001001	nudix motif; other site
634455001002	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634455001003	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
634455001004	active site
634455001005	catalytic tetrad [active]
634455001006	Helix-turn-helix domain; Region: HTH_17; pfam12728
634455001007	excinuclease ABC subunit B; Provisional; Region: PRK05298
634455001008	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455001009	ATP binding site [chemical binding]; other site
634455001010	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455001011	nucleotide binding region [chemical binding]; other site
634455001012	ATP-binding site [chemical binding]; other site
634455001013	Ultra-violet resistance protein B; Region: UvrB; pfam12344
634455001014	UvrB/uvrC motif; Region: UVR; pfam02151
634455001015	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
634455001016	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634455001017	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
634455001018	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634455001019	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634455001020	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634455001021	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
634455001022	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455001023	active site
634455001024	motif I; other site
634455001025	motif II; other site
634455001026	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634455001027	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
634455001028	active site
634455001029	L-asparagine permease; Provisional; Region: PRK15049
634455001030	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
634455001031	active site
634455001032	DNA polymerase IV; Validated; Region: PRK02406
634455001033	DNA binding site [nucleotide binding]
634455001034	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
634455001035	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
634455001036	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
634455001037	quinone interaction residues [chemical binding]; other site
634455001038	active site
634455001039	catalytic residues [active]
634455001040	FMN binding site [chemical binding]; other site
634455001041	substrate binding site [chemical binding]; other site
634455001042	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
634455001043	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455001044	active site
634455001045	motif I; other site
634455001046	motif II; other site
634455001047	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455001048	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
634455001049	nudix motif; other site
634455001050	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
634455001051	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
634455001052	putative active site [active]
634455001053	metal binding site [ion binding]; metal-binding site
634455001054	homodimer binding site [polypeptide binding]; other site
634455001055	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
634455001056	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
634455001057	Cell division protein ZapA; Region: ZapA; cl01146
634455001058	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
634455001059	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
634455001060	putative active site; other site
634455001061	catalytic residue [active]
634455001062	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
634455001063	thiamine phosphate binding site [chemical binding]; other site
634455001064	active site
634455001065	pyrophosphate binding site [ion binding]; other site
634455001066	Prophage antirepressor [Transcription]; Region: COG3617
634455001067	BRO family, N-terminal domain; Region: Bro-N; smart01040
634455001068	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
634455001069	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
634455001070	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
634455001071	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455001072	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
634455001073	Transposase; Region: DDE_Tnp_ISL3; pfam01610
634455001074	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455001075	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455001076	Transposase; Region: DDE_Tnp_ISL3; pfam01610
634455001077	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634455001078	Fasciclin domain; Region: Fasciclin; cl02663
634455001079	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634455001080	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
634455001081	motif 1; other site
634455001082	dimer interface [polypeptide binding]; other site
634455001083	active site
634455001084	motif 2; other site
634455001085	motif 3; other site
634455001086	Radical SAM superfamily; Region: Radical_SAM; pfam04055
634455001087	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455001088	FeS/SAM binding site; other site
634455001089	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
634455001090	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
634455001091	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
634455001092	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
634455001093	active site
634455001094	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
634455001095	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
634455001096	Uncharacterized conserved protein [Function unknown]; Region: COG2127
634455001097	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
634455001098	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455001099	Walker A motif; other site
634455001100	ATP binding site [chemical binding]; other site
634455001101	Walker B motif; other site
634455001102	arginine finger; other site
634455001103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455001104	Walker A motif; other site
634455001105	ATP binding site [chemical binding]; other site
634455001106	Walker B motif; other site
634455001107	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
634455001108	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
634455001109	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
634455001110	Putative transcriptional regulator [Transcription]; Region: COG1678
634455001111	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
634455001112	Shikimate kinase; Region: SKI; pfam01202
634455001113	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
634455001114	homotrimer interaction site [polypeptide binding]; other site
634455001115	putative active site [active]
634455001116	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
634455001117	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
634455001118	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634455001119	HAMP domain; Region: HAMP; pfam00672
634455001120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455001121	dimer interface [polypeptide binding]; other site
634455001122	phosphorylation site [posttranslational modification]
634455001123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455001124	ATP binding site [chemical binding]; other site
634455001125	Mg2+ binding site [ion binding]; other site
634455001126	G-X-G motif; other site
634455001127	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634455001128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455001129	active site
634455001130	phosphorylation site [posttranslational modification]
634455001131	intermolecular recognition site; other site
634455001132	dimerization interface [polypeptide binding]; other site
634455001133	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455001134	DNA binding site [nucleotide binding]
634455001135	GrpE; Region: GrpE; pfam01025
634455001136	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
634455001137	dimer interface [polypeptide binding]; other site
634455001138	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
634455001139	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
634455001140	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
634455001141	nucleotide binding site [chemical binding]; other site
634455001142	NEF interaction site [polypeptide binding]; other site
634455001143	SBD interface [polypeptide binding]; other site
634455001144	chaperone protein DnaJ; Provisional; Region: PRK10767
634455001145	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634455001146	HSP70 interaction site [polypeptide binding]; other site
634455001147	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
634455001148	Zn binding sites [ion binding]; other site
634455001149	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
634455001150	dimer interface [polypeptide binding]; other site
634455001151	dihydrodipicolinate reductase; Provisional; Region: PRK00048
634455001152	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
634455001153	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
634455001154	S-adenosylmethionine synthetase; Validated; Region: PRK05250
634455001155	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
634455001156	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
634455001157	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
634455001158	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
634455001159	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
634455001160	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
634455001161	purine monophosphate binding site [chemical binding]; other site
634455001162	dimer interface [polypeptide binding]; other site
634455001163	putative catalytic residues [active]
634455001164	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
634455001165	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634455001166	EamA-like transporter family; Region: EamA; pfam00892
634455001167	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
634455001168	DALR anticodon binding domain; Region: DALR_1; pfam05746
634455001169	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
634455001170	dimer interface [polypeptide binding]; other site
634455001171	motif 1; other site
634455001172	active site
634455001173	motif 2; other site
634455001174	motif 3; other site
634455001175	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
634455001176	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634455001177	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455001178	non-specific DNA binding site [nucleotide binding]; other site
634455001179	salt bridge; other site
634455001180	sequence-specific DNA binding site [nucleotide binding]; other site
634455001181	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
634455001182	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
634455001183	putative active site [active]
634455001184	catalytic triad [active]
634455001185	putative dimer interface [polypeptide binding]; other site
634455001186	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
634455001187	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
634455001188	metal binding site 2 [ion binding]; metal-binding site
634455001189	putative DNA binding helix; other site
634455001190	metal binding site 1 [ion binding]; metal-binding site
634455001191	dimer interface [polypeptide binding]; other site
634455001192	structural Zn2+ binding site [ion binding]; other site
634455001193	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
634455001194	CPxP  motif; other site
634455001195	transcription termination factor Rho; Provisional; Region: rho; PRK09376
634455001196	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
634455001197	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
634455001198	RNA binding site [nucleotide binding]; other site
634455001199	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
634455001200	multimer interface [polypeptide binding]; other site
634455001201	Walker A motif; other site
634455001202	ATP binding site [chemical binding]; other site
634455001203	Walker B motif; other site
634455001204	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
634455001205	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
634455001206	oligomer interface [polypeptide binding]; other site
634455001207	Cl binding site [ion binding]; other site
634455001208	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
634455001209	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
634455001210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455001211	catalytic residue [active]
634455001212	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
634455001213	substrate binding site [chemical binding]; other site
634455001214	active site
634455001215	catalytic residues [active]
634455001216	heterodimer interface [polypeptide binding]; other site
634455001217	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
634455001218	HerA helicase [Replication, recombination, and repair]; Region: COG0433
634455001219	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634455001220	Walker A motif; other site
634455001221	ATP binding site [chemical binding]; other site
634455001222	Walker B motif; other site
634455001223	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
634455001224	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
634455001225	dimer interface [polypeptide binding]; other site
634455001226	motif 1; other site
634455001227	active site
634455001228	motif 2; other site
634455001229	motif 3; other site
634455001230	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
634455001231	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
634455001232	GDP-binding site [chemical binding]; other site
634455001233	ACT binding site; other site
634455001234	IMP binding site; other site
634455001235	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
634455001236	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455001237	active site
634455001238	phosphorylation site [posttranslational modification]
634455001239	intermolecular recognition site; other site
634455001240	dimerization interface [polypeptide binding]; other site
634455001241	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455001242	DNA binding site [nucleotide binding]
634455001243	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
634455001244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455001245	dimer interface [polypeptide binding]; other site
634455001246	phosphorylation site [posttranslational modification]
634455001247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455001248	ATP binding site [chemical binding]; other site
634455001249	Mg2+ binding site [ion binding]; other site
634455001250	G-X-G motif; other site
634455001251	PBP superfamily domain; Region: PBP_like_2; cl17296
634455001252	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
634455001253	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
634455001254	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634455001255	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
634455001256	catalytic core [active]
634455001257	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
634455001258	Domain of unknown function DUF21; Region: DUF21; pfam01595
634455001259	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634455001260	Transporter associated domain; Region: CorC_HlyC; smart01091
634455001261	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
634455001262	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
634455001263	NADP binding site [chemical binding]; other site
634455001264	dimer interface [polypeptide binding]; other site
634455001265	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
634455001266	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
634455001267	putative active site [active]
634455001268	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634455001269	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
634455001270	Walker A/P-loop; other site
634455001271	ATP binding site [chemical binding]; other site
634455001272	Q-loop/lid; other site
634455001273	ABC transporter signature motif; other site
634455001274	Walker B; other site
634455001275	D-loop; other site
634455001276	H-loop/switch region; other site
634455001277	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
634455001278	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455001279	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455001280	Hint domain; Region: Hint_2; pfam13403
634455001281	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
634455001282	classical (c) SDRs; Region: SDR_c; cd05233
634455001283	NAD(P) binding site [chemical binding]; other site
634455001284	active site
634455001285	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
634455001286	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
634455001287	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
634455001288	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
634455001289	homodimer interface [polypeptide binding]; other site
634455001290	metal binding site [ion binding]; metal-binding site
634455001291	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
634455001292	homodimer interface [polypeptide binding]; other site
634455001293	active site
634455001294	putative chemical substrate binding site [chemical binding]; other site
634455001295	metal binding site [ion binding]; metal-binding site
634455001296	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634455001297	heat shock protein 90; Provisional; Region: PRK05218
634455001298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455001299	ATP binding site [chemical binding]; other site
634455001300	Mg2+ binding site [ion binding]; other site
634455001301	G-X-G motif; other site
634455001302	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
634455001303	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455001304	DNA binding site [nucleotide binding]
634455001305	active site
634455001306	Int/Topo IB signature motif; other site
634455001307	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
634455001308	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455001309	CotH protein; Region: CotH; pfam08757
634455001310	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
634455001311	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
634455001312	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
634455001313	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
634455001314	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
634455001315	active site
634455001316	substrate binding site [chemical binding]; other site
634455001317	Mg2+ binding site [ion binding]; other site
634455001318	hypothetical protein; Provisional; Region: PRK09272
634455001319	hypothetical protein; Provisional; Region: PRK10316
634455001320	YfdX protein; Region: YfdX; pfam10938
634455001321	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634455001322	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455001323	sequence-specific DNA binding site [nucleotide binding]; other site
634455001324	salt bridge; other site
634455001325	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
634455001326	Domain of unknown function (DUF955); Region: DUF955; pfam06114
634455001327	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
634455001328	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
634455001329	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
634455001330	methylcitrate synthase; Provisional; Region: PRK12351
634455001331	oxalacetate binding site [chemical binding]; other site
634455001332	citrylCoA binding site [chemical binding]; other site
634455001333	coenzyme A binding site [chemical binding]; other site
634455001334	catalytic triad [active]
634455001335	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
634455001336	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
634455001337	tetramer interface [polypeptide binding]; other site
634455001338	active site
634455001339	Mg2+/Mn2+ binding site [ion binding]; other site
634455001340	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634455001341	acetyl-CoA synthetase; Provisional; Region: PRK00174
634455001342	acyl-activating enzyme (AAE) consensus motif; other site
634455001343	AMP binding site [chemical binding]; other site
634455001344	active site
634455001345	CoA binding site [chemical binding]; other site
634455001346	putative sialic acid transporter; Region: 2A0112; TIGR00891
634455001347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455001348	putative substrate translocation pore; other site
634455001349	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
634455001350	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
634455001351	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
634455001352	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
634455001353	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
634455001354	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
634455001355	dimer interface [polypeptide binding]; other site
634455001356	anticodon binding site; other site
634455001357	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
634455001358	homodimer interface [polypeptide binding]; other site
634455001359	motif 1; other site
634455001360	active site
634455001361	motif 2; other site
634455001362	GAD domain; Region: GAD; pfam02938
634455001363	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634455001364	active site
634455001365	motif 3; other site
634455001366	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
634455001367	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
634455001368	tetramer interface [polypeptide binding]; other site
634455001369	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455001370	catalytic residue [active]
634455001371	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
634455001372	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
634455001373	5S rRNA interface [nucleotide binding]; other site
634455001374	CTC domain interface [polypeptide binding]; other site
634455001375	L16 interface [polypeptide binding]; other site
634455001376	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
634455001377	putative active site [active]
634455001378	catalytic residue [active]
634455001379	GTP-binding protein YchF; Reviewed; Region: PRK09601
634455001380	YchF GTPase; Region: YchF; cd01900
634455001381	G1 box; other site
634455001382	GTP/Mg2+ binding site [chemical binding]; other site
634455001383	Switch I region; other site
634455001384	G2 box; other site
634455001385	Switch II region; other site
634455001386	G3 box; other site
634455001387	G4 box; other site
634455001388	G5 box; other site
634455001389	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
634455001390	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
634455001391	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
634455001392	putative catalytic cysteine [active]
634455001393	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
634455001394	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
634455001395	active site
634455001396	(T/H)XGH motif; other site
634455001397	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
634455001398	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
634455001399	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
634455001400	Rhodanese-like domain; Region: Rhodanese; pfam00581
634455001401	active site residue [active]
634455001402	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
634455001403	active site residue [active]
634455001404	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455001405	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455001406	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
634455001407	putative dimerization interface [polypeptide binding]; other site
634455001408	putative substrate binding pocket [chemical binding]; other site
634455001409	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
634455001410	acetolactate synthase; Reviewed; Region: PRK08617
634455001411	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634455001412	PYR/PP interface [polypeptide binding]; other site
634455001413	dimer interface [polypeptide binding]; other site
634455001414	TPP binding site [chemical binding]; other site
634455001415	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634455001416	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
634455001417	TPP-binding site [chemical binding]; other site
634455001418	benzoylformate decarboxylase; Reviewed; Region: PRK07092
634455001419	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634455001420	PYR/PP interface [polypeptide binding]; other site
634455001421	dimer interface [polypeptide binding]; other site
634455001422	TPP binding site [chemical binding]; other site
634455001423	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634455001424	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
634455001425	TPP-binding site [chemical binding]; other site
634455001426	dimer interface [polypeptide binding]; other site
634455001427	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
634455001428	Cysteine-rich domain; Region: CCG; pfam02754
634455001429	Cysteine-rich domain; Region: CCG; pfam02754
634455001430	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
634455001431	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
634455001432	4Fe-4S binding domain; Region: Fer4; pfam00037
634455001433	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
634455001434	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
634455001435	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
634455001436	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
634455001437	hinge; other site
634455001438	active site
634455001439	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
634455001440	trimer interface [polypeptide binding]; other site
634455001441	active site
634455001442	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634455001443	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
634455001444	putative active site [active]
634455001445	YdjC motif; other site
634455001446	Mg binding site [ion binding]; other site
634455001447	putative homodimer interface [polypeptide binding]; other site
634455001448	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
634455001449	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
634455001450	B12 binding site [chemical binding]; other site
634455001451	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455001452	FeS/SAM binding site; other site
634455001453	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
634455001454	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
634455001455	ligand binding site; other site
634455001456	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
634455001457	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
634455001458	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
634455001459	TPP-binding site; other site
634455001460	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634455001461	PYR/PP interface [polypeptide binding]; other site
634455001462	dimer interface [polypeptide binding]; other site
634455001463	TPP binding site [chemical binding]; other site
634455001464	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634455001465	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
634455001466	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455001467	FeS/SAM binding site; other site
634455001468	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
634455001469	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
634455001470	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
634455001471	Domain of unknown function DUF21; Region: DUF21; pfam01595
634455001472	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634455001473	Transporter associated domain; Region: CorC_HlyC; smart01091
634455001474	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634455001475	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634455001476	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634455001477	catalytic residue [active]
634455001478	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
634455001479	Fe-S cluster binding site [ion binding]; other site
634455001480	active site
634455001481	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
634455001482	binding surface
634455001483	TPR motif; other site
634455001484	Tetratricopeptide repeat; Region: TPR_12; pfam13424
634455001485	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634455001486	TPR motif; other site
634455001487	TPR repeat; Region: TPR_11; pfam13414
634455001488	binding surface
634455001489	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
634455001490	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455001491	NAD(P) binding site [chemical binding]; other site
634455001492	active site
634455001493	Predicted membrane protein [Function unknown]; Region: COG1238
634455001494	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
634455001495	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
634455001496	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
634455001497	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
634455001498	Walker A/P-loop; other site
634455001499	ATP binding site [chemical binding]; other site
634455001500	Q-loop/lid; other site
634455001501	ABC transporter signature motif; other site
634455001502	Walker B; other site
634455001503	D-loop; other site
634455001504	H-loop/switch region; other site
634455001505	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
634455001506	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
634455001507	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
634455001508	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
634455001509	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634455001510	active site
634455001511	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634455001512	catalytic core [active]
634455001513	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
634455001514	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455001515	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455001516	short chain dehydrogenase; Provisional; Region: PRK12744
634455001517	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455001518	NAD(P) binding site [chemical binding]; other site
634455001519	active site
634455001520	transcriptional regulator; Provisional; Region: PRK10632
634455001521	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455001522	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
634455001523	putative effector binding pocket; other site
634455001524	putative dimerization interface [polypeptide binding]; other site
634455001525	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634455001526	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
634455001527	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
634455001528	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455001529	N-terminal plug; other site
634455001530	ligand-binding site [chemical binding]; other site
634455001531	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634455001532	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
634455001533	intersubunit interface [polypeptide binding]; other site
634455001534	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
634455001535	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
634455001536	putative PBP binding regions; other site
634455001537	ABC-ATPase subunit  interface; other site
634455001538	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
634455001539	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
634455001540	Walker A/P-loop; other site
634455001541	ATP binding site [chemical binding]; other site
634455001542	Q-loop/lid; other site
634455001543	ABC transporter signature motif; other site
634455001544	Walker B; other site
634455001545	D-loop; other site
634455001546	H-loop/switch region; other site
634455001547	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
634455001548	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
634455001549	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
634455001550	active site
634455001551	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634455001552	nucleotide binding site [chemical binding]; other site
634455001553	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
634455001554	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
634455001555	putative active site [active]
634455001556	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
634455001557	Na binding site [ion binding]; other site
634455001558	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634455001559	long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584
634455001560	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455001561	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455001562	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455001563	Hint domain; Region: Hint_2; pfam13403
634455001564	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
634455001565	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
634455001566	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
634455001567	DNA binding residues [nucleotide binding]
634455001568	dimerization interface [polypeptide binding]; other site
634455001569	Hint domain; Region: Hint_2; pfam13403
634455001570	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
634455001571	DNA photolyase; Region: DNA_photolyase; pfam00875
634455001572	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
634455001573	SelR domain; Region: SelR; pfam01641
634455001574	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
634455001575	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634455001576	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634455001577	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
634455001578	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455001579	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455001580	homodimer interface [polypeptide binding]; other site
634455001581	catalytic residue [active]
634455001582	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455001583	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455001584	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455001585	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455001586	Hint domain; Region: Hint_2; pfam13403
634455001587	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
634455001588	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
634455001589	dimerization interface [polypeptide binding]; other site
634455001590	DPS ferroxidase diiron center [ion binding]; other site
634455001591	ion pore; other site
634455001592	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
634455001593	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
634455001594	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
634455001595	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
634455001596	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
634455001597	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
634455001598	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455001599	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455001600	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634455001601	dimerization interface [polypeptide binding]; other site
634455001602	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
634455001603	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
634455001604	Methylamine utilisation protein MauE; Region: MauE; pfam07291
634455001605	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634455001606	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
634455001607	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
634455001608	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634455001609	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634455001610	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634455001611	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
634455001612	active site
634455001613	catalytic tetrad [active]
634455001614	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455001615	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455001616	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634455001617	dimerization interface [polypeptide binding]; other site
634455001618	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
634455001619	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634455001620	NAD binding site [chemical binding]; other site
634455001621	catalytic residues [active]
634455001622	substrate binding site [chemical binding]; other site
634455001623	Cytochrome c; Region: Cytochrom_C; cl11414
634455001624	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634455001625	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634455001626	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634455001627	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
634455001628	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634455001629	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634455001630	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634455001631	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
634455001632	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634455001633	catalytic loop [active]
634455001634	iron binding site [ion binding]; other site
634455001635	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634455001636	Protein of unknown function (DUF563); Region: DUF563; pfam04577
634455001637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455001638	S-adenosylmethionine binding site [chemical binding]; other site
634455001639	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
634455001640	Hint domain; Region: Hint_2; pfam13403
634455001641	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455001642	putative substrate translocation pore; other site
634455001643	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634455001644	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
634455001645	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455001646	Predicted integral membrane protein [Function unknown]; Region: COG0762
634455001647	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634455001648	Protein of unknown function (DUF805); Region: DUF805; pfam05656
634455001649	CHRD domain; Region: CHRD; pfam07452
634455001650	Predicted membrane protein [Function unknown]; Region: COG3650
634455001651	META domain; Region: META; pfam03724
634455001652	Hint domain; Region: Hint_2; pfam13403
634455001653	T5orf172 domain; Region: T5orf172; pfam10544
634455001654	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
634455001655	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634455001656	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455001657	N-terminal plug; other site
634455001658	ligand-binding site [chemical binding]; other site
634455001659	Cytochrome c; Region: Cytochrom_C; pfam00034
634455001660	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
634455001661	FAD dependent oxidoreductase; Region: DAO; pfam01266
634455001662	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455001663	NmrA-like family; Region: NmrA; pfam05368
634455001664	NAD(P) binding site [chemical binding]; other site
634455001665	active site
634455001666	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
634455001667	Hint domain; Region: Hint_2; pfam13403
634455001668	Hint domain; Region: Hint_2; pfam13403
634455001669	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
634455001670	Hint domain; Region: Hint_2; pfam13403
634455001671	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455001672	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634455001673	non-specific DNA binding site [nucleotide binding]; other site
634455001674	salt bridge; other site
634455001675	sequence-specific DNA binding site [nucleotide binding]; other site
634455001676	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634455001677	Catalytic site [active]
634455001678	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
634455001679	Hint domain; Region: Hint_2; pfam13403
634455001680	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634455001681	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634455001682	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455001683	DNA-binding interface [nucleotide binding]; DNA binding site
634455001684	Hint domain; Region: Hint_2; pfam13403
634455001685	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
634455001686	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
634455001687	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455001688	FeS/SAM binding site; other site
634455001689	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
634455001690	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
634455001691	Terminase-like family; Region: Terminase_6; pfam03237
634455001692	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
634455001693	hypothetical protein; Validated; Region: PRK01415
634455001694	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
634455001695	active site residue [active]
634455001696	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
634455001697	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
634455001698	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
634455001699	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
634455001700	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
634455001701	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
634455001702	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
634455001703	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455001704	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
634455001705	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
634455001706	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634455001707	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455001708	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455001709	Phosphotransferase enzyme family; Region: APH; pfam01636
634455001710	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
634455001711	substrate binding site [chemical binding]; other site
634455001712	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
634455001713	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
634455001714	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
634455001715	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
634455001716	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
634455001717	putative active site [active]
634455001718	putative substrate binding site [chemical binding]; other site
634455001719	putative cosubstrate binding site; other site
634455001720	catalytic site [active]
634455001721	Uncharacterized conserved protein [Function unknown]; Region: COG3189
634455001722	Predicted transcriptional regulator [Transcription]; Region: COG1959
634455001723	Transcriptional regulator; Region: Rrf2; cl17282
634455001724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455001725	malonic semialdehyde reductase; Provisional; Region: PRK10538
634455001726	NAD(P) binding site [chemical binding]; other site
634455001727	active site
634455001728	CrcB-like protein; Region: CRCB; cl09114
634455001729	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
634455001730	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634455001731	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
634455001732	dinuclear metal binding motif [ion binding]; other site
634455001733	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
634455001734	Hint domain; Region: Hint_2; pfam13403
634455001735	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634455001736	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634455001737	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
634455001738	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
634455001739	active site
634455001740	Zn binding site [ion binding]; other site
634455001741	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455001742	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455001743	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455001744	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455001745	Coenzyme A transferase; Region: CoA_trans; smart00882
634455001746	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455001747	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455001748	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455001749	Coenzyme A transferase; Region: CoA_trans; cl17247
634455001750	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
634455001751	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
634455001752	MOFRL family; Region: MOFRL; pfam05161
634455001753	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634455001754	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634455001755	active site
634455001756	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
634455001757	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455001758	NAD(P) binding site [chemical binding]; other site
634455001759	active site
634455001760	Protein of unknown function (DUF993); Region: DUF993; pfam06187
634455001761	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
634455001762	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
634455001763	DNA interaction; other site
634455001764	Metal-binding active site; metal-binding site
634455001765	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
634455001766	Electron transfer flavoprotein domain; Region: ETF; pfam01012
634455001767	Ligand binding site [chemical binding]; other site
634455001768	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455001769	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455001770	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455001771	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
634455001772	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
634455001773	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
634455001774	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634455001775	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
634455001776	NAD(P) binding site [chemical binding]; other site
634455001777	catalytic residues [active]
634455001778	choline dehydrogenase; Validated; Region: PRK02106
634455001779	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634455001780	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
634455001781	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455001782	putative substrate translocation pore; other site
634455001783	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634455001784	Hint domain; Region: Hint_2; pfam13403
634455001785	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455001786	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455001787	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455001788	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455001789	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
634455001790	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
634455001791	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
634455001792	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
634455001793	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
634455001794	tetramer interface [polypeptide binding]; other site
634455001795	TPP-binding site [chemical binding]; other site
634455001796	heterodimer interface [polypeptide binding]; other site
634455001797	phosphorylation loop region [posttranslational modification]
634455001798	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
634455001799	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
634455001800	alpha subunit interface [polypeptide binding]; other site
634455001801	TPP binding site [chemical binding]; other site
634455001802	heterodimer interface [polypeptide binding]; other site
634455001803	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634455001804	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
634455001805	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634455001806	E3 interaction surface; other site
634455001807	lipoyl attachment site [posttranslational modification]; other site
634455001808	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
634455001809	catalytic site [active]
634455001810	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634455001811	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
634455001812	putative dimer interface [polypeptide binding]; other site
634455001813	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
634455001814	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634455001815	FOG: WD40 repeat [General function prediction only]; Region: COG2319
634455001816	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
634455001817	structural tetrad; other site
634455001818	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
634455001819	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
634455001820	P-loop, Walker A motif; other site
634455001821	Base recognition motif; other site
634455001822	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
634455001823	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
634455001824	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
634455001825	putative ion selectivity filter; other site
634455001826	putative pore gating glutamate residue; other site
634455001827	putative H+/Cl- coupling transport residue; other site
634455001828	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
634455001829	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
634455001830	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
634455001831	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
634455001832	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634455001833	acyl-CoA esterase; Provisional; Region: PRK10673
634455001834	PGAP1-like protein; Region: PGAP1; pfam07819
634455001835	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634455001836	Ligand Binding Site [chemical binding]; other site
634455001837	Predicted membrane protein [Function unknown]; Region: COG1297
634455001838	putative oligopeptide transporter, OPT family; Region: TIGR00733
634455001839	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
634455001840	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
634455001841	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
634455001842	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
634455001843	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
634455001844	ATP binding site [chemical binding]; other site
634455001845	substrate interface [chemical binding]; other site
634455001846	Bacterial SH3 domain; Region: SH3_4; pfam06347
634455001847	Bacterial SH3 domain; Region: SH3_4; pfam06347
634455001848	pyruvate kinase; Provisional; Region: PRK06247
634455001849	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
634455001850	domain interfaces; other site
634455001851	active site
634455001852	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
634455001853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455001854	putative substrate translocation pore; other site
634455001855	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634455001856	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
634455001857	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
634455001858	G1 box; other site
634455001859	putative GEF interaction site [polypeptide binding]; other site
634455001860	GTP/Mg2+ binding site [chemical binding]; other site
634455001861	Switch I region; other site
634455001862	G2 box; other site
634455001863	G3 box; other site
634455001864	Switch II region; other site
634455001865	G4 box; other site
634455001866	G5 box; other site
634455001867	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
634455001868	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
634455001869	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
634455001870	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634455001871	hydroxyglutarate oxidase; Provisional; Region: PRK11728
634455001872	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
634455001873	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634455001874	isocitrate dehydrogenase; Validated; Region: PRK08299
634455001875	hypothetical protein; Provisional; Region: PRK08912
634455001876	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455001877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455001878	homodimer interface [polypeptide binding]; other site
634455001879	catalytic residue [active]
634455001880	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
634455001881	Nitrogen regulatory protein P-II; Region: P-II; smart00938
634455001882	glutamine synthetase; Provisional; Region: glnA; PRK09469
634455001883	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
634455001884	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
634455001885	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634455001886	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634455001887	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634455001888	Trp docking motif [polypeptide binding]; other site
634455001889	putative active site [active]
634455001890	Predicted transcriptional regulator [Transcription]; Region: COG2932
634455001891	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634455001892	Catalytic site [active]
634455001893	GTP-binding protein LepA; Provisional; Region: PRK05433
634455001894	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
634455001895	G1 box; other site
634455001896	putative GEF interaction site [polypeptide binding]; other site
634455001897	GTP/Mg2+ binding site [chemical binding]; other site
634455001898	Switch I region; other site
634455001899	G2 box; other site
634455001900	G3 box; other site
634455001901	Switch II region; other site
634455001902	G4 box; other site
634455001903	G5 box; other site
634455001904	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
634455001905	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
634455001906	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
634455001907	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
634455001908	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
634455001909	Methyltransferase domain; Region: Methyltransf_23; pfam13489
634455001910	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455001911	S-adenosylmethionine binding site [chemical binding]; other site
634455001912	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634455001913	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634455001914	ATP binding site [chemical binding]; other site
634455001915	Mg++ binding site [ion binding]; other site
634455001916	motif III; other site
634455001917	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455001918	nucleotide binding region [chemical binding]; other site
634455001919	ATP-binding site [chemical binding]; other site
634455001920	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
634455001921	putative catalytic site [active]
634455001922	putative metal binding site [ion binding]; other site
634455001923	putative phosphate binding site [ion binding]; other site
634455001924	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
634455001925	active site clefts [active]
634455001926	zinc binding site [ion binding]; other site
634455001927	dimer interface [polypeptide binding]; other site
634455001928	LabA_like proteins; Region: LabA; cd10911
634455001929	Uncharacterized conserved protein [Function unknown]; Region: COG1432
634455001930	putative metal binding site [ion binding]; other site
634455001931	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
634455001932	catalytic center binding site [active]
634455001933	ATP binding site [chemical binding]; other site
634455001934	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
634455001935	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
634455001936	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
634455001937	Zn2+ binding site [ion binding]; other site
634455001938	Mg2+ binding site [ion binding]; other site
634455001939	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
634455001940	synthetase active site [active]
634455001941	NTP binding site [chemical binding]; other site
634455001942	metal binding site [ion binding]; metal-binding site
634455001943	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
634455001944	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
634455001945	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
634455001946	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
634455001947	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
634455001948	Catalytic site [active]
634455001949	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
634455001950	ribonuclease III; Reviewed; Region: rnc; PRK00102
634455001951	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
634455001952	dimerization interface [polypeptide binding]; other site
634455001953	active site
634455001954	metal binding site [ion binding]; metal-binding site
634455001955	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
634455001956	GTPase Era; Reviewed; Region: era; PRK00089
634455001957	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
634455001958	G1 box; other site
634455001959	GTP/Mg2+ binding site [chemical binding]; other site
634455001960	Switch I region; other site
634455001961	G2 box; other site
634455001962	Switch II region; other site
634455001963	G3 box; other site
634455001964	G4 box; other site
634455001965	G5 box; other site
634455001966	KH domain; Region: KH_2; pfam07650
634455001967	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
634455001968	putative nucleotide binding site [chemical binding]; other site
634455001969	uridine monophosphate binding site [chemical binding]; other site
634455001970	homohexameric interface [polypeptide binding]; other site
634455001971	ribosome recycling factor; Reviewed; Region: frr; PRK00083
634455001972	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
634455001973	hinge region; other site
634455001974	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
634455001975	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
634455001976	catalytic residue [active]
634455001977	putative FPP diphosphate  binding site; other site
634455001978	putative FPP binding hydrophobic cleft; other site
634455001979	dimer interface [polypeptide binding]; other site
634455001980	putative IPP diphosphate binding site; other site
634455001981	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
634455001982	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
634455001983	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
634455001984	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
634455001985	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
634455001986	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
634455001987	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
634455001988	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
634455001989	active site
634455001990	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
634455001991	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
634455001992	putative substrate binding region [chemical binding]; other site
634455001993	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634455001994	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
634455001995	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634455001996	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634455001997	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634455001998	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634455001999	Surface antigen; Region: Bac_surface_Ag; pfam01103
634455002000	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
634455002001	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
634455002002	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
634455002003	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
634455002004	trimer interface [polypeptide binding]; other site
634455002005	active site
634455002006	UDP-GlcNAc binding site [chemical binding]; other site
634455002007	lipid binding site [chemical binding]; lipid-binding site
634455002008	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
634455002009	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
634455002010	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
634455002011	active site
634455002012	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
634455002013	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
634455002014	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634455002015	dimer interface [polypeptide binding]; other site
634455002016	active site
634455002017	metal binding site [ion binding]; metal-binding site
634455002018	glutathione binding site [chemical binding]; other site
634455002019	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
634455002020	Ribonuclease P; Region: Ribonuclease_P; pfam00825
634455002021	membrane protein insertase; Provisional; Region: PRK01318
634455002022	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
634455002023	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
634455002024	G1 box; other site
634455002025	GTP/Mg2+ binding site [chemical binding]; other site
634455002026	Switch I region; other site
634455002027	G2 box; other site
634455002028	G3 box; other site
634455002029	Switch II region; other site
634455002030	G4 box; other site
634455002031	G5 box; other site
634455002032	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
634455002033	homohexameric interface [polypeptide binding]; other site
634455002034	feedback inhibition sensing region; other site
634455002035	nucleotide binding site [chemical binding]; other site
634455002036	N-acetyl-L-glutamate binding site [chemical binding]; other site
634455002037	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
634455002038	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
634455002039	trimer interface [polypeptide binding]; other site
634455002040	active site
634455002041	substrate binding site [chemical binding]; other site
634455002042	CoA binding site [chemical binding]; other site
634455002043	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
634455002044	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
634455002045	metal binding site [ion binding]; metal-binding site
634455002046	dimer interface [polypeptide binding]; other site
634455002047	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
634455002048	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
634455002049	dimerization interface 3.5A [polypeptide binding]; other site
634455002050	active site
634455002051	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
634455002052	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
634455002053	putative active site [active]
634455002054	substrate binding site [chemical binding]; other site
634455002055	putative cosubstrate binding site; other site
634455002056	catalytic site [active]
634455002057	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
634455002058	substrate binding site [chemical binding]; other site
634455002059	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
634455002060	active site
634455002061	catalytic residues [active]
634455002062	metal binding site [ion binding]; metal-binding site
634455002063	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634455002064	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
634455002065	putative dimer interface [polypeptide binding]; other site
634455002066	Protein of unknown function (DUF1150); Region: DUF1150; cl11577
634455002067	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
634455002068	30S subunit binding site; other site
634455002069	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
634455002070	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
634455002071	MOSC domain; Region: MOSC; pfam03473
634455002072	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
634455002073	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
634455002074	Walker A/P-loop; other site
634455002075	ATP binding site [chemical binding]; other site
634455002076	Q-loop/lid; other site
634455002077	ABC transporter signature motif; other site
634455002078	Walker B; other site
634455002079	D-loop; other site
634455002080	H-loop/switch region; other site
634455002081	OstA-like protein; Region: OstA; cl00844
634455002082	OstA-like protein; Region: OstA; cl00844
634455002083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
634455002084	KpsF/GutQ family protein; Region: kpsF; TIGR00393
634455002085	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
634455002086	putative active site [active]
634455002087	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
634455002088	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
634455002089	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
634455002090	catalytic site [active]
634455002091	putative active site [active]
634455002092	putative substrate binding site [chemical binding]; other site
634455002093	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
634455002094	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
634455002095	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
634455002096	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
634455002097	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634455002098	short chain dehydrogenase; Provisional; Region: PRK07024
634455002099	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455002100	NAD(P) binding site [chemical binding]; other site
634455002101	active site
634455002102	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
634455002103	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
634455002104	catalytic site [active]
634455002105	G-X2-G-X-G-K; other site
634455002106	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
634455002107	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
634455002108	putative ribose interaction site [chemical binding]; other site
634455002109	putative ADP binding site [chemical binding]; other site
634455002110	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
634455002111	active site
634455002112	nucleotide binding site [chemical binding]; other site
634455002113	HIGH motif; other site
634455002114	KMSKS motif; other site
634455002115	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
634455002116	dimerization interface [polypeptide binding]; other site
634455002117	putative active cleft [active]
634455002118	replicative DNA helicase; Provisional; Region: PRK09165
634455002119	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
634455002120	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
634455002121	Walker A motif; other site
634455002122	ATP binding site [chemical binding]; other site
634455002123	Walker B motif; other site
634455002124	DNA binding loops [nucleotide binding]
634455002125	Nuclease-related domain; Region: NERD; pfam08378
634455002126	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
634455002127	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634455002128	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
634455002129	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
634455002130	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455002131	Walker A/P-loop; other site
634455002132	ATP binding site [chemical binding]; other site
634455002133	Q-loop/lid; other site
634455002134	ABC transporter signature motif; other site
634455002135	Walker B; other site
634455002136	D-loop; other site
634455002137	H-loop/switch region; other site
634455002138	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
634455002139	Permease; Region: Permease; pfam02405
634455002140	DNA repair protein RadA; Provisional; Region: PRK11823
634455002141	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
634455002142	Walker A motif/ATP binding site; other site
634455002143	ATP binding site [chemical binding]; other site
634455002144	Walker B motif; other site
634455002145	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
634455002146	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
634455002147	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634455002148	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
634455002149	Proline dehydrogenase; Region: Pro_dh; pfam01619
634455002150	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
634455002151	NAD(P) binding site [chemical binding]; other site
634455002152	catalytic residues [active]
634455002153	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
634455002154	Transcriptional regulators [Transcription]; Region: GntR; COG1802
634455002155	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634455002156	DNA-binding site [nucleotide binding]; DNA binding site
634455002157	FCD domain; Region: FCD; pfam07729
634455002158	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634455002159	acetyl-CoA synthetase; Provisional; Region: PRK00174
634455002160	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634455002161	acyl-activating enzyme (AAE) consensus motif; other site
634455002162	AMP binding site [chemical binding]; other site
634455002163	active site
634455002164	CoA binding site [chemical binding]; other site
634455002165	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
634455002166	FtsJ-like methyltransferase; Region: FtsJ; cl17430
634455002167	Protein of unknown function (DUF423); Region: DUF423; pfam04241
634455002168	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
634455002169	hypothetical protein; Validated; Region: PRK09039
634455002170	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
634455002171	FAD binding domain; Region: FAD_binding_4; pfam01565
634455002172	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
634455002173	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
634455002174	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
634455002175	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634455002176	active site
634455002177	multifunctional aminopeptidase A; Provisional; Region: PRK00913
634455002178	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
634455002179	interface (dimer of trimers) [polypeptide binding]; other site
634455002180	Substrate-binding/catalytic site; other site
634455002181	Zn-binding sites [ion binding]; other site
634455002182	DNA polymerase III subunit chi; Validated; Region: PRK05728
634455002183	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634455002184	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
634455002185	active site
634455002186	catalytic tetrad [active]
634455002187	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
634455002188	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634455002189	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634455002190	protein binding site [polypeptide binding]; other site
634455002191	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
634455002192	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455002193	ATP binding site [chemical binding]; other site
634455002194	putative Mg++ binding site [ion binding]; other site
634455002195	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455002196	nucleotide binding region [chemical binding]; other site
634455002197	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
634455002198	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
634455002199	dimerization interface [polypeptide binding]; other site
634455002200	domain crossover interface; other site
634455002201	redox-dependent activation switch; other site
634455002202	ornithine carbamoyltransferase; Provisional; Region: PRK00779
634455002203	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
634455002204	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
634455002205	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
634455002206	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634455002207	inhibitor-cofactor binding pocket; inhibition site
634455002208	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455002209	catalytic residue [active]
634455002210	RecX family; Region: RecX; pfam02631
634455002211	CHAP domain; Region: CHAP; cl17642
634455002212	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
634455002213	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
634455002214	intersubunit interface [polypeptide binding]; other site
634455002215	active site
634455002216	Zn2+ binding site [ion binding]; other site
634455002217	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
634455002218	Cupin domain; Region: Cupin_2; cl17218
634455002219	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
634455002220	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
634455002221	motif II; other site
634455002222	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
634455002223	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
634455002224	active site
634455002225	Riboflavin kinase; Region: Flavokinase; smart00904
634455002226	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
634455002227	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634455002228	active site
634455002229	HIGH motif; other site
634455002230	nucleotide binding site [chemical binding]; other site
634455002231	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
634455002232	active site
634455002233	KMSKS motif; other site
634455002234	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
634455002235	tRNA binding surface [nucleotide binding]; other site
634455002236	anticodon binding site; other site
634455002237	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
634455002238	lipoprotein signal peptidase; Provisional; Region: PRK14770
634455002239	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
634455002240	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
634455002241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455002242	ATP binding site [chemical binding]; other site
634455002243	Mg2+ binding site [ion binding]; other site
634455002244	G-X-G motif; other site
634455002245	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
634455002246	ATP binding site [chemical binding]; other site
634455002247	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
634455002248	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
634455002249	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634455002250	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
634455002251	EamA-like transporter family; Region: EamA; pfam00892
634455002252	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
634455002253	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455002254	Mg2+ binding site [ion binding]; other site
634455002255	G-X-G motif; other site
634455002256	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
634455002257	anchoring element; other site
634455002258	dimer interface [polypeptide binding]; other site
634455002259	ATP binding site [chemical binding]; other site
634455002260	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
634455002261	active site
634455002262	putative metal-binding site [ion binding]; other site
634455002263	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
634455002264	Rrf2 family protein; Region: rrf2_super; TIGR00738
634455002265	Transcriptional regulator; Region: Rrf2; pfam02082
634455002266	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
634455002267	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
634455002268	dimer interface [polypeptide binding]; other site
634455002269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455002270	catalytic residue [active]
634455002271	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
634455002272	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634455002273	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634455002274	ligand binding site [chemical binding]; other site
634455002275	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
634455002276	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
634455002277	C-terminal peptidase (prc); Region: prc; TIGR00225
634455002278	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
634455002279	protein binding site [polypeptide binding]; other site
634455002280	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
634455002281	Catalytic dyad [active]
634455002282	Exoribonuclease R [Transcription]; Region: VacB; COG0557
634455002283	RNB domain; Region: RNB; pfam00773
634455002284	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
634455002285	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
634455002286	active site
634455002287	interdomain interaction site; other site
634455002288	putative metal-binding site [ion binding]; other site
634455002289	nucleotide binding site [chemical binding]; other site
634455002290	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
634455002291	domain I; other site
634455002292	DNA binding groove [nucleotide binding]
634455002293	phosphate binding site [ion binding]; other site
634455002294	domain II; other site
634455002295	domain III; other site
634455002296	nucleotide binding site [chemical binding]; other site
634455002297	catalytic site [active]
634455002298	domain IV; other site
634455002299	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
634455002300	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634455002301	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634455002302	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634455002303	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
634455002304	DNA protecting protein DprA; Region: dprA; TIGR00732
634455002305	DDE superfamily endonuclease; Region: DDE_5; pfam13546
634455002306	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455002307	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455002308	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
634455002309	DNA protecting protein DprA; Region: dprA; TIGR00732
634455002310	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
634455002311	dihydroorotase; Validated; Region: pyrC; PRK09357
634455002312	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634455002313	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
634455002314	active site
634455002315	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
634455002316	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
634455002317	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
634455002318	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
634455002319	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634455002320	active site
634455002321	HIGH motif; other site
634455002322	nucleotide binding site [chemical binding]; other site
634455002323	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
634455002324	active site
634455002325	KMSKS motif; other site
634455002326	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
634455002327	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
634455002328	Competence protein; Region: Competence; pfam03772
634455002329	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
634455002330	Predicted ATPase [General function prediction only]; Region: COG1485
634455002331	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
634455002332	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
634455002333	TPP-binding site [chemical binding]; other site
634455002334	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
634455002335	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
634455002336	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634455002337	E3 interaction surface; other site
634455002338	lipoyl attachment site [posttranslational modification]; other site
634455002339	e3 binding domain; Region: E3_binding; pfam02817
634455002340	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
634455002341	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634455002342	E3 interaction surface; other site
634455002343	lipoyl attachment site [posttranslational modification]; other site
634455002344	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
634455002345	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634455002346	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634455002347	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
634455002348	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
634455002349	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
634455002350	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
634455002351	homotetramer interface [polypeptide binding]; other site
634455002352	ligand binding site [chemical binding]; other site
634455002353	catalytic site [active]
634455002354	NAD binding site [chemical binding]; other site
634455002355	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
634455002356	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634455002357	putative acyl-acceptor binding pocket; other site
634455002358	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
634455002359	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
634455002360	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634455002361	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
634455002362	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
634455002363	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
634455002364	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
634455002365	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
634455002366	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
634455002367	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
634455002368	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
634455002369	motif 1; other site
634455002370	active site
634455002371	motif 2; other site
634455002372	motif 3; other site
634455002373	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
634455002374	TraB family; Region: TraB; cl12050
634455002375	Predicted membrane protein [Function unknown]; Region: COG2246
634455002376	GtrA-like protein; Region: GtrA; pfam04138
634455002377	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
634455002378	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634455002379	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634455002380	ligand binding site [chemical binding]; other site
634455002381	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
634455002382	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
634455002383	ADP binding site [chemical binding]; other site
634455002384	magnesium binding site [ion binding]; other site
634455002385	putative shikimate binding site; other site
634455002386	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
634455002387	active site
634455002388	dimer interface [polypeptide binding]; other site
634455002389	metal binding site [ion binding]; metal-binding site
634455002390	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
634455002391	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455002392	active site
634455002393	DNA binding site [nucleotide binding]
634455002394	Int/Topo IB signature motif; other site
634455002395	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
634455002396	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
634455002397	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
634455002398	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
634455002399	putative MPT binding site; other site
634455002400	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
634455002401	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634455002402	active site
634455002403	nucleotide binding site [chemical binding]; other site
634455002404	HIGH motif; other site
634455002405	KMSKS motif; other site
634455002406	Predicted integral membrane protein [Function unknown]; Region: COG0392
634455002407	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
634455002408	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
634455002409	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
634455002410	UGMP family protein; Validated; Region: PRK09604
634455002411	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
634455002412	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
634455002413	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
634455002414	domain interfaces; other site
634455002415	active site
634455002416	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
634455002417	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
634455002418	active site
634455002419	preprotein translocase subunit SecB; Validated; Region: PRK05751
634455002420	SecA binding site; other site
634455002421	Preprotein binding site; other site
634455002422	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634455002423	catalytic core [active]
634455002424	Tim44-like domain; Region: Tim44; pfam04280
634455002425	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
634455002426	DNA methylase; Region: N6_N4_Mtase; pfam01555
634455002427	Haem-binding domain; Region: Haem_bd; pfam14376
634455002428	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
634455002429	Smr domain; Region: Smr; pfam01713
634455002430	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
634455002431	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
634455002432	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634455002433	Qi binding site; other site
634455002434	intrachain domain interface; other site
634455002435	interchain domain interface [polypeptide binding]; other site
634455002436	heme bH binding site [chemical binding]; other site
634455002437	heme bL binding site [chemical binding]; other site
634455002438	Qo binding site; other site
634455002439	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
634455002440	intrachain domain interface; other site
634455002441	interchain domain interface [polypeptide binding]; other site
634455002442	Qi binding site; other site
634455002443	Qo binding site; other site
634455002444	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
634455002445	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
634455002446	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
634455002447	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
634455002448	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
634455002449	FMN binding site [chemical binding]; other site
634455002450	dimer interface [polypeptide binding]; other site
634455002451	ornithine cyclodeaminase; Validated; Region: PRK07340
634455002452	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
634455002453	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
634455002454	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
634455002455	NAD(P) binding site [chemical binding]; other site
634455002456	catalytic residues [active]
634455002457	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455002458	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455002459	WHG domain; Region: WHG; pfam13305
634455002460	Transposase; Region: HTH_Tnp_1; pfam01527
634455002461	HTH-like domain; Region: HTH_21; pfam13276
634455002462	Integrase core domain; Region: rve; pfam00665
634455002463	Integrase core domain; Region: rve_3; pfam13683
634455002464	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455002465	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634455002466	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455002467	catalytic residues [active]
634455002468	catalytic nucleophile [active]
634455002469	Presynaptic Site I dimer interface [polypeptide binding]; other site
634455002470	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634455002471	Synaptic Flat tetramer interface [polypeptide binding]; other site
634455002472	Synaptic Site I dimer interface [polypeptide binding]; other site
634455002473	DNA binding site [nucleotide binding]
634455002474	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455002475	DNA-binding interface [nucleotide binding]; DNA binding site
634455002476	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455002477	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455002478	active site
634455002479	DNA binding site [nucleotide binding]
634455002480	Int/Topo IB signature motif; other site
634455002481	integrase; Provisional; Region: PRK09692
634455002482	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
634455002483	active site
634455002484	Int/Topo IB signature motif; other site
634455002485	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
634455002486	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
634455002487	HicB family; Region: HicB; pfam05534
634455002488	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
634455002489	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
634455002490	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
634455002491	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455002492	Walker A/P-loop; other site
634455002493	ATP binding site [chemical binding]; other site
634455002494	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
634455002495	synthetase active site [active]
634455002496	NTP binding site [chemical binding]; other site
634455002497	metal binding site [ion binding]; metal-binding site
634455002498	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634455002499	Transposase; Region: HTH_Tnp_1; pfam01527
634455002500	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634455002501	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455002502	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634455002503	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455002504	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634455002505	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634455002506	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634455002507	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634455002508	HTH-like domain; Region: HTH_21; pfam13276
634455002509	Integrase core domain; Region: rve; pfam00665
634455002510	Integrase core domain; Region: rve_3; pfam13683
634455002511	Transposase; Region: HTH_Tnp_1; pfam01527
634455002512	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634455002513	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455002514	non-specific DNA binding site [nucleotide binding]; other site
634455002515	salt bridge; other site
634455002516	sequence-specific DNA binding site [nucleotide binding]; other site
634455002517	hypothetical protein; Validated; Region: PRK07078
634455002518	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
634455002519	active site
634455002520	metal binding site [ion binding]; metal-binding site
634455002521	interdomain interaction site; other site
634455002522	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
634455002523	Domain of unknown function (DUF927); Region: DUF927; pfam06048
634455002524	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
634455002525	active site
634455002526	oligomerization interface [polypeptide binding]; other site
634455002527	metal binding site [ion binding]; metal-binding site
634455002528	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
634455002529	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
634455002530	active site
634455002531	FMN binding site [chemical binding]; other site
634455002532	substrate binding site [chemical binding]; other site
634455002533	homotetramer interface [polypeptide binding]; other site
634455002534	catalytic residue [active]
634455002535	Helix-turn-helix domain; Region: HTH_20; pfam12840
634455002536	dimerization interface [polypeptide binding]; other site
634455002537	putative DNA binding site [nucleotide binding]; other site
634455002538	putative Zn2+ binding site [ion binding]; other site
634455002539	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634455002540	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
634455002541	putative NAD(P) binding site [chemical binding]; other site
634455002542	putative substrate binding site [chemical binding]; other site
634455002543	catalytic Zn binding site [ion binding]; other site
634455002544	structural Zn binding site [ion binding]; other site
634455002545	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
634455002546	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
634455002547	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
634455002548	NAD binding site [chemical binding]; other site
634455002549	homodimer interface [polypeptide binding]; other site
634455002550	active site
634455002551	substrate binding site [chemical binding]; other site
634455002552	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
634455002553	diaminopimelate decarboxylase; Region: lysA; TIGR01048
634455002554	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
634455002555	active site
634455002556	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634455002557	substrate binding site [chemical binding]; other site
634455002558	catalytic residues [active]
634455002559	dimer interface [polypeptide binding]; other site
634455002560	argininosuccinate lyase; Provisional; Region: PRK00855
634455002561	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
634455002562	active sites [active]
634455002563	tetramer interface [polypeptide binding]; other site
634455002564	N-formylglutamate amidohydrolase; Region: FGase; cl01522
634455002565	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
634455002566	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
634455002567	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
634455002568	shikimate binding site; other site
634455002569	NAD(P) binding site [chemical binding]; other site
634455002570	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
634455002571	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
634455002572	CoA-binding site [chemical binding]; other site
634455002573	ATP-binding [chemical binding]; other site
634455002574	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
634455002575	active site
634455002576	catalytic site [active]
634455002577	substrate binding site [chemical binding]; other site
634455002578	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455002579	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
634455002580	putative ADP-binding pocket [chemical binding]; other site
634455002581	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
634455002582	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
634455002583	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
634455002584	substrate binding site [chemical binding]; other site
634455002585	hexamer interface [polypeptide binding]; other site
634455002586	metal binding site [ion binding]; metal-binding site
634455002587	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
634455002588	putative RNA binding site [nucleotide binding]; other site
634455002589	16S rRNA methyltransferase B; Provisional; Region: PRK10901
634455002590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455002591	S-adenosylmethionine binding site [chemical binding]; other site
634455002592	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
634455002593	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
634455002594	active site
634455002595	substrate binding site [chemical binding]; other site
634455002596	cosubstrate binding site; other site
634455002597	catalytic site [active]
634455002598	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
634455002599	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
634455002600	dimerization interface [polypeptide binding]; other site
634455002601	putative ATP binding site [chemical binding]; other site
634455002602	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
634455002603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
634455002604	polyphosphate kinase; Provisional; Region: PRK05443
634455002605	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
634455002606	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
634455002607	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
634455002608	putative domain interface [polypeptide binding]; other site
634455002609	putative active site [active]
634455002610	catalytic site [active]
634455002611	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
634455002612	putative domain interface [polypeptide binding]; other site
634455002613	putative active site [active]
634455002614	catalytic site [active]
634455002615	exopolyphosphatase; Region: exo_poly_only; TIGR03706
634455002616	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
634455002617	Cache domain; Region: Cache_1; pfam02743
634455002618	cyclase homology domain; Region: CHD; cd07302
634455002619	nucleotidyl binding site; other site
634455002620	metal binding site [ion binding]; metal-binding site
634455002621	dimer interface [polypeptide binding]; other site
634455002622	Permease; Region: Permease; pfam02405
634455002623	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
634455002624	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455002625	Q-loop/lid; other site
634455002626	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
634455002627	mce related protein; Region: MCE; pfam02470
634455002628	sugar binding site [chemical binding]; other site
634455002629	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
634455002630	Inward rectifier potassium channel; Region: IRK; pfam01007
634455002631	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634455002632	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634455002633	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634455002634	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634455002635	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
634455002636	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
634455002637	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
634455002638	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
634455002639	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
634455002640	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
634455002641	catalytic residues [active]
634455002642	central insert; other site
634455002643	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
634455002644	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
634455002645	heme exporter protein CcmC; Region: ccmC; TIGR01191
634455002646	YciI-like protein; Reviewed; Region: PRK12863
634455002647	EVE domain; Region: EVE; pfam01878
634455002648	Putative phosphatase (DUF442); Region: DUF442; cl17385
634455002649	EcsC protein family; Region: EcsC; pfam12787
634455002650	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
634455002651	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
634455002652	dimerization interface [polypeptide binding]; other site
634455002653	ligand binding site [chemical binding]; other site
634455002654	NADP binding site [chemical binding]; other site
634455002655	catalytic site [active]
634455002656	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
634455002657	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
634455002658	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
634455002659	Protein of unknown function; Region: DUF3971; pfam13116
634455002660	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634455002661	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
634455002662	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634455002663	metal binding triad; other site
634455002664	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634455002665	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634455002666	metal binding triad; other site
634455002667	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634455002668	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
634455002669	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
634455002670	catalytic triad [active]
634455002671	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
634455002672	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455002673	putative substrate translocation pore; other site
634455002674	RmuC family; Region: RmuC; pfam02646
634455002675	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634455002676	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455002677	active site
634455002678	phosphorylation site [posttranslational modification]
634455002679	intermolecular recognition site; other site
634455002680	dimerization interface [polypeptide binding]; other site
634455002681	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455002682	DNA binding site [nucleotide binding]
634455002683	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634455002684	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634455002685	dimerization interface [polypeptide binding]; other site
634455002686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455002687	ATP binding site [chemical binding]; other site
634455002688	Mg2+ binding site [ion binding]; other site
634455002689	G-X-G motif; other site
634455002690	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634455002691	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634455002692	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455002693	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455002694	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634455002695	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
634455002696	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
634455002697	23S rRNA interface [nucleotide binding]; other site
634455002698	L7/L12 interface [polypeptide binding]; other site
634455002699	putative thiostrepton binding site; other site
634455002700	L25 interface [polypeptide binding]; other site
634455002701	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
634455002702	mRNA/rRNA interface [nucleotide binding]; other site
634455002703	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
634455002704	23S rRNA interface [nucleotide binding]; other site
634455002705	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
634455002706	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
634455002707	L11 interface [polypeptide binding]; other site
634455002708	putative EF-Tu interaction site [polypeptide binding]; other site
634455002709	putative EF-G interaction site [polypeptide binding]; other site
634455002710	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
634455002711	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
634455002712	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
634455002713	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
634455002714	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
634455002715	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
634455002716	RPB1 interaction site [polypeptide binding]; other site
634455002717	RPB11 interaction site [polypeptide binding]; other site
634455002718	RPB10 interaction site [polypeptide binding]; other site
634455002719	RPB3 interaction site [polypeptide binding]; other site
634455002720	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
634455002721	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
634455002722	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
634455002723	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
634455002724	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
634455002725	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
634455002726	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
634455002727	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
634455002728	DNA binding site [nucleotide binding]
634455002729	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
634455002730	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
634455002731	S17 interaction site [polypeptide binding]; other site
634455002732	S8 interaction site; other site
634455002733	16S rRNA interaction site [nucleotide binding]; other site
634455002734	streptomycin interaction site [chemical binding]; other site
634455002735	23S rRNA interaction site [nucleotide binding]; other site
634455002736	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
634455002737	30S ribosomal protein S7; Validated; Region: PRK05302
634455002738	elongation factor Tu; Reviewed; Region: PRK00049
634455002739	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
634455002740	G1 box; other site
634455002741	GEF interaction site [polypeptide binding]; other site
634455002742	GTP/Mg2+ binding site [chemical binding]; other site
634455002743	Switch I region; other site
634455002744	G2 box; other site
634455002745	G3 box; other site
634455002746	Switch II region; other site
634455002747	G4 box; other site
634455002748	G5 box; other site
634455002749	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
634455002750	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
634455002751	Antibiotic Binding Site [chemical binding]; other site
634455002752	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
634455002753	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
634455002754	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
634455002755	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
634455002756	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
634455002757	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
634455002758	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
634455002759	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
634455002760	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
634455002761	putative translocon binding site; other site
634455002762	protein-rRNA interface [nucleotide binding]; other site
634455002763	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
634455002764	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
634455002765	G-X-X-G motif; other site
634455002766	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
634455002767	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
634455002768	23S rRNA interface [nucleotide binding]; other site
634455002769	5S rRNA interface [nucleotide binding]; other site
634455002770	putative antibiotic binding site [chemical binding]; other site
634455002771	L25 interface [polypeptide binding]; other site
634455002772	L27 interface [polypeptide binding]; other site
634455002773	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
634455002774	23S rRNA interface [nucleotide binding]; other site
634455002775	putative translocon interaction site; other site
634455002776	signal recognition particle (SRP54) interaction site; other site
634455002777	L23 interface [polypeptide binding]; other site
634455002778	trigger factor interaction site; other site
634455002779	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
634455002780	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
634455002781	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
634455002782	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
634455002783	RNA binding site [nucleotide binding]; other site
634455002784	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
634455002785	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
634455002786	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
634455002787	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
634455002788	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
634455002789	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
634455002790	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
634455002791	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
634455002792	5S rRNA interface [nucleotide binding]; other site
634455002793	23S rRNA interface [nucleotide binding]; other site
634455002794	L5 interface [polypeptide binding]; other site
634455002795	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
634455002796	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
634455002797	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
634455002798	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
634455002799	23S rRNA binding site [nucleotide binding]; other site
634455002800	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
634455002801	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
634455002802	SecY translocase; Region: SecY; pfam00344
634455002803	adenylate kinase; Reviewed; Region: adk; PRK00279
634455002804	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
634455002805	AMP-binding site [chemical binding]; other site
634455002806	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
634455002807	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
634455002808	30S ribosomal protein S13; Region: bact_S13; TIGR03631
634455002809	30S ribosomal protein S11; Validated; Region: PRK05309
634455002810	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
634455002811	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
634455002812	alphaNTD - beta interaction site [polypeptide binding]; other site
634455002813	alphaNTD homodimer interface [polypeptide binding]; other site
634455002814	alphaNTD - beta' interaction site [polypeptide binding]; other site
634455002815	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
634455002816	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
634455002817	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
634455002818	NMT1-like family; Region: NMT1_2; pfam13379
634455002819	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634455002820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455002821	dimer interface [polypeptide binding]; other site
634455002822	conserved gate region; other site
634455002823	putative PBP binding loops; other site
634455002824	ABC-ATPase subunit interface; other site
634455002825	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634455002826	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634455002827	Walker A/P-loop; other site
634455002828	ATP binding site [chemical binding]; other site
634455002829	Q-loop/lid; other site
634455002830	ABC transporter signature motif; other site
634455002831	Walker B; other site
634455002832	D-loop; other site
634455002833	H-loop/switch region; other site
634455002834	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634455002835	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634455002836	Protein export membrane protein; Region: SecD_SecF; cl14618
634455002837	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
634455002838	Protein export membrane protein; Region: SecD_SecF; cl14618
634455002839	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
634455002840	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455002841	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455002842	putative transporter; Provisional; Region: PRK10504
634455002843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455002844	putative substrate translocation pore; other site
634455002845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455002846	CsbD-like; Region: CsbD; pfam05532
634455002847	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
634455002848	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
634455002849	RNA/DNA hybrid binding site [nucleotide binding]; other site
634455002850	active site
634455002851	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
634455002852	DNA methylase; Region: N6_N4_Mtase; pfam01555
634455002853	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
634455002854	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634455002855	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
634455002856	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
634455002857	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
634455002858	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
634455002859	Protein of unknown function DUF58; Region: DUF58; pfam01882
634455002860	MoxR-like ATPases [General function prediction only]; Region: COG0714
634455002861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
634455002862	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
634455002863	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
634455002864	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
634455002865	active site
634455002866	NTP binding site [chemical binding]; other site
634455002867	metal binding triad [ion binding]; metal-binding site
634455002868	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
634455002869	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634455002870	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634455002871	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455002872	Walker A/P-loop; other site
634455002873	ATP binding site [chemical binding]; other site
634455002874	Q-loop/lid; other site
634455002875	ABC transporter signature motif; other site
634455002876	Walker B; other site
634455002877	D-loop; other site
634455002878	H-loop/switch region; other site
634455002879	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634455002880	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634455002881	E3 interaction surface; other site
634455002882	lipoyl attachment site [posttranslational modification]; other site
634455002883	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455002884	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634455002885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455002886	putative substrate translocation pore; other site
634455002887	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
634455002888	putative active site [active]
634455002889	Ap4A binding site [chemical binding]; other site
634455002890	nudix motif; other site
634455002891	putative metal binding site [ion binding]; other site
634455002892	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
634455002893	NodB motif; other site
634455002894	putative active site [active]
634455002895	putative catalytic site [active]
634455002896	Zn binding site [ion binding]; other site
634455002897	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
634455002898	C-terminal peptidase (prc); Region: prc; TIGR00225
634455002899	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
634455002900	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
634455002901	Catalytic dyad [active]
634455002902	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
634455002903	Peptidase family M23; Region: Peptidase_M23; pfam01551
634455002904	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
634455002905	phosphoglyceromutase; Provisional; Region: PRK05434
634455002906	threonine dehydratase; Provisional; Region: PRK07334
634455002907	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
634455002908	tetramer interface [polypeptide binding]; other site
634455002909	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455002910	catalytic residue [active]
634455002911	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
634455002912	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
634455002913	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
634455002914	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
634455002915	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
634455002916	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634455002917	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
634455002918	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
634455002919	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634455002920	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634455002921	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
634455002922	IMP binding site; other site
634455002923	dimer interface [polypeptide binding]; other site
634455002924	partial ornithine binding site; other site
634455002925	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
634455002926	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
634455002927	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
634455002928	catalytic site [active]
634455002929	subunit interface [polypeptide binding]; other site
634455002930	Yqey-like protein; Region: YqeY; pfam09424
634455002931	DNA primase; Validated; Region: dnaG; PRK05667
634455002932	CHC2 zinc finger; Region: zf-CHC2; pfam01807
634455002933	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
634455002934	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
634455002935	active site
634455002936	metal binding site [ion binding]; metal-binding site
634455002937	interdomain interaction site; other site
634455002938	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
634455002939	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
634455002940	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
634455002941	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
634455002942	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634455002943	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
634455002944	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634455002945	DNA binding residues [nucleotide binding]
634455002946	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
634455002947	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
634455002948	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
634455002949	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
634455002950	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
634455002951	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
634455002952	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
634455002953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634455002954	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455002955	S-adenosylmethionine binding site [chemical binding]; other site
634455002956	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
634455002957	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
634455002958	SurA N-terminal domain; Region: SurA_N; pfam09312
634455002959	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
634455002960	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
634455002961	OstA-like protein; Region: OstA; cl00844
634455002962	Organic solvent tolerance protein; Region: OstA_C; pfam04453
634455002963	Predicted permeases [General function prediction only]; Region: COG0795
634455002964	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634455002965	Predicted permeases [General function prediction only]; Region: COG0795
634455002966	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634455002967	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
634455002968	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634455002969	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455002970	Walker A/P-loop; other site
634455002971	ATP binding site [chemical binding]; other site
634455002972	Q-loop/lid; other site
634455002973	ABC transporter signature motif; other site
634455002974	Walker B; other site
634455002975	D-loop; other site
634455002976	H-loop/switch region; other site
634455002977	Transcriptional regulators [Transcription]; Region: GntR; COG1802
634455002978	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634455002979	DNA-binding site [nucleotide binding]; DNA binding site
634455002980	FCD domain; Region: FCD; pfam07729
634455002981	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
634455002982	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
634455002983	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
634455002984	Switch I; other site
634455002985	Switch II; other site
634455002986	septum formation inhibitor; Reviewed; Region: minC; PRK05177
634455002987	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
634455002988	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
634455002989	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634455002990	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
634455002991	C-terminal domain interface [polypeptide binding]; other site
634455002992	GSH binding site (G-site) [chemical binding]; other site
634455002993	dimer interface [polypeptide binding]; other site
634455002994	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
634455002995	N-terminal domain interface [polypeptide binding]; other site
634455002996	dimer interface [polypeptide binding]; other site
634455002997	substrate binding pocket (H-site) [chemical binding]; other site
634455002998	Predicted flavoproteins [General function prediction only]; Region: COG2081
634455002999	Predicted methyltransferases [General function prediction only]; Region: COG0313
634455003000	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
634455003001	putative SAM binding site [chemical binding]; other site
634455003002	putative homodimer interface [polypeptide binding]; other site
634455003003	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
634455003004	putative ligand binding site [chemical binding]; other site
634455003005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634455003006	TPR motif; other site
634455003007	TPR repeat; Region: TPR_11; pfam13414
634455003008	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634455003009	TPR motif; other site
634455003010	binding surface
634455003011	TPR repeat; Region: TPR_11; pfam13414
634455003012	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
634455003013	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
634455003014	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
634455003015	S-formylglutathione hydrolase; Region: PLN02442
634455003016	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
634455003017	putative active site [active]
634455003018	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
634455003019	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
634455003020	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
634455003021	Walker A/P-loop; other site
634455003022	ATP binding site [chemical binding]; other site
634455003023	Q-loop/lid; other site
634455003024	ABC transporter signature motif; other site
634455003025	Walker B; other site
634455003026	D-loop; other site
634455003027	H-loop/switch region; other site
634455003028	zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717
634455003029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455003030	active site
634455003031	phosphorylation site [posttranslational modification]
634455003032	intermolecular recognition site; other site
634455003033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455003034	active site
634455003035	phosphorylation site [posttranslational modification]
634455003036	intermolecular recognition site; other site
634455003037	dimerization interface [polypeptide binding]; other site
634455003038	Winged helix-turn helix; Region: HTH_29; pfam13551
634455003039	Integrase core domain; Region: rve; pfam00665
634455003040	Integrase core domain; Region: rve_3; pfam13683
634455003041	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634455003042	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455003043	ATP binding site [chemical binding]; other site
634455003044	Mg2+ binding site [ion binding]; other site
634455003045	G-X-G motif; other site
634455003046	Response regulator receiver domain; Region: Response_reg; pfam00072
634455003047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455003048	active site
634455003049	phosphorylation site [posttranslational modification]
634455003050	intermolecular recognition site; other site
634455003051	dimerization interface [polypeptide binding]; other site
634455003052	PAS fold; Region: PAS_4; pfam08448
634455003053	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455003054	dimer interface [polypeptide binding]; other site
634455003055	phosphorylation site [posttranslational modification]
634455003056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455003057	ATP binding site [chemical binding]; other site
634455003058	Mg2+ binding site [ion binding]; other site
634455003059	G-X-G motif; other site
634455003060	Response regulator receiver domain; Region: Response_reg; pfam00072
634455003061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455003062	active site
634455003063	phosphorylation site [posttranslational modification]
634455003064	intermolecular recognition site; other site
634455003065	dimerization interface [polypeptide binding]; other site
634455003066	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
634455003067	active site
634455003068	HslU subunit interaction site [polypeptide binding]; other site
634455003069	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
634455003070	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455003071	Walker A motif; other site
634455003072	ATP binding site [chemical binding]; other site
634455003073	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
634455003074	Walker B motif; other site
634455003075	arginine finger; other site
634455003076	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
634455003077	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
634455003078	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
634455003079	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634455003080	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634455003081	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634455003082	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
634455003083	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634455003084	catalytic loop [active]
634455003085	iron binding site [ion binding]; other site
634455003086	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634455003087	Cytochrome c; Region: Cytochrom_C; pfam00034
634455003088	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634455003089	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634455003090	Cytochrome c; Region: Cytochrom_C; pfam00034
634455003091	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
634455003092	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
634455003093	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
634455003094	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
634455003095	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
634455003096	23S rRNA binding site [nucleotide binding]; other site
634455003097	L21 binding site [polypeptide binding]; other site
634455003098	L13 binding site [polypeptide binding]; other site
634455003099	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
634455003100	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
634455003101	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
634455003102	dimer interface [polypeptide binding]; other site
634455003103	motif 1; other site
634455003104	active site
634455003105	motif 2; other site
634455003106	motif 3; other site
634455003107	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
634455003108	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
634455003109	putative tRNA-binding site [nucleotide binding]; other site
634455003110	B3/4 domain; Region: B3_4; pfam03483
634455003111	tRNA synthetase B5 domain; Region: B5; smart00874
634455003112	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
634455003113	motif 1; other site
634455003114	dimer interface [polypeptide binding]; other site
634455003115	motif 3; other site
634455003116	motif 2; other site
634455003117	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
634455003118	PBP superfamily domain; Region: PBP_like_2; cl17296
634455003119	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
634455003120	peptide binding site [polypeptide binding]; other site
634455003121	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
634455003122	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634455003123	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
634455003124	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
634455003125	ligand binding site [chemical binding]; other site
634455003126	flexible hinge region; other site
634455003127	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
634455003128	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
634455003129	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
634455003130	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634455003131	RNA binding surface [nucleotide binding]; other site
634455003132	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
634455003133	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
634455003134	G1 box; other site
634455003135	putative GEF interaction site [polypeptide binding]; other site
634455003136	GTP/Mg2+ binding site [chemical binding]; other site
634455003137	Switch I region; other site
634455003138	G2 box; other site
634455003139	G3 box; other site
634455003140	Switch II region; other site
634455003141	G4 box; other site
634455003142	G5 box; other site
634455003143	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
634455003144	hypothetical protein; Provisional; Region: PRK08999
634455003145	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
634455003146	tartrate dehydrogenase; Region: TTC; TIGR02089
634455003147	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
634455003148	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
634455003149	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
634455003150	active site
634455003151	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
634455003152	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455003153	S-adenosylmethionine binding site [chemical binding]; other site
634455003154	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
634455003155	Part of AAA domain; Region: AAA_19; pfam13245
634455003156	Family description; Region: UvrD_C_2; pfam13538
634455003157	DNA repair protein radc; Region: radc; TIGR00608
634455003158	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
634455003159	DNA repair protein radc; Region: radc; TIGR00608
634455003160	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
634455003161	MPN+ (JAMM) motif; other site
634455003162	Zinc-binding site [ion binding]; other site
634455003163	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
634455003164	ATP-grasp domain; Region: ATP-grasp; pfam02222
634455003165	AIR carboxylase; Region: AIRC; pfam00731
634455003166	Protein of unknown function (DUF465); Region: DUF465; cl01070
634455003167	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
634455003168	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634455003169	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
634455003170	putative dimer interface [polypeptide binding]; other site
634455003171	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
634455003172	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
634455003173	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
634455003174	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
634455003175	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
634455003176	Protein export membrane protein; Region: SecD_SecF; pfam02355
634455003177	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
634455003178	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
634455003179	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
634455003180	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
634455003181	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
634455003182	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
634455003183	Class I ribonucleotide reductase; Region: RNR_I; cd01679
634455003184	active site
634455003185	dimer interface [polypeptide binding]; other site
634455003186	catalytic residues [active]
634455003187	effector binding site; other site
634455003188	R2 peptide binding site; other site
634455003189	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
634455003190	dimer interface [polypeptide binding]; other site
634455003191	putative radical transfer pathway; other site
634455003192	diiron center [ion binding]; other site
634455003193	tyrosyl radical; other site
634455003194	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
634455003195	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
634455003196	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
634455003197	substrate binding pocket [chemical binding]; other site
634455003198	chain length determination region; other site
634455003199	substrate-Mg2+ binding site; other site
634455003200	catalytic residues [active]
634455003201	aspartate-rich region 1; other site
634455003202	active site lid residues [active]
634455003203	aspartate-rich region 2; other site
634455003204	glutamate racemase; Provisional; Region: PRK00865
634455003205	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634455003206	active site
634455003207	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
634455003208	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
634455003209	dimer interface [polypeptide binding]; other site
634455003210	active site
634455003211	citrylCoA binding site [chemical binding]; other site
634455003212	NADH binding [chemical binding]; other site
634455003213	cationic pore residues; other site
634455003214	oxalacetate/citrate binding site [chemical binding]; other site
634455003215	coenzyme A binding site [chemical binding]; other site
634455003216	catalytic triad [active]
634455003217	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634455003218	catalytic core [active]
634455003219	chorismate mutase; Provisional; Region: PRK09239
634455003220	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
634455003221	active site
634455003222	metal binding site [ion binding]; metal-binding site
634455003223	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
634455003224	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
634455003225	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
634455003226	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
634455003227	AAA domain; Region: AAA_23; pfam13476
634455003228	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
634455003229	Walker A/P-loop; other site
634455003230	ATP binding site [chemical binding]; other site
634455003231	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
634455003232	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
634455003233	ABC transporter signature motif; other site
634455003234	Walker B; other site
634455003235	D-loop; other site
634455003236	H-loop/switch region; other site
634455003237	Thioredoxin; Region: Thioredoxin_4; pfam13462
634455003238	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
634455003239	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
634455003240	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634455003241	Transporter associated domain; Region: CorC_HlyC; smart01091
634455003242	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
634455003243	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
634455003244	PhoH-like protein; Region: PhoH; pfam02562
634455003245	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
634455003246	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
634455003247	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455003248	FeS/SAM binding site; other site
634455003249	TRAM domain; Region: TRAM; cl01282
634455003250	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
634455003251	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634455003252	putative acyl-acceptor binding pocket; other site
634455003253	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
634455003254	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634455003255	Surface antigen; Region: Bac_surface_Ag; pfam01103
634455003256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
634455003257	Family of unknown function (DUF490); Region: DUF490; pfam04357
634455003258	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
634455003259	putative catalytic site [active]
634455003260	putative phosphate binding site [ion binding]; other site
634455003261	active site
634455003262	metal binding site A [ion binding]; metal-binding site
634455003263	DNA binding site [nucleotide binding]
634455003264	putative AP binding site [nucleotide binding]; other site
634455003265	putative metal binding site B [ion binding]; other site
634455003266	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
634455003267	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
634455003268	active site
634455003269	dimer interface [polypeptide binding]; other site
634455003270	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
634455003271	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
634455003272	GIY-YIG motif/motif A; other site
634455003273	active site
634455003274	catalytic site [active]
634455003275	putative DNA binding site [nucleotide binding]; other site
634455003276	metal binding site [ion binding]; metal-binding site
634455003277	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
634455003278	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
634455003279	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
634455003280	MoaE interaction surface [polypeptide binding]; other site
634455003281	MoeB interaction surface [polypeptide binding]; other site
634455003282	thiocarboxylated glycine; other site
634455003283	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
634455003284	MoaE homodimer interface [polypeptide binding]; other site
634455003285	MoaD interaction [polypeptide binding]; other site
634455003286	active site residues [active]
634455003287	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
634455003288	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634455003289	inhibitor-cofactor binding pocket; inhibition site
634455003290	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455003291	catalytic residue [active]
634455003292	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
634455003293	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
634455003294	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634455003295	catalytic residue [active]
634455003296	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634455003297	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
634455003298	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455003299	S-adenosylmethionine binding site [chemical binding]; other site
634455003300	AAA domain; Region: AAA_26; pfam13500
634455003301	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
634455003302	LexA repressor; Validated; Region: PRK00215
634455003303	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
634455003304	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634455003305	Catalytic site [active]
634455003306	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
634455003307	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
634455003308	dimer interface [polypeptide binding]; other site
634455003309	putative functional site; other site
634455003310	putative MPT binding site; other site
634455003311	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
634455003312	Septum formation initiator; Region: DivIC; cl17659
634455003313	enolase; Provisional; Region: eno; PRK00077
634455003314	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
634455003315	dimer interface [polypeptide binding]; other site
634455003316	metal binding site [ion binding]; metal-binding site
634455003317	substrate binding pocket [chemical binding]; other site
634455003318	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
634455003319	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
634455003320	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
634455003321	thiS-thiF/thiG interaction site; other site
634455003322	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
634455003323	ThiS interaction site; other site
634455003324	putative active site [active]
634455003325	tetramer interface [polypeptide binding]; other site
634455003326	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
634455003327	thiamine phosphate binding site [chemical binding]; other site
634455003328	active site
634455003329	pyrophosphate binding site [ion binding]; other site
634455003330	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
634455003331	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
634455003332	generic binding surface II; other site
634455003333	ssDNA binding site; other site
634455003334	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455003335	ATP binding site [chemical binding]; other site
634455003336	putative Mg++ binding site [ion binding]; other site
634455003337	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455003338	nucleotide binding region [chemical binding]; other site
634455003339	ATP-binding site [chemical binding]; other site
634455003340	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
634455003341	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
634455003342	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
634455003343	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455003344	ATP binding site [chemical binding]; other site
634455003345	putative Mg++ binding site [ion binding]; other site
634455003346	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455003347	nucleotide binding region [chemical binding]; other site
634455003348	ATP-binding site [chemical binding]; other site
634455003349	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
634455003350	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
634455003351	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
634455003352	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
634455003353	tyrosine decarboxylase; Region: PLN02880
634455003354	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
634455003355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455003356	catalytic residue [active]
634455003357	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
634455003358	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
634455003359	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
634455003360	metal ion-dependent adhesion site (MIDAS); other site
634455003361	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
634455003362	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
634455003363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
634455003364	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634455003365	HSP70 interaction site [polypeptide binding]; other site
634455003366	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
634455003367	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
634455003368	lipoate-protein ligase B; Provisional; Region: PRK14341
634455003369	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
634455003370	active site
634455003371	tetramer interface; other site
634455003372	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
634455003373	active site
634455003374	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
634455003375	substrate binding site [chemical binding]; other site
634455003376	metal binding site [ion binding]; metal-binding site
634455003377	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
634455003378	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455003379	FeS/SAM binding site; other site
634455003380	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
634455003381	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455003382	S-adenosylmethionine binding site [chemical binding]; other site
634455003383	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
634455003384	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634455003385	active site
634455003386	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
634455003387	GSH binding site [chemical binding]; other site
634455003388	catalytic residues [active]
634455003389	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
634455003390	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
634455003391	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
634455003392	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
634455003393	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455003394	S-adenosylmethionine binding site [chemical binding]; other site
634455003395	aspartate kinase; Reviewed; Region: PRK06635
634455003396	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
634455003397	putative nucleotide binding site [chemical binding]; other site
634455003398	putative catalytic residues [active]
634455003399	putative Mg ion binding site [ion binding]; other site
634455003400	putative aspartate binding site [chemical binding]; other site
634455003401	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
634455003402	putative allosteric regulatory site; other site
634455003403	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
634455003404	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
634455003405	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634455003406	FMN binding site [chemical binding]; other site
634455003407	substrate binding site [chemical binding]; other site
634455003408	putative catalytic residue [active]
634455003409	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
634455003410	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455003411	non-specific DNA binding site [nucleotide binding]; other site
634455003412	salt bridge; other site
634455003413	sequence-specific DNA binding site [nucleotide binding]; other site
634455003414	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
634455003415	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
634455003416	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
634455003417	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
634455003418	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
634455003419	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
634455003420	dimer interface [polypeptide binding]; other site
634455003421	motif 1; other site
634455003422	active site
634455003423	motif 2; other site
634455003424	motif 3; other site
634455003425	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
634455003426	anticodon binding site; other site
634455003427	peptide chain release factor 1; Validated; Region: prfA; PRK00591
634455003428	PCRF domain; Region: PCRF; pfam03462
634455003429	RF-1 domain; Region: RF-1; pfam00472
634455003430	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
634455003431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634455003432	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
634455003433	mce related protein; Region: MCE; pfam02470
634455003434	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
634455003435	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
634455003436	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634455003437	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
634455003438	Transglycosylase SLT domain; Region: SLT_2; pfam13406
634455003439	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634455003440	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634455003441	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
634455003442	Sporulation related domain; Region: SPOR; cl10051
634455003443	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
634455003444	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
634455003445	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
634455003446	thymidylate kinase; Validated; Region: tmk; PRK00698
634455003447	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
634455003448	TMP-binding site; other site
634455003449	ATP-binding site [chemical binding]; other site
634455003450	DNA polymerase III subunit delta'; Validated; Region: PRK07471
634455003451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455003452	Walker A motif; other site
634455003453	ATP binding site [chemical binding]; other site
634455003454	Walker B motif; other site
634455003455	arginine finger; other site
634455003456	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
634455003457	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
634455003458	active site
634455003459	HIGH motif; other site
634455003460	KMSKS motif; other site
634455003461	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
634455003462	tRNA binding surface [nucleotide binding]; other site
634455003463	anticodon binding site; other site
634455003464	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
634455003465	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
634455003466	active site
634455003467	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
634455003468	putative hydrolase; Provisional; Region: PRK02113
634455003469	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634455003470	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634455003471	Ligand Binding Site [chemical binding]; other site
634455003472	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
634455003473	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
634455003474	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
634455003475	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
634455003476	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
634455003477	NAD binding site [chemical binding]; other site
634455003478	homotetramer interface [polypeptide binding]; other site
634455003479	homodimer interface [polypeptide binding]; other site
634455003480	substrate binding site [chemical binding]; other site
634455003481	active site
634455003482	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
634455003483	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
634455003484	Tetramer interface [polypeptide binding]; other site
634455003485	active site
634455003486	FMN-binding site [chemical binding]; other site
634455003487	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
634455003488	malate:quinone oxidoreductase; Validated; Region: PRK05257
634455003489	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
634455003490	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
634455003491	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
634455003492	Ligand Binding Site [chemical binding]; other site
634455003493	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
634455003494	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
634455003495	biotin synthase; Region: bioB; TIGR00433
634455003496	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455003497	FeS/SAM binding site; other site
634455003498	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
634455003499	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
634455003500	Domain of unknown function (DUF333); Region: DUF333; pfam03891
634455003501	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
634455003502	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
634455003503	Active Sites [active]
634455003504	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
634455003505	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
634455003506	Active Sites [active]
634455003507	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
634455003508	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
634455003509	G1 box; other site
634455003510	GTP/Mg2+ binding site [chemical binding]; other site
634455003511	G2 box; other site
634455003512	Switch I region; other site
634455003513	G3 box; other site
634455003514	Switch II region; other site
634455003515	G4 box; other site
634455003516	G5 box; other site
634455003517	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
634455003518	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
634455003519	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
634455003520	ligand-binding site [chemical binding]; other site
634455003521	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
634455003522	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
634455003523	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634455003524	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634455003525	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
634455003526	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
634455003527	putative acyl-acceptor binding pocket; other site
634455003528	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
634455003529	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
634455003530	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
634455003531	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
634455003532	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
634455003533	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
634455003534	putative acyl-acceptor binding pocket; other site
634455003535	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634455003536	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
634455003537	active site
634455003538	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
634455003539	putative amphipathic alpha helix; other site
634455003540	YceG-like family; Region: YceG; pfam02618
634455003541	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
634455003542	dimerization interface [polypeptide binding]; other site
634455003543	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
634455003544	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
634455003545	dimer interface [polypeptide binding]; other site
634455003546	active site
634455003547	acyl carrier protein; Provisional; Region: acpP; PRK00982
634455003548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455003549	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
634455003550	NAD(P) binding site [chemical binding]; other site
634455003551	active site
634455003552	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
634455003553	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
634455003554	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
634455003555	putative active site [active]
634455003556	Methyltransferase domain; Region: Methyltransf_31; pfam13847
634455003557	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455003558	S-adenosylmethionine binding site [chemical binding]; other site
634455003559	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
634455003560	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
634455003561	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634455003562	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455003563	catalytic residues [active]
634455003564	catalytic nucleophile [active]
634455003565	Presynaptic Site I dimer interface [polypeptide binding]; other site
634455003566	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634455003567	Synaptic Flat tetramer interface [polypeptide binding]; other site
634455003568	Synaptic Site I dimer interface [polypeptide binding]; other site
634455003569	DNA binding site [nucleotide binding]
634455003570	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455003571	DNA-binding interface [nucleotide binding]; DNA binding site
634455003572	Winged helix-turn helix; Region: HTH_29; pfam13551
634455003573	Helix-turn-helix domain; Region: HTH_28; pfam13518
634455003574	Homeodomain-like domain; Region: HTH_32; pfam13565
634455003575	Integrase core domain; Region: rve; pfam00665
634455003576	Integrase core domain; Region: rve_3; cl15866
634455003577	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
634455003578	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
634455003579	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634455003580	DNA-binding site [nucleotide binding]; DNA binding site
634455003581	RNA-binding motif; other site
634455003582	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634455003583	DNA-binding site [nucleotide binding]; DNA binding site
634455003584	RNA-binding motif; other site
634455003585	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
634455003586	SmpB-tmRNA interface; other site
634455003587	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
634455003588	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
634455003589	dimer interface [polypeptide binding]; other site
634455003590	active site
634455003591	catalytic residue [active]
634455003592	prephenate dehydratase; Provisional; Region: PRK11899
634455003593	Prephenate dehydratase; Region: PDT; pfam00800
634455003594	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
634455003595	putative L-Phe binding site [chemical binding]; other site
634455003596	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
634455003597	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
634455003598	Ligand binding site; other site
634455003599	oligomer interface; other site
634455003600	Cytochrome c; Region: Cytochrom_C; cl11414
634455003601	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634455003602	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
634455003603	active site
634455003604	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
634455003605	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
634455003606	ligand binding site [chemical binding]; other site
634455003607	NAD binding site [chemical binding]; other site
634455003608	tetramer interface [polypeptide binding]; other site
634455003609	catalytic site [active]
634455003610	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
634455003611	L-serine binding site [chemical binding]; other site
634455003612	ACT domain interface; other site
634455003613	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
634455003614	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
634455003615	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
634455003616	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
634455003617	cystathionine beta-lyase; Provisional; Region: PRK05967
634455003618	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
634455003619	homodimer interface [polypeptide binding]; other site
634455003620	substrate-cofactor binding pocket; other site
634455003621	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455003622	catalytic residue [active]
634455003623	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
634455003624	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
634455003625	active site residue [active]
634455003626	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
634455003627	active site residue [active]
634455003628	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634455003629	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634455003630	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
634455003631	putative catalytic site [active]
634455003632	putative metal binding site [ion binding]; other site
634455003633	putative phosphate binding site [ion binding]; other site
634455003634	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
634455003635	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
634455003636	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
634455003637	putative active site [active]
634455003638	catalytic site [active]
634455003639	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
634455003640	putative active site [active]
634455003641	catalytic site [active]
634455003642	hypothetical protein; Reviewed; Region: PRK12497
634455003643	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
634455003644	putative GSH binding site [chemical binding]; other site
634455003645	catalytic residues [active]
634455003646	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
634455003647	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
634455003648	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
634455003649	dimerization interface [polypeptide binding]; other site
634455003650	ATP binding site [chemical binding]; other site
634455003651	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
634455003652	dimerization interface [polypeptide binding]; other site
634455003653	ATP binding site [chemical binding]; other site
634455003654	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
634455003655	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
634455003656	putative active site [active]
634455003657	catalytic triad [active]
634455003658	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
634455003659	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
634455003660	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
634455003661	ATP binding site [chemical binding]; other site
634455003662	active site
634455003663	substrate binding site [chemical binding]; other site
634455003664	adenylosuccinate lyase; Provisional; Region: PRK07492
634455003665	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
634455003666	tetramer interface [polypeptide binding]; other site
634455003667	active site
634455003668	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
634455003669	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
634455003670	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634455003671	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634455003672	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634455003673	catalytic residue [active]
634455003674	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
634455003675	tetramer interfaces [polypeptide binding]; other site
634455003676	binuclear metal-binding site [ion binding]; other site
634455003677	Competence-damaged protein; Region: CinA; pfam02464
634455003678	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
634455003679	putative coenzyme Q binding site [chemical binding]; other site
634455003680	lipoyl synthase; Provisional; Region: PRK05481
634455003681	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455003682	FeS/SAM binding site; other site
634455003683	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
634455003684	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634455003685	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
634455003686	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634455003687	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
634455003688	E3 interaction surface; other site
634455003689	lipoyl attachment site [posttranslational modification]; other site
634455003690	e3 binding domain; Region: E3_binding; pfam02817
634455003691	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
634455003692	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
634455003693	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634455003694	E3 interaction surface; other site
634455003695	lipoyl attachment site [posttranslational modification]; other site
634455003696	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
634455003697	alpha subunit interface [polypeptide binding]; other site
634455003698	TPP binding site [chemical binding]; other site
634455003699	heterodimer interface [polypeptide binding]; other site
634455003700	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634455003701	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
634455003702	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
634455003703	tetramer interface [polypeptide binding]; other site
634455003704	TPP-binding site [chemical binding]; other site
634455003705	heterodimer interface [polypeptide binding]; other site
634455003706	phosphorylation loop region [posttranslational modification]
634455003707	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
634455003708	trimer interface [polypeptide binding]; other site
634455003709	dimer interface [polypeptide binding]; other site
634455003710	putative active site [active]
634455003711	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
634455003712	active site
634455003713	ribulose/triose binding site [chemical binding]; other site
634455003714	phosphate binding site [ion binding]; other site
634455003715	substrate (anthranilate) binding pocket [chemical binding]; other site
634455003716	product (indole) binding pocket [chemical binding]; other site
634455003717	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
634455003718	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
634455003719	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
634455003720	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
634455003721	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
634455003722	glutamine binding [chemical binding]; other site
634455003723	catalytic triad [active]
634455003724	anthranilate synthase component I; Provisional; Region: PRK13573
634455003725	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
634455003726	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
634455003727	SurA N-terminal domain; Region: SurA_N_3; cl07813
634455003728	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
634455003729	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
634455003730	triosephosphate isomerase; Provisional; Region: PRK14565
634455003731	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
634455003732	substrate binding site [chemical binding]; other site
634455003733	dimer interface [polypeptide binding]; other site
634455003734	catalytic triad [active]
634455003735	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
634455003736	CTP synthetase; Validated; Region: pyrG; PRK05380
634455003737	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
634455003738	Catalytic site [active]
634455003739	active site
634455003740	UTP binding site [chemical binding]; other site
634455003741	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
634455003742	active site
634455003743	putative oxyanion hole; other site
634455003744	catalytic triad [active]
634455003745	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
634455003746	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
634455003747	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
634455003748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455003749	ATP binding site [chemical binding]; other site
634455003750	Mg2+ binding site [ion binding]; other site
634455003751	G-X-G motif; other site
634455003752	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
634455003753	anchoring element; other site
634455003754	dimer interface [polypeptide binding]; other site
634455003755	ATP binding site [chemical binding]; other site
634455003756	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
634455003757	active site
634455003758	putative metal-binding site [ion binding]; other site
634455003759	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
634455003760	recombination protein F; Reviewed; Region: recF; PRK00064
634455003761	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455003762	Walker A/P-loop; other site
634455003763	ATP binding site [chemical binding]; other site
634455003764	Q-loop/lid; other site
634455003765	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455003766	ABC transporter signature motif; other site
634455003767	Walker B; other site
634455003768	D-loop; other site
634455003769	H-loop/switch region; other site
634455003770	DNA polymerase III subunit beta; Validated; Region: PRK05643
634455003771	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
634455003772	putative DNA binding surface [nucleotide binding]; other site
634455003773	dimer interface [polypeptide binding]; other site
634455003774	beta-clamp/clamp loader binding surface; other site
634455003775	beta-clamp/translesion DNA polymerase binding surface; other site
634455003776	DnaA N-terminal domain; Region: DnaA_N; pfam11638
634455003777	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
634455003778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455003779	Walker A motif; other site
634455003780	ATP binding site [chemical binding]; other site
634455003781	Walker B motif; other site
634455003782	arginine finger; other site
634455003783	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
634455003784	DnaA box-binding interface [nucleotide binding]; other site
634455003785	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
634455003786	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
634455003787	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
634455003788	DNA binding site [nucleotide binding]
634455003789	catalytic residue [active]
634455003790	H2TH interface [polypeptide binding]; other site
634455003791	putative catalytic residues [active]
634455003792	turnover-facilitating residue; other site
634455003793	intercalation triad [nucleotide binding]; other site
634455003794	8OG recognition residue [nucleotide binding]; other site
634455003795	putative reading head residues; other site
634455003796	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
634455003797	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
634455003798	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455003799	S-adenosylmethionine binding site [chemical binding]; other site
634455003800	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
634455003801	Flavoprotein; Region: Flavoprotein; pfam02441
634455003802	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
634455003803	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
634455003804	trimer interface [polypeptide binding]; other site
634455003805	active site
634455003806	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
634455003807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455003808	dimer interface [polypeptide binding]; other site
634455003809	conserved gate region; other site
634455003810	putative PBP binding loops; other site
634455003811	ABC-ATPase subunit interface; other site
634455003812	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634455003813	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634455003814	Walker A/P-loop; other site
634455003815	ATP binding site [chemical binding]; other site
634455003816	Q-loop/lid; other site
634455003817	ABC transporter signature motif; other site
634455003818	Walker B; other site
634455003819	D-loop; other site
634455003820	H-loop/switch region; other site
634455003821	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
634455003822	methionine sulfoxide reductase A; Provisional; Region: PRK14054
634455003823	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
634455003824	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
634455003825	HIGH motif; other site
634455003826	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
634455003827	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
634455003828	active site
634455003829	KMSKS motif; other site
634455003830	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
634455003831	tRNA binding surface [nucleotide binding]; other site
634455003832	anticodon binding site; other site
634455003833	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
634455003834	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
634455003835	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
634455003836	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
634455003837	Hint domain; Region: Hint_2; pfam13403
634455003838	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
634455003839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455003840	NAD(P) binding site [chemical binding]; other site
634455003841	active site
634455003842	thiamine monophosphate kinase; Provisional; Region: PRK05731
634455003843	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
634455003844	ATP binding site [chemical binding]; other site
634455003845	dimerization interface [polypeptide binding]; other site
634455003846	transcription antitermination factor NusB; Region: nusB; TIGR01951
634455003847	putative RNA binding site [nucleotide binding]; other site
634455003848	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
634455003849	ATP cone domain; Region: ATP-cone; pfam03477
634455003850	Protein of unknown function (DUF461); Region: DUF461; pfam04314
634455003851	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
634455003852	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
634455003853	N- and C-terminal domain interface [polypeptide binding]; other site
634455003854	active site
634455003855	MgATP binding site [chemical binding]; other site
634455003856	catalytic site [active]
634455003857	metal binding site [ion binding]; metal-binding site
634455003858	glycerol binding site [chemical binding]; other site
634455003859	homotetramer interface [polypeptide binding]; other site
634455003860	homodimer interface [polypeptide binding]; other site
634455003861	FBP binding site [chemical binding]; other site
634455003862	protein IIAGlc interface [polypeptide binding]; other site
634455003863	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
634455003864	amphipathic channel; other site
634455003865	Asn-Pro-Ala signature motifs; other site
634455003866	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
634455003867	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
634455003868	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
634455003869	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
634455003870	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
634455003871	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455003872	ATP binding site [chemical binding]; other site
634455003873	putative Mg++ binding site [ion binding]; other site
634455003874	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455003875	nucleotide binding region [chemical binding]; other site
634455003876	ATP-binding site [chemical binding]; other site
634455003877	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
634455003878	HRDC domain; Region: HRDC; pfam00570
634455003879	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634455003880	ligand binding site [chemical binding]; other site
634455003881	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
634455003882	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455003883	Walker A/P-loop; other site
634455003884	ATP binding site [chemical binding]; other site
634455003885	Q-loop/lid; other site
634455003886	ABC transporter signature motif; other site
634455003887	Walker B; other site
634455003888	D-loop; other site
634455003889	H-loop/switch region; other site
634455003890	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
634455003891	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455003892	Walker A/P-loop; other site
634455003893	ATP binding site [chemical binding]; other site
634455003894	Q-loop/lid; other site
634455003895	ABC transporter signature motif; other site
634455003896	Walker B; other site
634455003897	D-loop; other site
634455003898	H-loop/switch region; other site
634455003899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
634455003900	Histidine kinase; Region: HisKA_2; pfam07568
634455003901	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455003902	ATP binding site [chemical binding]; other site
634455003903	Mg2+ binding site [ion binding]; other site
634455003904	G-X-G motif; other site
634455003905	RNA polymerase sigma factor; Provisional; Region: PRK12547
634455003906	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634455003907	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634455003908	DNA binding residues [nucleotide binding]
634455003909	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634455003910	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634455003911	DNA binding residues [nucleotide binding]
634455003912	two-component response regulator; Provisional; Region: PRK09191
634455003913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455003914	active site
634455003915	phosphorylation site [posttranslational modification]
634455003916	intermolecular recognition site; other site
634455003917	dimerization interface [polypeptide binding]; other site
634455003918	ABC transporter ATPase component; Reviewed; Region: PRK11147
634455003919	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634455003920	ABC transporter; Region: ABC_tran_2; pfam12848
634455003921	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634455003922	trehalase; Provisional; Region: treF; PRK13270
634455003923	Trehalase; Region: Trehalase; cl17346
634455003924	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
634455003925	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
634455003926	substrate binding site [chemical binding]; other site
634455003927	catalytic Zn binding site [ion binding]; other site
634455003928	NAD binding site [chemical binding]; other site
634455003929	structural Zn binding site [ion binding]; other site
634455003930	dimer interface [polypeptide binding]; other site
634455003931	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
634455003932	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
634455003933	PhnA protein; Region: PhnA; pfam03831
634455003934	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
634455003935	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
634455003936	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
634455003937	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
634455003938	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
634455003939	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
634455003940	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
634455003941	amidohydrolase; Provisional; Region: PRK12393
634455003942	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
634455003943	active site
634455003944	putative substrate binding pocket [chemical binding]; other site
634455003945	NMT1/THI5 like; Region: NMT1; pfam09084
634455003946	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
634455003947	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634455003948	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634455003949	Walker A/P-loop; other site
634455003950	ATP binding site [chemical binding]; other site
634455003951	Q-loop/lid; other site
634455003952	ABC transporter signature motif; other site
634455003953	Walker B; other site
634455003954	D-loop; other site
634455003955	H-loop/switch region; other site
634455003956	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634455003957	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455003958	dimer interface [polypeptide binding]; other site
634455003959	ABC-ATPase subunit interface; other site
634455003960	putative PBP binding loops; other site
634455003961	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
634455003962	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
634455003963	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
634455003964	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
634455003965	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
634455003966	active site
634455003967	putative substrate binding pocket [chemical binding]; other site
634455003968	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634455003969	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455003970	allantoate amidohydrolase; Reviewed; Region: PRK09290
634455003971	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
634455003972	active site
634455003973	metal binding site [ion binding]; metal-binding site
634455003974	dimer interface [polypeptide binding]; other site
634455003975	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
634455003976	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634455003977	catalytic residue [active]
634455003978	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
634455003979	SnoaL-like domain; Region: SnoaL_3; pfam13474
634455003980	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
634455003981	amidase; Provisional; Region: PRK09201
634455003982	Amidase; Region: Amidase; pfam01425
634455003983	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
634455003984	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
634455003985	XdhC Rossmann domain; Region: XdhC_C; pfam13478
634455003986	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
634455003987	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634455003988	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634455003989	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
634455003990	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634455003991	catalytic loop [active]
634455003992	iron binding site [ion binding]; other site
634455003993	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634455003994	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
634455003995	xanthine permease; Region: pbuX; TIGR03173
634455003996	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
634455003997	active site
634455003998	homotetramer interface [polypeptide binding]; other site
634455003999	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
634455004000	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
634455004001	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
634455004002	active site
634455004003	catalytic site [active]
634455004004	tetramer interface [polypeptide binding]; other site
634455004005	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
634455004006	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
634455004007	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455004008	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455004009	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634455004010	dimerization interface [polypeptide binding]; other site
634455004011	guanine deaminase; Provisional; Region: PRK09228
634455004012	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
634455004013	active site
634455004014	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
634455004015	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
634455004016	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634455004017	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634455004018	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634455004019	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634455004020	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
634455004021	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634455004022	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
634455004023	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634455004024	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455004025	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
634455004026	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
634455004027	Walker A/P-loop; other site
634455004028	ATP binding site [chemical binding]; other site
634455004029	Q-loop/lid; other site
634455004030	ABC transporter signature motif; other site
634455004031	Walker B; other site
634455004032	D-loop; other site
634455004033	H-loop/switch region; other site
634455004034	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455004035	Walker A/P-loop; other site
634455004036	ATP binding site [chemical binding]; other site
634455004037	Q-loop/lid; other site
634455004038	ABC transporter signature motif; other site
634455004039	Walker B; other site
634455004040	D-loop; other site
634455004041	H-loop/switch region; other site
634455004042	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
634455004043	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
634455004044	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
634455004045	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
634455004046	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634455004047	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455004048	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455004049	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
634455004050	putative dimerization interface [polypeptide binding]; other site
634455004051	Predicted membrane protein [Function unknown]; Region: COG2855
634455004052	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
634455004053	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
634455004054	Active site cavity [active]
634455004055	catalytic acid [active]
634455004056	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455004057	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455004058	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455004059	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455004060	WHG domain; Region: WHG; pfam13305
634455004061	Secretory lipase; Region: LIP; pfam03583
634455004062	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
634455004063	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634455004064	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634455004065	NAD(P) binding site [chemical binding]; other site
634455004066	catalytic residues [active]
634455004067	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
634455004068	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
634455004069	FMN binding site [chemical binding]; other site
634455004070	active site
634455004071	substrate binding site [chemical binding]; other site
634455004072	catalytic residue [active]
634455004073	Predicted transcriptional regulators [Transcription]; Region: COG1733
634455004074	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
634455004075	hydroperoxidase II; Provisional; Region: katE; PRK11249
634455004076	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
634455004077	heme binding pocket [chemical binding]; other site
634455004078	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
634455004079	domain interactions; other site
634455004080	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
634455004081	hypothetical protein; Provisional; Region: PRK09256
634455004082	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634455004083	Putative glucoamylase; Region: Glycoamylase; pfam10091
634455004084	Putative glucoamylase; Region: Glycoamylase; pfam10091
634455004085	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
634455004086	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
634455004087	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
634455004088	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
634455004089	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634455004090	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634455004091	active site
634455004092	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
634455004093	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634455004094	Coenzyme A binding pocket [chemical binding]; other site
634455004095	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
634455004096	dimer interface [polypeptide binding]; other site
634455004097	substrate binding site [chemical binding]; other site
634455004098	ATP binding site [chemical binding]; other site
634455004099	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
634455004100	ABC transporter signature motif; other site
634455004101	Walker B; other site
634455004102	D-loop; other site
634455004103	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455004104	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455004105	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
634455004106	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
634455004107	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
634455004108	Protein of unknown function DUF72; Region: DUF72; pfam01904
634455004109	Uncharacterized conserved protein [Function unknown]; Region: COG2135
634455004110	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
634455004111	putative chaperone; Provisional; Region: PRK11678
634455004112	nucleotide binding site [chemical binding]; other site
634455004113	putative NEF/HSP70 interaction site [polypeptide binding]; other site
634455004114	SBD interface [polypeptide binding]; other site
634455004115	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634455004116	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634455004117	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634455004118	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455004119	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
634455004120	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455004121	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455004122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
634455004123	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
634455004124	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
634455004125	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634455004126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004127	putative substrate translocation pore; other site
634455004128	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
634455004129	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
634455004130	active site
634455004131	hypothetical protein; Provisional; Region: PRK09945
634455004132	Hint domain; Region: Hint_2; pfam13403
634455004133	SnoaL-like domain; Region: SnoaL_2; pfam12680
634455004134	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
634455004135	Helix-turn-helix domain; Region: HTH_18; pfam12833
634455004136	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634455004137	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
634455004138	putative deacylase active site [active]
634455004139	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004140	putative substrate translocation pore; other site
634455004141	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634455004142	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
634455004143	metal binding site 2 [ion binding]; metal-binding site
634455004144	putative DNA binding helix; other site
634455004145	metal binding site 1 [ion binding]; metal-binding site
634455004146	dimer interface [polypeptide binding]; other site
634455004147	structural Zn2+ binding site [ion binding]; other site
634455004148	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634455004149	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634455004150	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634455004151	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
634455004152	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
634455004153	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
634455004154	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455004155	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455004156	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455004157	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
634455004158	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
634455004159	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455004160	ligand-binding site [chemical binding]; other site
634455004161	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455004162	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455004163	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455004164	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
634455004165	FecR protein; Region: FecR; pfam04773
634455004166	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634455004167	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
634455004168	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
634455004169	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
634455004170	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455004171	N-terminal plug; other site
634455004172	ligand-binding site [chemical binding]; other site
634455004173	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
634455004174	FecR protein; Region: FecR; pfam04773
634455004175	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004176	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455004177	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
634455004178	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634455004179	DNA binding residues [nucleotide binding]
634455004180	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
634455004181	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
634455004182	substrate binding pocket [chemical binding]; other site
634455004183	membrane-bound complex binding site; other site
634455004184	hinge residues; other site
634455004185	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634455004186	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634455004187	Walker A/P-loop; other site
634455004188	ATP binding site [chemical binding]; other site
634455004189	Q-loop/lid; other site
634455004190	ABC transporter signature motif; other site
634455004191	Walker B; other site
634455004192	D-loop; other site
634455004193	H-loop/switch region; other site
634455004194	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634455004195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455004196	dimer interface [polypeptide binding]; other site
634455004197	conserved gate region; other site
634455004198	putative PBP binding loops; other site
634455004199	ABC-ATPase subunit interface; other site
634455004200	Secretory lipase; Region: LIP; pfam03583
634455004201	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
634455004202	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
634455004203	active site
634455004204	iron coordination sites [ion binding]; other site
634455004205	substrate binding pocket [chemical binding]; other site
634455004206	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455004207	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455004208	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455004209	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455004210	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455004211	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455004212	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
634455004213	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004214	D-galactonate transporter; Region: 2A0114; TIGR00893
634455004215	putative substrate translocation pore; other site
634455004216	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
634455004217	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004218	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004219	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004220	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004221	putative substrate translocation pore; other site
634455004222	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
634455004223	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455004224	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
634455004225	putative dimerization interface [polypeptide binding]; other site
634455004226	putative substrate binding pocket [chemical binding]; other site
634455004227	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
634455004228	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
634455004229	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634455004230	Winged helix-turn helix; Region: HTH_29; pfam13551
634455004231	Integrase core domain; Region: rve; pfam00665
634455004232	Integrase core domain; Region: rve_3; pfam13683
634455004233	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634455004234	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634455004235	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455004236	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455004237	LysR substrate binding domain; Region: LysR_substrate; pfam03466
634455004238	dimerization interface [polypeptide binding]; other site
634455004239	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
634455004240	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
634455004241	putative active site [active]
634455004242	metal binding site [ion binding]; metal-binding site
634455004243	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004244	metabolite-proton symporter; Region: 2A0106; TIGR00883
634455004245	putative substrate translocation pore; other site
634455004246	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
634455004247	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
634455004248	tetrameric interface [polypeptide binding]; other site
634455004249	NAD binding site [chemical binding]; other site
634455004250	catalytic residues [active]
634455004251	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
634455004252	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
634455004253	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634455004254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455004255	dimer interface [polypeptide binding]; other site
634455004256	conserved gate region; other site
634455004257	putative PBP binding loops; other site
634455004258	ABC-ATPase subunit interface; other site
634455004259	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634455004260	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634455004261	Walker A/P-loop; other site
634455004262	ATP binding site [chemical binding]; other site
634455004263	Q-loop/lid; other site
634455004264	ABC transporter signature motif; other site
634455004265	Walker B; other site
634455004266	D-loop; other site
634455004267	H-loop/switch region; other site
634455004268	nickel responsive regulator; Provisional; Region: PRK04460
634455004269	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
634455004270	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
634455004271	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
634455004272	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
634455004273	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
634455004274	urea carboxylase; Region: urea_carbox; TIGR02712
634455004275	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634455004276	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634455004277	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
634455004278	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
634455004279	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
634455004280	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634455004281	carboxyltransferase (CT) interaction site; other site
634455004282	biotinylation site [posttranslational modification]; other site
634455004283	allophanate hydrolase; Provisional; Region: PRK08186
634455004284	Amidase; Region: Amidase; cl11426
634455004285	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634455004286	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634455004287	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
634455004288	Part of AAA domain; Region: AAA_19; pfam13245
634455004289	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
634455004290	AAA domain; Region: AAA_30; pfam13604
634455004291	AAA domain; Region: AAA_12; pfam13087
634455004292	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
634455004293	putative active site [active]
634455004294	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
634455004295	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
634455004296	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634455004297	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
634455004298	active site
634455004299	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455004300	ligand-binding site [chemical binding]; other site
634455004301	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455004302	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455004303	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
634455004304	heme ligand [chemical binding]; other site
634455004305	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455004306	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455004307	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
634455004308	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
634455004309	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
634455004310	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
634455004311	active site
634455004312	non-prolyl cis peptide bond; other site
634455004313	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455004314	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455004315	Flavin Reductases; Region: FlaRed; cl00801
634455004316	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634455004317	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004318	putative substrate translocation pore; other site
634455004319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
634455004320	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
634455004321	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
634455004322	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
634455004323	active site
634455004324	dimer interface [polypeptide binding]; other site
634455004325	non-prolyl cis peptide bond; other site
634455004326	insertion regions; other site
634455004327	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782
634455004328	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
634455004329	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
634455004330	active site
634455004331	non-prolyl cis peptide bond; other site
634455004332	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
634455004333	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634455004334	active site
634455004335	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
634455004336	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
634455004337	putative FMN binding site [chemical binding]; other site
634455004338	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455004339	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004340	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004341	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634455004342	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634455004343	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634455004344	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634455004345	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455004346	ATP binding site [chemical binding]; other site
634455004347	putative Mg++ binding site [ion binding]; other site
634455004348	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004349	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
634455004350	Protein of unknown function DUF45; Region: DUF45; pfam01863
634455004351	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455004352	DNA-binding interface [nucleotide binding]; DNA binding site
634455004353	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455004354	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634455004355	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634455004356	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455004357	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634455004358	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634455004359	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004360	HTH-like domain; Region: HTH_21; pfam13276
634455004361	Integrase core domain; Region: rve; pfam00665
634455004362	Integrase core domain; Region: rve_3; pfam13683
634455004363	Transposase; Region: HTH_Tnp_1; pfam01527
634455004364	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455004365	Walker A/P-loop; other site
634455004366	ATP binding site [chemical binding]; other site
634455004367	Q-loop/lid; other site
634455004368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455004369	ABC transporter signature motif; other site
634455004370	Walker B; other site
634455004371	D-loop; other site
634455004372	H-loop/switch region; other site
634455004373	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455004374	AAA domain; Region: AAA_21; pfam13304
634455004375	Walker A/P-loop; other site
634455004376	ATP binding site [chemical binding]; other site
634455004377	Q-loop/lid; other site
634455004378	ABC transporter signature motif; other site
634455004379	Walker B; other site
634455004380	D-loop; other site
634455004381	H-loop/switch region; other site
634455004382	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
634455004383	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
634455004384	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
634455004385	glutaredoxin 2; Provisional; Region: PRK10387
634455004386	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
634455004387	C-terminal domain interface [polypeptide binding]; other site
634455004388	GSH binding site (G-site) [chemical binding]; other site
634455004389	catalytic residues [active]
634455004390	putative dimer interface [polypeptide binding]; other site
634455004391	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
634455004392	N-terminal domain interface [polypeptide binding]; other site
634455004393	polyol permease family; Region: 2A0118; TIGR00897
634455004394	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004395	putative substrate translocation pore; other site
634455004396	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
634455004397	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
634455004398	active site
634455004399	SAM binding site [chemical binding]; other site
634455004400	homodimer interface [polypeptide binding]; other site
634455004401	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
634455004402	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
634455004403	active site
634455004404	putative homodimer interface [polypeptide binding]; other site
634455004405	SAM binding site [chemical binding]; other site
634455004406	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
634455004407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455004408	S-adenosylmethionine binding site [chemical binding]; other site
634455004409	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
634455004410	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
634455004411	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
634455004412	active site
634455004413	SAM binding site [chemical binding]; other site
634455004414	homodimer interface [polypeptide binding]; other site
634455004415	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
634455004416	active site
634455004417	SAM binding site [chemical binding]; other site
634455004418	homodimer interface [polypeptide binding]; other site
634455004419	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
634455004420	Precorrin-8X methylmutase; Region: CbiC; pfam02570
634455004421	precorrin-3B synthase; Region: CobG; TIGR02435
634455004422	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634455004423	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634455004424	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
634455004425	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
634455004426	fumarate hydratase; Reviewed; Region: fumC; PRK00485
634455004427	Class II fumarases; Region: Fumarase_classII; cd01362
634455004428	active site
634455004429	tetramer interface [polypeptide binding]; other site
634455004430	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
634455004431	GAF domain; Region: GAF; cl17456
634455004432	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
634455004433	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
634455004434	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634455004435	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634455004436	Trp docking motif [polypeptide binding]; other site
634455004437	putative active site [active]
634455004438	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634455004439	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
634455004440	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
634455004441	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
634455004442	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
634455004443	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
634455004444	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
634455004445	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634455004446	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
634455004447	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634455004448	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
634455004449	propionate/acetate kinase; Provisional; Region: PRK12379
634455004450	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
634455004451	phosphate acetyltransferase; Provisional; Region: PRK11890
634455004452	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
634455004453	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
634455004454	phosphate binding site [ion binding]; other site
634455004455	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
634455004456	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
634455004457	dimer interface [polypeptide binding]; other site
634455004458	PYR/PP interface [polypeptide binding]; other site
634455004459	TPP binding site [chemical binding]; other site
634455004460	substrate binding site [chemical binding]; other site
634455004461	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
634455004462	Domain of unknown function; Region: EKR; pfam10371
634455004463	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
634455004464	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
634455004465	TPP-binding site [chemical binding]; other site
634455004466	dimer interface [polypeptide binding]; other site
634455004467	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
634455004468	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634455004469	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634455004470	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
634455004471	Ca2+ binding site [ion binding]; other site
634455004472	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455004473	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455004474	Predicted membrane protein [Function unknown]; Region: COG1971
634455004475	Domain of unknown function DUF; Region: DUF204; pfam02659
634455004476	Domain of unknown function DUF; Region: DUF204; pfam02659
634455004477	glutathionine S-transferase; Provisional; Region: PRK10542
634455004478	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
634455004479	C-terminal domain interface [polypeptide binding]; other site
634455004480	GSH binding site (G-site) [chemical binding]; other site
634455004481	dimer interface [polypeptide binding]; other site
634455004482	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
634455004483	dimer interface [polypeptide binding]; other site
634455004484	N-terminal domain interface [polypeptide binding]; other site
634455004485	substrate binding pocket (H-site) [chemical binding]; other site
634455004486	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
634455004487	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
634455004488	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
634455004489	GTP binding site; other site
634455004490	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
634455004491	Walker A motif; other site
634455004492	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
634455004493	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
634455004494	dimer interface [polypeptide binding]; other site
634455004495	putative functional site; other site
634455004496	putative MPT binding site; other site
634455004497	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
634455004498	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
634455004499	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634455004500	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
634455004501	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
634455004502	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
634455004503	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
634455004504	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
634455004505	[4Fe-4S] binding site [ion binding]; other site
634455004506	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
634455004507	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
634455004508	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
634455004509	molybdopterin cofactor binding site; other site
634455004510	exopolyphosphatase; Region: exo_poly_only; TIGR03706
634455004511	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
634455004512	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
634455004513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455004514	S-adenosylmethionine binding site [chemical binding]; other site
634455004515	fructokinase; Reviewed; Region: PRK09557
634455004516	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634455004517	nucleotide binding site [chemical binding]; other site
634455004518	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
634455004519	CPxP  motif; other site
634455004520	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
634455004521	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
634455004522	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
634455004523	substrate binding pocket [chemical binding]; other site
634455004524	chain length determination region; other site
634455004525	substrate-Mg2+ binding site; other site
634455004526	catalytic residues [active]
634455004527	aspartate-rich region 1; other site
634455004528	active site lid residues [active]
634455004529	aspartate-rich region 2; other site
634455004530	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
634455004531	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
634455004532	TPP-binding site; other site
634455004533	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634455004534	PYR/PP interface [polypeptide binding]; other site
634455004535	dimer interface [polypeptide binding]; other site
634455004536	TPP binding site [chemical binding]; other site
634455004537	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634455004538	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
634455004539	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634455004540	RNA binding surface [nucleotide binding]; other site
634455004541	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455004542	S-adenosylmethionine binding site [chemical binding]; other site
634455004543	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
634455004544	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455004545	FeS/SAM binding site; other site
634455004546	argininosuccinate synthase; Provisional; Region: PRK13820
634455004547	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
634455004548	ANP binding site [chemical binding]; other site
634455004549	Substrate Binding Site II [chemical binding]; other site
634455004550	Substrate Binding Site I [chemical binding]; other site
634455004551	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
634455004552	Cytochrome c; Region: Cytochrom_C; pfam00034
634455004553	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
634455004554	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
634455004555	active site
634455004556	HIGH motif; other site
634455004557	dimer interface [polypeptide binding]; other site
634455004558	KMSKS motif; other site
634455004559	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634455004560	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634455004561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455004562	active site
634455004563	phosphorylation site [posttranslational modification]
634455004564	intermolecular recognition site; other site
634455004565	dimerization interface [polypeptide binding]; other site
634455004566	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455004567	DNA binding site [nucleotide binding]
634455004568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
634455004569	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634455004570	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
634455004571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455004572	S-adenosylmethionine binding site [chemical binding]; other site
634455004573	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
634455004574	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
634455004575	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
634455004576	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
634455004577	active site
634455004578	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
634455004579	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
634455004580	peptide binding site [polypeptide binding]; other site
634455004581	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
634455004582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455004583	dimer interface [polypeptide binding]; other site
634455004584	conserved gate region; other site
634455004585	ABC-ATPase subunit interface; other site
634455004586	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
634455004587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455004588	dimer interface [polypeptide binding]; other site
634455004589	conserved gate region; other site
634455004590	putative PBP binding loops; other site
634455004591	ABC-ATPase subunit interface; other site
634455004592	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
634455004593	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
634455004594	Walker A/P-loop; other site
634455004595	ATP binding site [chemical binding]; other site
634455004596	Q-loop/lid; other site
634455004597	ABC transporter signature motif; other site
634455004598	Walker B; other site
634455004599	D-loop; other site
634455004600	H-loop/switch region; other site
634455004601	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
634455004602	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
634455004603	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
634455004604	Walker A/P-loop; other site
634455004605	ATP binding site [chemical binding]; other site
634455004606	Q-loop/lid; other site
634455004607	ABC transporter signature motif; other site
634455004608	Walker B; other site
634455004609	D-loop; other site
634455004610	H-loop/switch region; other site
634455004611	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
634455004612	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
634455004613	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634455004614	FMN binding site [chemical binding]; other site
634455004615	substrate binding site [chemical binding]; other site
634455004616	putative catalytic residue [active]
634455004617	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
634455004618	active site
634455004619	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
634455004620	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
634455004621	CAS motifs; other site
634455004622	active site
634455004623	Purine nucleoside permease (NUP); Region: NUP; pfam06516
634455004624	Phosphoesterase family; Region: Phosphoesterase; pfam04185
634455004625	Phosphoesterase family; Region: Phosphoesterase; pfam04185
634455004626	Domain of unknown function (DUF756); Region: DUF756; pfam05506
634455004627	Domain of unknown function (DUF756); Region: DUF756; pfam05506
634455004628	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455004629	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455004630	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
634455004631	Tannase and feruloyl esterase; Region: Tannase; pfam07519
634455004632	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634455004633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004634	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634455004635	putative substrate translocation pore; other site
634455004636	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004637	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
634455004638	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
634455004639	FAD binding pocket [chemical binding]; other site
634455004640	FAD binding motif [chemical binding]; other site
634455004641	phosphate binding motif [ion binding]; other site
634455004642	NAD binding pocket [chemical binding]; other site
634455004643	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
634455004644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455004645	S-adenosylmethionine binding site [chemical binding]; other site
634455004646	Predicted transcriptional regulators [Transcription]; Region: COG1695
634455004647	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
634455004648	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455004649	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455004650	multidrug resistance protein MdtN; Provisional; Region: PRK10476
634455004651	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455004652	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455004653	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634455004654	Outer membrane efflux protein; Region: OEP; pfam02321
634455004655	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
634455004656	B12 binding site [chemical binding]; other site
634455004657	Radical SAM superfamily; Region: Radical_SAM; pfam04055
634455004658	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
634455004659	FeS/SAM binding site; other site
634455004660	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
634455004661	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
634455004662	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634455004663	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455004664	N-terminal plug; other site
634455004665	ligand-binding site [chemical binding]; other site
634455004666	Conserved TM helix; Region: TM_helix; pfam05552
634455004667	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634455004668	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
634455004669	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
634455004670	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
634455004671	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
634455004672	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
634455004673	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
634455004674	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455004675	Walker A/P-loop; other site
634455004676	ATP binding site [chemical binding]; other site
634455004677	Q-loop/lid; other site
634455004678	ABC transporter signature motif; other site
634455004679	Walker B; other site
634455004680	D-loop; other site
634455004681	H-loop/switch region; other site
634455004682	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
634455004683	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634455004684	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455004685	Walker A/P-loop; other site
634455004686	ATP binding site [chemical binding]; other site
634455004687	Q-loop/lid; other site
634455004688	ABC transporter signature motif; other site
634455004689	Walker B; other site
634455004690	D-loop; other site
634455004691	H-loop/switch region; other site
634455004692	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
634455004693	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
634455004694	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455004695	N-terminal plug; other site
634455004696	ligand-binding site [chemical binding]; other site
634455004697	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634455004698	Sel1-like repeats; Region: SEL1; smart00671
634455004699	Sel1-like repeats; Region: SEL1; smart00671
634455004700	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455004701	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455004702	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
634455004703	active site
634455004704	homotetramer interface [polypeptide binding]; other site
634455004705	homodimer interface [polypeptide binding]; other site
634455004706	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
634455004707	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455004708	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455004709	homodimer interface [polypeptide binding]; other site
634455004710	catalytic residue [active]
634455004711	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
634455004712	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
634455004713	TrkA-C domain; Region: TrkA_C; pfam02080
634455004714	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
634455004715	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
634455004716	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634455004717	active site
634455004718	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
634455004719	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634455004720	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634455004721	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004722	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
634455004723	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634455004724	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455004725	Walker A/P-loop; other site
634455004726	ATP binding site [chemical binding]; other site
634455004727	Q-loop/lid; other site
634455004728	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634455004729	ABC transporter signature motif; other site
634455004730	Walker B; other site
634455004731	ABC transporter; Region: ABC_tran_2; pfam12848
634455004732	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634455004733	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455004734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455004735	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634455004736	dimerization interface [polypeptide binding]; other site
634455004737	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004738	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
634455004739	Hint domain; Region: Hint_2; pfam13403
634455004740	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455004741	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455004742	N-terminal plug; other site
634455004743	ligand-binding site [chemical binding]; other site
634455004744	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
634455004745	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634455004746	putative NAD(P) binding site [chemical binding]; other site
634455004747	putative substrate binding site [chemical binding]; other site
634455004748	catalytic Zn binding site [ion binding]; other site
634455004749	structural Zn binding site [ion binding]; other site
634455004750	dimer interface [polypeptide binding]; other site
634455004751	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
634455004753	SnoaL-like domain; Region: SnoaL_2; pfam12680
634455004754	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
634455004755	dimerization interface [polypeptide binding]; other site
634455004756	metal binding site [ion binding]; metal-binding site
634455004757	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634455004758	catalytic core [active]
634455004759	MgtC family; Region: MgtC; pfam02308
634455004760	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634455004761	putative CoA-transferase; Provisional; Region: PRK11430
634455004762	CoA-transferase family III; Region: CoA_transf_3; pfam02515
634455004763	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
634455004764	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004765	oxalyl-CoA decarboxylase; Region: oxalate_oxc; TIGR03254
634455004766	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634455004767	PYR/PP interface [polypeptide binding]; other site
634455004768	dimer interface [polypeptide binding]; other site
634455004769	TPP binding site [chemical binding]; other site
634455004770	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634455004771	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
634455004772	TPP-binding site; other site
634455004773	dimer interface [polypeptide binding]; other site
634455004774	formyl-coenzyme A transferase; Provisional; Region: PRK05398
634455004775	CoA-transferase family III; Region: CoA_transf_3; pfam02515
634455004776	oxidoreductase; Provisional; Region: PRK12742
634455004777	classical (c) SDRs; Region: SDR_c; cd05233
634455004778	NAD(P) binding site [chemical binding]; other site
634455004779	active site
634455004780	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455004781	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455004782	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
634455004783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455004784	NAD(P) binding site [chemical binding]; other site
634455004785	active site
634455004786	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
634455004787	putative hydrophobic ligand binding site [chemical binding]; other site
634455004788	protein interface [polypeptide binding]; other site
634455004789	gate; other site
634455004790	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004791	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634455004792	putative substrate translocation pore; other site
634455004793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455004794	phosphoglucomutase; Validated; Region: PRK07564
634455004795	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
634455004796	active site
634455004797	substrate binding site [chemical binding]; other site
634455004798	metal binding site [ion binding]; metal-binding site
634455004799	maltose O-acetyltransferase; Provisional; Region: PRK10092
634455004800	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
634455004801	active site
634455004802	substrate binding site [chemical binding]; other site
634455004803	trimer interface [polypeptide binding]; other site
634455004804	CoA binding site [chemical binding]; other site
634455004805	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
634455004806	Hint domain; Region: Hint_2; pfam13403
634455004807	HTH-like domain; Region: HTH_21; pfam13276
634455004808	Integrase core domain; Region: rve; pfam00665
634455004809	Integrase core domain; Region: rve_3; pfam13683
634455004810	Transposase; Region: HTH_Tnp_1; pfam01527
634455004811	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
634455004812	FecR protein; Region: FecR; pfam04773
634455004813	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
634455004814	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634455004815	DNA binding residues [nucleotide binding]
634455004816	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
634455004817	sensor protein QseC; Provisional; Region: PRK10337
634455004818	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634455004819	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455004820	dimer interface [polypeptide binding]; other site
634455004821	phosphorylation site [posttranslational modification]
634455004822	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634455004823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455004824	active site
634455004825	phosphorylation site [posttranslational modification]
634455004826	intermolecular recognition site; other site
634455004827	dimerization interface [polypeptide binding]; other site
634455004828	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455004829	DNA binding site [nucleotide binding]
634455004830	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634455004831	HlyD family secretion protein; Region: HlyD_2; pfam12700
634455004832	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455004833	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455004834	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634455004835	Outer membrane efflux protein; Region: OEP; pfam02321
634455004836	acyl-CoA synthetase; Validated; Region: PRK09192
634455004837	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
634455004838	acyl-activating enzyme (AAE) consensus motif; other site
634455004839	active site
634455004840	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
634455004841	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
634455004842	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
634455004843	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634455004844	catalytic residue [active]
634455004845	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
634455004846	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
634455004847	active site
634455004848	metal binding site [ion binding]; metal-binding site
634455004849	Predicted permeases [General function prediction only]; Region: COG0795
634455004850	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634455004851	Predicted permeases [General function prediction only]; Region: COG0795
634455004852	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634455004853	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
634455004854	active site
634455004855	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
634455004856	phosphoglycolate phosphatase; Provisional; Region: PRK13222
634455004857	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455004858	motif II; other site
634455004859	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
634455004860	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
634455004861	Substrate binding site; other site
634455004862	Mg++ binding site; other site
634455004863	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
634455004864	active site
634455004865	substrate binding site [chemical binding]; other site
634455004866	CoA binding site [chemical binding]; other site
634455004867	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
634455004868	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
634455004869	glutaminase active site [active]
634455004870	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
634455004871	dimer interface [polypeptide binding]; other site
634455004872	active site
634455004873	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
634455004874	dimer interface [polypeptide binding]; other site
634455004875	active site
634455004876	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455004877	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455004878	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455004879	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455004880	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455004881	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
634455004882	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
634455004883	Transcriptional regulator [Transcription]; Region: IclR; COG1414
634455004884	Bacterial transcriptional regulator; Region: IclR; pfam01614
634455004885	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
634455004886	catalytic residues [active]
634455004887	dimer interface [polypeptide binding]; other site
634455004888	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
634455004889	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
634455004890	Walker A/P-loop; other site
634455004891	ATP binding site [chemical binding]; other site
634455004892	Q-loop/lid; other site
634455004893	ABC transporter signature motif; other site
634455004894	Walker B; other site
634455004895	D-loop; other site
634455004896	H-loop/switch region; other site
634455004897	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
634455004898	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
634455004899	FtsX-like permease family; Region: FtsX; pfam02687
634455004900	prolyl-tRNA synthetase; Provisional; Region: PRK12325
634455004901	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
634455004902	dimer interface [polypeptide binding]; other site
634455004903	motif 1; other site
634455004904	active site
634455004905	motif 2; other site
634455004906	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634455004907	active site
634455004908	motif 3; other site
634455004909	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
634455004910	anticodon binding site; other site
634455004911	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
634455004912	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
634455004913	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
634455004914	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634455004915	nucleotide binding site [chemical binding]; other site
634455004916	Type III pantothenate kinase; Region: Pan_kinase; cl17198
634455004917	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
634455004918	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
634455004919	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
634455004920	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
634455004921	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634455004922	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
634455004923	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
634455004924	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634455004925	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
634455004926	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
634455004927	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
634455004928	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
634455004929	4Fe-4S binding domain; Region: Fer4; cl02805
634455004930	4Fe-4S binding domain; Region: Fer4; pfam00037
634455004931	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
634455004932	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
634455004933	NADH dehydrogenase subunit G; Validated; Region: PRK09130
634455004934	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634455004935	catalytic loop [active]
634455004936	iron binding site [ion binding]; other site
634455004937	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
634455004938	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
634455004939	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
634455004940	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
634455004941	SLBB domain; Region: SLBB; pfam10531
634455004942	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
634455004943	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
634455004944	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
634455004945	putative dimer interface [polypeptide binding]; other site
634455004946	[2Fe-2S] cluster binding site [ion binding]; other site
634455004947	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
634455004948	NADH dehydrogenase subunit D; Validated; Region: PRK06075
634455004949	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
634455004950	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
634455004951	NADH dehydrogenase subunit B; Validated; Region: PRK06411
634455004952	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
634455004953	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634455004954	IHF dimer interface [polypeptide binding]; other site
634455004955	IHF - DNA interface [nucleotide binding]; other site
634455004956	Found in ATP-dependent protease La (LON); Region: LON; smart00464
634455004957	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
634455004958	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455004959	Walker A motif; other site
634455004960	ATP binding site [chemical binding]; other site
634455004961	Walker B motif; other site
634455004962	arginine finger; other site
634455004963	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
634455004964	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
634455004965	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
634455004966	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455004967	Walker A motif; other site
634455004968	ATP binding site [chemical binding]; other site
634455004969	Walker B motif; other site
634455004970	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
634455004971	Clp protease; Region: CLP_protease; pfam00574
634455004972	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
634455004973	oligomer interface [polypeptide binding]; other site
634455004974	active site residues [active]
634455004975	trigger factor; Provisional; Region: tig; PRK01490
634455004976	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
634455004977	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
634455004978	Uncharacterized conserved protein [Function unknown]; Region: COG0062
634455004979	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
634455004980	putative substrate binding site [chemical binding]; other site
634455004981	putative ATP binding site [chemical binding]; other site
634455004982	Predicted integral membrane protein [Function unknown]; Region: COG5615
634455004983	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634455004984	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634455004985	ATP binding site [chemical binding]; other site
634455004986	Mg++ binding site [ion binding]; other site
634455004987	motif III; other site
634455004988	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455004989	nucleotide binding region [chemical binding]; other site
634455004990	ATP-binding site [chemical binding]; other site
634455004991	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
634455004992	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
634455004993	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
634455004994	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
634455004995	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
634455004996	trimerization site [polypeptide binding]; other site
634455004997	active site
634455004998	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
634455004999	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
634455005000	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634455005001	catalytic residue [active]
634455005002	FeS assembly protein SufD; Region: sufD; TIGR01981
634455005003	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
634455005004	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
634455005005	FeS assembly ATPase SufC; Region: sufC; TIGR01978
634455005006	Walker A/P-loop; other site
634455005007	ATP binding site [chemical binding]; other site
634455005008	Q-loop/lid; other site
634455005009	ABC transporter signature motif; other site
634455005010	Walker B; other site
634455005011	D-loop; other site
634455005012	H-loop/switch region; other site
634455005013	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
634455005014	putative ABC transporter; Region: ycf24; CHL00085
634455005015	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
634455005016	Transcriptional regulator; Region: Rrf2; pfam02082
634455005017	Transcriptional regulator; Region: Rrf2; cl17282
634455005018	Protein of unknown function (DUF445); Region: DUF445; pfam04286
634455005019	Peroxin-3; Region: Peroxin-3; pfam04882
634455005020	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
634455005021	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634455005022	elongation factor G; Reviewed; Region: PRK12739
634455005023	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
634455005024	G1 box; other site
634455005025	putative GEF interaction site [polypeptide binding]; other site
634455005026	GTP/Mg2+ binding site [chemical binding]; other site
634455005027	Switch I region; other site
634455005028	G2 box; other site
634455005029	G3 box; other site
634455005030	Switch II region; other site
634455005031	G4 box; other site
634455005032	G5 box; other site
634455005033	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
634455005034	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
634455005035	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
634455005036	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
634455005037	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634455005038	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
634455005039	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
634455005040	Walker A/P-loop; other site
634455005041	ATP binding site [chemical binding]; other site
634455005042	Q-loop/lid; other site
634455005043	ABC transporter signature motif; other site
634455005044	Walker B; other site
634455005045	D-loop; other site
634455005046	H-loop/switch region; other site
634455005047	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
634455005048	nudix motif; other site
634455005049	PII uridylyl-transferase; Provisional; Region: PRK05092
634455005050	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634455005051	metal binding triad; other site
634455005052	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634455005053	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
634455005054	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
634455005055	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
634455005056	MutS domain I; Region: MutS_I; pfam01624
634455005057	MutS domain II; Region: MutS_II; pfam05188
634455005058	MutS domain III; Region: MutS_III; pfam05192
634455005059	MutS domain V; Region: MutS_V; pfam00488
634455005060	Walker A/P-loop; other site
634455005061	ATP binding site [chemical binding]; other site
634455005062	Q-loop/lid; other site
634455005063	ABC transporter signature motif; other site
634455005064	Walker B; other site
634455005065	D-loop; other site
634455005066	H-loop/switch region; other site
634455005067	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
634455005068	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634455005069	binding surface
634455005070	TPR motif; other site
634455005071	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634455005072	binding surface
634455005073	TPR motif; other site
634455005074	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
634455005075	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
634455005076	active site
634455005077	Zn binding site [ion binding]; other site
634455005078	Major royal jelly protein; Region: MRJP; pfam03022
634455005079	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
634455005080	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
634455005081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455005082	catalytic residue [active]
634455005083	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634455005084	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
634455005085	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634455005086	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
634455005087	Tim44-like domain; Region: Tim44; pfam04280
634455005088	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
634455005089	UbiA prenyltransferase family; Region: UbiA; pfam01040
634455005090	cytochrome c oxidase subunit I; Provisional; Region: COX1; MTH00182
634455005091	cytochrome c oxidase subunit I; Provisional; Region: COX1; MTH00182
634455005092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455005093	S-adenosylmethionine binding site [chemical binding]; other site
634455005094	glutathione synthetase; Provisional; Region: PRK05246
634455005095	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
634455005096	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
634455005097	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
634455005098	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
634455005099	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
634455005100	Ligand binding site; other site
634455005101	Putative Catalytic site; other site
634455005102	DXD motif; other site
634455005103	Predicted membrane protein [Function unknown]; Region: COG2246
634455005104	GtrA-like protein; Region: GtrA; pfam04138
634455005105	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634455005106	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
634455005107	putative Zn2+ binding site [ion binding]; other site
634455005108	AsnC family; Region: AsnC_trans_reg; pfam01037
634455005109	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
634455005110	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634455005111	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634455005112	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455005113	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455005114	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634455005115	putative effector binding pocket; other site
634455005116	dimerization interface [polypeptide binding]; other site
634455005117	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
634455005118	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634455005119	IHF - DNA interface [nucleotide binding]; other site
634455005120	IHF dimer interface [polypeptide binding]; other site
634455005121	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
634455005122	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
634455005123	Fe-S cluster binding site [ion binding]; other site
634455005124	active site
634455005125	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
634455005126	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
634455005127	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634455005128	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634455005129	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
634455005130	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
634455005131	DNA binding residues [nucleotide binding]
634455005132	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634455005133	IHF - DNA interface [nucleotide binding]; other site
634455005134	IHF dimer interface [polypeptide binding]; other site
634455005135	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
634455005136	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
634455005137	dimer interface [polypeptide binding]; other site
634455005138	active site
634455005139	CoA binding pocket [chemical binding]; other site
634455005140	putative phosphate acyltransferase; Provisional; Region: PRK05331
634455005141	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
634455005142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
634455005143	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
634455005144	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
634455005145	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
634455005146	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634455005147	dimerization interface [polypeptide binding]; other site
634455005148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455005149	ATP binding site [chemical binding]; other site
634455005150	Mg2+ binding site [ion binding]; other site
634455005151	G-X-G motif; other site
634455005152	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634455005153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455005154	active site
634455005155	phosphorylation site [posttranslational modification]
634455005156	intermolecular recognition site; other site
634455005157	dimerization interface [polypeptide binding]; other site
634455005158	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455005159	DNA binding site [nucleotide binding]
634455005160	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634455005161	MarR family; Region: MarR_2; pfam12802
634455005162	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
634455005163	COQ9; Region: COQ9; pfam08511
634455005164	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
634455005165	active site
634455005166	catalytic residues [active]
634455005167	metal binding site [ion binding]; metal-binding site
634455005168	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
634455005169	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
634455005170	tartrate dehydrogenase; Region: TTC; TIGR02089
634455005171	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
634455005172	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
634455005173	substrate binding site [chemical binding]; other site
634455005174	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
634455005175	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
634455005176	substrate binding site [chemical binding]; other site
634455005177	ligand binding site [chemical binding]; other site
634455005178	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
634455005179	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
634455005180	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
634455005181	RimM N-terminal domain; Region: RimM; pfam01782
634455005182	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
634455005183	signal recognition particle protein; Provisional; Region: PRK10867
634455005184	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
634455005185	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
634455005186	P loop; other site
634455005187	GTP binding site [chemical binding]; other site
634455005188	Signal peptide binding domain; Region: SRP_SPB; pfam02978
634455005189	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
634455005190	dimer interface [polypeptide binding]; other site
634455005191	ATP12 chaperone protein; Region: ATP12; pfam07542
634455005192	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634455005193	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634455005194	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634455005195	RNA binding surface [nucleotide binding]; other site
634455005196	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634455005197	active site
634455005198	recombination factor protein RarA; Reviewed; Region: PRK13342
634455005199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455005200	Walker A motif; other site
634455005201	ATP binding site [chemical binding]; other site
634455005202	Walker B motif; other site
634455005203	arginine finger; other site
634455005204	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
634455005205	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
634455005206	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
634455005207	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
634455005208	UbiA prenyltransferase family; Region: UbiA; pfam01040
634455005209	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
634455005210	RNA methyltransferase, RsmE family; Region: TIGR00046
634455005211	glutamate--cysteine ligase; Region: PLN02611
634455005212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455005213	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634455005214	putative substrate translocation pore; other site
634455005215	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455005216	GTP-binding protein Der; Reviewed; Region: PRK00093
634455005217	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
634455005218	G1 box; other site
634455005219	GTP/Mg2+ binding site [chemical binding]; other site
634455005220	Switch I region; other site
634455005221	G2 box; other site
634455005222	Switch II region; other site
634455005223	G3 box; other site
634455005224	G4 box; other site
634455005225	G5 box; other site
634455005226	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
634455005227	G1 box; other site
634455005228	GTP/Mg2+ binding site [chemical binding]; other site
634455005229	Switch I region; other site
634455005230	G2 box; other site
634455005231	G3 box; other site
634455005232	Switch II region; other site
634455005233	G4 box; other site
634455005234	G5 box; other site
634455005235	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
634455005236	Trp docking motif [polypeptide binding]; other site
634455005237	active site
634455005238	PQQ-like domain; Region: PQQ_2; pfam13360
634455005239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
634455005240	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
634455005241	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
634455005242	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
634455005243	putative active site [active]
634455005244	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
634455005245	putative ADP-binding pocket [chemical binding]; other site
634455005246	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455005247	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
634455005248	active site
634455005249	dimer interface [polypeptide binding]; other site
634455005250	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
634455005251	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
634455005252	Ligand Binding Site [chemical binding]; other site
634455005253	Molecular Tunnel; other site
634455005254	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
634455005255	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
634455005256	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
634455005257	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
634455005258	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
634455005259	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
634455005260	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
634455005261	Sulfate transporter family; Region: Sulfate_transp; pfam00916
634455005262	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
634455005263	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
634455005264	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
634455005265	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
634455005266	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
634455005267	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
634455005268	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
634455005269	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
634455005270	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
634455005271	Clp amino terminal domain; Region: Clp_N; pfam02861
634455005272	Clp amino terminal domain; Region: Clp_N; pfam02861
634455005273	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455005274	Walker A motif; other site
634455005275	ATP binding site [chemical binding]; other site
634455005276	Walker B motif; other site
634455005277	arginine finger; other site
634455005278	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455005279	Walker A motif; other site
634455005280	ATP binding site [chemical binding]; other site
634455005281	Walker B motif; other site
634455005282	arginine finger; other site
634455005283	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
634455005284	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
634455005285	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
634455005286	nudix motif; other site
634455005287	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
634455005288	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
634455005289	HflX GTPase family; Region: HflX; cd01878
634455005290	G1 box; other site
634455005291	GTP/Mg2+ binding site [chemical binding]; other site
634455005292	Switch I region; other site
634455005293	G2 box; other site
634455005294	G3 box; other site
634455005295	Switch II region; other site
634455005296	G4 box; other site
634455005297	G5 box; other site
634455005298	bacterial Hfq-like; Region: Hfq; cd01716
634455005299	hexamer interface [polypeptide binding]; other site
634455005300	Sm1 motif; other site
634455005301	RNA binding site [nucleotide binding]; other site
634455005302	Sm2 motif; other site
634455005303	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
634455005304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455005305	active site
634455005306	phosphorylation site [posttranslational modification]
634455005307	intermolecular recognition site; other site
634455005308	dimerization interface [polypeptide binding]; other site
634455005309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455005310	Walker A motif; other site
634455005311	ATP binding site [chemical binding]; other site
634455005312	Walker B motif; other site
634455005313	arginine finger; other site
634455005314	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
634455005315	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
634455005316	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634455005317	dimerization interface [polypeptide binding]; other site
634455005318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455005319	dimer interface [polypeptide binding]; other site
634455005320	phosphorylation site [posttranslational modification]
634455005321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455005322	ATP binding site [chemical binding]; other site
634455005323	Mg2+ binding site [ion binding]; other site
634455005324	G-X-G motif; other site
634455005325	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
634455005326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455005327	active site
634455005328	phosphorylation site [posttranslational modification]
634455005329	intermolecular recognition site; other site
634455005330	dimerization interface [polypeptide binding]; other site
634455005331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455005332	Walker A motif; other site
634455005333	ATP binding site [chemical binding]; other site
634455005334	Walker B motif; other site
634455005335	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
634455005336	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
634455005337	PAS domain; Region: PAS; smart00091
634455005338	putative active site [active]
634455005339	heme pocket [chemical binding]; other site
634455005340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455005341	dimer interface [polypeptide binding]; other site
634455005342	phosphorylation site [posttranslational modification]
634455005343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455005344	ATP binding site [chemical binding]; other site
634455005345	Mg2+ binding site [ion binding]; other site
634455005346	G-X-G motif; other site
634455005347	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
634455005348	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
634455005349	FMN binding site [chemical binding]; other site
634455005350	active site
634455005351	catalytic residues [active]
634455005352	substrate binding site [chemical binding]; other site
634455005353	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
634455005354	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
634455005355	substrate binding site; other site
634455005356	dimer interface; other site
634455005357	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
634455005358	homotrimer interaction site [polypeptide binding]; other site
634455005359	zinc binding site [ion binding]; other site
634455005360	CDP-binding sites; other site
634455005361	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
634455005362	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
634455005363	Ligand binding site; other site
634455005364	Putative Catalytic site; other site
634455005365	DXD motif; other site
634455005366	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634455005367	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634455005368	active site
634455005369	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
634455005370	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634455005371	UDP-galactopyranose mutase; Region: GLF; pfam03275
634455005372	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
634455005373	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634455005374	active site
634455005375	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
634455005376	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634455005377	active site
634455005378	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455005379	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
634455005380	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634455005381	active site
634455005382	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
634455005383	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
634455005384	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
634455005385	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
634455005386	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
634455005387	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
634455005388	Probable transposase; Region: OrfB_IS605; pfam01385
634455005389	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
634455005390	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
634455005391	Nitrogen regulatory protein P-II; Region: P-II; smart00938
634455005392	serine acetyltransferase; Provisional; Region: cysE; PRK11132
634455005393	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
634455005394	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
634455005395	trimer interface [polypeptide binding]; other site
634455005396	active site
634455005397	substrate binding site [chemical binding]; other site
634455005398	CoA binding site [chemical binding]; other site
634455005399	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634455005400	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
634455005401	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
634455005402	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
634455005403	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
634455005404	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
634455005405	DDE superfamily endonuclease; Region: DDE_5; cl17874
634455005406	elongation factor P; Validated; Region: PRK00529
634455005407	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
634455005408	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
634455005409	RNA binding site [nucleotide binding]; other site
634455005410	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
634455005411	RNA binding site [nucleotide binding]; other site
634455005412	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634455005413	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
634455005414	active site
634455005415	dimerization interface [polypeptide binding]; other site
634455005416	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634455005417	ATP binding site [chemical binding]; other site
634455005418	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
634455005419	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
634455005420	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634455005421	DNA-binding site [nucleotide binding]; DNA binding site
634455005422	RNA-binding motif; other site
634455005423	Dienelactone hydrolase family; Region: DLH; pfam01738
634455005424	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
634455005425	oligomerisation interface [polypeptide binding]; other site
634455005426	mobile loop; other site
634455005427	roof hairpin; other site
634455005428	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
634455005429	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
634455005430	ring oligomerisation interface [polypeptide binding]; other site
634455005431	ATP/Mg binding site [chemical binding]; other site
634455005432	stacking interactions; other site
634455005433	hinge regions; other site
634455005434	FkbH-like domain; Region: FkbH; TIGR01686
634455005435	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455005436	active site
634455005437	motif I; other site
634455005438	motif II; other site
634455005439	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634455005440	Transposase; Region: HTH_Tnp_1; pfam01527
634455005441	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634455005442	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455005443	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634455005444	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455005445	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634455005446	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634455005447	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634455005448	Transposase domain (DUF772); Region: DUF772; pfam05598
634455005449	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455005450	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634455005451	HTH-like domain; Region: HTH_21; pfam13276
634455005452	Integrase core domain; Region: rve; pfam00665
634455005453	Integrase core domain; Region: rve_3; pfam13683
634455005454	Transposase; Region: HTH_Tnp_1; pfam01527
634455005455	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455005456	Transposase domain (DUF772); Region: DUF772; pfam05598
634455005457	GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183
634455005458	Ligand binding site; other site
634455005459	Phosphotransferase enzyme family; Region: APH; pfam01636
634455005460	capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689
634455005461	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455005462	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455005463	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634455005464	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455005465	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
634455005466	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455005467	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455005468	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
634455005469	GDP-Fucose binding site [chemical binding]; other site
634455005470	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
634455005471	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
634455005472	substrate binding site; other site
634455005473	tetramer interface; other site
634455005474	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
634455005475	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
634455005476	NAD binding site [chemical binding]; other site
634455005477	substrate binding site [chemical binding]; other site
634455005478	homodimer interface [polypeptide binding]; other site
634455005479	active site
634455005480	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455005481	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634455005482	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455005483	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455005484	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455005485	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455005486	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455005487	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455005488	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455005489	Transposase domain (DUF772); Region: DUF772; pfam05598
634455005490	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455005491	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634455005492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455005493	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634455005494	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634455005495	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634455005496	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634455005497	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455005498	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634455005499	Transposase; Region: HTH_Tnp_1; pfam01527
634455005500	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634455005501	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
634455005502	active site
634455005503	catalytic triad [active]
634455005504	oxyanion hole [active]
634455005505	Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724
634455005506	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
634455005507	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
634455005508	Aspartyl protease; Region: Asp_protease_2; pfam13650
634455005509	inhibitor binding site; inhibition site
634455005510	catalytic motif [active]
634455005511	Catalytic residue [active]
634455005512	Active site flap [active]
634455005513	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
634455005514	inhibitor binding site; inhibition site
634455005515	catalytic motif [active]
634455005516	Catalytic residue [active]
634455005517	Active site flap [active]
634455005518	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
634455005519	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
634455005520	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455005521	active site
634455005522	DNA binding site [nucleotide binding]
634455005523	Int/Topo IB signature motif; other site
634455005524	primosome assembly protein PriA; Validated; Region: PRK05580
634455005525	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455005526	ATP binding site [chemical binding]; other site
634455005527	putative Mg++ binding site [ion binding]; other site
634455005528	Preprotein translocase subunit; Region: YajC; pfam02699
634455005529	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
634455005530	Protein of unknown function (DUF815); Region: DUF815; pfam05673
634455005531	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634455005532	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634455005533	[2Fe-2S] cluster binding site [ion binding]; other site
634455005534	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
634455005535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634455005536	Coenzyme A binding pocket [chemical binding]; other site
634455005537	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
634455005538	active site
634455005539	8-oxo-dGMP binding site [chemical binding]; other site
634455005540	nudix motif; other site
634455005541	metal binding site [ion binding]; metal-binding site
634455005542	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
634455005543	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
634455005544	Substrate binding site; other site
634455005545	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
634455005546	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
634455005547	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
634455005548	homodimer interface [polypeptide binding]; other site
634455005549	substrate-cofactor binding pocket; other site
634455005550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455005551	catalytic residue [active]
634455005552	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
634455005553	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
634455005554	GTP cyclohydrolase I; Provisional; Region: PLN03044
634455005555	active site
634455005556	intracellular protease, PfpI family; Region: PfpI; TIGR01382
634455005557	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
634455005558	conserved cys residue [active]
634455005559	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
634455005560	MPT binding site; other site
634455005561	trimer interface [polypeptide binding]; other site
634455005562	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634455005563	Uncharacterized conserved protein [Function unknown]; Region: COG4717
634455005564	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
634455005565	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
634455005566	active site
634455005567	metal binding site [ion binding]; metal-binding site
634455005568	DNA binding site [nucleotide binding]
634455005569	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634455005570	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
634455005571	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
634455005572	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634455005573	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455005574	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455005575	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
634455005576	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
634455005577	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
634455005578	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
634455005579	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
634455005580	homopentamer interface [polypeptide binding]; other site
634455005581	active site
634455005582	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
634455005583	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
634455005584	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
634455005585	dimerization interface [polypeptide binding]; other site
634455005586	active site
634455005587	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
634455005588	Lumazine binding domain; Region: Lum_binding; pfam00677
634455005589	Lumazine binding domain; Region: Lum_binding; pfam00677
634455005590	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
634455005591	catalytic motif [active]
634455005592	Zn binding site [ion binding]; other site
634455005593	RibD C-terminal domain; Region: RibD_C; cl17279
634455005594	cytochrome b; Provisional; Region: CYTB; MTH00145
634455005595	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634455005596	Qi binding site; other site
634455005597	intrachain domain interface; other site
634455005598	interchain domain interface [polypeptide binding]; other site
634455005599	heme bH binding site [chemical binding]; other site
634455005600	heme bL binding site [chemical binding]; other site
634455005601	Qo binding site; other site
634455005602	interchain domain interface [polypeptide binding]; other site
634455005603	intrachain domain interface; other site
634455005604	Qi binding site; other site
634455005605	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
634455005606	Qo binding site; other site
634455005607	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
634455005608	Cytochrome c; Region: Cytochrom_C; cl11414
634455005609	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
634455005610	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
634455005611	[2Fe-2S] cluster binding site [ion binding]; other site
634455005612	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
634455005613	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
634455005614	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634455005615	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
634455005616	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634455005617	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634455005618	Hint domain; Region: Hint_2; pfam13403
634455005619	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455005620	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
634455005621	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455005622	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
634455005623	Predicted helicase [General function prediction only]; Region: COG4889
634455005624	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455005625	ATP binding site [chemical binding]; other site
634455005626	putative Mg++ binding site [ion binding]; other site
634455005627	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
634455005628	ATP-binding site [chemical binding]; other site
634455005629	Protein of unknown function DUF262; Region: DUF262; pfam03235
634455005630	Uncharacterized conserved protein [Function unknown]; Region: COG1479
634455005631	Protein of unknown function DUF262; Region: DUF262; pfam03235
634455005632	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
634455005633	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
634455005634	HTH-like domain; Region: HTH_21; pfam13276
634455005635	Integrase core domain; Region: rve; pfam00665
634455005636	Integrase core domain; Region: rve_3; pfam13683
634455005637	Transposase; Region: HTH_Tnp_1; pfam01527
634455005638	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
634455005639	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
634455005640	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
634455005641	GTPase CgtA; Reviewed; Region: obgE; PRK12299
634455005642	GTP1/OBG; Region: GTP1_OBG; pfam01018
634455005643	Obg GTPase; Region: Obg; cd01898
634455005644	G1 box; other site
634455005645	GTP/Mg2+ binding site [chemical binding]; other site
634455005646	Switch I region; other site
634455005647	G2 box; other site
634455005648	G3 box; other site
634455005649	Switch II region; other site
634455005650	G4 box; other site
634455005651	G5 box; other site
634455005652	gamma-glutamyl kinase; Provisional; Region: PRK05429
634455005653	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
634455005654	nucleotide binding site [chemical binding]; other site
634455005655	homotetrameric interface [polypeptide binding]; other site
634455005656	putative phosphate binding site [ion binding]; other site
634455005657	putative allosteric binding site; other site
634455005658	PUA domain; Region: PUA; pfam01472
634455005659	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
634455005660	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
634455005661	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
634455005662	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
634455005663	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634455005664	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634455005665	substrate binding pocket [chemical binding]; other site
634455005666	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
634455005667	cell division protein MraZ; Reviewed; Region: PRK00326
634455005668	MraZ protein; Region: MraZ; pfam02381
634455005669	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
634455005670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455005671	S-adenosylmethionine binding site [chemical binding]; other site
634455005672	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
634455005673	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
634455005674	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
634455005675	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
634455005676	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
634455005677	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634455005678	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634455005679	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634455005680	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
634455005681	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634455005682	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634455005683	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634455005684	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
634455005685	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
634455005686	Mg++ binding site [ion binding]; other site
634455005687	putative catalytic motif [active]
634455005688	putative substrate binding site [chemical binding]; other site
634455005689	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
634455005690	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634455005691	cell division protein FtsW; Region: ftsW; TIGR02614
634455005692	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
634455005693	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
634455005694	active site
634455005695	homodimer interface [polypeptide binding]; other site
634455005696	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
634455005697	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634455005698	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634455005699	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634455005700	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
634455005701	FAD binding domain; Region: FAD_binding_4; pfam01565
634455005702	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
634455005703	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
634455005704	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
634455005705	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634455005706	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
634455005707	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
634455005708	Cell division protein FtsQ; Region: FtsQ; pfam03799
634455005709	Cell division protein FtsA; Region: FtsA; smart00842
634455005710	cell division protein FtsA; Region: ftsA; TIGR01174
634455005711	Cell division protein FtsA; Region: FtsA; pfam14450
634455005712	cell division protein FtsZ; Validated; Region: PRK09330
634455005713	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
634455005714	nucleotide binding site [chemical binding]; other site
634455005715	SulA interaction site; other site
634455005716	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
634455005717	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
634455005718	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
634455005719	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
634455005720	binding surface
634455005721	TPR motif; other site
634455005722	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
634455005723	Walker A/P-loop; other site
634455005724	ATP binding site [chemical binding]; other site
634455005725	Q-loop/lid; other site
634455005726	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
634455005727	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
634455005728	ABC transporter signature motif; other site
634455005729	Walker B; other site
634455005730	D-loop; other site
634455005731	H-loop/switch region; other site
634455005732	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
634455005733	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
634455005734	nucleotide binding pocket [chemical binding]; other site
634455005735	K-X-D-G motif; other site
634455005736	catalytic site [active]
634455005737	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
634455005738	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
634455005739	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
634455005740	Dimer interface [polypeptide binding]; other site
634455005741	BRCT sequence motif; other site
634455005742	pyruvate phosphate dikinase; Provisional; Region: PRK09279
634455005743	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
634455005744	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
634455005745	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
634455005746	PEP synthetase regulatory protein; Provisional; Region: PRK05339
634455005747	Uncharacterized conserved protein [Function unknown]; Region: COG1739
634455005748	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
634455005749	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
634455005750	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
634455005751	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
634455005752	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
634455005753	active site
634455005754	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
634455005755	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634455005756	active site
634455005757	HIGH motif; other site
634455005758	nucleotide binding site [chemical binding]; other site
634455005759	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
634455005760	active site
634455005761	KMSKS motif; other site
634455005762	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
634455005763	Isochorismatase family; Region: Isochorismatase; pfam00857
634455005764	catalytic triad [active]
634455005765	metal binding site [ion binding]; metal-binding site
634455005766	conserved cis-peptide bond; other site
634455005767	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
634455005768	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634455005769	metal-binding site [ion binding]
634455005770	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
634455005771	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634455005772	metal-binding site [ion binding]
634455005773	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634455005774	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455005775	motif II; other site
634455005776	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
634455005777	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
634455005778	Multicopper oxidase; Region: Cu-oxidase; pfam00394
634455005779	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
634455005780	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
634455005781	ketol-acid reductoisomerase; Provisional; Region: PRK05479
634455005782	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
634455005783	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
634455005784	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
634455005785	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
634455005786	putative valine binding site [chemical binding]; other site
634455005787	dimer interface [polypeptide binding]; other site
634455005788	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
634455005789	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
634455005790	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634455005791	PYR/PP interface [polypeptide binding]; other site
634455005792	dimer interface [polypeptide binding]; other site
634455005793	TPP binding site [chemical binding]; other site
634455005794	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634455005795	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
634455005796	TPP-binding site [chemical binding]; other site
634455005797	dimer interface [polypeptide binding]; other site
634455005798	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
634455005799	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
634455005800	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
634455005801	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455005802	motif II; other site
634455005803	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
634455005804	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
634455005805	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634455005806	ATP binding site [chemical binding]; other site
634455005807	putative Mg++ binding site [ion binding]; other site
634455005808	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455005809	nucleotide binding region [chemical binding]; other site
634455005810	ATP-binding site [chemical binding]; other site
634455005811	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455005812	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634455005813	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455005814	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634455005815	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
634455005816	active site
634455005817	Zn binding site [ion binding]; other site
634455005818	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
634455005819	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
634455005820	dimer interface [polypeptide binding]; other site
634455005821	active site
634455005822	glycine-pyridoxal phosphate binding site [chemical binding]; other site
634455005823	folate binding site [chemical binding]; other site
634455005824	amino acid transporter; Region: 2A0306; TIGR00909
634455005825	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
634455005826	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
634455005827	dimer interface [polypeptide binding]; other site
634455005828	allosteric magnesium binding site [ion binding]; other site
634455005829	active site
634455005830	aspartate-rich active site metal binding site; other site
634455005831	Schiff base residues; other site
634455005832	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
634455005833	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
634455005834	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
634455005835	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
634455005836	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
634455005837	CAP-like domain; other site
634455005838	active site
634455005839	primary dimer interface [polypeptide binding]; other site
634455005840	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
634455005841	Recombination protein O N terminal; Region: RecO_N; pfam11967
634455005842	Recombination protein O C terminal; Region: RecO_C; pfam02565
634455005843	elongation factor Ts; Provisional; Region: tsf; PRK09377
634455005844	UBA/TS-N domain; Region: UBA; pfam00627
634455005845	Elongation factor TS; Region: EF_TS; pfam00889
634455005846	Elongation factor TS; Region: EF_TS; pfam00889
634455005847	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
634455005848	rRNA interaction site [nucleotide binding]; other site
634455005849	S8 interaction site; other site
634455005850	putative laminin-1 binding site; other site
634455005851	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634455005852	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634455005853	[2Fe-2S] cluster binding site [ion binding]; other site
634455005854	Selenoprotein P, N terminal region; Region: SelP_N; pfam04592
634455005855	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
634455005856	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
634455005857	homodimer interface [polypeptide binding]; other site
634455005858	substrate-cofactor binding pocket; other site
634455005859	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455005860	catalytic residue [active]
634455005861	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
634455005862	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
634455005863	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
634455005864	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
634455005865	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
634455005866	putative active site [active]
634455005867	putative PHP Thumb interface [polypeptide binding]; other site
634455005868	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
634455005869	generic binding surface II; other site
634455005870	generic binding surface I; other site
634455005871	Pantoate-beta-alanine ligase; Region: PanC; cd00560
634455005872	pantoate--beta-alanine ligase; Region: panC; TIGR00018
634455005873	active site
634455005874	ATP-binding site [chemical binding]; other site
634455005875	pantoate-binding site; other site
634455005876	HXXH motif; other site
634455005877	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
634455005878	homotrimer interaction site [polypeptide binding]; other site
634455005879	putative active site [active]
634455005880	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
634455005881	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
634455005882	aspartate aminotransferase; Provisional; Region: PRK05764
634455005883	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455005884	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455005885	homodimer interface [polypeptide binding]; other site
634455005886	catalytic residue [active]
634455005887	aspartate aminotransferase; Provisional; Region: PRK05764
634455005888	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455005889	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455005890	homodimer interface [polypeptide binding]; other site
634455005891	catalytic residue [active]
634455005892	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
634455005893	active site
634455005894	HIGH motif; other site
634455005895	nucleotide binding site [chemical binding]; other site
634455005896	active site
634455005897	KMSKS motif; other site
634455005898	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
634455005899	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
634455005900	active site
634455005901	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634455005902	metal-binding site [ion binding]
634455005903	hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367
634455005904	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
634455005905	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455005906	FeS/SAM binding site; other site
634455005907	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
634455005908	active site
634455005909	multimer interface [polypeptide binding]; other site
634455005910	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
634455005911	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455005912	Walker A/P-loop; other site
634455005913	ATP binding site [chemical binding]; other site
634455005914	Q-loop/lid; other site
634455005915	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634455005916	ABC transporter; Region: ABC_tran_2; pfam12848
634455005917	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634455005918	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634455005919	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634455005920	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634455005921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455005922	active site
634455005923	phosphorylation site [posttranslational modification]
634455005924	intermolecular recognition site; other site
634455005925	dimerization interface [polypeptide binding]; other site
634455005926	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455005927	DNA binding site [nucleotide binding]
634455005928	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634455005929	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
634455005930	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
634455005931	dimer interface [polypeptide binding]; other site
634455005932	phosphorylation site [posttranslational modification]
634455005933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455005934	ATP binding site [chemical binding]; other site
634455005935	Mg2+ binding site [ion binding]; other site
634455005936	G-X-G motif; other site
634455005937	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
634455005938	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
634455005939	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
634455005940	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
634455005941	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
634455005942	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
634455005943	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
634455005944	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
634455005945	active site
634455005946	dimer interface [polypeptide binding]; other site
634455005947	motif 1; other site
634455005948	motif 2; other site
634455005949	motif 3; other site
634455005950	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
634455005951	anticodon binding site; other site
634455005952	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
634455005953	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
634455005954	putative active site [active]
634455005955	TPR repeat; Region: TPR_11; pfam13414
634455005956	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634455005957	binding surface
634455005958	TPR motif; other site
634455005959	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455005960	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
634455005961	putative ADP-binding pocket [chemical binding]; other site
634455005962	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
634455005963	ATP-NAD kinase; Region: NAD_kinase; pfam01513
634455005964	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
634455005965	RNA/DNA hybrid binding site [nucleotide binding]; other site
634455005966	active site
634455005967	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
634455005968	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
634455005969	putative active site [active]
634455005970	putative substrate binding site [chemical binding]; other site
634455005971	ATP binding site [chemical binding]; other site
634455005972	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
634455005973	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
634455005974	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
634455005975	ABC1 family; Region: ABC1; cl17513
634455005976	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
634455005977	active site
634455005978	substrate binding site [chemical binding]; other site
634455005979	ATP binding site [chemical binding]; other site
634455005980	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
634455005981	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
634455005982	active site
634455005983	Zn binding site [ion binding]; other site
634455005984	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
634455005985	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
634455005986	active site
634455005987	dimer interface [polypeptide binding]; other site
634455005988	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
634455005989	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
634455005990	active site
634455005991	FMN binding site [chemical binding]; other site
634455005992	substrate binding site [chemical binding]; other site
634455005993	3Fe-4S cluster binding site [ion binding]; other site
634455005994	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
634455005995	domain interface; other site
634455005996	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
634455005997	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634455005998	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634455005999	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
634455006000	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
634455006001	putative NAD(P) binding site [chemical binding]; other site
634455006002	active site
634455006003	EamA-like transporter family; Region: EamA; pfam00892
634455006004	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634455006005	EamA-like transporter family; Region: EamA; pfam00892
634455006006	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
634455006007	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
634455006008	active site
634455006009	metal binding site [ion binding]; metal-binding site
634455006010	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
634455006011	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
634455006012	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
634455006013	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
634455006014	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
634455006015	histidinol dehydrogenase; Region: hisD; TIGR00069
634455006016	NAD binding site [chemical binding]; other site
634455006017	dimerization interface [polypeptide binding]; other site
634455006018	product binding site; other site
634455006019	substrate binding site [chemical binding]; other site
634455006020	zinc binding site [ion binding]; other site
634455006021	catalytic residues [active]
634455006022	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
634455006023	rRNA binding site [nucleotide binding]; other site
634455006024	predicted 30S ribosome binding site; other site
634455006025	Maf-like protein; Region: Maf; pfam02545
634455006026	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
634455006027	active site
634455006028	dimer interface [polypeptide binding]; other site
634455006029	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
634455006030	RNA binding site [nucleotide binding]; other site
634455006031	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
634455006032	Domain of unknown function (DUF329); Region: DUF329; pfam03884
634455006033	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
634455006034	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
634455006035	catalytic residue [active]
634455006036	protease 2; Provisional; Region: PRK10115
634455006037	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
634455006038	Phage capsid family; Region: Phage_capsid; pfam05065
634455006039	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
634455006040	Phage-related protein [Function unknown]; Region: COG4695
634455006041	Phage portal protein; Region: Phage_portal; pfam04860
634455006042	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
634455006043	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
634455006044	active site
634455006045	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
634455006046	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
634455006047	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455006048	active site
634455006049	DNA binding site [nucleotide binding]
634455006050	Int/Topo IB signature motif; other site
634455006051	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
634455006052	Prophage antirepressor [Transcription]; Region: COG3617
634455006053	BRO family, N-terminal domain; Region: Bro-N; smart01040
634455006054	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
634455006055	Predicted transcriptional regulator [Transcription]; Region: COG2932
634455006056	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634455006057	Catalytic site [active]
634455006058	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
634455006059	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
634455006060	active site
634455006061	catalytic site [active]
634455006062	substrate binding site [chemical binding]; other site
634455006063	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455006064	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634455006065	non-specific DNA binding site [nucleotide binding]; other site
634455006066	salt bridge; other site
634455006067	sequence-specific DNA binding site [nucleotide binding]; other site
634455006068	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634455006069	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455006070	active site
634455006071	DNA binding site [nucleotide binding]
634455006072	Int/Topo IB signature motif; other site
634455006073	Cytochrome c; Region: Cytochrom_C; pfam00034
634455006074	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
634455006075	homotetramer interface [polypeptide binding]; other site
634455006076	short chain dehydrogenase; Validated; Region: PRK07069
634455006077	NAD binding site [chemical binding]; other site
634455006078	homodimer interface [polypeptide binding]; other site
634455006079	active site
634455006080	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
634455006081	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634455006082	NAD binding site [chemical binding]; other site
634455006083	catalytic residues [active]
634455006084	D-lactate dehydrogenase; Provisional; Region: PRK11183
634455006085	FAD binding domain; Region: FAD_binding_4; pfam01565
634455006086	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
634455006087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
634455006088	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
634455006089	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
634455006090	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
634455006091	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
634455006092	Uncharacterized conserved protein [Function unknown]; Region: COG2308
634455006093	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
634455006094	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
634455006095	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
634455006096	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
634455006097	dimerization interface [polypeptide binding]; other site
634455006098	active site
634455006099	quinolinate synthetase; Provisional; Region: PRK09375
634455006100	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
634455006101	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455006102	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455006103	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
634455006104	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634455006105	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634455006106	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634455006107	NAD(P) binding site [chemical binding]; other site
634455006108	catalytic residues [active]
634455006109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455006110	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634455006111	putative substrate translocation pore; other site
634455006112	Domain of unknown function (DUF336); Region: DUF336; pfam03928
634455006113	Predicted flavoprotein [General function prediction only]; Region: COG0431
634455006114	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
634455006115	Pirin-related protein [General function prediction only]; Region: COG1741
634455006116	Pirin; Region: Pirin; pfam02678
634455006117	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
634455006118	LysR family transcriptional regulator; Provisional; Region: PRK14997
634455006119	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455006120	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
634455006121	putative effector binding pocket; other site
634455006122	putative dimerization interface [polypeptide binding]; other site
634455006123	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634455006124	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634455006125	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634455006126	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634455006127	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
634455006128	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634455006129	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455006130	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634455006131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455006132	D-galactonate transporter; Region: 2A0114; TIGR00893
634455006133	putative substrate translocation pore; other site
634455006134	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634455006135	EamA-like transporter family; Region: EamA; cl17759
634455006136	EamA-like transporter family; Region: EamA; pfam00892
634455006137	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
634455006138	putative active site [active]
634455006139	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
634455006140	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
634455006141	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
634455006142	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
634455006143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455006144	NAD(P) binding site [chemical binding]; other site
634455006145	active site
634455006146	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
634455006147	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634455006148	carboxyltransferase (CT) interaction site; other site
634455006149	biotinylation site [posttranslational modification]; other site
634455006150	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
634455006151	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634455006152	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
634455006153	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
634455006154	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
634455006155	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634455006156	carboxyltransferase (CT) interaction site; other site
634455006157	biotinylation site [posttranslational modification]; other site
634455006158	aspartate aminotransferase; Provisional; Region: PRK05764
634455006159	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455006160	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455006161	homodimer interface [polypeptide binding]; other site
634455006162	catalytic residue [active]
634455006163	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
634455006164	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455006165	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
634455006166	putative dimerization interface [polypeptide binding]; other site
634455006167	amidase; Provisional; Region: PRK07056
634455006168	Amidase; Region: Amidase; cl11426
634455006169	short chain dehydrogenase; Provisional; Region: PRK09291
634455006170	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455006171	NAD(P) binding site [chemical binding]; other site
634455006172	active site
634455006173	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
634455006174	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
634455006175	active site
634455006176	catalytic site [active]
634455006177	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
634455006178	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
634455006179	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
634455006180	catalytic site [active]
634455006181	active site
634455006182	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
634455006183	glycogen branching enzyme; Provisional; Region: PRK05402
634455006184	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
634455006185	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
634455006186	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
634455006187	active site
634455006188	catalytic site [active]
634455006189	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
634455006190	glycogen synthase; Provisional; Region: glgA; PRK00654
634455006191	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
634455006192	ADP-binding pocket [chemical binding]; other site
634455006193	homodimer interface [polypeptide binding]; other site
634455006194	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
634455006195	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
634455006196	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
634455006197	active site
634455006198	catalytic site [active]
634455006199	short chain dehydrogenase; Provisional; Region: PRK06701
634455006200	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455006201	NAD(P) binding site [chemical binding]; other site
634455006202	active site
634455006203	thiamine pyrophosphate protein; Provisional; Region: PRK08273
634455006204	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
634455006205	PYR/PP interface [polypeptide binding]; other site
634455006206	dimer interface [polypeptide binding]; other site
634455006207	tetramer interface [polypeptide binding]; other site
634455006208	TPP binding site [chemical binding]; other site
634455006209	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634455006210	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
634455006211	TPP-binding site [chemical binding]; other site
634455006212	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634455006213	Transposase; Region: HTH_Tnp_1; pfam01527
634455006214	HTH-like domain; Region: HTH_21; pfam13276
634455006215	Integrase core domain; Region: rve; pfam00665
634455006216	Integrase core domain; Region: rve_3; pfam13683
634455006217	FAD binding domain; Region: FAD_binding_3; pfam01494
634455006218	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634455006219	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
634455006220	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
634455006221	Cu(I) binding site [ion binding]; other site
634455006222	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455006223	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455006224	N-terminal plug; other site
634455006225	ligand-binding site [chemical binding]; other site
634455006226	Hint domain; Region: Hint_2; pfam13403
634455006227	HTH-like domain; Region: HTH_21; pfam13276
634455006228	Integrase core domain; Region: rve; pfam00665
634455006229	Integrase core domain; Region: rve_3; pfam13683
634455006230	Transposase; Region: HTH_Tnp_1; pfam01527
634455006231	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
634455006232	nudix motif; other site
634455006233	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455006234	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634455006235	dimerization interface [polypeptide binding]; other site
634455006236	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634455006237	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634455006238	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
634455006239	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
634455006240	Zinc-finger domain; Region: zf-CHCC; pfam10276
634455006241	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
634455006242	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
634455006243	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
634455006244	DsbD alpha interface [polypeptide binding]; other site
634455006245	catalytic residues [active]
634455006246	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
634455006247	seryl-tRNA synthetase; Provisional; Region: PRK05431
634455006248	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
634455006249	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
634455006250	dimer interface [polypeptide binding]; other site
634455006251	active site
634455006252	motif 1; other site
634455006253	motif 2; other site
634455006254	motif 3; other site
634455006255	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
634455006256	sec-independent translocase; Provisional; Region: tatB; PRK00182
634455006257	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
634455006258	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
634455006259	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
634455006260	Sporulation related domain; Region: SPOR; pfam05036
634455006261	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
634455006262	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
634455006263	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634455006264	active site
634455006265	HIGH motif; other site
634455006266	nucleotide binding site [chemical binding]; other site
634455006267	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
634455006268	KMSK motif region; other site
634455006269	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
634455006270	tRNA binding surface [nucleotide binding]; other site
634455006271	anticodon binding site; other site
634455006272	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
634455006273	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
634455006274	Zn2+ binding site [ion binding]; other site
634455006275	Mg2+ binding site [ion binding]; other site
634455006276	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
634455006277	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
634455006278	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
634455006279	putative catalytic site [active]
634455006280	putative phosphate binding site [ion binding]; other site
634455006281	active site
634455006282	metal binding site A [ion binding]; metal-binding site
634455006283	DNA binding site [nucleotide binding]
634455006284	putative AP binding site [nucleotide binding]; other site
634455006285	putative metal binding site B [ion binding]; other site
634455006286	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634455006287	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634455006288	active site
634455006289	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
634455006290	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
634455006291	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
634455006292	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
634455006293	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
634455006294	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
634455006295	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
634455006296	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
634455006297	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
634455006298	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
634455006299	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455006300	FeS/SAM binding site; other site
634455006301	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
634455006302	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
634455006303	dinuclear metal binding motif [ion binding]; other site
634455006304	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
634455006305	Clp protease; Region: CLP_protease; pfam00574
634455006306	oligomer interface [polypeptide binding]; other site
634455006307	active site residues [active]
634455006308	aminotransferase; Validated; Region: PRK09148
634455006309	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455006310	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455006311	homodimer interface [polypeptide binding]; other site
634455006312	catalytic residue [active]
634455006313	homoserine dehydrogenase; Provisional; Region: PRK06349
634455006314	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
634455006315	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
634455006316	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
634455006317	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
634455006318	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
634455006319	putative active site [active]
634455006320	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
634455006321	DHH family; Region: DHH; pfam01368
634455006322	DHHA1 domain; Region: DHHA1; pfam02272
634455006323	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
634455006324	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634455006325	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634455006326	DNA binding residues [nucleotide binding]
634455006327	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634455006328	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634455006329	RNA binding surface [nucleotide binding]; other site
634455006330	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634455006331	active site
634455006332	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
634455006333	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
634455006334	ABC-ATPase subunit  interface; other site
634455006335	dimer interface [polypeptide binding]; other site
634455006336	putative PBP binding regions; other site
634455006337	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
634455006338	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
634455006339	Walker A/P-loop; other site
634455006340	ATP binding site [chemical binding]; other site
634455006341	Q-loop/lid; other site
634455006342	ABC transporter signature motif; other site
634455006343	Walker B; other site
634455006344	D-loop; other site
634455006345	H-loop/switch region; other site
634455006346	Uncharacterized conserved protein [Function unknown]; Region: COG0397
634455006347	hypothetical protein; Validated; Region: PRK00029
634455006348	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
634455006349	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
634455006350	homodimer interface [polypeptide binding]; other site
634455006351	substrate-cofactor binding pocket; other site
634455006352	catalytic residue [active]
634455006353	DNA polymerase I; Provisional; Region: PRK05755
634455006354	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
634455006355	active site
634455006356	metal binding site 1 [ion binding]; metal-binding site
634455006357	putative 5' ssDNA interaction site; other site
634455006358	metal binding site 3; metal-binding site
634455006359	metal binding site 2 [ion binding]; metal-binding site
634455006360	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
634455006361	putative DNA binding site [nucleotide binding]; other site
634455006362	putative metal binding site [ion binding]; other site
634455006363	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
634455006364	active site
634455006365	catalytic site [active]
634455006366	substrate binding site [chemical binding]; other site
634455006367	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
634455006368	active site
634455006369	DNA binding site [nucleotide binding]
634455006370	catalytic site [active]
634455006371	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
634455006372	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
634455006373	Cu(I) binding site [ion binding]; other site
634455006374	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
634455006375	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634455006376	putative acyl-acceptor binding pocket; other site
634455006377	proline/glycine betaine transporter; Provisional; Region: PRK10642
634455006378	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455006379	putative substrate translocation pore; other site
634455006380	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455006381	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455006382	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
634455006383	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
634455006384	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
634455006385	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
634455006386	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
634455006387	L-asparagine permease; Provisional; Region: PRK15049
634455006388	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634455006389	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634455006390	Trp docking motif [polypeptide binding]; other site
634455006391	putative active site [active]
634455006392	Hint domain; Region: Hint_2; pfam13403
634455006393	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
634455006394	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
634455006395	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634455006396	inhibitor-cofactor binding pocket; inhibition site
634455006397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455006398	catalytic residue [active]
634455006399	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
634455006400	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634455006401	DNA-binding site [nucleotide binding]; DNA binding site
634455006402	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455006403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455006404	homodimer interface [polypeptide binding]; other site
634455006405	catalytic residue [active]
634455006406	allantoate amidohydrolase; Reviewed; Region: PRK09290
634455006407	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
634455006408	active site
634455006409	metal binding site [ion binding]; metal-binding site
634455006410	dimer interface [polypeptide binding]; other site
634455006411	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
634455006412	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
634455006413	homodimer interface [polypeptide binding]; other site
634455006414	active site
634455006415	FMN binding site [chemical binding]; other site
634455006416	substrate binding site [chemical binding]; other site
634455006417	4Fe-4S binding domain; Region: Fer4; pfam00037
634455006418	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
634455006419	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
634455006420	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634455006421	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634455006422	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455006423	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634455006424	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634455006425	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634455006426	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634455006427	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634455006428	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634455006429	Transposase; Region: HTH_Tnp_1; pfam01527
634455006430	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455006431	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634455006432	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
634455006433	phenylhydantoinase; Validated; Region: PRK08323
634455006434	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
634455006435	tetramer interface [polypeptide binding]; other site
634455006436	active site
634455006437	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634455006438	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
634455006439	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
634455006440	putative substrate binding site [chemical binding]; other site
634455006441	Na binding site [ion binding]; other site
634455006442	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455006443	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
634455006444	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
634455006445	active site
634455006446	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
634455006447	active site
634455006448	dimer interface [polypeptide binding]; other site
634455006449	Preprotein translocase subunit SecB; Region: SecB; pfam02556
634455006450	SecA binding site; other site
634455006451	Preprotein binding site; other site
634455006452	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
634455006453	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
634455006454	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
634455006455	active site
634455006456	hydrophilic channel; other site
634455006457	catalytic residues [active]
634455006458	active site lid [active]
634455006459	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
634455006460	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
634455006461	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
634455006462	Na binding site [ion binding]; other site
634455006463	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
634455006464	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
634455006465	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
634455006466	Beta-lactamase; Region: Beta-lactamase; pfam00144
634455006467	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634455006468	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455006469	non-specific DNA binding site [nucleotide binding]; other site
634455006470	salt bridge; other site
634455006471	sequence-specific DNA binding site [nucleotide binding]; other site
634455006472	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
634455006473	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
634455006474	heme-binding site [chemical binding]; other site
634455006475	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
634455006476	FAD binding pocket [chemical binding]; other site
634455006477	FAD binding motif [chemical binding]; other site
634455006478	phosphate binding motif [ion binding]; other site
634455006479	beta-alpha-beta structure motif; other site
634455006480	NAD binding pocket [chemical binding]; other site
634455006481	Heme binding  pocket [chemical binding]; other site
634455006482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455006483	dimer interface [polypeptide binding]; other site
634455006484	conserved gate region; other site
634455006485	putative PBP binding loops; other site
634455006486	ABC-ATPase subunit interface; other site
634455006487	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
634455006488	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
634455006489	Walker A/P-loop; other site
634455006490	ATP binding site [chemical binding]; other site
634455006491	Q-loop/lid; other site
634455006492	ABC transporter signature motif; other site
634455006493	Walker B; other site
634455006494	D-loop; other site
634455006495	H-loop/switch region; other site
634455006496	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
634455006497	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
634455006498	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
634455006499	FAD binding domain; Region: FAD_binding_4; pfam01565
634455006500	siroheme synthase; Provisional; Region: cysG; PRK10637
634455006501	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
634455006502	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
634455006503	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
634455006504	active site
634455006505	SAM binding site [chemical binding]; other site
634455006506	homodimer interface [polypeptide binding]; other site
634455006507	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634455006508	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634455006509	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634455006510	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
634455006511	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
634455006512	Amidase; Region: Amidase; cl11426
634455006513	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
634455006514	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
634455006515	intersubunit interface [polypeptide binding]; other site
634455006516	active site
634455006517	Zn2+ binding site [ion binding]; other site
634455006518	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
634455006519	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
634455006520	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
634455006521	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
634455006522	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
634455006523	FMN-binding pocket [chemical binding]; other site
634455006524	flavin binding motif; other site
634455006525	phosphate binding motif [ion binding]; other site
634455006526	beta-alpha-beta structure motif; other site
634455006527	NAD binding pocket [chemical binding]; other site
634455006528	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634455006529	catalytic loop [active]
634455006530	iron binding site [ion binding]; other site
634455006531	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
634455006532	classical (c) SDRs; Region: SDR_c; cd05233
634455006533	NAD(P) binding site [chemical binding]; other site
634455006534	active site
634455006535	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
634455006536	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634455006537	[2Fe-2S] cluster binding site [ion binding]; other site
634455006538	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
634455006539	putative alpha subunit interface [polypeptide binding]; other site
634455006540	putative active site [active]
634455006541	putative substrate binding site [chemical binding]; other site
634455006542	Fe binding site [ion binding]; other site
634455006543	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634455006544	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634455006545	active site
634455006546	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
634455006547	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
634455006548	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634455006549	NAD(P) binding site [chemical binding]; other site
634455006550	catalytic residues [active]
634455006551	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
634455006552	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
634455006553	Trp docking motif [polypeptide binding]; other site
634455006554	cytochrome domain interface [polypeptide binding]; other site
634455006555	active site
634455006556	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634455006557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455006558	putative substrate translocation pore; other site
634455006559	SnoaL-like domain; Region: SnoaL_4; pfam13577
634455006560	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455006561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455006562	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
634455006563	putative substrate binding pocket [chemical binding]; other site
634455006564	dimerization interface [polypeptide binding]; other site
634455006565	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
634455006566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455006567	dimer interface [polypeptide binding]; other site
634455006568	conserved gate region; other site
634455006569	putative PBP binding loops; other site
634455006570	ABC-ATPase subunit interface; other site
634455006571	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455006572	ABC-ATPase subunit interface; other site
634455006573	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455006574	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455006575	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455006576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
634455006577	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
634455006578	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
634455006579	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
634455006580	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455006581	Walker A/P-loop; other site
634455006582	ATP binding site [chemical binding]; other site
634455006583	Q-loop/lid; other site
634455006584	ABC transporter signature motif; other site
634455006585	Walker B; other site
634455006586	D-loop; other site
634455006587	H-loop/switch region; other site
634455006588	TOBE domain; Region: TOBE_2; pfam08402
634455006589	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
634455006590	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
634455006591	tetrameric interface [polypeptide binding]; other site
634455006592	NAD binding site [chemical binding]; other site
634455006593	catalytic residues [active]
634455006594	substrate binding site [chemical binding]; other site
634455006595	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
634455006596	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
634455006597	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634455006598	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
634455006599	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634455006600	Sel1-like repeats; Region: SEL1; smart00671
634455006601	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634455006602	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634455006603	N-terminal plug; other site
634455006604	ligand-binding site [chemical binding]; other site
634455006605	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
634455006606	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634455006607	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
634455006608	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634455006609	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634455006610	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455006611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455006612	LysR substrate binding domain; Region: LysR_substrate; pfam03466
634455006613	dimerization interface [polypeptide binding]; other site
634455006614	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634455006615	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634455006616	[2Fe-2S] cluster binding site [ion binding]; other site
634455006617	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
634455006618	hydrophobic ligand binding site; other site
634455006619	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
634455006620	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
634455006621	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634455006622	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
634455006623	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
634455006624	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
634455006625	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634455006626	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634455006627	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634455006628	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634455006629	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
634455006630	tetramerization interface [polypeptide binding]; other site
634455006631	NAD(P) binding site [chemical binding]; other site
634455006632	catalytic residues [active]
634455006633	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634455006634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455006635	putative substrate translocation pore; other site
634455006636	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
634455006637	homotrimer interface [polypeptide binding]; other site
634455006638	Walker A motif; other site
634455006639	GTP binding site [chemical binding]; other site
634455006640	Walker B motif; other site
634455006641	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
634455006642	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
634455006643	putative dimer interface [polypeptide binding]; other site
634455006644	active site pocket [active]
634455006645	putative cataytic base [active]
634455006646	cobalamin synthase; Reviewed; Region: cobS; PRK00235
634455006647	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
634455006648	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455006649	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455006650	homodimer interface [polypeptide binding]; other site
634455006651	catalytic residue [active]
634455006652	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
634455006653	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
634455006654	putative FMN binding site [chemical binding]; other site
634455006655	cobyric acid synthase; Provisional; Region: PRK00784
634455006656	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
634455006657	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
634455006658	catalytic triad [active]
634455006659	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
634455006660	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
634455006661	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
634455006662	homodimer interface [polypeptide binding]; other site
634455006663	Walker A motif; other site
634455006664	ATP binding site [chemical binding]; other site
634455006665	hydroxycobalamin binding site [chemical binding]; other site
634455006666	Walker B motif; other site
634455006667	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634455006668	catalytic core [active]
634455006669	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
634455006670	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634455006671	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634455006672	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
634455006673	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
634455006674	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
634455006675	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
634455006676	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
634455006677	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
634455006678	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
634455006679	dimer interface [polypeptide binding]; other site
634455006680	[2Fe-2S] cluster binding site [ion binding]; other site
634455006681	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634455006682	MarR family; Region: MarR; pfam01047
634455006683	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634455006684	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634455006685	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
634455006686	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
634455006687	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
634455006688	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
634455006689	substrate binding site [chemical binding]; other site
634455006690	oxyanion hole (OAH) forming residues; other site
634455006691	trimer interface [polypeptide binding]; other site
634455006692	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
634455006693	Flavin Reductases; Region: FlaRed; cl00801
634455006694	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
634455006695	dimer interface [polypeptide binding]; other site
634455006696	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
634455006697	putative PBP binding regions; other site
634455006698	ABC-ATPase subunit  interface; other site
634455006699	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
634455006700	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455006701	Walker A/P-loop; other site
634455006702	ATP binding site [chemical binding]; other site
634455006703	Q-loop/lid; other site
634455006704	ABC transporter signature motif; other site
634455006705	Walker B; other site
634455006706	D-loop; other site
634455006707	H-loop/switch region; other site
634455006708	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634455006709	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
634455006710	intersubunit interface [polypeptide binding]; other site
634455006711	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
634455006712	metal binding site 2 [ion binding]; metal-binding site
634455006713	putative DNA binding helix; other site
634455006714	metal binding site 1 [ion binding]; metal-binding site
634455006715	dimer interface [polypeptide binding]; other site
634455006716	structural Zn2+ binding site [ion binding]; other site
634455006717	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
634455006718	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
634455006719	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
634455006720	putative deacylase active site [active]
634455006721	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030
634455006722	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
634455006723	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
634455006724	dimer interface [polypeptide binding]; other site
634455006725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455006726	catalytic residue [active]
634455006727	GMP synthase; Reviewed; Region: guaA; PRK00074
634455006728	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
634455006729	AMP/PPi binding site [chemical binding]; other site
634455006730	candidate oxyanion hole; other site
634455006731	catalytic triad [active]
634455006732	potential glutamine specificity residues [chemical binding]; other site
634455006733	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
634455006734	ATP Binding subdomain [chemical binding]; other site
634455006735	Ligand Binding sites [chemical binding]; other site
634455006736	Dimerization subdomain; other site
634455006737	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634455006738	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455006739	catalytic residues [active]
634455006740	catalytic nucleophile [active]
634455006741	Presynaptic Site I dimer interface [polypeptide binding]; other site
634455006742	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634455006743	Synaptic Flat tetramer interface [polypeptide binding]; other site
634455006744	Synaptic Site I dimer interface [polypeptide binding]; other site
634455006745	DNA binding site [nucleotide binding]
634455006746	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455006747	DNA-binding interface [nucleotide binding]; DNA binding site
634455006748	Domain of unknown function (DUF927); Region: DUF927; pfam06048
634455006749	Toprim domain; Region: Toprim_3; pfam13362
634455006750	Helix-turn-helix domain; Region: HTH_17; pfam12728
634455006751	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455006752	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455006753	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455006754	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455006755	salt bridge; other site
634455006756	non-specific DNA binding site [nucleotide binding]; other site
634455006757	sequence-specific DNA binding site [nucleotide binding]; other site
634455006758	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455006759	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455006760	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
634455006761	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
634455006762	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
634455006763	DNA binding residues [nucleotide binding]
634455006764	HNH endonuclease; Region: HNH_2; pfam13391
634455006765	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455006766	active site
634455006767	DNA binding site [nucleotide binding]
634455006768	Int/Topo IB signature motif; other site
634455006769	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634455006770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455006771	putative substrate translocation pore; other site
634455006772	Phage shock protein B; Region: PspB; cl05946
634455006773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455006774	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634455006775	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634455006776	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634455006777	catalytic residue [active]
634455006778	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
634455006779	L-lactate permease; Region: Lactate_perm; cl00701
634455006780	Uncharacterized conserved protein [Function unknown]; Region: COG1359
634455006781	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
634455006782	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
634455006783	NADP binding site [chemical binding]; other site
634455006784	homopentamer interface [polypeptide binding]; other site
634455006785	substrate binding site [chemical binding]; other site
634455006786	active site
634455006787	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
634455006788	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
634455006789	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
634455006790	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
634455006791	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634455006792	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634455006793	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634455006794	catalytic residue [active]
634455006795	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
634455006796	Sporulation related domain; Region: SPOR; pfam05036
634455006797	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
634455006798	ABC-2 type transporter; Region: ABC2_membrane; cl17235
634455006799	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
634455006800	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
634455006801	Walker A/P-loop; other site
634455006802	ATP binding site [chemical binding]; other site
634455006803	Q-loop/lid; other site
634455006804	ABC transporter signature motif; other site
634455006805	Walker B; other site
634455006806	D-loop; other site
634455006807	H-loop/switch region; other site
634455006808	Uncharacterized conserved protein [Function unknown]; Region: COG1742
634455006809	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
634455006810	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
634455006811	Cl binding site [ion binding]; other site
634455006812	oligomer interface [polypeptide binding]; other site
634455006813	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
634455006814	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634455006815	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455006816	homodimer interface [polypeptide binding]; other site
634455006817	catalytic residue [active]
634455006818	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634455006819	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
634455006820	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634455006821	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
634455006822	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
634455006823	TPP-binding site [chemical binding]; other site
634455006824	dimer interface [polypeptide binding]; other site
634455006825	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634455006826	PYR/PP interface [polypeptide binding]; other site
634455006827	dimer interface [polypeptide binding]; other site
634455006828	TPP binding site [chemical binding]; other site
634455006829	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634455006830	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
634455006831	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
634455006832	putative active site [active]
634455006833	catalytic residue [active]
634455006834	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
634455006835	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
634455006836	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
634455006837	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
634455006838	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455006839	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
634455006840	active site
634455006841	motif I; other site
634455006842	motif II; other site
634455006843	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
634455006844	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
634455006845	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
634455006846	putative active site [active]
634455006847	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
634455006848	tetramer (dimer of dimers) interface [polypeptide binding]; other site
634455006849	active site
634455006850	dimer interface [polypeptide binding]; other site
634455006851	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
634455006852	AAA domain; Region: AAA_33; pfam13671
634455006853	ATP-binding site [chemical binding]; other site
634455006854	Gluconate-6-phosphate binding site [chemical binding]; other site
634455006855	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
634455006856	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634455006857	intersubunit interface [polypeptide binding]; other site
634455006858	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
634455006859	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
634455006860	Cl- selectivity filter; other site
634455006861	Cl- binding residues [ion binding]; other site
634455006862	pore gating glutamate residue; other site
634455006863	dimer interface [polypeptide binding]; other site
634455006864	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
634455006865	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
634455006866	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
634455006867	NAD(P) binding site [chemical binding]; other site
634455006868	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
634455006869	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634455006870	catalytic residue [active]
634455006871	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
634455006872	potassium uptake protein; Region: kup; TIGR00794
634455006873	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
634455006874	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455006875	FeS/SAM binding site; other site
634455006876	HemN C-terminal domain; Region: HemN_C; pfam06969
634455006877	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
634455006878	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
634455006879	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
634455006880	Walker A/P-loop; other site
634455006881	ATP binding site [chemical binding]; other site
634455006882	Q-loop/lid; other site
634455006883	ABC transporter signature motif; other site
634455006884	Walker B; other site
634455006885	D-loop; other site
634455006886	H-loop/switch region; other site
634455006887	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
634455006888	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
634455006889	Walker A/P-loop; other site
634455006890	ATP binding site [chemical binding]; other site
634455006891	Q-loop/lid; other site
634455006892	ABC transporter signature motif; other site
634455006893	Walker B; other site
634455006894	D-loop; other site
634455006895	H-loop/switch region; other site
634455006896	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
634455006897	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
634455006898	TM-ABC transporter signature motif; other site
634455006899	HEAT repeats; Region: HEAT_2; pfam13646
634455006900	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
634455006901	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
634455006902	TM-ABC transporter signature motif; other site
634455006903	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
634455006904	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
634455006905	putative ligand binding site [chemical binding]; other site
634455006906	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634455006907	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634455006908	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455006909	dimer interface [polypeptide binding]; other site
634455006910	phosphorylation site [posttranslational modification]
634455006911	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455006912	ATP binding site [chemical binding]; other site
634455006913	Mg2+ binding site [ion binding]; other site
634455006914	G-X-G motif; other site
634455006915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455006916	Response regulator receiver domain; Region: Response_reg; pfam00072
634455006917	active site
634455006918	phosphorylation site [posttranslational modification]
634455006919	intermolecular recognition site; other site
634455006920	dimerization interface [polypeptide binding]; other site
634455006921	Response regulator receiver domain; Region: Response_reg; pfam00072
634455006922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455006923	active site
634455006924	phosphorylation site [posttranslational modification]
634455006925	intermolecular recognition site; other site
634455006926	dimerization interface [polypeptide binding]; other site
634455006927	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
634455006928	DNA binding residues [nucleotide binding]
634455006929	HTH-like domain; Region: HTH_21; pfam13276
634455006930	Integrase core domain; Region: rve; pfam00665
634455006931	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455006932	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634455006933	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
634455006934	UreF; Region: UreF; pfam01730
634455006935	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
634455006936	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
634455006937	dimer interface [polypeptide binding]; other site
634455006938	catalytic residues [active]
634455006939	urease subunit alpha; Reviewed; Region: ureC; PRK13207
634455006940	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
634455006941	subunit interactions [polypeptide binding]; other site
634455006942	active site
634455006943	flap region; other site
634455006944	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
634455006945	alpha-beta subunit interface [polypeptide binding]; other site
634455006946	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
634455006947	alpha-gamma subunit interface [polypeptide binding]; other site
634455006948	beta-gamma subunit interface [polypeptide binding]; other site
634455006949	UreD urease accessory protein; Region: UreD; pfam01774
634455006950	High-affinity nickel-transport protein; Region: NicO; cl00964
634455006951	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
634455006952	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
634455006953	dimer interface [polypeptide binding]; other site
634455006954	PYR/PP interface [polypeptide binding]; other site
634455006955	TPP binding site [chemical binding]; other site
634455006956	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634455006957	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
634455006958	TPP-binding site [chemical binding]; other site
634455006959	dimer interface [polypeptide binding]; other site
634455006960	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
634455006961	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
634455006962	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
634455006963	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
634455006964	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
634455006965	heme binding site [chemical binding]; other site
634455006966	ferroxidase pore; other site
634455006967	ferroxidase diiron center [ion binding]; other site
634455006968	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
634455006969	ArsC family; Region: ArsC; pfam03960
634455006970	putative catalytic residues [active]
634455006971	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
634455006972	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
634455006973	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634455006974	dimerization interface [polypeptide binding]; other site
634455006975	putative DNA binding site [nucleotide binding]; other site
634455006976	putative Zn2+ binding site [ion binding]; other site
634455006977	peroxiredoxin; Provisional; Region: PRK13189
634455006978	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634455006979	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
634455006980	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
634455006981	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
634455006982	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
634455006983	Sulfate transporter family; Region: Sulfate_transp; pfam00916
634455006984	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
634455006985	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634455006986	catalytic residues [active]
634455006987	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455006988	Pirin-related protein [General function prediction only]; Region: COG1741
634455006989	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634455006990	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
634455006991	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455006992	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455006993	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634455006994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455006995	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455006996	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455006997	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
634455006998	putative dimerization interface [polypeptide binding]; other site
634455006999	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455007000	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634455007001	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
634455007002	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455007003	putative substrate translocation pore; other site
634455007004	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455007005	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455007006	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
634455007007	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634455007008	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
634455007009	Isochorismatase family; Region: Isochorismatase; pfam00857
634455007010	catalytic triad [active]
634455007011	conserved cis-peptide bond; other site
634455007012	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
634455007013	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634455007014	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634455007015	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634455007016	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
634455007017	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634455007018	Cytochrome c; Region: Cytochrom_C; pfam00034
634455007019	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634455007020	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634455007021	Cytochrome c; Region: Cytochrom_C; pfam00034
634455007022	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
634455007023	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
634455007024	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634455007025	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634455007026	Transcriptional regulators [Transcription]; Region: MarR; COG1846
634455007027	MarR family; Region: MarR_2; pfam12802
634455007028	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455007029	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
634455007030	active site
634455007031	catalytic triad [active]
634455007032	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455007033	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
634455007034	Walker A motif; other site
634455007035	ATP binding site [chemical binding]; other site
634455007036	Walker B motif; other site
634455007037	arginine finger; other site
634455007038	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
634455007039	putative transposase OrfB; Reviewed; Region: PHA02517
634455007040	HTH-like domain; Region: HTH_21; pfam13276
634455007041	Integrase core domain; Region: rve; pfam00665
634455007042	Integrase core domain; Region: rve_3; pfam13683
634455007043	Transposase; Region: HTH_Tnp_1; cl17663
634455007044	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
634455007045	conjugal transfer protein TrbF; Provisional; Region: PRK13872
634455007046	conjugal transfer protein TrbL; Provisional; Region: PRK13875
634455007047	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
634455007048	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455007049	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634455007050	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
634455007051	catalytic residues [active]
634455007052	catalytic nucleophile [active]
634455007053	Recombinase; Region: Recombinase; pfam07508
634455007054	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455007055	non-specific DNA binding site [nucleotide binding]; other site
634455007056	salt bridge; other site
634455007057	sequence-specific DNA binding site [nucleotide binding]; other site
634455007058	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
634455007059	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455007060	putative transposase OrfB; Reviewed; Region: PHA02517
634455007061	HTH-like domain; Region: HTH_21; pfam13276
634455007062	Integrase core domain; Region: rve; pfam00665
634455007063	Integrase core domain; Region: rve_3; pfam13683
634455007064	Transposase; Region: HTH_Tnp_1; cl17663
634455007065	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
634455007066	Replication initiator protein A; Region: RPA; pfam10134
634455007067	putative transposase OrfB; Reviewed; Region: PHA02517
634455007068	HTH-like domain; Region: HTH_21; pfam13276
634455007069	Integrase core domain; Region: rve; pfam00665
634455007070	Integrase core domain; Region: rve_3; pfam13683
634455007071	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455007072	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455007073	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
634455007074	NAD(P) binding site [chemical binding]; other site
634455007075	active site
634455007076	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
634455007077	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
634455007078	Protein required for attachment to host cells; Region: Host_attach; pfam10116
634455007079	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
634455007080	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
634455007081	XdhC Rossmann domain; Region: XdhC_C; pfam13478
634455007082	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
634455007083	Ligand binding site; other site
634455007084	metal-binding site
634455007085	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
634455007086	homotrimer interaction site [polypeptide binding]; other site
634455007087	putative active site [active]
634455007088	CHAP domain; Region: CHAP; cl17642
634455007089	glycine dehydrogenase; Provisional; Region: PRK05367
634455007090	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
634455007091	tetramer interface [polypeptide binding]; other site
634455007092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455007093	catalytic residue [active]
634455007094	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
634455007095	tetramer interface [polypeptide binding]; other site
634455007096	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455007097	catalytic residue [active]
634455007098	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
634455007099	lipoyl attachment site [posttranslational modification]; other site
634455007100	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
634455007101	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
634455007102	spermidine synthase; Provisional; Region: PRK00811
634455007103	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455007104	S-adenosylmethionine binding site [chemical binding]; other site
634455007105	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
634455007106	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455007107	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455007108	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634455007109	putative effector binding pocket; other site
634455007110	dimerization interface [polypeptide binding]; other site
634455007111	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
634455007112	active site
634455007113	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
634455007114	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
634455007115	active site
634455007116	(T/H)XGH motif; other site
634455007117	DNA gyrase, A subunit; Region: gyrA; TIGR01063
634455007118	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
634455007119	CAP-like domain; other site
634455007120	active site
634455007121	primary dimer interface [polypeptide binding]; other site
634455007122	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634455007123	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634455007124	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634455007125	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634455007126	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634455007127	FMN binding site [chemical binding]; other site
634455007128	substrate binding site [chemical binding]; other site
634455007129	putative catalytic residue [active]
634455007130	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
634455007131	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
634455007132	RNase E interface [polypeptide binding]; other site
634455007133	trimer interface [polypeptide binding]; other site
634455007134	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
634455007135	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
634455007136	RNase E interface [polypeptide binding]; other site
634455007137	trimer interface [polypeptide binding]; other site
634455007138	active site
634455007139	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
634455007140	putative nucleic acid binding region [nucleotide binding]; other site
634455007141	G-X-X-G motif; other site
634455007142	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
634455007143	RNA binding site [nucleotide binding]; other site
634455007144	domain interface; other site
634455007145	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
634455007146	16S/18S rRNA binding site [nucleotide binding]; other site
634455007147	S13e-L30e interaction site [polypeptide binding]; other site
634455007148	25S rRNA binding site [nucleotide binding]; other site
634455007149	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
634455007150	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
634455007151	RNA binding site [nucleotide binding]; other site
634455007152	active site
634455007153	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
634455007154	Permease; Region: Permease; pfam02405
634455007155	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
634455007156	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
634455007157	Walker A/P-loop; other site
634455007158	ATP binding site [chemical binding]; other site
634455007159	Q-loop/lid; other site
634455007160	ABC transporter signature motif; other site
634455007161	Walker B; other site
634455007162	D-loop; other site
634455007163	H-loop/switch region; other site
634455007164	mce related protein; Region: MCE; pfam02470
634455007165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
634455007166	Protein of unknown function (DUF330); Region: DUF330; pfam03886
634455007167	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455007168	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
634455007169	putative ADP-binding pocket [chemical binding]; other site
634455007170	Clostridial hydrophobic W; Region: ChW; cl02763
634455007171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
634455007172	binding surface
634455007173	TPR motif; other site
634455007174	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634455007175	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634455007176	active site
634455007177	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634455007178	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455007179	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634455007180	Sel1-like repeats; Region: SEL1; smart00671
634455007181	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634455007182	Sel1-like repeats; Region: SEL1; smart00671
634455007183	Sel1-like repeats; Region: SEL1; smart00671
634455007184	Sel1 repeat; Region: Sel1; cl02723
634455007185	Sel1-like repeats; Region: SEL1; smart00671
634455007186	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
634455007187	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455007188	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455007189	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
634455007190	putative active site [active]
634455007191	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
634455007192	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634455007193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455007194	Walker A/P-loop; other site
634455007195	ATP binding site [chemical binding]; other site
634455007196	Q-loop/lid; other site
634455007197	ABC transporter signature motif; other site
634455007198	Walker B; other site
634455007199	D-loop; other site
634455007200	H-loop/switch region; other site
634455007201	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
634455007202	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
634455007203	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
634455007204	substrate binding pocket [chemical binding]; other site
634455007205	dimer interface [polypeptide binding]; other site
634455007206	inhibitor binding site; inhibition site
634455007207	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
634455007208	B12 binding site [chemical binding]; other site
634455007209	cobalt ligand [ion binding]; other site
634455007210	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
634455007211	Colicin V production protein; Region: Colicin_V; pfam02674
634455007212	amidophosphoribosyltransferase; Provisional; Region: PRK09123
634455007213	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
634455007214	active site
634455007215	tetramer interface [polypeptide binding]; other site
634455007216	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634455007217	active site
634455007218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
634455007219	Protein of unknown function (DUF330); Region: DUF330; pfam03886
634455007220	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
634455007221	mce related protein; Region: MCE; pfam02470
634455007222	mce related protein; Region: MCE; pfam02470
634455007223	mce related protein; Region: MCE; pfam02470
634455007224	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
634455007225	Paraquat-inducible protein A; Region: PqiA; pfam04403
634455007226	Paraquat-inducible protein A; Region: PqiA; pfam04403
634455007227	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
634455007228	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
634455007229	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
634455007230	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634455007231	active site
634455007232	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
634455007233	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
634455007234	ATP synthase subunit C; Region: ATP-synt_C; cl00466
634455007235	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
634455007236	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
634455007237	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
634455007238	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
634455007239	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
634455007240	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634455007241	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
634455007242	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
634455007243	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455007244	FeS/SAM binding site; other site
634455007245	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
634455007246	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
634455007247	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
634455007248	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634455007249	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
634455007250	dimer interface [polypeptide binding]; other site
634455007251	active site
634455007252	metal binding site [ion binding]; metal-binding site
634455007253	glutathione binding site [chemical binding]; other site
634455007254	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634455007255	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634455007256	ATP binding site [chemical binding]; other site
634455007257	Mg++ binding site [ion binding]; other site
634455007258	motif III; other site
634455007259	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634455007260	nucleotide binding region [chemical binding]; other site
634455007261	ATP-binding site [chemical binding]; other site
634455007262	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
634455007263	RNA binding site [nucleotide binding]; other site
634455007264	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
634455007265	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
634455007266	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
634455007267	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
634455007268	23S rRNA interface [nucleotide binding]; other site
634455007269	L3 interface [polypeptide binding]; other site
634455007270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455007271	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
634455007272	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455007273	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
634455007274	PhoU domain; Region: PhoU; pfam01895
634455007275	PhoU domain; Region: PhoU; pfam01895
634455007276	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
634455007277	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
634455007278	Walker A/P-loop; other site
634455007279	ATP binding site [chemical binding]; other site
634455007280	Q-loop/lid; other site
634455007281	ABC transporter signature motif; other site
634455007282	Walker B; other site
634455007283	D-loop; other site
634455007284	H-loop/switch region; other site
634455007285	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
634455007286	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455007287	dimer interface [polypeptide binding]; other site
634455007288	conserved gate region; other site
634455007289	putative PBP binding loops; other site
634455007290	ABC-ATPase subunit interface; other site
634455007291	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
634455007292	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455007293	dimer interface [polypeptide binding]; other site
634455007294	conserved gate region; other site
634455007295	putative PBP binding loops; other site
634455007296	ABC-ATPase subunit interface; other site
634455007297	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
634455007298	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
634455007299	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
634455007300	NADP binding site [chemical binding]; other site
634455007301	dimer interface [polypeptide binding]; other site
634455007302	Predicted membrane protein [Function unknown]; Region: COG1289
634455007303	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
634455007304	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
634455007305	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634455007306	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634455007307	protein binding site [polypeptide binding]; other site
634455007308	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634455007309	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
634455007310	active site
634455007311	catalytic triad [active]
634455007312	oxyanion hole [active]
634455007313	OpgC protein; Region: OpgC_C; pfam10129
634455007314	Acyltransferase family; Region: Acyl_transf_3; pfam01757
634455007315	antiporter inner membrane protein; Provisional; Region: PRK11670
634455007316	Domain of unknown function DUF59; Region: DUF59; pfam01883
634455007317	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
634455007318	Walker A motif; other site
634455007319	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
634455007320	Stringent starvation protein B; Region: SspB; cl01120
634455007321	fumarate hydratase; Provisional; Region: PRK15389
634455007322	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
634455007323	Fumarase C-terminus; Region: Fumerase_C; pfam05683
634455007324	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
634455007325	dimer interface [polypeptide binding]; other site
634455007326	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634455007327	metal binding site [ion binding]; metal-binding site
634455007328	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
634455007329	AntA/AntB antirepressor; Region: AntA; cl01430
634455007330	Putative glucoamylase; Region: Glycoamylase; pfam10091
634455007331	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
634455007332	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634455007333	hydroxyglutarate oxidase; Provisional; Region: PRK11728
634455007334	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
634455007335	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
634455007336	active site
634455007337	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634455007338	dimer interface [polypeptide binding]; other site
634455007339	substrate binding site [chemical binding]; other site
634455007340	catalytic residues [active]
634455007341	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634455007342	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634455007343	putative DNA binding site [nucleotide binding]; other site
634455007344	putative Zn2+ binding site [ion binding]; other site
634455007345	AsnC family; Region: AsnC_trans_reg; pfam01037
634455007346	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
634455007347	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
634455007348	translation initiation factor IF-2; Region: IF-2; TIGR00487
634455007349	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
634455007350	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
634455007351	G1 box; other site
634455007352	putative GEF interaction site [polypeptide binding]; other site
634455007353	GTP/Mg2+ binding site [chemical binding]; other site
634455007354	Switch I region; other site
634455007355	G2 box; other site
634455007356	G3 box; other site
634455007357	Switch II region; other site
634455007358	G4 box; other site
634455007359	G5 box; other site
634455007360	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
634455007361	Translation-initiation factor 2; Region: IF-2; pfam11987
634455007362	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
634455007363	hypothetical protein; Provisional; Region: PRK09190
634455007364	Protein of unknown function (DUF448); Region: DUF448; pfam04296
634455007365	putative RNA binding cleft [nucleotide binding]; other site
634455007366	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
634455007367	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
634455007368	NusA N-terminal domain; Region: NusA_N; pfam08529
634455007369	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
634455007370	RNA binding site [nucleotide binding]; other site
634455007371	homodimer interface [polypeptide binding]; other site
634455007372	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
634455007373	G-X-X-G motif; other site
634455007374	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
634455007375	G-X-X-G motif; other site
634455007376	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
634455007377	hypothetical protein; Provisional; Region: PRK14636
634455007378	Sm and related proteins; Region: Sm_like; cl00259
634455007379	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
634455007380	putative RNA binding site [nucleotide binding]; other site
634455007381	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
634455007382	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455007383	Walker A motif; other site
634455007384	ATP binding site [chemical binding]; other site
634455007385	Walker B motif; other site
634455007386	arginine finger; other site
634455007387	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455007388	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455007389	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634455007390	putative effector binding pocket; other site
634455007391	dimerization interface [polypeptide binding]; other site
634455007392	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
634455007393	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
634455007394	substrate binding pocket [chemical binding]; other site
634455007395	membrane-bound complex binding site; other site
634455007396	hinge residues; other site
634455007397	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
634455007398	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634455007399	dimer interface [polypeptide binding]; other site
634455007400	conserved gate region; other site
634455007401	putative PBP binding loops; other site
634455007402	ABC-ATPase subunit interface; other site
634455007403	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
634455007404	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455007405	Walker A/P-loop; other site
634455007406	ATP binding site [chemical binding]; other site
634455007407	Q-loop/lid; other site
634455007408	ABC transporter signature motif; other site
634455007409	Walker B; other site
634455007410	D-loop; other site
634455007411	H-loop/switch region; other site
634455007412	aconitate hydratase; Validated; Region: PRK09277
634455007413	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
634455007414	substrate binding site [chemical binding]; other site
634455007415	ligand binding site [chemical binding]; other site
634455007416	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
634455007417	substrate binding site [chemical binding]; other site
634455007418	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
634455007419	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455007420	Walker A/P-loop; other site
634455007421	ATP binding site [chemical binding]; other site
634455007422	Q-loop/lid; other site
634455007423	ABC transporter signature motif; other site
634455007424	Walker B; other site
634455007425	D-loop; other site
634455007426	H-loop/switch region; other site
634455007427	CcmB protein; Region: CcmB; pfam03379
634455007428	hypothetical protein; Provisional; Region: PRK10316
634455007429	YfdX protein; Region: YfdX; pfam10938
634455007430	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
634455007431	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
634455007432	dimer interface [polypeptide binding]; other site
634455007433	active site
634455007434	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634455007435	catalytic residues [active]
634455007436	substrate binding site [chemical binding]; other site
634455007437	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
634455007438	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
634455007439	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
634455007440	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
634455007441	Dehydroquinase class II; Region: DHquinase_II; pfam01220
634455007442	trimer interface [polypeptide binding]; other site
634455007443	active site
634455007444	dimer interface [polypeptide binding]; other site
634455007445	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634455007446	carboxyltransferase (CT) interaction site; other site
634455007447	biotinylation site [posttranslational modification]; other site
634455007448	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
634455007449	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634455007450	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634455007451	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
634455007452	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634455007453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455007454	putative substrate translocation pore; other site
634455007455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455007456	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
634455007457	ThiC-associated domain; Region: ThiC-associated; pfam13667
634455007458	ThiC family; Region: ThiC; pfam01964
634455007459	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
634455007460	Iron permease FTR1 family; Region: FTR1; cl00475
634455007461	Fe2+ transport protein; Region: Iron_transport; cl01377
634455007462	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634455007463	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
634455007464	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
634455007465	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634455007466	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
634455007467	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455007468	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634455007469	dimerization interface [polypeptide binding]; other site
634455007470	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
634455007471	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634455007472	inhibitor-cofactor binding pocket; inhibition site
634455007473	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634455007474	catalytic residue [active]
634455007475	Synuclein; Region: Synuclein; pfam01387
634455007476	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
634455007477	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
634455007478	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
634455007479	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
634455007480	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
634455007481	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
634455007482	GatB domain; Region: GatB_Yqey; smart00845
634455007483	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634455007484	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634455007485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634455007486	Walker A/P-loop; other site
634455007487	ATP binding site [chemical binding]; other site
634455007488	Q-loop/lid; other site
634455007489	ABC transporter signature motif; other site
634455007490	Walker B; other site
634455007491	D-loop; other site
634455007492	H-loop/switch region; other site
634455007493	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
634455007494	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
634455007495	minor groove reading motif; other site
634455007496	helix-hairpin-helix signature motif; other site
634455007497	substrate binding pocket [chemical binding]; other site
634455007498	active site
634455007499	ferrochelatase; Reviewed; Region: hemH; PRK00035
634455007500	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
634455007501	C-terminal domain interface [polypeptide binding]; other site
634455007502	active site
634455007503	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
634455007504	active site
634455007505	N-terminal domain interface [polypeptide binding]; other site
634455007506	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
634455007507	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
634455007508	minor groove reading motif; other site
634455007509	helix-hairpin-helix signature motif; other site
634455007510	substrate binding pocket [chemical binding]; other site
634455007511	active site
634455007512	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
634455007513	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
634455007514	DNA binding and oxoG recognition site [nucleotide binding]
634455007515	Protein of unknown function (DUF721); Region: DUF721; cl02324
634455007516	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634455007517	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634455007518	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634455007519	catalytic residue [active]
634455007520	Sporulation related domain; Region: SPOR; cl10051
634455007521	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
634455007522	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
634455007523	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
634455007524	HIGH motif; other site
634455007525	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
634455007526	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634455007527	active site
634455007528	KMSKS motif; other site
634455007529	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
634455007530	tRNA binding surface [nucleotide binding]; other site
634455007531	Lipopolysaccharide-assembly; Region: LptE; pfam04390
634455007532	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
634455007533	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
634455007534	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634455007535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455007536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455007537	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
634455007538	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
634455007539	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
634455007540	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
634455007541	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
634455007542	Ligand binding site [chemical binding]; other site
634455007543	Electron transfer flavoprotein domain; Region: ETF; pfam01012
634455007544	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
634455007545	hydroxyglutarate oxidase; Provisional; Region: PRK11728
634455007546	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
634455007547	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
634455007548	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
634455007549	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634455007550	FeS/SAM binding site; other site
634455007551	HemN C-terminal domain; Region: HemN_C; pfam06969
634455007552	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
634455007553	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
634455007554	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
634455007555	ligand binding site [chemical binding]; other site
634455007556	flexible hinge region; other site
634455007557	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
634455007558	putative switch regulator; other site
634455007559	non-specific DNA interactions [nucleotide binding]; other site
634455007560	DNA binding site [nucleotide binding]
634455007561	sequence specific DNA binding site [nucleotide binding]; other site
634455007562	putative cAMP binding site [chemical binding]; other site
634455007563	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
634455007564	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634455007565	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634455007566	protein binding site [polypeptide binding]; other site
634455007567	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634455007568	protein binding site [polypeptide binding]; other site
634455007569	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
634455007570	nucleoside/Zn binding site; other site
634455007571	dimer interface [polypeptide binding]; other site
634455007572	catalytic motif [active]
634455007573	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
634455007574	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
634455007575	catalytic triad [active]
634455007576	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
634455007577	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634455007578	RNA binding surface [nucleotide binding]; other site
634455007579	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
634455007580	active site
634455007581	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
634455007582	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455007583	S-adenosylmethionine binding site [chemical binding]; other site
634455007584	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
634455007585	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
634455007586	dimer interface [polypeptide binding]; other site
634455007587	ssDNA binding site [nucleotide binding]; other site
634455007588	tetramer (dimer of dimers) interface [polypeptide binding]; other site
634455007589	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
634455007590	O-Antigen ligase; Region: Wzy_C; pfam04932
634455007591	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
634455007592	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
634455007593	active site
634455007594	catalytic residues [active]
634455007595	DNA binding site [nucleotide binding]
634455007596	Int/Topo IB signature motif; other site
634455007597	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634455007598	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455007599	catalytic residues [active]
634455007600	catalytic nucleophile [active]
634455007601	Presynaptic Site I dimer interface [polypeptide binding]; other site
634455007602	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634455007603	Synaptic Flat tetramer interface [polypeptide binding]; other site
634455007604	Synaptic Site I dimer interface [polypeptide binding]; other site
634455007605	DNA binding site [nucleotide binding]
634455007606	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455007607	DNA-binding interface [nucleotide binding]; DNA binding site
634455007608	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455007609	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634455007610	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455007611	ATP binding site [chemical binding]; other site
634455007612	putative Mg++ binding site [ion binding]; other site
634455007613	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455007614	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455007615	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455007616	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455007617	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
634455007618	putative ADP-binding pocket [chemical binding]; other site
634455007619	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
634455007620	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
634455007621	active site
634455007622	HIGH motif; other site
634455007623	dimer interface [polypeptide binding]; other site
634455007624	KMSKS motif; other site
634455007625	protease TldD; Provisional; Region: tldD; PRK10735
634455007626	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634455007627	catalytic core [active]
634455007628	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
634455007629	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
634455007630	NAD binding site [chemical binding]; other site
634455007631	substrate binding site [chemical binding]; other site
634455007632	homodimer interface [polypeptide binding]; other site
634455007633	active site
634455007634	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
634455007635	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
634455007636	substrate binding site; other site
634455007637	tetramer interface; other site
634455007638	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
634455007639	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
634455007640	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
634455007641	NADP binding site [chemical binding]; other site
634455007642	active site
634455007643	putative substrate binding site [chemical binding]; other site
634455007644	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634455007645	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
634455007646	Probable Catalytic site; other site
634455007647	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
634455007648	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
634455007649	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
634455007650	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
634455007651	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634455007652	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634455007653	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455007654	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
634455007655	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
634455007656	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634455007657	putative C-terminal domain interface [polypeptide binding]; other site
634455007658	putative GSH binding site (G-site) [chemical binding]; other site
634455007659	putative dimer interface [polypeptide binding]; other site
634455007660	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
634455007661	putative N-terminal domain interface [polypeptide binding]; other site
634455007662	putative dimer interface [polypeptide binding]; other site
634455007663	putative substrate binding pocket (H-site) [chemical binding]; other site
634455007664	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
634455007665	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
634455007666	Ligand Binding Site [chemical binding]; other site
634455007667	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
634455007668	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634455007669	catalytic loop [active]
634455007670	iron binding site [ion binding]; other site
634455007671	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
634455007672	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
634455007673	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634455007674	catalytic residue [active]
634455007675	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
634455007676	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634455007677	catalytic residue [active]
634455007678	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
634455007679	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
634455007680	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
634455007681	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
634455007682	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
634455007683	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
634455007684	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
634455007685	active site
634455007686	HIGH motif; other site
634455007687	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
634455007688	KMSKS motif; other site
634455007689	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
634455007690	tRNA binding surface [nucleotide binding]; other site
634455007691	anticodon binding site; other site
634455007692	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
634455007693	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634455007694	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
634455007695	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
634455007696	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
634455007697	catalytic residues [active]
634455007698	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
634455007699	Family description; Region: UvrD_C_2; pfam13538
634455007700	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
634455007701	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
634455007702	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
634455007703	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
634455007704	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634455007705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455007706	active site
634455007707	phosphorylation site [posttranslational modification]
634455007708	intermolecular recognition site; other site
634455007709	dimerization interface [polypeptide binding]; other site
634455007710	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455007711	DNA binding site [nucleotide binding]
634455007712	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
634455007713	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
634455007714	active site
634455007715	substrate binding site [chemical binding]; other site
634455007716	metal binding site [ion binding]; metal-binding site
634455007717	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
634455007718	dihydropteroate synthase; Region: DHPS; TIGR01496
634455007719	substrate binding pocket [chemical binding]; other site
634455007720	dimer interface [polypeptide binding]; other site
634455007721	inhibitor binding site; inhibition site
634455007722	FtsH Extracellular; Region: FtsH_ext; pfam06480
634455007723	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
634455007724	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455007725	Walker A motif; other site
634455007726	ATP binding site [chemical binding]; other site
634455007727	Walker B motif; other site
634455007728	arginine finger; other site
634455007729	Peptidase family M41; Region: Peptidase_M41; pfam01434
634455007730	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
634455007731	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
634455007732	Ligand Binding Site [chemical binding]; other site
634455007733	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
634455007734	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634455007735	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634455007736	ligand binding site [chemical binding]; other site
634455007737	translocation protein TolB; Provisional; Region: tolB; PRK05137
634455007738	TolB amino-terminal domain; Region: TolB_N; pfam04052
634455007739	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
634455007740	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
634455007741	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634455007742	TolR protein; Region: tolR; TIGR02801
634455007743	TolQ protein; Region: tolQ; TIGR02796
634455007744	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
634455007745	active site
634455007746	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
634455007747	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455007748	Walker A motif; other site
634455007749	ATP binding site [chemical binding]; other site
634455007750	Walker B motif; other site
634455007751	arginine finger; other site
634455007752	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
634455007753	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
634455007754	RuvA N terminal domain; Region: RuvA_N; pfam01330
634455007755	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
634455007756	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
634455007757	active site
634455007758	putative DNA-binding cleft [nucleotide binding]; other site
634455007759	dimer interface [polypeptide binding]; other site
634455007760	hypothetical protein; Validated; Region: PRK00110
634455007761	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
634455007762	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
634455007763	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
634455007764	nucleotide binding region [chemical binding]; other site
634455007765	ATP-binding site [chemical binding]; other site
634455007766	SEC-C motif; Region: SEC-C; pfam02810
634455007767	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
634455007768	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
634455007769	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
634455007770	heterotetramer interface [polypeptide binding]; other site
634455007771	active site pocket [active]
634455007772	cleavage site
634455007773	RDD family; Region: RDD; pfam06271
634455007774	putative mechanosensitive channel protein; Provisional; Region: PRK11465
634455007775	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634455007776	Biofilm formation and stress response factor; Region: BsmA; pfam10014
634455007777	chaperone protein DnaJ; Provisional; Region: PRK14299
634455007778	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634455007779	HSP70 interaction site [polypeptide binding]; other site
634455007780	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
634455007781	substrate binding site [polypeptide binding]; other site
634455007782	dimer interface [polypeptide binding]; other site
634455007783	Membrane fusogenic activity; Region: BMFP; pfam04380
634455007784	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
634455007785	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
634455007786	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
634455007787	H+ Antiporter protein; Region: 2A0121; TIGR00900
634455007788	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634455007789	IHF dimer interface [polypeptide binding]; other site
634455007790	IHF - DNA interface [nucleotide binding]; other site
634455007791	Rhamnan synthesis protein F; Region: RgpF; pfam05045
634455007792	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634455007793	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455007794	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455007795	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
634455007796	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634455007797	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
634455007798	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634455007799	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
634455007800	active site
634455007801	NAD synthetase; Reviewed; Region: nadE; PRK02628
634455007802	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
634455007803	multimer interface [polypeptide binding]; other site
634455007804	active site
634455007805	catalytic triad [active]
634455007806	protein interface 1 [polypeptide binding]; other site
634455007807	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
634455007808	homodimer interface [polypeptide binding]; other site
634455007809	NAD binding pocket [chemical binding]; other site
634455007810	ATP binding pocket [chemical binding]; other site
634455007811	Mg binding site [ion binding]; other site
634455007812	active-site loop [active]
634455007813	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
634455007814	putative active site pocket [active]
634455007815	4-fold oligomerization interface [polypeptide binding]; other site
634455007816	metal binding residues [ion binding]; metal-binding site
634455007817	3-fold/trimer interface [polypeptide binding]; other site
634455007818	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
634455007819	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
634455007820	putative active site [active]
634455007821	oxyanion strand; other site
634455007822	catalytic triad [active]
634455007823	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
634455007824	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634455007825	Coenzyme A binding pocket [chemical binding]; other site
634455007826	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
634455007827	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
634455007828	catalytic residues [active]
634455007829	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
634455007830	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
634455007831	substrate binding site [chemical binding]; other site
634455007832	glutamase interaction surface [polypeptide binding]; other site
634455007833	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
634455007834	metal binding site [ion binding]; metal-binding site
634455007835	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
634455007836	nucleotide binding site/active site [active]
634455007837	HIT family signature motif; other site
634455007838	catalytic residue [active]
634455007839	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
634455007840	putative FMN binding site [chemical binding]; other site
634455007841	hypothetical protein; Provisional; Region: PRK09126
634455007842	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634455007843	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
634455007844	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
634455007845	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634455007846	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
634455007847	putative C-terminal domain interface [polypeptide binding]; other site
634455007848	putative GSH binding site (G-site) [chemical binding]; other site
634455007849	putative dimer interface [polypeptide binding]; other site
634455007850	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
634455007851	putative N-terminal domain interface [polypeptide binding]; other site
634455007852	putative dimer interface [polypeptide binding]; other site
634455007853	putative substrate binding pocket (H-site) [chemical binding]; other site
634455007854	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
634455007855	ParB-like nuclease domain; Region: ParB; smart00470
634455007856	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634455007857	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634455007858	P-loop; other site
634455007859	Magnesium ion binding site [ion binding]; other site
634455007860	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634455007861	Magnesium ion binding site [ion binding]; other site
634455007862	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
634455007863	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
634455007864	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
634455007865	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
634455007866	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
634455007867	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
634455007868	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
634455007869	trmE is a tRNA modification GTPase; Region: trmE; cd04164
634455007870	G1 box; other site
634455007871	GTP/Mg2+ binding site [chemical binding]; other site
634455007872	Switch I region; other site
634455007873	G2 box; other site
634455007874	Switch II region; other site
634455007875	G3 box; other site
634455007876	G4 box; other site
634455007877	G5 box; other site
634455007878	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
634455007879	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
634455007880	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
634455007881	DNA binding site [nucleotide binding]
634455007882	active site
634455007883	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455007884	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455007885	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
634455007886	major facilitator superfamily transporter; Provisional; Region: PRK05122
634455007887	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455007888	putative substrate translocation pore; other site
634455007889	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
634455007890	dimer interface [polypeptide binding]; other site
634455007891	ADP-ribose binding site [chemical binding]; other site
634455007892	active site
634455007893	nudix motif; other site
634455007894	metal binding site [ion binding]; metal-binding site
634455007895	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
634455007896	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
634455007897	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634455007898	motif II; other site
634455007899	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
634455007900	substrate binding site [chemical binding]; other site
634455007901	active site
634455007902	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
634455007903	active site
634455007904	dimer interface [polypeptide binding]; other site
634455007905	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
634455007906	Phage Terminase; Region: Terminase_1; pfam03354
634455007907	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634455007908	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455007909	catalytic residues [active]
634455007910	catalytic nucleophile [active]
634455007911	Presynaptic Site I dimer interface [polypeptide binding]; other site
634455007912	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634455007913	Synaptic Flat tetramer interface [polypeptide binding]; other site
634455007914	Synaptic Site I dimer interface [polypeptide binding]; other site
634455007915	DNA binding site [nucleotide binding]
634455007916	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455007917	DNA-binding interface [nucleotide binding]; DNA binding site
634455007918	hypothetical protein; Provisional; Region: PRK14709
634455007919	D5 N terminal like; Region: D5_N; smart00885
634455007920	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
634455007921	polymerase nucleotide-binding site; other site
634455007922	DNA-binding residues [nucleotide binding]; DNA binding site
634455007923	nucleotide binding site [chemical binding]; other site
634455007924	primase nucleotide-binding site [nucleotide binding]; other site
634455007925	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
634455007926	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455007927	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634455007928	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634455007929	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634455007930	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455007931	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455007932	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455007933	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634455007934	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634455007935	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
634455007936	active site
634455007937	NTP binding site [chemical binding]; other site
634455007938	metal binding triad [ion binding]; metal-binding site
634455007939	antibiotic binding site [chemical binding]; other site
634455007940	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
634455007941	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634455007942	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
634455007943	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634455007944	S-adenosylmethionine binding site [chemical binding]; other site
634455007945	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
634455007946	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
634455007947	FMN binding site [chemical binding]; other site
634455007948	active site
634455007949	substrate binding site [chemical binding]; other site
634455007950	catalytic residue [active]
634455007951	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455007952	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634455007953	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455007954	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455007955	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455007956	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
634455007957	putative substrate binding pocket [chemical binding]; other site
634455007958	dimerization interface [polypeptide binding]; other site
634455007959	acetylornithine deacetylase; Provisional; Region: PRK07522
634455007960	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
634455007961	metal binding site [ion binding]; metal-binding site
634455007962	putative dimer interface [polypeptide binding]; other site
634455007963	choline dehydrogenase; Validated; Region: PRK02106
634455007964	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634455007965	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634455007966	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634455007967	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
634455007968	Na binding site [ion binding]; other site
634455007969	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
634455007970	homotrimer interaction site [polypeptide binding]; other site
634455007971	putative active site [active]
634455007972	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634455007973	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
634455007974	NAD(P) binding site [chemical binding]; other site
634455007975	catalytic residues [active]
634455007976	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
634455007977	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
634455007978	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
634455007979	Transposase; Region: HTH_Tnp_1; pfam01527
634455007980	HTH-like domain; Region: HTH_21; pfam13276
634455007981	Integrase core domain; Region: rve; pfam00665
634455007982	Integrase core domain; Region: rve_3; pfam13683
634455007983	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
634455007984	NMT1-like family; Region: NMT1_2; pfam13379
634455007985	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
634455007986	cheY-homologous receiver domain; Region: REC; smart00448
634455007987	ANTAR domain; Region: ANTAR; pfam03861
634455007988	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
634455007989	molybdopterin cofactor binding site; other site
634455007990	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
634455007991	molybdopterin cofactor binding site; other site
634455007992	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
634455007993	Flavodoxin; Region: Flavodoxin_1; pfam00258
634455007994	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
634455007995	FAD binding pocket [chemical binding]; other site
634455007996	conserved FAD binding motif [chemical binding]; other site
634455007997	phosphate binding motif [ion binding]; other site
634455007998	beta-alpha-beta structure motif; other site
634455007999	NAD binding pocket [chemical binding]; other site
634455008000	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455008001	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455008002	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455008003	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
634455008004	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
634455008005	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634455008006	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
634455008007	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
634455008008	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
634455008009	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
634455008010	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
634455008011	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
634455008012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455008013	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
634455008014	sensor protein QseC; Provisional; Region: PRK10337
634455008015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634455008016	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455008017	dimer interface [polypeptide binding]; other site
634455008018	phosphorylation site [posttranslational modification]
634455008019	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634455008020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455008021	active site
634455008022	phosphorylation site [posttranslational modification]
634455008023	intermolecular recognition site; other site
634455008024	dimerization interface [polypeptide binding]; other site
634455008025	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455008026	DNA binding site [nucleotide binding]
634455008027	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634455008028	HlyD family secretion protein; Region: HlyD_2; pfam12700
634455008029	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634455008030	HlyD family secretion protein; Region: HlyD_3; pfam13437
634455008031	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634455008032	Outer membrane efflux protein; Region: OEP; pfam02321
634455008033	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634455008034	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455008035	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
634455008036	methionine synthase; Provisional; Region: PRK01207
634455008037	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
634455008038	substrate binding site [chemical binding]; other site
634455008039	THF binding site; other site
634455008040	zinc-binding site [ion binding]; other site
634455008041	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455008042	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455008043	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
634455008044	putative dimerization interface [polypeptide binding]; other site
634455008045	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455008046	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455008047	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455008048	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634455008049	non-specific DNA binding site [nucleotide binding]; other site
634455008050	salt bridge; other site
634455008051	sequence-specific DNA binding site [nucleotide binding]; other site
634455008052	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
634455008053	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
634455008054	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
634455008055	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
634455008056	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
634455008057	arsenical pump membrane protein; Provisional; Region: PRK15445
634455008058	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
634455008059	transmembrane helices; other site
634455008060	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634455008061	ArsC family; Region: ArsC; pfam03960
634455008062	catalytic residues [active]
634455008063	Protein of unknown function DUF45; Region: DUF45; pfam01863
634455008064	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634455008065	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634455008066	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455008067	ATP binding site [chemical binding]; other site
634455008068	putative Mg++ binding site [ion binding]; other site
634455008069	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634455008070	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634455008071	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634455008072	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
634455008073	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634455008074	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634455008075	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
634455008076	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634455008077	HTH-like domain; Region: HTH_21; pfam13276
634455008078	Integrase core domain; Region: rve; pfam00665
634455008079	Integrase core domain; Region: rve_3; pfam13683
634455008080	Transposase; Region: HTH_Tnp_1; pfam01527
634455008081	CCC1-related family of proteins; Region: CCC1_like; cl00278
634455008082	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634455008083	ArsC family; Region: ArsC; pfam03960
634455008084	catalytic residues [active]
634455008085	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
634455008086	Transposase; Region: HTH_Tnp_1; cl17663
634455008087	putative transposase OrfB; Reviewed; Region: PHA02517
634455008088	HTH-like domain; Region: HTH_21; pfam13276
634455008089	Integrase core domain; Region: rve; pfam00665
634455008090	Integrase core domain; Region: rve_3; pfam13683
634455008091	Integrase core domain; Region: rve; pfam00665
634455008092	Integrase core domain; Region: rve_3; pfam13683
634455008093	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634455008094	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634455008095	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
634455008096	putative substrate binding pocket [chemical binding]; other site
634455008097	putative dimerization interface [polypeptide binding]; other site
634455008098	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634455008099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634455008100	Transposase; Region: HTH_Tnp_1; cl17663
634455008101	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634455008102	HTH-like domain; Region: HTH_21; pfam13276
634455008103	Integrase core domain; Region: rve; pfam00665
634455008104	Integrase core domain; Region: rve_3; pfam13683
634455008105	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634455008106	oligomeric interface; other site
634455008107	putative active site [active]
634455008108	homodimer interface [polypeptide binding]; other site
634455008109	Integrase core domain; Region: rve; pfam00665
634455008110	Winged helix-turn helix; Region: HTH_29; pfam13551
634455008111	Integrase core domain; Region: rve; pfam00665
634455008112	Transposase; Region: HTH_Tnp_1; pfam01527
634455008113	HTH-like domain; Region: HTH_21; pfam13276
634455008114	Integrase core domain; Region: rve; pfam00665
634455008115	Integrase core domain; Region: rve_3; pfam13683
634455008116	K+ potassium transporter; Region: K_trans; pfam02705
634455008117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634455008118	HTH-like domain; Region: HTH_21; pfam13276
634455008119	Integrase core domain; Region: rve; pfam00665
634455008120	Integrase core domain; Region: rve_3; pfam13683
634455008121	Transposase; Region: HTH_Tnp_1; pfam01527
634455008122	K+ potassium transporter; Region: K_trans; cl15781
634455008123	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455008124	Walker A motif; other site
634455008125	ATP binding site [chemical binding]; other site
634455008126	Walker B motif; other site
634455008127	arginine finger; other site
634455008128	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
634455008129	Integrase core domain; Region: rve; pfam00665
634455008130	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455008131	TrwC relaxase; Region: TrwC; pfam08751
634455008132	Integrase core domain; Region: rve; pfam00665
634455008133	Integrase core domain; Region: rve_3; pfam13683
634455008134	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455008135	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
634455008136	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
634455008137	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634455008138	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634455008139	catalytic residue [active]
634455008140	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
634455008141	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634455008142	Walker A motif; other site
634455008143	ATP binding site [chemical binding]; other site
634455008144	Walker B motif; other site
634455008145	RelB antitoxin; Region: RelB; cl01171
634455008146	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
634455008147	AAA-like domain; Region: AAA_10; pfam12846
634455008148	Transposase; Region: HTH_Tnp_1; pfam01527
634455008149	HTH-like domain; Region: HTH_21; pfam13276
634455008150	Integrase core domain; Region: rve; pfam00665
634455008151	Integrase core domain; Region: rve_3; pfam13683
634455008152	Protein of unknown function (DUF2859); Region: DUF2859; cl12633
634455008153	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455008154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634455008155	active site
634455008156	Transposase; Region: HTH_Tnp_1; cl17663
634455008157	HTH-like domain; Region: HTH_21; pfam13276
634455008158	Integrase core domain; Region: rve; pfam00665
634455008159	Integrase core domain; Region: rve_3; pfam13683
634455008160	Hint domain; Region: Hint_2; pfam13403
634455008161	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455008162	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455008163	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
634455008164	putative active site [active]
634455008165	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634455008166	HTH-like domain; Region: HTH_21; pfam13276
634455008167	Integrase core domain; Region: rve; pfam00665
634455008168	Integrase core domain; Region: rve_3; pfam13683
634455008169	Transposase; Region: HTH_Tnp_1; pfam01527
634455008170	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
634455008171	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
634455008172	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455008173	active site
634455008174	DNA binding site [nucleotide binding]
634455008175	Int/Topo IB signature motif; other site
634455008176	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634455008177	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634455008178	Outer membrane efflux protein; Region: OEP; pfam02321
634455008179	Outer membrane efflux protein; Region: OEP; pfam02321
634455008180	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
634455008181	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
634455008182	DNA binding residues [nucleotide binding]
634455008183	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
634455008184	dimer interface [polypeptide binding]; other site
634455008185	putative metal binding site [ion binding]; other site
634455008186	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634455008187	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
634455008188	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
634455008189	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634455008190	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
634455008191	Soluble P-type ATPase [General function prediction only]; Region: COG4087
634455008192	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
634455008193	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
634455008194	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
634455008195	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
634455008196	Ligand Binding Site [chemical binding]; other site
634455008197	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
634455008198	GAF domain; Region: GAF_3; pfam13492
634455008199	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634455008200	dimer interface [polypeptide binding]; other site
634455008201	phosphorylation site [posttranslational modification]
634455008202	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634455008203	ATP binding site [chemical binding]; other site
634455008204	Mg2+ binding site [ion binding]; other site
634455008205	G-X-G motif; other site
634455008206	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634455008207	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634455008208	active site
634455008209	phosphorylation site [posttranslational modification]
634455008210	intermolecular recognition site; other site
634455008211	dimerization interface [polypeptide binding]; other site
634455008212	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634455008213	DNA binding site [nucleotide binding]
634455008214	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634455008215	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634455008216	short chain dehydrogenase; Provisional; Region: PRK06180
634455008217	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
634455008218	NADP binding site [chemical binding]; other site
634455008219	active site
634455008220	steroid binding site; other site
634455008221	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
634455008222	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
634455008223	potential catalytic triad [active]
634455008224	conserved cys residue [active]
634455008225	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634455008226	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634455008227	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634455008228	ATP binding site [chemical binding]; other site
634455008229	putative Mg++ binding site [ion binding]; other site
634455008230	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634455008231	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
634455008232	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634455008233	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634455008234	Helix-turn-helix domain; Region: HTH_17; pfam12728
634455008235	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455008236	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634455008237	active site
634455008238	DNA binding site [nucleotide binding]
634455008239	Int/Topo IB signature motif; other site
634455008240	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
634455008241	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634455008242	oligomeric interface; other site
634455008243	putative active site [active]
634455008244	homodimer interface [polypeptide binding]; other site
634455008245	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
634455008246	Integrase core domain; Region: rve; pfam00665
634455008247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634455008248	Walker A motif; other site
634455008249	ATP binding site [chemical binding]; other site
634455008250	Walker B motif; other site
634455008251	arginine finger; other site
634455008252	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
634455008253	CcdB protein; Region: CcdB; cl03380
634455008254	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455008255	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455008256	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455008257	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634455008258	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
634455008259	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634455008260	Transposase; Region: HTH_Tnp_1; cl17663
634455008261	Helix-turn-helix domain; Region: HTH_28; pfam13518
634455008262	Winged helix-turn helix; Region: HTH_29; pfam13551
634455008263	Homeodomain-like domain; Region: HTH_32; pfam13565
634455008264	Integrase core domain; Region: rve; pfam00665
634455008265	Integrase core domain; Region: rve_3; pfam13683
634455008266	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
634455008267	ParB-like nuclease domain; Region: ParBc; pfam02195
634455008268	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
634455008269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634455008270	S-adenosylmethionine binding site [chemical binding]; other site
634455008271	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
634455008272	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634455008273	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
634455008274	helicase superfamily c-terminal domain; Region: HELICc; smart00490
634455008275	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634455008276	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455008277	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455008278	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
634455008279	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634455008280	active site
634455008281	DNA binding site [nucleotide binding]
634455008282	Int/Topo IB signature motif; other site
634455008283	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634455008284	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
634455008285	DDE superfamily endonuclease; Region: DDE_5; cl17874
634455008286	putative transposase OrfB; Reviewed; Region: PHA02517
634455008287	HTH-like domain; Region: HTH_21; pfam13276
634455008288	Integrase core domain; Region: rve; pfam00665
634455008289	Integrase core domain; Region: rve_3; pfam13683
634455008290	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634455008291	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455008292	catalytic residues [active]
634455008293	catalytic nucleophile [active]
634455008294	Presynaptic Site I dimer interface [polypeptide binding]; other site
634455008295	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634455008296	Synaptic Flat tetramer interface [polypeptide binding]; other site
634455008297	Synaptic Site I dimer interface [polypeptide binding]; other site
634455008298	DNA binding site [nucleotide binding]
634455008299	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455008300	DNA-binding interface [nucleotide binding]; DNA binding site
634455008301	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569
634455008302	Conjugal transfer protein TraD; Region: TraD; pfam06412
634455008303	putative transposase OrfB; Reviewed; Region: PHA02517
634455008304	HTH-like domain; Region: HTH_21; pfam13276
634455008305	Integrase core domain; Region: rve; pfam00665
634455008306	Integrase core domain; Region: rve_3; pfam13683
634455008307	Transposase; Region: HTH_Tnp_1; cl17663
634455008308	Hint domain; Region: Hint_2; pfam13403
634455008309	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634455008310	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634455008311	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634455008312	HTH-like domain; Region: HTH_21; pfam13276
634455008313	Integrase core domain; Region: rve; pfam00665
634455008314	Integrase core domain; Region: rve_3; pfam13683
634455008315	Transposase; Region: HTH_Tnp_1; pfam01527
634455008316	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634455008317	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634455008318	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455008319	DNA-binding interface [nucleotide binding]; DNA binding site
634455008320	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634455008321	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455008322	catalytic residues [active]
634455008323	catalytic nucleophile [active]
634455008324	Presynaptic Site I dimer interface [polypeptide binding]; other site
634455008325	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634455008326	Synaptic Flat tetramer interface [polypeptide binding]; other site
634455008327	Synaptic Site I dimer interface [polypeptide binding]; other site
634455008328	DNA binding site [nucleotide binding]
634455008329	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455008330	DNA-binding interface [nucleotide binding]; DNA binding site
634455008331	Winged helix-turn helix; Region: HTH_29; pfam13551
634455008332	Helix-turn-helix domain; Region: HTH_28; pfam13518
634455008333	Homeodomain-like domain; Region: HTH_32; pfam13565
634455008334	Integrase core domain; Region: rve; pfam00665
634455008335	Integrase core domain; Region: rve_3; cl15866
634455008336	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
634455008337	Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842
634455008338	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455008339	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634455008340	catalytic residues [active]
634455008341	catalytic nucleophile [active]
634455008342	Presynaptic Site I dimer interface [polypeptide binding]; other site
634455008343	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634455008344	Synaptic Flat tetramer interface [polypeptide binding]; other site
634455008345	Synaptic Site I dimer interface [polypeptide binding]; other site
634455008346	DNA binding site [nucleotide binding]
634455008347	ParA-like protein; Provisional; Region: PHA02518
634455008348	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634455008349	P-loop; other site
634455008350	Magnesium ion binding site [ion binding]; other site
634455008351	Replication initiator protein A; Region: RPA; pfam10134
634455008352	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
634455008353	putative addiction module antidote; Region: doc_partner; TIGR02609
634455008354	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
634455008355	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
634455008356	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
634455008357	putative active site [active]
634455008358	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
634455008359	Conjugal transfer protein TraD; Region: TraD; pfam06412
634455008360	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
634455008361	MobA/MobL family; Region: MobA_MobL; pfam03389
634455008362	AAA domain; Region: AAA_30; pfam13604
634455008363	Family description; Region: UvrD_C_2; pfam13538
634455008364	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
634455008365	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634455008366	oligomeric interface; other site
634455008367	putative active site [active]
634455008368	homodimer interface [polypeptide binding]; other site
634455008369	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
634455008370	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455008371	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634455008372	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455008373	catalytic residues [active]
634455008374	catalytic nucleophile [active]
634455008375	AAA domain; Region: AAA_31; pfam13614
634455008376	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634455008377	P-loop; other site
634455008378	Magnesium ion binding site [ion binding]; other site
634455008379	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
634455008380	non-specific DNA binding site [nucleotide binding]; other site
634455008381	salt bridge; other site
634455008382	sequence-specific DNA binding site [nucleotide binding]; other site
634455008383	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634455008384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634455008385	HTH-like domain; Region: HTH_21; pfam13276
634455008386	Integrase core domain; Region: rve; pfam00665
634455008387	Integrase core domain; Region: rve_3; pfam13683
634455008388	Transposase; Region: HTH_Tnp_1; pfam01527
634455008389	T5orf172 domain; Region: T5orf172; pfam10544
634455008390	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634455008391	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
634455008392	Pseudomurein-binding repeat; Region: PMBR; pfam09373
634455008393	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
634455008394	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634455008395	Fic family protein [Function unknown]; Region: COG3177
634455008396	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
634455008397	Fic/DOC family; Region: Fic; pfam02661
634455008398	PemK-like protein; Region: PemK; pfam02452
634455008399	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634455008400	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634455008401	Presynaptic Site I dimer interface [polypeptide binding]; other site
634455008402	catalytic residues [active]
634455008403	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634455008404	Synaptic Flat tetramer interface [polypeptide binding]; other site
634455008405	Synaptic Site I dimer interface [polypeptide binding]; other site
634455008406	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634455008407	DNA-binding interface [nucleotide binding]; DNA binding site
634455008408	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634455008409	Hint domain; Region: Hint_2; pfam13403
634455008410	Transposase; Region: HTH_Tnp_1; pfam01527
634455008411	HTH-like domain; Region: HTH_21; pfam13276
634455008412	Integrase core domain; Region: rve; pfam00665
634455008413	Integrase core domain; Region: rve_3; pfam13683
634455008414	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
634455008415	non-specific DNA binding site [nucleotide binding]; other site
634455008416	salt bridge; other site
634455008417	sequence-specific DNA binding site [nucleotide binding]; other site
634455008418	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634455008419	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634455008420	P-loop; other site
634455008421	Magnesium ion binding site [ion binding]; other site
634455008422	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
634455008423	Conjugal transfer protein TraD; Region: TraD; pfam06412
634455008424	MobA/MobL family; Region: MobA_MobL; pfam03389
634455008425	Helix-turn-helix domain; Region: HTH_36; pfam13730