-- dump date   	20140618_183528
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
634458000001	Transposase; Region: HTH_Tnp_1; pfam01527
634458000002	Integrase core domain; Region: rve_3; pfam13683
634458000003	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
634458000004	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634458000005	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634458000006	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634458000007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
634458000008	Transposase; Region: DEDD_Tnp_IS110; pfam01548
634458000009	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
634458000010	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634458000011	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458000012	catalytic residues [active]
634458000013	catalytic nucleophile [active]
634458000014	Presynaptic Site I dimer interface [polypeptide binding]; other site
634458000015	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634458000016	Synaptic Flat tetramer interface [polypeptide binding]; other site
634458000017	Synaptic Site I dimer interface [polypeptide binding]; other site
634458000018	DDE superfamily endonuclease; Region: DDE_4; cl17710
634458000019	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634458000020	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
634458000021	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
634458000022	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
634458000023	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
634458000024	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458000025	motif II; other site
634458000026	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
634458000027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458000028	Walker A/P-loop; other site
634458000029	ATP binding site [chemical binding]; other site
634458000030	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
634458000031	AAA domain; Region: AAA_12; pfam13087
634458000032	C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118
634458000033	PLD-like domain; Region: PLDc_2; pfam13091
634458000034	putative active site [active]
634458000035	catalytic site [active]
634458000036	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000037	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000038	Domain Homologous to E6-AP Carboxyl Terminus with; Region: HECTc; smart00119
634458000039	Transposase; Region: HTH_Tnp_1; pfam01527
634458000040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634458000041	HTH-like domain; Region: HTH_21; pfam13276
634458000042	Integrase core domain; Region: rve; pfam00665
634458000043	Integrase core domain; Region: rve_3; pfam13683
634458000044	conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346
634458000045	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634458000046	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000047	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458000048	DNA binding site [nucleotide binding]
634458000049	Int/Topo IB signature motif; other site
634458000050	active site
634458000051	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
634458000052	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458000053	non-specific DNA binding site [nucleotide binding]; other site
634458000054	salt bridge; other site
634458000055	sequence-specific DNA binding site [nucleotide binding]; other site
634458000056	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634458000057	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634458000058	P-loop; other site
634458000059	Magnesium ion binding site [ion binding]; other site
634458000060	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634458000061	Magnesium ion binding site [ion binding]; other site
634458000062	ParB-like nuclease domain; Region: ParBc; pfam02195
634458000063	KorB domain; Region: KorB; pfam08535
634458000064	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
634458000065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458000066	S-adenosylmethionine binding site [chemical binding]; other site
634458000067	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
634458000068	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
634458000069	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000070	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634458000071	IHF dimer interface [polypeptide binding]; other site
634458000072	IHF - DNA interface [nucleotide binding]; other site
634458000073	TrwC relaxase; Region: TrwC; pfam08751
634458000074	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000075	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000076	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000077	Transposase domain (DUF772); Region: DUF772; pfam05598
634458000078	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458000079	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458000080	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
634458000081	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
634458000082	dimer interface [polypeptide binding]; other site
634458000083	active site
634458000084	metal binding site [ion binding]; metal-binding site
634458000085	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634458000086	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634458000087	NAD(P) binding site [chemical binding]; other site
634458000088	catalytic residues [active]
634458000089	Integrase core domain; Region: rve; pfam00665
634458000090	Winged helix-turn helix; Region: HTH_29; pfam13551
634458000091	Integrase core domain; Region: rve; pfam00665
634458000092	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458000093	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634458000094	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
634458000095	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
634458000096	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634458000097	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
634458000098	Soluble P-type ATPase [General function prediction only]; Region: COG4087
634458000099	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
634458000100	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
634458000101	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
634458000102	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
634458000103	Ligand Binding Site [chemical binding]; other site
634458000104	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
634458000105	GAF domain; Region: GAF_3; pfam13492
634458000106	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458000107	dimer interface [polypeptide binding]; other site
634458000108	phosphorylation site [posttranslational modification]
634458000109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458000110	ATP binding site [chemical binding]; other site
634458000111	Mg2+ binding site [ion binding]; other site
634458000112	G-X-G motif; other site
634458000113	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634458000114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458000115	active site
634458000116	phosphorylation site [posttranslational modification]
634458000117	intermolecular recognition site; other site
634458000118	dimerization interface [polypeptide binding]; other site
634458000119	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458000120	DNA binding site [nucleotide binding]
634458000121	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634458000122	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000123	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
634458000124	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634458000125	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
634458000126	Acyltransferase family; Region: Acyl_transf_3; pfam01757
634458000127	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
634458000128	Fic/DOC family; Region: Fic; cl00960
634458000129	Replication protein C N-terminal domain; Region: RP-C; pfam03428
634458000130	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
634458000131	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000132	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458000133	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458000134	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
634458000135	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
634458000136	active site
634458000137	catalytic site [active]
634458000138	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
634458000139	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634458000140	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
634458000141	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634458000142	CrcB-like protein; Region: CRCB; cl09114
634458000143	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000144	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
634458000145	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000146	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000147	Transposase domain (DUF772); Region: DUF772; pfam05598
634458000148	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
634458000149	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
634458000150	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
634458000151	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000152	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458000153	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000154	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458000155	manganese transport protein MntH; Reviewed; Region: PRK00701
634458000156	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
634458000157	manganese transport regulator MntR; Provisional; Region: PRK11050
634458000158	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
634458000159	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
634458000160	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
634458000161	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
634458000162	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
634458000163	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634458000164	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
634458000165	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
634458000166	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
634458000167	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634458000168	iron-sulfur cluster [ion binding]; other site
634458000169	[2Fe-2S] cluster binding site [ion binding]; other site
634458000170	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000171	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
634458000172	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458000173	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458000174	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458000175	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458000176	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000177	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458000178	putative transposase OrfB; Reviewed; Region: PHA02517
634458000179	HTH-like domain; Region: HTH_21; pfam13276
634458000180	Integrase core domain; Region: rve; pfam00665
634458000181	Integrase core domain; Region: rve_3; pfam13683
634458000182	Transposase; Region: HTH_Tnp_1; cl17663
634458000183	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634458000184	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634458000185	Transposase domain (DUF772); Region: DUF772; pfam05598
634458000186	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000187	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634458000188	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
634458000189	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634458000190	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
634458000191	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
634458000192	CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485
634458000193	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
634458000194	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
634458000195	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693
634458000196	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
634458000197	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
634458000198	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
634458000199	Winged helix-turn helix; Region: HTH_29; pfam13551
634458000200	Integrase core domain; Region: rve; pfam00665
634458000201	Integrase core domain; Region: rve_3; pfam13683
634458000202	Predicted transcriptional regulator [Transcription]; Region: COG4190
634458000203	Abi-like protein; Region: Abi_2; pfam07751
634458000204	putative transposase OrfB; Reviewed; Region: PHA02517
634458000205	HTH-like domain; Region: HTH_21; pfam13276
634458000206	Integrase core domain; Region: rve; pfam00665
634458000207	Integrase core domain; Region: rve_3; pfam13683
634458000208	Transposase; Region: HTH_Tnp_1; cl17663
634458000209	Predicted membrane protein [Function unknown]; Region: COG3431
634458000210	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000211	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
634458000212	apolar tunnel; other site
634458000213	heme binding site [chemical binding]; other site
634458000214	dimerization interface [polypeptide binding]; other site
634458000215	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
634458000216	Transposase domain (DUF772); Region: DUF772; pfam05598
634458000217	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000218	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634458000219	HTH-like domain; Region: HTH_21; pfam13276
634458000220	Integrase core domain; Region: rve; pfam00665
634458000221	Integrase core domain; Region: rve_3; pfam13683
634458000222	Transposase; Region: HTH_Tnp_1; pfam01527
634458000223	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
634458000224	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
634458000225	Abi-like protein; Region: Abi_2; cl01988
634458000226	myosin-cross-reactive antigen; Provisional; Region: PRK13977
634458000227	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000228	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634458000229	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000230	Transposase domain (DUF772); Region: DUF772; pfam05598
634458000231	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
634458000232	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000233	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458000234	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
634458000235	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
634458000236	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458000237	Transposase domain (DUF772); Region: DUF772; pfam05598
634458000238	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000239	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634458000240	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634458000241	IHF dimer interface [polypeptide binding]; other site
634458000242	IHF - DNA interface [nucleotide binding]; other site
634458000243	putative transposase OrfB; Reviewed; Region: PHA02517
634458000244	HTH-like domain; Region: HTH_21; pfam13276
634458000245	Integrase core domain; Region: rve; pfam00665
634458000246	Integrase core domain; Region: rve_3; pfam13683
634458000247	Transposase; Region: HTH_Tnp_1; cl17663
634458000248	PemK-like protein; Region: PemK; cl00995
634458000249	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
634458000250	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634458000251	oligomeric interface; other site
634458000252	putative active site [active]
634458000253	homodimer interface [polypeptide binding]; other site
634458000254	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
634458000255	Integrase core domain; Region: rve_3; pfam13683
634458000256	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000257	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458000258	DNA-binding interface [nucleotide binding]; DNA binding site
634458000259	hypothetical protein; Provisional; Region: PRK10621
634458000260	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
634458000261	DDE superfamily endonuclease; Region: DDE_5; pfam13546
634458000262	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000263	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458000264	active site
634458000265	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
634458000266	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634458000267	acyl-activating enzyme (AAE) consensus motif; other site
634458000268	AMP binding site [chemical binding]; other site
634458000269	active site
634458000270	CoA binding site [chemical binding]; other site
634458000271	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
634458000272	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634458000273	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
634458000274	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
634458000275	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
634458000276	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
634458000277	dimerization interface [polypeptide binding]; other site
634458000278	putative ATP binding site [chemical binding]; other site
634458000279	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634458000280	Coenzyme A binding pocket [chemical binding]; other site
634458000281	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
634458000282	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458000283	FeS/SAM binding site; other site
634458000284	Predicted amidohydrolase [General function prediction only]; Region: COG0388
634458000285	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
634458000286	putative active site [active]
634458000287	catalytic triad [active]
634458000288	putative dimer interface [polypeptide binding]; other site
634458000289	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
634458000290	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
634458000291	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634458000292	DNA-binding site [nucleotide binding]; DNA binding site
634458000293	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458000294	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458000295	homodimer interface [polypeptide binding]; other site
634458000296	catalytic residue [active]
634458000297	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634458000298	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458000299	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458000300	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
634458000301	dimerization interface [polypeptide binding]; other site
634458000302	substrate binding pocket [chemical binding]; other site
634458000303	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634458000304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458000305	putative substrate translocation pore; other site
634458000306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458000307	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000308	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000309	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
634458000310	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
634458000311	AAA domain; Region: AAA_30; pfam13604
634458000312	Family description; Region: UvrD_C_2; pfam13538
634458000313	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
634458000314	active site
634458000315	catalytic residues [active]
634458000316	DNA binding site [nucleotide binding]
634458000317	Int/Topo IB signature motif; other site
634458000318	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000319	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458000320	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000321	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634458000322	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634458000323	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634458000324	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000325	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458000326	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458000327	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634458000328	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634458000329	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
634458000330	active site
634458000331	NTP binding site [chemical binding]; other site
634458000332	metal binding triad [ion binding]; metal-binding site
634458000333	antibiotic binding site [chemical binding]; other site
634458000334	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
634458000335	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634458000336	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
634458000337	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634458000338	S-adenosylmethionine binding site [chemical binding]; other site
634458000339	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
634458000340	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
634458000341	FMN binding site [chemical binding]; other site
634458000342	active site
634458000343	substrate binding site [chemical binding]; other site
634458000344	catalytic residue [active]
634458000345	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458000346	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634458000347	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000348	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458000349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458000350	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
634458000351	putative substrate binding pocket [chemical binding]; other site
634458000352	dimerization interface [polypeptide binding]; other site
634458000353	acetylornithine deacetylase; Provisional; Region: PRK07522
634458000354	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
634458000355	metal binding site [ion binding]; metal-binding site
634458000356	putative dimer interface [polypeptide binding]; other site
634458000357	choline dehydrogenase; Validated; Region: PRK02106
634458000358	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634458000359	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634458000360	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634458000361	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
634458000362	Na binding site [ion binding]; other site
634458000363	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
634458000364	homotrimer interaction site [polypeptide binding]; other site
634458000365	putative active site [active]
634458000366	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634458000367	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
634458000368	NAD(P) binding site [chemical binding]; other site
634458000369	catalytic residues [active]
634458000370	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
634458000371	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
634458000372	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
634458000373	Transposase; Region: HTH_Tnp_1; pfam01527
634458000374	HTH-like domain; Region: HTH_21; pfam13276
634458000375	Integrase core domain; Region: rve; pfam00665
634458000376	Integrase core domain; Region: rve_3; pfam13683
634458000377	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
634458000378	NMT1-like family; Region: NMT1_2; pfam13379
634458000379	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
634458000380	cheY-homologous receiver domain; Region: REC; smart00448
634458000381	ANTAR domain; Region: ANTAR; pfam03861
634458000382	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
634458000383	molybdopterin cofactor binding site; other site
634458000384	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
634458000385	molybdopterin cofactor binding site; other site
634458000386	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
634458000387	Flavodoxin; Region: Flavodoxin_1; pfam00258
634458000388	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
634458000389	FAD binding pocket [chemical binding]; other site
634458000390	conserved FAD binding motif [chemical binding]; other site
634458000391	phosphate binding motif [ion binding]; other site
634458000392	beta-alpha-beta structure motif; other site
634458000393	NAD binding pocket [chemical binding]; other site
634458000394	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000395	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458000396	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458000397	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
634458000398	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
634458000399	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634458000400	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
634458000401	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
634458000402	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
634458000403	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
634458000404	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
634458000405	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
634458000406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458000407	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
634458000408	sensor protein QseC; Provisional; Region: PRK10337
634458000409	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634458000410	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458000411	dimer interface [polypeptide binding]; other site
634458000412	phosphorylation site [posttranslational modification]
634458000413	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634458000414	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458000415	active site
634458000416	phosphorylation site [posttranslational modification]
634458000417	intermolecular recognition site; other site
634458000418	dimerization interface [polypeptide binding]; other site
634458000419	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458000420	DNA binding site [nucleotide binding]
634458000421	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634458000422	HlyD family secretion protein; Region: HlyD_2; pfam12700
634458000423	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458000424	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458000425	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634458000426	Outer membrane efflux protein; Region: OEP; pfam02321
634458000427	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634458000428	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458000429	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
634458000430	methionine synthase; Provisional; Region: PRK01207
634458000431	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
634458000432	substrate binding site [chemical binding]; other site
634458000433	THF binding site; other site
634458000434	zinc-binding site [ion binding]; other site
634458000435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458000436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458000437	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
634458000438	putative dimerization interface [polypeptide binding]; other site
634458000439	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458000440	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000441	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458000442	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458000443	non-specific DNA binding site [nucleotide binding]; other site
634458000444	salt bridge; other site
634458000445	sequence-specific DNA binding site [nucleotide binding]; other site
634458000446	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
634458000447	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
634458000448	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
634458000449	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
634458000450	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
634458000451	arsenical pump membrane protein; Provisional; Region: PRK15445
634458000452	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
634458000453	transmembrane helices; other site
634458000454	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634458000455	ArsC family; Region: ArsC; pfam03960
634458000456	catalytic residues [active]
634458000457	Protein of unknown function DUF45; Region: DUF45; pfam01863
634458000458	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634458000459	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634458000460	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458000461	ATP binding site [chemical binding]; other site
634458000462	putative Mg++ binding site [ion binding]; other site
634458000463	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634458000464	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634458000465	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
634458000466	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
634458000467	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634458000468	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634458000469	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
634458000470	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634458000471	HTH-like domain; Region: HTH_21; pfam13276
634458000472	Integrase core domain; Region: rve; pfam00665
634458000473	Integrase core domain; Region: rve_3; pfam13683
634458000474	Transposase; Region: HTH_Tnp_1; pfam01527
634458000475	CCC1-related family of proteins; Region: CCC1_like; cl00278
634458000476	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634458000477	ArsC family; Region: ArsC; pfam03960
634458000478	catalytic residues [active]
634458000479	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
634458000480	Transposase; Region: HTH_Tnp_1; cl17663
634458000481	putative transposase OrfB; Reviewed; Region: PHA02517
634458000482	HTH-like domain; Region: HTH_21; pfam13276
634458000483	Integrase core domain; Region: rve; pfam00665
634458000484	Integrase core domain; Region: rve_3; pfam13683
634458000485	Integrase core domain; Region: rve; pfam00665
634458000486	Integrase core domain; Region: rve_3; pfam13683
634458000487	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458000488	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458000489	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
634458000490	putative substrate binding pocket [chemical binding]; other site
634458000491	putative dimerization interface [polypeptide binding]; other site
634458000492	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634458000493	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458000494	Transposase; Region: HTH_Tnp_1; cl17663
634458000495	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634458000496	HTH-like domain; Region: HTH_21; pfam13276
634458000497	Integrase core domain; Region: rve; pfam00665
634458000498	Integrase core domain; Region: rve_3; pfam13683
634458000499	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634458000500	oligomeric interface; other site
634458000501	putative active site [active]
634458000502	homodimer interface [polypeptide binding]; other site
634458000503	Integrase core domain; Region: rve; pfam00665
634458000504	Winged helix-turn helix; Region: HTH_29; pfam13551
634458000505	Integrase core domain; Region: rve; pfam00665
634458000506	Transposase; Region: HTH_Tnp_1; pfam01527
634458000507	HTH-like domain; Region: HTH_21; pfam13276
634458000508	Integrase core domain; Region: rve; pfam00665
634458000509	Integrase core domain; Region: rve_3; pfam13683
634458000510	K+ potassium transporter; Region: K_trans; pfam02705
634458000511	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634458000512	HTH-like domain; Region: HTH_21; pfam13276
634458000513	Integrase core domain; Region: rve; pfam00665
634458000514	Integrase core domain; Region: rve_3; pfam13683
634458000515	Transposase; Region: HTH_Tnp_1; pfam01527
634458000516	K+ potassium transporter; Region: K_trans; cl15781
634458000517	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458000518	Walker A motif; other site
634458000519	ATP binding site [chemical binding]; other site
634458000520	Walker B motif; other site
634458000521	arginine finger; other site
634458000522	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
634458000523	Integrase core domain; Region: rve; pfam00665
634458000524	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000525	TrwC relaxase; Region: TrwC; pfam08751
634458000526	Integrase core domain; Region: rve; pfam00665
634458000527	Integrase core domain; Region: rve_3; pfam13683
634458000528	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000529	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
634458000530	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
634458000531	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634458000532	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634458000533	catalytic residue [active]
634458000534	Dot/Icm secretion system ATPase DotB; Region: dot_icm_DotB; TIGR02524
634458000535	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634458000536	Walker A motif; other site
634458000537	ATP binding site [chemical binding]; other site
634458000538	Walker B motif; other site
634458000539	RelB antitoxin; Region: RelB; cl01171
634458000540	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
634458000541	AAA-like domain; Region: AAA_10; pfam12846
634458000542	Transposase; Region: HTH_Tnp_1; pfam01527
634458000543	HTH-like domain; Region: HTH_21; pfam13276
634458000544	Integrase core domain; Region: rve; pfam00665
634458000545	Integrase core domain; Region: rve_3; pfam13683
634458000546	Protein of unknown function (DUF2859); Region: DUF2859; cl12633
634458000547	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000548	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458000549	active site
634458000550	Transposase; Region: HTH_Tnp_1; cl17663
634458000551	HTH-like domain; Region: HTH_21; pfam13276
634458000552	Integrase core domain; Region: rve; pfam00665
634458000553	Integrase core domain; Region: rve_3; pfam13683
634458000554	Hint domain; Region: Hint_2; pfam13403
634458000555	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458000556	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000557	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
634458000558	putative active site [active]
634458000559	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634458000560	HTH-like domain; Region: HTH_21; pfam13276
634458000561	Integrase core domain; Region: rve; pfam00665
634458000562	Integrase core domain; Region: rve_3; pfam13683
634458000563	Transposase; Region: HTH_Tnp_1; pfam01527
634458000564	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
634458000565	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
634458000566	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458000567	active site
634458000568	DNA binding site [nucleotide binding]
634458000569	Int/Topo IB signature motif; other site
634458000570	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634458000571	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634458000572	Outer membrane efflux protein; Region: OEP; pfam02321
634458000573	Outer membrane efflux protein; Region: OEP; pfam02321
634458000574	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
634458000575	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
634458000576	DNA binding residues [nucleotide binding]
634458000577	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
634458000578	dimer interface [polypeptide binding]; other site
634458000579	putative metal binding site [ion binding]; other site
634458000580	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634458000581	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
634458000582	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
634458000583	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634458000584	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
634458000585	Soluble P-type ATPase [General function prediction only]; Region: COG4087
634458000586	potassium-transporting ATPase subunit C; Provisional; Region: PRK13999
634458000587	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
634458000588	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
634458000589	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
634458000590	Ligand Binding Site [chemical binding]; other site
634458000591	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
634458000592	GAF domain; Region: GAF_3; pfam13492
634458000593	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458000594	dimer interface [polypeptide binding]; other site
634458000595	phosphorylation site [posttranslational modification]
634458000596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458000597	ATP binding site [chemical binding]; other site
634458000598	Mg2+ binding site [ion binding]; other site
634458000599	G-X-G motif; other site
634458000600	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634458000601	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458000602	active site
634458000603	phosphorylation site [posttranslational modification]
634458000604	intermolecular recognition site; other site
634458000605	dimerization interface [polypeptide binding]; other site
634458000606	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458000607	DNA binding site [nucleotide binding]
634458000608	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458000609	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458000610	short chain dehydrogenase; Provisional; Region: PRK06180
634458000611	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
634458000612	NADP binding site [chemical binding]; other site
634458000613	active site
634458000614	steroid binding site; other site
634458000615	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
634458000616	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
634458000617	potential catalytic triad [active]
634458000618	conserved cys residue [active]
634458000619	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
634458000620	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
634458000621	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458000622	ATP binding site [chemical binding]; other site
634458000623	putative Mg++ binding site [ion binding]; other site
634458000624	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
634458000625	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
634458000626	HsdM N-terminal domain; Region: HsdM_N; pfam12161
634458000627	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634458000628	Helix-turn-helix domain; Region: HTH_17; pfam12728
634458000629	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458000630	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634458000631	active site
634458000632	DNA binding site [nucleotide binding]
634458000633	Int/Topo IB signature motif; other site
634458000634	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
634458000635	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634458000636	oligomeric interface; other site
634458000637	putative active site [active]
634458000638	homodimer interface [polypeptide binding]; other site
634458000639	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
634458000640	Integrase core domain; Region: rve; pfam00665
634458000641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458000642	Walker A motif; other site
634458000643	ATP binding site [chemical binding]; other site
634458000644	Walker B motif; other site
634458000645	arginine finger; other site
634458000646	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
634458000647	CcdB protein; Region: CcdB; cl03380
634458000648	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458000649	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458000650	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458000651	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634458000652	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
634458000653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634458000654	Transposase; Region: HTH_Tnp_1; cl17663
634458000655	Helix-turn-helix domain; Region: HTH_28; pfam13518
634458000656	Winged helix-turn helix; Region: HTH_29; pfam13551
634458000657	Homeodomain-like domain; Region: HTH_32; pfam13565
634458000658	Integrase core domain; Region: rve; pfam00665
634458000659	Integrase core domain; Region: rve_3; pfam13683
634458000660	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
634458000661	ParB-like nuclease domain; Region: ParBc; pfam02195
634458000662	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
634458000663	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458000664	S-adenosylmethionine binding site [chemical binding]; other site
634458000665	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
634458000666	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634458000667	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
634458000668	helicase superfamily c-terminal domain; Region: HELICc; smart00490
634458000669	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458000670	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458000671	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458000672	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
634458000673	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458000674	active site
634458000675	DNA binding site [nucleotide binding]
634458000676	Int/Topo IB signature motif; other site
634458000677	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458000678	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
634458000679	DDE superfamily endonuclease; Region: DDE_5; cl17874
634458000680	putative transposase OrfB; Reviewed; Region: PHA02517
634458000681	HTH-like domain; Region: HTH_21; pfam13276
634458000682	Integrase core domain; Region: rve; pfam00665
634458000683	Integrase core domain; Region: rve_3; pfam13683
634458000684	Conjugal transfer protein TraD; Region: TraD; pfam06412
634458000685	MobA/MobL family; Region: MobA_MobL; pfam03389
634458000686	Helix-turn-helix domain; Region: HTH_36; pfam13730
634458000687	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
634458000688	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
634458000689	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
634458000690	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634458000691	active site
634458000692	Int/Topo IB signature motif; other site
634458000693	hypothetical protein; Validated; Region: PRK00124
634458000694	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
634458000695	dimer interface [polypeptide binding]; other site
634458000696	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
634458000697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458000698	putative substrate translocation pore; other site
634458000699	Uncharacterized conserved protein [Function unknown]; Region: COG2835
634458000700	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
634458000701	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
634458000702	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634458000703	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
634458000704	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
634458000705	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
634458000706	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
634458000707	Creatinine amidohydrolase; Region: Creatininase; pfam02633
634458000708	Uncharacterized conserved protein [Function unknown]; Region: COG3391
634458000709	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
634458000710	AAA ATPase domain; Region: AAA_16; pfam13191
634458000711	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
634458000712	Uncharacterized conserved protein [Function unknown]; Region: COG3410
634458000713	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
634458000714	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
634458000715	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
634458000716	putative FMN binding site [chemical binding]; other site
634458000717	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
634458000718	Glycoprotease family; Region: Peptidase_M22; pfam00814
634458000719	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634458000720	Coenzyme A binding pocket [chemical binding]; other site
634458000721	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
634458000722	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
634458000723	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
634458000724	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
634458000725	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
634458000726	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
634458000727	generic binding surface II; other site
634458000728	generic binding surface I; other site
634458000729	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
634458000730	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634458000731	catalytic residue [active]
634458000732	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634458000733	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634458000734	NAD(P) binding site [chemical binding]; other site
634458000735	catalytic residues [active]
634458000736	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634458000737	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
634458000738	NAD binding site [chemical binding]; other site
634458000739	substrate binding site [chemical binding]; other site
634458000740	catalytic Zn binding site [ion binding]; other site
634458000741	tetramer interface [polypeptide binding]; other site
634458000742	structural Zn binding site [ion binding]; other site
634458000743	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
634458000744	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
634458000745	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
634458000746	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
634458000747	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
634458000748	ligand binding site [chemical binding]; other site
634458000749	homodimer interface [polypeptide binding]; other site
634458000750	NAD(P) binding site [chemical binding]; other site
634458000751	trimer interface B [polypeptide binding]; other site
634458000752	trimer interface A [polypeptide binding]; other site
634458000753	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
634458000754	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
634458000755	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
634458000756	Iron-sulfur protein interface; other site
634458000757	proximal quinone binding site [chemical binding]; other site
634458000758	SdhD (CybS) interface [polypeptide binding]; other site
634458000759	proximal heme binding site [chemical binding]; other site
634458000760	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
634458000761	putative SdhC subunit interface [polypeptide binding]; other site
634458000762	putative proximal heme binding site [chemical binding]; other site
634458000763	putative Iron-sulfur protein interface [polypeptide binding]; other site
634458000764	putative proximal quinone binding site; other site
634458000765	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
634458000766	L-aspartate oxidase; Provisional; Region: PRK06175
634458000767	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
634458000768	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
634458000769	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
634458000770	Putative phosphatase (DUF442); Region: DUF442; cl17385
634458000771	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634458000772	EamA-like transporter family; Region: EamA; pfam00892
634458000773	Phosphoglycerate kinase; Region: PGK; pfam00162
634458000774	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
634458000775	substrate binding site [chemical binding]; other site
634458000776	hinge regions; other site
634458000777	ADP binding site [chemical binding]; other site
634458000778	catalytic site [active]
634458000779	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
634458000780	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
634458000781	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
634458000782	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
634458000783	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
634458000784	TPP-binding site [chemical binding]; other site
634458000785	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634458000786	PYR/PP interface [polypeptide binding]; other site
634458000787	dimer interface [polypeptide binding]; other site
634458000788	TPP binding site [chemical binding]; other site
634458000789	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634458000790	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
634458000791	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
634458000792	substrate-cofactor binding pocket; other site
634458000793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458000794	catalytic residue [active]
634458000795	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
634458000796	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
634458000797	catalytic residues [active]
634458000798	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
634458000799	recombinase A; Provisional; Region: recA; PRK09354
634458000800	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
634458000801	hexamer interface [polypeptide binding]; other site
634458000802	Walker A motif; other site
634458000803	ATP binding site [chemical binding]; other site
634458000804	Walker B motif; other site
634458000805	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
634458000806	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634458000807	Coenzyme A binding pocket [chemical binding]; other site
634458000808	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
634458000809	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
634458000810	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
634458000811	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
634458000812	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
634458000813	Ligand binding site; other site
634458000814	DXD motif; other site
634458000815	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
634458000816	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
634458000817	active site
634458000818	dimer interface [polypeptide binding]; other site
634458000819	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
634458000820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458000821	putative substrate translocation pore; other site
634458000822	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
634458000823	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458000824	Walker A motif; other site
634458000825	ATP binding site [chemical binding]; other site
634458000826	Walker B motif; other site
634458000827	arginine finger; other site
634458000828	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
634458000829	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
634458000830	hypothetical protein; Validated; Region: PRK00153
634458000831	recombination protein RecR; Reviewed; Region: recR; PRK00076
634458000832	RecR protein; Region: RecR; pfam02132
634458000833	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
634458000834	putative active site [active]
634458000835	putative metal-binding site [ion binding]; other site
634458000836	tetramer interface [polypeptide binding]; other site
634458000837	short chain dehydrogenase; Provisional; Region: PRK09134
634458000838	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458000839	NAD(P) binding site [chemical binding]; other site
634458000840	active site
634458000841	Dihydroneopterin aldolase; Region: FolB; pfam02152
634458000842	active site
634458000843	TIGR02300 family protein; Region: FYDLN_acid
634458000844	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
634458000845	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
634458000846	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
634458000847	hinge; other site
634458000848	active site
634458000849	cytidylate kinase; Provisional; Region: cmk; PRK00023
634458000850	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
634458000851	CMP-binding site; other site
634458000852	The sites determining sugar specificity; other site
634458000853	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
634458000854	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
634458000855	RNA binding site [nucleotide binding]; other site
634458000856	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
634458000857	RNA binding site [nucleotide binding]; other site
634458000858	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
634458000859	RNA binding site [nucleotide binding]; other site
634458000860	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
634458000861	RNA binding site [nucleotide binding]; other site
634458000862	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
634458000863	RNA binding site [nucleotide binding]; other site
634458000864	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
634458000865	RNA binding site [nucleotide binding]; other site
634458000866	Major royal jelly protein; Region: MRJP; pfam03022
634458000867	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
634458000868	active site
634458000869	dimerization interface [polypeptide binding]; other site
634458000870	ribonuclease PH; Reviewed; Region: rph; PRK00173
634458000871	Ribonuclease PH; Region: RNase_PH_bact; cd11362
634458000872	hexamer interface [polypeptide binding]; other site
634458000873	active site
634458000874	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
634458000875	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
634458000876	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
634458000877	Transglycosylase; Region: Transgly; pfam00912
634458000878	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
634458000879	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
634458000880	This domain is found in peptide chain release factors; Region: PCRF; smart00937
634458000881	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
634458000882	RF-1 domain; Region: RF-1; pfam00472
634458000883	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634458000884	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
634458000885	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634458000886	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634458000887	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634458000888	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634458000889	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
634458000890	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
634458000891	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
634458000892	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
634458000893	rod shape-determining protein MreC; Provisional; Region: PRK13922
634458000894	rod shape-determining protein MreC; Region: MreC; pfam04085
634458000895	rod shape-determining protein MreB; Provisional; Region: PRK13927
634458000896	MreB and similar proteins; Region: MreB_like; cd10225
634458000897	nucleotide binding site [chemical binding]; other site
634458000898	Mg binding site [ion binding]; other site
634458000899	putative protofilament interaction site [polypeptide binding]; other site
634458000900	RodZ interaction site [polypeptide binding]; other site
634458000901	2-isopropylmalate synthase; Validated; Region: PRK00915
634458000902	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
634458000903	active site
634458000904	catalytic residues [active]
634458000905	metal binding site [ion binding]; metal-binding site
634458000906	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
634458000907	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
634458000908	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
634458000909	Uncharacterized conserved protein [Function unknown]; Region: COG0398
634458000910	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
634458000911	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458000912	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
634458000913	putative substrate translocation pore; other site
634458000914	PAS fold; Region: PAS_7; pfam12860
634458000915	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634458000916	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458000917	dimer interface [polypeptide binding]; other site
634458000918	phosphorylation site [posttranslational modification]
634458000919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458000920	ATP binding site [chemical binding]; other site
634458000921	Mg2+ binding site [ion binding]; other site
634458000922	G-X-G motif; other site
634458000923	Response regulator receiver domain; Region: Response_reg; pfam00072
634458000924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458000925	active site
634458000926	phosphorylation site [posttranslational modification]
634458000927	intermolecular recognition site; other site
634458000928	dimerization interface [polypeptide binding]; other site
634458000929	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634458000930	active site
634458000931	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634458000932	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634458000933	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
634458000934	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
634458000935	MOFRL family; Region: MOFRL; pfam05161
634458000936	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
634458000937	ligand binding site [chemical binding]; other site
634458000938	active site
634458000939	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634458000940	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634458000941	Cytochrome c; Region: Cytochrom_C; pfam00034
634458000942	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
634458000943	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
634458000944	Trp docking motif [polypeptide binding]; other site
634458000945	cytochrome domain interface [polypeptide binding]; other site
634458000946	active site
634458000947	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634458000948	Cytochrome c; Region: Cytochrom_C; pfam00034
634458000949	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
634458000950	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
634458000951	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
634458000952	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
634458000953	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
634458000954	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
634458000955	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
634458000956	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
634458000957	D-pathway; other site
634458000958	Putative ubiquinol binding site [chemical binding]; other site
634458000959	Low-spin heme (heme b) binding site [chemical binding]; other site
634458000960	Putative water exit pathway; other site
634458000961	Binuclear center (heme o3/CuB) [ion binding]; other site
634458000962	K-pathway; other site
634458000963	Putative proton exit pathway; other site
634458000964	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
634458000965	Subunit I/III interface [polypeptide binding]; other site
634458000966	Subunit III/IV interface [polypeptide binding]; other site
634458000967	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
634458000968	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
634458000969	4Fe-4S binding domain; Region: Fer4; pfam00037
634458000970	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
634458000971	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634458000972	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458000973	nucleotide binding region [chemical binding]; other site
634458000974	ATP-binding site [chemical binding]; other site
634458000975	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
634458000976	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
634458000977	interface (dimer of trimers) [polypeptide binding]; other site
634458000978	Substrate-binding/catalytic site; other site
634458000979	Zn-binding sites [ion binding]; other site
634458000980	MarR family; Region: MarR; pfam01047
634458000981	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
634458000982	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
634458000983	Mg++ binding site [ion binding]; other site
634458000984	putative catalytic motif [active]
634458000985	putative substrate binding site [chemical binding]; other site
634458000986	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
634458000987	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
634458000988	NAD(P) binding site [chemical binding]; other site
634458000989	homodimer interface [polypeptide binding]; other site
634458000990	substrate binding site [chemical binding]; other site
634458000991	active site
634458000992	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
634458000993	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
634458000994	inhibitor-cofactor binding pocket; inhibition site
634458000995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458000996	catalytic residue [active]
634458000997	dihydroorotase; Validated; Region: PRK09060
634458000998	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634458000999	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
634458001000	active site
634458001001	glutathione reductase; Validated; Region: PRK06116
634458001002	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634458001003	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634458001004	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
634458001005	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
634458001006	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
634458001007	FAD binding pocket [chemical binding]; other site
634458001008	FAD binding motif [chemical binding]; other site
634458001009	phosphate binding motif [ion binding]; other site
634458001010	beta-alpha-beta structure motif; other site
634458001011	NAD binding pocket [chemical binding]; other site
634458001012	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634458001013	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458001014	ATP binding site [chemical binding]; other site
634458001015	putative Mg++ binding site [ion binding]; other site
634458001016	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634458001017	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458001018	nucleotide binding region [chemical binding]; other site
634458001019	ATP-binding site [chemical binding]; other site
634458001020	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
634458001021	short chain dehydrogenase; Provisional; Region: PRK06197
634458001022	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458001023	NAD(P) binding site [chemical binding]; other site
634458001024	active site
634458001025	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
634458001026	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
634458001027	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
634458001028	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
634458001029	malate dehydrogenase; Provisional; Region: PRK13529
634458001030	Malic enzyme, N-terminal domain; Region: malic; pfam00390
634458001031	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
634458001032	NAD(P) binding site [chemical binding]; other site
634458001033	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
634458001034	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
634458001035	putative homodimer interface [polypeptide binding]; other site
634458001036	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
634458001037	heterodimer interface [polypeptide binding]; other site
634458001038	homodimer interface [polypeptide binding]; other site
634458001039	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
634458001040	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
634458001041	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
634458001042	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
634458001043	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
634458001044	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
634458001045	beta subunit interaction interface [polypeptide binding]; other site
634458001046	Walker A motif; other site
634458001047	ATP binding site [chemical binding]; other site
634458001048	Walker B motif; other site
634458001049	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
634458001050	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
634458001051	core domain interface [polypeptide binding]; other site
634458001052	delta subunit interface [polypeptide binding]; other site
634458001053	epsilon subunit interface [polypeptide binding]; other site
634458001054	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
634458001055	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
634458001056	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
634458001057	alpha subunit interaction interface [polypeptide binding]; other site
634458001058	Walker A motif; other site
634458001059	ATP binding site [chemical binding]; other site
634458001060	Walker B motif; other site
634458001061	inhibitor binding site; inhibition site
634458001062	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
634458001063	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
634458001064	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
634458001065	gamma subunit interface [polypeptide binding]; other site
634458001066	epsilon subunit interface [polypeptide binding]; other site
634458001067	LBP interface [polypeptide binding]; other site
634458001068	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
634458001069	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
634458001070	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
634458001071	catalytic site [active]
634458001072	putative active site [active]
634458001073	putative substrate binding site [chemical binding]; other site
634458001074	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
634458001075	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
634458001076	substrate binding site [chemical binding]; other site
634458001077	ATP binding site [chemical binding]; other site
634458001078	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
634458001079	GcrA cell cycle regulator; Region: GcrA; cl11564
634458001080	GcrA cell cycle regulator; Region: GcrA; cl11564
634458001081	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
634458001082	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
634458001083	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458001084	Walker A/P-loop; other site
634458001085	ATP binding site [chemical binding]; other site
634458001086	Q-loop/lid; other site
634458001087	ABC transporter signature motif; other site
634458001088	Walker B; other site
634458001089	D-loop; other site
634458001090	H-loop/switch region; other site
634458001091	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
634458001092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458001093	dimer interface [polypeptide binding]; other site
634458001094	conserved gate region; other site
634458001095	putative PBP binding loops; other site
634458001096	ABC-ATPase subunit interface; other site
634458001097	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
634458001098	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458001099	dimer interface [polypeptide binding]; other site
634458001100	conserved gate region; other site
634458001101	putative PBP binding loops; other site
634458001102	ABC-ATPase subunit interface; other site
634458001103	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458001104	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
634458001105	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
634458001106	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
634458001107	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
634458001108	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
634458001109	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634458001110	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
634458001111	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
634458001112	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
634458001113	ethanolamine permease; Region: 2A0305; TIGR00908
634458001114	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
634458001115	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458001116	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458001117	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
634458001118	Protein export membrane protein; Region: SecD_SecF; cl14618
634458001119	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634458001120	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634458001121	DNA-binding site [nucleotide binding]; DNA binding site
634458001122	RNA-binding motif; other site
634458001123	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458001124	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458001125	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458001126	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634458001127	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634458001128	N-terminal plug; other site
634458001129	ligand-binding site [chemical binding]; other site
634458001130	hypothetical protein; Provisional; Region: PRK09945
634458001131	Hint domain; Region: Hint_2; pfam13403
634458001132	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634458001133	formamidase; Provisional; Region: amiF; PRK13287
634458001134	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
634458001135	multimer interface [polypeptide binding]; other site
634458001136	active site
634458001137	catalytic triad [active]
634458001138	dimer interface [polypeptide binding]; other site
634458001139	Response regulator receiver domain; Region: Response_reg; pfam00072
634458001140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458001141	active site
634458001142	phosphorylation site [posttranslational modification]
634458001143	intermolecular recognition site; other site
634458001144	dimerization interface [polypeptide binding]; other site
634458001145	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
634458001146	DNA binding residues [nucleotide binding]
634458001147	dimerization interface [polypeptide binding]; other site
634458001148	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634458001149	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634458001150	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458001151	dimer interface [polypeptide binding]; other site
634458001152	phosphorylation site [posttranslational modification]
634458001153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458001154	ATP binding site [chemical binding]; other site
634458001155	Mg2+ binding site [ion binding]; other site
634458001156	G-X-G motif; other site
634458001157	Response regulator receiver domain; Region: Response_reg; pfam00072
634458001158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458001159	active site
634458001160	phosphorylation site [posttranslational modification]
634458001161	intermolecular recognition site; other site
634458001162	dimerization interface [polypeptide binding]; other site
634458001163	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
634458001164	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
634458001165	putative ligand binding site [chemical binding]; other site
634458001166	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
634458001167	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
634458001168	TM-ABC transporter signature motif; other site
634458001169	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
634458001170	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
634458001171	TM-ABC transporter signature motif; other site
634458001172	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
634458001173	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
634458001174	Walker A/P-loop; other site
634458001175	ATP binding site [chemical binding]; other site
634458001176	Q-loop/lid; other site
634458001177	ABC transporter signature motif; other site
634458001178	Walker B; other site
634458001179	D-loop; other site
634458001180	H-loop/switch region; other site
634458001181	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
634458001182	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
634458001183	Walker A/P-loop; other site
634458001184	ATP binding site [chemical binding]; other site
634458001185	Q-loop/lid; other site
634458001186	ABC transporter signature motif; other site
634458001187	Walker B; other site
634458001188	D-loop; other site
634458001189	H-loop/switch region; other site
634458001190	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458001191	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
634458001192	Predicted transcriptional regulator [Transcription]; Region: COG2378
634458001193	WYL domain; Region: WYL; pfam13280
634458001194	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458001195	active site
634458001196	Int/Topo IB signature motif; other site
634458001197	DNA binding site [nucleotide binding]
634458001198	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458001199	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
634458001200	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458001201	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
634458001202	active site
634458001203	Catalytic domain of Protein Kinases; Region: PKc; cd00180
634458001204	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
634458001205	active site
634458001206	ATP binding site [chemical binding]; other site
634458001207	substrate binding site [chemical binding]; other site
634458001208	activation loop (A-loop); other site
634458001209	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
634458001210	Catalytic domain of Protein Kinases; Region: PKc; cd00180
634458001211	active site
634458001212	ATP binding site [chemical binding]; other site
634458001213	substrate binding site [chemical binding]; other site
634458001214	activation loop (A-loop); other site
634458001215	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458001216	active site
634458001217	Int/Topo IB signature motif; other site
634458001218	DNA binding site [nucleotide binding]
634458001219	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634458001220	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634458001221	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634458001222	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634458001223	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634458001224	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634458001225	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634458001226	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634458001227	Transposase; Region: HTH_Tnp_1; pfam01527
634458001228	Protein of unknown function DUF45; Region: DUF45; pfam01863
634458001229	hypothetical protein; Provisional; Region: PRK05170
634458001230	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
634458001231	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
634458001232	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458001233	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
634458001234	Walker A/P-loop; other site
634458001235	ATP binding site [chemical binding]; other site
634458001236	Q-loop/lid; other site
634458001237	ABC transporter signature motif; other site
634458001238	Walker B; other site
634458001239	D-loop; other site
634458001240	H-loop/switch region; other site
634458001241	TOBE domain; Region: TOBE_2; pfam08402
634458001242	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
634458001243	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
634458001244	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634458001245	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
634458001246	multidrug resistance protein MdtN; Provisional; Region: PRK10476
634458001247	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458001248	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458001249	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634458001250	hopanoid-associated phosphorylase; Region: HpnG; TIGR03468
634458001251	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
634458001252	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
634458001253	Active site cavity [active]
634458001254	catalytic acid [active]
634458001255	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
634458001256	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
634458001257	active site lid residues [active]
634458001258	substrate binding pocket [chemical binding]; other site
634458001259	catalytic residues [active]
634458001260	substrate-Mg2+ binding site; other site
634458001261	aspartate-rich region 1; other site
634458001262	aspartate-rich region 2; other site
634458001263	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
634458001264	active site lid residues [active]
634458001265	substrate binding pocket [chemical binding]; other site
634458001266	catalytic residues [active]
634458001267	substrate-Mg2+ binding site; other site
634458001268	aspartate-rich region 1; other site
634458001269	aspartate-rich region 2; other site
634458001270	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
634458001271	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634458001272	active site
634458001273	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634458001274	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
634458001275	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
634458001276	putative NADP binding site [chemical binding]; other site
634458001277	putative substrate binding site [chemical binding]; other site
634458001278	active site
634458001279	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
634458001280	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
634458001281	prephenate dehydrogenase; Validated; Region: PRK08507
634458001282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634458001283	TPR motif; other site
634458001284	TPR repeat; Region: TPR_11; pfam13414
634458001285	binding surface
634458001286	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458001287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458001288	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
634458001289	dimerization interface [polypeptide binding]; other site
634458001290	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
634458001291	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
634458001292	dimer interface [polypeptide binding]; other site
634458001293	decamer (pentamer of dimers) interface [polypeptide binding]; other site
634458001294	catalytic triad [active]
634458001295	peroxidatic and resolving cysteines [active]
634458001296	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
634458001297	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
634458001298	Uncharacterized conserved protein [Function unknown]; Region: COG2353
634458001299	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
634458001300	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
634458001301	putative active site [active]
634458001302	metal binding site [ion binding]; metal-binding site
634458001303	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
634458001304	dimer interface [polypeptide binding]; other site
634458001305	substrate binding site [chemical binding]; other site
634458001306	metal binding sites [ion binding]; metal-binding site
634458001307	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
634458001308	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458001309	Walker A/P-loop; other site
634458001310	ATP binding site [chemical binding]; other site
634458001311	Q-loop/lid; other site
634458001312	ABC transporter signature motif; other site
634458001313	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634458001314	ABC transporter; Region: ABC_tran_2; pfam12848
634458001315	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634458001316	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
634458001317	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
634458001318	Coenzyme A binding pocket [chemical binding]; other site
634458001319	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
634458001320	VacJ like lipoprotein; Region: VacJ; cl01073
634458001321	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
634458001322	putative metal binding site [ion binding]; other site
634458001323	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
634458001324	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634458001325	HSP70 interaction site [polypeptide binding]; other site
634458001326	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
634458001327	epoxyqueuosine reductase; Region: TIGR00276
634458001328	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
634458001329	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
634458001330	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
634458001331	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
634458001332	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
634458001333	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
634458001334	substrate binding site [chemical binding]; other site
634458001335	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
634458001336	FAD binding site [chemical binding]; other site
634458001337	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
634458001338	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
634458001339	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
634458001340	homodimer interface [polypeptide binding]; other site
634458001341	NADP binding site [chemical binding]; other site
634458001342	substrate binding site [chemical binding]; other site
634458001343	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
634458001344	Protein of unknown function, DUF482; Region: DUF482; pfam04339
634458001345	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
634458001346	homotrimer interaction site [polypeptide binding]; other site
634458001347	putative active site [active]
634458001348	TSCPD domain; Region: TSCPD; pfam12637
634458001349	NADH dehydrogenase; Validated; Region: PRK08183
634458001350	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
634458001351	mce related protein; Region: MCE; pfam02470
634458001352	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
634458001353	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458001354	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
634458001355	active site
634458001356	motif I; other site
634458001357	motif II; other site
634458001358	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
634458001359	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
634458001360	active site
634458001361	homotetramer interface [polypeptide binding]; other site
634458001362	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
634458001363	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634458001364	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
634458001365	Probable Catalytic site; other site
634458001366	metal-binding site
634458001367	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458001368	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
634458001369	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
634458001370	nudix motif; other site
634458001371	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634458001372	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
634458001373	active site
634458001374	catalytic tetrad [active]
634458001375	Helix-turn-helix domain; Region: HTH_17; pfam12728
634458001376	excinuclease ABC subunit B; Provisional; Region: PRK05298
634458001377	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458001378	ATP binding site [chemical binding]; other site
634458001379	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458001380	nucleotide binding region [chemical binding]; other site
634458001381	ATP-binding site [chemical binding]; other site
634458001382	Ultra-violet resistance protein B; Region: UvrB; pfam12344
634458001383	UvrB/uvrC motif; Region: UVR; pfam02151
634458001384	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
634458001385	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634458001386	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
634458001387	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634458001388	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634458001389	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634458001390	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
634458001391	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458001392	active site
634458001393	motif I; other site
634458001394	motif II; other site
634458001395	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634458001396	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
634458001397	active site
634458001398	L-asparagine permease; Provisional; Region: PRK15049
634458001399	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
634458001400	active site
634458001401	DNA polymerase IV; Validated; Region: PRK02406
634458001402	DNA binding site [nucleotide binding]
634458001403	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
634458001404	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
634458001405	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
634458001406	quinone interaction residues [chemical binding]; other site
634458001407	active site
634458001408	catalytic residues [active]
634458001409	FMN binding site [chemical binding]; other site
634458001410	substrate binding site [chemical binding]; other site
634458001411	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
634458001412	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458001413	active site
634458001414	motif I; other site
634458001415	motif II; other site
634458001416	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458001417	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
634458001418	nudix motif; other site
634458001419	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
634458001420	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
634458001421	putative active site [active]
634458001422	metal binding site [ion binding]; metal-binding site
634458001423	homodimer binding site [polypeptide binding]; other site
634458001424	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
634458001425	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
634458001426	Cell division protein ZapA; Region: ZapA; cl01146
634458001427	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
634458001428	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
634458001429	putative active site; other site
634458001430	catalytic residue [active]
634458001431	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
634458001432	thiamine phosphate binding site [chemical binding]; other site
634458001433	active site
634458001434	pyrophosphate binding site [ion binding]; other site
634458001435	Prophage antirepressor [Transcription]; Region: COG3617
634458001436	BRO family, N-terminal domain; Region: Bro-N; smart01040
634458001437	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
634458001438	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
634458001439	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
634458001440	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458001441	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
634458001442	Transposase; Region: DDE_Tnp_ISL3; pfam01610
634458001443	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458001444	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458001445	Transposase; Region: DDE_Tnp_ISL3; pfam01610
634458001446	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634458001447	Fasciclin domain; Region: Fasciclin; cl02663
634458001448	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634458001449	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
634458001450	motif 1; other site
634458001451	dimer interface [polypeptide binding]; other site
634458001452	active site
634458001453	motif 2; other site
634458001454	motif 3; other site
634458001455	Radical SAM superfamily; Region: Radical_SAM; pfam04055
634458001456	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458001457	FeS/SAM binding site; other site
634458001458	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
634458001459	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
634458001460	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
634458001461	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
634458001462	active site
634458001463	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
634458001464	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
634458001465	Uncharacterized conserved protein [Function unknown]; Region: COG2127
634458001466	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
634458001467	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458001468	Walker A motif; other site
634458001469	ATP binding site [chemical binding]; other site
634458001470	Walker B motif; other site
634458001471	arginine finger; other site
634458001472	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458001473	Walker A motif; other site
634458001474	ATP binding site [chemical binding]; other site
634458001475	Walker B motif; other site
634458001476	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
634458001477	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
634458001478	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
634458001479	Putative transcriptional regulator [Transcription]; Region: COG1678
634458001480	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
634458001481	Shikimate kinase; Region: SKI; pfam01202
634458001482	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
634458001483	homotrimer interaction site [polypeptide binding]; other site
634458001484	putative active site [active]
634458001485	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
634458001486	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
634458001487	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634458001488	HAMP domain; Region: HAMP; pfam00672
634458001489	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458001490	dimer interface [polypeptide binding]; other site
634458001491	phosphorylation site [posttranslational modification]
634458001492	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458001493	ATP binding site [chemical binding]; other site
634458001494	Mg2+ binding site [ion binding]; other site
634458001495	G-X-G motif; other site
634458001496	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634458001497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458001498	active site
634458001499	phosphorylation site [posttranslational modification]
634458001500	intermolecular recognition site; other site
634458001501	dimerization interface [polypeptide binding]; other site
634458001502	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458001503	DNA binding site [nucleotide binding]
634458001504	GrpE; Region: GrpE; pfam01025
634458001505	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
634458001506	dimer interface [polypeptide binding]; other site
634458001507	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
634458001508	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
634458001509	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
634458001510	nucleotide binding site [chemical binding]; other site
634458001511	NEF interaction site [polypeptide binding]; other site
634458001512	SBD interface [polypeptide binding]; other site
634458001513	chaperone protein DnaJ; Provisional; Region: PRK10767
634458001514	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634458001515	HSP70 interaction site [polypeptide binding]; other site
634458001516	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
634458001517	Zn binding sites [ion binding]; other site
634458001518	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
634458001519	dimer interface [polypeptide binding]; other site
634458001520	dihydrodipicolinate reductase; Provisional; Region: PRK00048
634458001521	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
634458001522	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
634458001523	S-adenosylmethionine synthetase; Validated; Region: PRK05250
634458001524	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
634458001525	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
634458001526	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
634458001527	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
634458001528	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
634458001529	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
634458001530	purine monophosphate binding site [chemical binding]; other site
634458001531	dimer interface [polypeptide binding]; other site
634458001532	putative catalytic residues [active]
634458001533	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
634458001534	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634458001535	EamA-like transporter family; Region: EamA; pfam00892
634458001536	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
634458001537	DALR anticodon binding domain; Region: DALR_1; pfam05746
634458001538	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
634458001539	dimer interface [polypeptide binding]; other site
634458001540	motif 1; other site
634458001541	active site
634458001542	motif 2; other site
634458001543	motif 3; other site
634458001544	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
634458001545	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634458001546	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458001547	non-specific DNA binding site [nucleotide binding]; other site
634458001548	salt bridge; other site
634458001549	sequence-specific DNA binding site [nucleotide binding]; other site
634458001550	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
634458001551	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
634458001552	putative active site [active]
634458001553	catalytic triad [active]
634458001554	putative dimer interface [polypeptide binding]; other site
634458001555	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
634458001556	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
634458001557	metal binding site 2 [ion binding]; metal-binding site
634458001558	putative DNA binding helix; other site
634458001559	metal binding site 1 [ion binding]; metal-binding site
634458001560	dimer interface [polypeptide binding]; other site
634458001561	structural Zn2+ binding site [ion binding]; other site
634458001562	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
634458001563	CPxP  motif; other site
634458001564	transcription termination factor Rho; Provisional; Region: rho; PRK09376
634458001565	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
634458001566	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
634458001567	RNA binding site [nucleotide binding]; other site
634458001568	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
634458001569	multimer interface [polypeptide binding]; other site
634458001570	Walker A motif; other site
634458001571	ATP binding site [chemical binding]; other site
634458001572	Walker B motif; other site
634458001573	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
634458001574	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
634458001575	oligomer interface [polypeptide binding]; other site
634458001576	Cl binding site [ion binding]; other site
634458001577	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
634458001578	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
634458001579	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458001580	catalytic residue [active]
634458001581	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
634458001582	substrate binding site [chemical binding]; other site
634458001583	active site
634458001584	catalytic residues [active]
634458001585	heterodimer interface [polypeptide binding]; other site
634458001586	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
634458001587	HerA helicase [Replication, recombination, and repair]; Region: COG0433
634458001588	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
634458001589	Walker A motif; other site
634458001590	ATP binding site [chemical binding]; other site
634458001591	Walker B motif; other site
634458001592	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
634458001593	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
634458001594	dimer interface [polypeptide binding]; other site
634458001595	motif 1; other site
634458001596	active site
634458001597	motif 2; other site
634458001598	motif 3; other site
634458001599	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
634458001600	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
634458001601	GDP-binding site [chemical binding]; other site
634458001602	ACT binding site; other site
634458001603	IMP binding site; other site
634458001604	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
634458001605	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458001606	active site
634458001607	phosphorylation site [posttranslational modification]
634458001608	intermolecular recognition site; other site
634458001609	dimerization interface [polypeptide binding]; other site
634458001610	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458001611	DNA binding site [nucleotide binding]
634458001612	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
634458001613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458001614	dimer interface [polypeptide binding]; other site
634458001615	phosphorylation site [posttranslational modification]
634458001616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458001617	ATP binding site [chemical binding]; other site
634458001618	Mg2+ binding site [ion binding]; other site
634458001619	G-X-G motif; other site
634458001620	PBP superfamily domain; Region: PBP_like_2; cl17296
634458001621	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
634458001622	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
634458001623	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634458001624	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
634458001625	catalytic core [active]
634458001626	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
634458001627	Domain of unknown function DUF21; Region: DUF21; pfam01595
634458001628	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634458001629	Transporter associated domain; Region: CorC_HlyC; smart01091
634458001630	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
634458001631	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
634458001632	NADP binding site [chemical binding]; other site
634458001633	dimer interface [polypeptide binding]; other site
634458001634	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
634458001635	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
634458001636	putative active site [active]
634458001637	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634458001638	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
634458001639	Walker A/P-loop; other site
634458001640	ATP binding site [chemical binding]; other site
634458001641	Q-loop/lid; other site
634458001642	ABC transporter signature motif; other site
634458001643	Walker B; other site
634458001644	D-loop; other site
634458001645	H-loop/switch region; other site
634458001646	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
634458001647	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458001648	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458001649	Hint domain; Region: Hint_2; pfam13403
634458001650	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
634458001651	classical (c) SDRs; Region: SDR_c; cd05233
634458001652	NAD(P) binding site [chemical binding]; other site
634458001653	active site
634458001654	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
634458001655	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
634458001656	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
634458001657	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
634458001658	homodimer interface [polypeptide binding]; other site
634458001659	metal binding site [ion binding]; metal-binding site
634458001660	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
634458001661	homodimer interface [polypeptide binding]; other site
634458001662	active site
634458001663	putative chemical substrate binding site [chemical binding]; other site
634458001664	metal binding site [ion binding]; metal-binding site
634458001665	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634458001666	heat shock protein 90; Provisional; Region: PRK05218
634458001667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458001668	ATP binding site [chemical binding]; other site
634458001669	Mg2+ binding site [ion binding]; other site
634458001670	G-X-G motif; other site
634458001671	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
634458001672	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458001673	DNA binding site [nucleotide binding]
634458001674	active site
634458001675	Int/Topo IB signature motif; other site
634458001676	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
634458001677	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458001678	CotH protein; Region: CotH; pfam08757
634458001679	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
634458001680	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
634458001681	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
634458001682	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
634458001683	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
634458001684	active site
634458001685	substrate binding site [chemical binding]; other site
634458001686	Mg2+ binding site [ion binding]; other site
634458001687	hypothetical protein; Provisional; Region: PRK09272
634458001688	hypothetical protein; Provisional; Region: PRK10316
634458001689	YfdX protein; Region: YfdX; pfam10938
634458001690	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634458001691	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458001692	sequence-specific DNA binding site [nucleotide binding]; other site
634458001693	salt bridge; other site
634458001694	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
634458001695	Domain of unknown function (DUF955); Region: DUF955; pfam06114
634458001696	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
634458001697	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
634458001698	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
634458001699	methylcitrate synthase; Provisional; Region: PRK12351
634458001700	oxalacetate binding site [chemical binding]; other site
634458001701	citrylCoA binding site [chemical binding]; other site
634458001702	coenzyme A binding site [chemical binding]; other site
634458001703	catalytic triad [active]
634458001704	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
634458001705	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
634458001706	tetramer interface [polypeptide binding]; other site
634458001707	active site
634458001708	Mg2+/Mn2+ binding site [ion binding]; other site
634458001709	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634458001710	acetyl-CoA synthetase; Provisional; Region: PRK00174
634458001711	acyl-activating enzyme (AAE) consensus motif; other site
634458001712	AMP binding site [chemical binding]; other site
634458001713	active site
634458001714	CoA binding site [chemical binding]; other site
634458001715	putative sialic acid transporter; Region: 2A0112; TIGR00891
634458001716	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458001717	putative substrate translocation pore; other site
634458001718	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
634458001719	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
634458001720	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
634458001721	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
634458001722	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
634458001723	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
634458001724	dimer interface [polypeptide binding]; other site
634458001725	anticodon binding site; other site
634458001726	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
634458001727	homodimer interface [polypeptide binding]; other site
634458001728	motif 1; other site
634458001729	active site
634458001730	motif 2; other site
634458001731	GAD domain; Region: GAD; pfam02938
634458001732	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634458001733	active site
634458001734	motif 3; other site
634458001735	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
634458001736	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
634458001737	tetramer interface [polypeptide binding]; other site
634458001738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458001739	catalytic residue [active]
634458001740	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
634458001741	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
634458001742	5S rRNA interface [nucleotide binding]; other site
634458001743	CTC domain interface [polypeptide binding]; other site
634458001744	L16 interface [polypeptide binding]; other site
634458001745	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
634458001746	putative active site [active]
634458001747	catalytic residue [active]
634458001748	GTP-binding protein YchF; Reviewed; Region: PRK09601
634458001749	YchF GTPase; Region: YchF; cd01900
634458001750	G1 box; other site
634458001751	GTP/Mg2+ binding site [chemical binding]; other site
634458001752	Switch I region; other site
634458001753	G2 box; other site
634458001754	Switch II region; other site
634458001755	G3 box; other site
634458001756	G4 box; other site
634458001757	G5 box; other site
634458001758	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
634458001759	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
634458001760	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
634458001761	putative catalytic cysteine [active]
634458001762	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
634458001763	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
634458001764	active site
634458001765	(T/H)XGH motif; other site
634458001766	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
634458001767	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
634458001768	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
634458001769	Rhodanese-like domain; Region: Rhodanese; pfam00581
634458001770	active site residue [active]
634458001771	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
634458001772	active site residue [active]
634458001773	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458001774	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458001775	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
634458001776	putative dimerization interface [polypeptide binding]; other site
634458001777	putative substrate binding pocket [chemical binding]; other site
634458001778	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
634458001779	acetolactate synthase; Reviewed; Region: PRK08617
634458001780	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634458001781	PYR/PP interface [polypeptide binding]; other site
634458001782	dimer interface [polypeptide binding]; other site
634458001783	TPP binding site [chemical binding]; other site
634458001784	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634458001785	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
634458001786	TPP-binding site [chemical binding]; other site
634458001787	benzoylformate decarboxylase; Reviewed; Region: PRK07092
634458001788	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634458001789	PYR/PP interface [polypeptide binding]; other site
634458001790	dimer interface [polypeptide binding]; other site
634458001791	TPP binding site [chemical binding]; other site
634458001792	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634458001793	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
634458001794	TPP-binding site [chemical binding]; other site
634458001795	dimer interface [polypeptide binding]; other site
634458001796	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
634458001797	Cysteine-rich domain; Region: CCG; pfam02754
634458001798	Cysteine-rich domain; Region: CCG; pfam02754
634458001799	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
634458001800	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
634458001801	4Fe-4S binding domain; Region: Fer4; pfam00037
634458001802	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
634458001803	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
634458001804	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
634458001805	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
634458001806	hinge; other site
634458001807	active site
634458001808	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
634458001809	trimer interface [polypeptide binding]; other site
634458001810	active site
634458001811	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634458001812	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
634458001813	putative active site [active]
634458001814	YdjC motif; other site
634458001815	Mg binding site [ion binding]; other site
634458001816	putative homodimer interface [polypeptide binding]; other site
634458001817	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
634458001818	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
634458001819	B12 binding site [chemical binding]; other site
634458001820	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458001821	FeS/SAM binding site; other site
634458001822	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
634458001823	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
634458001824	ligand binding site; other site
634458001825	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
634458001826	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
634458001827	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
634458001828	TPP-binding site; other site
634458001829	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634458001830	PYR/PP interface [polypeptide binding]; other site
634458001831	dimer interface [polypeptide binding]; other site
634458001832	TPP binding site [chemical binding]; other site
634458001833	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634458001834	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
634458001835	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458001836	FeS/SAM binding site; other site
634458001837	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
634458001838	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
634458001839	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
634458001840	Domain of unknown function DUF21; Region: DUF21; pfam01595
634458001841	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634458001842	Transporter associated domain; Region: CorC_HlyC; smart01091
634458001843	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634458001844	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634458001845	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634458001846	catalytic residue [active]
634458001847	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
634458001848	Fe-S cluster binding site [ion binding]; other site
634458001849	active site
634458001850	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
634458001851	binding surface
634458001852	TPR motif; other site
634458001853	Tetratricopeptide repeat; Region: TPR_12; pfam13424
634458001854	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634458001855	TPR motif; other site
634458001856	TPR repeat; Region: TPR_11; pfam13414
634458001857	binding surface
634458001858	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
634458001859	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458001860	NAD(P) binding site [chemical binding]; other site
634458001861	active site
634458001862	Predicted membrane protein [Function unknown]; Region: COG1238
634458001863	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
634458001864	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
634458001865	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
634458001866	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
634458001867	Walker A/P-loop; other site
634458001868	ATP binding site [chemical binding]; other site
634458001869	Q-loop/lid; other site
634458001870	ABC transporter signature motif; other site
634458001871	Walker B; other site
634458001872	D-loop; other site
634458001873	H-loop/switch region; other site
634458001874	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
634458001875	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
634458001876	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
634458001877	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
634458001878	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634458001879	active site
634458001880	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634458001881	catalytic core [active]
634458001882	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
634458001883	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458001884	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458001885	short chain dehydrogenase; Provisional; Region: PRK12744
634458001886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458001887	NAD(P) binding site [chemical binding]; other site
634458001888	active site
634458001889	transcriptional regulator; Provisional; Region: PRK10632
634458001890	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458001891	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
634458001892	putative effector binding pocket; other site
634458001893	putative dimerization interface [polypeptide binding]; other site
634458001894	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634458001895	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
634458001896	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
634458001897	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634458001898	N-terminal plug; other site
634458001899	ligand-binding site [chemical binding]; other site
634458001900	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634458001901	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
634458001902	intersubunit interface [polypeptide binding]; other site
634458001903	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
634458001904	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
634458001905	putative PBP binding regions; other site
634458001906	ABC-ATPase subunit  interface; other site
634458001907	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
634458001908	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
634458001909	Walker A/P-loop; other site
634458001910	ATP binding site [chemical binding]; other site
634458001911	Q-loop/lid; other site
634458001912	ABC transporter signature motif; other site
634458001913	Walker B; other site
634458001914	D-loop; other site
634458001915	H-loop/switch region; other site
634458001916	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
634458001917	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
634458001918	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
634458001919	active site
634458001920	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634458001921	nucleotide binding site [chemical binding]; other site
634458001922	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
634458001923	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
634458001924	putative active site [active]
634458001925	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
634458001926	Na binding site [ion binding]; other site
634458001927	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634458001928	long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584
634458001929	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458001930	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458001931	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458001932	Hint domain; Region: Hint_2; pfam13403
634458001933	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
634458001934	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
634458001935	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
634458001936	DNA binding residues [nucleotide binding]
634458001937	dimerization interface [polypeptide binding]; other site
634458001938	Hint domain; Region: Hint_2; pfam13403
634458001939	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
634458001940	DNA photolyase; Region: DNA_photolyase; pfam00875
634458001941	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
634458001942	SelR domain; Region: SelR; pfam01641
634458001943	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
634458001944	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634458001945	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634458001946	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
634458001947	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458001948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458001949	homodimer interface [polypeptide binding]; other site
634458001950	catalytic residue [active]
634458001951	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458001952	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458001953	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458001954	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458001955	Hint domain; Region: Hint_2; pfam13403
634458001956	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
634458001957	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
634458001958	dimerization interface [polypeptide binding]; other site
634458001959	DPS ferroxidase diiron center [ion binding]; other site
634458001960	ion pore; other site
634458001961	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
634458001962	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
634458001963	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
634458001964	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
634458001965	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
634458001966	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
634458001967	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458001968	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458001969	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634458001970	dimerization interface [polypeptide binding]; other site
634458001971	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
634458001972	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
634458001973	Methylamine utilisation protein MauE; Region: MauE; pfam07291
634458001974	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634458001975	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
634458001976	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
634458001977	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634458001978	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634458001979	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634458001980	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
634458001981	active site
634458001982	catalytic tetrad [active]
634458001983	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458001984	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458001985	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634458001986	dimerization interface [polypeptide binding]; other site
634458001987	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
634458001988	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634458001989	NAD binding site [chemical binding]; other site
634458001990	catalytic residues [active]
634458001991	substrate binding site [chemical binding]; other site
634458001992	Cytochrome c; Region: Cytochrom_C; cl11414
634458001993	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634458001994	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634458001995	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634458001996	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
634458001997	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634458001998	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634458001999	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634458002000	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
634458002001	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634458002002	catalytic loop [active]
634458002003	iron binding site [ion binding]; other site
634458002004	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634458002005	Protein of unknown function (DUF563); Region: DUF563; pfam04577
634458002006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458002007	S-adenosylmethionine binding site [chemical binding]; other site
634458002008	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
634458002009	Hint domain; Region: Hint_2; pfam13403
634458002010	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458002011	putative substrate translocation pore; other site
634458002012	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634458002013	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
634458002014	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458002015	Predicted integral membrane protein [Function unknown]; Region: COG0762
634458002016	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634458002017	Protein of unknown function (DUF805); Region: DUF805; pfam05656
634458002018	CHRD domain; Region: CHRD; pfam07452
634458002019	Predicted membrane protein [Function unknown]; Region: COG3650
634458002020	META domain; Region: META; pfam03724
634458002021	Hint domain; Region: Hint_2; pfam13403
634458002022	T5orf172 domain; Region: T5orf172; pfam10544
634458002023	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
634458002024	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634458002025	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634458002026	N-terminal plug; other site
634458002027	ligand-binding site [chemical binding]; other site
634458002028	Cytochrome c; Region: Cytochrom_C; pfam00034
634458002029	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
634458002030	FAD dependent oxidoreductase; Region: DAO; pfam01266
634458002031	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458002032	NmrA-like family; Region: NmrA; pfam05368
634458002033	NAD(P) binding site [chemical binding]; other site
634458002034	active site
634458002035	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
634458002036	Hint domain; Region: Hint_2; pfam13403
634458002037	Hint domain; Region: Hint_2; pfam13403
634458002038	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
634458002039	Hint domain; Region: Hint_2; pfam13403
634458002040	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458002041	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634458002042	non-specific DNA binding site [nucleotide binding]; other site
634458002043	salt bridge; other site
634458002044	sequence-specific DNA binding site [nucleotide binding]; other site
634458002045	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634458002046	Catalytic site [active]
634458002047	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
634458002048	Hint domain; Region: Hint_2; pfam13403
634458002049	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634458002050	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634458002051	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458002052	DNA-binding interface [nucleotide binding]; DNA binding site
634458002053	Hint domain; Region: Hint_2; pfam13403
634458002054	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
634458002055	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
634458002056	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458002057	FeS/SAM binding site; other site
634458002058	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
634458002059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
634458002060	Terminase-like family; Region: Terminase_6; pfam03237
634458002061	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
634458002062	hypothetical protein; Validated; Region: PRK01415
634458002063	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
634458002064	active site residue [active]
634458002065	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
634458002066	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
634458002067	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
634458002068	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
634458002069	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
634458002070	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
634458002071	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
634458002072	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458002073	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
634458002074	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
634458002075	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634458002076	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458002077	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458002078	Phosphotransferase enzyme family; Region: APH; pfam01636
634458002079	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
634458002080	substrate binding site [chemical binding]; other site
634458002081	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
634458002082	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
634458002083	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
634458002084	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
634458002085	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
634458002086	putative active site [active]
634458002087	putative substrate binding site [chemical binding]; other site
634458002088	putative cosubstrate binding site; other site
634458002089	catalytic site [active]
634458002090	Uncharacterized conserved protein [Function unknown]; Region: COG3189
634458002091	Predicted transcriptional regulator [Transcription]; Region: COG1959
634458002092	Transcriptional regulator; Region: Rrf2; cl17282
634458002093	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458002094	malonic semialdehyde reductase; Provisional; Region: PRK10538
634458002095	NAD(P) binding site [chemical binding]; other site
634458002096	active site
634458002097	CrcB-like protein; Region: CRCB; cl09114
634458002098	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
634458002099	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634458002100	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
634458002101	dinuclear metal binding motif [ion binding]; other site
634458002102	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
634458002103	Hint domain; Region: Hint_2; pfam13403
634458002104	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634458002105	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634458002106	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
634458002107	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
634458002108	active site
634458002109	Zn binding site [ion binding]; other site
634458002110	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458002111	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458002112	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458002113	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458002114	Coenzyme A transferase; Region: CoA_trans; smart00882
634458002115	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458002116	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458002117	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458002118	Coenzyme A transferase; Region: CoA_trans; cl17247
634458002119	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
634458002120	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
634458002121	MOFRL family; Region: MOFRL; pfam05161
634458002122	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634458002123	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634458002124	active site
634458002125	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
634458002126	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458002127	NAD(P) binding site [chemical binding]; other site
634458002128	active site
634458002129	Protein of unknown function (DUF993); Region: DUF993; pfam06187
634458002130	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
634458002131	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
634458002132	DNA interaction; other site
634458002133	Metal-binding active site; metal-binding site
634458002134	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
634458002135	Electron transfer flavoprotein domain; Region: ETF; pfam01012
634458002136	Ligand binding site [chemical binding]; other site
634458002137	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458002138	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458002139	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458002140	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
634458002141	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
634458002142	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
634458002143	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634458002144	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
634458002145	NAD(P) binding site [chemical binding]; other site
634458002146	catalytic residues [active]
634458002147	choline dehydrogenase; Validated; Region: PRK02106
634458002148	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634458002149	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
634458002150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458002151	putative substrate translocation pore; other site
634458002152	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634458002153	Hint domain; Region: Hint_2; pfam13403
634458002154	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458002155	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458002156	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458002157	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458002158	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
634458002159	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
634458002160	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
634458002161	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
634458002162	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
634458002163	tetramer interface [polypeptide binding]; other site
634458002164	TPP-binding site [chemical binding]; other site
634458002165	heterodimer interface [polypeptide binding]; other site
634458002166	phosphorylation loop region [posttranslational modification]
634458002167	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
634458002168	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
634458002169	alpha subunit interface [polypeptide binding]; other site
634458002170	TPP binding site [chemical binding]; other site
634458002171	heterodimer interface [polypeptide binding]; other site
634458002172	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634458002173	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
634458002174	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634458002175	E3 interaction surface; other site
634458002176	lipoyl attachment site [posttranslational modification]; other site
634458002177	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
634458002178	catalytic site [active]
634458002179	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634458002180	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
634458002181	putative dimer interface [polypeptide binding]; other site
634458002182	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
634458002183	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634458002184	FOG: WD40 repeat [General function prediction only]; Region: COG2319
634458002185	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
634458002186	structural tetrad; other site
634458002187	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
634458002188	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
634458002189	P-loop, Walker A motif; other site
634458002190	Base recognition motif; other site
634458002191	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
634458002192	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
634458002193	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
634458002194	putative ion selectivity filter; other site
634458002195	putative pore gating glutamate residue; other site
634458002196	putative H+/Cl- coupling transport residue; other site
634458002197	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
634458002198	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
634458002199	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
634458002200	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
634458002201	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634458002202	acyl-CoA esterase; Provisional; Region: PRK10673
634458002203	PGAP1-like protein; Region: PGAP1; pfam07819
634458002204	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634458002205	Ligand Binding Site [chemical binding]; other site
634458002206	Predicted membrane protein [Function unknown]; Region: COG1297
634458002207	putative oligopeptide transporter, OPT family; Region: TIGR00733
634458002208	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
634458002209	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
634458002210	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
634458002211	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
634458002212	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
634458002213	ATP binding site [chemical binding]; other site
634458002214	substrate interface [chemical binding]; other site
634458002215	Bacterial SH3 domain; Region: SH3_4; pfam06347
634458002216	Bacterial SH3 domain; Region: SH3_4; pfam06347
634458002217	pyruvate kinase; Provisional; Region: PRK06247
634458002218	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
634458002219	domain interfaces; other site
634458002220	active site
634458002221	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
634458002222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458002223	putative substrate translocation pore; other site
634458002224	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634458002225	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
634458002226	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
634458002227	G1 box; other site
634458002228	putative GEF interaction site [polypeptide binding]; other site
634458002229	GTP/Mg2+ binding site [chemical binding]; other site
634458002230	Switch I region; other site
634458002231	G2 box; other site
634458002232	G3 box; other site
634458002233	Switch II region; other site
634458002234	G4 box; other site
634458002235	G5 box; other site
634458002236	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
634458002237	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
634458002238	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
634458002239	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634458002240	hydroxyglutarate oxidase; Provisional; Region: PRK11728
634458002241	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
634458002242	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634458002243	isocitrate dehydrogenase; Validated; Region: PRK08299
634458002244	hypothetical protein; Provisional; Region: PRK08912
634458002245	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458002246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458002247	homodimer interface [polypeptide binding]; other site
634458002248	catalytic residue [active]
634458002249	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
634458002250	Nitrogen regulatory protein P-II; Region: P-II; smart00938
634458002251	glutamine synthetase; Provisional; Region: glnA; PRK09469
634458002252	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
634458002253	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
634458002254	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634458002255	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634458002256	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634458002257	Trp docking motif [polypeptide binding]; other site
634458002258	putative active site [active]
634458002259	Predicted transcriptional regulator [Transcription]; Region: COG2932
634458002260	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634458002261	Catalytic site [active]
634458002262	GTP-binding protein LepA; Provisional; Region: PRK05433
634458002263	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
634458002264	G1 box; other site
634458002265	putative GEF interaction site [polypeptide binding]; other site
634458002266	GTP/Mg2+ binding site [chemical binding]; other site
634458002267	Switch I region; other site
634458002268	G2 box; other site
634458002269	G3 box; other site
634458002270	Switch II region; other site
634458002271	G4 box; other site
634458002272	G5 box; other site
634458002273	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
634458002274	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
634458002275	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
634458002276	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
634458002277	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
634458002278	Methyltransferase domain; Region: Methyltransf_23; pfam13489
634458002279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458002280	S-adenosylmethionine binding site [chemical binding]; other site
634458002281	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634458002282	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634458002283	ATP binding site [chemical binding]; other site
634458002284	Mg++ binding site [ion binding]; other site
634458002285	motif III; other site
634458002286	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458002287	nucleotide binding region [chemical binding]; other site
634458002288	ATP-binding site [chemical binding]; other site
634458002289	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
634458002290	putative catalytic site [active]
634458002291	putative metal binding site [ion binding]; other site
634458002292	putative phosphate binding site [ion binding]; other site
634458002293	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
634458002294	active site clefts [active]
634458002295	zinc binding site [ion binding]; other site
634458002296	dimer interface [polypeptide binding]; other site
634458002297	LabA_like proteins; Region: LabA; cd10911
634458002298	Uncharacterized conserved protein [Function unknown]; Region: COG1432
634458002299	putative metal binding site [ion binding]; other site
634458002300	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
634458002301	catalytic center binding site [active]
634458002302	ATP binding site [chemical binding]; other site
634458002303	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
634458002304	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
634458002305	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
634458002306	Zn2+ binding site [ion binding]; other site
634458002307	Mg2+ binding site [ion binding]; other site
634458002308	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
634458002309	synthetase active site [active]
634458002310	NTP binding site [chemical binding]; other site
634458002311	metal binding site [ion binding]; metal-binding site
634458002312	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
634458002313	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
634458002314	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
634458002315	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
634458002316	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
634458002317	Catalytic site [active]
634458002318	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
634458002319	ribonuclease III; Reviewed; Region: rnc; PRK00102
634458002320	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
634458002321	dimerization interface [polypeptide binding]; other site
634458002322	active site
634458002323	metal binding site [ion binding]; metal-binding site
634458002324	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
634458002325	GTPase Era; Reviewed; Region: era; PRK00089
634458002326	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
634458002327	G1 box; other site
634458002328	GTP/Mg2+ binding site [chemical binding]; other site
634458002329	Switch I region; other site
634458002330	G2 box; other site
634458002331	Switch II region; other site
634458002332	G3 box; other site
634458002333	G4 box; other site
634458002334	G5 box; other site
634458002335	KH domain; Region: KH_2; pfam07650
634458002336	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
634458002337	putative nucleotide binding site [chemical binding]; other site
634458002338	uridine monophosphate binding site [chemical binding]; other site
634458002339	homohexameric interface [polypeptide binding]; other site
634458002340	ribosome recycling factor; Reviewed; Region: frr; PRK00083
634458002341	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
634458002342	hinge region; other site
634458002343	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
634458002344	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
634458002345	catalytic residue [active]
634458002346	putative FPP diphosphate  binding site; other site
634458002347	putative FPP binding hydrophobic cleft; other site
634458002348	dimer interface [polypeptide binding]; other site
634458002349	putative IPP diphosphate binding site; other site
634458002350	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
634458002351	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
634458002352	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
634458002353	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
634458002354	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
634458002355	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
634458002356	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
634458002357	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
634458002358	active site
634458002359	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
634458002360	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
634458002361	putative substrate binding region [chemical binding]; other site
634458002362	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634458002363	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
634458002364	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634458002365	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634458002366	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634458002367	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634458002368	Surface antigen; Region: Bac_surface_Ag; pfam01103
634458002369	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
634458002370	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
634458002371	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
634458002372	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
634458002373	trimer interface [polypeptide binding]; other site
634458002374	active site
634458002375	UDP-GlcNAc binding site [chemical binding]; other site
634458002376	lipid binding site [chemical binding]; lipid-binding site
634458002377	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
634458002378	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
634458002379	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
634458002380	active site
634458002381	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
634458002382	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
634458002383	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634458002384	dimer interface [polypeptide binding]; other site
634458002385	active site
634458002386	metal binding site [ion binding]; metal-binding site
634458002387	glutathione binding site [chemical binding]; other site
634458002388	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
634458002389	Ribonuclease P; Region: Ribonuclease_P; pfam00825
634458002390	membrane protein insertase; Provisional; Region: PRK01318
634458002391	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
634458002392	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
634458002393	G1 box; other site
634458002394	GTP/Mg2+ binding site [chemical binding]; other site
634458002395	Switch I region; other site
634458002396	G2 box; other site
634458002397	G3 box; other site
634458002398	Switch II region; other site
634458002399	G4 box; other site
634458002400	G5 box; other site
634458002401	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
634458002402	homohexameric interface [polypeptide binding]; other site
634458002403	feedback inhibition sensing region; other site
634458002404	nucleotide binding site [chemical binding]; other site
634458002405	N-acetyl-L-glutamate binding site [chemical binding]; other site
634458002406	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
634458002407	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
634458002408	trimer interface [polypeptide binding]; other site
634458002409	active site
634458002410	substrate binding site [chemical binding]; other site
634458002411	CoA binding site [chemical binding]; other site
634458002412	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
634458002413	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
634458002414	metal binding site [ion binding]; metal-binding site
634458002415	dimer interface [polypeptide binding]; other site
634458002416	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
634458002417	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
634458002418	dimerization interface 3.5A [polypeptide binding]; other site
634458002419	active site
634458002420	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
634458002421	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
634458002422	putative active site [active]
634458002423	substrate binding site [chemical binding]; other site
634458002424	putative cosubstrate binding site; other site
634458002425	catalytic site [active]
634458002426	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
634458002427	substrate binding site [chemical binding]; other site
634458002428	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
634458002429	active site
634458002430	catalytic residues [active]
634458002431	metal binding site [ion binding]; metal-binding site
634458002432	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634458002433	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
634458002434	putative dimer interface [polypeptide binding]; other site
634458002435	Protein of unknown function (DUF1150); Region: DUF1150; cl11577
634458002436	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
634458002437	30S subunit binding site; other site
634458002438	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
634458002439	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
634458002440	MOSC domain; Region: MOSC; pfam03473
634458002441	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
634458002442	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
634458002443	Walker A/P-loop; other site
634458002444	ATP binding site [chemical binding]; other site
634458002445	Q-loop/lid; other site
634458002446	ABC transporter signature motif; other site
634458002447	Walker B; other site
634458002448	D-loop; other site
634458002449	H-loop/switch region; other site
634458002450	OstA-like protein; Region: OstA; cl00844
634458002451	OstA-like protein; Region: OstA; cl00844
634458002452	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
634458002453	KpsF/GutQ family protein; Region: kpsF; TIGR00393
634458002454	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
634458002455	putative active site [active]
634458002456	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
634458002457	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
634458002458	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
634458002459	catalytic site [active]
634458002460	putative active site [active]
634458002461	putative substrate binding site [chemical binding]; other site
634458002462	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
634458002463	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
634458002464	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
634458002465	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
634458002466	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634458002467	short chain dehydrogenase; Provisional; Region: PRK07024
634458002468	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458002469	NAD(P) binding site [chemical binding]; other site
634458002470	active site
634458002471	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
634458002472	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
634458002473	catalytic site [active]
634458002474	G-X2-G-X-G-K; other site
634458002475	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
634458002476	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
634458002477	putative ribose interaction site [chemical binding]; other site
634458002478	putative ADP binding site [chemical binding]; other site
634458002479	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
634458002480	active site
634458002481	nucleotide binding site [chemical binding]; other site
634458002482	HIGH motif; other site
634458002483	KMSKS motif; other site
634458002484	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
634458002485	dimerization interface [polypeptide binding]; other site
634458002486	putative active cleft [active]
634458002487	replicative DNA helicase; Provisional; Region: PRK09165
634458002488	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
634458002489	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
634458002490	Walker A motif; other site
634458002491	ATP binding site [chemical binding]; other site
634458002492	Walker B motif; other site
634458002493	DNA binding loops [nucleotide binding]
634458002494	Nuclease-related domain; Region: NERD; pfam08378
634458002495	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
634458002496	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634458002497	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
634458002498	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
634458002499	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458002500	Walker A/P-loop; other site
634458002501	ATP binding site [chemical binding]; other site
634458002502	Q-loop/lid; other site
634458002503	ABC transporter signature motif; other site
634458002504	Walker B; other site
634458002505	D-loop; other site
634458002506	H-loop/switch region; other site
634458002507	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
634458002508	Permease; Region: Permease; pfam02405
634458002509	DNA repair protein RadA; Provisional; Region: PRK11823
634458002510	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
634458002511	Walker A motif/ATP binding site; other site
634458002512	ATP binding site [chemical binding]; other site
634458002513	Walker B motif; other site
634458002514	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
634458002515	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
634458002516	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634458002517	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
634458002518	Proline dehydrogenase; Region: Pro_dh; pfam01619
634458002519	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
634458002520	NAD(P) binding site [chemical binding]; other site
634458002521	catalytic residues [active]
634458002522	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
634458002523	Transcriptional regulators [Transcription]; Region: GntR; COG1802
634458002524	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634458002525	DNA-binding site [nucleotide binding]; DNA binding site
634458002526	FCD domain; Region: FCD; pfam07729
634458002527	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
634458002528	acetyl-CoA synthetase; Provisional; Region: PRK00174
634458002529	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
634458002530	acyl-activating enzyme (AAE) consensus motif; other site
634458002531	AMP binding site [chemical binding]; other site
634458002532	active site
634458002533	CoA binding site [chemical binding]; other site
634458002534	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
634458002535	FtsJ-like methyltransferase; Region: FtsJ; cl17430
634458002536	Protein of unknown function (DUF423); Region: DUF423; pfam04241
634458002537	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
634458002538	hypothetical protein; Validated; Region: PRK09039
634458002539	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
634458002540	FAD binding domain; Region: FAD_binding_4; pfam01565
634458002541	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
634458002542	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
634458002543	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
634458002544	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634458002545	active site
634458002546	multifunctional aminopeptidase A; Provisional; Region: PRK00913
634458002547	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
634458002548	interface (dimer of trimers) [polypeptide binding]; other site
634458002549	Substrate-binding/catalytic site; other site
634458002550	Zn-binding sites [ion binding]; other site
634458002551	DNA polymerase III subunit chi; Validated; Region: PRK05728
634458002552	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
634458002553	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
634458002554	active site
634458002555	catalytic tetrad [active]
634458002556	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
634458002557	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634458002558	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634458002559	protein binding site [polypeptide binding]; other site
634458002560	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
634458002561	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458002562	ATP binding site [chemical binding]; other site
634458002563	putative Mg++ binding site [ion binding]; other site
634458002564	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458002565	nucleotide binding region [chemical binding]; other site
634458002566	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
634458002567	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
634458002568	dimerization interface [polypeptide binding]; other site
634458002569	domain crossover interface; other site
634458002570	redox-dependent activation switch; other site
634458002571	ornithine carbamoyltransferase; Provisional; Region: PRK00779
634458002572	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
634458002573	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
634458002574	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
634458002575	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634458002576	inhibitor-cofactor binding pocket; inhibition site
634458002577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458002578	catalytic residue [active]
634458002579	RecX family; Region: RecX; pfam02631
634458002580	CHAP domain; Region: CHAP; cl17642
634458002581	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
634458002582	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
634458002583	intersubunit interface [polypeptide binding]; other site
634458002584	active site
634458002585	Zn2+ binding site [ion binding]; other site
634458002586	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
634458002587	Cupin domain; Region: Cupin_2; cl17218
634458002588	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
634458002589	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
634458002590	motif II; other site
634458002591	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
634458002592	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
634458002593	active site
634458002594	Riboflavin kinase; Region: Flavokinase; smart00904
634458002595	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
634458002596	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634458002597	active site
634458002598	HIGH motif; other site
634458002599	nucleotide binding site [chemical binding]; other site
634458002600	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
634458002601	active site
634458002602	KMSKS motif; other site
634458002603	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
634458002604	tRNA binding surface [nucleotide binding]; other site
634458002605	anticodon binding site; other site
634458002606	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
634458002607	lipoprotein signal peptidase; Provisional; Region: PRK14770
634458002608	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
634458002609	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
634458002610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458002611	ATP binding site [chemical binding]; other site
634458002612	Mg2+ binding site [ion binding]; other site
634458002613	G-X-G motif; other site
634458002614	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
634458002615	ATP binding site [chemical binding]; other site
634458002616	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
634458002617	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
634458002618	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634458002619	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
634458002620	EamA-like transporter family; Region: EamA; pfam00892
634458002621	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
634458002622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458002623	Mg2+ binding site [ion binding]; other site
634458002624	G-X-G motif; other site
634458002625	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
634458002626	anchoring element; other site
634458002627	dimer interface [polypeptide binding]; other site
634458002628	ATP binding site [chemical binding]; other site
634458002629	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
634458002630	active site
634458002631	putative metal-binding site [ion binding]; other site
634458002632	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
634458002633	Rrf2 family protein; Region: rrf2_super; TIGR00738
634458002634	Transcriptional regulator; Region: Rrf2; pfam02082
634458002635	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
634458002636	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
634458002637	dimer interface [polypeptide binding]; other site
634458002638	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458002639	catalytic residue [active]
634458002640	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
634458002641	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634458002642	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634458002643	ligand binding site [chemical binding]; other site
634458002644	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
634458002645	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
634458002646	C-terminal peptidase (prc); Region: prc; TIGR00225
634458002647	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
634458002648	protein binding site [polypeptide binding]; other site
634458002649	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
634458002650	Catalytic dyad [active]
634458002651	Exoribonuclease R [Transcription]; Region: VacB; COG0557
634458002652	RNB domain; Region: RNB; pfam00773
634458002653	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
634458002654	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
634458002655	active site
634458002656	interdomain interaction site; other site
634458002657	putative metal-binding site [ion binding]; other site
634458002658	nucleotide binding site [chemical binding]; other site
634458002659	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
634458002660	domain I; other site
634458002661	DNA binding groove [nucleotide binding]
634458002662	phosphate binding site [ion binding]; other site
634458002663	domain II; other site
634458002664	domain III; other site
634458002665	nucleotide binding site [chemical binding]; other site
634458002666	catalytic site [active]
634458002667	domain IV; other site
634458002668	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
634458002669	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634458002670	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634458002671	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
634458002672	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
634458002673	DNA protecting protein DprA; Region: dprA; TIGR00732
634458002674	DDE superfamily endonuclease; Region: DDE_5; pfam13546
634458002675	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458002676	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458002677	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
634458002678	DNA protecting protein DprA; Region: dprA; TIGR00732
634458002679	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
634458002680	dihydroorotase; Validated; Region: pyrC; PRK09357
634458002681	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634458002682	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
634458002683	active site
634458002684	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
634458002685	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
634458002686	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
634458002687	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
634458002688	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634458002689	active site
634458002690	HIGH motif; other site
634458002691	nucleotide binding site [chemical binding]; other site
634458002692	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
634458002693	active site
634458002694	KMSKS motif; other site
634458002695	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
634458002696	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
634458002697	Competence protein; Region: Competence; pfam03772
634458002698	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
634458002699	Predicted ATPase [General function prediction only]; Region: COG1485
634458002700	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
634458002701	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
634458002702	TPP-binding site [chemical binding]; other site
634458002703	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
634458002704	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
634458002705	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634458002706	E3 interaction surface; other site
634458002707	lipoyl attachment site [posttranslational modification]; other site
634458002708	e3 binding domain; Region: E3_binding; pfam02817
634458002709	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
634458002710	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634458002711	E3 interaction surface; other site
634458002712	lipoyl attachment site [posttranslational modification]; other site
634458002713	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
634458002714	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634458002715	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634458002716	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
634458002717	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
634458002718	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
634458002719	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
634458002720	homotetramer interface [polypeptide binding]; other site
634458002721	ligand binding site [chemical binding]; other site
634458002722	catalytic site [active]
634458002723	NAD binding site [chemical binding]; other site
634458002724	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
634458002725	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634458002726	putative acyl-acceptor binding pocket; other site
634458002727	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
634458002728	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
634458002729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634458002730	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
634458002731	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
634458002732	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
634458002733	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
634458002734	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
634458002735	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
634458002736	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
634458002737	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
634458002738	motif 1; other site
634458002739	active site
634458002740	motif 2; other site
634458002741	motif 3; other site
634458002742	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
634458002743	TraB family; Region: TraB; cl12050
634458002744	Predicted membrane protein [Function unknown]; Region: COG2246
634458002745	GtrA-like protein; Region: GtrA; pfam04138
634458002746	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
634458002747	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634458002748	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634458002749	ligand binding site [chemical binding]; other site
634458002750	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
634458002751	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
634458002752	ADP binding site [chemical binding]; other site
634458002753	magnesium binding site [ion binding]; other site
634458002754	putative shikimate binding site; other site
634458002755	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
634458002756	active site
634458002757	dimer interface [polypeptide binding]; other site
634458002758	metal binding site [ion binding]; metal-binding site
634458002759	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
634458002760	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458002761	active site
634458002762	DNA binding site [nucleotide binding]
634458002763	Int/Topo IB signature motif; other site
634458002764	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
634458002765	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
634458002766	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
634458002767	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
634458002768	putative MPT binding site; other site
634458002769	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
634458002770	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634458002771	active site
634458002772	nucleotide binding site [chemical binding]; other site
634458002773	HIGH motif; other site
634458002774	KMSKS motif; other site
634458002775	Predicted integral membrane protein [Function unknown]; Region: COG0392
634458002776	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
634458002777	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
634458002778	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
634458002779	UGMP family protein; Validated; Region: PRK09604
634458002780	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
634458002781	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
634458002782	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
634458002783	domain interfaces; other site
634458002784	active site
634458002785	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
634458002786	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
634458002787	active site
634458002788	preprotein translocase subunit SecB; Validated; Region: PRK05751
634458002789	SecA binding site; other site
634458002790	Preprotein binding site; other site
634458002791	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634458002792	catalytic core [active]
634458002793	Tim44-like domain; Region: Tim44; pfam04280
634458002794	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
634458002795	DNA methylase; Region: N6_N4_Mtase; pfam01555
634458002796	Haem-binding domain; Region: Haem_bd; pfam14376
634458002797	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
634458002798	Smr domain; Region: Smr; pfam01713
634458002799	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
634458002800	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
634458002801	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634458002802	Qi binding site; other site
634458002803	intrachain domain interface; other site
634458002804	interchain domain interface [polypeptide binding]; other site
634458002805	heme bH binding site [chemical binding]; other site
634458002806	heme bL binding site [chemical binding]; other site
634458002807	Qo binding site; other site
634458002808	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
634458002809	intrachain domain interface; other site
634458002810	interchain domain interface [polypeptide binding]; other site
634458002811	Qi binding site; other site
634458002812	Qo binding site; other site
634458002813	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
634458002814	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
634458002815	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
634458002816	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
634458002817	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
634458002818	FMN binding site [chemical binding]; other site
634458002819	dimer interface [polypeptide binding]; other site
634458002820	ornithine cyclodeaminase; Validated; Region: PRK07340
634458002821	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
634458002822	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
634458002823	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
634458002824	NAD(P) binding site [chemical binding]; other site
634458002825	catalytic residues [active]
634458002826	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458002827	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458002828	WHG domain; Region: WHG; pfam13305
634458002829	Transposase; Region: HTH_Tnp_1; pfam01527
634458002830	HTH-like domain; Region: HTH_21; pfam13276
634458002831	Integrase core domain; Region: rve; pfam00665
634458002832	Integrase core domain; Region: rve_3; pfam13683
634458002833	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458002834	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634458002835	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458002836	catalytic residues [active]
634458002837	catalytic nucleophile [active]
634458002838	Presynaptic Site I dimer interface [polypeptide binding]; other site
634458002839	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634458002840	Synaptic Flat tetramer interface [polypeptide binding]; other site
634458002841	Synaptic Site I dimer interface [polypeptide binding]; other site
634458002842	DNA binding site [nucleotide binding]
634458002843	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458002844	DNA-binding interface [nucleotide binding]; DNA binding site
634458002845	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458002846	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458002847	active site
634458002848	DNA binding site [nucleotide binding]
634458002849	Int/Topo IB signature motif; other site
634458002850	integrase; Provisional; Region: PRK09692
634458002851	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
634458002852	active site
634458002853	Int/Topo IB signature motif; other site
634458002854	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889
634458002855	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
634458002856	HicB family; Region: HicB; pfam05534
634458002857	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
634458002858	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
634458002859	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
634458002860	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458002861	Walker A/P-loop; other site
634458002862	ATP binding site [chemical binding]; other site
634458002863	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
634458002864	synthetase active site [active]
634458002865	NTP binding site [chemical binding]; other site
634458002866	metal binding site [ion binding]; metal-binding site
634458002867	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634458002868	Transposase; Region: HTH_Tnp_1; pfam01527
634458002869	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634458002870	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634458002871	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634458002872	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634458002873	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634458002874	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634458002875	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634458002876	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634458002877	HTH-like domain; Region: HTH_21; pfam13276
634458002878	Integrase core domain; Region: rve; pfam00665
634458002879	Integrase core domain; Region: rve_3; pfam13683
634458002880	Transposase; Region: HTH_Tnp_1; pfam01527
634458002881	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634458002882	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458002883	non-specific DNA binding site [nucleotide binding]; other site
634458002884	salt bridge; other site
634458002885	sequence-specific DNA binding site [nucleotide binding]; other site
634458002886	hypothetical protein; Validated; Region: PRK07078
634458002887	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
634458002888	active site
634458002889	metal binding site [ion binding]; metal-binding site
634458002890	interdomain interaction site; other site
634458002891	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
634458002892	Domain of unknown function (DUF927); Region: DUF927; pfam06048
634458002893	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
634458002894	active site
634458002895	oligomerization interface [polypeptide binding]; other site
634458002896	metal binding site [ion binding]; metal-binding site
634458002897	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
634458002898	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
634458002899	active site
634458002900	FMN binding site [chemical binding]; other site
634458002901	substrate binding site [chemical binding]; other site
634458002902	homotetramer interface [polypeptide binding]; other site
634458002903	catalytic residue [active]
634458002904	Helix-turn-helix domain; Region: HTH_20; pfam12840
634458002905	dimerization interface [polypeptide binding]; other site
634458002906	putative DNA binding site [nucleotide binding]; other site
634458002907	putative Zn2+ binding site [ion binding]; other site
634458002908	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634458002909	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
634458002910	putative NAD(P) binding site [chemical binding]; other site
634458002911	putative substrate binding site [chemical binding]; other site
634458002912	catalytic Zn binding site [ion binding]; other site
634458002913	structural Zn binding site [ion binding]; other site
634458002914	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
634458002915	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
634458002916	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
634458002917	NAD binding site [chemical binding]; other site
634458002918	homodimer interface [polypeptide binding]; other site
634458002919	active site
634458002920	substrate binding site [chemical binding]; other site
634458002921	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
634458002922	diaminopimelate decarboxylase; Region: lysA; TIGR01048
634458002923	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
634458002924	active site
634458002925	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634458002926	substrate binding site [chemical binding]; other site
634458002927	catalytic residues [active]
634458002928	dimer interface [polypeptide binding]; other site
634458002929	argininosuccinate lyase; Provisional; Region: PRK00855
634458002930	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
634458002931	active sites [active]
634458002932	tetramer interface [polypeptide binding]; other site
634458002933	N-formylglutamate amidohydrolase; Region: FGase; cl01522
634458002934	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
634458002935	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
634458002936	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
634458002937	shikimate binding site; other site
634458002938	NAD(P) binding site [chemical binding]; other site
634458002939	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
634458002940	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
634458002941	CoA-binding site [chemical binding]; other site
634458002942	ATP-binding [chemical binding]; other site
634458002943	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
634458002944	active site
634458002945	catalytic site [active]
634458002946	substrate binding site [chemical binding]; other site
634458002947	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458002948	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
634458002949	putative ADP-binding pocket [chemical binding]; other site
634458002950	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
634458002951	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
634458002952	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
634458002953	substrate binding site [chemical binding]; other site
634458002954	hexamer interface [polypeptide binding]; other site
634458002955	metal binding site [ion binding]; metal-binding site
634458002956	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
634458002957	putative RNA binding site [nucleotide binding]; other site
634458002958	16S rRNA methyltransferase B; Provisional; Region: PRK10901
634458002959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458002960	S-adenosylmethionine binding site [chemical binding]; other site
634458002961	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
634458002962	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
634458002963	active site
634458002964	substrate binding site [chemical binding]; other site
634458002965	cosubstrate binding site; other site
634458002966	catalytic site [active]
634458002967	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
634458002968	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
634458002969	dimerization interface [polypeptide binding]; other site
634458002970	putative ATP binding site [chemical binding]; other site
634458002971	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
634458002972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
634458002973	polyphosphate kinase; Provisional; Region: PRK05443
634458002974	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
634458002975	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
634458002976	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
634458002977	putative domain interface [polypeptide binding]; other site
634458002978	putative active site [active]
634458002979	catalytic site [active]
634458002980	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
634458002981	putative domain interface [polypeptide binding]; other site
634458002982	putative active site [active]
634458002983	catalytic site [active]
634458002984	exopolyphosphatase; Region: exo_poly_only; TIGR03706
634458002985	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
634458002986	Cache domain; Region: Cache_1; pfam02743
634458002987	cyclase homology domain; Region: CHD; cd07302
634458002988	nucleotidyl binding site; other site
634458002989	metal binding site [ion binding]; metal-binding site
634458002990	dimer interface [polypeptide binding]; other site
634458002991	Permease; Region: Permease; pfam02405
634458002992	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
634458002993	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458002994	Q-loop/lid; other site
634458002995	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
634458002996	mce related protein; Region: MCE; pfam02470
634458002997	sugar binding site [chemical binding]; other site
634458002998	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
634458002999	Inward rectifier potassium channel; Region: IRK; pfam01007
634458003000	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634458003001	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634458003002	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634458003003	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634458003004	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
634458003005	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
634458003006	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
634458003007	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
634458003008	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
634458003009	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
634458003010	catalytic residues [active]
634458003011	central insert; other site
634458003012	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
634458003013	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
634458003014	heme exporter protein CcmC; Region: ccmC; TIGR01191
634458003015	YciI-like protein; Reviewed; Region: PRK12863
634458003016	EVE domain; Region: EVE; pfam01878
634458003017	Putative phosphatase (DUF442); Region: DUF442; cl17385
634458003018	EcsC protein family; Region: EcsC; pfam12787
634458003019	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
634458003020	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
634458003021	dimerization interface [polypeptide binding]; other site
634458003022	ligand binding site [chemical binding]; other site
634458003023	NADP binding site [chemical binding]; other site
634458003024	catalytic site [active]
634458003025	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
634458003026	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
634458003027	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
634458003028	Protein of unknown function; Region: DUF3971; pfam13116
634458003029	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634458003030	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
634458003031	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634458003032	metal binding triad; other site
634458003033	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634458003034	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634458003035	metal binding triad; other site
634458003036	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634458003037	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
634458003038	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
634458003039	catalytic triad [active]
634458003040	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
634458003041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458003042	putative substrate translocation pore; other site
634458003043	RmuC family; Region: RmuC; pfam02646
634458003044	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634458003045	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458003046	active site
634458003047	phosphorylation site [posttranslational modification]
634458003048	intermolecular recognition site; other site
634458003049	dimerization interface [polypeptide binding]; other site
634458003050	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458003051	DNA binding site [nucleotide binding]
634458003052	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634458003053	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634458003054	dimerization interface [polypeptide binding]; other site
634458003055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458003056	ATP binding site [chemical binding]; other site
634458003057	Mg2+ binding site [ion binding]; other site
634458003058	G-X-G motif; other site
634458003059	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634458003060	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634458003061	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458003062	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458003063	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634458003064	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
634458003065	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
634458003066	23S rRNA interface [nucleotide binding]; other site
634458003067	L7/L12 interface [polypeptide binding]; other site
634458003068	putative thiostrepton binding site; other site
634458003069	L25 interface [polypeptide binding]; other site
634458003070	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
634458003071	mRNA/rRNA interface [nucleotide binding]; other site
634458003072	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
634458003073	23S rRNA interface [nucleotide binding]; other site
634458003074	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
634458003075	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
634458003076	L11 interface [polypeptide binding]; other site
634458003077	putative EF-Tu interaction site [polypeptide binding]; other site
634458003078	putative EF-G interaction site [polypeptide binding]; other site
634458003079	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
634458003080	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
634458003081	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
634458003082	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
634458003083	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
634458003084	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
634458003085	RPB1 interaction site [polypeptide binding]; other site
634458003086	RPB11 interaction site [polypeptide binding]; other site
634458003087	RPB10 interaction site [polypeptide binding]; other site
634458003088	RPB3 interaction site [polypeptide binding]; other site
634458003089	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
634458003090	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
634458003091	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
634458003092	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
634458003093	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
634458003094	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
634458003095	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
634458003096	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
634458003097	DNA binding site [nucleotide binding]
634458003098	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
634458003099	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
634458003100	S17 interaction site [polypeptide binding]; other site
634458003101	S8 interaction site; other site
634458003102	16S rRNA interaction site [nucleotide binding]; other site
634458003103	streptomycin interaction site [chemical binding]; other site
634458003104	23S rRNA interaction site [nucleotide binding]; other site
634458003105	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
634458003106	30S ribosomal protein S7; Validated; Region: PRK05302
634458003107	elongation factor Tu; Reviewed; Region: PRK00049
634458003108	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
634458003109	G1 box; other site
634458003110	GEF interaction site [polypeptide binding]; other site
634458003111	GTP/Mg2+ binding site [chemical binding]; other site
634458003112	Switch I region; other site
634458003113	G2 box; other site
634458003114	G3 box; other site
634458003115	Switch II region; other site
634458003116	G4 box; other site
634458003117	G5 box; other site
634458003118	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
634458003119	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
634458003120	Antibiotic Binding Site [chemical binding]; other site
634458003121	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
634458003122	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
634458003123	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
634458003124	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
634458003125	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
634458003126	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
634458003127	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
634458003128	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
634458003129	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
634458003130	putative translocon binding site; other site
634458003131	protein-rRNA interface [nucleotide binding]; other site
634458003132	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
634458003133	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
634458003134	G-X-X-G motif; other site
634458003135	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
634458003136	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
634458003137	23S rRNA interface [nucleotide binding]; other site
634458003138	5S rRNA interface [nucleotide binding]; other site
634458003139	putative antibiotic binding site [chemical binding]; other site
634458003140	L25 interface [polypeptide binding]; other site
634458003141	L27 interface [polypeptide binding]; other site
634458003142	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
634458003143	23S rRNA interface [nucleotide binding]; other site
634458003144	putative translocon interaction site; other site
634458003145	signal recognition particle (SRP54) interaction site; other site
634458003146	L23 interface [polypeptide binding]; other site
634458003147	trigger factor interaction site; other site
634458003148	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
634458003149	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
634458003150	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
634458003151	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
634458003152	RNA binding site [nucleotide binding]; other site
634458003153	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
634458003154	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
634458003155	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
634458003156	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
634458003157	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
634458003158	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
634458003159	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
634458003160	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
634458003161	5S rRNA interface [nucleotide binding]; other site
634458003162	23S rRNA interface [nucleotide binding]; other site
634458003163	L5 interface [polypeptide binding]; other site
634458003164	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
634458003165	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
634458003166	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
634458003167	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
634458003168	23S rRNA binding site [nucleotide binding]; other site
634458003169	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
634458003170	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
634458003171	SecY translocase; Region: SecY; pfam00344
634458003172	adenylate kinase; Reviewed; Region: adk; PRK00279
634458003173	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
634458003174	AMP-binding site [chemical binding]; other site
634458003175	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
634458003176	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
634458003177	30S ribosomal protein S13; Region: bact_S13; TIGR03631
634458003178	30S ribosomal protein S11; Validated; Region: PRK05309
634458003179	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
634458003180	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
634458003181	alphaNTD - beta interaction site [polypeptide binding]; other site
634458003182	alphaNTD homodimer interface [polypeptide binding]; other site
634458003183	alphaNTD - beta' interaction site [polypeptide binding]; other site
634458003184	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
634458003185	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
634458003186	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
634458003187	NMT1-like family; Region: NMT1_2; pfam13379
634458003188	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634458003189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458003190	dimer interface [polypeptide binding]; other site
634458003191	conserved gate region; other site
634458003192	putative PBP binding loops; other site
634458003193	ABC-ATPase subunit interface; other site
634458003194	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634458003195	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634458003196	Walker A/P-loop; other site
634458003197	ATP binding site [chemical binding]; other site
634458003198	Q-loop/lid; other site
634458003199	ABC transporter signature motif; other site
634458003200	Walker B; other site
634458003201	D-loop; other site
634458003202	H-loop/switch region; other site
634458003203	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634458003204	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634458003205	Protein export membrane protein; Region: SecD_SecF; cl14618
634458003206	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
634458003207	Protein export membrane protein; Region: SecD_SecF; cl14618
634458003208	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
634458003209	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458003210	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458003211	putative transporter; Provisional; Region: PRK10504
634458003212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458003213	putative substrate translocation pore; other site
634458003214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458003215	CsbD-like; Region: CsbD; pfam05532
634458003216	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
634458003217	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
634458003218	RNA/DNA hybrid binding site [nucleotide binding]; other site
634458003219	active site
634458003220	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
634458003221	DNA methylase; Region: N6_N4_Mtase; pfam01555
634458003222	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
634458003223	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634458003224	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
634458003225	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
634458003226	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
634458003227	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
634458003228	Protein of unknown function DUF58; Region: DUF58; pfam01882
634458003229	MoxR-like ATPases [General function prediction only]; Region: COG0714
634458003230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
634458003231	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
634458003232	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
634458003233	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
634458003234	active site
634458003235	NTP binding site [chemical binding]; other site
634458003236	metal binding triad [ion binding]; metal-binding site
634458003237	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
634458003238	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634458003239	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634458003240	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458003241	Walker A/P-loop; other site
634458003242	ATP binding site [chemical binding]; other site
634458003243	Q-loop/lid; other site
634458003244	ABC transporter signature motif; other site
634458003245	Walker B; other site
634458003246	D-loop; other site
634458003247	H-loop/switch region; other site
634458003248	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634458003249	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634458003250	E3 interaction surface; other site
634458003251	lipoyl attachment site [posttranslational modification]; other site
634458003252	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458003253	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634458003254	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458003255	putative substrate translocation pore; other site
634458003256	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
634458003257	putative active site [active]
634458003258	Ap4A binding site [chemical binding]; other site
634458003259	nudix motif; other site
634458003260	putative metal binding site [ion binding]; other site
634458003261	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
634458003262	NodB motif; other site
634458003263	putative active site [active]
634458003264	putative catalytic site [active]
634458003265	Zn binding site [ion binding]; other site
634458003266	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
634458003267	C-terminal peptidase (prc); Region: prc; TIGR00225
634458003268	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
634458003269	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
634458003270	Catalytic dyad [active]
634458003271	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
634458003272	Peptidase family M23; Region: Peptidase_M23; pfam01551
634458003273	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
634458003274	phosphoglyceromutase; Provisional; Region: PRK05434
634458003275	threonine dehydratase; Provisional; Region: PRK07334
634458003276	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
634458003277	tetramer interface [polypeptide binding]; other site
634458003278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458003279	catalytic residue [active]
634458003280	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
634458003281	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
634458003282	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
634458003283	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
634458003284	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
634458003285	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634458003286	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
634458003287	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
634458003288	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634458003289	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634458003290	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
634458003291	IMP binding site; other site
634458003292	dimer interface [polypeptide binding]; other site
634458003293	partial ornithine binding site; other site
634458003294	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
634458003295	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
634458003296	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
634458003297	catalytic site [active]
634458003298	subunit interface [polypeptide binding]; other site
634458003299	Yqey-like protein; Region: YqeY; pfam09424
634458003300	DNA primase; Validated; Region: dnaG; PRK05667
634458003301	CHC2 zinc finger; Region: zf-CHC2; pfam01807
634458003302	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
634458003303	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
634458003304	active site
634458003305	metal binding site [ion binding]; metal-binding site
634458003306	interdomain interaction site; other site
634458003307	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
634458003308	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
634458003309	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
634458003310	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
634458003311	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634458003312	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
634458003313	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634458003314	DNA binding residues [nucleotide binding]
634458003315	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
634458003316	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
634458003317	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
634458003318	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
634458003319	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
634458003320	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
634458003321	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
634458003322	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634458003323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458003324	S-adenosylmethionine binding site [chemical binding]; other site
634458003325	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
634458003326	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
634458003327	SurA N-terminal domain; Region: SurA_N; pfam09312
634458003328	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
634458003329	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
634458003330	OstA-like protein; Region: OstA; cl00844
634458003331	Organic solvent tolerance protein; Region: OstA_C; pfam04453
634458003332	Predicted permeases [General function prediction only]; Region: COG0795
634458003333	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634458003334	Predicted permeases [General function prediction only]; Region: COG0795
634458003335	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634458003336	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
634458003337	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634458003338	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458003339	Walker A/P-loop; other site
634458003340	ATP binding site [chemical binding]; other site
634458003341	Q-loop/lid; other site
634458003342	ABC transporter signature motif; other site
634458003343	Walker B; other site
634458003344	D-loop; other site
634458003345	H-loop/switch region; other site
634458003346	Transcriptional regulators [Transcription]; Region: GntR; COG1802
634458003347	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634458003348	DNA-binding site [nucleotide binding]; DNA binding site
634458003349	FCD domain; Region: FCD; pfam07729
634458003350	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
634458003351	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
634458003352	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
634458003353	Switch I; other site
634458003354	Switch II; other site
634458003355	septum formation inhibitor; Reviewed; Region: minC; PRK05177
634458003356	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
634458003357	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
634458003358	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634458003359	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
634458003360	C-terminal domain interface [polypeptide binding]; other site
634458003361	GSH binding site (G-site) [chemical binding]; other site
634458003362	dimer interface [polypeptide binding]; other site
634458003363	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
634458003364	N-terminal domain interface [polypeptide binding]; other site
634458003365	dimer interface [polypeptide binding]; other site
634458003366	substrate binding pocket (H-site) [chemical binding]; other site
634458003367	Predicted flavoproteins [General function prediction only]; Region: COG2081
634458003368	Predicted methyltransferases [General function prediction only]; Region: COG0313
634458003369	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
634458003370	putative SAM binding site [chemical binding]; other site
634458003371	putative homodimer interface [polypeptide binding]; other site
634458003372	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
634458003373	putative ligand binding site [chemical binding]; other site
634458003374	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634458003375	TPR motif; other site
634458003376	TPR repeat; Region: TPR_11; pfam13414
634458003377	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634458003378	TPR motif; other site
634458003379	binding surface
634458003380	TPR repeat; Region: TPR_11; pfam13414
634458003381	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
634458003382	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
634458003383	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
634458003384	S-formylglutathione hydrolase; Region: PLN02442
634458003385	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
634458003386	putative active site [active]
634458003387	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
634458003388	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
634458003389	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
634458003390	Walker A/P-loop; other site
634458003391	ATP binding site [chemical binding]; other site
634458003392	Q-loop/lid; other site
634458003393	ABC transporter signature motif; other site
634458003394	Walker B; other site
634458003395	D-loop; other site
634458003396	H-loop/switch region; other site
634458003397	zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717
634458003398	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458003399	active site
634458003400	phosphorylation site [posttranslational modification]
634458003401	intermolecular recognition site; other site
634458003402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458003403	active site
634458003404	phosphorylation site [posttranslational modification]
634458003405	intermolecular recognition site; other site
634458003406	dimerization interface [polypeptide binding]; other site
634458003407	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
634458003408	dimer interface [polypeptide binding]; other site
634458003409	phosphorylation site [posttranslational modification]
634458003410	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458003411	ATP binding site [chemical binding]; other site
634458003412	Mg2+ binding site [ion binding]; other site
634458003413	G-X-G motif; other site
634458003414	Response regulator receiver domain; Region: Response_reg; pfam00072
634458003415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458003416	active site
634458003417	phosphorylation site [posttranslational modification]
634458003418	intermolecular recognition site; other site
634458003419	dimerization interface [polypeptide binding]; other site
634458003420	PAS fold; Region: PAS_4; pfam08448
634458003421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458003422	dimer interface [polypeptide binding]; other site
634458003423	phosphorylation site [posttranslational modification]
634458003424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458003425	ATP binding site [chemical binding]; other site
634458003426	Mg2+ binding site [ion binding]; other site
634458003427	G-X-G motif; other site
634458003428	Response regulator receiver domain; Region: Response_reg; pfam00072
634458003429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458003430	active site
634458003431	phosphorylation site [posttranslational modification]
634458003432	intermolecular recognition site; other site
634458003433	dimerization interface [polypeptide binding]; other site
634458003434	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
634458003435	active site
634458003436	HslU subunit interaction site [polypeptide binding]; other site
634458003437	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
634458003438	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458003439	Walker A motif; other site
634458003440	ATP binding site [chemical binding]; other site
634458003441	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
634458003442	Walker B motif; other site
634458003443	arginine finger; other site
634458003444	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
634458003445	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
634458003446	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
634458003447	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634458003448	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634458003449	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634458003450	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
634458003451	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634458003452	catalytic loop [active]
634458003453	iron binding site [ion binding]; other site
634458003454	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634458003455	Cytochrome c; Region: Cytochrom_C; pfam00034
634458003456	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634458003457	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634458003458	Cytochrome c; Region: Cytochrom_C; pfam00034
634458003459	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
634458003460	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
634458003461	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
634458003462	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
634458003463	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
634458003464	23S rRNA binding site [nucleotide binding]; other site
634458003465	L21 binding site [polypeptide binding]; other site
634458003466	L13 binding site [polypeptide binding]; other site
634458003467	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
634458003468	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
634458003469	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
634458003470	dimer interface [polypeptide binding]; other site
634458003471	motif 1; other site
634458003472	active site
634458003473	motif 2; other site
634458003474	motif 3; other site
634458003475	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
634458003476	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
634458003477	putative tRNA-binding site [nucleotide binding]; other site
634458003478	B3/4 domain; Region: B3_4; pfam03483
634458003479	tRNA synthetase B5 domain; Region: B5; smart00874
634458003480	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
634458003481	motif 1; other site
634458003482	dimer interface [polypeptide binding]; other site
634458003483	motif 3; other site
634458003484	motif 2; other site
634458003485	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
634458003486	PBP superfamily domain; Region: PBP_like_2; cl17296
634458003487	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
634458003488	peptide binding site [polypeptide binding]; other site
634458003489	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
634458003490	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634458003491	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
634458003492	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
634458003493	ligand binding site [chemical binding]; other site
634458003494	flexible hinge region; other site
634458003495	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
634458003496	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
634458003497	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
634458003498	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634458003499	RNA binding surface [nucleotide binding]; other site
634458003500	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
634458003501	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
634458003502	G1 box; other site
634458003503	putative GEF interaction site [polypeptide binding]; other site
634458003504	GTP/Mg2+ binding site [chemical binding]; other site
634458003505	Switch I region; other site
634458003506	G2 box; other site
634458003507	G3 box; other site
634458003508	Switch II region; other site
634458003509	G4 box; other site
634458003510	G5 box; other site
634458003511	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
634458003512	hypothetical protein; Provisional; Region: PRK08999
634458003513	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
634458003514	tartrate dehydrogenase; Region: TTC; TIGR02089
634458003515	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
634458003516	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
634458003517	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
634458003518	active site
634458003519	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
634458003520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458003521	S-adenosylmethionine binding site [chemical binding]; other site
634458003522	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
634458003523	Part of AAA domain; Region: AAA_19; pfam13245
634458003524	Family description; Region: UvrD_C_2; pfam13538
634458003525	DNA repair protein radc; Region: radc; TIGR00608
634458003526	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
634458003527	DNA repair protein radc; Region: radc; TIGR00608
634458003528	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
634458003529	MPN+ (JAMM) motif; other site
634458003530	Zinc-binding site [ion binding]; other site
634458003531	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
634458003532	ATP-grasp domain; Region: ATP-grasp; pfam02222
634458003533	AIR carboxylase; Region: AIRC; pfam00731
634458003534	Protein of unknown function (DUF465); Region: DUF465; cl01070
634458003535	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
634458003536	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
634458003537	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
634458003538	putative dimer interface [polypeptide binding]; other site
634458003539	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
634458003540	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
634458003541	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
634458003542	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
634458003543	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
634458003544	Protein export membrane protein; Region: SecD_SecF; pfam02355
634458003545	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
634458003546	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
634458003547	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
634458003548	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
634458003549	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
634458003550	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
634458003551	Class I ribonucleotide reductase; Region: RNR_I; cd01679
634458003552	active site
634458003553	dimer interface [polypeptide binding]; other site
634458003554	catalytic residues [active]
634458003555	effector binding site; other site
634458003556	R2 peptide binding site; other site
634458003557	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
634458003558	dimer interface [polypeptide binding]; other site
634458003559	putative radical transfer pathway; other site
634458003560	diiron center [ion binding]; other site
634458003561	tyrosyl radical; other site
634458003562	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
634458003563	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
634458003564	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
634458003565	substrate binding pocket [chemical binding]; other site
634458003566	chain length determination region; other site
634458003567	substrate-Mg2+ binding site; other site
634458003568	catalytic residues [active]
634458003569	aspartate-rich region 1; other site
634458003570	active site lid residues [active]
634458003571	aspartate-rich region 2; other site
634458003572	glutamate racemase; Provisional; Region: PRK00865
634458003573	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634458003574	active site
634458003575	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
634458003576	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
634458003577	dimer interface [polypeptide binding]; other site
634458003578	active site
634458003579	citrylCoA binding site [chemical binding]; other site
634458003580	NADH binding [chemical binding]; other site
634458003581	cationic pore residues; other site
634458003582	oxalacetate/citrate binding site [chemical binding]; other site
634458003583	coenzyme A binding site [chemical binding]; other site
634458003584	catalytic triad [active]
634458003585	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634458003586	catalytic core [active]
634458003587	chorismate mutase; Provisional; Region: PRK09239
634458003588	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
634458003589	active site
634458003590	metal binding site [ion binding]; metal-binding site
634458003591	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
634458003592	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
634458003593	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
634458003594	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
634458003595	AAA domain; Region: AAA_23; pfam13476
634458003596	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
634458003597	Walker A/P-loop; other site
634458003598	ATP binding site [chemical binding]; other site
634458003599	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
634458003600	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
634458003601	ABC transporter signature motif; other site
634458003602	Walker B; other site
634458003603	D-loop; other site
634458003604	H-loop/switch region; other site
634458003605	Thioredoxin; Region: Thioredoxin_4; pfam13462
634458003606	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
634458003607	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
634458003608	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
634458003609	Transporter associated domain; Region: CorC_HlyC; smart01091
634458003610	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
634458003611	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
634458003612	PhoH-like protein; Region: PhoH; pfam02562
634458003613	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
634458003614	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
634458003615	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458003616	FeS/SAM binding site; other site
634458003617	TRAM domain; Region: TRAM; cl01282
634458003618	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
634458003619	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634458003620	putative acyl-acceptor binding pocket; other site
634458003621	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
634458003622	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
634458003623	Surface antigen; Region: Bac_surface_Ag; pfam01103
634458003624	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
634458003625	Family of unknown function (DUF490); Region: DUF490; pfam04357
634458003626	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
634458003627	putative catalytic site [active]
634458003628	putative phosphate binding site [ion binding]; other site
634458003629	active site
634458003630	metal binding site A [ion binding]; metal-binding site
634458003631	DNA binding site [nucleotide binding]
634458003632	putative AP binding site [nucleotide binding]; other site
634458003633	putative metal binding site B [ion binding]; other site
634458003634	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
634458003635	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
634458003636	active site
634458003637	dimer interface [polypeptide binding]; other site
634458003638	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
634458003639	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
634458003640	GIY-YIG motif/motif A; other site
634458003641	active site
634458003642	catalytic site [active]
634458003643	putative DNA binding site [nucleotide binding]; other site
634458003644	metal binding site [ion binding]; metal-binding site
634458003645	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
634458003646	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
634458003647	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
634458003648	MoaE interaction surface [polypeptide binding]; other site
634458003649	MoeB interaction surface [polypeptide binding]; other site
634458003650	thiocarboxylated glycine; other site
634458003651	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
634458003652	MoaE homodimer interface [polypeptide binding]; other site
634458003653	MoaD interaction [polypeptide binding]; other site
634458003654	active site residues [active]
634458003655	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
634458003656	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634458003657	inhibitor-cofactor binding pocket; inhibition site
634458003658	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458003659	catalytic residue [active]
634458003660	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
634458003661	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
634458003662	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634458003663	catalytic residue [active]
634458003664	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634458003665	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
634458003666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458003667	S-adenosylmethionine binding site [chemical binding]; other site
634458003668	AAA domain; Region: AAA_26; pfam13500
634458003669	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
634458003670	LexA repressor; Validated; Region: PRK00215
634458003671	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
634458003672	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634458003673	Catalytic site [active]
634458003674	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
634458003675	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
634458003676	dimer interface [polypeptide binding]; other site
634458003677	putative functional site; other site
634458003678	putative MPT binding site; other site
634458003679	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
634458003680	Septum formation initiator; Region: DivIC; cl17659
634458003681	enolase; Provisional; Region: eno; PRK00077
634458003682	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
634458003683	dimer interface [polypeptide binding]; other site
634458003684	metal binding site [ion binding]; metal-binding site
634458003685	substrate binding pocket [chemical binding]; other site
634458003686	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
634458003687	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
634458003688	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
634458003689	thiS-thiF/thiG interaction site; other site
634458003690	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
634458003691	ThiS interaction site; other site
634458003692	putative active site [active]
634458003693	tetramer interface [polypeptide binding]; other site
634458003694	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
634458003695	thiamine phosphate binding site [chemical binding]; other site
634458003696	active site
634458003697	pyrophosphate binding site [ion binding]; other site
634458003698	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
634458003699	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
634458003700	generic binding surface II; other site
634458003701	ssDNA binding site; other site
634458003702	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458003703	ATP binding site [chemical binding]; other site
634458003704	putative Mg++ binding site [ion binding]; other site
634458003705	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458003706	nucleotide binding region [chemical binding]; other site
634458003707	ATP-binding site [chemical binding]; other site
634458003708	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
634458003709	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
634458003710	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
634458003711	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458003712	ATP binding site [chemical binding]; other site
634458003713	putative Mg++ binding site [ion binding]; other site
634458003714	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458003715	nucleotide binding region [chemical binding]; other site
634458003716	ATP-binding site [chemical binding]; other site
634458003717	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
634458003718	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
634458003719	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
634458003720	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
634458003721	tyrosine decarboxylase; Region: PLN02880
634458003722	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
634458003723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458003724	catalytic residue [active]
634458003725	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
634458003726	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
634458003727	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
634458003728	metal ion-dependent adhesion site (MIDAS); other site
634458003729	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
634458003730	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
634458003731	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
634458003732	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634458003733	HSP70 interaction site [polypeptide binding]; other site
634458003734	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
634458003735	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
634458003736	lipoate-protein ligase B; Provisional; Region: PRK14341
634458003737	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
634458003738	active site
634458003739	tetramer interface; other site
634458003740	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
634458003741	active site
634458003742	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
634458003743	substrate binding site [chemical binding]; other site
634458003744	metal binding site [ion binding]; metal-binding site
634458003745	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
634458003746	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458003747	FeS/SAM binding site; other site
634458003748	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
634458003749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458003750	S-adenosylmethionine binding site [chemical binding]; other site
634458003751	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
634458003752	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634458003753	active site
634458003754	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
634458003755	GSH binding site [chemical binding]; other site
634458003756	catalytic residues [active]
634458003757	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
634458003758	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
634458003759	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
634458003760	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
634458003761	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458003762	S-adenosylmethionine binding site [chemical binding]; other site
634458003763	aspartate kinase; Reviewed; Region: PRK06635
634458003764	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
634458003765	putative nucleotide binding site [chemical binding]; other site
634458003766	putative catalytic residues [active]
634458003767	putative Mg ion binding site [ion binding]; other site
634458003768	putative aspartate binding site [chemical binding]; other site
634458003769	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
634458003770	putative allosteric regulatory site; other site
634458003771	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
634458003772	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
634458003773	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634458003774	FMN binding site [chemical binding]; other site
634458003775	substrate binding site [chemical binding]; other site
634458003776	putative catalytic residue [active]
634458003777	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
634458003778	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458003779	non-specific DNA binding site [nucleotide binding]; other site
634458003780	salt bridge; other site
634458003781	sequence-specific DNA binding site [nucleotide binding]; other site
634458003782	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
634458003783	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
634458003784	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
634458003785	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
634458003786	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
634458003787	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
634458003788	dimer interface [polypeptide binding]; other site
634458003789	motif 1; other site
634458003790	active site
634458003791	motif 2; other site
634458003792	motif 3; other site
634458003793	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
634458003794	anticodon binding site; other site
634458003795	peptide chain release factor 1; Validated; Region: prfA; PRK00591
634458003796	PCRF domain; Region: PCRF; pfam03462
634458003797	RF-1 domain; Region: RF-1; pfam00472
634458003798	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
634458003799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
634458003800	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
634458003801	mce related protein; Region: MCE; pfam02470
634458003802	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
634458003803	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
634458003804	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634458003805	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
634458003806	Transglycosylase SLT domain; Region: SLT_2; pfam13406
634458003807	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634458003808	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634458003809	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
634458003810	Sporulation related domain; Region: SPOR; cl10051
634458003811	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
634458003812	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
634458003813	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
634458003814	thymidylate kinase; Validated; Region: tmk; PRK00698
634458003815	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
634458003816	TMP-binding site; other site
634458003817	ATP-binding site [chemical binding]; other site
634458003818	DNA polymerase III subunit delta'; Validated; Region: PRK07471
634458003819	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458003820	Walker A motif; other site
634458003821	ATP binding site [chemical binding]; other site
634458003822	Walker B motif; other site
634458003823	arginine finger; other site
634458003824	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
634458003825	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
634458003826	active site
634458003827	HIGH motif; other site
634458003828	KMSKS motif; other site
634458003829	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
634458003830	tRNA binding surface [nucleotide binding]; other site
634458003831	anticodon binding site; other site
634458003832	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
634458003833	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
634458003834	active site
634458003835	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
634458003836	putative hydrolase; Provisional; Region: PRK02113
634458003837	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634458003838	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
634458003839	Ligand Binding Site [chemical binding]; other site
634458003840	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
634458003841	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
634458003842	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
634458003843	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
634458003844	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
634458003845	NAD binding site [chemical binding]; other site
634458003846	homotetramer interface [polypeptide binding]; other site
634458003847	homodimer interface [polypeptide binding]; other site
634458003848	substrate binding site [chemical binding]; other site
634458003849	active site
634458003850	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
634458003851	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
634458003852	Tetramer interface [polypeptide binding]; other site
634458003853	active site
634458003854	FMN-binding site [chemical binding]; other site
634458003855	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
634458003856	malate:quinone oxidoreductase; Validated; Region: PRK05257
634458003857	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
634458003858	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
634458003859	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
634458003860	Ligand Binding Site [chemical binding]; other site
634458003861	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
634458003862	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
634458003863	biotin synthase; Region: bioB; TIGR00433
634458003864	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458003865	FeS/SAM binding site; other site
634458003866	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
634458003867	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
634458003868	Domain of unknown function (DUF333); Region: DUF333; pfam03891
634458003869	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
634458003870	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
634458003871	Active Sites [active]
634458003872	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
634458003873	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
634458003874	Active Sites [active]
634458003875	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
634458003876	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
634458003877	G1 box; other site
634458003878	GTP/Mg2+ binding site [chemical binding]; other site
634458003879	G2 box; other site
634458003880	Switch I region; other site
634458003881	G3 box; other site
634458003882	Switch II region; other site
634458003883	G4 box; other site
634458003884	G5 box; other site
634458003885	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
634458003886	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
634458003887	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
634458003888	ligand-binding site [chemical binding]; other site
634458003889	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
634458003890	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
634458003891	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634458003892	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634458003893	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
634458003894	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
634458003895	putative acyl-acceptor binding pocket; other site
634458003896	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
634458003897	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
634458003898	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
634458003899	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
634458003900	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
634458003901	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
634458003902	putative acyl-acceptor binding pocket; other site
634458003903	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634458003904	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
634458003905	active site
634458003906	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
634458003907	putative amphipathic alpha helix; other site
634458003908	YceG-like family; Region: YceG; pfam02618
634458003909	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
634458003910	dimerization interface [polypeptide binding]; other site
634458003911	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
634458003912	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
634458003913	dimer interface [polypeptide binding]; other site
634458003914	active site
634458003915	acyl carrier protein; Provisional; Region: acpP; PRK00982
634458003916	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458003917	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
634458003918	NAD(P) binding site [chemical binding]; other site
634458003919	active site
634458003920	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
634458003921	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
634458003922	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
634458003923	putative active site [active]
634458003924	Methyltransferase domain; Region: Methyltransf_31; pfam13847
634458003925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458003926	S-adenosylmethionine binding site [chemical binding]; other site
634458003927	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
634458003928	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
634458003929	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634458003930	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458003931	catalytic residues [active]
634458003932	catalytic nucleophile [active]
634458003933	Presynaptic Site I dimer interface [polypeptide binding]; other site
634458003934	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634458003935	Synaptic Flat tetramer interface [polypeptide binding]; other site
634458003936	Synaptic Site I dimer interface [polypeptide binding]; other site
634458003937	DNA binding site [nucleotide binding]
634458003938	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458003939	DNA-binding interface [nucleotide binding]; DNA binding site
634458003940	Winged helix-turn helix; Region: HTH_29; pfam13551
634458003941	Helix-turn-helix domain; Region: HTH_28; pfam13518
634458003942	Homeodomain-like domain; Region: HTH_32; pfam13565
634458003943	Integrase core domain; Region: rve; pfam00665
634458003944	Integrase core domain; Region: rve_3; cl15866
634458003945	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
634458003946	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
634458003947	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634458003948	DNA-binding site [nucleotide binding]; DNA binding site
634458003949	RNA-binding motif; other site
634458003950	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634458003951	DNA-binding site [nucleotide binding]; DNA binding site
634458003952	RNA-binding motif; other site
634458003953	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
634458003954	SmpB-tmRNA interface; other site
634458003955	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
634458003956	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
634458003957	dimer interface [polypeptide binding]; other site
634458003958	active site
634458003959	catalytic residue [active]
634458003960	prephenate dehydratase; Provisional; Region: PRK11899
634458003961	Prephenate dehydratase; Region: PDT; pfam00800
634458003962	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
634458003963	putative L-Phe binding site [chemical binding]; other site
634458003964	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
634458003965	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
634458003966	Ligand binding site; other site
634458003967	oligomer interface; other site
634458003968	Cytochrome c; Region: Cytochrom_C; cl11414
634458003969	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634458003970	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
634458003971	active site
634458003972	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
634458003973	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
634458003974	ligand binding site [chemical binding]; other site
634458003975	NAD binding site [chemical binding]; other site
634458003976	tetramer interface [polypeptide binding]; other site
634458003977	catalytic site [active]
634458003978	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
634458003979	L-serine binding site [chemical binding]; other site
634458003980	ACT domain interface; other site
634458003981	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
634458003982	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
634458003983	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
634458003984	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
634458003985	cystathionine beta-lyase; Provisional; Region: PRK05967
634458003986	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
634458003987	homodimer interface [polypeptide binding]; other site
634458003988	substrate-cofactor binding pocket; other site
634458003989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458003990	catalytic residue [active]
634458003991	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
634458003992	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
634458003993	active site residue [active]
634458003994	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
634458003995	active site residue [active]
634458003996	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634458003997	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634458003998	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
634458003999	putative catalytic site [active]
634458004000	putative metal binding site [ion binding]; other site
634458004001	putative phosphate binding site [ion binding]; other site
634458004002	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
634458004003	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
634458004004	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
634458004005	putative active site [active]
634458004006	catalytic site [active]
634458004007	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
634458004008	putative active site [active]
634458004009	catalytic site [active]
634458004010	hypothetical protein; Reviewed; Region: PRK12497
634458004011	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
634458004012	putative GSH binding site [chemical binding]; other site
634458004013	catalytic residues [active]
634458004014	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
634458004015	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
634458004016	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
634458004017	dimerization interface [polypeptide binding]; other site
634458004018	ATP binding site [chemical binding]; other site
634458004019	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
634458004020	dimerization interface [polypeptide binding]; other site
634458004021	ATP binding site [chemical binding]; other site
634458004022	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
634458004023	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
634458004024	putative active site [active]
634458004025	catalytic triad [active]
634458004026	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
634458004027	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
634458004028	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
634458004029	ATP binding site [chemical binding]; other site
634458004030	active site
634458004031	substrate binding site [chemical binding]; other site
634458004032	adenylosuccinate lyase; Provisional; Region: PRK07492
634458004033	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
634458004034	tetramer interface [polypeptide binding]; other site
634458004035	active site
634458004036	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
634458004037	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
634458004038	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634458004039	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634458004040	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634458004041	catalytic residue [active]
634458004042	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
634458004043	tetramer interfaces [polypeptide binding]; other site
634458004044	binuclear metal-binding site [ion binding]; other site
634458004045	Competence-damaged protein; Region: CinA; pfam02464
634458004046	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
634458004047	putative coenzyme Q binding site [chemical binding]; other site
634458004048	lipoyl synthase; Provisional; Region: PRK05481
634458004049	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458004050	FeS/SAM binding site; other site
634458004051	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
634458004052	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634458004053	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
634458004054	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634458004055	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
634458004056	E3 interaction surface; other site
634458004057	lipoyl attachment site [posttranslational modification]; other site
634458004058	e3 binding domain; Region: E3_binding; pfam02817
634458004059	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
634458004060	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
634458004061	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634458004062	E3 interaction surface; other site
634458004063	lipoyl attachment site [posttranslational modification]; other site
634458004064	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
634458004065	alpha subunit interface [polypeptide binding]; other site
634458004066	TPP binding site [chemical binding]; other site
634458004067	heterodimer interface [polypeptide binding]; other site
634458004068	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634458004069	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
634458004070	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
634458004071	tetramer interface [polypeptide binding]; other site
634458004072	TPP-binding site [chemical binding]; other site
634458004073	heterodimer interface [polypeptide binding]; other site
634458004074	phosphorylation loop region [posttranslational modification]
634458004075	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
634458004076	trimer interface [polypeptide binding]; other site
634458004077	dimer interface [polypeptide binding]; other site
634458004078	putative active site [active]
634458004079	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
634458004080	active site
634458004081	ribulose/triose binding site [chemical binding]; other site
634458004082	phosphate binding site [ion binding]; other site
634458004083	substrate (anthranilate) binding pocket [chemical binding]; other site
634458004084	product (indole) binding pocket [chemical binding]; other site
634458004085	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
634458004086	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
634458004087	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
634458004088	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
634458004089	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
634458004090	glutamine binding [chemical binding]; other site
634458004091	catalytic triad [active]
634458004092	anthranilate synthase component I; Provisional; Region: PRK13573
634458004093	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
634458004094	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
634458004095	SurA N-terminal domain; Region: SurA_N_3; cl07813
634458004096	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
634458004097	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
634458004098	triosephosphate isomerase; Provisional; Region: PRK14565
634458004099	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
634458004100	substrate binding site [chemical binding]; other site
634458004101	dimer interface [polypeptide binding]; other site
634458004102	catalytic triad [active]
634458004103	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
634458004104	CTP synthetase; Validated; Region: pyrG; PRK05380
634458004105	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
634458004106	Catalytic site [active]
634458004107	active site
634458004108	UTP binding site [chemical binding]; other site
634458004109	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
634458004110	active site
634458004111	putative oxyanion hole; other site
634458004112	catalytic triad [active]
634458004113	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
634458004114	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
634458004115	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
634458004116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458004117	ATP binding site [chemical binding]; other site
634458004118	Mg2+ binding site [ion binding]; other site
634458004119	G-X-G motif; other site
634458004120	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
634458004121	anchoring element; other site
634458004122	dimer interface [polypeptide binding]; other site
634458004123	ATP binding site [chemical binding]; other site
634458004124	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
634458004125	active site
634458004126	putative metal-binding site [ion binding]; other site
634458004127	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
634458004128	recombination protein F; Reviewed; Region: recF; PRK00064
634458004129	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458004130	Walker A/P-loop; other site
634458004131	ATP binding site [chemical binding]; other site
634458004132	Q-loop/lid; other site
634458004133	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458004134	ABC transporter signature motif; other site
634458004135	Walker B; other site
634458004136	D-loop; other site
634458004137	H-loop/switch region; other site
634458004138	DNA polymerase III subunit beta; Validated; Region: PRK05643
634458004139	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
634458004140	putative DNA binding surface [nucleotide binding]; other site
634458004141	dimer interface [polypeptide binding]; other site
634458004142	beta-clamp/clamp loader binding surface; other site
634458004143	beta-clamp/translesion DNA polymerase binding surface; other site
634458004144	DnaA N-terminal domain; Region: DnaA_N; pfam11638
634458004145	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
634458004146	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458004147	Walker A motif; other site
634458004148	ATP binding site [chemical binding]; other site
634458004149	Walker B motif; other site
634458004150	arginine finger; other site
634458004151	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
634458004152	DnaA box-binding interface [nucleotide binding]; other site
634458004153	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
634458004154	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
634458004155	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
634458004156	DNA binding site [nucleotide binding]
634458004157	catalytic residue [active]
634458004158	H2TH interface [polypeptide binding]; other site
634458004159	putative catalytic residues [active]
634458004160	turnover-facilitating residue; other site
634458004161	intercalation triad [nucleotide binding]; other site
634458004162	8OG recognition residue [nucleotide binding]; other site
634458004163	putative reading head residues; other site
634458004164	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
634458004165	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
634458004166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458004167	S-adenosylmethionine binding site [chemical binding]; other site
634458004168	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
634458004169	Flavoprotein; Region: Flavoprotein; pfam02441
634458004170	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
634458004171	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
634458004172	trimer interface [polypeptide binding]; other site
634458004173	active site
634458004174	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
634458004175	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458004176	dimer interface [polypeptide binding]; other site
634458004177	conserved gate region; other site
634458004178	putative PBP binding loops; other site
634458004179	ABC-ATPase subunit interface; other site
634458004180	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634458004181	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634458004182	Walker A/P-loop; other site
634458004183	ATP binding site [chemical binding]; other site
634458004184	Q-loop/lid; other site
634458004185	ABC transporter signature motif; other site
634458004186	Walker B; other site
634458004187	D-loop; other site
634458004188	H-loop/switch region; other site
634458004189	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
634458004190	methionine sulfoxide reductase A; Provisional; Region: PRK14054
634458004191	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
634458004192	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
634458004193	HIGH motif; other site
634458004194	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
634458004195	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
634458004196	active site
634458004197	KMSKS motif; other site
634458004198	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
634458004199	tRNA binding surface [nucleotide binding]; other site
634458004200	anticodon binding site; other site
634458004201	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
634458004202	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
634458004203	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
634458004204	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
634458004205	Hint domain; Region: Hint_2; pfam13403
634458004206	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
634458004207	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458004208	NAD(P) binding site [chemical binding]; other site
634458004209	active site
634458004210	thiamine monophosphate kinase; Provisional; Region: PRK05731
634458004211	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
634458004212	ATP binding site [chemical binding]; other site
634458004213	dimerization interface [polypeptide binding]; other site
634458004214	transcription antitermination factor NusB; Region: nusB; TIGR01951
634458004215	putative RNA binding site [nucleotide binding]; other site
634458004216	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
634458004217	ATP cone domain; Region: ATP-cone; pfam03477
634458004218	Protein of unknown function (DUF461); Region: DUF461; pfam04314
634458004219	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
634458004220	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
634458004221	N- and C-terminal domain interface [polypeptide binding]; other site
634458004222	active site
634458004223	MgATP binding site [chemical binding]; other site
634458004224	catalytic site [active]
634458004225	metal binding site [ion binding]; metal-binding site
634458004226	glycerol binding site [chemical binding]; other site
634458004227	homotetramer interface [polypeptide binding]; other site
634458004228	homodimer interface [polypeptide binding]; other site
634458004229	FBP binding site [chemical binding]; other site
634458004230	protein IIAGlc interface [polypeptide binding]; other site
634458004231	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
634458004232	amphipathic channel; other site
634458004233	Asn-Pro-Ala signature motifs; other site
634458004234	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
634458004235	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
634458004236	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
634458004237	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
634458004238	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
634458004239	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458004240	ATP binding site [chemical binding]; other site
634458004241	putative Mg++ binding site [ion binding]; other site
634458004242	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458004243	nucleotide binding region [chemical binding]; other site
634458004244	ATP-binding site [chemical binding]; other site
634458004245	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
634458004246	HRDC domain; Region: HRDC; pfam00570
634458004247	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634458004248	ligand binding site [chemical binding]; other site
634458004249	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
634458004250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458004251	Walker A/P-loop; other site
634458004252	ATP binding site [chemical binding]; other site
634458004253	Q-loop/lid; other site
634458004254	ABC transporter signature motif; other site
634458004255	Walker B; other site
634458004256	D-loop; other site
634458004257	H-loop/switch region; other site
634458004258	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
634458004259	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458004260	Walker A/P-loop; other site
634458004261	ATP binding site [chemical binding]; other site
634458004262	Q-loop/lid; other site
634458004263	ABC transporter signature motif; other site
634458004264	Walker B; other site
634458004265	D-loop; other site
634458004266	H-loop/switch region; other site
634458004267	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
634458004268	Histidine kinase; Region: HisKA_2; pfam07568
634458004269	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458004270	ATP binding site [chemical binding]; other site
634458004271	Mg2+ binding site [ion binding]; other site
634458004272	G-X-G motif; other site
634458004273	RNA polymerase sigma factor; Provisional; Region: PRK12547
634458004274	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634458004275	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634458004276	DNA binding residues [nucleotide binding]
634458004277	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634458004278	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634458004279	DNA binding residues [nucleotide binding]
634458004280	two-component response regulator; Provisional; Region: PRK09191
634458004281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458004282	active site
634458004283	phosphorylation site [posttranslational modification]
634458004284	intermolecular recognition site; other site
634458004285	dimerization interface [polypeptide binding]; other site
634458004286	ABC transporter ATPase component; Reviewed; Region: PRK11147
634458004287	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634458004288	ABC transporter; Region: ABC_tran_2; pfam12848
634458004289	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634458004290	trehalase; Provisional; Region: treF; PRK13270
634458004291	Trehalase; Region: Trehalase; cl17346
634458004292	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
634458004293	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
634458004294	substrate binding site [chemical binding]; other site
634458004295	catalytic Zn binding site [ion binding]; other site
634458004296	NAD binding site [chemical binding]; other site
634458004297	structural Zn binding site [ion binding]; other site
634458004298	dimer interface [polypeptide binding]; other site
634458004299	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
634458004300	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
634458004301	PhnA protein; Region: PhnA; pfam03831
634458004302	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
634458004303	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
634458004304	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
634458004305	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
634458004306	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
634458004307	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
634458004308	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
634458004309	amidohydrolase; Provisional; Region: PRK12393
634458004310	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
634458004311	active site
634458004312	putative substrate binding pocket [chemical binding]; other site
634458004313	NMT1/THI5 like; Region: NMT1; pfam09084
634458004314	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
634458004315	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634458004316	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634458004317	Walker A/P-loop; other site
634458004318	ATP binding site [chemical binding]; other site
634458004319	Q-loop/lid; other site
634458004320	ABC transporter signature motif; other site
634458004321	Walker B; other site
634458004322	D-loop; other site
634458004323	H-loop/switch region; other site
634458004324	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634458004325	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458004326	dimer interface [polypeptide binding]; other site
634458004327	ABC-ATPase subunit interface; other site
634458004328	putative PBP binding loops; other site
634458004329	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
634458004330	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
634458004331	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
634458004332	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
634458004333	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
634458004334	active site
634458004335	putative substrate binding pocket [chemical binding]; other site
634458004336	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634458004337	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458004338	allantoate amidohydrolase; Reviewed; Region: PRK09290
634458004339	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
634458004340	active site
634458004341	metal binding site [ion binding]; metal-binding site
634458004342	dimer interface [polypeptide binding]; other site
634458004343	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
634458004344	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634458004345	catalytic residue [active]
634458004346	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
634458004347	SnoaL-like domain; Region: SnoaL_3; pfam13474
634458004348	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
634458004349	amidase; Provisional; Region: PRK09201
634458004350	Amidase; Region: Amidase; pfam01425
634458004351	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
634458004352	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
634458004353	XdhC Rossmann domain; Region: XdhC_C; pfam13478
634458004354	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
634458004355	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634458004356	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634458004357	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
634458004358	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634458004359	catalytic loop [active]
634458004360	iron binding site [ion binding]; other site
634458004361	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634458004362	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
634458004363	xanthine permease; Region: pbuX; TIGR03173
634458004364	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
634458004365	active site
634458004366	homotetramer interface [polypeptide binding]; other site
634458004367	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
634458004368	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
634458004369	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
634458004370	active site
634458004371	catalytic site [active]
634458004372	tetramer interface [polypeptide binding]; other site
634458004373	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
634458004374	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
634458004375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458004376	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458004377	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634458004378	dimerization interface [polypeptide binding]; other site
634458004379	guanine deaminase; Provisional; Region: PRK09228
634458004380	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
634458004381	active site
634458004382	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
634458004383	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
634458004384	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634458004385	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634458004386	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634458004387	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634458004388	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
634458004389	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634458004390	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
634458004391	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
634458004392	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458004393	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
634458004394	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
634458004395	Walker A/P-loop; other site
634458004396	ATP binding site [chemical binding]; other site
634458004397	Q-loop/lid; other site
634458004398	ABC transporter signature motif; other site
634458004399	Walker B; other site
634458004400	D-loop; other site
634458004401	H-loop/switch region; other site
634458004402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458004403	Walker A/P-loop; other site
634458004404	ATP binding site [chemical binding]; other site
634458004405	Q-loop/lid; other site
634458004406	ABC transporter signature motif; other site
634458004407	Walker B; other site
634458004408	D-loop; other site
634458004409	H-loop/switch region; other site
634458004410	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
634458004411	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
634458004412	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
634458004413	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
634458004414	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634458004415	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458004416	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458004417	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
634458004418	putative dimerization interface [polypeptide binding]; other site
634458004419	Predicted membrane protein [Function unknown]; Region: COG2855
634458004420	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
634458004421	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
634458004422	Active site cavity [active]
634458004423	catalytic acid [active]
634458004424	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458004425	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458004426	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458004427	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458004428	WHG domain; Region: WHG; pfam13305
634458004429	Secretory lipase; Region: LIP; pfam03583
634458004430	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
634458004431	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634458004432	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634458004433	NAD(P) binding site [chemical binding]; other site
634458004434	catalytic residues [active]
634458004435	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
634458004436	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
634458004437	FMN binding site [chemical binding]; other site
634458004438	active site
634458004439	substrate binding site [chemical binding]; other site
634458004440	catalytic residue [active]
634458004441	Predicted transcriptional regulators [Transcription]; Region: COG1733
634458004442	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
634458004443	hydroperoxidase II; Provisional; Region: katE; PRK11249
634458004444	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
634458004445	heme binding pocket [chemical binding]; other site
634458004446	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
634458004447	domain interactions; other site
634458004448	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
634458004449	hypothetical protein; Provisional; Region: PRK09256
634458004450	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634458004451	Putative glucoamylase; Region: Glycoamylase; pfam10091
634458004452	Putative glucoamylase; Region: Glycoamylase; pfam10091
634458004453	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
634458004454	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
634458004455	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
634458004456	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
634458004457	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634458004458	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
634458004459	active site
634458004460	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
634458004461	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634458004462	Coenzyme A binding pocket [chemical binding]; other site
634458004463	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
634458004464	dimer interface [polypeptide binding]; other site
634458004465	substrate binding site [chemical binding]; other site
634458004466	ATP binding site [chemical binding]; other site
634458004467	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
634458004468	ABC transporter signature motif; other site
634458004469	Walker B; other site
634458004470	D-loop; other site
634458004471	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458004472	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458004473	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
634458004474	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
634458004475	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
634458004476	Protein of unknown function DUF72; Region: DUF72; pfam01904
634458004477	Uncharacterized conserved protein [Function unknown]; Region: COG2135
634458004478	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
634458004479	putative chaperone; Provisional; Region: PRK11678
634458004480	nucleotide binding site [chemical binding]; other site
634458004481	putative NEF/HSP70 interaction site [polypeptide binding]; other site
634458004482	SBD interface [polypeptide binding]; other site
634458004483	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634458004484	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
634458004485	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
634458004486	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458004487	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
634458004488	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458004489	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458004490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
634458004491	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
634458004492	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
634458004493	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634458004494	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458004495	putative substrate translocation pore; other site
634458004496	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
634458004497	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
634458004498	active site
634458004499	hypothetical protein; Provisional; Region: PRK09945
634458004500	Hint domain; Region: Hint_2; pfam13403
634458004501	SnoaL-like domain; Region: SnoaL_2; pfam12680
634458004502	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
634458004503	Helix-turn-helix domain; Region: HTH_18; pfam12833
634458004504	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
634458004505	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
634458004506	putative deacylase active site [active]
634458004507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458004508	putative substrate translocation pore; other site
634458004509	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634458004510	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
634458004511	metal binding site 2 [ion binding]; metal-binding site
634458004512	putative DNA binding helix; other site
634458004513	metal binding site 1 [ion binding]; metal-binding site
634458004514	dimer interface [polypeptide binding]; other site
634458004515	structural Zn2+ binding site [ion binding]; other site
634458004516	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634458004517	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634458004518	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634458004519	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
634458004520	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
634458004521	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
634458004522	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458004523	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458004524	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458004525	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
634458004526	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
634458004527	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634458004528	ligand-binding site [chemical binding]; other site
634458004529	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458004530	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458004531	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458004532	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
634458004533	FecR protein; Region: FecR; pfam04773
634458004534	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634458004535	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
634458004536	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
634458004537	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
634458004538	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634458004539	N-terminal plug; other site
634458004540	ligand-binding site [chemical binding]; other site
634458004541	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
634458004542	FecR protein; Region: FecR; pfam04773
634458004543	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458004544	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458004545	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
634458004546	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634458004547	DNA binding residues [nucleotide binding]
634458004548	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
634458004549	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
634458004550	substrate binding pocket [chemical binding]; other site
634458004551	membrane-bound complex binding site; other site
634458004552	hinge residues; other site
634458004553	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
634458004554	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
634458004555	Walker A/P-loop; other site
634458004556	ATP binding site [chemical binding]; other site
634458004557	Q-loop/lid; other site
634458004558	ABC transporter signature motif; other site
634458004559	Walker B; other site
634458004560	D-loop; other site
634458004561	H-loop/switch region; other site
634458004562	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
634458004563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458004564	dimer interface [polypeptide binding]; other site
634458004565	conserved gate region; other site
634458004566	putative PBP binding loops; other site
634458004567	ABC-ATPase subunit interface; other site
634458004568	Secretory lipase; Region: LIP; pfam03583
634458004569	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
634458004570	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
634458004571	active site
634458004572	iron coordination sites [ion binding]; other site
634458004573	substrate binding pocket [chemical binding]; other site
634458004574	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458004575	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458004576	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458004577	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458004578	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458004579	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458004580	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
634458004581	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
634458004582	active site
634458004583	SAM binding site [chemical binding]; other site
634458004584	homodimer interface [polypeptide binding]; other site
634458004585	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
634458004586	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
634458004587	active site
634458004588	putative homodimer interface [polypeptide binding]; other site
634458004589	SAM binding site [chemical binding]; other site
634458004590	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
634458004591	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458004592	S-adenosylmethionine binding site [chemical binding]; other site
634458004593	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
634458004594	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
634458004595	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
634458004596	active site
634458004597	SAM binding site [chemical binding]; other site
634458004598	homodimer interface [polypeptide binding]; other site
634458004599	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
634458004600	active site
634458004601	SAM binding site [chemical binding]; other site
634458004602	homodimer interface [polypeptide binding]; other site
634458004603	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
634458004604	Precorrin-8X methylmutase; Region: CbiC; pfam02570
634458004605	precorrin-3B synthase; Region: CobG; TIGR02435
634458004606	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634458004607	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
634458004608	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
634458004609	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
634458004610	fumarate hydratase; Reviewed; Region: fumC; PRK00485
634458004611	Class II fumarases; Region: Fumarase_classII; cd01362
634458004612	active site
634458004613	tetramer interface [polypeptide binding]; other site
634458004614	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
634458004615	GAF domain; Region: GAF; cl17456
634458004616	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
634458004617	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
634458004618	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634458004619	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634458004620	Trp docking motif [polypeptide binding]; other site
634458004621	putative active site [active]
634458004622	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634458004623	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
634458004624	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
634458004625	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
634458004626	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
634458004627	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
634458004628	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
634458004629	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634458004630	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
634458004631	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634458004632	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
634458004633	propionate/acetate kinase; Provisional; Region: PRK12379
634458004634	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
634458004635	phosphate acetyltransferase; Provisional; Region: PRK11890
634458004636	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
634458004637	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
634458004638	phosphate binding site [ion binding]; other site
634458004639	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
634458004640	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
634458004641	dimer interface [polypeptide binding]; other site
634458004642	PYR/PP interface [polypeptide binding]; other site
634458004643	TPP binding site [chemical binding]; other site
634458004644	substrate binding site [chemical binding]; other site
634458004645	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
634458004646	Domain of unknown function; Region: EKR; pfam10371
634458004647	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
634458004648	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
634458004649	TPP-binding site [chemical binding]; other site
634458004650	dimer interface [polypeptide binding]; other site
634458004651	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
634458004652	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634458004653	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634458004654	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
634458004655	Ca2+ binding site [ion binding]; other site
634458004656	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458004657	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458004658	Predicted membrane protein [Function unknown]; Region: COG1971
634458004659	Domain of unknown function DUF; Region: DUF204; pfam02659
634458004660	Domain of unknown function DUF; Region: DUF204; pfam02659
634458004661	glutathionine S-transferase; Provisional; Region: PRK10542
634458004662	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
634458004663	C-terminal domain interface [polypeptide binding]; other site
634458004664	GSH binding site (G-site) [chemical binding]; other site
634458004665	dimer interface [polypeptide binding]; other site
634458004666	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
634458004667	dimer interface [polypeptide binding]; other site
634458004668	N-terminal domain interface [polypeptide binding]; other site
634458004669	substrate binding pocket (H-site) [chemical binding]; other site
634458004670	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
634458004671	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
634458004672	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
634458004673	GTP binding site; other site
634458004674	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
634458004675	Walker A motif; other site
634458004676	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
634458004677	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
634458004678	dimer interface [polypeptide binding]; other site
634458004679	putative functional site; other site
634458004680	putative MPT binding site; other site
634458004681	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
634458004682	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
634458004683	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634458004684	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
634458004685	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
634458004686	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
634458004687	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
634458004688	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
634458004689	[4Fe-4S] binding site [ion binding]; other site
634458004690	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
634458004691	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
634458004692	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
634458004693	molybdopterin cofactor binding site; other site
634458004694	exopolyphosphatase; Region: exo_poly_only; TIGR03706
634458004695	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
634458004696	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
634458004697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458004698	S-adenosylmethionine binding site [chemical binding]; other site
634458004699	fructokinase; Reviewed; Region: PRK09557
634458004700	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634458004701	nucleotide binding site [chemical binding]; other site
634458004702	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
634458004703	CPxP  motif; other site
634458004704	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
634458004705	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
634458004706	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
634458004707	substrate binding pocket [chemical binding]; other site
634458004708	chain length determination region; other site
634458004709	substrate-Mg2+ binding site; other site
634458004710	catalytic residues [active]
634458004711	aspartate-rich region 1; other site
634458004712	active site lid residues [active]
634458004713	aspartate-rich region 2; other site
634458004714	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
634458004715	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
634458004716	TPP-binding site; other site
634458004717	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634458004718	PYR/PP interface [polypeptide binding]; other site
634458004719	dimer interface [polypeptide binding]; other site
634458004720	TPP binding site [chemical binding]; other site
634458004721	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634458004722	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
634458004723	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634458004724	RNA binding surface [nucleotide binding]; other site
634458004725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458004726	S-adenosylmethionine binding site [chemical binding]; other site
634458004727	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
634458004728	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458004729	FeS/SAM binding site; other site
634458004730	argininosuccinate synthase; Provisional; Region: PRK13820
634458004731	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
634458004732	ANP binding site [chemical binding]; other site
634458004733	Substrate Binding Site II [chemical binding]; other site
634458004734	Substrate Binding Site I [chemical binding]; other site
634458004735	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
634458004736	Cytochrome c; Region: Cytochrom_C; pfam00034
634458004737	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
634458004738	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
634458004739	active site
634458004740	HIGH motif; other site
634458004741	dimer interface [polypeptide binding]; other site
634458004742	KMSKS motif; other site
634458004743	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634458004744	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634458004745	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458004746	active site
634458004747	phosphorylation site [posttranslational modification]
634458004748	intermolecular recognition site; other site
634458004749	dimerization interface [polypeptide binding]; other site
634458004750	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458004751	DNA binding site [nucleotide binding]
634458004752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
634458004753	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
634458004754	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
634458004755	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458004756	S-adenosylmethionine binding site [chemical binding]; other site
634458004757	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
634458004758	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
634458004759	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
634458004760	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
634458004761	active site
634458004762	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
634458004763	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
634458004764	peptide binding site [polypeptide binding]; other site
634458004765	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
634458004766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458004767	dimer interface [polypeptide binding]; other site
634458004768	conserved gate region; other site
634458004769	ABC-ATPase subunit interface; other site
634458004770	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
634458004771	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458004772	dimer interface [polypeptide binding]; other site
634458004773	conserved gate region; other site
634458004774	putative PBP binding loops; other site
634458004775	ABC-ATPase subunit interface; other site
634458004776	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
634458004777	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
634458004778	Walker A/P-loop; other site
634458004779	ATP binding site [chemical binding]; other site
634458004780	Q-loop/lid; other site
634458004781	ABC transporter signature motif; other site
634458004782	Walker B; other site
634458004783	D-loop; other site
634458004784	H-loop/switch region; other site
634458004785	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
634458004786	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
634458004787	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
634458004788	Walker A/P-loop; other site
634458004789	ATP binding site [chemical binding]; other site
634458004790	Q-loop/lid; other site
634458004791	ABC transporter signature motif; other site
634458004792	Walker B; other site
634458004793	D-loop; other site
634458004794	H-loop/switch region; other site
634458004795	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
634458004796	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
634458004797	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634458004798	FMN binding site [chemical binding]; other site
634458004799	substrate binding site [chemical binding]; other site
634458004800	putative catalytic residue [active]
634458004801	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
634458004802	active site
634458004803	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
634458004804	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
634458004805	CAS motifs; other site
634458004806	active site
634458004807	Purine nucleoside permease (NUP); Region: NUP; pfam06516
634458004808	Phosphoesterase family; Region: Phosphoesterase; pfam04185
634458004809	Phosphoesterase family; Region: Phosphoesterase; pfam04185
634458004810	Domain of unknown function (DUF756); Region: DUF756; pfam05506
634458004811	Domain of unknown function (DUF756); Region: DUF756; pfam05506
634458004812	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458004813	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458004814	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
634458004815	Tannase and feruloyl esterase; Region: Tannase; pfam07519
634458004816	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634458004817	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458004818	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634458004819	putative substrate translocation pore; other site
634458004820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458004821	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
634458004822	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
634458004823	FAD binding pocket [chemical binding]; other site
634458004824	FAD binding motif [chemical binding]; other site
634458004825	phosphate binding motif [ion binding]; other site
634458004826	NAD binding pocket [chemical binding]; other site
634458004827	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
634458004828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458004829	S-adenosylmethionine binding site [chemical binding]; other site
634458004830	Predicted transcriptional regulators [Transcription]; Region: COG1695
634458004831	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
634458004832	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458004833	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458004834	multidrug resistance protein MdtN; Provisional; Region: PRK10476
634458004835	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458004836	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458004837	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634458004838	Outer membrane efflux protein; Region: OEP; pfam02321
634458004839	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
634458004840	B12 binding site [chemical binding]; other site
634458004841	Radical SAM superfamily; Region: Radical_SAM; pfam04055
634458004842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
634458004843	FeS/SAM binding site; other site
634458004844	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
634458004845	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
634458004846	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634458004847	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634458004848	N-terminal plug; other site
634458004849	ligand-binding site [chemical binding]; other site
634458004850	Conserved TM helix; Region: TM_helix; pfam05552
634458004851	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634458004852	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
634458004853	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
634458004854	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
634458004855	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
634458004856	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
634458004857	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
634458004858	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458004859	Walker A/P-loop; other site
634458004860	ATP binding site [chemical binding]; other site
634458004861	Q-loop/lid; other site
634458004862	ABC transporter signature motif; other site
634458004863	Walker B; other site
634458004864	D-loop; other site
634458004865	H-loop/switch region; other site
634458004866	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
634458004867	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634458004868	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458004869	Walker A/P-loop; other site
634458004870	ATP binding site [chemical binding]; other site
634458004871	Q-loop/lid; other site
634458004872	ABC transporter signature motif; other site
634458004873	Walker B; other site
634458004874	D-loop; other site
634458004875	H-loop/switch region; other site
634458004876	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
634458004877	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
634458004878	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634458004879	N-terminal plug; other site
634458004880	ligand-binding site [chemical binding]; other site
634458004881	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634458004882	Sel1-like repeats; Region: SEL1; smart00671
634458004883	Sel1-like repeats; Region: SEL1; smart00671
634458004884	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458004885	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458004886	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
634458004887	active site
634458004888	homotetramer interface [polypeptide binding]; other site
634458004889	homodimer interface [polypeptide binding]; other site
634458004890	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
634458004891	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458004892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458004893	homodimer interface [polypeptide binding]; other site
634458004894	catalytic residue [active]
634458004895	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
634458004896	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
634458004897	TrkA-C domain; Region: TrkA_C; pfam02080
634458004898	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
634458004899	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
634458004900	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634458004901	active site
634458004902	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
634458004903	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634458004904	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634458004905	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458004906	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
634458004907	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634458004908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458004909	Walker A/P-loop; other site
634458004910	ATP binding site [chemical binding]; other site
634458004911	Q-loop/lid; other site
634458004912	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634458004913	ABC transporter signature motif; other site
634458004914	Walker B; other site
634458004915	ABC transporter; Region: ABC_tran_2; pfam12848
634458004916	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634458004917	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458004918	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458004919	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634458004920	dimerization interface [polypeptide binding]; other site
634458004921	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458004922	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
634458004923	Hint domain; Region: Hint_2; pfam13403
634458004924	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458004925	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634458004926	N-terminal plug; other site
634458004927	ligand-binding site [chemical binding]; other site
634458004928	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
634458004929	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
634458004930	putative NAD(P) binding site [chemical binding]; other site
634458004931	putative substrate binding site [chemical binding]; other site
634458004932	catalytic Zn binding site [ion binding]; other site
634458004933	structural Zn binding site [ion binding]; other site
634458004934	dimer interface [polypeptide binding]; other site
634458004935	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458004936	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
634458004937	SnoaL-like domain; Region: SnoaL_2; pfam12680
634458004938	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
634458004939	dimerization interface [polypeptide binding]; other site
634458004940	metal binding site [ion binding]; metal-binding site
634458004941	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634458004942	catalytic core [active]
634458004943	MgtC family; Region: MgtC; pfam02308
634458004944	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
634458004945	putative CoA-transferase; Provisional; Region: PRK11430
634458004946	CoA-transferase family III; Region: CoA_transf_3; pfam02515
634458004947	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
634458004948	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458004949	oxalyl-CoA decarboxylase; Region: oxalate_oxc; TIGR03254
634458004950	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634458004951	PYR/PP interface [polypeptide binding]; other site
634458004952	dimer interface [polypeptide binding]; other site
634458004953	TPP binding site [chemical binding]; other site
634458004954	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634458004955	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
634458004956	TPP-binding site; other site
634458004957	dimer interface [polypeptide binding]; other site
634458004958	formyl-coenzyme A transferase; Provisional; Region: PRK05398
634458004959	CoA-transferase family III; Region: CoA_transf_3; pfam02515
634458004960	oxidoreductase; Provisional; Region: PRK12742
634458004961	classical (c) SDRs; Region: SDR_c; cd05233
634458004962	NAD(P) binding site [chemical binding]; other site
634458004963	active site
634458004964	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458004965	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458004966	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
634458004967	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458004968	NAD(P) binding site [chemical binding]; other site
634458004969	active site
634458004970	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
634458004971	putative hydrophobic ligand binding site [chemical binding]; other site
634458004972	protein interface [polypeptide binding]; other site
634458004973	gate; other site
634458004974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458004975	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634458004976	putative substrate translocation pore; other site
634458004977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458004978	phosphoglucomutase; Validated; Region: PRK07564
634458004979	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
634458004980	active site
634458004981	substrate binding site [chemical binding]; other site
634458004982	metal binding site [ion binding]; metal-binding site
634458004983	maltose O-acetyltransferase; Provisional; Region: PRK10092
634458004984	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
634458004985	active site
634458004986	substrate binding site [chemical binding]; other site
634458004987	trimer interface [polypeptide binding]; other site
634458004988	CoA binding site [chemical binding]; other site
634458004989	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
634458004990	Hint domain; Region: Hint_2; pfam13403
634458004991	HTH-like domain; Region: HTH_21; pfam13276
634458004992	Integrase core domain; Region: rve; pfam00665
634458004993	Integrase core domain; Region: rve_3; pfam13683
634458004994	Transposase; Region: HTH_Tnp_1; pfam01527
634458004995	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
634458004996	FecR protein; Region: FecR; pfam04773
634458004997	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
634458004998	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634458004999	DNA binding residues [nucleotide binding]
634458005000	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
634458005001	sensor protein QseC; Provisional; Region: PRK10337
634458005002	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634458005003	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458005004	dimer interface [polypeptide binding]; other site
634458005005	phosphorylation site [posttranslational modification]
634458005006	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634458005007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458005008	active site
634458005009	phosphorylation site [posttranslational modification]
634458005010	intermolecular recognition site; other site
634458005011	dimerization interface [polypeptide binding]; other site
634458005012	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458005013	DNA binding site [nucleotide binding]
634458005014	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
634458005015	HlyD family secretion protein; Region: HlyD_2; pfam12700
634458005016	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458005017	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458005018	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
634458005019	Outer membrane efflux protein; Region: OEP; pfam02321
634458005020	acyl-CoA synthetase; Validated; Region: PRK09192
634458005021	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
634458005022	acyl-activating enzyme (AAE) consensus motif; other site
634458005023	active site
634458005024	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
634458005025	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
634458005026	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
634458005027	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634458005028	catalytic residue [active]
634458005029	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
634458005030	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
634458005031	active site
634458005032	metal binding site [ion binding]; metal-binding site
634458005033	Predicted permeases [General function prediction only]; Region: COG0795
634458005034	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634458005035	Predicted permeases [General function prediction only]; Region: COG0795
634458005036	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
634458005037	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
634458005038	active site
634458005039	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
634458005040	phosphoglycolate phosphatase; Provisional; Region: PRK13222
634458005041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458005042	motif II; other site
634458005043	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
634458005044	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
634458005045	Substrate binding site; other site
634458005046	Mg++ binding site; other site
634458005047	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
634458005048	active site
634458005049	substrate binding site [chemical binding]; other site
634458005050	CoA binding site [chemical binding]; other site
634458005051	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
634458005052	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
634458005053	glutaminase active site [active]
634458005054	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
634458005055	dimer interface [polypeptide binding]; other site
634458005056	active site
634458005057	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
634458005058	dimer interface [polypeptide binding]; other site
634458005059	active site
634458005060	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458005061	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458005062	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458005063	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458005064	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458005065	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
634458005066	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
634458005067	Transcriptional regulator [Transcription]; Region: IclR; COG1414
634458005068	Bacterial transcriptional regulator; Region: IclR; pfam01614
634458005069	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
634458005070	catalytic residues [active]
634458005071	dimer interface [polypeptide binding]; other site
634458005072	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
634458005073	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
634458005074	Walker A/P-loop; other site
634458005075	ATP binding site [chemical binding]; other site
634458005076	Q-loop/lid; other site
634458005077	ABC transporter signature motif; other site
634458005078	Walker B; other site
634458005079	D-loop; other site
634458005080	H-loop/switch region; other site
634458005081	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
634458005082	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
634458005083	FtsX-like permease family; Region: FtsX; pfam02687
634458005084	prolyl-tRNA synthetase; Provisional; Region: PRK12325
634458005085	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
634458005086	dimer interface [polypeptide binding]; other site
634458005087	motif 1; other site
634458005088	active site
634458005089	motif 2; other site
634458005090	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
634458005091	active site
634458005092	motif 3; other site
634458005093	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
634458005094	anticodon binding site; other site
634458005095	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
634458005096	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
634458005097	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
634458005098	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
634458005099	nucleotide binding site [chemical binding]; other site
634458005100	Type III pantothenate kinase; Region: Pan_kinase; cl17198
634458005101	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
634458005102	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
634458005103	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
634458005104	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
634458005105	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634458005106	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
634458005107	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
634458005108	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
634458005109	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
634458005110	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
634458005111	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
634458005112	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
634458005113	4Fe-4S binding domain; Region: Fer4; cl02805
634458005114	4Fe-4S binding domain; Region: Fer4; pfam00037
634458005115	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
634458005116	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
634458005117	NADH dehydrogenase subunit G; Validated; Region: PRK09130
634458005118	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634458005119	catalytic loop [active]
634458005120	iron binding site [ion binding]; other site
634458005121	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
634458005122	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
634458005123	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
634458005124	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
634458005125	SLBB domain; Region: SLBB; pfam10531
634458005126	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
634458005127	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
634458005128	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
634458005129	putative dimer interface [polypeptide binding]; other site
634458005130	[2Fe-2S] cluster binding site [ion binding]; other site
634458005131	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
634458005132	NADH dehydrogenase subunit D; Validated; Region: PRK06075
634458005133	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
634458005134	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
634458005135	NADH dehydrogenase subunit B; Validated; Region: PRK06411
634458005136	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
634458005137	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634458005138	IHF dimer interface [polypeptide binding]; other site
634458005139	IHF - DNA interface [nucleotide binding]; other site
634458005140	Found in ATP-dependent protease La (LON); Region: LON; smart00464
634458005141	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
634458005142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458005143	Walker A motif; other site
634458005144	ATP binding site [chemical binding]; other site
634458005145	Walker B motif; other site
634458005146	arginine finger; other site
634458005147	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
634458005148	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
634458005149	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
634458005150	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458005151	Walker A motif; other site
634458005152	ATP binding site [chemical binding]; other site
634458005153	Walker B motif; other site
634458005154	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
634458005155	Clp protease; Region: CLP_protease; pfam00574
634458005156	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
634458005157	oligomer interface [polypeptide binding]; other site
634458005158	active site residues [active]
634458005159	trigger factor; Provisional; Region: tig; PRK01490
634458005160	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
634458005161	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
634458005162	Uncharacterized conserved protein [Function unknown]; Region: COG0062
634458005163	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
634458005164	putative substrate binding site [chemical binding]; other site
634458005165	putative ATP binding site [chemical binding]; other site
634458005166	Predicted integral membrane protein [Function unknown]; Region: COG5615
634458005167	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
634458005168	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634458005169	ATP binding site [chemical binding]; other site
634458005170	Mg++ binding site [ion binding]; other site
634458005171	motif III; other site
634458005172	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458005173	nucleotide binding region [chemical binding]; other site
634458005174	ATP-binding site [chemical binding]; other site
634458005175	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
634458005176	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
634458005177	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
634458005178	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
634458005179	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
634458005180	trimerization site [polypeptide binding]; other site
634458005181	active site
634458005182	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
634458005183	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
634458005184	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634458005185	catalytic residue [active]
634458005186	FeS assembly protein SufD; Region: sufD; TIGR01981
634458005187	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
634458005188	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
634458005189	FeS assembly ATPase SufC; Region: sufC; TIGR01978
634458005190	Walker A/P-loop; other site
634458005191	ATP binding site [chemical binding]; other site
634458005192	Q-loop/lid; other site
634458005193	ABC transporter signature motif; other site
634458005194	Walker B; other site
634458005195	D-loop; other site
634458005196	H-loop/switch region; other site
634458005197	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
634458005198	putative ABC transporter; Region: ycf24; CHL00085
634458005199	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
634458005200	Transcriptional regulator; Region: Rrf2; pfam02082
634458005201	Transcriptional regulator; Region: Rrf2; cl17282
634458005202	Protein of unknown function (DUF445); Region: DUF445; pfam04286
634458005203	Peroxin-3; Region: Peroxin-3; pfam04882
634458005204	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
634458005205	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634458005206	elongation factor G; Reviewed; Region: PRK12739
634458005207	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
634458005208	G1 box; other site
634458005209	putative GEF interaction site [polypeptide binding]; other site
634458005210	GTP/Mg2+ binding site [chemical binding]; other site
634458005211	Switch I region; other site
634458005212	G2 box; other site
634458005213	G3 box; other site
634458005214	Switch II region; other site
634458005215	G4 box; other site
634458005216	G5 box; other site
634458005217	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
634458005218	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
634458005219	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
634458005220	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
634458005221	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634458005222	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
634458005223	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
634458005224	Walker A/P-loop; other site
634458005225	ATP binding site [chemical binding]; other site
634458005226	Q-loop/lid; other site
634458005227	ABC transporter signature motif; other site
634458005228	Walker B; other site
634458005229	D-loop; other site
634458005230	H-loop/switch region; other site
634458005231	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
634458005232	nudix motif; other site
634458005233	PII uridylyl-transferase; Provisional; Region: PRK05092
634458005234	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
634458005235	metal binding triad; other site
634458005236	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
634458005237	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
634458005238	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
634458005239	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
634458005240	MutS domain I; Region: MutS_I; pfam01624
634458005241	MutS domain II; Region: MutS_II; pfam05188
634458005242	MutS domain III; Region: MutS_III; pfam05192
634458005243	MutS domain V; Region: MutS_V; pfam00488
634458005244	Walker A/P-loop; other site
634458005245	ATP binding site [chemical binding]; other site
634458005246	Q-loop/lid; other site
634458005247	ABC transporter signature motif; other site
634458005248	Walker B; other site
634458005249	D-loop; other site
634458005250	H-loop/switch region; other site
634458005251	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
634458005252	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634458005253	binding surface
634458005254	TPR motif; other site
634458005255	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634458005256	binding surface
634458005257	TPR motif; other site
634458005258	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
634458005259	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
634458005260	active site
634458005261	Zn binding site [ion binding]; other site
634458005262	Major royal jelly protein; Region: MRJP; pfam03022
634458005263	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
634458005264	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
634458005265	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458005266	catalytic residue [active]
634458005267	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
634458005268	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
634458005269	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
634458005270	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
634458005271	Tim44-like domain; Region: Tim44; pfam04280
634458005272	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
634458005273	UbiA prenyltransferase family; Region: UbiA; pfam01040
634458005274	cytochrome c oxidase subunit I; Provisional; Region: COX1; MTH00182
634458005275	cytochrome c oxidase subunit I; Provisional; Region: COX1; MTH00182
634458005276	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458005277	S-adenosylmethionine binding site [chemical binding]; other site
634458005278	glutathione synthetase; Provisional; Region: PRK05246
634458005279	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
634458005280	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
634458005281	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
634458005282	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
634458005283	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
634458005284	Ligand binding site; other site
634458005285	Putative Catalytic site; other site
634458005286	DXD motif; other site
634458005287	Predicted membrane protein [Function unknown]; Region: COG2246
634458005288	GtrA-like protein; Region: GtrA; pfam04138
634458005289	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634458005290	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
634458005291	putative Zn2+ binding site [ion binding]; other site
634458005292	AsnC family; Region: AsnC_trans_reg; pfam01037
634458005293	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
634458005294	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634458005295	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634458005296	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458005297	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458005298	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634458005299	putative effector binding pocket; other site
634458005300	dimerization interface [polypeptide binding]; other site
634458005301	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
634458005302	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634458005303	IHF - DNA interface [nucleotide binding]; other site
634458005304	IHF dimer interface [polypeptide binding]; other site
634458005305	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
634458005306	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
634458005307	Fe-S cluster binding site [ion binding]; other site
634458005308	active site
634458005309	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
634458005310	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
634458005311	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634458005312	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634458005313	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
634458005314	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
634458005315	DNA binding residues [nucleotide binding]
634458005316	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634458005317	IHF - DNA interface [nucleotide binding]; other site
634458005318	IHF dimer interface [polypeptide binding]; other site
634458005319	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
634458005320	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
634458005321	dimer interface [polypeptide binding]; other site
634458005322	active site
634458005323	CoA binding pocket [chemical binding]; other site
634458005324	putative phosphate acyltransferase; Provisional; Region: PRK05331
634458005325	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
634458005326	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
634458005327	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
634458005328	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
634458005329	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
634458005330	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634458005331	dimerization interface [polypeptide binding]; other site
634458005332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458005333	ATP binding site [chemical binding]; other site
634458005334	Mg2+ binding site [ion binding]; other site
634458005335	G-X-G motif; other site
634458005336	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634458005337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458005338	active site
634458005339	phosphorylation site [posttranslational modification]
634458005340	intermolecular recognition site; other site
634458005341	dimerization interface [polypeptide binding]; other site
634458005342	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458005343	DNA binding site [nucleotide binding]
634458005344	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634458005345	MarR family; Region: MarR_2; pfam12802
634458005346	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
634458005347	COQ9; Region: COQ9; pfam08511
634458005348	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
634458005349	active site
634458005350	catalytic residues [active]
634458005351	metal binding site [ion binding]; metal-binding site
634458005352	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
634458005353	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
634458005354	tartrate dehydrogenase; Region: TTC; TIGR02089
634458005355	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
634458005356	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
634458005357	substrate binding site [chemical binding]; other site
634458005358	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
634458005359	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
634458005360	substrate binding site [chemical binding]; other site
634458005361	ligand binding site [chemical binding]; other site
634458005362	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
634458005363	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
634458005364	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
634458005365	RimM N-terminal domain; Region: RimM; pfam01782
634458005366	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
634458005367	signal recognition particle protein; Provisional; Region: PRK10867
634458005368	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
634458005369	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
634458005370	P loop; other site
634458005371	GTP binding site [chemical binding]; other site
634458005372	Signal peptide binding domain; Region: SRP_SPB; pfam02978
634458005373	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
634458005374	dimer interface [polypeptide binding]; other site
634458005375	ATP12 chaperone protein; Region: ATP12; pfam07542
634458005376	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
634458005377	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634458005378	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634458005379	RNA binding surface [nucleotide binding]; other site
634458005380	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634458005381	active site
634458005382	recombination factor protein RarA; Reviewed; Region: PRK13342
634458005383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458005384	Walker A motif; other site
634458005385	ATP binding site [chemical binding]; other site
634458005386	Walker B motif; other site
634458005387	arginine finger; other site
634458005388	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
634458005389	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
634458005390	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
634458005391	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
634458005392	UbiA prenyltransferase family; Region: UbiA; pfam01040
634458005393	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
634458005394	RNA methyltransferase, RsmE family; Region: TIGR00046
634458005395	glutamate--cysteine ligase; Region: PLN02611
634458005396	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458005397	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634458005398	putative substrate translocation pore; other site
634458005399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458005400	GTP-binding protein Der; Reviewed; Region: PRK00093
634458005401	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
634458005402	G1 box; other site
634458005403	GTP/Mg2+ binding site [chemical binding]; other site
634458005404	Switch I region; other site
634458005405	G2 box; other site
634458005406	Switch II region; other site
634458005407	G3 box; other site
634458005408	G4 box; other site
634458005409	G5 box; other site
634458005410	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
634458005411	G1 box; other site
634458005412	GTP/Mg2+ binding site [chemical binding]; other site
634458005413	Switch I region; other site
634458005414	G2 box; other site
634458005415	G3 box; other site
634458005416	Switch II region; other site
634458005417	G4 box; other site
634458005418	G5 box; other site
634458005419	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
634458005420	Trp docking motif [polypeptide binding]; other site
634458005421	active site
634458005422	PQQ-like domain; Region: PQQ_2; pfam13360
634458005423	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
634458005424	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
634458005425	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
634458005426	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
634458005427	putative active site [active]
634458005428	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
634458005429	putative ADP-binding pocket [chemical binding]; other site
634458005430	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458005431	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
634458005432	active site
634458005433	dimer interface [polypeptide binding]; other site
634458005434	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
634458005435	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
634458005436	Ligand Binding Site [chemical binding]; other site
634458005437	Molecular Tunnel; other site
634458005438	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
634458005439	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
634458005440	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
634458005441	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
634458005442	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
634458005443	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
634458005444	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
634458005445	Sulfate transporter family; Region: Sulfate_transp; pfam00916
634458005446	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
634458005447	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
634458005448	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
634458005449	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
634458005450	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
634458005451	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
634458005452	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
634458005453	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
634458005454	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
634458005455	Clp amino terminal domain; Region: Clp_N; pfam02861
634458005456	Clp amino terminal domain; Region: Clp_N; pfam02861
634458005457	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458005458	Walker A motif; other site
634458005459	ATP binding site [chemical binding]; other site
634458005460	Walker B motif; other site
634458005461	arginine finger; other site
634458005462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458005463	Walker A motif; other site
634458005464	ATP binding site [chemical binding]; other site
634458005465	Walker B motif; other site
634458005466	arginine finger; other site
634458005467	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
634458005468	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
634458005469	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
634458005470	nudix motif; other site
634458005471	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
634458005472	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
634458005473	HflX GTPase family; Region: HflX; cd01878
634458005474	G1 box; other site
634458005475	GTP/Mg2+ binding site [chemical binding]; other site
634458005476	Switch I region; other site
634458005477	G2 box; other site
634458005478	G3 box; other site
634458005479	Switch II region; other site
634458005480	G4 box; other site
634458005481	G5 box; other site
634458005482	bacterial Hfq-like; Region: Hfq; cd01716
634458005483	hexamer interface [polypeptide binding]; other site
634458005484	Sm1 motif; other site
634458005485	RNA binding site [nucleotide binding]; other site
634458005486	Sm2 motif; other site
634458005487	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
634458005488	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458005489	active site
634458005490	phosphorylation site [posttranslational modification]
634458005491	intermolecular recognition site; other site
634458005492	dimerization interface [polypeptide binding]; other site
634458005493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458005494	Walker A motif; other site
634458005495	ATP binding site [chemical binding]; other site
634458005496	Walker B motif; other site
634458005497	arginine finger; other site
634458005498	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
634458005499	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
634458005500	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
634458005501	dimerization interface [polypeptide binding]; other site
634458005502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458005503	dimer interface [polypeptide binding]; other site
634458005504	phosphorylation site [posttranslational modification]
634458005505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458005506	ATP binding site [chemical binding]; other site
634458005507	Mg2+ binding site [ion binding]; other site
634458005508	G-X-G motif; other site
634458005509	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
634458005510	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458005511	active site
634458005512	phosphorylation site [posttranslational modification]
634458005513	intermolecular recognition site; other site
634458005514	dimerization interface [polypeptide binding]; other site
634458005515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458005516	Walker A motif; other site
634458005517	ATP binding site [chemical binding]; other site
634458005518	Walker B motif; other site
634458005519	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
634458005520	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
634458005521	PAS domain; Region: PAS; smart00091
634458005522	putative active site [active]
634458005523	heme pocket [chemical binding]; other site
634458005524	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458005525	dimer interface [polypeptide binding]; other site
634458005526	phosphorylation site [posttranslational modification]
634458005527	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458005528	ATP binding site [chemical binding]; other site
634458005529	Mg2+ binding site [ion binding]; other site
634458005530	G-X-G motif; other site
634458005531	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
634458005532	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
634458005533	FMN binding site [chemical binding]; other site
634458005534	active site
634458005535	catalytic residues [active]
634458005536	substrate binding site [chemical binding]; other site
634458005537	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
634458005538	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
634458005539	substrate binding site; other site
634458005540	dimer interface; other site
634458005541	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
634458005542	homotrimer interaction site [polypeptide binding]; other site
634458005543	zinc binding site [ion binding]; other site
634458005544	CDP-binding sites; other site
634458005545	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
634458005546	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
634458005547	Ligand binding site; other site
634458005548	Putative Catalytic site; other site
634458005549	DXD motif; other site
634458005550	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634458005551	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634458005552	active site
634458005553	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
634458005554	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634458005555	UDP-galactopyranose mutase; Region: GLF; pfam03275
634458005556	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
634458005557	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634458005558	active site
634458005559	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
634458005560	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634458005561	active site
634458005562	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458005563	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
634458005564	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634458005565	active site
634458005566	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
634458005567	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
634458005568	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
634458005569	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
634458005570	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
634458005571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
634458005572	Probable transposase; Region: OrfB_IS605; pfam01385
634458005573	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
634458005574	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
634458005575	Nitrogen regulatory protein P-II; Region: P-II; smart00938
634458005576	serine acetyltransferase; Provisional; Region: cysE; PRK11132
634458005577	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
634458005578	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
634458005579	trimer interface [polypeptide binding]; other site
634458005580	active site
634458005581	substrate binding site [chemical binding]; other site
634458005582	CoA binding site [chemical binding]; other site
634458005583	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634458005584	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
634458005585	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
634458005586	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
634458005587	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
634458005588	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
634458005589	DDE superfamily endonuclease; Region: DDE_5; cl17874
634458005590	elongation factor P; Validated; Region: PRK00529
634458005591	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
634458005592	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
634458005593	RNA binding site [nucleotide binding]; other site
634458005594	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
634458005595	RNA binding site [nucleotide binding]; other site
634458005596	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
634458005597	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
634458005598	active site
634458005599	dimerization interface [polypeptide binding]; other site
634458005600	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634458005601	ATP binding site [chemical binding]; other site
634458005602	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
634458005603	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
634458005604	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
634458005605	DNA-binding site [nucleotide binding]; DNA binding site
634458005606	RNA-binding motif; other site
634458005607	Dienelactone hydrolase family; Region: DLH; pfam01738
634458005608	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
634458005609	oligomerisation interface [polypeptide binding]; other site
634458005610	mobile loop; other site
634458005611	roof hairpin; other site
634458005612	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
634458005613	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
634458005614	ring oligomerisation interface [polypeptide binding]; other site
634458005615	ATP/Mg binding site [chemical binding]; other site
634458005616	stacking interactions; other site
634458005617	hinge regions; other site
634458005618	FkbH-like domain; Region: FkbH; TIGR01686
634458005619	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458005620	active site
634458005621	motif I; other site
634458005622	motif II; other site
634458005623	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634458005624	Transposase; Region: HTH_Tnp_1; pfam01527
634458005625	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634458005626	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634458005627	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634458005628	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634458005629	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634458005630	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634458005631	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634458005632	Transposase domain (DUF772); Region: DUF772; pfam05598
634458005633	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458005634	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634458005635	HTH-like domain; Region: HTH_21; pfam13276
634458005636	Integrase core domain; Region: rve; pfam00665
634458005637	Integrase core domain; Region: rve_3; pfam13683
634458005638	Transposase; Region: HTH_Tnp_1; pfam01527
634458005639	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458005640	Transposase domain (DUF772); Region: DUF772; pfam05598
634458005641	GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183
634458005642	Ligand binding site; other site
634458005643	Phosphotransferase enzyme family; Region: APH; pfam01636
634458005644	capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689
634458005645	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458005646	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458005647	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634458005648	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458005649	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
634458005650	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458005651	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
634458005652	GDP-Fucose binding site [chemical binding]; other site
634458005653	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
634458005654	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
634458005655	substrate binding site; other site
634458005656	tetramer interface; other site
634458005657	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
634458005658	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
634458005659	NAD binding site [chemical binding]; other site
634458005660	substrate binding site [chemical binding]; other site
634458005661	homodimer interface [polypeptide binding]; other site
634458005662	active site
634458005663	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458005664	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
634458005665	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458005666	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458005667	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458005668	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458005669	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458005670	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458005671	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458005672	Transposase domain (DUF772); Region: DUF772; pfam05598
634458005673	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458005674	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634458005675	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634458005676	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634458005677	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634458005678	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634458005679	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634458005680	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634458005681	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634458005682	Transposase; Region: HTH_Tnp_1; pfam01527
634458005683	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
634458005684	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
634458005685	active site
634458005686	catalytic triad [active]
634458005687	oxyanion hole [active]
634458005688	Glycosyltransferase family 17; Region: Glyco_transf_17; pfam04724
634458005689	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
634458005690	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
634458005691	Aspartyl protease; Region: Asp_protease_2; pfam13650
634458005692	inhibitor binding site; inhibition site
634458005693	catalytic motif [active]
634458005694	Catalytic residue [active]
634458005695	Active site flap [active]
634458005696	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
634458005697	inhibitor binding site; inhibition site
634458005698	catalytic motif [active]
634458005699	Catalytic residue [active]
634458005700	Active site flap [active]
634458005701	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
634458005702	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
634458005703	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458005704	active site
634458005705	DNA binding site [nucleotide binding]
634458005706	Int/Topo IB signature motif; other site
634458005707	primosome assembly protein PriA; Validated; Region: PRK05580
634458005708	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458005709	ATP binding site [chemical binding]; other site
634458005710	putative Mg++ binding site [ion binding]; other site
634458005711	Preprotein translocase subunit; Region: YajC; pfam02699
634458005712	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
634458005713	Protein of unknown function (DUF815); Region: DUF815; pfam05673
634458005714	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634458005715	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634458005716	[2Fe-2S] cluster binding site [ion binding]; other site
634458005717	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
634458005718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634458005719	Coenzyme A binding pocket [chemical binding]; other site
634458005720	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
634458005721	active site
634458005722	8-oxo-dGMP binding site [chemical binding]; other site
634458005723	nudix motif; other site
634458005724	metal binding site [ion binding]; metal-binding site
634458005725	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
634458005726	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
634458005727	Substrate binding site; other site
634458005728	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
634458005729	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
634458005730	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
634458005731	homodimer interface [polypeptide binding]; other site
634458005732	substrate-cofactor binding pocket; other site
634458005733	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458005734	catalytic residue [active]
634458005735	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
634458005736	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
634458005737	GTP cyclohydrolase I; Provisional; Region: PLN03044
634458005738	active site
634458005739	intracellular protease, PfpI family; Region: PfpI; TIGR01382
634458005740	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
634458005741	conserved cys residue [active]
634458005742	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
634458005743	MPT binding site; other site
634458005744	trimer interface [polypeptide binding]; other site
634458005745	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634458005746	Uncharacterized conserved protein [Function unknown]; Region: COG4717
634458005747	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
634458005748	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
634458005749	active site
634458005750	metal binding site [ion binding]; metal-binding site
634458005751	DNA binding site [nucleotide binding]
634458005752	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634458005753	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
634458005754	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
634458005755	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
634458005756	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458005757	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458005758	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
634458005759	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
634458005760	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
634458005761	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
634458005762	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
634458005763	homopentamer interface [polypeptide binding]; other site
634458005764	active site
634458005765	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
634458005766	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
634458005767	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
634458005768	dimerization interface [polypeptide binding]; other site
634458005769	active site
634458005770	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
634458005771	Lumazine binding domain; Region: Lum_binding; pfam00677
634458005772	Lumazine binding domain; Region: Lum_binding; pfam00677
634458005773	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
634458005774	catalytic motif [active]
634458005775	Zn binding site [ion binding]; other site
634458005776	RibD C-terminal domain; Region: RibD_C; cl17279
634458005777	cytochrome b; Provisional; Region: CYTB; MTH00145
634458005778	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
634458005779	Qi binding site; other site
634458005780	intrachain domain interface; other site
634458005781	interchain domain interface [polypeptide binding]; other site
634458005782	heme bH binding site [chemical binding]; other site
634458005783	heme bL binding site [chemical binding]; other site
634458005784	Qo binding site; other site
634458005785	interchain domain interface [polypeptide binding]; other site
634458005786	intrachain domain interface; other site
634458005787	Qi binding site; other site
634458005788	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
634458005789	Qo binding site; other site
634458005790	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
634458005791	Cytochrome c; Region: Cytochrom_C; cl11414
634458005792	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
634458005793	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
634458005794	[2Fe-2S] cluster binding site [ion binding]; other site
634458005795	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
634458005796	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
634458005797	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634458005798	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
634458005799	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634458005800	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634458005801	Hint domain; Region: Hint_2; pfam13403
634458005802	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458005803	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
634458005804	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458005805	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
634458005806	Predicted helicase [General function prediction only]; Region: COG4889
634458005807	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458005808	ATP binding site [chemical binding]; other site
634458005809	putative Mg++ binding site [ion binding]; other site
634458005810	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
634458005811	ATP-binding site [chemical binding]; other site
634458005812	Protein of unknown function DUF262; Region: DUF262; pfam03235
634458005813	Uncharacterized conserved protein [Function unknown]; Region: COG1479
634458005814	Protein of unknown function DUF262; Region: DUF262; pfam03235
634458005815	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
634458005816	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
634458005817	HTH-like domain; Region: HTH_21; pfam13276
634458005818	Integrase core domain; Region: rve; pfam00665
634458005819	Integrase core domain; Region: rve_3; pfam13683
634458005820	Transposase; Region: HTH_Tnp_1; pfam01527
634458005821	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
634458005822	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
634458005823	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
634458005824	GTPase CgtA; Reviewed; Region: obgE; PRK12299
634458005825	GTP1/OBG; Region: GTP1_OBG; pfam01018
634458005826	Obg GTPase; Region: Obg; cd01898
634458005827	G1 box; other site
634458005828	GTP/Mg2+ binding site [chemical binding]; other site
634458005829	Switch I region; other site
634458005830	G2 box; other site
634458005831	G3 box; other site
634458005832	Switch II region; other site
634458005833	G4 box; other site
634458005834	G5 box; other site
634458005835	gamma-glutamyl kinase; Provisional; Region: PRK05429
634458005836	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
634458005837	nucleotide binding site [chemical binding]; other site
634458005838	homotetrameric interface [polypeptide binding]; other site
634458005839	putative phosphate binding site [ion binding]; other site
634458005840	putative allosteric binding site; other site
634458005841	PUA domain; Region: PUA; pfam01472
634458005842	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
634458005843	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
634458005844	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
634458005845	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
634458005846	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634458005847	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634458005848	substrate binding pocket [chemical binding]; other site
634458005849	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
634458005850	cell division protein MraZ; Reviewed; Region: PRK00326
634458005851	MraZ protein; Region: MraZ; pfam02381
634458005852	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
634458005853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458005854	S-adenosylmethionine binding site [chemical binding]; other site
634458005855	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
634458005856	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
634458005857	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
634458005858	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
634458005859	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
634458005860	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634458005861	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634458005862	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634458005863	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
634458005864	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634458005865	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634458005866	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634458005867	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
634458005868	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
634458005869	Mg++ binding site [ion binding]; other site
634458005870	putative catalytic motif [active]
634458005871	putative substrate binding site [chemical binding]; other site
634458005872	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
634458005873	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634458005874	cell division protein FtsW; Region: ftsW; TIGR02614
634458005875	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
634458005876	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
634458005877	active site
634458005878	homodimer interface [polypeptide binding]; other site
634458005879	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
634458005880	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
634458005881	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634458005882	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
634458005883	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
634458005884	FAD binding domain; Region: FAD_binding_4; pfam01565
634458005885	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
634458005886	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
634458005887	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
634458005888	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634458005889	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
634458005890	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
634458005891	Cell division protein FtsQ; Region: FtsQ; pfam03799
634458005892	Cell division protein FtsA; Region: FtsA; smart00842
634458005893	cell division protein FtsA; Region: ftsA; TIGR01174
634458005894	Cell division protein FtsA; Region: FtsA; pfam14450
634458005895	cell division protein FtsZ; Validated; Region: PRK09330
634458005896	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
634458005897	nucleotide binding site [chemical binding]; other site
634458005898	SulA interaction site; other site
634458005899	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
634458005900	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
634458005901	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
634458005902	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
634458005903	binding surface
634458005904	TPR motif; other site
634458005905	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
634458005906	Walker A/P-loop; other site
634458005907	ATP binding site [chemical binding]; other site
634458005908	Q-loop/lid; other site
634458005909	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
634458005910	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
634458005911	ABC transporter signature motif; other site
634458005912	Walker B; other site
634458005913	D-loop; other site
634458005914	H-loop/switch region; other site
634458005915	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
634458005916	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
634458005917	nucleotide binding pocket [chemical binding]; other site
634458005918	K-X-D-G motif; other site
634458005919	catalytic site [active]
634458005920	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
634458005921	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
634458005922	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
634458005923	Dimer interface [polypeptide binding]; other site
634458005924	BRCT sequence motif; other site
634458005925	pyruvate phosphate dikinase; Provisional; Region: PRK09279
634458005926	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
634458005927	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
634458005928	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
634458005929	PEP synthetase regulatory protein; Provisional; Region: PRK05339
634458005930	Uncharacterized conserved protein [Function unknown]; Region: COG1739
634458005931	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
634458005932	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
634458005933	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
634458005934	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
634458005935	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
634458005936	active site
634458005937	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
634458005938	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634458005939	active site
634458005940	HIGH motif; other site
634458005941	nucleotide binding site [chemical binding]; other site
634458005942	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
634458005943	active site
634458005944	KMSKS motif; other site
634458005945	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
634458005946	Isochorismatase family; Region: Isochorismatase; pfam00857
634458005947	catalytic triad [active]
634458005948	metal binding site [ion binding]; metal-binding site
634458005949	conserved cis-peptide bond; other site
634458005950	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
634458005951	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634458005952	metal-binding site [ion binding]
634458005953	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
634458005954	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634458005955	metal-binding site [ion binding]
634458005956	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
634458005957	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458005958	motif II; other site
634458005959	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
634458005960	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
634458005961	Multicopper oxidase; Region: Cu-oxidase; pfam00394
634458005962	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
634458005963	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
634458005964	ketol-acid reductoisomerase; Provisional; Region: PRK05479
634458005965	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
634458005966	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
634458005967	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
634458005968	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
634458005969	putative valine binding site [chemical binding]; other site
634458005970	dimer interface [polypeptide binding]; other site
634458005971	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
634458005972	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
634458005973	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
634458005974	PYR/PP interface [polypeptide binding]; other site
634458005975	dimer interface [polypeptide binding]; other site
634458005976	TPP binding site [chemical binding]; other site
634458005977	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634458005978	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
634458005979	TPP-binding site [chemical binding]; other site
634458005980	dimer interface [polypeptide binding]; other site
634458005981	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
634458005982	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
634458005983	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
634458005984	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458005985	motif II; other site
634458005986	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
634458005987	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
634458005988	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634458005989	ATP binding site [chemical binding]; other site
634458005990	putative Mg++ binding site [ion binding]; other site
634458005991	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458005992	nucleotide binding region [chemical binding]; other site
634458005993	ATP-binding site [chemical binding]; other site
634458005994	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458005995	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634458005996	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458005997	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634458005998	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
634458005999	active site
634458006000	Zn binding site [ion binding]; other site
634458006001	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
634458006002	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
634458006003	dimer interface [polypeptide binding]; other site
634458006004	active site
634458006005	glycine-pyridoxal phosphate binding site [chemical binding]; other site
634458006006	folate binding site [chemical binding]; other site
634458006007	amino acid transporter; Region: 2A0306; TIGR00909
634458006008	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
634458006009	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
634458006010	dimer interface [polypeptide binding]; other site
634458006011	allosteric magnesium binding site [ion binding]; other site
634458006012	active site
634458006013	aspartate-rich active site metal binding site; other site
634458006014	Schiff base residues; other site
634458006015	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
634458006016	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
634458006017	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
634458006018	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
634458006019	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
634458006020	CAP-like domain; other site
634458006021	active site
634458006022	primary dimer interface [polypeptide binding]; other site
634458006023	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
634458006024	Recombination protein O N terminal; Region: RecO_N; pfam11967
634458006025	Recombination protein O C terminal; Region: RecO_C; pfam02565
634458006026	elongation factor Ts; Provisional; Region: tsf; PRK09377
634458006027	UBA/TS-N domain; Region: UBA; pfam00627
634458006028	Elongation factor TS; Region: EF_TS; pfam00889
634458006029	Elongation factor TS; Region: EF_TS; pfam00889
634458006030	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
634458006031	rRNA interaction site [nucleotide binding]; other site
634458006032	S8 interaction site; other site
634458006033	putative laminin-1 binding site; other site
634458006034	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634458006035	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634458006036	[2Fe-2S] cluster binding site [ion binding]; other site
634458006037	Selenoprotein P, N terminal region; Region: SelP_N; pfam04592
634458006038	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
634458006039	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
634458006040	homodimer interface [polypeptide binding]; other site
634458006041	substrate-cofactor binding pocket; other site
634458006042	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458006043	catalytic residue [active]
634458006044	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
634458006045	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
634458006046	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
634458006047	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
634458006048	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
634458006049	putative active site [active]
634458006050	putative PHP Thumb interface [polypeptide binding]; other site
634458006051	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
634458006052	generic binding surface II; other site
634458006053	generic binding surface I; other site
634458006054	Pantoate-beta-alanine ligase; Region: PanC; cd00560
634458006055	pantoate--beta-alanine ligase; Region: panC; TIGR00018
634458006056	active site
634458006057	ATP-binding site [chemical binding]; other site
634458006058	pantoate-binding site; other site
634458006059	HXXH motif; other site
634458006060	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
634458006061	homotrimer interaction site [polypeptide binding]; other site
634458006062	putative active site [active]
634458006063	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
634458006064	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
634458006065	aspartate aminotransferase; Provisional; Region: PRK05764
634458006066	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458006067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458006068	homodimer interface [polypeptide binding]; other site
634458006069	catalytic residue [active]
634458006070	aspartate aminotransferase; Provisional; Region: PRK05764
634458006071	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458006072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458006073	homodimer interface [polypeptide binding]; other site
634458006074	catalytic residue [active]
634458006075	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
634458006076	active site
634458006077	HIGH motif; other site
634458006078	nucleotide binding site [chemical binding]; other site
634458006079	active site
634458006080	KMSKS motif; other site
634458006081	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
634458006082	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
634458006083	active site
634458006084	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
634458006085	metal-binding site [ion binding]
634458006086	hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367
634458006087	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
634458006088	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458006089	FeS/SAM binding site; other site
634458006090	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
634458006091	active site
634458006092	multimer interface [polypeptide binding]; other site
634458006093	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
634458006094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458006095	Walker A/P-loop; other site
634458006096	ATP binding site [chemical binding]; other site
634458006097	Q-loop/lid; other site
634458006098	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634458006099	ABC transporter; Region: ABC_tran_2; pfam12848
634458006100	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
634458006101	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
634458006102	Domain of unknown function DUF20; Region: UPF0118; pfam01594
634458006103	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634458006104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458006105	active site
634458006106	phosphorylation site [posttranslational modification]
634458006107	intermolecular recognition site; other site
634458006108	dimerization interface [polypeptide binding]; other site
634458006109	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458006110	DNA binding site [nucleotide binding]
634458006111	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634458006112	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
634458006113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
634458006114	dimer interface [polypeptide binding]; other site
634458006115	phosphorylation site [posttranslational modification]
634458006116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458006117	ATP binding site [chemical binding]; other site
634458006118	Mg2+ binding site [ion binding]; other site
634458006119	G-X-G motif; other site
634458006120	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
634458006121	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
634458006122	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
634458006123	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
634458006124	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
634458006125	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
634458006126	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
634458006127	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
634458006128	active site
634458006129	dimer interface [polypeptide binding]; other site
634458006130	motif 1; other site
634458006131	motif 2; other site
634458006132	motif 3; other site
634458006133	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
634458006134	anticodon binding site; other site
634458006135	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
634458006136	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
634458006137	putative active site [active]
634458006138	TPR repeat; Region: TPR_11; pfam13414
634458006139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
634458006140	binding surface
634458006141	TPR motif; other site
634458006142	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458006143	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
634458006144	putative ADP-binding pocket [chemical binding]; other site
634458006145	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
634458006146	ATP-NAD kinase; Region: NAD_kinase; pfam01513
634458006147	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
634458006148	RNA/DNA hybrid binding site [nucleotide binding]; other site
634458006149	active site
634458006150	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
634458006151	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
634458006152	putative active site [active]
634458006153	putative substrate binding site [chemical binding]; other site
634458006154	ATP binding site [chemical binding]; other site
634458006155	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
634458006156	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
634458006157	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
634458006158	ABC1 family; Region: ABC1; cl17513
634458006159	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
634458006160	active site
634458006161	substrate binding site [chemical binding]; other site
634458006162	ATP binding site [chemical binding]; other site
634458006163	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
634458006164	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
634458006165	active site
634458006166	Zn binding site [ion binding]; other site
634458006167	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
634458006168	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
634458006169	active site
634458006170	dimer interface [polypeptide binding]; other site
634458006171	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
634458006172	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
634458006173	active site
634458006174	FMN binding site [chemical binding]; other site
634458006175	substrate binding site [chemical binding]; other site
634458006176	3Fe-4S cluster binding site [ion binding]; other site
634458006177	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
634458006178	domain interface; other site
634458006179	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
634458006180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634458006181	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634458006182	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
634458006183	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
634458006184	putative NAD(P) binding site [chemical binding]; other site
634458006185	active site
634458006186	EamA-like transporter family; Region: EamA; pfam00892
634458006187	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634458006188	EamA-like transporter family; Region: EamA; pfam00892
634458006189	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
634458006190	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
634458006191	active site
634458006192	metal binding site [ion binding]; metal-binding site
634458006193	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
634458006194	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
634458006195	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
634458006196	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
634458006197	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
634458006198	histidinol dehydrogenase; Region: hisD; TIGR00069
634458006199	NAD binding site [chemical binding]; other site
634458006200	dimerization interface [polypeptide binding]; other site
634458006201	product binding site; other site
634458006202	substrate binding site [chemical binding]; other site
634458006203	zinc binding site [ion binding]; other site
634458006204	catalytic residues [active]
634458006205	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
634458006206	rRNA binding site [nucleotide binding]; other site
634458006207	predicted 30S ribosome binding site; other site
634458006208	Maf-like protein; Region: Maf; pfam02545
634458006209	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
634458006210	active site
634458006211	dimer interface [polypeptide binding]; other site
634458006212	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
634458006213	RNA binding site [nucleotide binding]; other site
634458006214	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
634458006215	Domain of unknown function (DUF329); Region: DUF329; pfam03884
634458006216	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
634458006217	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
634458006218	catalytic residue [active]
634458006219	protease 2; Provisional; Region: PRK10115
634458006220	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
634458006221	Phage capsid family; Region: Phage_capsid; pfam05065
634458006222	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
634458006223	Phage-related protein [Function unknown]; Region: COG4695
634458006224	Phage portal protein; Region: Phage_portal; pfam04860
634458006225	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
634458006226	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
634458006227	active site
634458006228	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
634458006229	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
634458006230	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458006231	active site
634458006232	DNA binding site [nucleotide binding]
634458006233	Int/Topo IB signature motif; other site
634458006234	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
634458006235	Prophage antirepressor [Transcription]; Region: COG3617
634458006236	BRO family, N-terminal domain; Region: Bro-N; smart01040
634458006237	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
634458006238	Predicted transcriptional regulator [Transcription]; Region: COG2932
634458006239	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
634458006240	Catalytic site [active]
634458006241	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
634458006242	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
634458006243	active site
634458006244	catalytic site [active]
634458006245	substrate binding site [chemical binding]; other site
634458006246	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458006247	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634458006248	non-specific DNA binding site [nucleotide binding]; other site
634458006249	salt bridge; other site
634458006250	sequence-specific DNA binding site [nucleotide binding]; other site
634458006251	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
634458006252	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458006253	active site
634458006254	DNA binding site [nucleotide binding]
634458006255	Int/Topo IB signature motif; other site
634458006256	Cytochrome c; Region: Cytochrom_C; pfam00034
634458006257	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
634458006258	homotetramer interface [polypeptide binding]; other site
634458006259	short chain dehydrogenase; Validated; Region: PRK07069
634458006260	NAD binding site [chemical binding]; other site
634458006261	homodimer interface [polypeptide binding]; other site
634458006262	active site
634458006263	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
634458006264	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634458006265	NAD binding site [chemical binding]; other site
634458006266	catalytic residues [active]
634458006267	D-lactate dehydrogenase; Provisional; Region: PRK11183
634458006268	FAD binding domain; Region: FAD_binding_4; pfam01565
634458006269	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
634458006270	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
634458006271	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
634458006272	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
634458006273	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
634458006274	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
634458006275	Uncharacterized conserved protein [Function unknown]; Region: COG2308
634458006276	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
634458006277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
634458006278	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
634458006279	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
634458006280	dimerization interface [polypeptide binding]; other site
634458006281	active site
634458006282	quinolinate synthetase; Provisional; Region: PRK09375
634458006283	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
634458006284	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458006285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458006286	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
634458006287	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
634458006288	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634458006289	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
634458006290	NAD(P) binding site [chemical binding]; other site
634458006291	catalytic residues [active]
634458006292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458006293	Major Facilitator Superfamily; Region: MFS_1; pfam07690
634458006294	putative substrate translocation pore; other site
634458006295	Domain of unknown function (DUF336); Region: DUF336; pfam03928
634458006296	Predicted flavoprotein [General function prediction only]; Region: COG0431
634458006297	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
634458006298	Pirin-related protein [General function prediction only]; Region: COG1741
634458006299	Pirin; Region: Pirin; pfam02678
634458006300	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
634458006301	LysR family transcriptional regulator; Provisional; Region: PRK14997
634458006302	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458006303	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
634458006304	putative effector binding pocket; other site
634458006305	putative dimerization interface [polypeptide binding]; other site
634458006306	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634458006307	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634458006308	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634458006309	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
634458006310	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
634458006311	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634458006312	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458006313	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
634458006314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458006315	D-galactonate transporter; Region: 2A0114; TIGR00893
634458006316	putative substrate translocation pore; other site
634458006317	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
634458006318	EamA-like transporter family; Region: EamA; cl17759
634458006319	EamA-like transporter family; Region: EamA; pfam00892
634458006320	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
634458006321	putative active site [active]
634458006322	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
634458006323	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
634458006324	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
634458006325	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
634458006326	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458006327	NAD(P) binding site [chemical binding]; other site
634458006328	active site
634458006329	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
634458006330	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634458006331	carboxyltransferase (CT) interaction site; other site
634458006332	biotinylation site [posttranslational modification]; other site
634458006333	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
634458006334	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634458006335	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
634458006336	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
634458006337	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
634458006338	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634458006339	carboxyltransferase (CT) interaction site; other site
634458006340	biotinylation site [posttranslational modification]; other site
634458006341	aspartate aminotransferase; Provisional; Region: PRK05764
634458006342	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458006343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458006344	homodimer interface [polypeptide binding]; other site
634458006345	catalytic residue [active]
634458006346	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
634458006347	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458006348	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
634458006349	putative dimerization interface [polypeptide binding]; other site
634458006350	amidase; Provisional; Region: PRK07056
634458006351	Amidase; Region: Amidase; cl11426
634458006352	short chain dehydrogenase; Provisional; Region: PRK09291
634458006353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458006354	NAD(P) binding site [chemical binding]; other site
634458006355	active site
634458006356	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
634458006357	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
634458006358	active site
634458006359	catalytic site [active]
634458006360	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
634458006361	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
634458006362	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
634458006363	catalytic site [active]
634458006364	active site
634458006365	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
634458006366	glycogen branching enzyme; Provisional; Region: PRK05402
634458006367	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
634458006368	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
634458006369	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
634458006370	active site
634458006371	catalytic site [active]
634458006372	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
634458006373	glycogen synthase; Provisional; Region: glgA; PRK00654
634458006374	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
634458006375	ADP-binding pocket [chemical binding]; other site
634458006376	homodimer interface [polypeptide binding]; other site
634458006377	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
634458006378	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
634458006379	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
634458006380	active site
634458006381	catalytic site [active]
634458006382	short chain dehydrogenase; Provisional; Region: PRK06701
634458006383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458006384	NAD(P) binding site [chemical binding]; other site
634458006385	active site
634458006386	thiamine pyrophosphate protein; Provisional; Region: PRK08273
634458006387	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
634458006388	PYR/PP interface [polypeptide binding]; other site
634458006389	dimer interface [polypeptide binding]; other site
634458006390	tetramer interface [polypeptide binding]; other site
634458006391	TPP binding site [chemical binding]; other site
634458006392	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634458006393	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
634458006394	TPP-binding site [chemical binding]; other site
634458006395	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634458006396	Transposase; Region: HTH_Tnp_1; pfam01527
634458006397	HTH-like domain; Region: HTH_21; pfam13276
634458006398	Integrase core domain; Region: rve; pfam00665
634458006399	Integrase core domain; Region: rve_3; pfam13683
634458006400	FAD binding domain; Region: FAD_binding_3; pfam01494
634458006401	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634458006402	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
634458006403	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
634458006404	Cu(I) binding site [ion binding]; other site
634458006405	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458006406	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634458006407	N-terminal plug; other site
634458006408	ligand-binding site [chemical binding]; other site
634458006409	Hint domain; Region: Hint_2; pfam13403
634458006410	HTH-like domain; Region: HTH_21; pfam13276
634458006411	Integrase core domain; Region: rve; pfam00665
634458006412	Integrase core domain; Region: rve_3; pfam13683
634458006413	Transposase; Region: HTH_Tnp_1; pfam01527
634458006414	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
634458006415	nudix motif; other site
634458006416	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458006417	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
634458006418	dimerization interface [polypeptide binding]; other site
634458006419	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634458006420	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634458006421	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
634458006422	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
634458006423	Zinc-finger domain; Region: zf-CHCC; pfam10276
634458006424	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
634458006425	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
634458006426	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
634458006427	DsbD alpha interface [polypeptide binding]; other site
634458006428	catalytic residues [active]
634458006429	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
634458006430	seryl-tRNA synthetase; Provisional; Region: PRK05431
634458006431	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
634458006432	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
634458006433	dimer interface [polypeptide binding]; other site
634458006434	active site
634458006435	motif 1; other site
634458006436	motif 2; other site
634458006437	motif 3; other site
634458006438	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
634458006439	sec-independent translocase; Provisional; Region: tatB; PRK00182
634458006440	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
634458006441	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
634458006442	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
634458006443	Sporulation related domain; Region: SPOR; pfam05036
634458006444	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
634458006445	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
634458006446	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634458006447	active site
634458006448	HIGH motif; other site
634458006449	nucleotide binding site [chemical binding]; other site
634458006450	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
634458006451	KMSK motif region; other site
634458006452	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
634458006453	tRNA binding surface [nucleotide binding]; other site
634458006454	anticodon binding site; other site
634458006455	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
634458006456	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
634458006457	Zn2+ binding site [ion binding]; other site
634458006458	Mg2+ binding site [ion binding]; other site
634458006459	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
634458006460	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
634458006461	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
634458006462	putative catalytic site [active]
634458006463	putative phosphate binding site [ion binding]; other site
634458006464	active site
634458006465	metal binding site A [ion binding]; metal-binding site
634458006466	DNA binding site [nucleotide binding]
634458006467	putative AP binding site [nucleotide binding]; other site
634458006468	putative metal binding site B [ion binding]; other site
634458006469	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634458006470	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634458006471	active site
634458006472	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
634458006473	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
634458006474	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
634458006475	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
634458006476	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
634458006477	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
634458006478	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
634458006479	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
634458006480	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
634458006481	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
634458006482	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458006483	FeS/SAM binding site; other site
634458006484	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
634458006485	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
634458006486	dinuclear metal binding motif [ion binding]; other site
634458006487	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
634458006488	Clp protease; Region: CLP_protease; pfam00574
634458006489	oligomer interface [polypeptide binding]; other site
634458006490	active site residues [active]
634458006491	aminotransferase; Validated; Region: PRK09148
634458006492	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458006493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458006494	homodimer interface [polypeptide binding]; other site
634458006495	catalytic residue [active]
634458006496	homoserine dehydrogenase; Provisional; Region: PRK06349
634458006497	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
634458006498	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
634458006499	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
634458006500	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
634458006501	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
634458006502	putative active site [active]
634458006503	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
634458006504	DHH family; Region: DHH; pfam01368
634458006505	DHHA1 domain; Region: DHHA1; pfam02272
634458006506	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
634458006507	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
634458006508	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
634458006509	DNA binding residues [nucleotide binding]
634458006510	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634458006511	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634458006512	RNA binding surface [nucleotide binding]; other site
634458006513	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634458006514	active site
634458006515	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
634458006516	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
634458006517	ABC-ATPase subunit  interface; other site
634458006518	dimer interface [polypeptide binding]; other site
634458006519	putative PBP binding regions; other site
634458006520	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
634458006521	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
634458006522	Walker A/P-loop; other site
634458006523	ATP binding site [chemical binding]; other site
634458006524	Q-loop/lid; other site
634458006525	ABC transporter signature motif; other site
634458006526	Walker B; other site
634458006527	D-loop; other site
634458006528	H-loop/switch region; other site
634458006529	Uncharacterized conserved protein [Function unknown]; Region: COG0397
634458006530	hypothetical protein; Validated; Region: PRK00029
634458006531	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
634458006532	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
634458006533	homodimer interface [polypeptide binding]; other site
634458006534	substrate-cofactor binding pocket; other site
634458006535	catalytic residue [active]
634458006536	DNA polymerase I; Provisional; Region: PRK05755
634458006537	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
634458006538	active site
634458006539	metal binding site 1 [ion binding]; metal-binding site
634458006540	putative 5' ssDNA interaction site; other site
634458006541	metal binding site 3; metal-binding site
634458006542	metal binding site 2 [ion binding]; metal-binding site
634458006543	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
634458006544	putative DNA binding site [nucleotide binding]; other site
634458006545	putative metal binding site [ion binding]; other site
634458006546	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
634458006547	active site
634458006548	catalytic site [active]
634458006549	substrate binding site [chemical binding]; other site
634458006550	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
634458006551	active site
634458006552	DNA binding site [nucleotide binding]
634458006553	catalytic site [active]
634458006554	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
634458006555	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
634458006556	Cu(I) binding site [ion binding]; other site
634458006557	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
634458006558	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
634458006559	putative acyl-acceptor binding pocket; other site
634458006560	proline/glycine betaine transporter; Provisional; Region: PRK10642
634458006561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458006562	putative substrate translocation pore; other site
634458006563	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458006564	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458006565	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
634458006566	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
634458006567	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
634458006568	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
634458006569	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
634458006570	L-asparagine permease; Provisional; Region: PRK15049
634458006571	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
634458006572	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
634458006573	Trp docking motif [polypeptide binding]; other site
634458006574	putative active site [active]
634458006575	Hint domain; Region: Hint_2; pfam13403
634458006576	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
634458006577	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
634458006578	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634458006579	inhibitor-cofactor binding pocket; inhibition site
634458006580	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458006581	catalytic residue [active]
634458006582	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
634458006583	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
634458006584	DNA-binding site [nucleotide binding]; DNA binding site
634458006585	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458006586	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458006587	homodimer interface [polypeptide binding]; other site
634458006588	catalytic residue [active]
634458006589	allantoate amidohydrolase; Reviewed; Region: PRK09290
634458006590	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
634458006591	active site
634458006592	metal binding site [ion binding]; metal-binding site
634458006593	dimer interface [polypeptide binding]; other site
634458006594	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
634458006595	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
634458006596	homodimer interface [polypeptide binding]; other site
634458006597	active site
634458006598	FMN binding site [chemical binding]; other site
634458006599	substrate binding site [chemical binding]; other site
634458006600	4Fe-4S binding domain; Region: Fer4; pfam00037
634458006601	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
634458006602	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
634458006603	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
634458006604	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
634458006605	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634458006606	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
634458006607	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
634458006608	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
634458006609	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
634458006610	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
634458006611	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
634458006612	Transposase; Region: HTH_Tnp_1; pfam01527
634458006613	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458006614	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
634458006615	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
634458006616	phenylhydantoinase; Validated; Region: PRK08323
634458006617	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
634458006618	tetramer interface [polypeptide binding]; other site
634458006619	active site
634458006620	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634458006621	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
634458006622	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
634458006623	putative substrate binding site [chemical binding]; other site
634458006624	Na binding site [ion binding]; other site
634458006625	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458006626	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
634458006627	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
634458006628	active site
634458006629	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
634458006630	active site
634458006631	dimer interface [polypeptide binding]; other site
634458006632	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
634458006633	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458006634	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
634458006635	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
634458006636	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
634458006637	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
634458006638	active site
634458006639	hydrophilic channel; other site
634458006640	catalytic residues [active]
634458006641	active site lid [active]
634458006642	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
634458006643	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
634458006644	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
634458006645	Na binding site [ion binding]; other site
634458006646	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
634458006647	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
634458006648	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
634458006649	Beta-lactamase; Region: Beta-lactamase; pfam00144
634458006650	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
634458006651	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458006652	non-specific DNA binding site [nucleotide binding]; other site
634458006653	salt bridge; other site
634458006654	sequence-specific DNA binding site [nucleotide binding]; other site
634458006655	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
634458006656	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
634458006657	heme-binding site [chemical binding]; other site
634458006658	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
634458006659	FAD binding pocket [chemical binding]; other site
634458006660	FAD binding motif [chemical binding]; other site
634458006661	phosphate binding motif [ion binding]; other site
634458006662	beta-alpha-beta structure motif; other site
634458006663	NAD binding pocket [chemical binding]; other site
634458006664	Heme binding  pocket [chemical binding]; other site
634458006665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458006666	dimer interface [polypeptide binding]; other site
634458006667	conserved gate region; other site
634458006668	putative PBP binding loops; other site
634458006669	ABC-ATPase subunit interface; other site
634458006670	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
634458006671	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
634458006672	Walker A/P-loop; other site
634458006673	ATP binding site [chemical binding]; other site
634458006674	Q-loop/lid; other site
634458006675	ABC transporter signature motif; other site
634458006676	Walker B; other site
634458006677	D-loop; other site
634458006678	H-loop/switch region; other site
634458006679	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
634458006680	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
634458006681	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
634458006682	FAD binding domain; Region: FAD_binding_4; pfam01565
634458006683	siroheme synthase; Provisional; Region: cysG; PRK10637
634458006684	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
634458006685	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
634458006686	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
634458006687	active site
634458006688	SAM binding site [chemical binding]; other site
634458006689	homodimer interface [polypeptide binding]; other site
634458006690	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
634458006691	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
634458006692	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634458006693	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
634458006694	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
634458006695	Amidase; Region: Amidase; cl11426
634458006696	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
634458006697	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
634458006698	intersubunit interface [polypeptide binding]; other site
634458006699	active site
634458006700	Zn2+ binding site [ion binding]; other site
634458006701	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
634458006702	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
634458006703	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
634458006704	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
634458006705	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
634458006706	FMN-binding pocket [chemical binding]; other site
634458006707	flavin binding motif; other site
634458006708	phosphate binding motif [ion binding]; other site
634458006709	beta-alpha-beta structure motif; other site
634458006710	NAD binding pocket [chemical binding]; other site
634458006711	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634458006712	catalytic loop [active]
634458006713	iron binding site [ion binding]; other site
634458006714	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
634458006715	classical (c) SDRs; Region: SDR_c; cd05233
634458006716	NAD(P) binding site [chemical binding]; other site
634458006717	active site
634458006718	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
634458006719	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634458006720	[2Fe-2S] cluster binding site [ion binding]; other site
634458006721	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
634458006722	putative alpha subunit interface [polypeptide binding]; other site
634458006723	putative active site [active]
634458006724	putative substrate binding site [chemical binding]; other site
634458006725	Fe binding site [ion binding]; other site
634458006726	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
634458006727	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
634458006728	active site
634458006729	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
634458006730	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
634458006731	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634458006732	NAD(P) binding site [chemical binding]; other site
634458006733	catalytic residues [active]
634458006734	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
634458006735	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
634458006736	Trp docking motif [polypeptide binding]; other site
634458006737	cytochrome domain interface [polypeptide binding]; other site
634458006738	active site
634458006739	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634458006740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458006741	putative substrate translocation pore; other site
634458006742	SnoaL-like domain; Region: SnoaL_4; pfam13577
634458006743	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458006744	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458006745	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
634458006746	putative substrate binding pocket [chemical binding]; other site
634458006747	dimerization interface [polypeptide binding]; other site
634458006748	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
634458006749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458006750	dimer interface [polypeptide binding]; other site
634458006751	conserved gate region; other site
634458006752	putative PBP binding loops; other site
634458006753	ABC-ATPase subunit interface; other site
634458006754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458006755	ABC-ATPase subunit interface; other site
634458006756	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458006757	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458006758	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458006759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
634458006760	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
634458006761	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
634458006762	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
634458006763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458006764	Walker A/P-loop; other site
634458006765	ATP binding site [chemical binding]; other site
634458006766	Q-loop/lid; other site
634458006767	ABC transporter signature motif; other site
634458006768	Walker B; other site
634458006769	D-loop; other site
634458006770	H-loop/switch region; other site
634458006771	TOBE domain; Region: TOBE_2; pfam08402
634458006772	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
634458006773	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
634458006774	tetrameric interface [polypeptide binding]; other site
634458006775	NAD binding site [chemical binding]; other site
634458006776	catalytic residues [active]
634458006777	substrate binding site [chemical binding]; other site
634458006778	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
634458006779	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
634458006780	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
634458006781	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
634458006782	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634458006783	Sel1-like repeats; Region: SEL1; smart00671
634458006784	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
634458006785	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
634458006786	N-terminal plug; other site
634458006787	ligand-binding site [chemical binding]; other site
634458006788	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
634458006789	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634458006790	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
634458006791	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
634458006792	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
634458006793	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458006794	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458006795	LysR substrate binding domain; Region: LysR_substrate; pfam03466
634458006796	dimerization interface [polypeptide binding]; other site
634458006797	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
634458006798	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
634458006799	[2Fe-2S] cluster binding site [ion binding]; other site
634458006800	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
634458006801	hydrophobic ligand binding site; other site
634458006802	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
634458006803	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
634458006804	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634458006805	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
634458006806	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
634458006807	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
634458006808	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
634458006809	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634458006810	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
634458006811	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
634458006812	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
634458006813	tetramerization interface [polypeptide binding]; other site
634458006814	NAD(P) binding site [chemical binding]; other site
634458006815	catalytic residues [active]
634458006816	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
634458006817	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458006818	putative substrate translocation pore; other site
634458006819	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
634458006820	homotrimer interface [polypeptide binding]; other site
634458006821	Walker A motif; other site
634458006822	GTP binding site [chemical binding]; other site
634458006823	Walker B motif; other site
634458006824	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
634458006825	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
634458006826	putative dimer interface [polypeptide binding]; other site
634458006827	active site pocket [active]
634458006828	putative cataytic base [active]
634458006829	cobalamin synthase; Reviewed; Region: cobS; PRK00235
634458006830	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
634458006831	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458006832	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458006833	homodimer interface [polypeptide binding]; other site
634458006834	catalytic residue [active]
634458006835	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
634458006836	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
634458006837	putative FMN binding site [chemical binding]; other site
634458006838	cobyric acid synthase; Provisional; Region: PRK00784
634458006839	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
634458006840	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
634458006841	catalytic triad [active]
634458006842	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
634458006843	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
634458006844	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
634458006845	homodimer interface [polypeptide binding]; other site
634458006846	Walker A motif; other site
634458006847	ATP binding site [chemical binding]; other site
634458006848	hydroxycobalamin binding site [chemical binding]; other site
634458006849	Walker B motif; other site
634458006850	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634458006851	catalytic core [active]
634458006852	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
634458006853	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634458006854	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634458006855	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
634458006856	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
634458006857	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
634458006858	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
634458006859	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
634458006860	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
634458006861	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
634458006862	dimer interface [polypeptide binding]; other site
634458006863	[2Fe-2S] cluster binding site [ion binding]; other site
634458006864	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
634458006865	MarR family; Region: MarR; pfam01047
634458006866	Fusaric acid resistance protein family; Region: FUSC; pfam04632
634458006867	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
634458006868	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
634458006869	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
634458006870	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
634458006871	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
634458006872	substrate binding site [chemical binding]; other site
634458006873	oxyanion hole (OAH) forming residues; other site
634458006874	trimer interface [polypeptide binding]; other site
634458006875	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
634458006876	Flavin Reductases; Region: FlaRed; cl00801
634458006877	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
634458006878	dimer interface [polypeptide binding]; other site
634458006879	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
634458006880	putative PBP binding regions; other site
634458006881	ABC-ATPase subunit  interface; other site
634458006882	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
634458006883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458006884	Walker A/P-loop; other site
634458006885	ATP binding site [chemical binding]; other site
634458006886	Q-loop/lid; other site
634458006887	ABC transporter signature motif; other site
634458006888	Walker B; other site
634458006889	D-loop; other site
634458006890	H-loop/switch region; other site
634458006891	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634458006892	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
634458006893	intersubunit interface [polypeptide binding]; other site
634458006894	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
634458006895	metal binding site 2 [ion binding]; metal-binding site
634458006896	putative DNA binding helix; other site
634458006897	metal binding site 1 [ion binding]; metal-binding site
634458006898	dimer interface [polypeptide binding]; other site
634458006899	structural Zn2+ binding site [ion binding]; other site
634458006900	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
634458006901	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
634458006902	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
634458006903	putative deacylase active site [active]
634458006904	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030
634458006905	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
634458006906	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
634458006907	dimer interface [polypeptide binding]; other site
634458006908	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458006909	catalytic residue [active]
634458006910	GMP synthase; Reviewed; Region: guaA; PRK00074
634458006911	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
634458006912	AMP/PPi binding site [chemical binding]; other site
634458006913	candidate oxyanion hole; other site
634458006914	catalytic triad [active]
634458006915	potential glutamine specificity residues [chemical binding]; other site
634458006916	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
634458006917	ATP Binding subdomain [chemical binding]; other site
634458006918	Ligand Binding sites [chemical binding]; other site
634458006919	Dimerization subdomain; other site
634458006920	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634458006921	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458006922	catalytic residues [active]
634458006923	catalytic nucleophile [active]
634458006924	Presynaptic Site I dimer interface [polypeptide binding]; other site
634458006925	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634458006926	Synaptic Flat tetramer interface [polypeptide binding]; other site
634458006927	Synaptic Site I dimer interface [polypeptide binding]; other site
634458006928	DNA binding site [nucleotide binding]
634458006929	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458006930	DNA-binding interface [nucleotide binding]; DNA binding site
634458006931	Domain of unknown function (DUF927); Region: DUF927; pfam06048
634458006932	Toprim domain; Region: Toprim_3; pfam13362
634458006933	Helix-turn-helix domain; Region: HTH_17; pfam12728
634458006934	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458006935	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458006936	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458006937	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458006938	salt bridge; other site
634458006939	non-specific DNA binding site [nucleotide binding]; other site
634458006940	sequence-specific DNA binding site [nucleotide binding]; other site
634458006941	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458006942	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458006943	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
634458006944	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
634458006945	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
634458006946	DNA binding residues [nucleotide binding]
634458006947	HNH endonuclease; Region: HNH_2; pfam13391
634458006948	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
634458006949	active site
634458006950	DNA binding site [nucleotide binding]
634458006951	Int/Topo IB signature motif; other site
634458006952	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634458006953	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458006954	putative substrate translocation pore; other site
634458006955	Phage shock protein B; Region: PspB; cl05946
634458006956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458006957	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634458006958	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634458006959	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634458006960	catalytic residue [active]
634458006961	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
634458006962	L-lactate permease; Region: Lactate_perm; cl00701
634458006963	Uncharacterized conserved protein [Function unknown]; Region: COG1359
634458006964	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
634458006965	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
634458006966	NADP binding site [chemical binding]; other site
634458006967	homopentamer interface [polypeptide binding]; other site
634458006968	substrate binding site [chemical binding]; other site
634458006969	active site
634458006970	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
634458006971	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
634458006972	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
634458006973	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
634458006974	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634458006975	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634458006976	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634458006977	catalytic residue [active]
634458006978	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
634458006979	Sporulation related domain; Region: SPOR; pfam05036
634458006980	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
634458006981	ABC-2 type transporter; Region: ABC2_membrane; cl17235
634458006982	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
634458006983	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
634458006984	Walker A/P-loop; other site
634458006985	ATP binding site [chemical binding]; other site
634458006986	Q-loop/lid; other site
634458006987	ABC transporter signature motif; other site
634458006988	Walker B; other site
634458006989	D-loop; other site
634458006990	H-loop/switch region; other site
634458006991	Uncharacterized conserved protein [Function unknown]; Region: COG1742
634458006992	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
634458006993	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
634458006994	Cl binding site [ion binding]; other site
634458006995	oligomer interface [polypeptide binding]; other site
634458006996	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
634458006997	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
634458006998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458006999	homodimer interface [polypeptide binding]; other site
634458007000	catalytic residue [active]
634458007001	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634458007002	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
634458007003	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
634458007004	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
634458007005	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
634458007006	TPP-binding site [chemical binding]; other site
634458007007	dimer interface [polypeptide binding]; other site
634458007008	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
634458007009	PYR/PP interface [polypeptide binding]; other site
634458007010	dimer interface [polypeptide binding]; other site
634458007011	TPP binding site [chemical binding]; other site
634458007012	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
634458007013	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
634458007014	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
634458007015	putative active site [active]
634458007016	catalytic residue [active]
634458007017	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
634458007018	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
634458007019	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
634458007020	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
634458007021	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458007022	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
634458007023	active site
634458007024	motif I; other site
634458007025	motif II; other site
634458007026	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
634458007027	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
634458007028	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
634458007029	putative active site [active]
634458007030	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
634458007031	tetramer (dimer of dimers) interface [polypeptide binding]; other site
634458007032	active site
634458007033	dimer interface [polypeptide binding]; other site
634458007034	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
634458007035	AAA domain; Region: AAA_33; pfam13671
634458007036	ATP-binding site [chemical binding]; other site
634458007037	Gluconate-6-phosphate binding site [chemical binding]; other site
634458007038	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
634458007039	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
634458007040	intersubunit interface [polypeptide binding]; other site
634458007041	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
634458007042	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
634458007043	Cl- selectivity filter; other site
634458007044	Cl- binding residues [ion binding]; other site
634458007045	pore gating glutamate residue; other site
634458007046	dimer interface [polypeptide binding]; other site
634458007047	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
634458007048	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
634458007049	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
634458007050	NAD(P) binding site [chemical binding]; other site
634458007051	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
634458007052	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634458007053	catalytic residue [active]
634458007054	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
634458007055	potassium uptake protein; Region: kup; TIGR00794
634458007056	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
634458007057	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458007058	FeS/SAM binding site; other site
634458007059	HemN C-terminal domain; Region: HemN_C; pfam06969
634458007060	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
634458007061	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
634458007062	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
634458007063	Walker A/P-loop; other site
634458007064	ATP binding site [chemical binding]; other site
634458007065	Q-loop/lid; other site
634458007066	ABC transporter signature motif; other site
634458007067	Walker B; other site
634458007068	D-loop; other site
634458007069	H-loop/switch region; other site
634458007070	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
634458007071	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
634458007072	Walker A/P-loop; other site
634458007073	ATP binding site [chemical binding]; other site
634458007074	Q-loop/lid; other site
634458007075	ABC transporter signature motif; other site
634458007076	Walker B; other site
634458007077	D-loop; other site
634458007078	H-loop/switch region; other site
634458007079	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
634458007080	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
634458007081	TM-ABC transporter signature motif; other site
634458007082	HEAT repeats; Region: HEAT_2; pfam13646
634458007083	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
634458007084	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
634458007085	TM-ABC transporter signature motif; other site
634458007086	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
634458007087	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
634458007088	putative ligand binding site [chemical binding]; other site
634458007089	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
634458007090	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
634458007091	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
634458007092	dimer interface [polypeptide binding]; other site
634458007093	phosphorylation site [posttranslational modification]
634458007094	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
634458007095	ATP binding site [chemical binding]; other site
634458007096	Mg2+ binding site [ion binding]; other site
634458007097	G-X-G motif; other site
634458007098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458007099	Response regulator receiver domain; Region: Response_reg; pfam00072
634458007100	active site
634458007101	phosphorylation site [posttranslational modification]
634458007102	intermolecular recognition site; other site
634458007103	dimerization interface [polypeptide binding]; other site
634458007104	Response regulator receiver domain; Region: Response_reg; pfam00072
634458007105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458007106	active site
634458007107	phosphorylation site [posttranslational modification]
634458007108	intermolecular recognition site; other site
634458007109	dimerization interface [polypeptide binding]; other site
634458007110	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
634458007111	DNA binding residues [nucleotide binding]
634458007112	HTH-like domain; Region: HTH_21; pfam13276
634458007113	Integrase core domain; Region: rve; pfam00665
634458007114	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458007115	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634458007116	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
634458007117	UreF; Region: UreF; pfam01730
634458007118	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
634458007119	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
634458007120	dimer interface [polypeptide binding]; other site
634458007121	catalytic residues [active]
634458007122	urease subunit alpha; Reviewed; Region: ureC; PRK13207
634458007123	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
634458007124	subunit interactions [polypeptide binding]; other site
634458007125	active site
634458007126	flap region; other site
634458007127	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
634458007128	alpha-beta subunit interface [polypeptide binding]; other site
634458007129	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
634458007130	alpha-gamma subunit interface [polypeptide binding]; other site
634458007131	beta-gamma subunit interface [polypeptide binding]; other site
634458007132	UreD urease accessory protein; Region: UreD; pfam01774
634458007133	High-affinity nickel-transport protein; Region: NicO; cl00964
634458007134	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
634458007135	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
634458007136	dimer interface [polypeptide binding]; other site
634458007137	PYR/PP interface [polypeptide binding]; other site
634458007138	TPP binding site [chemical binding]; other site
634458007139	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
634458007140	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
634458007141	TPP-binding site [chemical binding]; other site
634458007142	dimer interface [polypeptide binding]; other site
634458007143	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
634458007144	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
634458007145	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
634458007146	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
634458007147	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
634458007148	heme binding site [chemical binding]; other site
634458007149	ferroxidase pore; other site
634458007150	ferroxidase diiron center [ion binding]; other site
634458007151	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
634458007152	ArsC family; Region: ArsC; pfam03960
634458007153	putative catalytic residues [active]
634458007154	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
634458007155	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
634458007156	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634458007157	dimerization interface [polypeptide binding]; other site
634458007158	putative DNA binding site [nucleotide binding]; other site
634458007159	putative Zn2+ binding site [ion binding]; other site
634458007160	peroxiredoxin; Provisional; Region: PRK13189
634458007161	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
634458007162	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
634458007163	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
634458007164	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
634458007165	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
634458007166	Sulfate transporter family; Region: Sulfate_transp; pfam00916
634458007167	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
634458007168	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
634458007169	catalytic residues [active]
634458007170	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458007171	Pirin-related protein [General function prediction only]; Region: COG1741
634458007172	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634458007173	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
634458007174	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458007175	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458007176	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
634458007177	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458007178	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458007179	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458007180	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
634458007181	putative dimerization interface [polypeptide binding]; other site
634458007182	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458007183	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634458007184	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
634458007185	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458007186	putative substrate translocation pore; other site
634458007187	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458007188	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458007189	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
634458007190	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634458007191	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
634458007192	Isochorismatase family; Region: Isochorismatase; pfam00857
634458007193	catalytic triad [active]
634458007194	conserved cis-peptide bond; other site
634458007195	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
634458007196	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634458007197	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
634458007198	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634458007199	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
634458007200	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
634458007201	Cytochrome c; Region: Cytochrom_C; pfam00034
634458007202	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634458007203	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
634458007204	Cytochrome c; Region: Cytochrom_C; pfam00034
634458007205	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
634458007206	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
634458007207	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
634458007208	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634458007209	Transcriptional regulators [Transcription]; Region: MarR; COG1846
634458007210	MarR family; Region: MarR_2; pfam12802
634458007211	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458007212	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
634458007213	active site
634458007214	catalytic triad [active]
634458007215	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458007216	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
634458007217	Walker A motif; other site
634458007218	ATP binding site [chemical binding]; other site
634458007219	Walker B motif; other site
634458007220	arginine finger; other site
634458007221	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
634458007222	putative transposase OrfB; Reviewed; Region: PHA02517
634458007223	HTH-like domain; Region: HTH_21; pfam13276
634458007224	Integrase core domain; Region: rve; pfam00665
634458007225	Integrase core domain; Region: rve_3; pfam13683
634458007226	Transposase; Region: HTH_Tnp_1; cl17663
634458007227	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
634458007228	conjugal transfer protein TrbF; Provisional; Region: PRK13872
634458007229	conjugal transfer protein TrbL; Provisional; Region: PRK13875
634458007230	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
634458007231	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458007232	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634458007233	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
634458007234	catalytic residues [active]
634458007235	catalytic nucleophile [active]
634458007236	Recombinase; Region: Recombinase; pfam07508
634458007237	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
634458007238	non-specific DNA binding site [nucleotide binding]; other site
634458007239	salt bridge; other site
634458007240	sequence-specific DNA binding site [nucleotide binding]; other site
634458007241	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
634458007242	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458007243	putative transposase OrfB; Reviewed; Region: PHA02517
634458007244	HTH-like domain; Region: HTH_21; pfam13276
634458007245	Integrase core domain; Region: rve; pfam00665
634458007246	Integrase core domain; Region: rve_3; pfam13683
634458007247	Transposase; Region: HTH_Tnp_1; cl17663
634458007248	Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074
634458007249	Replication initiator protein A; Region: RPA; pfam10134
634458007250	putative transposase OrfB; Reviewed; Region: PHA02517
634458007251	HTH-like domain; Region: HTH_21; pfam13276
634458007252	Integrase core domain; Region: rve; pfam00665
634458007253	Integrase core domain; Region: rve_3; pfam13683
634458007254	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458007255	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458007256	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
634458007257	NAD(P) binding site [chemical binding]; other site
634458007258	active site
634458007259	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
634458007260	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
634458007261	Protein required for attachment to host cells; Region: Host_attach; pfam10116
634458007262	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
634458007263	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
634458007264	XdhC Rossmann domain; Region: XdhC_C; pfam13478
634458007265	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
634458007266	Ligand binding site; other site
634458007267	metal-binding site
634458007268	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
634458007269	homotrimer interaction site [polypeptide binding]; other site
634458007270	putative active site [active]
634458007271	CHAP domain; Region: CHAP; cl17642
634458007272	glycine dehydrogenase; Provisional; Region: PRK05367
634458007273	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
634458007274	tetramer interface [polypeptide binding]; other site
634458007275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458007276	catalytic residue [active]
634458007277	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
634458007278	tetramer interface [polypeptide binding]; other site
634458007279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458007280	catalytic residue [active]
634458007281	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
634458007282	lipoyl attachment site [posttranslational modification]; other site
634458007283	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
634458007284	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
634458007285	spermidine synthase; Provisional; Region: PRK00811
634458007286	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458007287	S-adenosylmethionine binding site [chemical binding]; other site
634458007288	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
634458007289	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458007290	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458007291	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634458007292	putative effector binding pocket; other site
634458007293	dimerization interface [polypeptide binding]; other site
634458007294	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
634458007295	active site
634458007296	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
634458007297	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
634458007298	active site
634458007299	(T/H)XGH motif; other site
634458007300	DNA gyrase, A subunit; Region: gyrA; TIGR01063
634458007301	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
634458007302	CAP-like domain; other site
634458007303	active site
634458007304	primary dimer interface [polypeptide binding]; other site
634458007305	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634458007306	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634458007307	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634458007308	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
634458007309	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
634458007310	FMN binding site [chemical binding]; other site
634458007311	substrate binding site [chemical binding]; other site
634458007312	putative catalytic residue [active]
634458007313	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
634458007314	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
634458007315	RNase E interface [polypeptide binding]; other site
634458007316	trimer interface [polypeptide binding]; other site
634458007317	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
634458007318	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
634458007319	RNase E interface [polypeptide binding]; other site
634458007320	trimer interface [polypeptide binding]; other site
634458007321	active site
634458007322	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
634458007323	putative nucleic acid binding region [nucleotide binding]; other site
634458007324	G-X-X-G motif; other site
634458007325	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
634458007326	RNA binding site [nucleotide binding]; other site
634458007327	domain interface; other site
634458007328	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
634458007329	16S/18S rRNA binding site [nucleotide binding]; other site
634458007330	S13e-L30e interaction site [polypeptide binding]; other site
634458007331	25S rRNA binding site [nucleotide binding]; other site
634458007332	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
634458007333	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
634458007334	RNA binding site [nucleotide binding]; other site
634458007335	active site
634458007336	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
634458007337	Permease; Region: Permease; pfam02405
634458007338	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
634458007339	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
634458007340	Walker A/P-loop; other site
634458007341	ATP binding site [chemical binding]; other site
634458007342	Q-loop/lid; other site
634458007343	ABC transporter signature motif; other site
634458007344	Walker B; other site
634458007345	D-loop; other site
634458007346	H-loop/switch region; other site
634458007347	mce related protein; Region: MCE; pfam02470
634458007348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
634458007349	Protein of unknown function (DUF330); Region: DUF330; pfam03886
634458007350	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458007351	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
634458007352	putative ADP-binding pocket [chemical binding]; other site
634458007353	Clostridial hydrophobic W; Region: ChW; cl02763
634458007354	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
634458007355	binding surface
634458007356	TPR motif; other site
634458007357	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
634458007358	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634458007359	active site
634458007360	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634458007361	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458007362	FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659
634458007363	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634458007364	Sel1-like repeats; Region: SEL1; smart00671
634458007365	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
634458007366	Sel1-like repeats; Region: SEL1; smart00671
634458007367	Sel1-like repeats; Region: SEL1; smart00671
634458007368	Sel1 repeat; Region: Sel1; cl02723
634458007369	Sel1-like repeats; Region: SEL1; smart00671
634458007370	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
634458007371	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
634458007372	HlyD family secretion protein; Region: HlyD_3; pfam13437
634458007373	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
634458007374	putative active site [active]
634458007375	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
634458007376	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634458007377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458007378	Walker A/P-loop; other site
634458007379	ATP binding site [chemical binding]; other site
634458007380	Q-loop/lid; other site
634458007381	ABC transporter signature motif; other site
634458007382	Walker B; other site
634458007383	D-loop; other site
634458007384	H-loop/switch region; other site
634458007385	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
634458007386	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
634458007387	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
634458007388	substrate binding pocket [chemical binding]; other site
634458007389	dimer interface [polypeptide binding]; other site
634458007390	inhibitor binding site; inhibition site
634458007391	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
634458007392	B12 binding site [chemical binding]; other site
634458007393	cobalt ligand [ion binding]; other site
634458007394	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
634458007395	Colicin V production protein; Region: Colicin_V; pfam02674
634458007396	amidophosphoribosyltransferase; Provisional; Region: PRK09123
634458007397	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
634458007398	active site
634458007399	tetramer interface [polypeptide binding]; other site
634458007400	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
634458007401	active site
634458007402	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
634458007403	Protein of unknown function (DUF330); Region: DUF330; pfam03886
634458007404	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
634458007405	mce related protein; Region: MCE; pfam02470
634458007406	mce related protein; Region: MCE; pfam02470
634458007407	mce related protein; Region: MCE; pfam02470
634458007408	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
634458007409	Paraquat-inducible protein A; Region: PqiA; pfam04403
634458007410	Paraquat-inducible protein A; Region: PqiA; pfam04403
634458007411	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
634458007412	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
634458007413	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
634458007414	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
634458007415	active site
634458007416	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
634458007417	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
634458007418	ATP synthase subunit C; Region: ATP-synt_C; cl00466
634458007419	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
634458007420	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
634458007421	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
634458007422	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
634458007423	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
634458007424	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
634458007425	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
634458007426	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
634458007427	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458007428	FeS/SAM binding site; other site
634458007429	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
634458007430	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
634458007431	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
634458007432	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634458007433	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
634458007434	dimer interface [polypeptide binding]; other site
634458007435	active site
634458007436	metal binding site [ion binding]; metal-binding site
634458007437	glutathione binding site [chemical binding]; other site
634458007438	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634458007439	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
634458007440	ATP binding site [chemical binding]; other site
634458007441	Mg++ binding site [ion binding]; other site
634458007442	motif III; other site
634458007443	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
634458007444	nucleotide binding region [chemical binding]; other site
634458007445	ATP-binding site [chemical binding]; other site
634458007446	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
634458007447	RNA binding site [nucleotide binding]; other site
634458007448	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
634458007449	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
634458007450	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
634458007451	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
634458007452	23S rRNA interface [nucleotide binding]; other site
634458007453	L3 interface [polypeptide binding]; other site
634458007454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458007455	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
634458007456	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
634458007457	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
634458007458	PhoU domain; Region: PhoU; pfam01895
634458007459	PhoU domain; Region: PhoU; pfam01895
634458007460	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
634458007461	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
634458007462	Walker A/P-loop; other site
634458007463	ATP binding site [chemical binding]; other site
634458007464	Q-loop/lid; other site
634458007465	ABC transporter signature motif; other site
634458007466	Walker B; other site
634458007467	D-loop; other site
634458007468	H-loop/switch region; other site
634458007469	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
634458007470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458007471	dimer interface [polypeptide binding]; other site
634458007472	conserved gate region; other site
634458007473	putative PBP binding loops; other site
634458007474	ABC-ATPase subunit interface; other site
634458007475	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
634458007476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458007477	dimer interface [polypeptide binding]; other site
634458007478	conserved gate region; other site
634458007479	putative PBP binding loops; other site
634458007480	ABC-ATPase subunit interface; other site
634458007481	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
634458007482	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
634458007483	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
634458007484	NADP binding site [chemical binding]; other site
634458007485	dimer interface [polypeptide binding]; other site
634458007486	Predicted membrane protein [Function unknown]; Region: COG1289
634458007487	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
634458007488	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
634458007489	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634458007490	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634458007491	protein binding site [polypeptide binding]; other site
634458007492	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634458007493	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
634458007494	active site
634458007495	catalytic triad [active]
634458007496	oxyanion hole [active]
634458007497	OpgC protein; Region: OpgC_C; pfam10129
634458007498	Acyltransferase family; Region: Acyl_transf_3; pfam01757
634458007499	antiporter inner membrane protein; Provisional; Region: PRK11670
634458007500	Domain of unknown function DUF59; Region: DUF59; pfam01883
634458007501	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
634458007502	Walker A motif; other site
634458007503	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
634458007504	Stringent starvation protein B; Region: SspB; cl01120
634458007505	fumarate hydratase; Provisional; Region: PRK15389
634458007506	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
634458007507	Fumarase C-terminus; Region: Fumerase_C; pfam05683
634458007508	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
634458007509	dimer interface [polypeptide binding]; other site
634458007510	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
634458007511	metal binding site [ion binding]; metal-binding site
634458007512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
634458007513	AntA/AntB antirepressor; Region: AntA; cl01430
634458007514	Putative glucoamylase; Region: Glycoamylase; pfam10091
634458007515	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
634458007516	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
634458007517	hydroxyglutarate oxidase; Provisional; Region: PRK11728
634458007518	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
634458007519	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
634458007520	active site
634458007521	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634458007522	dimer interface [polypeptide binding]; other site
634458007523	substrate binding site [chemical binding]; other site
634458007524	catalytic residues [active]
634458007525	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
634458007526	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
634458007527	putative DNA binding site [nucleotide binding]; other site
634458007528	putative Zn2+ binding site [ion binding]; other site
634458007529	AsnC family; Region: AsnC_trans_reg; pfam01037
634458007530	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
634458007531	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
634458007532	translation initiation factor IF-2; Region: IF-2; TIGR00487
634458007533	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
634458007534	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
634458007535	G1 box; other site
634458007536	putative GEF interaction site [polypeptide binding]; other site
634458007537	GTP/Mg2+ binding site [chemical binding]; other site
634458007538	Switch I region; other site
634458007539	G2 box; other site
634458007540	G3 box; other site
634458007541	Switch II region; other site
634458007542	G4 box; other site
634458007543	G5 box; other site
634458007544	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
634458007545	Translation-initiation factor 2; Region: IF-2; pfam11987
634458007546	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
634458007547	hypothetical protein; Provisional; Region: PRK09190
634458007548	Protein of unknown function (DUF448); Region: DUF448; pfam04296
634458007549	putative RNA binding cleft [nucleotide binding]; other site
634458007550	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
634458007551	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
634458007552	NusA N-terminal domain; Region: NusA_N; pfam08529
634458007553	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
634458007554	RNA binding site [nucleotide binding]; other site
634458007555	homodimer interface [polypeptide binding]; other site
634458007556	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
634458007557	G-X-X-G motif; other site
634458007558	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
634458007559	G-X-X-G motif; other site
634458007560	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
634458007561	hypothetical protein; Provisional; Region: PRK14636
634458007562	Sm and related proteins; Region: Sm_like; cl00259
634458007563	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
634458007564	putative RNA binding site [nucleotide binding]; other site
634458007565	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
634458007566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458007567	Walker A motif; other site
634458007568	ATP binding site [chemical binding]; other site
634458007569	Walker B motif; other site
634458007570	arginine finger; other site
634458007571	Transcriptional regulator [Transcription]; Region: LysR; COG0583
634458007572	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458007573	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
634458007574	putative effector binding pocket; other site
634458007575	dimerization interface [polypeptide binding]; other site
634458007576	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
634458007577	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
634458007578	substrate binding pocket [chemical binding]; other site
634458007579	membrane-bound complex binding site; other site
634458007580	hinge residues; other site
634458007581	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
634458007582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
634458007583	dimer interface [polypeptide binding]; other site
634458007584	conserved gate region; other site
634458007585	putative PBP binding loops; other site
634458007586	ABC-ATPase subunit interface; other site
634458007587	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
634458007588	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458007589	Walker A/P-loop; other site
634458007590	ATP binding site [chemical binding]; other site
634458007591	Q-loop/lid; other site
634458007592	ABC transporter signature motif; other site
634458007593	Walker B; other site
634458007594	D-loop; other site
634458007595	H-loop/switch region; other site
634458007596	aconitate hydratase; Validated; Region: PRK09277
634458007597	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
634458007598	substrate binding site [chemical binding]; other site
634458007599	ligand binding site [chemical binding]; other site
634458007600	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
634458007601	substrate binding site [chemical binding]; other site
634458007602	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
634458007603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458007604	Walker A/P-loop; other site
634458007605	ATP binding site [chemical binding]; other site
634458007606	Q-loop/lid; other site
634458007607	ABC transporter signature motif; other site
634458007608	Walker B; other site
634458007609	D-loop; other site
634458007610	H-loop/switch region; other site
634458007611	CcmB protein; Region: CcmB; pfam03379
634458007612	hypothetical protein; Provisional; Region: PRK10316
634458007613	YfdX protein; Region: YfdX; pfam10938
634458007614	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
634458007615	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
634458007616	dimer interface [polypeptide binding]; other site
634458007617	active site
634458007618	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
634458007619	catalytic residues [active]
634458007620	substrate binding site [chemical binding]; other site
634458007621	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
634458007622	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
634458007623	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
634458007624	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
634458007625	Dehydroquinase class II; Region: DHquinase_II; pfam01220
634458007626	trimer interface [polypeptide binding]; other site
634458007627	active site
634458007628	dimer interface [polypeptide binding]; other site
634458007629	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
634458007630	carboxyltransferase (CT) interaction site; other site
634458007631	biotinylation site [posttranslational modification]; other site
634458007632	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
634458007633	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
634458007634	ATP-grasp domain; Region: ATP-grasp_4; cl17255
634458007635	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
634458007636	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
634458007637	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458007638	putative substrate translocation pore; other site
634458007639	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458007640	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
634458007641	ThiC-associated domain; Region: ThiC-associated; pfam13667
634458007642	ThiC family; Region: ThiC; pfam01964
634458007643	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
634458007644	Iron permease FTR1 family; Region: FTR1; cl00475
634458007645	Fe2+ transport protein; Region: Iron_transport; cl01377
634458007646	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634458007647	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
634458007648	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
634458007649	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
634458007650	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
634458007651	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
634458007652	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
634458007653	dimerization interface [polypeptide binding]; other site
634458007654	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
634458007655	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
634458007656	inhibitor-cofactor binding pocket; inhibition site
634458007657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
634458007658	catalytic residue [active]
634458007659	Synuclein; Region: Synuclein; pfam01387
634458007660	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
634458007661	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
634458007662	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
634458007663	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
634458007664	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
634458007665	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
634458007666	GatB domain; Region: GatB_Yqey; smart00845
634458007667	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
634458007668	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
634458007669	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
634458007670	Walker A/P-loop; other site
634458007671	ATP binding site [chemical binding]; other site
634458007672	Q-loop/lid; other site
634458007673	ABC transporter signature motif; other site
634458007674	Walker B; other site
634458007675	D-loop; other site
634458007676	H-loop/switch region; other site
634458007677	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
634458007678	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
634458007679	minor groove reading motif; other site
634458007680	helix-hairpin-helix signature motif; other site
634458007681	substrate binding pocket [chemical binding]; other site
634458007682	active site
634458007683	ferrochelatase; Reviewed; Region: hemH; PRK00035
634458007684	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
634458007685	C-terminal domain interface [polypeptide binding]; other site
634458007686	active site
634458007687	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
634458007688	active site
634458007689	N-terminal domain interface [polypeptide binding]; other site
634458007690	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
634458007691	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
634458007692	minor groove reading motif; other site
634458007693	helix-hairpin-helix signature motif; other site
634458007694	substrate binding pocket [chemical binding]; other site
634458007695	active site
634458007696	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
634458007697	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
634458007698	DNA binding and oxoG recognition site [nucleotide binding]
634458007699	Protein of unknown function (DUF721); Region: DUF721; cl02324
634458007700	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
634458007701	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
634458007702	N-acetyl-D-glucosamine binding site [chemical binding]; other site
634458007703	catalytic residue [active]
634458007704	Sporulation related domain; Region: SPOR; cl10051
634458007705	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
634458007706	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
634458007707	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
634458007708	HIGH motif; other site
634458007709	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
634458007710	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
634458007711	active site
634458007712	KMSKS motif; other site
634458007713	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
634458007714	tRNA binding surface [nucleotide binding]; other site
634458007715	Lipopolysaccharide-assembly; Region: LptE; pfam04390
634458007716	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
634458007717	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
634458007718	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
634458007719	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
634458007720	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
634458007721	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
634458007722	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
634458007723	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
634458007724	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
634458007725	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
634458007726	Ligand binding site [chemical binding]; other site
634458007727	Electron transfer flavoprotein domain; Region: ETF; pfam01012
634458007728	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
634458007729	hydroxyglutarate oxidase; Provisional; Region: PRK11728
634458007730	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
634458007731	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
634458007732	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
634458007733	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
634458007734	FeS/SAM binding site; other site
634458007735	HemN C-terminal domain; Region: HemN_C; pfam06969
634458007736	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
634458007737	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
634458007738	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
634458007739	ligand binding site [chemical binding]; other site
634458007740	flexible hinge region; other site
634458007741	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
634458007742	putative switch regulator; other site
634458007743	non-specific DNA interactions [nucleotide binding]; other site
634458007744	DNA binding site [nucleotide binding]
634458007745	sequence specific DNA binding site [nucleotide binding]; other site
634458007746	putative cAMP binding site [chemical binding]; other site
634458007747	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
634458007748	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
634458007749	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634458007750	protein binding site [polypeptide binding]; other site
634458007751	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
634458007752	protein binding site [polypeptide binding]; other site
634458007753	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
634458007754	nucleoside/Zn binding site; other site
634458007755	dimer interface [polypeptide binding]; other site
634458007756	catalytic motif [active]
634458007757	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
634458007758	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
634458007759	catalytic triad [active]
634458007760	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
634458007761	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
634458007762	RNA binding surface [nucleotide binding]; other site
634458007763	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
634458007764	active site
634458007765	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
634458007766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
634458007767	S-adenosylmethionine binding site [chemical binding]; other site
634458007768	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
634458007769	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
634458007770	dimer interface [polypeptide binding]; other site
634458007771	ssDNA binding site [nucleotide binding]; other site
634458007772	tetramer (dimer of dimers) interface [polypeptide binding]; other site
634458007773	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
634458007774	O-Antigen ligase; Region: Wzy_C; pfam04932
634458007775	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
634458007776	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
634458007777	active site
634458007778	catalytic residues [active]
634458007779	DNA binding site [nucleotide binding]
634458007780	Int/Topo IB signature motif; other site
634458007781	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634458007782	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458007783	catalytic residues [active]
634458007784	catalytic nucleophile [active]
634458007785	Presynaptic Site I dimer interface [polypeptide binding]; other site
634458007786	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634458007787	Synaptic Flat tetramer interface [polypeptide binding]; other site
634458007788	Synaptic Site I dimer interface [polypeptide binding]; other site
634458007789	DNA binding site [nucleotide binding]
634458007790	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458007791	DNA-binding interface [nucleotide binding]; DNA binding site
634458007792	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458007793	DEAD-like helicases superfamily; Region: DEXDc; smart00487
634458007794	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
634458007795	ATP binding site [chemical binding]; other site
634458007796	putative Mg++ binding site [ion binding]; other site
634458007797	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458007798	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458007799	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458007800	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458007801	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
634458007802	putative ADP-binding pocket [chemical binding]; other site
634458007803	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
634458007804	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
634458007805	active site
634458007806	HIGH motif; other site
634458007807	dimer interface [polypeptide binding]; other site
634458007808	KMSKS motif; other site
634458007809	protease TldD; Provisional; Region: tldD; PRK10735
634458007810	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
634458007811	catalytic core [active]
634458007812	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
634458007813	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
634458007814	NAD binding site [chemical binding]; other site
634458007815	substrate binding site [chemical binding]; other site
634458007816	homodimer interface [polypeptide binding]; other site
634458007817	active site
634458007818	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
634458007819	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
634458007820	substrate binding site; other site
634458007821	tetramer interface; other site
634458007822	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
634458007823	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
634458007824	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
634458007825	NADP binding site [chemical binding]; other site
634458007826	active site
634458007827	putative substrate binding site [chemical binding]; other site
634458007828	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634458007829	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
634458007830	Probable Catalytic site; other site
634458007831	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
634458007832	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
634458007833	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
634458007834	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
634458007835	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
634458007836	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
634458007837	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458007838	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
634458007839	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
634458007840	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634458007841	putative C-terminal domain interface [polypeptide binding]; other site
634458007842	putative GSH binding site (G-site) [chemical binding]; other site
634458007843	putative dimer interface [polypeptide binding]; other site
634458007844	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
634458007845	putative N-terminal domain interface [polypeptide binding]; other site
634458007846	putative dimer interface [polypeptide binding]; other site
634458007847	putative substrate binding pocket (H-site) [chemical binding]; other site
634458007848	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
634458007849	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
634458007850	Ligand Binding Site [chemical binding]; other site
634458007851	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
634458007852	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
634458007853	catalytic loop [active]
634458007854	iron binding site [ion binding]; other site
634458007855	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
634458007856	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
634458007857	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634458007858	catalytic residue [active]
634458007859	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
634458007860	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
634458007861	catalytic residue [active]
634458007862	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
634458007863	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
634458007864	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
634458007865	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
634458007866	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
634458007867	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
634458007868	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
634458007869	active site
634458007870	HIGH motif; other site
634458007871	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
634458007872	KMSKS motif; other site
634458007873	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
634458007874	tRNA binding surface [nucleotide binding]; other site
634458007875	anticodon binding site; other site
634458007876	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
634458007877	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
634458007878	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
634458007879	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
634458007880	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
634458007881	catalytic residues [active]
634458007882	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
634458007883	Family description; Region: UvrD_C_2; pfam13538
634458007884	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
634458007885	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
634458007886	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
634458007887	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
634458007888	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
634458007889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
634458007890	active site
634458007891	phosphorylation site [posttranslational modification]
634458007892	intermolecular recognition site; other site
634458007893	dimerization interface [polypeptide binding]; other site
634458007894	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
634458007895	DNA binding site [nucleotide binding]
634458007896	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
634458007897	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
634458007898	active site
634458007899	substrate binding site [chemical binding]; other site
634458007900	metal binding site [ion binding]; metal-binding site
634458007901	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
634458007902	dihydropteroate synthase; Region: DHPS; TIGR01496
634458007903	substrate binding pocket [chemical binding]; other site
634458007904	dimer interface [polypeptide binding]; other site
634458007905	inhibitor binding site; inhibition site
634458007906	FtsH Extracellular; Region: FtsH_ext; pfam06480
634458007907	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
634458007908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458007909	Walker A motif; other site
634458007910	ATP binding site [chemical binding]; other site
634458007911	Walker B motif; other site
634458007912	arginine finger; other site
634458007913	Peptidase family M41; Region: Peptidase_M41; pfam01434
634458007914	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
634458007915	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
634458007916	Ligand Binding Site [chemical binding]; other site
634458007917	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
634458007918	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
634458007919	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
634458007920	ligand binding site [chemical binding]; other site
634458007921	translocation protein TolB; Provisional; Region: tolB; PRK05137
634458007922	TolB amino-terminal domain; Region: TolB_N; pfam04052
634458007923	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
634458007924	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
634458007925	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
634458007926	TolR protein; Region: tolR; TIGR02801
634458007927	TolQ protein; Region: tolQ; TIGR02796
634458007928	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
634458007929	active site
634458007930	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
634458007931	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
634458007932	Walker A motif; other site
634458007933	ATP binding site [chemical binding]; other site
634458007934	Walker B motif; other site
634458007935	arginine finger; other site
634458007936	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
634458007937	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
634458007938	RuvA N terminal domain; Region: RuvA_N; pfam01330
634458007939	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
634458007940	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
634458007941	active site
634458007942	putative DNA-binding cleft [nucleotide binding]; other site
634458007943	dimer interface [polypeptide binding]; other site
634458007944	hypothetical protein; Validated; Region: PRK00110
634458007945	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
634458007946	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
634458007947	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
634458007948	nucleotide binding region [chemical binding]; other site
634458007949	ATP-binding site [chemical binding]; other site
634458007950	SEC-C motif; Region: SEC-C; pfam02810
634458007951	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
634458007952	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
634458007953	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
634458007954	heterotetramer interface [polypeptide binding]; other site
634458007955	active site pocket [active]
634458007956	cleavage site
634458007957	RDD family; Region: RDD; pfam06271
634458007958	putative mechanosensitive channel protein; Provisional; Region: PRK11465
634458007959	Mechanosensitive ion channel; Region: MS_channel; pfam00924
634458007960	Biofilm formation and stress response factor; Region: BsmA; pfam10014
634458007961	chaperone protein DnaJ; Provisional; Region: PRK14299
634458007962	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
634458007963	HSP70 interaction site [polypeptide binding]; other site
634458007964	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
634458007965	substrate binding site [polypeptide binding]; other site
634458007966	dimer interface [polypeptide binding]; other site
634458007967	Membrane fusogenic activity; Region: BMFP; pfam04380
634458007968	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
634458007969	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
634458007970	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
634458007971	H+ Antiporter protein; Region: 2A0121; TIGR00900
634458007972	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
634458007973	IHF dimer interface [polypeptide binding]; other site
634458007974	IHF - DNA interface [nucleotide binding]; other site
634458007975	Rhamnan synthesis protein F; Region: RgpF; pfam05045
634458007976	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
634458007977	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458007978	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458007979	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
634458007980	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
634458007981	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
634458007982	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
634458007983	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
634458007984	active site
634458007985	NAD synthetase; Reviewed; Region: nadE; PRK02628
634458007986	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
634458007987	multimer interface [polypeptide binding]; other site
634458007988	active site
634458007989	catalytic triad [active]
634458007990	protein interface 1 [polypeptide binding]; other site
634458007991	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
634458007992	homodimer interface [polypeptide binding]; other site
634458007993	NAD binding pocket [chemical binding]; other site
634458007994	ATP binding pocket [chemical binding]; other site
634458007995	Mg binding site [ion binding]; other site
634458007996	active-site loop [active]
634458007997	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
634458007998	putative active site pocket [active]
634458007999	4-fold oligomerization interface [polypeptide binding]; other site
634458008000	metal binding residues [ion binding]; metal-binding site
634458008001	3-fold/trimer interface [polypeptide binding]; other site
634458008002	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
634458008003	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
634458008004	putative active site [active]
634458008005	oxyanion strand; other site
634458008006	catalytic triad [active]
634458008007	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
634458008008	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
634458008009	Coenzyme A binding pocket [chemical binding]; other site
634458008010	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
634458008011	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
634458008012	catalytic residues [active]
634458008013	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
634458008014	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
634458008015	substrate binding site [chemical binding]; other site
634458008016	glutamase interaction surface [polypeptide binding]; other site
634458008017	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
634458008018	metal binding site [ion binding]; metal-binding site
634458008019	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
634458008020	nucleotide binding site/active site [active]
634458008021	HIT family signature motif; other site
634458008022	catalytic residue [active]
634458008023	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
634458008024	putative FMN binding site [chemical binding]; other site
634458008025	hypothetical protein; Provisional; Region: PRK09126
634458008026	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
634458008027	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
634458008028	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
634458008029	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
634458008030	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
634458008031	putative C-terminal domain interface [polypeptide binding]; other site
634458008032	putative GSH binding site (G-site) [chemical binding]; other site
634458008033	putative dimer interface [polypeptide binding]; other site
634458008034	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
634458008035	putative N-terminal domain interface [polypeptide binding]; other site
634458008036	putative dimer interface [polypeptide binding]; other site
634458008037	putative substrate binding pocket (H-site) [chemical binding]; other site
634458008038	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
634458008039	ParB-like nuclease domain; Region: ParB; smart00470
634458008040	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634458008041	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634458008042	P-loop; other site
634458008043	Magnesium ion binding site [ion binding]; other site
634458008044	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634458008045	Magnesium ion binding site [ion binding]; other site
634458008046	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
634458008047	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
634458008048	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
634458008049	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
634458008050	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
634458008051	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
634458008052	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
634458008053	trmE is a tRNA modification GTPase; Region: trmE; cd04164
634458008054	G1 box; other site
634458008055	GTP/Mg2+ binding site [chemical binding]; other site
634458008056	Switch I region; other site
634458008057	G2 box; other site
634458008058	Switch II region; other site
634458008059	G3 box; other site
634458008060	G4 box; other site
634458008061	G5 box; other site
634458008062	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
634458008063	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
634458008064	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
634458008065	DNA binding site [nucleotide binding]
634458008066	active site
634458008067	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
634458008068	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458008069	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
634458008070	major facilitator superfamily transporter; Provisional; Region: PRK05122
634458008071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
634458008072	putative substrate translocation pore; other site
634458008073	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
634458008074	dimer interface [polypeptide binding]; other site
634458008075	ADP-ribose binding site [chemical binding]; other site
634458008076	active site
634458008077	nudix motif; other site
634458008078	metal binding site [ion binding]; metal-binding site
634458008079	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
634458008080	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
634458008081	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
634458008082	motif II; other site
634458008083	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
634458008084	substrate binding site [chemical binding]; other site
634458008085	active site
634458008086	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
634458008087	active site
634458008088	dimer interface [polypeptide binding]; other site
634458008089	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
634458008090	Phage Terminase; Region: Terminase_1; pfam03354
634458008091	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634458008092	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458008093	catalytic residues [active]
634458008094	catalytic nucleophile [active]
634458008095	Presynaptic Site I dimer interface [polypeptide binding]; other site
634458008096	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634458008097	Synaptic Flat tetramer interface [polypeptide binding]; other site
634458008098	Synaptic Site I dimer interface [polypeptide binding]; other site
634458008099	DNA binding site [nucleotide binding]
634458008100	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458008101	DNA-binding interface [nucleotide binding]; DNA binding site
634458008102	hypothetical protein; Provisional; Region: PRK14709
634458008103	D5 N terminal like; Region: D5_N; smart00885
634458008104	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
634458008105	polymerase nucleotide-binding site; other site
634458008106	DNA-binding residues [nucleotide binding]; DNA binding site
634458008107	nucleotide binding site [chemical binding]; other site
634458008108	primase nucleotide-binding site [nucleotide binding]; other site
634458008109	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
634458008110	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634458008111	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458008112	catalytic residues [active]
634458008113	catalytic nucleophile [active]
634458008114	Presynaptic Site I dimer interface [polypeptide binding]; other site
634458008115	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634458008116	Synaptic Flat tetramer interface [polypeptide binding]; other site
634458008117	Synaptic Site I dimer interface [polypeptide binding]; other site
634458008118	DNA binding site [nucleotide binding]
634458008119	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458008120	DNA-binding interface [nucleotide binding]; DNA binding site
634458008121	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569
634458008122	Conjugal transfer protein TraD; Region: TraD; pfam06412
634458008123	putative transposase OrfB; Reviewed; Region: PHA02517
634458008124	HTH-like domain; Region: HTH_21; pfam13276
634458008125	Integrase core domain; Region: rve; pfam00665
634458008126	Integrase core domain; Region: rve_3; pfam13683
634458008127	Transposase; Region: HTH_Tnp_1; cl17663
634458008128	Hint domain; Region: Hint_2; pfam13403
634458008129	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
634458008130	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
634458008131	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634458008132	HTH-like domain; Region: HTH_21; pfam13276
634458008133	Integrase core domain; Region: rve; pfam00665
634458008134	Integrase core domain; Region: rve_3; pfam13683
634458008135	Transposase; Region: HTH_Tnp_1; pfam01527
634458008136	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
634458008137	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634458008138	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458008139	DNA-binding interface [nucleotide binding]; DNA binding site
634458008140	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634458008141	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458008142	catalytic residues [active]
634458008143	catalytic nucleophile [active]
634458008144	Presynaptic Site I dimer interface [polypeptide binding]; other site
634458008145	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634458008146	Synaptic Flat tetramer interface [polypeptide binding]; other site
634458008147	Synaptic Site I dimer interface [polypeptide binding]; other site
634458008148	DNA binding site [nucleotide binding]
634458008149	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458008150	DNA-binding interface [nucleotide binding]; DNA binding site
634458008151	Winged helix-turn helix; Region: HTH_29; pfam13551
634458008152	Helix-turn-helix domain; Region: HTH_28; pfam13518
634458008153	Homeodomain-like domain; Region: HTH_32; pfam13565
634458008154	Integrase core domain; Region: rve; pfam00665
634458008155	Integrase core domain; Region: rve_3; cl15866
634458008156	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
634458008157	Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842
634458008158	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458008159	multiple promoter invertase; Provisional; Region: mpi; PRK13413
634458008160	catalytic residues [active]
634458008161	catalytic nucleophile [active]
634458008162	Presynaptic Site I dimer interface [polypeptide binding]; other site
634458008163	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634458008164	Synaptic Flat tetramer interface [polypeptide binding]; other site
634458008165	Synaptic Site I dimer interface [polypeptide binding]; other site
634458008166	DNA binding site [nucleotide binding]
634458008167	ParA-like protein; Provisional; Region: PHA02518
634458008168	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634458008169	P-loop; other site
634458008170	Magnesium ion binding site [ion binding]; other site
634458008171	Replication initiator protein A; Region: RPA; pfam10134
634458008172	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
634458008173	putative addiction module antidote; Region: doc_partner; TIGR02609
634458008174	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
634458008175	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
634458008176	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
634458008177	putative active site [active]
634458008178	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
634458008179	Conjugal transfer protein TraD; Region: TraD; pfam06412
634458008180	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
634458008181	MobA/MobL family; Region: MobA_MobL; pfam03389
634458008182	AAA domain; Region: AAA_30; pfam13604
634458008183	Family description; Region: UvrD_C_2; pfam13538
634458008184	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
634458008185	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
634458008186	oligomeric interface; other site
634458008187	putative active site [active]
634458008188	homodimer interface [polypeptide binding]; other site
634458008189	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
634458008190	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458008191	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634458008192	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458008193	catalytic residues [active]
634458008194	catalytic nucleophile [active]
634458008195	AAA domain; Region: AAA_31; pfam13614
634458008196	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634458008197	P-loop; other site
634458008198	Magnesium ion binding site [ion binding]; other site
634458008199	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
634458008200	non-specific DNA binding site [nucleotide binding]; other site
634458008201	salt bridge; other site
634458008202	sequence-specific DNA binding site [nucleotide binding]; other site
634458008203	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
634458008204	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
634458008205	HTH-like domain; Region: HTH_21; pfam13276
634458008206	Integrase core domain; Region: rve; pfam00665
634458008207	Integrase core domain; Region: rve_3; pfam13683
634458008208	Transposase; Region: HTH_Tnp_1; pfam01527
634458008209	T5orf172 domain; Region: T5orf172; pfam10544
634458008210	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
634458008211	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
634458008212	Pseudomurein-binding repeat; Region: PMBR; pfam09373
634458008213	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
634458008214	Methyltransferase domain; Region: Methyltransf_26; pfam13659
634458008215	Fic family protein [Function unknown]; Region: COG3177
634458008216	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
634458008217	Fic/DOC family; Region: Fic; pfam02661
634458008218	PemK-like protein; Region: PemK; pfam02452
634458008219	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
634458008220	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
634458008221	Presynaptic Site I dimer interface [polypeptide binding]; other site
634458008222	catalytic residues [active]
634458008223	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
634458008224	Synaptic Flat tetramer interface [polypeptide binding]; other site
634458008225	Synaptic Site I dimer interface [polypeptide binding]; other site
634458008226	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
634458008227	DNA-binding interface [nucleotide binding]; DNA binding site
634458008228	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
634458008229	Hint domain; Region: Hint_2; pfam13403
634458008230	Transposase; Region: HTH_Tnp_1; pfam01527
634458008231	HTH-like domain; Region: HTH_21; pfam13276
634458008232	Integrase core domain; Region: rve; pfam00665
634458008233	Integrase core domain; Region: rve_3; pfam13683
634458008234	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
634458008235	non-specific DNA binding site [nucleotide binding]; other site
634458008236	salt bridge; other site
634458008237	sequence-specific DNA binding site [nucleotide binding]; other site
634458008238	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
634458008239	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
634458008240	P-loop; other site
634458008241	Magnesium ion binding site [ion binding]; other site