-- dump date   	20140618_183455
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1266844000001	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844000002	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844000003	oxidoreductase; Provisional; Region: PRK06196
1266844000004	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1266844000005	putative NAD(P) binding site [chemical binding]; other site
1266844000006	active site
1266844000007	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1266844000008	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1266844000009	putative active site [active]
1266844000010	putative metal binding site [ion binding]; other site
1266844000011	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266844000012	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1266844000013	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266844000014	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1266844000015	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844000016	NAD(P) binding site [chemical binding]; other site
1266844000017	active site
1266844000018	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1266844000019	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1266844000020	FMN binding site [chemical binding]; other site
1266844000021	active site
1266844000022	substrate binding site [chemical binding]; other site
1266844000023	catalytic residue [active]
1266844000024	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1266844000025	MFS/sugar transport protein; Region: MFS_2; pfam13347
1266844000026	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1266844000027	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1266844000028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844000029	putative substrate translocation pore; other site
1266844000030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844000031	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844000032	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844000033	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1266844000034	dimerization interface [polypeptide binding]; other site
1266844000035	substrate binding pocket [chemical binding]; other site
1266844000036	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1266844000037	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1266844000038	DNA-binding site [nucleotide binding]; DNA binding site
1266844000039	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844000040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844000041	homodimer interface [polypeptide binding]; other site
1266844000042	catalytic residue [active]
1266844000043	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
1266844000044	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1266844000045	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
1266844000046	putative active site [active]
1266844000047	catalytic triad [active]
1266844000048	putative dimer interface [polypeptide binding]; other site
1266844000049	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
1266844000050	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844000051	FeS/SAM binding site; other site
1266844000052	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1266844000053	Coenzyme A binding pocket [chemical binding]; other site
1266844000054	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
1266844000055	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
1266844000056	dimerization interface [polypeptide binding]; other site
1266844000057	putative ATP binding site [chemical binding]; other site
1266844000058	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
1266844000059	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1266844000060	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1266844000061	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
1266844000062	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1266844000063	acyl-activating enzyme (AAE) consensus motif; other site
1266844000064	AMP binding site [chemical binding]; other site
1266844000065	active site
1266844000066	CoA binding site [chemical binding]; other site
1266844000067	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844000068	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1266844000069	NAD(P) binding site [chemical binding]; other site
1266844000070	active site
1266844000071	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844000072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844000073	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1266844000074	putative effector binding pocket; other site
1266844000075	putative dimerization interface [polypeptide binding]; other site
1266844000076	Predicted permeases [General function prediction only]; Region: COG0679
1266844000077	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1266844000078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844000079	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1266844000080	dimerization interface [polypeptide binding]; other site
1266844000081	substrate binding pocket [chemical binding]; other site
1266844000082	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1266844000083	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1266844000084	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1266844000085	dimerization interface [polypeptide binding]; other site
1266844000086	putative DNA binding site [nucleotide binding]; other site
1266844000087	putative Zn2+ binding site [ion binding]; other site
1266844000088	AsnC family; Region: AsnC_trans_reg; pfam01037
1266844000089	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1266844000090	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1266844000091	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
1266844000092	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
1266844000093	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1266844000094	active site
1266844000095	substrate binding site [chemical binding]; other site
1266844000096	Mg2+ binding site [ion binding]; other site
1266844000097	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
1266844000098	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1266844000099	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1266844000100	catalytic residues [active]
1266844000101	catalytic nucleophile [active]
1266844000102	Presynaptic Site I dimer interface [polypeptide binding]; other site
1266844000103	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1266844000104	Synaptic Flat tetramer interface [polypeptide binding]; other site
1266844000105	Synaptic Site I dimer interface [polypeptide binding]; other site
1266844000106	DNA binding site [nucleotide binding]
1266844000107	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1266844000108	DNA-binding interface [nucleotide binding]; DNA binding site
1266844000109	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1266844000110	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1266844000111	putative active site [active]
1266844000112	putative NTP binding site [chemical binding]; other site
1266844000113	putative nucleic acid binding site [nucleotide binding]; other site
1266844000114	Predicted helicase [General function prediction only]; Region: COG4889
1266844000115	Predicted helicase [General function prediction only]; Region: COG4889
1266844000116	Predicted helicase [General function prediction only]; Region: COG4889
1266844000117	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844000118	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844000119	Predicted helicase [General function prediction only]; Region: COG4889
1266844000120	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1266844000121	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844000122	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1266844000123	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1266844000124	iron-sulfur cluster [ion binding]; other site
1266844000125	[2Fe-2S] cluster binding site [ion binding]; other site
1266844000126	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
1266844000127	methionine synthase; Provisional; Region: PRK01207
1266844000128	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1266844000129	substrate binding site [chemical binding]; other site
1266844000130	THF binding site; other site
1266844000131	zinc-binding site [ion binding]; other site
1266844000132	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844000133	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844000134	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1266844000135	putative dimerization interface [polypeptide binding]; other site
1266844000136	Putative transposase; Region: Y2_Tnp; pfam04986
1266844000137	Integrase core domain; Region: rve; pfam00665
1266844000138	Integrase core domain; Region: rve_3; cl15866
1266844000139	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1266844000140	YCII-related domain; Region: YCII; pfam03795
1266844000141	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844000142	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844000143	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1266844000144	putative effector binding pocket; other site
1266844000145	dimerization interface [polypeptide binding]; other site
1266844000146	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1266844000147	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844000148	NAD(P) binding site [chemical binding]; other site
1266844000149	active site
1266844000150	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1266844000151	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266844000152	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266844000153	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
1266844000154	Transcriptional regulator; Region: Rrf2; pfam02082
1266844000155	Predicted transcriptional regulator [Transcription]; Region: COG1959
1266844000156	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1266844000157	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
1266844000158	putative ion selectivity filter; other site
1266844000159	putative pore gating glutamate residue; other site
1266844000160	putative H+/Cl- coupling transport residue; other site
1266844000161	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1266844000162	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844000163	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844000164	putative transposase OrfB; Reviewed; Region: PHA02517
1266844000165	HTH-like domain; Region: HTH_21; pfam13276
1266844000166	Integrase core domain; Region: rve; pfam00665
1266844000167	Integrase core domain; Region: rve_3; cl15866
1266844000168	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1266844000169	Transposase; Region: HTH_Tnp_1; cl17663
1266844000170	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1266844000171	putative active site [active]
1266844000172	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
1266844000173	PLD-like domain; Region: PLDc_2; pfam13091
1266844000174	homodimer interface [polypeptide binding]; other site
1266844000175	putative active site [active]
1266844000176	catalytic site [active]
1266844000177	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
1266844000178	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1266844000179	oligomeric interface; other site
1266844000180	putative active site [active]
1266844000181	homodimer interface [polypeptide binding]; other site
1266844000182	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1266844000183	Protein of unknown function (DUF497); Region: DUF497; pfam04365
1266844000184	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
1266844000185	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
1266844000186	Integrase core domain; Region: rve; pfam00665
1266844000187	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1266844000188	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1266844000189	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1266844000190	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1266844000191	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1266844000192	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1266844000193	Cu(I) binding site [ion binding]; other site
1266844000194	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1266844000195	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1266844000196	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1266844000197	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844000198	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844000199	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1266844000200	S-formylglutathione hydrolase; Region: PLN02442
1266844000201	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1266844000202	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266844000203	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1266844000204	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1266844000205	substrate binding site [chemical binding]; other site
1266844000206	catalytic Zn binding site [ion binding]; other site
1266844000207	NAD binding site [chemical binding]; other site
1266844000208	structural Zn binding site [ion binding]; other site
1266844000209	dimer interface [polypeptide binding]; other site
1266844000210	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1266844000211	putative metal binding site [ion binding]; other site
1266844000212	putative homodimer interface [polypeptide binding]; other site
1266844000213	putative homotetramer interface [polypeptide binding]; other site
1266844000214	putative homodimer-homodimer interface [polypeptide binding]; other site
1266844000215	putative allosteric switch controlling residues; other site
1266844000216	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266844000217	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266844000218	active site
1266844000219	catalytic tetrad [active]
1266844000220	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266844000221	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266844000222	active site
1266844000223	catalytic tetrad [active]
1266844000224	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844000225	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844000226	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1266844000227	putative effector binding pocket; other site
1266844000228	putative dimerization interface [polypeptide binding]; other site
1266844000229	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
1266844000230	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266844000231	active site
1266844000232	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1266844000233	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
1266844000234	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1266844000235	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266844000236	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1266844000237	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1266844000238	DNA binding site [nucleotide binding]
1266844000239	active site
1266844000240	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
1266844000241	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
1266844000242	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
1266844000243	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1266844000244	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1266844000245	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1266844000246	catalytic residues [active]
1266844000247	catalytic nucleophile [active]
1266844000248	Presynaptic Site I dimer interface [polypeptide binding]; other site
1266844000249	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1266844000250	Synaptic Flat tetramer interface [polypeptide binding]; other site
1266844000251	Synaptic Site I dimer interface [polypeptide binding]; other site
1266844000252	DNA binding site [nucleotide binding]
1266844000253	AAA domain; Region: AAA_23; pfam13476
1266844000254	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844000255	Walker A/P-loop; other site
1266844000256	ATP binding site [chemical binding]; other site
1266844000257	AAA domain; Region: AAA_21; pfam13304
1266844000258	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844000259	ABC transporter signature motif; other site
1266844000260	Walker B; other site
1266844000261	D-loop; other site
1266844000262	H-loop/switch region; other site
1266844000263	Integrase core domain; Region: rve; pfam00665
1266844000264	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1266844000265	Bacterial TniB protein; Region: TniB; pfam05621
1266844000266	AAA domain; Region: AAA_22; pfam13401
1266844000267	Predicted transcriptional regulator [Transcription]; Region: COG4190
1266844000268	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
1266844000269	Secretin and TonB N terminus short domain; Region: STN; smart00965
1266844000270	Fic/DOC family; Region: Fic; cl00960
1266844000271	replication initiation protein RepC; Provisional; Region: PRK13824
1266844000272	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1266844000273	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
1266844000274	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1266844000275	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1266844000276	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1266844000277	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1266844000278	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1266844000279	GTP cyclohydrolase I; Provisional; Region: PLN03044
1266844000280	active site
1266844000281	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
1266844000282	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1266844000283	metal binding site 2 [ion binding]; metal-binding site
1266844000284	putative DNA binding helix; other site
1266844000285	metal binding site 1 [ion binding]; metal-binding site
1266844000286	dimer interface [polypeptide binding]; other site
1266844000287	structural Zn2+ binding site [ion binding]; other site
1266844000288	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1266844000289	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1266844000290	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1266844000291	dimer interface [polypeptide binding]; other site
1266844000292	active site
1266844000293	motif 1; other site
1266844000294	motif 2; other site
1266844000295	motif 3; other site
1266844000296	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1266844000297	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1266844000298	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1266844000299	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844000300	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844000301	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1266844000302	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1266844000303	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1266844000304	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1266844000305	Integrase core domain; Region: rve; pfam00665
1266844000306	Integrase core domain; Region: rve_3; cl15866
1266844000307	HTH-like domain; Region: HTH_21; pfam13276
1266844000308	Integrase core domain; Region: rve; pfam00665
1266844000309	Integrase core domain; Region: rve_3; cl15866
1266844000310	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1266844000311	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1266844000312	Transposase; Region: HTH_Tnp_1; cl17663
1266844000313	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1266844000314	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1266844000315	catalytic residue [active]
1266844000316	Transposase domain (DUF772); Region: DUF772; pfam05598
1266844000317	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844000318	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1266844000319	104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449
1266844000320	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1266844000321	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844000322	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
1266844000323	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
1266844000324	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1266844000325	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1266844000326	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
1266844000327	PemK-like protein; Region: PemK; cl00995
1266844000328	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
1266844000329	PLD-like domain; Region: PLDc_2; pfam13091
1266844000330	homodimer interface [polypeptide binding]; other site
1266844000331	putative active site [active]
1266844000332	catalytic site [active]
1266844000333	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1266844000334	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1266844000335	catalytic residues [active]
1266844000336	catalytic nucleophile [active]
1266844000337	Presynaptic Site I dimer interface [polypeptide binding]; other site
1266844000338	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1266844000339	Synaptic Flat tetramer interface [polypeptide binding]; other site
1266844000340	Synaptic Site I dimer interface [polypeptide binding]; other site
1266844000341	DNA binding site [nucleotide binding]
1266844000342	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1266844000343	DNA-binding interface [nucleotide binding]; DNA binding site
1266844000344	Hint domain; Region: Hint_2; pfam13403
1266844000345	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844000346	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844000347	Hint domain; Region: Hint_2; pfam13403
1266844000348	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
1266844000349	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
1266844000350	RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127
1266844000351	Uncharacterized protein family (UPF0258); Region: UPF0258; pfam06789
1266844000352	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
1266844000353	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1266844000354	TrwC relaxase; Region: TrwC; pfam08751
1266844000355	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
1266844000356	AAA domain; Region: AAA_30; pfam13604
1266844000357	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
1266844000358	Hint domain; Region: Hint_2; pfam13403
1266844000359	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1266844000360	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1266844000361	catalytic residues [active]
1266844000362	catalytic nucleophile [active]
1266844000363	Presynaptic Site I dimer interface [polypeptide binding]; other site
1266844000364	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1266844000365	Synaptic Flat tetramer interface [polypeptide binding]; other site
1266844000366	Synaptic Site I dimer interface [polypeptide binding]; other site
1266844000367	DNA binding site [nucleotide binding]
1266844000368	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1266844000369	DNA-binding interface [nucleotide binding]; DNA binding site
1266844000370	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
1266844000371	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1266844000372	IHF dimer interface [polypeptide binding]; other site
1266844000373	IHF - DNA interface [nucleotide binding]; other site
1266844000374	Prophage antirepressor [Transcription]; Region: COG3617
1266844000375	BRO family, N-terminal domain; Region: Bro-N; smart01040
1266844000376	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1266844000377	oligomeric interface; other site
1266844000378	putative active site [active]
1266844000379	homodimer interface [polypeptide binding]; other site
1266844000380	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1266844000381	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1266844000382	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1266844000383	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1266844000384	dimer interface [polypeptide binding]; other site
1266844000385	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
1266844000386	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
1266844000387	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844000388	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1266844000389	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
1266844000390	Protein of unknown function (DUF497); Region: DUF497; cl01108
1266844000391	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844000392	non-specific DNA binding site [nucleotide binding]; other site
1266844000393	salt bridge; other site
1266844000394	sequence-specific DNA binding site [nucleotide binding]; other site
1266844000395	plasmid partitioning protein; Provisional; Region: PRK13832
1266844000396	ParB-like nuclease domain; Region: ParBc; pfam02195
1266844000397	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1266844000398	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844000399	S-adenosylmethionine binding site [chemical binding]; other site
1266844000400	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1266844000401	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1266844000402	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1266844000403	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1266844000404	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
1266844000405	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266844000406	active site
1266844000407	DNA binding site [nucleotide binding]
1266844000408	Int/Topo IB signature motif; other site
1266844000409	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1266844000410	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
1266844000411	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1266844000412	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1266844000413	putative dimer interface [polypeptide binding]; other site
1266844000414	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1266844000415	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1266844000416	active site
1266844000417	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1266844000418	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
1266844000419	putative active site [active]
1266844000420	putative PHP Thumb interface [polypeptide binding]; other site
1266844000421	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1266844000422	generic binding surface II; other site
1266844000423	generic binding surface I; other site
1266844000424	DNA Polymerase Y-family; Region: PolY_like; cd03468
1266844000425	active site
1266844000426	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1266844000427	DNA binding site [nucleotide binding]
1266844000428	Uncharacterized conserved protein [Function unknown]; Region: COG4544
1266844000429	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1266844000430	Part of AAA domain; Region: AAA_19; pfam13245
1266844000431	Family description; Region: UvrD_C_2; pfam13538
1266844000432	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844000433	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844000434	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1266844000435	putative hydrophobic ligand binding site [chemical binding]; other site
1266844000436	protein interface [polypeptide binding]; other site
1266844000437	gate; other site
1266844000438	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1266844000439	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844000440	NAD(P) binding site [chemical binding]; other site
1266844000441	active site
1266844000442	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844000443	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844000444	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844000445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844000446	NAD(P) binding site [chemical binding]; other site
1266844000447	active site
1266844000448	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1266844000449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844000450	putative substrate translocation pore; other site
1266844000451	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1266844000452	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844000453	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844000454	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1266844000455	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
1266844000456	putative C-terminal domain interface [polypeptide binding]; other site
1266844000457	putative GSH binding site (G-site) [chemical binding]; other site
1266844000458	putative dimer interface [polypeptide binding]; other site
1266844000459	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
1266844000460	putative N-terminal domain interface [polypeptide binding]; other site
1266844000461	putative dimer interface [polypeptide binding]; other site
1266844000462	putative substrate binding pocket (H-site) [chemical binding]; other site
1266844000463	Hint domain; Region: Hint_2; pfam13403
1266844000464	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1266844000465	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
1266844000466	DNA binding site [nucleotide binding]
1266844000467	dimer interface [polypeptide binding]; other site
1266844000468	active site
1266844000469	Int/Topo IB signature motif; other site
1266844000470	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844000471	salt bridge; other site
1266844000472	non-specific DNA binding site [nucleotide binding]; other site
1266844000473	sequence-specific DNA binding site [nucleotide binding]; other site
1266844000474	Hint domain; Region: Hint_2; pfam13403
1266844000475	Helix-turn-helix domain; Region: HTH_36; pfam13730
1266844000476	Hint domain; Region: Hint_2; pfam13403
1266844000477	Predicted transcriptional regulator [Transcription]; Region: COG3905
1266844000478	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1266844000479	non-specific DNA interactions [nucleotide binding]; other site
1266844000480	DNA binding site [nucleotide binding]
1266844000481	sequence specific DNA binding site [nucleotide binding]; other site
1266844000482	putative cAMP binding site [chemical binding]; other site
1266844000483	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1266844000484	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1266844000485	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1266844000486	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1266844000487	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1266844000488	Integrase core domain; Region: rve; pfam00665
1266844000489	hypothetical protein; Provisional; Region: PRK09945
1266844000490	Hint domain; Region: Hint_2; pfam13403
1266844000491	Integrase core domain; Region: rve_3; pfam13683
1266844000492	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1266844000493	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1266844000494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844000495	Walker A motif; other site
1266844000496	ATP binding site [chemical binding]; other site
1266844000497	Walker B motif; other site
1266844000498	arginine finger; other site
1266844000499	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1266844000500	DnaA box-binding interface [nucleotide binding]; other site
1266844000501	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1266844000502	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1266844000503	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1266844000504	DNA binding site [nucleotide binding]
1266844000505	catalytic residue [active]
1266844000506	H2TH interface [polypeptide binding]; other site
1266844000507	putative catalytic residues [active]
1266844000508	turnover-facilitating residue; other site
1266844000509	intercalation triad [nucleotide binding]; other site
1266844000510	8OG recognition residue [nucleotide binding]; other site
1266844000511	putative reading head residues; other site
1266844000512	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1266844000513	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1266844000514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844000515	S-adenosylmethionine binding site [chemical binding]; other site
1266844000516	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1266844000517	Flavoprotein; Region: Flavoprotein; pfam02441
1266844000518	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1266844000519	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1266844000520	trimer interface [polypeptide binding]; other site
1266844000521	active site
1266844000522	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
1266844000523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844000524	dimer interface [polypeptide binding]; other site
1266844000525	conserved gate region; other site
1266844000526	putative PBP binding loops; other site
1266844000527	ABC-ATPase subunit interface; other site
1266844000528	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1266844000529	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1266844000530	Walker A/P-loop; other site
1266844000531	ATP binding site [chemical binding]; other site
1266844000532	Q-loop/lid; other site
1266844000533	ABC transporter signature motif; other site
1266844000534	Walker B; other site
1266844000535	D-loop; other site
1266844000536	H-loop/switch region; other site
1266844000537	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
1266844000538	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1266844000539	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1266844000540	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1266844000541	HIGH motif; other site
1266844000542	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1266844000543	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1266844000544	active site
1266844000545	KMSKS motif; other site
1266844000546	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1266844000547	tRNA binding surface [nucleotide binding]; other site
1266844000548	anticodon binding site; other site
1266844000549	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1266844000550	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
1266844000551	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1266844000552	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1266844000553	Hint domain; Region: Hint_2; pfam13403
1266844000554	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1266844000555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844000556	NAD(P) binding site [chemical binding]; other site
1266844000557	active site
1266844000558	thiamine monophosphate kinase; Provisional; Region: PRK05731
1266844000559	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1266844000560	ATP binding site [chemical binding]; other site
1266844000561	dimerization interface [polypeptide binding]; other site
1266844000562	transcription antitermination factor NusB; Region: nusB; TIGR01951
1266844000563	putative RNA binding site [nucleotide binding]; other site
1266844000564	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1266844000565	ATP cone domain; Region: ATP-cone; pfam03477
1266844000566	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1266844000567	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1266844000568	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1266844000569	N- and C-terminal domain interface [polypeptide binding]; other site
1266844000570	active site
1266844000571	MgATP binding site [chemical binding]; other site
1266844000572	catalytic site [active]
1266844000573	metal binding site [ion binding]; metal-binding site
1266844000574	glycerol binding site [chemical binding]; other site
1266844000575	homotetramer interface [polypeptide binding]; other site
1266844000576	homodimer interface [polypeptide binding]; other site
1266844000577	FBP binding site [chemical binding]; other site
1266844000578	protein IIAGlc interface [polypeptide binding]; other site
1266844000579	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1266844000580	amphipathic channel; other site
1266844000581	Asn-Pro-Ala signature motifs; other site
1266844000582	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1266844000583	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1266844000584	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1266844000585	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1266844000586	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1266844000587	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266844000588	ATP binding site [chemical binding]; other site
1266844000589	putative Mg++ binding site [ion binding]; other site
1266844000590	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844000591	nucleotide binding region [chemical binding]; other site
1266844000592	ATP-binding site [chemical binding]; other site
1266844000593	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1266844000594	HRDC domain; Region: HRDC; pfam00570
1266844000595	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
1266844000596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844000597	Walker A/P-loop; other site
1266844000598	ATP binding site [chemical binding]; other site
1266844000599	Q-loop/lid; other site
1266844000600	ABC transporter signature motif; other site
1266844000601	Walker B; other site
1266844000602	D-loop; other site
1266844000603	H-loop/switch region; other site
1266844000604	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
1266844000605	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844000606	Walker A/P-loop; other site
1266844000607	ATP binding site [chemical binding]; other site
1266844000608	Q-loop/lid; other site
1266844000609	ABC transporter signature motif; other site
1266844000610	Walker B; other site
1266844000611	D-loop; other site
1266844000612	H-loop/switch region; other site
1266844000613	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1266844000614	Histidine kinase; Region: HisKA_2; pfam07568
1266844000615	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844000616	ATP binding site [chemical binding]; other site
1266844000617	Mg2+ binding site [ion binding]; other site
1266844000618	G-X-G motif; other site
1266844000619	RNA polymerase sigma factor; Provisional; Region: PRK12547
1266844000620	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1266844000621	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1266844000622	DNA binding residues [nucleotide binding]
1266844000623	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1266844000624	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1266844000625	DNA binding residues [nucleotide binding]
1266844000626	two-component response regulator; Provisional; Region: PRK09191
1266844000627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844000628	active site
1266844000629	phosphorylation site [posttranslational modification]
1266844000630	intermolecular recognition site; other site
1266844000631	dimerization interface [polypeptide binding]; other site
1266844000632	ABC transporter ATPase component; Reviewed; Region: PRK11147
1266844000633	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266844000634	ABC transporter; Region: ABC_tran_2; pfam12848
1266844000635	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266844000636	trehalase; Provisional; Region: treF; PRK13270
1266844000637	Trehalase; Region: Trehalase; cl17346
1266844000638	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1266844000639	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1266844000640	substrate binding site [chemical binding]; other site
1266844000641	catalytic Zn binding site [ion binding]; other site
1266844000642	NAD binding site [chemical binding]; other site
1266844000643	structural Zn binding site [ion binding]; other site
1266844000644	dimer interface [polypeptide binding]; other site
1266844000645	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1266844000646	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1266844000647	PhnA protein; Region: PhnA; pfam03831
1266844000648	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1266844000649	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1266844000650	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1266844000651	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1266844000652	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1266844000653	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1266844000654	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1266844000655	amidohydrolase; Provisional; Region: PRK12393
1266844000656	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1266844000657	active site
1266844000658	putative substrate binding pocket [chemical binding]; other site
1266844000659	NMT1/THI5 like; Region: NMT1; pfam09084
1266844000660	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
1266844000661	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1266844000662	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1266844000663	Walker A/P-loop; other site
1266844000664	ATP binding site [chemical binding]; other site
1266844000665	Q-loop/lid; other site
1266844000666	ABC transporter signature motif; other site
1266844000667	Walker B; other site
1266844000668	D-loop; other site
1266844000669	H-loop/switch region; other site
1266844000670	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1266844000671	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844000672	dimer interface [polypeptide binding]; other site
1266844000673	conserved gate region; other site
1266844000674	putative PBP binding loops; other site
1266844000675	ABC-ATPase subunit interface; other site
1266844000676	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
1266844000677	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1266844000678	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1266844000679	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
1266844000680	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1266844000681	active site
1266844000682	putative substrate binding pocket [chemical binding]; other site
1266844000683	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1266844000684	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844000685	allantoate amidohydrolase; Reviewed; Region: PRK09290
1266844000686	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1266844000687	active site
1266844000688	metal binding site [ion binding]; metal-binding site
1266844000689	dimer interface [polypeptide binding]; other site
1266844000690	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1266844000691	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1266844000692	catalytic residue [active]
1266844000693	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
1266844000694	SnoaL-like domain; Region: SnoaL_3; pfam13474
1266844000695	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
1266844000696	amidase; Provisional; Region: PRK09201
1266844000697	Amidase; Region: Amidase; pfam01425
1266844000698	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1266844000699	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
1266844000700	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1266844000701	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
1266844000702	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1266844000703	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1266844000704	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
1266844000705	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1266844000706	catalytic loop [active]
1266844000707	iron binding site [ion binding]; other site
1266844000708	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1266844000709	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1266844000710	xanthine permease; Region: pbuX; TIGR03173
1266844000711	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1266844000712	active site
1266844000713	homotetramer interface [polypeptide binding]; other site
1266844000714	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
1266844000715	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1266844000716	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1266844000717	active site
1266844000718	catalytic site [active]
1266844000719	tetramer interface [polypeptide binding]; other site
1266844000720	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1266844000721	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1266844000722	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844000723	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844000724	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1266844000725	dimerization interface [polypeptide binding]; other site
1266844000726	guanine deaminase; Provisional; Region: PRK09228
1266844000727	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1266844000728	active site
1266844000729	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1266844000730	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1266844000731	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1266844000732	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1266844000733	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1266844000734	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1266844000735	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1266844000736	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1266844000737	Rdx family; Region: Rdx; cl01407
1266844000738	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1266844000739	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1266844000740	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844000741	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1266844000742	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1266844000743	Walker A/P-loop; other site
1266844000744	ATP binding site [chemical binding]; other site
1266844000745	Q-loop/lid; other site
1266844000746	ABC transporter signature motif; other site
1266844000747	Walker B; other site
1266844000748	D-loop; other site
1266844000749	H-loop/switch region; other site
1266844000750	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844000751	Walker A/P-loop; other site
1266844000752	ATP binding site [chemical binding]; other site
1266844000753	Q-loop/lid; other site
1266844000754	ABC transporter signature motif; other site
1266844000755	Walker B; other site
1266844000756	D-loop; other site
1266844000757	H-loop/switch region; other site
1266844000758	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1266844000759	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1266844000760	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1266844000761	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1266844000762	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1266844000763	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844000764	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844000765	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1266844000766	putative dimerization interface [polypeptide binding]; other site
1266844000767	Predicted membrane protein [Function unknown]; Region: COG2855
1266844000768	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
1266844000769	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
1266844000770	Active site cavity [active]
1266844000771	catalytic acid [active]
1266844000772	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844000773	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844000774	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844000775	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844000776	WHG domain; Region: WHG; pfam13305
1266844000777	Secretory lipase; Region: LIP; pfam03583
1266844000778	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
1266844000779	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1266844000780	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1266844000781	NAD(P) binding site [chemical binding]; other site
1266844000782	catalytic residues [active]
1266844000783	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1266844000784	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1266844000785	FMN binding site [chemical binding]; other site
1266844000786	active site
1266844000787	substrate binding site [chemical binding]; other site
1266844000788	catalytic residue [active]
1266844000789	Predicted transcriptional regulators [Transcription]; Region: COG1733
1266844000790	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1266844000791	hydroperoxidase II; Provisional; Region: katE; PRK11249
1266844000792	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1266844000793	heme binding pocket [chemical binding]; other site
1266844000794	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1266844000795	domain interactions; other site
1266844000796	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1266844000797	hypothetical protein; Provisional; Region: PRK09256
1266844000798	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1266844000799	Putative glucoamylase; Region: Glycoamylase; pfam10091
1266844000800	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
1266844000801	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
1266844000802	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
1266844000803	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1266844000804	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1266844000805	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1266844000806	active site
1266844000807	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1266844000808	dimer interface [polypeptide binding]; other site
1266844000809	substrate binding site [chemical binding]; other site
1266844000810	ATP binding site [chemical binding]; other site
1266844000811	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1266844000812	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844000813	N-terminal plug; other site
1266844000814	ligand-binding site [chemical binding]; other site
1266844000815	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1266844000816	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1266844000817	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1266844000818	Protein of unknown function DUF72; Region: DUF72; pfam01904
1266844000819	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1266844000820	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1266844000821	putative chaperone; Provisional; Region: PRK11678
1266844000822	nucleotide binding site [chemical binding]; other site
1266844000823	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1266844000824	SBD interface [polypeptide binding]; other site
1266844000825	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1266844000826	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1266844000827	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1266844000828	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844000829	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1266844000830	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844000831	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844000832	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1266844000833	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1266844000834	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1266844000835	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1266844000836	benzoate transport; Region: 2A0115; TIGR00895
1266844000837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844000838	putative substrate translocation pore; other site
1266844000839	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1266844000840	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
1266844000841	active site
1266844000842	hypothetical protein; Provisional; Region: PRK09945
1266844000843	Hint domain; Region: Hint_2; pfam13403
1266844000844	SnoaL-like domain; Region: SnoaL_2; pfam12680
1266844000845	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1266844000846	Helix-turn-helix domain; Region: HTH_18; pfam12833
1266844000847	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266844000848	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1266844000849	putative deacylase active site [active]
1266844000850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844000851	putative substrate translocation pore; other site
1266844000852	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1266844000853	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1266844000854	metal binding site 2 [ion binding]; metal-binding site
1266844000855	putative DNA binding helix; other site
1266844000856	metal binding site 1 [ion binding]; metal-binding site
1266844000857	dimer interface [polypeptide binding]; other site
1266844000858	structural Zn2+ binding site [ion binding]; other site
1266844000859	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1266844000860	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1266844000861	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1266844000862	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1266844000863	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1266844000864	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1266844000865	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1266844000866	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1266844000867	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1266844000868	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844000869	N-terminal plug; other site
1266844000870	ligand-binding site [chemical binding]; other site
1266844000871	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1266844000872	FecR protein; Region: FecR; pfam04773
1266844000873	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1266844000874	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
1266844000875	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1266844000876	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1266844000877	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844000878	N-terminal plug; other site
1266844000879	ligand-binding site [chemical binding]; other site
1266844000880	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1266844000881	FecR protein; Region: FecR; pfam04773
1266844000882	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1266844000883	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1266844000884	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1266844000885	DNA binding residues [nucleotide binding]
1266844000886	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1266844000887	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1266844000888	substrate binding pocket [chemical binding]; other site
1266844000889	membrane-bound complex binding site; other site
1266844000890	hinge residues; other site
1266844000891	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1266844000892	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1266844000893	Walker A/P-loop; other site
1266844000894	ATP binding site [chemical binding]; other site
1266844000895	Q-loop/lid; other site
1266844000896	ABC transporter signature motif; other site
1266844000897	Walker B; other site
1266844000898	D-loop; other site
1266844000899	H-loop/switch region; other site
1266844000900	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1266844000901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844000902	dimer interface [polypeptide binding]; other site
1266844000903	conserved gate region; other site
1266844000904	putative PBP binding loops; other site
1266844000905	ABC-ATPase subunit interface; other site
1266844000906	Secretory lipase; Region: LIP; pfam03583
1266844000907	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
1266844000908	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1266844000909	active site
1266844000910	iron coordination sites [ion binding]; other site
1266844000911	substrate binding pocket [chemical binding]; other site
1266844000912	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844000913	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844000914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844000915	D-galactonate transporter; Region: 2A0114; TIGR00893
1266844000916	putative substrate translocation pore; other site
1266844000917	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
1266844000918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844000919	D-galactonate transporter; Region: 2A0114; TIGR00893
1266844000920	putative substrate translocation pore; other site
1266844000921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844000922	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1266844000923	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844000924	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
1266844000925	putative dimerization interface [polypeptide binding]; other site
1266844000926	putative substrate binding pocket [chemical binding]; other site
1266844000927	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
1266844000928	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1266844000929	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1266844000930	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1266844000931	active site
1266844000932	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1266844000933	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844000934	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844000935	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1266844000936	dimerization interface [polypeptide binding]; other site
1266844000937	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1266844000938	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1266844000939	active site
1266844000940	NAD binding site [chemical binding]; other site
1266844000941	metal binding site [ion binding]; metal-binding site
1266844000942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844000943	metabolite-proton symporter; Region: 2A0106; TIGR00883
1266844000944	putative substrate translocation pore; other site
1266844000945	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1266844000946	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1266844000947	tetrameric interface [polypeptide binding]; other site
1266844000948	NAD binding site [chemical binding]; other site
1266844000949	catalytic residues [active]
1266844000950	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
1266844000951	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1266844000952	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1266844000953	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844000954	dimer interface [polypeptide binding]; other site
1266844000955	conserved gate region; other site
1266844000956	putative PBP binding loops; other site
1266844000957	ABC-ATPase subunit interface; other site
1266844000958	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1266844000959	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1266844000960	Walker A/P-loop; other site
1266844000961	ATP binding site [chemical binding]; other site
1266844000962	Q-loop/lid; other site
1266844000963	ABC transporter signature motif; other site
1266844000964	Walker B; other site
1266844000965	D-loop; other site
1266844000966	H-loop/switch region; other site
1266844000967	nickel responsive regulator; Provisional; Region: PRK04460
1266844000968	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
1266844000969	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
1266844000970	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1266844000971	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1266844000972	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1266844000973	urea carboxylase; Region: urea_carbox; TIGR02712
1266844000974	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1266844000975	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1266844000976	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1266844000977	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1266844000978	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1266844000979	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1266844000980	carboxyltransferase (CT) interaction site; other site
1266844000981	biotinylation site [posttranslational modification]; other site
1266844000982	allophanate hydrolase; Provisional; Region: PRK08186
1266844000983	Amidase; Region: Amidase; cl11426
1266844000984	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1266844000985	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1266844000986	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
1266844000987	Part of AAA domain; Region: AAA_19; pfam13245
1266844000988	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1266844000989	AAA domain; Region: AAA_30; pfam13604
1266844000990	AAA domain; Region: AAA_12; pfam13087
1266844000991	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1266844000992	putative active site [active]
1266844000993	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
1266844000994	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1266844000995	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1266844000996	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1266844000997	active site
1266844000998	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844000999	N-terminal plug; other site
1266844001000	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1266844001001	ligand-binding site [chemical binding]; other site
1266844001002	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1266844001003	heme binding pocket [chemical binding]; other site
1266844001004	heme ligand [chemical binding]; other site
1266844001005	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1266844001006	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1266844001007	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1266844001008	Walker A/P-loop; other site
1266844001009	ATP binding site [chemical binding]; other site
1266844001010	Q-loop/lid; other site
1266844001011	ABC transporter signature motif; other site
1266844001012	Walker B; other site
1266844001013	D-loop; other site
1266844001014	H-loop/switch region; other site
1266844001015	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1266844001016	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1266844001017	ABC-ATPase subunit  interface; other site
1266844001018	dimer interface [polypeptide binding]; other site
1266844001019	putative PBP binding regions; other site
1266844001020	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
1266844001021	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1266844001022	intersubunit interface [polypeptide binding]; other site
1266844001023	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1266844001024	manganese transport regulator MntR; Provisional; Region: PRK11050
1266844001025	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1266844001026	DNA-binding site [nucleotide binding]; DNA binding site
1266844001027	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1266844001028	manganese transport protein MntH; Reviewed; Region: PRK00701
1266844001029	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1266844001030	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1266844001031	Major royal jelly protein; Region: MRJP; pfam03022
1266844001032	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1266844001033	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1266844001034	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1266844001035	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1266844001036	tyramine oxidase; Provisional; Region: tynA; PRK11504
1266844001037	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
1266844001038	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
1266844001039	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
1266844001040	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1266844001041	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1266844001042	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1266844001043	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1266844001044	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1266844001045	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1266844001046	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1266844001047	FMN binding site [chemical binding]; other site
1266844001048	active site
1266844001049	substrate binding site [chemical binding]; other site
1266844001050	catalytic residue [active]
1266844001051	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1266844001052	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844001053	NAD(P) binding site [chemical binding]; other site
1266844001054	active site
1266844001055	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266844001056	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1266844001057	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266844001058	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1266844001059	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1266844001060	putative active site [active]
1266844001061	putative metal binding site [ion binding]; other site
1266844001062	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844001063	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844001064	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
1266844001065	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1266844001066	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1266844001067	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
1266844001068	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1266844001069	catalytic loop [active]
1266844001070	iron binding site [ion binding]; other site
1266844001071	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1266844001072	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1266844001073	hypothetical protein; Provisional; Region: PRK09945
1266844001074	Hint domain; Region: Hint_2; pfam13403
1266844001075	Hint domain; Region: Hint_2; pfam13403
1266844001076	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1266844001077	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
1266844001078	putative active site [active]
1266844001079	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266844001080	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1266844001081	Walker A/P-loop; other site
1266844001082	ATP binding site [chemical binding]; other site
1266844001083	Q-loop/lid; other site
1266844001084	ABC transporter signature motif; other site
1266844001085	Walker B; other site
1266844001086	D-loop; other site
1266844001087	H-loop/switch region; other site
1266844001088	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1266844001089	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844001090	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1266844001091	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844001092	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844001093	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1266844001094	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1266844001095	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1266844001096	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1266844001097	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844001098	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844001099	Flavin Reductases; Region: FlaRed; cl00801
1266844001100	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1266844001101	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844001102	putative substrate translocation pore; other site
1266844001103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1266844001104	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1266844001105	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1266844001106	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1266844001107	active site
1266844001108	dimer interface [polypeptide binding]; other site
1266844001109	non-prolyl cis peptide bond; other site
1266844001110	insertion regions; other site
1266844001111	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782
1266844001112	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1266844001113	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1266844001114	active site
1266844001115	non-prolyl cis peptide bond; other site
1266844001116	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1266844001117	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1266844001118	active site
1266844001119	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1266844001120	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
1266844001121	putative FMN binding site [chemical binding]; other site
1266844001122	ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049
1266844001123	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844001124	N-terminal plug; other site
1266844001125	ligand-binding site [chemical binding]; other site
1266844001126	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1266844001127	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1266844001128	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1266844001129	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1266844001130	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1266844001131	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
1266844001132	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1266844001133	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1266844001134	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1266844001135	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1266844001136	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1266844001137	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266844001138	ATP binding site [chemical binding]; other site
1266844001139	putative Mg++ binding site [ion binding]; other site
1266844001140	Protein of unknown function DUF45; Region: DUF45; pfam01863
1266844001141	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1266844001142	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844001143	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844001144	Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248
1266844001145	active site
1266844001146	S2 subsite; other site
1266844001147	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844001148	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1266844001149	Walker A motif; other site
1266844001150	ATP binding site [chemical binding]; other site
1266844001151	Walker B motif; other site
1266844001152	arginine finger; other site
1266844001153	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
1266844001154	active site
1266844001155	catalytic triad [active]
1266844001156	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1266844001157	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844001158	Walker A motif; other site
1266844001159	ATP binding site [chemical binding]; other site
1266844001160	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1266844001161	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844001162	S-adenosylmethionine binding site [chemical binding]; other site
1266844001163	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844001164	non-specific DNA binding site [nucleotide binding]; other site
1266844001165	salt bridge; other site
1266844001166	sequence-specific DNA binding site [nucleotide binding]; other site
1266844001167	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1266844001168	Predicted transcriptional regulator [Transcription]; Region: COG2932
1266844001169	Catalytic site [active]
1266844001170	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1266844001171	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1266844001172	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1266844001173	catalytic residues [active]
1266844001174	catalytic nucleophile [active]
1266844001175	Recombinase; Region: Recombinase; pfam07508
1266844001176	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1266844001177	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1266844001178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844001179	Walker A/P-loop; other site
1266844001180	ATP binding site [chemical binding]; other site
1266844001181	Q-loop/lid; other site
1266844001182	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844001183	ABC transporter signature motif; other site
1266844001184	Walker B; other site
1266844001185	D-loop; other site
1266844001186	H-loop/switch region; other site
1266844001187	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844001188	Walker A/P-loop; other site
1266844001189	ATP binding site [chemical binding]; other site
1266844001190	Q-loop/lid; other site
1266844001191	ABC transporter signature motif; other site
1266844001192	Walker B; other site
1266844001193	D-loop; other site
1266844001194	H-loop/switch region; other site
1266844001195	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1266844001196	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1266844001197	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
1266844001198	glutaredoxin 2; Provisional; Region: PRK10387
1266844001199	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
1266844001200	C-terminal domain interface [polypeptide binding]; other site
1266844001201	GSH binding site (G-site) [chemical binding]; other site
1266844001202	catalytic residues [active]
1266844001203	putative dimer interface [polypeptide binding]; other site
1266844001204	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
1266844001205	N-terminal domain interface [polypeptide binding]; other site
1266844001206	polyol permease family; Region: 2A0118; TIGR00897
1266844001207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844001208	putative substrate translocation pore; other site
1266844001209	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1266844001210	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1266844001211	active site
1266844001212	SAM binding site [chemical binding]; other site
1266844001213	homodimer interface [polypeptide binding]; other site
1266844001214	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1266844001215	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1266844001216	active site
1266844001217	putative homodimer interface [polypeptide binding]; other site
1266844001218	SAM binding site [chemical binding]; other site
1266844001219	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1266844001220	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844001221	S-adenosylmethionine binding site [chemical binding]; other site
1266844001222	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1266844001223	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
1266844001224	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1266844001225	active site
1266844001226	SAM binding site [chemical binding]; other site
1266844001227	homodimer interface [polypeptide binding]; other site
1266844001228	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1266844001229	active site
1266844001230	SAM binding site [chemical binding]; other site
1266844001231	homodimer interface [polypeptide binding]; other site
1266844001232	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1266844001233	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1266844001234	precorrin-3B synthase; Region: CobG; TIGR02435
1266844001235	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1266844001236	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1266844001237	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1266844001238	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1266844001239	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1266844001240	Class II fumarases; Region: Fumarase_classII; cd01362
1266844001241	active site
1266844001242	tetramer interface [polypeptide binding]; other site
1266844001243	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1266844001244	GAF domain; Region: GAF; cl17456
1266844001245	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1266844001246	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
1266844001247	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1266844001248	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1266844001249	Trp docking motif [polypeptide binding]; other site
1266844001250	putative active site [active]
1266844001251	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
1266844001252	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1266844001253	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1266844001254	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1266844001255	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1266844001256	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1266844001257	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1266844001258	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1266844001259	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1266844001260	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1266844001261	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
1266844001262	propionate/acetate kinase; Provisional; Region: PRK12379
1266844001263	phosphate acetyltransferase; Provisional; Region: PRK11890
1266844001264	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
1266844001265	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
1266844001266	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1266844001267	phosphate binding site [ion binding]; other site
1266844001268	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1266844001269	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1266844001270	dimer interface [polypeptide binding]; other site
1266844001271	PYR/PP interface [polypeptide binding]; other site
1266844001272	TPP binding site [chemical binding]; other site
1266844001273	substrate binding site [chemical binding]; other site
1266844001274	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1266844001275	Domain of unknown function; Region: EKR; pfam10371
1266844001276	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1266844001277	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1266844001278	TPP-binding site [chemical binding]; other site
1266844001279	dimer interface [polypeptide binding]; other site
1266844001280	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
1266844001281	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1266844001282	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1266844001283	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844001284	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844001285	Predicted membrane protein [Function unknown]; Region: COG1971
1266844001286	Domain of unknown function DUF; Region: DUF204; pfam02659
1266844001287	Domain of unknown function DUF; Region: DUF204; pfam02659
1266844001288	glutathionine S-transferase; Provisional; Region: PRK10542
1266844001289	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1266844001290	C-terminal domain interface [polypeptide binding]; other site
1266844001291	GSH binding site (G-site) [chemical binding]; other site
1266844001292	dimer interface [polypeptide binding]; other site
1266844001293	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1266844001294	dimer interface [polypeptide binding]; other site
1266844001295	N-terminal domain interface [polypeptide binding]; other site
1266844001296	substrate binding pocket (H-site) [chemical binding]; other site
1266844001297	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
1266844001298	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1266844001299	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1266844001300	GTP binding site; other site
1266844001301	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1266844001302	Walker A motif; other site
1266844001303	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1266844001304	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1266844001305	dimer interface [polypeptide binding]; other site
1266844001306	putative functional site; other site
1266844001307	putative MPT binding site; other site
1266844001308	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
1266844001309	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
1266844001310	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1266844001311	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1266844001312	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
1266844001313	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
1266844001314	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
1266844001315	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1266844001316	[4Fe-4S] binding site [ion binding]; other site
1266844001317	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1266844001318	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1266844001319	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1266844001320	molybdopterin cofactor binding site; other site
1266844001321	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1266844001322	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1266844001323	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1266844001324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844001325	S-adenosylmethionine binding site [chemical binding]; other site
1266844001326	fructokinase; Reviewed; Region: PRK09557
1266844001327	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1266844001328	nucleotide binding site [chemical binding]; other site
1266844001329	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1266844001330	CPxP  motif; other site
1266844001331	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1266844001332	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1266844001333	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1266844001334	substrate binding pocket [chemical binding]; other site
1266844001335	chain length determination region; other site
1266844001336	substrate-Mg2+ binding site; other site
1266844001337	catalytic residues [active]
1266844001338	aspartate-rich region 1; other site
1266844001339	active site lid residues [active]
1266844001340	aspartate-rich region 2; other site
1266844001341	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1266844001342	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1266844001343	TPP-binding site; other site
1266844001344	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1266844001345	PYR/PP interface [polypeptide binding]; other site
1266844001346	dimer interface [polypeptide binding]; other site
1266844001347	TPP binding site [chemical binding]; other site
1266844001348	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1266844001349	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1266844001350	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1266844001351	RNA binding surface [nucleotide binding]; other site
1266844001352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844001353	S-adenosylmethionine binding site [chemical binding]; other site
1266844001354	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
1266844001355	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844001356	FeS/SAM binding site; other site
1266844001357	argininosuccinate synthase; Provisional; Region: PRK13820
1266844001358	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1266844001359	ANP binding site [chemical binding]; other site
1266844001360	Substrate Binding Site II [chemical binding]; other site
1266844001361	Substrate Binding Site I [chemical binding]; other site
1266844001362	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1266844001363	Cytochrome c; Region: Cytochrom_C; pfam00034
1266844001364	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1266844001365	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1266844001366	active site
1266844001367	HIGH motif; other site
1266844001368	dimer interface [polypeptide binding]; other site
1266844001369	KMSKS motif; other site
1266844001370	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1266844001371	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542
1266844001372	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
1266844001373	Phage protein GP46; Region: GP46; pfam07409
1266844001374	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
1266844001375	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1266844001376	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
1266844001377	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
1266844001378	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
1266844001379	Phage tail tube protein; Region: Tail_tube; pfam10618
1266844001380	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
1266844001381	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
1266844001382	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
1266844001383	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
1266844001384	Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924
1266844001385	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
1266844001386	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1266844001387	tandem repeat interface [polypeptide binding]; other site
1266844001388	oligomer interface [polypeptide binding]; other site
1266844001389	active site residues [active]
1266844001390	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
1266844001391	Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136
1266844001392	gpW; Region: gpW; pfam02831
1266844001393	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
1266844001394	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
1266844001395	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1266844001396	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266844001397	active site
1266844001398	DNA binding site [nucleotide binding]
1266844001399	Int/Topo IB signature motif; other site
1266844001400	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844001401	non-specific DNA binding site [nucleotide binding]; other site
1266844001402	salt bridge; other site
1266844001403	sequence-specific DNA binding site [nucleotide binding]; other site
1266844001404	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
1266844001405	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266844001406	active site
1266844001407	DNA binding site [nucleotide binding]
1266844001408	Int/Topo IB signature motif; other site
1266844001409	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266844001410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844001411	active site
1266844001412	phosphorylation site [posttranslational modification]
1266844001413	intermolecular recognition site; other site
1266844001414	dimerization interface [polypeptide binding]; other site
1266844001415	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266844001416	DNA binding site [nucleotide binding]
1266844001417	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
1266844001418	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1266844001419	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
1266844001420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844001421	S-adenosylmethionine binding site [chemical binding]; other site
1266844001422	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1266844001423	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1266844001424	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1266844001425	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1266844001426	active site
1266844001427	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1266844001428	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
1266844001429	peptide binding site [polypeptide binding]; other site
1266844001430	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1266844001431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844001432	dimer interface [polypeptide binding]; other site
1266844001433	conserved gate region; other site
1266844001434	ABC-ATPase subunit interface; other site
1266844001435	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1266844001436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844001437	dimer interface [polypeptide binding]; other site
1266844001438	conserved gate region; other site
1266844001439	putative PBP binding loops; other site
1266844001440	ABC-ATPase subunit interface; other site
1266844001441	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1266844001442	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1266844001443	Walker A/P-loop; other site
1266844001444	ATP binding site [chemical binding]; other site
1266844001445	Q-loop/lid; other site
1266844001446	ABC transporter signature motif; other site
1266844001447	Walker B; other site
1266844001448	D-loop; other site
1266844001449	H-loop/switch region; other site
1266844001450	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1266844001451	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1266844001452	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1266844001453	Walker A/P-loop; other site
1266844001454	ATP binding site [chemical binding]; other site
1266844001455	Q-loop/lid; other site
1266844001456	ABC transporter signature motif; other site
1266844001457	Walker B; other site
1266844001458	D-loop; other site
1266844001459	H-loop/switch region; other site
1266844001460	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1266844001461	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1266844001462	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1266844001463	FMN binding site [chemical binding]; other site
1266844001464	substrate binding site [chemical binding]; other site
1266844001465	putative catalytic residue [active]
1266844001466	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1266844001467	active site
1266844001468	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1266844001469	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
1266844001470	CAS motifs; other site
1266844001471	active site
1266844001472	Purine nucleoside permease (NUP); Region: NUP; pfam06516
1266844001473	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1266844001474	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1266844001475	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1266844001476	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1266844001477	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1266844001478	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844001479	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
1266844001480	Tannase and feruloyl esterase; Region: Tannase; pfam07519
1266844001481	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1266844001482	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844001483	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1266844001484	putative substrate translocation pore; other site
1266844001485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844001486	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1266844001487	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1266844001488	FAD binding pocket [chemical binding]; other site
1266844001489	FAD binding motif [chemical binding]; other site
1266844001490	phosphate binding motif [ion binding]; other site
1266844001491	NAD binding pocket [chemical binding]; other site
1266844001492	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1266844001493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844001494	S-adenosylmethionine binding site [chemical binding]; other site
1266844001495	Predicted transcriptional regulators [Transcription]; Region: COG1695
1266844001496	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1266844001497	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844001498	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844001499	multidrug resistance protein MdtN; Provisional; Region: PRK10476
1266844001500	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1266844001501	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844001502	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1266844001503	Outer membrane efflux protein; Region: OEP; pfam02321
1266844001504	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1266844001505	B12 binding site [chemical binding]; other site
1266844001506	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1266844001507	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1266844001508	FeS/SAM binding site; other site
1266844001509	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
1266844001510	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1266844001511	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1266844001512	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844001513	N-terminal plug; other site
1266844001514	ligand-binding site [chemical binding]; other site
1266844001515	Conserved TM helix; Region: TM_helix; pfam05552
1266844001516	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1266844001517	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1266844001518	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1266844001519	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1266844001520	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1266844001521	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1266844001522	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1266844001523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844001524	Walker A/P-loop; other site
1266844001525	ATP binding site [chemical binding]; other site
1266844001526	Q-loop/lid; other site
1266844001527	ABC transporter signature motif; other site
1266844001528	Walker B; other site
1266844001529	D-loop; other site
1266844001530	H-loop/switch region; other site
1266844001531	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
1266844001532	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266844001533	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844001534	Walker A/P-loop; other site
1266844001535	ATP binding site [chemical binding]; other site
1266844001536	Q-loop/lid; other site
1266844001537	ABC transporter signature motif; other site
1266844001538	Walker B; other site
1266844001539	D-loop; other site
1266844001540	H-loop/switch region; other site
1266844001541	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
1266844001542	catecholate siderophore receptor Fiu; Provisional; Region: PRK09840
1266844001543	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844001544	N-terminal plug; other site
1266844001545	ligand-binding site [chemical binding]; other site
1266844001546	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1266844001547	Sel1-like repeats; Region: SEL1; smart00671
1266844001548	Sel1-like repeats; Region: SEL1; smart00671
1266844001549	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1266844001550	active site
1266844001551	homotetramer interface [polypeptide binding]; other site
1266844001552	homodimer interface [polypeptide binding]; other site
1266844001553	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
1266844001554	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844001555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844001556	homodimer interface [polypeptide binding]; other site
1266844001557	catalytic residue [active]
1266844001558	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
1266844001559	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1266844001560	TrkA-C domain; Region: TrkA_C; pfam02080
1266844001561	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
1266844001562	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1266844001563	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1266844001564	Helix-turn-helix domain; Region: HTH_38; pfam13936
1266844001565	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1266844001566	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1266844001567	Transposase; Region: HTH_Tnp_1; pfam01527
1266844001568	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1266844001569	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1266844001570	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1266844001571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1266844001572	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1266844001573	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1266844001574	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1266844001575	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1266844001576	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1266844001577	active site
1266844001578	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1266844001579	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1266844001580	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1266844001581	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1266844001582	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266844001583	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844001584	Walker A/P-loop; other site
1266844001585	ATP binding site [chemical binding]; other site
1266844001586	Q-loop/lid; other site
1266844001587	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266844001588	ABC transporter signature motif; other site
1266844001589	Walker B; other site
1266844001590	ABC transporter; Region: ABC_tran_2; pfam12848
1266844001591	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266844001592	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844001593	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844001594	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1266844001595	dimerization interface [polypeptide binding]; other site
1266844001596	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
1266844001597	Hint domain; Region: Hint_2; pfam13403
1266844001598	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844001599	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844001600	N-terminal plug; other site
1266844001601	ligand-binding site [chemical binding]; other site
1266844001602	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1266844001603	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1266844001604	putative NAD(P) binding site [chemical binding]; other site
1266844001605	putative substrate binding site [chemical binding]; other site
1266844001606	catalytic Zn binding site [ion binding]; other site
1266844001607	structural Zn binding site [ion binding]; other site
1266844001608	dimer interface [polypeptide binding]; other site
1266844001609	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
1266844001610	SnoaL-like domain; Region: SnoaL_2; pfam12680
1266844001611	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
1266844001612	dimerization interface [polypeptide binding]; other site
1266844001613	metal binding site [ion binding]; metal-binding site
1266844001614	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1266844001615	catalytic core [active]
1266844001616	MgtC family; Region: MgtC; pfam02308
1266844001617	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1266844001618	putative CoA-transferase; Provisional; Region: PRK11430
1266844001619	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1266844001620	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
1266844001621	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1266844001622	PYR/PP interface [polypeptide binding]; other site
1266844001623	dimer interface [polypeptide binding]; other site
1266844001624	TPP binding site [chemical binding]; other site
1266844001625	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1266844001626	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
1266844001627	TPP-binding site; other site
1266844001628	dimer interface [polypeptide binding]; other site
1266844001629	formyl-coenzyme A transferase; Provisional; Region: PRK05398
1266844001630	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1266844001631	oxidoreductase; Provisional; Region: PRK12742
1266844001632	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844001633	NAD(P) binding site [chemical binding]; other site
1266844001634	active site
1266844001635	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844001636	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844001637	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1266844001638	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844001639	NAD(P) binding site [chemical binding]; other site
1266844001640	active site
1266844001641	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1266844001642	putative hydrophobic ligand binding site [chemical binding]; other site
1266844001643	protein interface [polypeptide binding]; other site
1266844001644	gate; other site
1266844001645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844001646	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1266844001647	putative substrate translocation pore; other site
1266844001648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844001649	phosphoglucomutase; Validated; Region: PRK07564
1266844001650	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1266844001651	active site
1266844001652	substrate binding site [chemical binding]; other site
1266844001653	metal binding site [ion binding]; metal-binding site
1266844001654	maltose O-acetyltransferase; Provisional; Region: PRK10092
1266844001655	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1266844001656	active site
1266844001657	substrate binding site [chemical binding]; other site
1266844001658	trimer interface [polypeptide binding]; other site
1266844001659	CoA binding site [chemical binding]; other site
1266844001660	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1266844001661	Hint domain; Region: Hint_2; pfam13403
1266844001662	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844001663	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844001664	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1266844001665	dimerization interface [polypeptide binding]; other site
1266844001666	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1266844001667	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844001668	N-terminal plug; other site
1266844001669	ligand-binding site [chemical binding]; other site
1266844001670	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1266844001671	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1266844001672	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1266844001673	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1266844001674	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844001675	N-terminal plug; other site
1266844001676	ligand-binding site [chemical binding]; other site
1266844001677	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1266844001678	FecR protein; Region: FecR; pfam04773
1266844001679	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
1266844001680	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1266844001681	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1266844001682	DNA binding residues [nucleotide binding]
1266844001683	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1266844001684	sensor protein QseC; Provisional; Region: PRK10337
1266844001685	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266844001686	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266844001687	dimer interface [polypeptide binding]; other site
1266844001688	phosphorylation site [posttranslational modification]
1266844001689	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266844001690	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844001691	active site
1266844001692	phosphorylation site [posttranslational modification]
1266844001693	intermolecular recognition site; other site
1266844001694	dimerization interface [polypeptide binding]; other site
1266844001695	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266844001696	DNA binding site [nucleotide binding]
1266844001697	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1266844001698	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1266844001699	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1266844001700	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844001701	Outer membrane efflux protein; Region: OEP; pfam02321
1266844001702	Outer membrane efflux protein; Region: OEP; pfam02321
1266844001703	acyl-CoA synthetase; Validated; Region: PRK09192
1266844001704	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1266844001705	acyl-activating enzyme (AAE) consensus motif; other site
1266844001706	active site
1266844001707	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1266844001708	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1266844001709	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1266844001710	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1266844001711	catalytic residue [active]
1266844001712	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1266844001713	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1266844001714	active site
1266844001715	metal binding site [ion binding]; metal-binding site
1266844001716	Predicted permeases [General function prediction only]; Region: COG0795
1266844001717	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1266844001718	Predicted permeases [General function prediction only]; Region: COG0795
1266844001719	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1266844001720	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1266844001721	active site
1266844001722	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
1266844001723	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1266844001724	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266844001725	motif II; other site
1266844001726	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
1266844001727	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1266844001728	Substrate binding site; other site
1266844001729	Mg++ binding site; other site
1266844001730	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1266844001731	active site
1266844001732	substrate binding site [chemical binding]; other site
1266844001733	CoA binding site [chemical binding]; other site
1266844001734	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1266844001735	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1266844001736	glutaminase active site [active]
1266844001737	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1266844001738	dimer interface [polypeptide binding]; other site
1266844001739	active site
1266844001740	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1266844001741	dimer interface [polypeptide binding]; other site
1266844001742	active site
1266844001743	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
1266844001744	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1266844001745	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1266844001746	Bacterial transcriptional regulator; Region: IclR; pfam01614
1266844001747	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1266844001748	catalytic residues [active]
1266844001749	dimer interface [polypeptide binding]; other site
1266844001750	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1266844001751	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1266844001752	Walker A/P-loop; other site
1266844001753	ATP binding site [chemical binding]; other site
1266844001754	Q-loop/lid; other site
1266844001755	ABC transporter signature motif; other site
1266844001756	Walker B; other site
1266844001757	D-loop; other site
1266844001758	H-loop/switch region; other site
1266844001759	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1266844001760	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1266844001761	FtsX-like permease family; Region: FtsX; pfam02687
1266844001762	prolyl-tRNA synthetase; Provisional; Region: PRK12325
1266844001763	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1266844001764	dimer interface [polypeptide binding]; other site
1266844001765	motif 1; other site
1266844001766	active site
1266844001767	motif 2; other site
1266844001768	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1266844001769	active site
1266844001770	motif 3; other site
1266844001771	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1266844001772	anticodon binding site; other site
1266844001773	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1266844001774	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1266844001775	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1266844001776	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1266844001777	nucleotide binding site [chemical binding]; other site
1266844001778	Type III pantothenate kinase; Region: Pan_kinase; cl17198
1266844001779	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1266844001780	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1266844001781	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1266844001782	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1266844001783	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1266844001784	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1266844001785	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1266844001786	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1266844001787	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1266844001788	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1266844001789	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1266844001790	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1266844001791	4Fe-4S binding domain; Region: Fer4; cl02805
1266844001792	4Fe-4S binding domain; Region: Fer4; pfam00037
1266844001793	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1266844001794	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1266844001795	NADH dehydrogenase subunit G; Validated; Region: PRK09130
1266844001796	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1266844001797	catalytic loop [active]
1266844001798	iron binding site [ion binding]; other site
1266844001799	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1266844001800	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
1266844001801	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
1266844001802	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
1266844001803	SLBB domain; Region: SLBB; pfam10531
1266844001804	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1266844001805	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1266844001806	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1266844001807	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
1266844001808	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1266844001809	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1266844001810	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
1266844001811	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1266844001812	IHF dimer interface [polypeptide binding]; other site
1266844001813	IHF - DNA interface [nucleotide binding]; other site
1266844001814	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1266844001815	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1266844001816	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844001817	Walker A motif; other site
1266844001818	ATP binding site [chemical binding]; other site
1266844001819	Walker B motif; other site
1266844001820	arginine finger; other site
1266844001821	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1266844001822	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1266844001823	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1266844001824	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844001825	Walker A motif; other site
1266844001826	ATP binding site [chemical binding]; other site
1266844001827	Walker B motif; other site
1266844001828	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1266844001829	Clp protease; Region: CLP_protease; pfam00574
1266844001830	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1266844001831	oligomer interface [polypeptide binding]; other site
1266844001832	active site residues [active]
1266844001833	trigger factor; Provisional; Region: tig; PRK01490
1266844001834	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1266844001835	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1266844001836	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1266844001837	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1266844001838	putative substrate binding site [chemical binding]; other site
1266844001839	putative ATP binding site [chemical binding]; other site
1266844001840	Predicted integral membrane protein [Function unknown]; Region: COG5615
1266844001841	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1266844001842	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1266844001843	ATP binding site [chemical binding]; other site
1266844001844	Mg++ binding site [ion binding]; other site
1266844001845	motif III; other site
1266844001846	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844001847	nucleotide binding region [chemical binding]; other site
1266844001848	ATP-binding site [chemical binding]; other site
1266844001849	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1266844001850	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
1266844001851	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
1266844001852	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1266844001853	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1266844001854	trimerization site [polypeptide binding]; other site
1266844001855	active site
1266844001856	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1266844001857	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1266844001858	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1266844001859	catalytic residue [active]
1266844001860	FeS assembly protein SufD; Region: sufD; TIGR01981
1266844001861	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1266844001862	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1266844001863	FeS assembly ATPase SufC; Region: sufC; TIGR01978
1266844001864	Walker A/P-loop; other site
1266844001865	ATP binding site [chemical binding]; other site
1266844001866	Q-loop/lid; other site
1266844001867	ABC transporter signature motif; other site
1266844001868	Walker B; other site
1266844001869	D-loop; other site
1266844001870	H-loop/switch region; other site
1266844001871	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1266844001872	putative ABC transporter; Region: ycf24; CHL00085
1266844001873	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
1266844001874	Transcriptional regulator; Region: Rrf2; pfam02082
1266844001875	Transcriptional regulator; Region: Rrf2; cl17282
1266844001876	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1266844001877	Peroxin-3; Region: Peroxin-3; pfam04882
1266844001878	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
1266844001879	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1266844001880	elongation factor G; Reviewed; Region: PRK12739
1266844001881	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1266844001882	G1 box; other site
1266844001883	putative GEF interaction site [polypeptide binding]; other site
1266844001884	GTP/Mg2+ binding site [chemical binding]; other site
1266844001885	Switch I region; other site
1266844001886	G2 box; other site
1266844001887	G3 box; other site
1266844001888	Switch II region; other site
1266844001889	G4 box; other site
1266844001890	G5 box; other site
1266844001891	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1266844001892	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1266844001893	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1266844001894	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1266844001895	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266844001896	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1266844001897	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
1266844001898	Walker A/P-loop; other site
1266844001899	ATP binding site [chemical binding]; other site
1266844001900	Q-loop/lid; other site
1266844001901	ABC transporter signature motif; other site
1266844001902	Walker B; other site
1266844001903	D-loop; other site
1266844001904	H-loop/switch region; other site
1266844001905	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1266844001906	nudix motif; other site
1266844001907	PII uridylyl-transferase; Provisional; Region: PRK05092
1266844001908	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1266844001909	metal binding triad; other site
1266844001910	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1266844001911	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1266844001912	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1266844001913	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1266844001914	MutS domain I; Region: MutS_I; pfam01624
1266844001915	MutS domain II; Region: MutS_II; pfam05188
1266844001916	MutS domain III; Region: MutS_III; pfam05192
1266844001917	MutS domain V; Region: MutS_V; pfam00488
1266844001918	Walker A/P-loop; other site
1266844001919	ATP binding site [chemical binding]; other site
1266844001920	Q-loop/lid; other site
1266844001921	ABC transporter signature motif; other site
1266844001922	Walker B; other site
1266844001923	D-loop; other site
1266844001924	H-loop/switch region; other site
1266844001925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1266844001926	binding surface
1266844001927	TPR motif; other site
1266844001928	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1266844001929	binding surface
1266844001930	TPR motif; other site
1266844001931	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1266844001932	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1266844001933	active site
1266844001934	Zn binding site [ion binding]; other site
1266844001935	Major royal jelly protein; Region: MRJP; pfam03022
1266844001936	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1266844001937	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1266844001938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844001939	catalytic residue [active]
1266844001940	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1266844001941	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1266844001942	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1266844001943	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1266844001944	Tim44-like domain; Region: Tim44; pfam04280
1266844001945	PalH/RIM21; Region: PalH; pfam08733
1266844001946	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1266844001947	UbiA prenyltransferase family; Region: UbiA; pfam01040
1266844001948	cytochrome c oxidase subunit I; Provisional; Region: COX1; MTH00182
1266844001949	cytochrome c oxidase subunit I; Provisional; Region: COX1; MTH00182
1266844001950	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844001951	S-adenosylmethionine binding site [chemical binding]; other site
1266844001952	glutathione synthetase; Provisional; Region: PRK05246
1266844001953	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1266844001954	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1266844001955	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1266844001956	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1266844001957	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1266844001958	Ligand binding site; other site
1266844001959	Putative Catalytic site; other site
1266844001960	DXD motif; other site
1266844001961	Predicted membrane protein [Function unknown]; Region: COG2246
1266844001962	GtrA-like protein; Region: GtrA; pfam04138
1266844001963	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1266844001964	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1266844001965	putative Zn2+ binding site [ion binding]; other site
1266844001966	AsnC family; Region: AsnC_trans_reg; pfam01037
1266844001967	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1266844001968	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1266844001969	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1266844001970	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844001971	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844001972	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1266844001973	putative effector binding pocket; other site
1266844001974	dimerization interface [polypeptide binding]; other site
1266844001975	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
1266844001976	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1266844001977	IHF - DNA interface [nucleotide binding]; other site
1266844001978	IHF dimer interface [polypeptide binding]; other site
1266844001979	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
1266844001980	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1266844001981	Fe-S cluster binding site [ion binding]; other site
1266844001982	active site
1266844001983	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1266844001984	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1266844001985	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1266844001986	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
1266844001987	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1266844001988	DNA binding residues [nucleotide binding]
1266844001989	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1266844001990	IHF - DNA interface [nucleotide binding]; other site
1266844001991	IHF dimer interface [polypeptide binding]; other site
1266844001992	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1266844001993	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1266844001994	dimer interface [polypeptide binding]; other site
1266844001995	active site
1266844001996	CoA binding pocket [chemical binding]; other site
1266844001997	putative phosphate acyltransferase; Provisional; Region: PRK05331
1266844001998	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1266844001999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1266844002000	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1266844002001	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1266844002002	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1266844002003	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1266844002004	dimerization interface [polypeptide binding]; other site
1266844002005	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266844002006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844002007	active site
1266844002008	phosphorylation site [posttranslational modification]
1266844002009	intermolecular recognition site; other site
1266844002010	dimerization interface [polypeptide binding]; other site
1266844002011	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266844002012	DNA binding site [nucleotide binding]
1266844002013	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1266844002014	MarR family; Region: MarR_2; pfam12802
1266844002015	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
1266844002016	COQ9; Region: COQ9; pfam08511
1266844002017	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1266844002018	active site
1266844002019	catalytic residues [active]
1266844002020	metal binding site [ion binding]; metal-binding site
1266844002021	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1266844002022	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1266844002023	tartrate dehydrogenase; Region: TTC; TIGR02089
1266844002024	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1266844002025	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1266844002026	substrate binding site [chemical binding]; other site
1266844002027	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1266844002028	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1266844002029	substrate binding site [chemical binding]; other site
1266844002030	ligand binding site [chemical binding]; other site
1266844002031	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1266844002032	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1266844002033	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1266844002034	RimM N-terminal domain; Region: RimM; pfam01782
1266844002035	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1266844002036	signal recognition particle protein; Provisional; Region: PRK10867
1266844002037	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1266844002038	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1266844002039	P loop; other site
1266844002040	GTP binding site [chemical binding]; other site
1266844002041	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1266844002042	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1266844002043	dimer interface [polypeptide binding]; other site
1266844002044	ATP12 chaperone protein; Region: ATP12; pfam07542
1266844002045	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1266844002046	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1266844002047	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1266844002048	RNA binding surface [nucleotide binding]; other site
1266844002049	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1266844002050	active site
1266844002051	recombination factor protein RarA; Reviewed; Region: PRK13342
1266844002052	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844002053	Walker A motif; other site
1266844002054	ATP binding site [chemical binding]; other site
1266844002055	Walker B motif; other site
1266844002056	arginine finger; other site
1266844002057	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1266844002058	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1266844002059	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
1266844002060	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1266844002061	UbiA prenyltransferase family; Region: UbiA; pfam01040
1266844002062	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1266844002063	RNA methyltransferase, RsmE family; Region: TIGR00046
1266844002064	glutamate--cysteine ligase; Region: PLN02611
1266844002065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844002066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844002067	GTP-binding protein Der; Reviewed; Region: PRK00093
1266844002068	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1266844002069	G1 box; other site
1266844002070	GTP/Mg2+ binding site [chemical binding]; other site
1266844002071	Switch I region; other site
1266844002072	G2 box; other site
1266844002073	Switch II region; other site
1266844002074	G3 box; other site
1266844002075	G4 box; other site
1266844002076	G5 box; other site
1266844002077	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1266844002078	G1 box; other site
1266844002079	GTP/Mg2+ binding site [chemical binding]; other site
1266844002080	Switch I region; other site
1266844002081	G2 box; other site
1266844002082	G3 box; other site
1266844002083	Switch II region; other site
1266844002084	G4 box; other site
1266844002085	G5 box; other site
1266844002086	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1266844002087	Trp docking motif [polypeptide binding]; other site
1266844002088	active site
1266844002089	PQQ-like domain; Region: PQQ_2; pfam13360
1266844002090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
1266844002091	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
1266844002092	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1266844002093	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1266844002094	putative active site [active]
1266844002095	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1266844002096	putative ADP-binding pocket [chemical binding]; other site
1266844002097	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844002098	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1266844002099	active site
1266844002100	dimer interface [polypeptide binding]; other site
1266844002101	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
1266844002102	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1266844002103	Ligand Binding Site [chemical binding]; other site
1266844002104	Molecular Tunnel; other site
1266844002105	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1266844002106	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1266844002107	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1266844002108	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1266844002109	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1266844002110	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1266844002111	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1266844002112	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1266844002113	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1266844002114	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1266844002115	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1266844002116	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1266844002117	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1266844002118	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1266844002119	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1266844002120	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1266844002121	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1266844002122	Clp amino terminal domain; Region: Clp_N; pfam02861
1266844002123	Clp amino terminal domain; Region: Clp_N; pfam02861
1266844002124	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844002125	Walker A motif; other site
1266844002126	ATP binding site [chemical binding]; other site
1266844002127	Walker B motif; other site
1266844002128	arginine finger; other site
1266844002129	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844002130	Walker A motif; other site
1266844002131	ATP binding site [chemical binding]; other site
1266844002132	Walker B motif; other site
1266844002133	arginine finger; other site
1266844002134	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1266844002135	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1266844002136	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1266844002137	nudix motif; other site
1266844002138	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1266844002139	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1266844002140	HflX GTPase family; Region: HflX; cd01878
1266844002141	G1 box; other site
1266844002142	GTP/Mg2+ binding site [chemical binding]; other site
1266844002143	Switch I region; other site
1266844002144	G2 box; other site
1266844002145	G3 box; other site
1266844002146	Switch II region; other site
1266844002147	G4 box; other site
1266844002148	G5 box; other site
1266844002149	bacterial Hfq-like; Region: Hfq; cd01716
1266844002150	hexamer interface [polypeptide binding]; other site
1266844002151	Sm1 motif; other site
1266844002152	RNA binding site [nucleotide binding]; other site
1266844002153	Sm2 motif; other site
1266844002154	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1266844002155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844002156	active site
1266844002157	phosphorylation site [posttranslational modification]
1266844002158	intermolecular recognition site; other site
1266844002159	dimerization interface [polypeptide binding]; other site
1266844002160	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844002161	Walker A motif; other site
1266844002162	ATP binding site [chemical binding]; other site
1266844002163	Walker B motif; other site
1266844002164	arginine finger; other site
1266844002165	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1266844002166	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
1266844002167	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1266844002168	dimerization interface [polypeptide binding]; other site
1266844002169	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266844002170	dimer interface [polypeptide binding]; other site
1266844002171	phosphorylation site [posttranslational modification]
1266844002172	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844002173	ATP binding site [chemical binding]; other site
1266844002174	Mg2+ binding site [ion binding]; other site
1266844002175	G-X-G motif; other site
1266844002176	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1266844002177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844002178	active site
1266844002179	phosphorylation site [posttranslational modification]
1266844002180	intermolecular recognition site; other site
1266844002181	dimerization interface [polypeptide binding]; other site
1266844002182	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844002183	Walker A motif; other site
1266844002184	ATP binding site [chemical binding]; other site
1266844002185	Walker B motif; other site
1266844002186	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1266844002187	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1266844002188	PAS domain; Region: PAS; smart00091
1266844002189	putative active site [active]
1266844002190	heme pocket [chemical binding]; other site
1266844002191	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266844002192	dimer interface [polypeptide binding]; other site
1266844002193	phosphorylation site [posttranslational modification]
1266844002194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844002195	ATP binding site [chemical binding]; other site
1266844002196	Mg2+ binding site [ion binding]; other site
1266844002197	G-X-G motif; other site
1266844002198	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1266844002199	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1266844002200	FMN binding site [chemical binding]; other site
1266844002201	active site
1266844002202	catalytic residues [active]
1266844002203	substrate binding site [chemical binding]; other site
1266844002204	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
1266844002205	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1266844002206	substrate binding site; other site
1266844002207	dimer interface; other site
1266844002208	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1266844002209	homotrimer interaction site [polypeptide binding]; other site
1266844002210	zinc binding site [ion binding]; other site
1266844002211	CDP-binding sites; other site
1266844002212	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1266844002213	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1266844002214	Ligand binding site; other site
1266844002215	Putative Catalytic site; other site
1266844002216	DXD motif; other site
1266844002217	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1266844002218	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1266844002219	active site
1266844002220	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1266844002221	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1266844002222	UDP-galactopyranose mutase; Region: GLF; pfam03275
1266844002223	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1266844002224	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1266844002225	active site
1266844002226	integrase; Provisional; Region: PRK09692
1266844002227	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266844002228	active site
1266844002229	DNA binding site [nucleotide binding]
1266844002230	Int/Topo IB signature motif; other site
1266844002231	D5 N terminal like; Region: D5_N; pfam08706
1266844002232	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
1266844002233	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
1266844002234	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1266844002235	active site
1266844002236	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844002237	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1266844002238	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1266844002239	active site
1266844002240	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1266844002241	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1266844002242	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1266844002243	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1266844002244	Transposase domain (DUF772); Region: DUF772; pfam05598
1266844002245	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
1266844002246	Acid Phosphatase; Region: Acid_PPase; cl17256
1266844002247	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1266844002248	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
1266844002249	Transposase domain (DUF772); Region: DUF772; pfam05598
1266844002250	Transposase domain (DUF772); Region: DUF772; pfam05598
1266844002251	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1266844002252	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1266844002253	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1266844002254	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
1266844002255	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1266844002256	trimer interface [polypeptide binding]; other site
1266844002257	active site
1266844002258	substrate binding site [chemical binding]; other site
1266844002259	CoA binding site [chemical binding]; other site
1266844002260	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1266844002261	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1266844002262	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1266844002263	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1266844002264	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1266844002265	active site
1266844002266	catalytic residues [active]
1266844002267	DNA binding site [nucleotide binding]
1266844002268	Int/Topo IB signature motif; other site
1266844002269	elongation factor P; Validated; Region: PRK00529
1266844002270	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1266844002271	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1266844002272	RNA binding site [nucleotide binding]; other site
1266844002273	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1266844002274	RNA binding site [nucleotide binding]; other site
1266844002275	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1266844002276	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1266844002277	active site
1266844002278	dimerization interface [polypeptide binding]; other site
1266844002279	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1266844002280	ATP binding site [chemical binding]; other site
1266844002281	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1266844002282	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1266844002283	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1266844002284	DNA-binding site [nucleotide binding]; DNA binding site
1266844002285	RNA-binding motif; other site
1266844002286	Dienelactone hydrolase family; Region: DLH; pfam01738
1266844002287	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1266844002288	oligomerisation interface [polypeptide binding]; other site
1266844002289	mobile loop; other site
1266844002290	roof hairpin; other site
1266844002291	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1266844002292	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1266844002293	ring oligomerisation interface [polypeptide binding]; other site
1266844002294	ATP/Mg binding site [chemical binding]; other site
1266844002295	stacking interactions; other site
1266844002296	hinge regions; other site
1266844002297	FkbH-like domain; Region: FkbH; TIGR01686
1266844002298	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266844002299	active site
1266844002300	motif I; other site
1266844002301	motif II; other site
1266844002302	FkbH-like domain; Region: FkbH; TIGR01686
1266844002303	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266844002304	active site
1266844002305	motif I; other site
1266844002306	motif II; other site
1266844002307	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1266844002308	active site
1266844002309	catalytic triad [active]
1266844002310	oxyanion hole [active]
1266844002311	Protein of unknown function (DUF563); Region: DUF563; pfam04577
1266844002312	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844002313	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844002314	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
1266844002315	Right handed beta helix region; Region: Beta_helix; pfam13229
1266844002316	Hint domain; Region: Hint_2; pfam13403
1266844002317	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844002318	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1266844002319	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844002320	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844002321	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844002322	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1266844002323	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1266844002324	Aspartyl protease; Region: Asp_protease_2; pfam13650
1266844002325	inhibitor binding site; inhibition site
1266844002326	catalytic motif [active]
1266844002327	Catalytic residue [active]
1266844002328	Active site flap [active]
1266844002329	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
1266844002330	inhibitor binding site; inhibition site
1266844002331	catalytic motif [active]
1266844002332	Catalytic residue [active]
1266844002333	Active site flap [active]
1266844002334	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1266844002335	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1266844002336	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1266844002337	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266844002338	active site
1266844002339	DNA binding site [nucleotide binding]
1266844002340	Int/Topo IB signature motif; other site
1266844002341	primosome assembly protein PriA; Validated; Region: PRK05580
1266844002342	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266844002343	ATP binding site [chemical binding]; other site
1266844002344	putative Mg++ binding site [ion binding]; other site
1266844002345	Preprotein translocase subunit; Region: YajC; pfam02699
1266844002346	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1266844002347	Protein of unknown function (DUF815); Region: DUF815; pfam05673
1266844002348	Probable transposase; Region: OrfB_IS605; pfam01385
1266844002349	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1266844002350	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1266844002351	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1266844002352	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1266844002353	Probable transposase; Region: OrfB_IS605; pfam01385
1266844002354	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1266844002355	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1266844002356	[2Fe-2S] cluster binding site [ion binding]; other site
1266844002357	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1266844002358	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1266844002359	Coenzyme A binding pocket [chemical binding]; other site
1266844002360	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1266844002361	active site
1266844002362	8-oxo-dGMP binding site [chemical binding]; other site
1266844002363	nudix motif; other site
1266844002364	metal binding site [ion binding]; metal-binding site
1266844002365	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1266844002366	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1266844002367	Substrate binding site; other site
1266844002368	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1266844002369	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
1266844002370	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1266844002371	homodimer interface [polypeptide binding]; other site
1266844002372	substrate-cofactor binding pocket; other site
1266844002373	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844002374	catalytic residue [active]
1266844002375	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
1266844002376	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1266844002377	GTP cyclohydrolase I; Provisional; Region: PLN03044
1266844002378	active site
1266844002379	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1266844002380	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
1266844002381	conserved cys residue [active]
1266844002382	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1266844002383	MPT binding site; other site
1266844002384	trimer interface [polypeptide binding]; other site
1266844002385	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1266844002386	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1266844002387	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1266844002388	active site
1266844002389	metal binding site [ion binding]; metal-binding site
1266844002390	DNA binding site [nucleotide binding]
1266844002391	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1266844002392	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1266844002393	Probable transposase; Region: OrfB_IS605; pfam01385
1266844002394	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1266844002395	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1266844002396	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
1266844002397	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1266844002398	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1266844002399	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844002400	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
1266844002401	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1266844002402	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
1266844002403	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
1266844002404	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1266844002405	homopentamer interface [polypeptide binding]; other site
1266844002406	active site
1266844002407	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1266844002408	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1266844002409	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1266844002410	dimerization interface [polypeptide binding]; other site
1266844002411	active site
1266844002412	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1266844002413	Lumazine binding domain; Region: Lum_binding; pfam00677
1266844002414	Lumazine binding domain; Region: Lum_binding; pfam00677
1266844002415	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1266844002416	catalytic motif [active]
1266844002417	Zn binding site [ion binding]; other site
1266844002418	RibD C-terminal domain; Region: RibD_C; cl17279
1266844002419	cytochrome b; Provisional; Region: CYTB; MTH00145
1266844002420	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1266844002421	Qi binding site; other site
1266844002422	intrachain domain interface; other site
1266844002423	interchain domain interface [polypeptide binding]; other site
1266844002424	heme bH binding site [chemical binding]; other site
1266844002425	heme bL binding site [chemical binding]; other site
1266844002426	Qo binding site; other site
1266844002427	interchain domain interface [polypeptide binding]; other site
1266844002428	intrachain domain interface; other site
1266844002429	Qi binding site; other site
1266844002430	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
1266844002431	Qo binding site; other site
1266844002432	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
1266844002433	Cytochrome c; Region: Cytochrom_C; cl11414
1266844002434	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1266844002435	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1266844002436	[2Fe-2S] cluster binding site [ion binding]; other site
1266844002437	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1266844002438	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1266844002439	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
1266844002440	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1266844002441	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1266844002442	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1266844002443	Hint domain; Region: Hint_2; pfam13403
1266844002444	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1266844002445	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1266844002446	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1266844002447	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1266844002448	GTP1/OBG; Region: GTP1_OBG; pfam01018
1266844002449	Obg GTPase; Region: Obg; cd01898
1266844002450	G1 box; other site
1266844002451	GTP/Mg2+ binding site [chemical binding]; other site
1266844002452	Switch I region; other site
1266844002453	G2 box; other site
1266844002454	G3 box; other site
1266844002455	Switch II region; other site
1266844002456	G4 box; other site
1266844002457	G5 box; other site
1266844002458	gamma-glutamyl kinase; Provisional; Region: PRK05429
1266844002459	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1266844002460	nucleotide binding site [chemical binding]; other site
1266844002461	homotetrameric interface [polypeptide binding]; other site
1266844002462	putative phosphate binding site [ion binding]; other site
1266844002463	putative allosteric binding site; other site
1266844002464	PUA domain; Region: PUA; pfam01472
1266844002465	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
1266844002466	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1266844002467	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1266844002468	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1266844002469	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1266844002470	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1266844002471	substrate binding pocket [chemical binding]; other site
1266844002472	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1266844002473	cell division protein MraZ; Reviewed; Region: PRK00326
1266844002474	MraZ protein; Region: MraZ; pfam02381
1266844002475	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1266844002476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844002477	S-adenosylmethionine binding site [chemical binding]; other site
1266844002478	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
1266844002479	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1266844002480	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1266844002481	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1266844002482	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1266844002483	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1266844002484	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1266844002485	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1266844002486	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
1266844002487	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1266844002488	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1266844002489	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1266844002490	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1266844002491	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1266844002492	Mg++ binding site [ion binding]; other site
1266844002493	putative catalytic motif [active]
1266844002494	putative substrate binding site [chemical binding]; other site
1266844002495	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
1266844002496	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1266844002497	cell division protein FtsW; Region: ftsW; TIGR02614
1266844002498	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
1266844002499	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1266844002500	active site
1266844002501	homodimer interface [polypeptide binding]; other site
1266844002502	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1266844002503	FAD binding domain; Region: FAD_binding_4; pfam01565
1266844002504	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1266844002505	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1266844002506	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1266844002507	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1266844002508	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1266844002509	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1266844002510	Cell division protein FtsQ; Region: FtsQ; pfam03799
1266844002511	Cell division protein FtsA; Region: FtsA; smart00842
1266844002512	cell division protein FtsA; Region: ftsA; TIGR01174
1266844002513	Cell division protein FtsA; Region: FtsA; pfam14450
1266844002514	cell division protein FtsZ; Validated; Region: PRK09330
1266844002515	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1266844002516	nucleotide binding site [chemical binding]; other site
1266844002517	SulA interaction site; other site
1266844002518	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1266844002519	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1266844002520	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
1266844002521	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1266844002522	binding surface
1266844002523	TPR motif; other site
1266844002524	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1266844002525	Walker A/P-loop; other site
1266844002526	ATP binding site [chemical binding]; other site
1266844002527	Q-loop/lid; other site
1266844002528	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1266844002529	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1266844002530	ABC transporter signature motif; other site
1266844002531	Walker B; other site
1266844002532	D-loop; other site
1266844002533	H-loop/switch region; other site
1266844002534	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1266844002535	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1266844002536	nucleotide binding pocket [chemical binding]; other site
1266844002537	K-X-D-G motif; other site
1266844002538	catalytic site [active]
1266844002539	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1266844002540	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1266844002541	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1266844002542	Dimer interface [polypeptide binding]; other site
1266844002543	BRCT sequence motif; other site
1266844002544	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1266844002545	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1266844002546	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1266844002547	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1266844002548	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1266844002549	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1266844002550	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1266844002551	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1266844002552	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1266844002553	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
1266844002554	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
1266844002555	active site
1266844002556	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
1266844002557	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1266844002558	active site
1266844002559	HIGH motif; other site
1266844002560	nucleotide binding site [chemical binding]; other site
1266844002561	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1266844002562	active site
1266844002563	KMSKS motif; other site
1266844002564	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1266844002565	Isochorismatase family; Region: Isochorismatase; pfam00857
1266844002566	catalytic triad [active]
1266844002567	metal binding site [ion binding]; metal-binding site
1266844002568	conserved cis-peptide bond; other site
1266844002569	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1266844002570	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1266844002571	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1266844002572	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1266844002573	metal-binding site [ion binding]
1266844002574	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1266844002575	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1266844002576	metal-binding site [ion binding]
1266844002577	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1266844002578	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
1266844002579	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1266844002580	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1266844002581	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1266844002582	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
1266844002583	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1266844002584	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1266844002585	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1266844002586	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1266844002587	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1266844002588	putative valine binding site [chemical binding]; other site
1266844002589	dimer interface [polypeptide binding]; other site
1266844002590	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1266844002591	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
1266844002592	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1266844002593	PYR/PP interface [polypeptide binding]; other site
1266844002594	dimer interface [polypeptide binding]; other site
1266844002595	TPP binding site [chemical binding]; other site
1266844002596	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1266844002597	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1266844002598	TPP-binding site [chemical binding]; other site
1266844002599	dimer interface [polypeptide binding]; other site
1266844002600	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1266844002601	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
1266844002602	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1266844002603	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266844002604	motif II; other site
1266844002605	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
1266844002606	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1266844002607	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1266844002608	ATP binding site [chemical binding]; other site
1266844002609	putative Mg++ binding site [ion binding]; other site
1266844002610	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844002611	nucleotide binding region [chemical binding]; other site
1266844002612	ATP-binding site [chemical binding]; other site
1266844002613	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844002614	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1266844002615	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844002616	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1266844002617	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1266844002618	active site
1266844002619	Zn binding site [ion binding]; other site
1266844002620	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1266844002621	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1266844002622	dimer interface [polypeptide binding]; other site
1266844002623	active site
1266844002624	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1266844002625	folate binding site [chemical binding]; other site
1266844002626	amino acid transporter; Region: 2A0306; TIGR00909
1266844002627	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1266844002628	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1266844002629	dimer interface [polypeptide binding]; other site
1266844002630	allosteric magnesium binding site [ion binding]; other site
1266844002631	active site
1266844002632	aspartate-rich active site metal binding site; other site
1266844002633	Schiff base residues; other site
1266844002634	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
1266844002635	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1266844002636	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1266844002637	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1266844002638	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1266844002639	CAP-like domain; other site
1266844002640	active site
1266844002641	primary dimer interface [polypeptide binding]; other site
1266844002642	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1266844002643	Recombination protein O N terminal; Region: RecO_N; pfam11967
1266844002644	Recombination protein O C terminal; Region: RecO_C; pfam02565
1266844002645	elongation factor Ts; Provisional; Region: tsf; PRK09377
1266844002646	UBA/TS-N domain; Region: UBA; pfam00627
1266844002647	Elongation factor TS; Region: EF_TS; pfam00889
1266844002648	Elongation factor TS; Region: EF_TS; pfam00889
1266844002649	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1266844002650	rRNA interaction site [nucleotide binding]; other site
1266844002651	S8 interaction site; other site
1266844002652	putative laminin-1 binding site; other site
1266844002653	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1266844002654	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1266844002655	[2Fe-2S] cluster binding site [ion binding]; other site
1266844002656	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1266844002657	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1266844002658	homodimer interface [polypeptide binding]; other site
1266844002659	substrate-cofactor binding pocket; other site
1266844002660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844002661	catalytic residue [active]
1266844002662	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1266844002663	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1266844002664	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1266844002665	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1266844002666	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1266844002667	putative active site [active]
1266844002668	putative PHP Thumb interface [polypeptide binding]; other site
1266844002669	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1266844002670	generic binding surface II; other site
1266844002671	generic binding surface I; other site
1266844002672	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1266844002673	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1266844002674	active site
1266844002675	ATP-binding site [chemical binding]; other site
1266844002676	pantoate-binding site; other site
1266844002677	HXXH motif; other site
1266844002678	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1266844002679	homotrimer interaction site [polypeptide binding]; other site
1266844002680	putative active site [active]
1266844002681	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1266844002682	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1266844002683	aspartate aminotransferase; Provisional; Region: PRK05764
1266844002684	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844002685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844002686	homodimer interface [polypeptide binding]; other site
1266844002687	catalytic residue [active]
1266844002688	aspartate aminotransferase; Provisional; Region: PRK05764
1266844002689	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844002690	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844002691	homodimer interface [polypeptide binding]; other site
1266844002692	catalytic residue [active]
1266844002693	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1266844002694	active site
1266844002695	HIGH motif; other site
1266844002696	nucleotide binding site [chemical binding]; other site
1266844002697	active site
1266844002698	KMSKS motif; other site
1266844002699	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1266844002700	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1266844002701	active site
1266844002702	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1266844002703	metal-binding site [ion binding]
1266844002704	hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367
1266844002705	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1266844002706	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844002707	FeS/SAM binding site; other site
1266844002708	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1266844002709	active site
1266844002710	multimer interface [polypeptide binding]; other site
1266844002711	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1266844002712	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844002713	Walker A/P-loop; other site
1266844002714	ATP binding site [chemical binding]; other site
1266844002715	Q-loop/lid; other site
1266844002716	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266844002717	ABC transporter; Region: ABC_tran_2; pfam12848
1266844002718	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266844002719	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1266844002720	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1266844002721	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266844002722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844002723	active site
1266844002724	phosphorylation site [posttranslational modification]
1266844002725	intermolecular recognition site; other site
1266844002726	dimerization interface [polypeptide binding]; other site
1266844002727	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266844002728	DNA binding site [nucleotide binding]
1266844002729	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266844002730	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1266844002731	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1266844002732	dimer interface [polypeptide binding]; other site
1266844002733	phosphorylation site [posttranslational modification]
1266844002734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844002735	ATP binding site [chemical binding]; other site
1266844002736	Mg2+ binding site [ion binding]; other site
1266844002737	G-X-G motif; other site
1266844002738	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1266844002739	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1266844002740	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1266844002741	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1266844002742	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1266844002743	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1266844002744	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1266844002745	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1266844002746	active site
1266844002747	dimer interface [polypeptide binding]; other site
1266844002748	motif 1; other site
1266844002749	motif 2; other site
1266844002750	motif 3; other site
1266844002751	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1266844002752	anticodon binding site; other site
1266844002753	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1266844002754	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1266844002755	putative active site [active]
1266844002756	TPR repeat; Region: TPR_11; pfam13414
1266844002757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1266844002758	binding surface
1266844002759	TPR motif; other site
1266844002760	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844002761	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
1266844002762	putative ADP-binding pocket [chemical binding]; other site
1266844002763	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
1266844002764	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1266844002765	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1266844002766	RNA/DNA hybrid binding site [nucleotide binding]; other site
1266844002767	active site
1266844002768	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1266844002769	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
1266844002770	putative active site [active]
1266844002771	putative substrate binding site [chemical binding]; other site
1266844002772	ATP binding site [chemical binding]; other site
1266844002773	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1266844002774	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1266844002775	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1266844002776	ABC1 family; Region: ABC1; cl17513
1266844002777	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1266844002778	active site
1266844002779	substrate binding site [chemical binding]; other site
1266844002780	ATP binding site [chemical binding]; other site
1266844002781	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1266844002782	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
1266844002783	active site
1266844002784	Zn binding site [ion binding]; other site
1266844002785	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1266844002786	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1266844002787	active site
1266844002788	dimer interface [polypeptide binding]; other site
1266844002789	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1266844002790	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1266844002791	active site
1266844002792	FMN binding site [chemical binding]; other site
1266844002793	substrate binding site [chemical binding]; other site
1266844002794	3Fe-4S cluster binding site [ion binding]; other site
1266844002795	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1266844002796	domain interface; other site
1266844002797	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1266844002798	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1266844002799	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
1266844002800	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1266844002801	putative NAD(P) binding site [chemical binding]; other site
1266844002802	active site
1266844002803	EamA-like transporter family; Region: EamA; pfam00892
1266844002804	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1266844002805	EamA-like transporter family; Region: EamA; pfam00892
1266844002806	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1266844002807	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1266844002808	active site
1266844002809	metal binding site [ion binding]; metal-binding site
1266844002810	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1266844002811	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
1266844002812	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1266844002813	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1266844002814	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1266844002815	histidinol dehydrogenase; Region: hisD; TIGR00069
1266844002816	NAD binding site [chemical binding]; other site
1266844002817	dimerization interface [polypeptide binding]; other site
1266844002818	product binding site; other site
1266844002819	substrate binding site [chemical binding]; other site
1266844002820	zinc binding site [ion binding]; other site
1266844002821	catalytic residues [active]
1266844002822	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1266844002823	rRNA binding site [nucleotide binding]; other site
1266844002824	predicted 30S ribosome binding site; other site
1266844002825	Maf-like protein; Region: Maf; pfam02545
1266844002826	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1266844002827	active site
1266844002828	dimer interface [polypeptide binding]; other site
1266844002829	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1266844002830	RNA binding site [nucleotide binding]; other site
1266844002831	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
1266844002832	Domain of unknown function (DUF329); Region: DUF329; pfam03884
1266844002833	Cytochrome c; Region: Cytochrom_C; pfam00034
1266844002834	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
1266844002835	homotetramer interface [polypeptide binding]; other site
1266844002836	short chain dehydrogenase; Validated; Region: PRK07069
1266844002837	NAD binding site [chemical binding]; other site
1266844002838	homodimer interface [polypeptide binding]; other site
1266844002839	active site
1266844002840	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1266844002841	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1266844002842	NAD binding site [chemical binding]; other site
1266844002843	catalytic residues [active]
1266844002844	D-lactate dehydrogenase; Provisional; Region: PRK11183
1266844002845	FAD binding domain; Region: FAD_binding_4; pfam01565
1266844002846	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1266844002847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
1266844002848	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
1266844002849	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1266844002850	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1266844002851	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1266844002852	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1266844002853	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1266844002854	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1266844002855	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
1266844002856	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1266844002857	dimerization interface [polypeptide binding]; other site
1266844002858	active site
1266844002859	quinolinate synthetase; Provisional; Region: PRK09375
1266844002860	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1266844002861	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844002862	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844002863	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1266844002864	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1266844002865	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1266844002866	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1266844002867	NAD(P) binding site [chemical binding]; other site
1266844002868	catalytic residues [active]
1266844002869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844002870	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1266844002871	putative substrate translocation pore; other site
1266844002872	Domain of unknown function (DUF336); Region: DUF336; pfam03928
1266844002873	Predicted flavoprotein [General function prediction only]; Region: COG0431
1266844002874	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1266844002875	Pirin-related protein [General function prediction only]; Region: COG1741
1266844002876	Pirin; Region: Pirin; pfam02678
1266844002877	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1266844002878	LysR family transcriptional regulator; Provisional; Region: PRK14997
1266844002879	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844002880	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1266844002881	putative effector binding pocket; other site
1266844002882	putative dimerization interface [polypeptide binding]; other site
1266844002883	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1266844002884	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1266844002885	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1266844002886	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1266844002887	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1266844002888	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1266844002889	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844002890	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1266844002891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844002892	D-galactonate transporter; Region: 2A0114; TIGR00893
1266844002893	putative substrate translocation pore; other site
1266844002894	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1266844002895	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1266844002896	putative active site [active]
1266844002897	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1266844002898	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1266844002899	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1266844002900	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1266844002901	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844002902	NAD(P) binding site [chemical binding]; other site
1266844002903	active site
1266844002904	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1266844002905	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1266844002906	carboxyltransferase (CT) interaction site; other site
1266844002907	biotinylation site [posttranslational modification]; other site
1266844002908	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1266844002909	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1266844002910	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1266844002911	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1266844002912	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1266844002913	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1266844002914	carboxyltransferase (CT) interaction site; other site
1266844002915	biotinylation site [posttranslational modification]; other site
1266844002916	aspartate aminotransferase; Provisional; Region: PRK05764
1266844002917	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844002918	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844002919	homodimer interface [polypeptide binding]; other site
1266844002920	catalytic residue [active]
1266844002921	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
1266844002922	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844002923	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1266844002924	putative dimerization interface [polypeptide binding]; other site
1266844002925	amidase; Provisional; Region: PRK07056
1266844002926	Amidase; Region: Amidase; cl11426
1266844002927	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844002928	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844002929	short chain dehydrogenase; Provisional; Region: PRK09291
1266844002930	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844002931	NAD(P) binding site [chemical binding]; other site
1266844002932	active site
1266844002933	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
1266844002934	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1266844002935	active site
1266844002936	catalytic site [active]
1266844002937	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1266844002938	catalytic site [active]
1266844002939	active site
1266844002940	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1266844002941	glycogen branching enzyme; Provisional; Region: PRK05402
1266844002942	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1266844002943	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1266844002944	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1266844002945	active site
1266844002946	catalytic site [active]
1266844002947	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1266844002948	glycogen synthase; Provisional; Region: glgA; PRK00654
1266844002949	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1266844002950	ADP-binding pocket [chemical binding]; other site
1266844002951	homodimer interface [polypeptide binding]; other site
1266844002952	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1266844002953	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1266844002954	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1266844002955	active site
1266844002956	catalytic site [active]
1266844002957	short chain dehydrogenase; Provisional; Region: PRK06701
1266844002958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844002959	NAD(P) binding site [chemical binding]; other site
1266844002960	active site
1266844002961	thiamine pyrophosphate protein; Provisional; Region: PRK08273
1266844002962	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1266844002963	PYR/PP interface [polypeptide binding]; other site
1266844002964	dimer interface [polypeptide binding]; other site
1266844002965	tetramer interface [polypeptide binding]; other site
1266844002966	TPP binding site [chemical binding]; other site
1266844002967	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1266844002968	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1266844002969	TPP-binding site [chemical binding]; other site
1266844002970	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1266844002971	hypothetical protein; Provisional; Region: PRK06184
1266844002972	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1266844002973	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1266844002974	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1266844002975	Cu(I) binding site [ion binding]; other site
1266844002976	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844002977	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844002978	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
1266844002979	Hint domain; Region: Hint_2; pfam13403
1266844002980	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1266844002981	nudix motif; other site
1266844002982	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844002983	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1266844002984	dimerization interface [polypeptide binding]; other site
1266844002985	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1266844002986	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1266844002987	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1266844002988	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1266844002989	Zinc-finger domain; Region: zf-CHCC; pfam10276
1266844002990	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
1266844002991	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1266844002992	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1266844002993	DsbD alpha interface [polypeptide binding]; other site
1266844002994	catalytic residues [active]
1266844002995	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1266844002996	seryl-tRNA synthetase; Provisional; Region: PRK05431
1266844002997	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1266844002998	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1266844002999	dimer interface [polypeptide binding]; other site
1266844003000	active site
1266844003001	motif 1; other site
1266844003002	motif 2; other site
1266844003003	motif 3; other site
1266844003004	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1266844003005	sec-independent translocase; Provisional; Region: tatB; PRK00182
1266844003006	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
1266844003007	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1266844003008	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1266844003009	Sporulation related domain; Region: SPOR; pfam05036
1266844003010	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1266844003011	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1266844003012	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1266844003013	active site
1266844003014	HIGH motif; other site
1266844003015	nucleotide binding site [chemical binding]; other site
1266844003016	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1266844003017	KMSK motif region; other site
1266844003018	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1266844003019	tRNA binding surface [nucleotide binding]; other site
1266844003020	anticodon binding site; other site
1266844003021	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
1266844003022	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1266844003023	Zn2+ binding site [ion binding]; other site
1266844003024	Mg2+ binding site [ion binding]; other site
1266844003025	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1266844003026	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1266844003027	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1266844003028	putative catalytic site [active]
1266844003029	putative phosphate binding site [ion binding]; other site
1266844003030	active site
1266844003031	metal binding site A [ion binding]; metal-binding site
1266844003032	DNA binding site [nucleotide binding]
1266844003033	putative AP binding site [nucleotide binding]; other site
1266844003034	putative metal binding site B [ion binding]; other site
1266844003035	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1266844003036	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1266844003037	active site
1266844003038	Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258
1266844003039	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1266844003040	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
1266844003041	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1266844003042	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
1266844003043	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
1266844003044	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
1266844003045	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
1266844003046	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
1266844003047	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
1266844003048	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844003049	FeS/SAM binding site; other site
1266844003050	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1266844003051	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1266844003052	dinuclear metal binding motif [ion binding]; other site
1266844003053	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1266844003054	Clp protease; Region: CLP_protease; pfam00574
1266844003055	oligomer interface [polypeptide binding]; other site
1266844003056	active site residues [active]
1266844003057	aminotransferase; Validated; Region: PRK09148
1266844003058	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844003059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844003060	homodimer interface [polypeptide binding]; other site
1266844003061	catalytic residue [active]
1266844003062	homoserine dehydrogenase; Provisional; Region: PRK06349
1266844003063	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1266844003064	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1266844003065	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1266844003066	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1266844003067	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1266844003068	putative active site [active]
1266844003069	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1266844003070	DHH family; Region: DHH; pfam01368
1266844003071	DHHA1 domain; Region: DHHA1; pfam02272
1266844003072	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1266844003073	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1266844003074	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1266844003075	DNA binding residues [nucleotide binding]
1266844003076	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1266844003077	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1266844003078	RNA binding surface [nucleotide binding]; other site
1266844003079	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1266844003080	active site
1266844003081	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1266844003082	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1266844003083	ABC-ATPase subunit  interface; other site
1266844003084	dimer interface [polypeptide binding]; other site
1266844003085	putative PBP binding regions; other site
1266844003086	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1266844003087	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1266844003088	Walker A/P-loop; other site
1266844003089	ATP binding site [chemical binding]; other site
1266844003090	Q-loop/lid; other site
1266844003091	ABC transporter signature motif; other site
1266844003092	Walker B; other site
1266844003093	D-loop; other site
1266844003094	H-loop/switch region; other site
1266844003095	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1266844003096	hypothetical protein; Validated; Region: PRK00029
1266844003097	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1266844003098	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1266844003099	homodimer interface [polypeptide binding]; other site
1266844003100	substrate-cofactor binding pocket; other site
1266844003101	catalytic residue [active]
1266844003102	DNA polymerase I; Provisional; Region: PRK05755
1266844003103	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1266844003104	active site
1266844003105	metal binding site 1 [ion binding]; metal-binding site
1266844003106	putative 5' ssDNA interaction site; other site
1266844003107	metal binding site 3; metal-binding site
1266844003108	metal binding site 2 [ion binding]; metal-binding site
1266844003109	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1266844003110	putative DNA binding site [nucleotide binding]; other site
1266844003111	putative metal binding site [ion binding]; other site
1266844003112	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1266844003113	active site
1266844003114	catalytic site [active]
1266844003115	substrate binding site [chemical binding]; other site
1266844003116	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1266844003117	active site
1266844003118	DNA binding site [nucleotide binding]
1266844003119	catalytic site [active]
1266844003120	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1266844003121	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1266844003122	Cu(I) binding site [ion binding]; other site
1266844003123	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1266844003124	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1266844003125	putative acyl-acceptor binding pocket; other site
1266844003126	proline/glycine betaine transporter; Provisional; Region: PRK10642
1266844003127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844003128	putative substrate translocation pore; other site
1266844003129	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1266844003130	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1266844003131	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1266844003132	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1266844003133	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
1266844003134	L-asparagine permease; Provisional; Region: PRK15049
1266844003135	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1266844003136	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1266844003137	Trp docking motif [polypeptide binding]; other site
1266844003138	putative active site [active]
1266844003139	Hint domain; Region: Hint_2; pfam13403
1266844003140	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844003141	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844003142	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1266844003143	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
1266844003144	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1266844003145	inhibitor-cofactor binding pocket; inhibition site
1266844003146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844003147	catalytic residue [active]
1266844003148	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1266844003149	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1266844003150	DNA-binding site [nucleotide binding]; DNA binding site
1266844003151	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844003152	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844003153	homodimer interface [polypeptide binding]; other site
1266844003154	catalytic residue [active]
1266844003155	allantoate amidohydrolase; Reviewed; Region: PRK09290
1266844003156	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1266844003157	active site
1266844003158	metal binding site [ion binding]; metal-binding site
1266844003159	dimer interface [polypeptide binding]; other site
1266844003160	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
1266844003161	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
1266844003162	homodimer interface [polypeptide binding]; other site
1266844003163	active site
1266844003164	FMN binding site [chemical binding]; other site
1266844003165	substrate binding site [chemical binding]; other site
1266844003166	4Fe-4S binding domain; Region: Fer4; pfam00037
1266844003167	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1266844003168	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1266844003169	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1266844003170	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844003171	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844003172	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
1266844003173	phenylhydantoinase; Validated; Region: PRK08323
1266844003174	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1266844003175	tetramer interface [polypeptide binding]; other site
1266844003176	active site
1266844003177	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1266844003178	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1266844003179	Na binding site [ion binding]; other site
1266844003180	putative substrate binding site [chemical binding]; other site
1266844003181	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844003182	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1266844003183	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1266844003184	active site
1266844003185	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1266844003186	active site
1266844003187	dimer interface [polypeptide binding]; other site
1266844003188	Preprotein translocase subunit SecB; Region: SecB; pfam02556
1266844003189	SecA binding site; other site
1266844003190	Preprotein binding site; other site
1266844003191	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
1266844003192	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1266844003193	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1266844003194	active site
1266844003195	hydrophilic channel; other site
1266844003196	catalytic residues [active]
1266844003197	active site lid [active]
1266844003198	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1266844003199	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
1266844003200	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1266844003201	Na binding site [ion binding]; other site
1266844003202	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
1266844003203	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
1266844003204	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1266844003205	Beta-lactamase; Region: Beta-lactamase; pfam00144
1266844003206	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1266844003207	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844003208	non-specific DNA binding site [nucleotide binding]; other site
1266844003209	salt bridge; other site
1266844003210	sequence-specific DNA binding site [nucleotide binding]; other site
1266844003211	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1266844003212	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1266844003213	heme-binding site [chemical binding]; other site
1266844003214	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1266844003215	FAD binding pocket [chemical binding]; other site
1266844003216	FAD binding motif [chemical binding]; other site
1266844003217	phosphate binding motif [ion binding]; other site
1266844003218	beta-alpha-beta structure motif; other site
1266844003219	NAD binding pocket [chemical binding]; other site
1266844003220	Heme binding  pocket [chemical binding]; other site
1266844003221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844003222	dimer interface [polypeptide binding]; other site
1266844003223	conserved gate region; other site
1266844003224	putative PBP binding loops; other site
1266844003225	ABC-ATPase subunit interface; other site
1266844003226	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1266844003227	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1266844003228	Walker A/P-loop; other site
1266844003229	ATP binding site [chemical binding]; other site
1266844003230	Q-loop/lid; other site
1266844003231	ABC transporter signature motif; other site
1266844003232	Walker B; other site
1266844003233	D-loop; other site
1266844003234	H-loop/switch region; other site
1266844003235	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1266844003236	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1266844003237	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1266844003238	FAD binding domain; Region: FAD_binding_4; pfam01565
1266844003239	siroheme synthase; Provisional; Region: cysG; PRK10637
1266844003240	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1266844003241	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1266844003242	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1266844003243	active site
1266844003244	SAM binding site [chemical binding]; other site
1266844003245	homodimer interface [polypeptide binding]; other site
1266844003246	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1266844003247	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1266844003248	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1266844003249	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1266844003250	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1266844003251	Amidase; Region: Amidase; cl11426
1266844003252	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1266844003253	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1266844003254	intersubunit interface [polypeptide binding]; other site
1266844003255	active site
1266844003256	Zn2+ binding site [ion binding]; other site
1266844003257	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1266844003258	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1266844003259	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1266844003260	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1266844003261	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1266844003262	FMN-binding pocket [chemical binding]; other site
1266844003263	flavin binding motif; other site
1266844003264	phosphate binding motif [ion binding]; other site
1266844003265	beta-alpha-beta structure motif; other site
1266844003266	NAD binding pocket [chemical binding]; other site
1266844003267	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1266844003268	catalytic loop [active]
1266844003269	iron binding site [ion binding]; other site
1266844003270	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1266844003271	classical (c) SDRs; Region: SDR_c; cd05233
1266844003272	NAD(P) binding site [chemical binding]; other site
1266844003273	active site
1266844003274	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1266844003275	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1266844003276	[2Fe-2S] cluster binding site [ion binding]; other site
1266844003277	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1266844003278	putative alpha subunit interface [polypeptide binding]; other site
1266844003279	putative active site [active]
1266844003280	putative substrate binding site [chemical binding]; other site
1266844003281	Fe binding site [ion binding]; other site
1266844003282	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1266844003283	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1266844003284	active site
1266844003285	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
1266844003286	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1266844003287	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1266844003288	NAD(P) binding site [chemical binding]; other site
1266844003289	catalytic residues [active]
1266844003290	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1266844003291	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
1266844003292	Trp docking motif [polypeptide binding]; other site
1266844003293	cytochrome domain interface [polypeptide binding]; other site
1266844003294	active site
1266844003295	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1266844003296	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844003297	putative substrate translocation pore; other site
1266844003298	SnoaL-like domain; Region: SnoaL_4; pfam13577
1266844003299	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844003300	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844003301	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
1266844003302	putative substrate binding pocket [chemical binding]; other site
1266844003303	dimerization interface [polypeptide binding]; other site
1266844003304	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1266844003305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844003306	dimer interface [polypeptide binding]; other site
1266844003307	conserved gate region; other site
1266844003308	putative PBP binding loops; other site
1266844003309	ABC-ATPase subunit interface; other site
1266844003310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844003311	ABC-ATPase subunit interface; other site
1266844003312	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1266844003313	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1266844003314	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1266844003315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844003316	Walker A/P-loop; other site
1266844003317	ATP binding site [chemical binding]; other site
1266844003318	Q-loop/lid; other site
1266844003319	ABC transporter signature motif; other site
1266844003320	Walker B; other site
1266844003321	D-loop; other site
1266844003322	H-loop/switch region; other site
1266844003323	TOBE domain; Region: TOBE_2; pfam08402
1266844003324	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1266844003325	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
1266844003326	tetrameric interface [polypeptide binding]; other site
1266844003327	NAD binding site [chemical binding]; other site
1266844003328	catalytic residues [active]
1266844003329	substrate binding site [chemical binding]; other site
1266844003330	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
1266844003331	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
1266844003332	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
1266844003333	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1266844003334	Sel1-like repeats; Region: SEL1; smart00671
1266844003335	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844003336	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844003337	N-terminal plug; other site
1266844003338	ligand-binding site [chemical binding]; other site
1266844003339	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1266844003340	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1266844003341	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1266844003342	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1266844003343	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1266844003344	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844003345	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844003346	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1266844003347	dimerization interface [polypeptide binding]; other site
1266844003348	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1266844003349	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1266844003350	[2Fe-2S] cluster binding site [ion binding]; other site
1266844003351	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1266844003352	hydrophobic ligand binding site; other site
1266844003353	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1266844003354	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1266844003355	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1266844003356	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
1266844003357	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
1266844003358	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1266844003359	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1266844003360	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1266844003361	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1266844003362	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1266844003363	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1266844003364	tetramerization interface [polypeptide binding]; other site
1266844003365	NAD(P) binding site [chemical binding]; other site
1266844003366	catalytic residues [active]
1266844003367	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1266844003368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844003369	putative substrate translocation pore; other site
1266844003370	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1266844003371	homotrimer interface [polypeptide binding]; other site
1266844003372	Walker A motif; other site
1266844003373	GTP binding site [chemical binding]; other site
1266844003374	Walker B motif; other site
1266844003375	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1266844003376	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1266844003377	putative dimer interface [polypeptide binding]; other site
1266844003378	active site pocket [active]
1266844003379	putative cataytic base [active]
1266844003380	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1266844003381	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1266844003382	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844003383	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844003384	homodimer interface [polypeptide binding]; other site
1266844003385	catalytic residue [active]
1266844003386	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
1266844003387	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1266844003388	putative FMN binding site [chemical binding]; other site
1266844003389	cobyric acid synthase; Provisional; Region: PRK00784
1266844003390	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1266844003391	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1266844003392	catalytic triad [active]
1266844003393	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
1266844003394	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1266844003395	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1266844003396	homodimer interface [polypeptide binding]; other site
1266844003397	Walker A motif; other site
1266844003398	ATP binding site [chemical binding]; other site
1266844003399	hydroxycobalamin binding site [chemical binding]; other site
1266844003400	Walker B motif; other site
1266844003401	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1266844003402	catalytic core [active]
1266844003403	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1266844003404	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1266844003405	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1266844003406	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
1266844003407	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1266844003408	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1266844003409	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1266844003410	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1266844003411	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1266844003412	dimer interface [polypeptide binding]; other site
1266844003413	[2Fe-2S] cluster binding site [ion binding]; other site
1266844003414	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1266844003415	MarR family; Region: MarR; pfam01047
1266844003416	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1266844003417	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1266844003418	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
1266844003419	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
1266844003420	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1266844003421	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1266844003422	substrate binding site [chemical binding]; other site
1266844003423	oxyanion hole (OAH) forming residues; other site
1266844003424	trimer interface [polypeptide binding]; other site
1266844003425	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1266844003426	Flavin Reductases; Region: FlaRed; cl00801
1266844003427	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1266844003428	dimer interface [polypeptide binding]; other site
1266844003429	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1266844003430	putative PBP binding regions; other site
1266844003431	ABC-ATPase subunit  interface; other site
1266844003432	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1266844003433	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844003434	Walker A/P-loop; other site
1266844003435	ATP binding site [chemical binding]; other site
1266844003436	Q-loop/lid; other site
1266844003437	ABC transporter signature motif; other site
1266844003438	Walker B; other site
1266844003439	D-loop; other site
1266844003440	H-loop/switch region; other site
1266844003441	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1266844003442	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1266844003443	intersubunit interface [polypeptide binding]; other site
1266844003444	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1266844003445	metal binding site 2 [ion binding]; metal-binding site
1266844003446	putative DNA binding helix; other site
1266844003447	metal binding site 1 [ion binding]; metal-binding site
1266844003448	dimer interface [polypeptide binding]; other site
1266844003449	structural Zn2+ binding site [ion binding]; other site
1266844003450	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1266844003451	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1266844003452	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1266844003453	putative deacylase active site [active]
1266844003454	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; pfam10030
1266844003455	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1266844003456	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1266844003457	dimer interface [polypeptide binding]; other site
1266844003458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844003459	catalytic residue [active]
1266844003460	GMP synthase; Reviewed; Region: guaA; PRK00074
1266844003461	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1266844003462	AMP/PPi binding site [chemical binding]; other site
1266844003463	candidate oxyanion hole; other site
1266844003464	catalytic triad [active]
1266844003465	potential glutamine specificity residues [chemical binding]; other site
1266844003466	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1266844003467	ATP Binding subdomain [chemical binding]; other site
1266844003468	Ligand Binding sites [chemical binding]; other site
1266844003469	Dimerization subdomain; other site
1266844003470	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1266844003471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844003472	putative substrate translocation pore; other site
1266844003473	Phage shock protein B; Region: PspB; cl05946
1266844003474	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844003475	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1266844003476	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1266844003477	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1266844003478	catalytic residue [active]
1266844003479	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1266844003480	L-lactate permease; Region: Lactate_perm; cl00701
1266844003481	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1266844003482	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1266844003483	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
1266844003484	NADP binding site [chemical binding]; other site
1266844003485	homopentamer interface [polypeptide binding]; other site
1266844003486	substrate binding site [chemical binding]; other site
1266844003487	active site
1266844003488	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1266844003489	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
1266844003490	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1266844003491	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1266844003492	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1266844003493	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1266844003494	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1266844003495	catalytic residue [active]
1266844003496	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
1266844003497	Sporulation related domain; Region: SPOR; pfam05036
1266844003498	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1266844003499	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1266844003500	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1266844003501	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1266844003502	Walker A/P-loop; other site
1266844003503	ATP binding site [chemical binding]; other site
1266844003504	Q-loop/lid; other site
1266844003505	ABC transporter signature motif; other site
1266844003506	Walker B; other site
1266844003507	D-loop; other site
1266844003508	H-loop/switch region; other site
1266844003509	Uncharacterized conserved protein [Function unknown]; Region: COG1742
1266844003510	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1266844003511	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
1266844003512	Cl binding site [ion binding]; other site
1266844003513	oligomer interface [polypeptide binding]; other site
1266844003514	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1266844003515	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844003516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844003517	homodimer interface [polypeptide binding]; other site
1266844003518	catalytic residue [active]
1266844003519	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1266844003520	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1266844003521	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1266844003522	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1266844003523	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1266844003524	TPP-binding site [chemical binding]; other site
1266844003525	dimer interface [polypeptide binding]; other site
1266844003526	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1266844003527	PYR/PP interface [polypeptide binding]; other site
1266844003528	dimer interface [polypeptide binding]; other site
1266844003529	TPP binding site [chemical binding]; other site
1266844003530	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1266844003531	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
1266844003532	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1266844003533	putative active site [active]
1266844003534	catalytic residue [active]
1266844003535	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1266844003536	SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798
1266844003537	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1266844003538	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1266844003539	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266844003540	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1266844003541	active site
1266844003542	motif I; other site
1266844003543	motif II; other site
1266844003544	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1266844003545	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1266844003546	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1266844003547	putative active site [active]
1266844003548	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1266844003549	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1266844003550	active site
1266844003551	dimer interface [polypeptide binding]; other site
1266844003552	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1266844003553	AAA domain; Region: AAA_33; pfam13671
1266844003554	ATP-binding site [chemical binding]; other site
1266844003555	Gluconate-6-phosphate binding site [chemical binding]; other site
1266844003556	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
1266844003557	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1266844003558	intersubunit interface [polypeptide binding]; other site
1266844003559	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1266844003560	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1266844003561	Cl- selectivity filter; other site
1266844003562	Cl- binding residues [ion binding]; other site
1266844003563	pore gating glutamate residue; other site
1266844003564	dimer interface [polypeptide binding]; other site
1266844003565	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1266844003566	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1266844003567	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1266844003568	NAD(P) binding site [chemical binding]; other site
1266844003569	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1266844003570	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1266844003571	catalytic residue [active]
1266844003572	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
1266844003573	potassium uptake protein; Region: kup; TIGR00794
1266844003574	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
1266844003575	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844003576	FeS/SAM binding site; other site
1266844003577	HemN C-terminal domain; Region: HemN_C; pfam06969
1266844003578	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
1266844003579	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1266844003580	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1266844003581	Walker A/P-loop; other site
1266844003582	ATP binding site [chemical binding]; other site
1266844003583	Q-loop/lid; other site
1266844003584	ABC transporter signature motif; other site
1266844003585	Walker B; other site
1266844003586	D-loop; other site
1266844003587	H-loop/switch region; other site
1266844003588	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1266844003589	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1266844003590	Walker A/P-loop; other site
1266844003591	ATP binding site [chemical binding]; other site
1266844003592	Q-loop/lid; other site
1266844003593	ABC transporter signature motif; other site
1266844003594	Walker B; other site
1266844003595	D-loop; other site
1266844003596	H-loop/switch region; other site
1266844003597	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1266844003598	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1266844003599	TM-ABC transporter signature motif; other site
1266844003600	HEAT repeats; Region: HEAT_2; pfam13646
1266844003601	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1266844003602	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1266844003603	TM-ABC transporter signature motif; other site
1266844003604	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1266844003605	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1266844003606	putative ligand binding site [chemical binding]; other site
1266844003607	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1266844003608	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266844003609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266844003610	dimer interface [polypeptide binding]; other site
1266844003611	phosphorylation site [posttranslational modification]
1266844003612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844003613	ATP binding site [chemical binding]; other site
1266844003614	Mg2+ binding site [ion binding]; other site
1266844003615	G-X-G motif; other site
1266844003616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844003617	Response regulator receiver domain; Region: Response_reg; pfam00072
1266844003618	active site
1266844003619	phosphorylation site [posttranslational modification]
1266844003620	intermolecular recognition site; other site
1266844003621	dimerization interface [polypeptide binding]; other site
1266844003622	Response regulator receiver domain; Region: Response_reg; pfam00072
1266844003623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844003624	active site
1266844003625	phosphorylation site [posttranslational modification]
1266844003626	intermolecular recognition site; other site
1266844003627	dimerization interface [polypeptide binding]; other site
1266844003628	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1266844003629	DNA binding residues [nucleotide binding]
1266844003630	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1266844003631	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1266844003632	UreF; Region: UreF; pfam01730
1266844003633	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
1266844003634	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1266844003635	dimer interface [polypeptide binding]; other site
1266844003636	catalytic residues [active]
1266844003637	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1266844003638	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1266844003639	subunit interactions [polypeptide binding]; other site
1266844003640	active site
1266844003641	flap region; other site
1266844003642	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1266844003643	alpha-beta subunit interface [polypeptide binding]; other site
1266844003644	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1266844003645	alpha-gamma subunit interface [polypeptide binding]; other site
1266844003646	beta-gamma subunit interface [polypeptide binding]; other site
1266844003647	UreD urease accessory protein; Region: UreD; pfam01774
1266844003648	High-affinity nickel-transport protein; Region: NicO; cl00964
1266844003649	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1266844003650	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1266844003651	dimer interface [polypeptide binding]; other site
1266844003652	PYR/PP interface [polypeptide binding]; other site
1266844003653	TPP binding site [chemical binding]; other site
1266844003654	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1266844003655	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1266844003656	TPP-binding site [chemical binding]; other site
1266844003657	dimer interface [polypeptide binding]; other site
1266844003658	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
1266844003659	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1266844003660	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
1266844003661	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1266844003662	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1266844003663	heme binding site [chemical binding]; other site
1266844003664	ferroxidase pore; other site
1266844003665	ferroxidase diiron center [ion binding]; other site
1266844003666	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1266844003667	ArsC family; Region: ArsC; pfam03960
1266844003668	putative catalytic residues [active]
1266844003669	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1266844003670	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1266844003671	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1266844003672	dimerization interface [polypeptide binding]; other site
1266844003673	putative DNA binding site [nucleotide binding]; other site
1266844003674	putative Zn2+ binding site [ion binding]; other site
1266844003675	peroxiredoxin; Provisional; Region: PRK13189
1266844003676	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1266844003677	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1266844003678	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1266844003679	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1266844003680	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1266844003681	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1266844003682	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1266844003683	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1266844003684	ArsC family; Region: ArsC; pfam03960
1266844003685	catalytic residues [active]
1266844003686	Pirin-related protein [General function prediction only]; Region: COG1741
1266844003687	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1266844003688	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1266844003689	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1266844003690	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844003691	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1266844003692	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844003693	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844003694	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1266844003695	putative DNA binding site [nucleotide binding]; other site
1266844003696	putative Zn2+ binding site [ion binding]; other site
1266844003697	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
1266844003698	putative dimerization interface [polypeptide binding]; other site
1266844003699	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1266844003700	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1266844003701	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844003702	putative substrate translocation pore; other site
1266844003703	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1266844003704	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1266844003705	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1266844003706	Isochorismatase family; Region: Isochorismatase; pfam00857
1266844003707	catalytic triad [active]
1266844003708	conserved cis-peptide bond; other site
1266844003709	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1266844003710	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1266844003711	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1266844003712	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1266844003713	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1266844003714	Cytochrome c; Region: Cytochrom_C; pfam00034
1266844003715	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1266844003716	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1266844003717	Cytochrome c; Region: Cytochrom_C; pfam00034
1266844003718	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1266844003719	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1266844003720	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1266844003721	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1266844003722	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1266844003723	MarR family; Region: MarR_2; pfam12802
1266844003724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844003725	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1266844003726	NAD(P) binding site [chemical binding]; other site
1266844003727	active site
1266844003728	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1266844003729	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1266844003730	Protein required for attachment to host cells; Region: Host_attach; pfam10116
1266844003731	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1266844003732	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1266844003733	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1266844003734	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1266844003735	metal-binding site
1266844003736	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1266844003737	homotrimer interaction site [polypeptide binding]; other site
1266844003738	putative active site [active]
1266844003739	CHAP domain; Region: CHAP; cl17642
1266844003740	glycine dehydrogenase; Provisional; Region: PRK05367
1266844003741	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1266844003742	tetramer interface [polypeptide binding]; other site
1266844003743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844003744	catalytic residue [active]
1266844003745	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1266844003746	tetramer interface [polypeptide binding]; other site
1266844003747	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844003748	catalytic residue [active]
1266844003749	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1266844003750	lipoyl attachment site [posttranslational modification]; other site
1266844003751	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
1266844003752	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1266844003753	spermidine synthase; Provisional; Region: PRK00811
1266844003754	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844003755	S-adenosylmethionine binding site [chemical binding]; other site
1266844003756	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
1266844003757	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844003758	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844003759	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1266844003760	putative effector binding pocket; other site
1266844003761	dimerization interface [polypeptide binding]; other site
1266844003762	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1266844003763	active site
1266844003764	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1266844003765	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1266844003766	active site
1266844003767	(T/H)XGH motif; other site
1266844003768	DNA gyrase, A subunit; Region: gyrA; TIGR01063
1266844003769	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1266844003770	CAP-like domain; other site
1266844003771	active site
1266844003772	primary dimer interface [polypeptide binding]; other site
1266844003773	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1266844003774	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1266844003775	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1266844003776	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1266844003777	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1266844003778	FMN binding site [chemical binding]; other site
1266844003779	substrate binding site [chemical binding]; other site
1266844003780	putative catalytic residue [active]
1266844003781	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1266844003782	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1266844003783	RNase E interface [polypeptide binding]; other site
1266844003784	trimer interface [polypeptide binding]; other site
1266844003785	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1266844003786	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1266844003787	RNase E interface [polypeptide binding]; other site
1266844003788	trimer interface [polypeptide binding]; other site
1266844003789	active site
1266844003790	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1266844003791	putative nucleic acid binding region [nucleotide binding]; other site
1266844003792	G-X-X-G motif; other site
1266844003793	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1266844003794	RNA binding site [nucleotide binding]; other site
1266844003795	domain interface; other site
1266844003796	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1266844003797	16S/18S rRNA binding site [nucleotide binding]; other site
1266844003798	S13e-L30e interaction site [polypeptide binding]; other site
1266844003799	25S rRNA binding site [nucleotide binding]; other site
1266844003800	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
1266844003801	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1266844003802	RNA binding site [nucleotide binding]; other site
1266844003803	active site
1266844003804	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1266844003805	Permease; Region: Permease; pfam02405
1266844003806	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1266844003807	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1266844003808	Walker A/P-loop; other site
1266844003809	ATP binding site [chemical binding]; other site
1266844003810	Q-loop/lid; other site
1266844003811	ABC transporter signature motif; other site
1266844003812	Walker B; other site
1266844003813	D-loop; other site
1266844003814	H-loop/switch region; other site
1266844003815	mce related protein; Region: MCE; pfam02470
1266844003816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1266844003817	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1266844003818	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844003819	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
1266844003820	putative ADP-binding pocket [chemical binding]; other site
1266844003821	Clostridial hydrophobic W; Region: ChW; cl02763
1266844003822	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1266844003823	binding surface
1266844003824	TPR motif; other site
1266844003825	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1266844003826	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1266844003827	active site
1266844003828	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1266844003829	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844003830	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1266844003831	Sel1 repeat; Region: Sel1; cl02723
1266844003832	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1266844003833	Sel1-like repeats; Region: SEL1; smart00671
1266844003834	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1266844003835	Sel1-like repeats; Region: SEL1; smart00671
1266844003836	Sel1-like repeats; Region: SEL1; smart00671
1266844003837	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1266844003838	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1266844003839	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844003840	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
1266844003841	putative active site [active]
1266844003842	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1266844003843	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266844003844	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844003845	Walker A/P-loop; other site
1266844003846	ATP binding site [chemical binding]; other site
1266844003847	Q-loop/lid; other site
1266844003848	ABC transporter signature motif; other site
1266844003849	Walker B; other site
1266844003850	D-loop; other site
1266844003851	H-loop/switch region; other site
1266844003852	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1266844003853	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1266844003854	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1266844003855	substrate binding pocket [chemical binding]; other site
1266844003856	dimer interface [polypeptide binding]; other site
1266844003857	inhibitor binding site; inhibition site
1266844003858	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1266844003859	B12 binding site [chemical binding]; other site
1266844003860	cobalt ligand [ion binding]; other site
1266844003861	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1266844003862	Colicin V production protein; Region: Colicin_V; pfam02674
1266844003863	amidophosphoribosyltransferase; Provisional; Region: PRK09123
1266844003864	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1266844003865	active site
1266844003866	tetramer interface [polypeptide binding]; other site
1266844003867	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1266844003868	active site
1266844003869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1266844003870	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1266844003871	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1266844003872	mce related protein; Region: MCE; pfam02470
1266844003873	mce related protein; Region: MCE; pfam02470
1266844003874	mce related protein; Region: MCE; pfam02470
1266844003875	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
1266844003876	Paraquat-inducible protein A; Region: PqiA; pfam04403
1266844003877	Paraquat-inducible protein A; Region: PqiA; pfam04403
1266844003878	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1266844003879	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1266844003880	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1266844003881	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1266844003882	active site
1266844003883	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1266844003884	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1266844003885	ATP synthase subunit C; Region: ATP-synt_C; cl00466
1266844003886	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1266844003887	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1266844003888	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
1266844003889	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1266844003890	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1266844003891	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1266844003892	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
1266844003893	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1266844003894	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844003895	FeS/SAM binding site; other site
1266844003896	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1266844003897	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1266844003898	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1266844003899	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266844003900	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1266844003901	dimer interface [polypeptide binding]; other site
1266844003902	active site
1266844003903	metal binding site [ion binding]; metal-binding site
1266844003904	glutathione binding site [chemical binding]; other site
1266844003905	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1266844003906	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1266844003907	ATP binding site [chemical binding]; other site
1266844003908	Mg++ binding site [ion binding]; other site
1266844003909	motif III; other site
1266844003910	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844003911	nucleotide binding region [chemical binding]; other site
1266844003912	ATP-binding site [chemical binding]; other site
1266844003913	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
1266844003914	RNA binding site [nucleotide binding]; other site
1266844003915	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
1266844003916	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
1266844003917	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1266844003918	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1266844003919	23S rRNA interface [nucleotide binding]; other site
1266844003920	L3 interface [polypeptide binding]; other site
1266844003921	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844003922	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1266844003923	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844003924	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1266844003925	PhoU domain; Region: PhoU; pfam01895
1266844003926	PhoU domain; Region: PhoU; pfam01895
1266844003927	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
1266844003928	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1266844003929	Walker A/P-loop; other site
1266844003930	ATP binding site [chemical binding]; other site
1266844003931	Q-loop/lid; other site
1266844003932	ABC transporter signature motif; other site
1266844003933	Walker B; other site
1266844003934	D-loop; other site
1266844003935	H-loop/switch region; other site
1266844003936	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
1266844003937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844003938	dimer interface [polypeptide binding]; other site
1266844003939	conserved gate region; other site
1266844003940	putative PBP binding loops; other site
1266844003941	ABC-ATPase subunit interface; other site
1266844003942	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1266844003943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844003944	dimer interface [polypeptide binding]; other site
1266844003945	conserved gate region; other site
1266844003946	putative PBP binding loops; other site
1266844003947	ABC-ATPase subunit interface; other site
1266844003948	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1266844003949	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1266844003950	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1266844003951	NADP binding site [chemical binding]; other site
1266844003952	dimer interface [polypeptide binding]; other site
1266844003953	Predicted membrane protein [Function unknown]; Region: COG1289
1266844003954	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1266844003955	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1266844003956	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1266844003957	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1266844003958	protein binding site [polypeptide binding]; other site
1266844003959	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1266844003960	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1266844003961	active site
1266844003962	catalytic triad [active]
1266844003963	oxyanion hole [active]
1266844003964	OpgC protein; Region: OpgC_C; pfam10129
1266844003965	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1266844003966	antiporter inner membrane protein; Provisional; Region: PRK11670
1266844003967	Domain of unknown function DUF59; Region: DUF59; pfam01883
1266844003968	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1266844003969	Walker A motif; other site
1266844003970	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
1266844003971	Stringent starvation protein B; Region: SspB; cl01120
1266844003972	fumarate hydratase; Provisional; Region: PRK15389
1266844003973	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1266844003974	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1266844003975	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
1266844003976	dimer interface [polypeptide binding]; other site
1266844003977	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266844003978	metal binding site [ion binding]; metal-binding site
1266844003979	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
1266844003980	AntA/AntB antirepressor; Region: AntA; cl01430
1266844003981	Putative glucoamylase; Region: Glycoamylase; pfam10091
1266844003982	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1266844003983	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1266844003984	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1266844003985	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1266844003986	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1266844003987	active site
1266844003988	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1266844003989	dimer interface [polypeptide binding]; other site
1266844003990	substrate binding site [chemical binding]; other site
1266844003991	catalytic residues [active]
1266844003992	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1266844003993	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1266844003994	putative DNA binding site [nucleotide binding]; other site
1266844003995	putative Zn2+ binding site [ion binding]; other site
1266844003996	AsnC family; Region: AsnC_trans_reg; pfam01037
1266844003997	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1266844003998	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1266844003999	translation initiation factor IF-2; Region: IF-2; TIGR00487
1266844004000	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1266844004001	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1266844004002	G1 box; other site
1266844004003	putative GEF interaction site [polypeptide binding]; other site
1266844004004	GTP/Mg2+ binding site [chemical binding]; other site
1266844004005	Switch I region; other site
1266844004006	G2 box; other site
1266844004007	G3 box; other site
1266844004008	Switch II region; other site
1266844004009	G4 box; other site
1266844004010	G5 box; other site
1266844004011	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1266844004012	Translation-initiation factor 2; Region: IF-2; pfam11987
1266844004013	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1266844004014	hypothetical protein; Provisional; Region: PRK09190
1266844004015	Protein of unknown function (DUF448); Region: DUF448; pfam04296
1266844004016	putative RNA binding cleft [nucleotide binding]; other site
1266844004017	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1266844004018	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1266844004019	NusA N-terminal domain; Region: NusA_N; pfam08529
1266844004020	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1266844004021	RNA binding site [nucleotide binding]; other site
1266844004022	homodimer interface [polypeptide binding]; other site
1266844004023	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1266844004024	G-X-X-G motif; other site
1266844004025	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1266844004026	G-X-X-G motif; other site
1266844004027	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1266844004028	hypothetical protein; Provisional; Region: PRK14636
1266844004029	Sm and related proteins; Region: Sm_like; cl00259
1266844004030	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1266844004031	putative RNA binding site [nucleotide binding]; other site
1266844004032	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1266844004033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844004034	Walker A motif; other site
1266844004035	ATP binding site [chemical binding]; other site
1266844004036	Walker B motif; other site
1266844004037	arginine finger; other site
1266844004038	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844004039	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844004040	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1266844004041	putative effector binding pocket; other site
1266844004042	dimerization interface [polypeptide binding]; other site
1266844004043	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1266844004044	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1266844004045	substrate binding pocket [chemical binding]; other site
1266844004046	membrane-bound complex binding site; other site
1266844004047	hinge residues; other site
1266844004048	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1266844004049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844004050	dimer interface [polypeptide binding]; other site
1266844004051	conserved gate region; other site
1266844004052	putative PBP binding loops; other site
1266844004053	ABC-ATPase subunit interface; other site
1266844004054	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1266844004055	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844004056	Walker A/P-loop; other site
1266844004057	ATP binding site [chemical binding]; other site
1266844004058	Q-loop/lid; other site
1266844004059	ABC transporter signature motif; other site
1266844004060	Walker B; other site
1266844004061	D-loop; other site
1266844004062	H-loop/switch region; other site
1266844004063	aconitate hydratase; Validated; Region: PRK09277
1266844004064	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1266844004065	substrate binding site [chemical binding]; other site
1266844004066	ligand binding site [chemical binding]; other site
1266844004067	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1266844004068	substrate binding site [chemical binding]; other site
1266844004069	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
1266844004070	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844004071	Walker A/P-loop; other site
1266844004072	ATP binding site [chemical binding]; other site
1266844004073	Q-loop/lid; other site
1266844004074	ABC transporter signature motif; other site
1266844004075	Walker B; other site
1266844004076	D-loop; other site
1266844004077	H-loop/switch region; other site
1266844004078	CcmB protein; Region: CcmB; pfam03379
1266844004079	hypothetical protein; Provisional; Region: PRK10316
1266844004080	YfdX protein; Region: YfdX; pfam10938
1266844004081	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1266844004082	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
1266844004083	dimer interface [polypeptide binding]; other site
1266844004084	active site
1266844004085	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1266844004086	catalytic residues [active]
1266844004087	substrate binding site [chemical binding]; other site
1266844004088	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1266844004089	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1266844004090	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1266844004091	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1266844004092	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1266844004093	trimer interface [polypeptide binding]; other site
1266844004094	active site
1266844004095	dimer interface [polypeptide binding]; other site
1266844004096	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1266844004097	carboxyltransferase (CT) interaction site; other site
1266844004098	biotinylation site [posttranslational modification]; other site
1266844004099	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1266844004100	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1266844004101	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1266844004102	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1266844004103	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1266844004104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844004105	putative substrate translocation pore; other site
1266844004106	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844004107	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1266844004108	ThiC-associated domain; Region: ThiC-associated; pfam13667
1266844004109	ThiC family; Region: ThiC; pfam01964
1266844004110	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1266844004111	Iron permease FTR1 family; Region: FTR1; cl00475
1266844004112	Fe2+ transport protein; Region: Iron_transport; cl01377
1266844004113	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1266844004114	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
1266844004115	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
1266844004116	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1266844004117	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1266844004118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844004119	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1266844004120	dimerization interface [polypeptide binding]; other site
1266844004121	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
1266844004122	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1266844004123	inhibitor-cofactor binding pocket; inhibition site
1266844004124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844004125	catalytic residue [active]
1266844004126	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
1266844004127	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1266844004128	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1266844004129	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1266844004130	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1266844004131	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1266844004132	GatB domain; Region: GatB_Yqey; smart00845
1266844004133	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1266844004134	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266844004135	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844004136	Walker A/P-loop; other site
1266844004137	ATP binding site [chemical binding]; other site
1266844004138	Q-loop/lid; other site
1266844004139	ABC transporter signature motif; other site
1266844004140	Walker B; other site
1266844004141	D-loop; other site
1266844004142	H-loop/switch region; other site
1266844004143	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1266844004144	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1266844004145	minor groove reading motif; other site
1266844004146	helix-hairpin-helix signature motif; other site
1266844004147	substrate binding pocket [chemical binding]; other site
1266844004148	active site
1266844004149	ferrochelatase; Reviewed; Region: hemH; PRK00035
1266844004150	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1266844004151	C-terminal domain interface [polypeptide binding]; other site
1266844004152	active site
1266844004153	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1266844004154	active site
1266844004155	N-terminal domain interface [polypeptide binding]; other site
1266844004156	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1266844004157	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1266844004158	minor groove reading motif; other site
1266844004159	helix-hairpin-helix signature motif; other site
1266844004160	substrate binding pocket [chemical binding]; other site
1266844004161	active site
1266844004162	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
1266844004163	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1266844004164	DNA binding and oxoG recognition site [nucleotide binding]
1266844004165	Protein of unknown function (DUF721); Region: DUF721; cl02324
1266844004166	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1266844004167	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1266844004168	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1266844004169	catalytic residue [active]
1266844004170	Sporulation related domain; Region: SPOR; cl10051
1266844004171	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
1266844004172	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1266844004173	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1266844004174	HIGH motif; other site
1266844004175	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1266844004176	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1266844004177	active site
1266844004178	KMSKS motif; other site
1266844004179	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1266844004180	tRNA binding surface [nucleotide binding]; other site
1266844004181	Lipopolysaccharide-assembly; Region: LptE; pfam04390
1266844004182	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
1266844004183	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1266844004184	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1266844004185	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844004186	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844004187	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1266844004188	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1266844004189	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1266844004190	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1266844004191	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1266844004192	Ligand binding site [chemical binding]; other site
1266844004193	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1266844004194	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1266844004195	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1266844004196	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1266844004197	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1266844004198	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1266844004199	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844004200	FeS/SAM binding site; other site
1266844004201	HemN C-terminal domain; Region: HemN_C; pfam06969
1266844004202	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1266844004203	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1266844004204	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1266844004205	ligand binding site [chemical binding]; other site
1266844004206	flexible hinge region; other site
1266844004207	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1266844004208	putative switch regulator; other site
1266844004209	non-specific DNA interactions [nucleotide binding]; other site
1266844004210	DNA binding site [nucleotide binding]
1266844004211	sequence specific DNA binding site [nucleotide binding]; other site
1266844004212	putative cAMP binding site [chemical binding]; other site
1266844004213	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1266844004214	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1266844004215	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1266844004216	protein binding site [polypeptide binding]; other site
1266844004217	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1266844004218	protein binding site [polypeptide binding]; other site
1266844004219	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1266844004220	nucleoside/Zn binding site; other site
1266844004221	dimer interface [polypeptide binding]; other site
1266844004222	catalytic motif [active]
1266844004223	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1266844004224	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1266844004225	catalytic triad [active]
1266844004226	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1266844004227	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1266844004228	RNA binding surface [nucleotide binding]; other site
1266844004229	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1266844004230	active site
1266844004231	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1266844004232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844004233	S-adenosylmethionine binding site [chemical binding]; other site
1266844004234	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1266844004235	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1266844004236	dimer interface [polypeptide binding]; other site
1266844004237	ssDNA binding site [nucleotide binding]; other site
1266844004238	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1266844004239	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1266844004240	O-Antigen ligase; Region: Wzy_C; pfam04932
1266844004241	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1266844004242	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1266844004243	active site
1266844004244	catalytic residues [active]
1266844004245	DNA binding site [nucleotide binding]
1266844004246	Int/Topo IB signature motif; other site
1266844004247	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1266844004248	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1266844004249	catalytic residues [active]
1266844004250	catalytic nucleophile [active]
1266844004251	Presynaptic Site I dimer interface [polypeptide binding]; other site
1266844004252	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1266844004253	Synaptic Flat tetramer interface [polypeptide binding]; other site
1266844004254	Synaptic Site I dimer interface [polypeptide binding]; other site
1266844004255	DNA binding site [nucleotide binding]
1266844004256	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1266844004257	DNA-binding interface [nucleotide binding]; DNA binding site
1266844004258	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1266844004259	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266844004260	ATP binding site [chemical binding]; other site
1266844004261	putative Mg++ binding site [ion binding]; other site
1266844004262	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844004263	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1266844004264	putative ADP-binding pocket [chemical binding]; other site
1266844004265	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1266844004266	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1266844004267	active site
1266844004268	HIGH motif; other site
1266844004269	dimer interface [polypeptide binding]; other site
1266844004270	KMSKS motif; other site
1266844004271	protease TldD; Provisional; Region: tldD; PRK10735
1266844004272	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1266844004273	catalytic core [active]
1266844004274	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1266844004275	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1266844004276	NAD binding site [chemical binding]; other site
1266844004277	substrate binding site [chemical binding]; other site
1266844004278	homodimer interface [polypeptide binding]; other site
1266844004279	active site
1266844004280	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1266844004281	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1266844004282	substrate binding site; other site
1266844004283	tetramer interface; other site
1266844004284	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1266844004285	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1266844004286	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1266844004287	NADP binding site [chemical binding]; other site
1266844004288	active site
1266844004289	putative substrate binding site [chemical binding]; other site
1266844004290	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1266844004291	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
1266844004292	Probable Catalytic site; other site
1266844004293	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1266844004294	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1266844004295	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1266844004296	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1266844004297	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1266844004298	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1266844004299	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844004300	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1266844004301	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
1266844004302	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1266844004303	putative C-terminal domain interface [polypeptide binding]; other site
1266844004304	putative GSH binding site (G-site) [chemical binding]; other site
1266844004305	putative dimer interface [polypeptide binding]; other site
1266844004306	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
1266844004307	putative N-terminal domain interface [polypeptide binding]; other site
1266844004308	putative dimer interface [polypeptide binding]; other site
1266844004309	putative substrate binding pocket (H-site) [chemical binding]; other site
1266844004310	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1266844004311	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1266844004312	Ligand Binding Site [chemical binding]; other site
1266844004313	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1266844004314	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1266844004315	catalytic loop [active]
1266844004316	iron binding site [ion binding]; other site
1266844004317	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1266844004318	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
1266844004319	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1266844004320	catalytic residue [active]
1266844004321	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1266844004322	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1266844004323	catalytic residue [active]
1266844004324	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
1266844004325	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1266844004326	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1266844004327	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1266844004328	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1266844004329	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1266844004330	active site
1266844004331	HIGH motif; other site
1266844004332	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1266844004333	KMSKS motif; other site
1266844004334	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1266844004335	tRNA binding surface [nucleotide binding]; other site
1266844004336	anticodon binding site; other site
1266844004337	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1266844004338	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1266844004339	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1266844004340	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1266844004341	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1266844004342	catalytic residues [active]
1266844004343	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
1266844004344	Family description; Region: UvrD_C_2; pfam13538
1266844004345	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1266844004346	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
1266844004347	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1266844004348	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1266844004349	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266844004350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844004351	active site
1266844004352	phosphorylation site [posttranslational modification]
1266844004353	intermolecular recognition site; other site
1266844004354	dimerization interface [polypeptide binding]; other site
1266844004355	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266844004356	DNA binding site [nucleotide binding]
1266844004357	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
1266844004358	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1266844004359	active site
1266844004360	substrate binding site [chemical binding]; other site
1266844004361	metal binding site [ion binding]; metal-binding site
1266844004362	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1266844004363	dihydropteroate synthase; Region: DHPS; TIGR01496
1266844004364	substrate binding pocket [chemical binding]; other site
1266844004365	dimer interface [polypeptide binding]; other site
1266844004366	inhibitor binding site; inhibition site
1266844004367	FtsH Extracellular; Region: FtsH_ext; pfam06480
1266844004368	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1266844004369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844004370	Walker A motif; other site
1266844004371	ATP binding site [chemical binding]; other site
1266844004372	Walker B motif; other site
1266844004373	arginine finger; other site
1266844004374	Peptidase family M41; Region: Peptidase_M41; pfam01434
1266844004375	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1266844004376	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1266844004377	Ligand Binding Site [chemical binding]; other site
1266844004378	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1266844004379	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1266844004380	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1266844004381	ligand binding site [chemical binding]; other site
1266844004382	translocation protein TolB; Provisional; Region: tolB; PRK05137
1266844004383	TolB amino-terminal domain; Region: TolB_N; pfam04052
1266844004384	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1266844004385	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1266844004386	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1266844004387	TolR protein; Region: tolR; TIGR02801
1266844004388	TolQ protein; Region: tolQ; TIGR02796
1266844004389	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1266844004390	active site
1266844004391	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1266844004392	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844004393	Walker A motif; other site
1266844004394	ATP binding site [chemical binding]; other site
1266844004395	Walker B motif; other site
1266844004396	arginine finger; other site
1266844004397	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1266844004398	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1266844004399	RuvA N terminal domain; Region: RuvA_N; pfam01330
1266844004400	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1266844004401	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1266844004402	active site
1266844004403	putative DNA-binding cleft [nucleotide binding]; other site
1266844004404	dimer interface [polypeptide binding]; other site
1266844004405	hypothetical protein; Validated; Region: PRK00110
1266844004406	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1266844004407	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1266844004408	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1266844004409	nucleotide binding region [chemical binding]; other site
1266844004410	ATP-binding site [chemical binding]; other site
1266844004411	SEC-C motif; Region: SEC-C; pfam02810
1266844004412	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1266844004413	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1266844004414	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1266844004415	heterotetramer interface [polypeptide binding]; other site
1266844004416	active site pocket [active]
1266844004417	cleavage site
1266844004418	RDD family; Region: RDD; pfam06271
1266844004419	putative mechanosensitive channel protein; Provisional; Region: PRK11465
1266844004420	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1266844004421	Biofilm formation and stress response factor; Region: BsmA; pfam10014
1266844004422	chaperone protein DnaJ; Provisional; Region: PRK14299
1266844004423	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1266844004424	HSP70 interaction site [polypeptide binding]; other site
1266844004425	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1266844004426	substrate binding site [polypeptide binding]; other site
1266844004427	dimer interface [polypeptide binding]; other site
1266844004428	Membrane fusogenic activity; Region: BMFP; pfam04380
1266844004429	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
1266844004430	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1266844004431	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1266844004432	H+ Antiporter protein; Region: 2A0121; TIGR00900
1266844004433	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1266844004434	IHF dimer interface [polypeptide binding]; other site
1266844004435	IHF - DNA interface [nucleotide binding]; other site
1266844004436	Rhamnan synthesis protein F; Region: RgpF; pfam05045
1266844004437	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1266844004438	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844004439	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844004440	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
1266844004441	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844004442	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1266844004443	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1266844004444	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1266844004445	active site
1266844004446	NAD synthetase; Reviewed; Region: nadE; PRK02628
1266844004447	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1266844004448	multimer interface [polypeptide binding]; other site
1266844004449	active site
1266844004450	catalytic triad [active]
1266844004451	protein interface 1 [polypeptide binding]; other site
1266844004452	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1266844004453	homodimer interface [polypeptide binding]; other site
1266844004454	NAD binding pocket [chemical binding]; other site
1266844004455	ATP binding pocket [chemical binding]; other site
1266844004456	Mg binding site [ion binding]; other site
1266844004457	active-site loop [active]
1266844004458	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1266844004459	putative active site pocket [active]
1266844004460	4-fold oligomerization interface [polypeptide binding]; other site
1266844004461	metal binding residues [ion binding]; metal-binding site
1266844004462	3-fold/trimer interface [polypeptide binding]; other site
1266844004463	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1266844004464	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1266844004465	putative active site [active]
1266844004466	oxyanion strand; other site
1266844004467	catalytic triad [active]
1266844004468	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1266844004469	Coenzyme A binding pocket [chemical binding]; other site
1266844004470	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1266844004471	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1266844004472	catalytic residues [active]
1266844004473	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1266844004474	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1266844004475	substrate binding site [chemical binding]; other site
1266844004476	glutamase interaction surface [polypeptide binding]; other site
1266844004477	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1266844004478	metal binding site [ion binding]; metal-binding site
1266844004479	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1266844004480	nucleotide binding site/active site [active]
1266844004481	HIT family signature motif; other site
1266844004482	catalytic residue [active]
1266844004483	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1266844004484	putative FMN binding site [chemical binding]; other site
1266844004485	hypothetical protein; Provisional; Region: PRK09126
1266844004486	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1266844004487	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
1266844004488	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
1266844004489	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1266844004490	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1266844004491	putative C-terminal domain interface [polypeptide binding]; other site
1266844004492	putative GSH binding site (G-site) [chemical binding]; other site
1266844004493	putative dimer interface [polypeptide binding]; other site
1266844004494	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
1266844004495	putative N-terminal domain interface [polypeptide binding]; other site
1266844004496	putative dimer interface [polypeptide binding]; other site
1266844004497	putative substrate binding pocket (H-site) [chemical binding]; other site
1266844004498	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1266844004499	ParB-like nuclease domain; Region: ParB; smart00470
1266844004500	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1266844004501	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1266844004502	P-loop; other site
1266844004503	Magnesium ion binding site [ion binding]; other site
1266844004504	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1266844004505	Magnesium ion binding site [ion binding]; other site
1266844004506	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1266844004507	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1266844004508	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1266844004509	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1266844004510	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1266844004511	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1266844004512	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1266844004513	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1266844004514	G1 box; other site
1266844004515	GTP/Mg2+ binding site [chemical binding]; other site
1266844004516	Switch I region; other site
1266844004517	G2 box; other site
1266844004518	Switch II region; other site
1266844004519	G3 box; other site
1266844004520	G4 box; other site
1266844004521	G5 box; other site
1266844004522	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1266844004523	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1266844004524	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1266844004525	DNA binding site [nucleotide binding]
1266844004526	active site
1266844004527	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1266844004528	major facilitator superfamily transporter; Provisional; Region: PRK05122
1266844004529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844004530	putative substrate translocation pore; other site
1266844004531	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1266844004532	dimer interface [polypeptide binding]; other site
1266844004533	ADP-ribose binding site [chemical binding]; other site
1266844004534	active site
1266844004535	nudix motif; other site
1266844004536	metal binding site [ion binding]; metal-binding site
1266844004537	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
1266844004538	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1266844004539	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266844004540	motif II; other site
1266844004541	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1266844004542	substrate binding site [chemical binding]; other site
1266844004543	active site
1266844004544	Maf-like protein; Region: Maf; pfam02545
1266844004545	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1266844004546	active site
1266844004547	dimer interface [polypeptide binding]; other site
1266844004548	hypothetical protein; Validated; Region: PRK00124
1266844004549	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1266844004550	dimer interface [polypeptide binding]; other site
1266844004551	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1266844004552	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844004553	putative substrate translocation pore; other site
1266844004554	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1266844004555	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1266844004556	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1266844004557	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1266844004558	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1266844004559	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1266844004560	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1266844004561	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1266844004562	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1266844004563	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1266844004564	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1266844004565	AAA ATPase domain; Region: AAA_16; pfam13191
1266844004566	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
1266844004567	Uncharacterized conserved protein [Function unknown]; Region: COG3410
1266844004568	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
1266844004569	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1266844004570	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
1266844004571	putative FMN binding site [chemical binding]; other site
1266844004572	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1266844004573	Glycoprotease family; Region: Peptidase_M22; pfam00814
1266844004574	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1266844004575	Coenzyme A binding pocket [chemical binding]; other site
1266844004576	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1266844004577	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1266844004578	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1266844004579	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1266844004580	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1266844004581	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1266844004582	generic binding surface II; other site
1266844004583	generic binding surface I; other site
1266844004584	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
1266844004585	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1266844004586	catalytic residue [active]
1266844004587	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1266844004588	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1266844004589	NAD(P) binding site [chemical binding]; other site
1266844004590	catalytic residues [active]
1266844004591	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1266844004592	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1266844004593	NAD binding site [chemical binding]; other site
1266844004594	substrate binding site [chemical binding]; other site
1266844004595	catalytic Zn binding site [ion binding]; other site
1266844004596	tetramer interface [polypeptide binding]; other site
1266844004597	structural Zn binding site [ion binding]; other site
1266844004598	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1266844004599	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1266844004600	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1266844004601	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1266844004602	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1266844004603	ligand binding site [chemical binding]; other site
1266844004604	homodimer interface [polypeptide binding]; other site
1266844004605	NAD(P) binding site [chemical binding]; other site
1266844004606	trimer interface B [polypeptide binding]; other site
1266844004607	trimer interface A [polypeptide binding]; other site
1266844004608	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1266844004609	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1266844004610	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1266844004611	Iron-sulfur protein interface; other site
1266844004612	proximal quinone binding site [chemical binding]; other site
1266844004613	SdhD (CybS) interface [polypeptide binding]; other site
1266844004614	proximal heme binding site [chemical binding]; other site
1266844004615	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
1266844004616	putative SdhC subunit interface [polypeptide binding]; other site
1266844004617	putative proximal heme binding site [chemical binding]; other site
1266844004618	putative Iron-sulfur protein interface [polypeptide binding]; other site
1266844004619	putative proximal quinone binding site; other site
1266844004620	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
1266844004621	L-aspartate oxidase; Provisional; Region: PRK06175
1266844004622	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1266844004623	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1266844004624	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1266844004625	Putative phosphatase (DUF442); Region: DUF442; cl17385
1266844004626	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1266844004627	EamA-like transporter family; Region: EamA; pfam00892
1266844004628	Phosphoglycerate kinase; Region: PGK; pfam00162
1266844004629	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1266844004630	substrate binding site [chemical binding]; other site
1266844004631	hinge regions; other site
1266844004632	ADP binding site [chemical binding]; other site
1266844004633	catalytic site [active]
1266844004634	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1266844004635	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1266844004636	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1266844004637	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1266844004638	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1266844004639	TPP-binding site [chemical binding]; other site
1266844004640	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1266844004641	PYR/PP interface [polypeptide binding]; other site
1266844004642	dimer interface [polypeptide binding]; other site
1266844004643	TPP binding site [chemical binding]; other site
1266844004644	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1266844004645	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1266844004646	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1266844004647	substrate-cofactor binding pocket; other site
1266844004648	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844004649	catalytic residue [active]
1266844004650	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1266844004651	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1266844004652	catalytic residues [active]
1266844004653	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
1266844004654	recombinase A; Provisional; Region: recA; PRK09354
1266844004655	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1266844004656	hexamer interface [polypeptide binding]; other site
1266844004657	Walker A motif; other site
1266844004658	ATP binding site [chemical binding]; other site
1266844004659	Walker B motif; other site
1266844004660	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1266844004661	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1266844004662	Coenzyme A binding pocket [chemical binding]; other site
1266844004663	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1266844004664	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
1266844004665	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
1266844004666	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
1266844004667	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1266844004668	Ligand binding site; other site
1266844004669	DXD motif; other site
1266844004670	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
1266844004671	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1266844004672	active site
1266844004673	dimer interface [polypeptide binding]; other site
1266844004674	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1266844004675	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844004676	putative substrate translocation pore; other site
1266844004677	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
1266844004678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844004679	Walker A motif; other site
1266844004680	ATP binding site [chemical binding]; other site
1266844004681	Walker B motif; other site
1266844004682	arginine finger; other site
1266844004683	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1266844004684	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
1266844004685	hypothetical protein; Validated; Region: PRK00153
1266844004686	recombination protein RecR; Reviewed; Region: recR; PRK00076
1266844004687	RecR protein; Region: RecR; pfam02132
1266844004688	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1266844004689	putative active site [active]
1266844004690	putative metal-binding site [ion binding]; other site
1266844004691	tetramer interface [polypeptide binding]; other site
1266844004692	short chain dehydrogenase; Provisional; Region: PRK09134
1266844004693	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844004694	NAD(P) binding site [chemical binding]; other site
1266844004695	active site
1266844004696	Dihydroneopterin aldolase; Region: FolB; pfam02152
1266844004697	active site
1266844004698	TIGR02300 family protein; Region: FYDLN_acid
1266844004699	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
1266844004700	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1266844004701	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1266844004702	hinge; other site
1266844004703	active site
1266844004704	cytidylate kinase; Provisional; Region: cmk; PRK00023
1266844004705	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1266844004706	CMP-binding site; other site
1266844004707	The sites determining sugar specificity; other site
1266844004708	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1266844004709	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1266844004710	RNA binding site [nucleotide binding]; other site
1266844004711	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1266844004712	RNA binding site [nucleotide binding]; other site
1266844004713	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1266844004714	RNA binding site [nucleotide binding]; other site
1266844004715	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
1266844004716	RNA binding site [nucleotide binding]; other site
1266844004717	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
1266844004718	RNA binding site [nucleotide binding]; other site
1266844004719	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1266844004720	RNA binding site [nucleotide binding]; other site
1266844004721	Major royal jelly protein; Region: MRJP; pfam03022
1266844004722	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1266844004723	active site
1266844004724	dimerization interface [polypeptide binding]; other site
1266844004725	ribonuclease PH; Reviewed; Region: rph; PRK00173
1266844004726	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1266844004727	hexamer interface [polypeptide binding]; other site
1266844004728	active site
1266844004729	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1266844004730	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1266844004731	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
1266844004732	Transglycosylase; Region: Transgly; pfam00912
1266844004733	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1266844004734	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1266844004735	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1266844004736	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1266844004737	RF-1 domain; Region: RF-1; pfam00472
1266844004738	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1266844004739	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1266844004740	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1266844004741	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1266844004742	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1266844004743	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1266844004744	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1266844004745	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1266844004746	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1266844004747	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1266844004748	rod shape-determining protein MreC; Provisional; Region: PRK13922
1266844004749	rod shape-determining protein MreC; Region: MreC; pfam04085
1266844004750	rod shape-determining protein MreB; Provisional; Region: PRK13927
1266844004751	MreB and similar proteins; Region: MreB_like; cd10225
1266844004752	nucleotide binding site [chemical binding]; other site
1266844004753	Mg binding site [ion binding]; other site
1266844004754	putative protofilament interaction site [polypeptide binding]; other site
1266844004755	RodZ interaction site [polypeptide binding]; other site
1266844004756	2-isopropylmalate synthase; Validated; Region: PRK00915
1266844004757	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1266844004758	active site
1266844004759	catalytic residues [active]
1266844004760	metal binding site [ion binding]; metal-binding site
1266844004761	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1266844004762	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
1266844004763	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1266844004764	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1266844004765	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1266844004766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844004767	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1266844004768	putative substrate translocation pore; other site
1266844004769	PAS fold; Region: PAS_7; pfam12860
1266844004770	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266844004771	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266844004772	dimer interface [polypeptide binding]; other site
1266844004773	phosphorylation site [posttranslational modification]
1266844004774	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844004775	ATP binding site [chemical binding]; other site
1266844004776	Mg2+ binding site [ion binding]; other site
1266844004777	G-X-G motif; other site
1266844004778	Response regulator receiver domain; Region: Response_reg; pfam00072
1266844004779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844004780	active site
1266844004781	phosphorylation site [posttranslational modification]
1266844004782	intermolecular recognition site; other site
1266844004783	dimerization interface [polypeptide binding]; other site
1266844004784	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1266844004785	active site
1266844004786	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1266844004787	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1266844004788	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
1266844004789	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
1266844004790	MOFRL family; Region: MOFRL; pfam05161
1266844004791	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1266844004792	ligand binding site [chemical binding]; other site
1266844004793	active site
1266844004794	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1266844004795	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1266844004796	Cytochrome c; Region: Cytochrom_C; pfam00034
1266844004797	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1266844004798	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
1266844004799	Trp docking motif [polypeptide binding]; other site
1266844004800	cytochrome domain interface [polypeptide binding]; other site
1266844004801	active site
1266844004802	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1266844004803	Cytochrome c; Region: Cytochrom_C; pfam00034
1266844004804	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
1266844004805	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1266844004806	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1266844004807	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
1266844004808	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1266844004809	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1266844004810	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1266844004811	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1266844004812	D-pathway; other site
1266844004813	Putative ubiquinol binding site [chemical binding]; other site
1266844004814	Low-spin heme (heme b) binding site [chemical binding]; other site
1266844004815	Putative water exit pathway; other site
1266844004816	Binuclear center (heme o3/CuB) [ion binding]; other site
1266844004817	K-pathway; other site
1266844004818	Putative proton exit pathway; other site
1266844004819	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1266844004820	Subunit I/III interface [polypeptide binding]; other site
1266844004821	Subunit III/IV interface [polypeptide binding]; other site
1266844004822	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
1266844004823	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1266844004824	4Fe-4S binding domain; Region: Fer4; pfam00037
1266844004825	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
1266844004826	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1266844004827	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844004828	nucleotide binding region [chemical binding]; other site
1266844004829	ATP-binding site [chemical binding]; other site
1266844004830	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1266844004831	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1266844004832	interface (dimer of trimers) [polypeptide binding]; other site
1266844004833	Substrate-binding/catalytic site; other site
1266844004834	Zn-binding sites [ion binding]; other site
1266844004835	MarR family; Region: MarR; pfam01047
1266844004836	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
1266844004837	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1266844004838	Mg++ binding site [ion binding]; other site
1266844004839	putative catalytic motif [active]
1266844004840	putative substrate binding site [chemical binding]; other site
1266844004841	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1266844004842	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1266844004843	NAD(P) binding site [chemical binding]; other site
1266844004844	homodimer interface [polypeptide binding]; other site
1266844004845	substrate binding site [chemical binding]; other site
1266844004846	active site
1266844004847	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1266844004848	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1266844004849	inhibitor-cofactor binding pocket; inhibition site
1266844004850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844004851	catalytic residue [active]
1266844004852	Lamin Tail Domain; Region: LTD; pfam00932
1266844004853	dihydroorotase; Validated; Region: PRK09060
1266844004854	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1266844004855	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
1266844004856	active site
1266844004857	glutathione reductase; Validated; Region: PRK06116
1266844004858	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1266844004859	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1266844004860	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1266844004861	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1266844004862	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1266844004863	FAD binding pocket [chemical binding]; other site
1266844004864	FAD binding motif [chemical binding]; other site
1266844004865	phosphate binding motif [ion binding]; other site
1266844004866	beta-alpha-beta structure motif; other site
1266844004867	NAD binding pocket [chemical binding]; other site
1266844004868	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1266844004869	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266844004870	ATP binding site [chemical binding]; other site
1266844004871	putative Mg++ binding site [ion binding]; other site
1266844004872	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1266844004873	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844004874	nucleotide binding region [chemical binding]; other site
1266844004875	ATP-binding site [chemical binding]; other site
1266844004876	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
1266844004877	short chain dehydrogenase; Provisional; Region: PRK06197
1266844004878	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844004879	NAD(P) binding site [chemical binding]; other site
1266844004880	active site
1266844004881	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1266844004882	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1266844004883	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1266844004884	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1266844004885	malate dehydrogenase; Provisional; Region: PRK13529
1266844004886	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1266844004887	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1266844004888	NAD(P) binding site [chemical binding]; other site
1266844004889	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1266844004890	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1266844004891	putative homodimer interface [polypeptide binding]; other site
1266844004892	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1266844004893	heterodimer interface [polypeptide binding]; other site
1266844004894	homodimer interface [polypeptide binding]; other site
1266844004895	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
1266844004896	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
1266844004897	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1266844004898	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1266844004899	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1266844004900	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1266844004901	beta subunit interaction interface [polypeptide binding]; other site
1266844004902	Walker A motif; other site
1266844004903	ATP binding site [chemical binding]; other site
1266844004904	Walker B motif; other site
1266844004905	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1266844004906	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1266844004907	core domain interface [polypeptide binding]; other site
1266844004908	delta subunit interface [polypeptide binding]; other site
1266844004909	epsilon subunit interface [polypeptide binding]; other site
1266844004910	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1266844004911	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1266844004912	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1266844004913	alpha subunit interaction interface [polypeptide binding]; other site
1266844004914	Walker A motif; other site
1266844004915	ATP binding site [chemical binding]; other site
1266844004916	Walker B motif; other site
1266844004917	inhibitor binding site; inhibition site
1266844004918	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1266844004919	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
1266844004920	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1266844004921	gamma subunit interface [polypeptide binding]; other site
1266844004922	epsilon subunit interface [polypeptide binding]; other site
1266844004923	LBP interface [polypeptide binding]; other site
1266844004924	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1266844004925	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1266844004926	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1266844004927	catalytic site [active]
1266844004928	putative active site [active]
1266844004929	putative substrate binding site [chemical binding]; other site
1266844004930	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
1266844004931	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1266844004932	substrate binding site [chemical binding]; other site
1266844004933	ATP binding site [chemical binding]; other site
1266844004934	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1266844004935	GcrA cell cycle regulator; Region: GcrA; cl11564
1266844004936	GcrA cell cycle regulator; Region: GcrA; cl11564
1266844004937	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1266844004938	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1266844004939	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844004940	Walker A/P-loop; other site
1266844004941	ATP binding site [chemical binding]; other site
1266844004942	Q-loop/lid; other site
1266844004943	ABC transporter signature motif; other site
1266844004944	Walker B; other site
1266844004945	D-loop; other site
1266844004946	H-loop/switch region; other site
1266844004947	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1266844004948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844004949	dimer interface [polypeptide binding]; other site
1266844004950	conserved gate region; other site
1266844004951	putative PBP binding loops; other site
1266844004952	ABC-ATPase subunit interface; other site
1266844004953	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1266844004954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844004955	dimer interface [polypeptide binding]; other site
1266844004956	conserved gate region; other site
1266844004957	putative PBP binding loops; other site
1266844004958	ABC-ATPase subunit interface; other site
1266844004959	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
1266844004960	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
1266844004961	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1266844004962	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1266844004963	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1266844004964	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1266844004965	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1266844004966	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1266844004967	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1266844004968	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1266844004969	ethanolamine permease; Region: 2A0305; TIGR00908
1266844004970	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1266844004971	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1266844004972	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844004973	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1266844004974	Protein export membrane protein; Region: SecD_SecF; cl14618
1266844004975	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1266844004976	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1266844004977	DNA-binding site [nucleotide binding]; DNA binding site
1266844004978	RNA-binding motif; other site
1266844004979	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1266844004980	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844004981	N-terminal plug; other site
1266844004982	ligand-binding site [chemical binding]; other site
1266844004983	hypothetical protein; Provisional; Region: PRK09945
1266844004984	hypothetical protein; Provisional; Region: PRK09945
1266844004985	Hint domain; Region: Hint_2; pfam13403
1266844004986	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1266844004987	formamidase; Provisional; Region: amiF; PRK13287
1266844004988	aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565
1266844004989	multimer interface [polypeptide binding]; other site
1266844004990	active site
1266844004991	catalytic triad [active]
1266844004992	dimer interface [polypeptide binding]; other site
1266844004993	Response regulator receiver domain; Region: Response_reg; pfam00072
1266844004994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844004995	active site
1266844004996	phosphorylation site [posttranslational modification]
1266844004997	intermolecular recognition site; other site
1266844004998	dimerization interface [polypeptide binding]; other site
1266844004999	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1266844005000	DNA binding residues [nucleotide binding]
1266844005001	dimerization interface [polypeptide binding]; other site
1266844005002	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1266844005003	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266844005004	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266844005005	dimer interface [polypeptide binding]; other site
1266844005006	phosphorylation site [posttranslational modification]
1266844005007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844005008	ATP binding site [chemical binding]; other site
1266844005009	Mg2+ binding site [ion binding]; other site
1266844005010	G-X-G motif; other site
1266844005011	Response regulator receiver domain; Region: Response_reg; pfam00072
1266844005012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844005013	active site
1266844005014	phosphorylation site [posttranslational modification]
1266844005015	intermolecular recognition site; other site
1266844005016	dimerization interface [polypeptide binding]; other site
1266844005017	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1266844005018	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1266844005019	putative ligand binding site [chemical binding]; other site
1266844005020	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1266844005021	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1266844005022	TM-ABC transporter signature motif; other site
1266844005023	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1266844005024	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1266844005025	TM-ABC transporter signature motif; other site
1266844005026	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1266844005027	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1266844005028	Walker A/P-loop; other site
1266844005029	ATP binding site [chemical binding]; other site
1266844005030	Q-loop/lid; other site
1266844005031	ABC transporter signature motif; other site
1266844005032	Walker B; other site
1266844005033	D-loop; other site
1266844005034	H-loop/switch region; other site
1266844005035	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1266844005036	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1266844005037	Walker A/P-loop; other site
1266844005038	ATP binding site [chemical binding]; other site
1266844005039	Q-loop/lid; other site
1266844005040	ABC transporter signature motif; other site
1266844005041	Walker B; other site
1266844005042	D-loop; other site
1266844005043	H-loop/switch region; other site
1266844005044	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1266844005045	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1266844005046	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1266844005047	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1266844005048	DNA binding residues [nucleotide binding]
1266844005049	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1266844005050	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1266844005051	potential catalytic triad [active]
1266844005052	conserved cys residue [active]
1266844005053	atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229
1266844005054	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1266844005055	putative NAD(P) binding site [chemical binding]; other site
1266844005056	putative active site [active]
1266844005057	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266844005058	active site
1266844005059	Int/Topo IB signature motif; other site
1266844005060	DNA binding site [nucleotide binding]
1266844005061	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
1266844005062	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1266844005063	active site
1266844005064	NTP binding site [chemical binding]; other site
1266844005065	metal binding triad [ion binding]; metal-binding site
1266844005066	antibiotic binding site [chemical binding]; other site
1266844005067	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951
1266844005068	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
1266844005069	active site
1266844005070	NTP binding site [chemical binding]; other site
1266844005071	metal binding triad [ion binding]; metal-binding site
1266844005072	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1266844005073	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1266844005074	active site
1266844005075	Int/Topo IB signature motif; other site
1266844005076	catalytic residues [active]
1266844005077	DNA binding site [nucleotide binding]
1266844005078	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1266844005079	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844005080	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
1266844005081	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266844005082	active site
1266844005083	Int/Topo IB signature motif; other site
1266844005084	DNA binding site [nucleotide binding]
1266844005085	Protein of unknown function DUF45; Region: DUF45; pfam01863
1266844005086	hypothetical protein; Provisional; Region: PRK05170
1266844005087	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1266844005088	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1266844005089	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844005090	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1266844005091	Walker A/P-loop; other site
1266844005092	ATP binding site [chemical binding]; other site
1266844005093	Q-loop/lid; other site
1266844005094	ABC transporter signature motif; other site
1266844005095	Walker B; other site
1266844005096	D-loop; other site
1266844005097	H-loop/switch region; other site
1266844005098	TOBE domain; Region: TOBE_2; pfam08402
1266844005099	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
1266844005100	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1266844005101	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1266844005102	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1266844005103	multidrug resistance protein MdtN; Provisional; Region: PRK10476
1266844005104	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1266844005105	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844005106	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1266844005107	hopanoid-associated phosphorylase; Region: HpnG; TIGR03468
1266844005108	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
1266844005109	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
1266844005110	Active site cavity [active]
1266844005111	catalytic acid [active]
1266844005112	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
1266844005113	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1266844005114	active site lid residues [active]
1266844005115	substrate binding pocket [chemical binding]; other site
1266844005116	catalytic residues [active]
1266844005117	substrate-Mg2+ binding site; other site
1266844005118	aspartate-rich region 1; other site
1266844005119	aspartate-rich region 2; other site
1266844005120	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1266844005121	active site lid residues [active]
1266844005122	substrate binding pocket [chemical binding]; other site
1266844005123	catalytic residues [active]
1266844005124	substrate-Mg2+ binding site; other site
1266844005125	aspartate-rich region 1; other site
1266844005126	aspartate-rich region 2; other site
1266844005127	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
1266844005128	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1266844005129	active site
1266844005130	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1266844005131	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1266844005132	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
1266844005133	putative NADP binding site [chemical binding]; other site
1266844005134	putative substrate binding site [chemical binding]; other site
1266844005135	active site
1266844005136	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
1266844005137	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
1266844005138	prephenate dehydrogenase; Validated; Region: PRK08507
1266844005139	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1266844005140	TPR motif; other site
1266844005141	TPR repeat; Region: TPR_11; pfam13414
1266844005142	binding surface
1266844005143	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844005144	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1266844005145	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1266844005146	dimerization interface [polypeptide binding]; other site
1266844005147	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1266844005148	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1266844005149	dimer interface [polypeptide binding]; other site
1266844005150	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1266844005151	catalytic triad [active]
1266844005152	peroxidatic and resolving cysteines [active]
1266844005153	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1266844005154	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
1266844005155	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1266844005156	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1266844005157	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1266844005158	putative active site [active]
1266844005159	metal binding site [ion binding]; metal-binding site
1266844005160	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1266844005161	dimer interface [polypeptide binding]; other site
1266844005162	substrate binding site [chemical binding]; other site
1266844005163	metal binding sites [ion binding]; metal-binding site
1266844005164	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1266844005165	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844005166	Walker A/P-loop; other site
1266844005167	ATP binding site [chemical binding]; other site
1266844005168	Q-loop/lid; other site
1266844005169	ABC transporter signature motif; other site
1266844005170	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266844005171	ABC transporter; Region: ABC_tran_2; pfam12848
1266844005172	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1266844005173	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1266844005174	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1266844005175	Coenzyme A binding pocket [chemical binding]; other site
1266844005176	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1266844005177	VacJ like lipoprotein; Region: VacJ; cl01073
1266844005178	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1266844005179	putative metal binding site [ion binding]; other site
1266844005180	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
1266844005181	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1266844005182	HSP70 interaction site [polypeptide binding]; other site
1266844005183	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
1266844005184	epoxyqueuosine reductase; Region: TIGR00276
1266844005185	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1266844005186	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1266844005187	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1266844005188	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1266844005189	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1266844005190	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1266844005191	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
1266844005192	FAD binding site [chemical binding]; other site
1266844005193	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
1266844005194	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1266844005195	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1266844005196	homodimer interface [polypeptide binding]; other site
1266844005197	NADP binding site [chemical binding]; other site
1266844005198	substrate binding site [chemical binding]; other site
1266844005199	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1266844005200	Protein of unknown function, DUF482; Region: DUF482; pfam04339
1266844005201	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1266844005202	homotrimer interaction site [polypeptide binding]; other site
1266844005203	putative active site [active]
1266844005204	TSCPD domain; Region: TSCPD; pfam12637
1266844005205	NADH dehydrogenase; Validated; Region: PRK08183
1266844005206	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1266844005207	mce related protein; Region: MCE; pfam02470
1266844005208	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; cl01970
1266844005209	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266844005210	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
1266844005211	active site
1266844005212	motif I; other site
1266844005213	motif II; other site
1266844005214	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1266844005215	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1266844005216	active site
1266844005217	homotetramer interface [polypeptide binding]; other site
1266844005218	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
1266844005219	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1266844005220	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1266844005221	Probable Catalytic site; other site
1266844005222	metal-binding site
1266844005223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844005224	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1266844005225	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
1266844005226	nudix motif; other site
1266844005227	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266844005228	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266844005229	active site
1266844005230	catalytic tetrad [active]
1266844005231	Helix-turn-helix domain; Region: HTH_17; pfam12728
1266844005232	excinuclease ABC subunit B; Provisional; Region: PRK05298
1266844005233	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266844005234	ATP binding site [chemical binding]; other site
1266844005235	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844005236	nucleotide binding region [chemical binding]; other site
1266844005237	ATP-binding site [chemical binding]; other site
1266844005238	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1266844005239	UvrB/uvrC motif; Region: UVR; pfam02151
1266844005240	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1266844005241	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1266844005242	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1266844005243	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1266844005244	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1266844005245	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1266844005246	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1266844005247	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266844005248	active site
1266844005249	motif I; other site
1266844005250	motif II; other site
1266844005251	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1266844005252	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1266844005253	active site
1266844005254	L-asparagine permease; Provisional; Region: PRK15049
1266844005255	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1266844005256	active site
1266844005257	DNA polymerase IV; Validated; Region: PRK02406
1266844005258	DNA binding site [nucleotide binding]
1266844005259	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
1266844005260	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1266844005261	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1266844005262	quinone interaction residues [chemical binding]; other site
1266844005263	active site
1266844005264	catalytic residues [active]
1266844005265	FMN binding site [chemical binding]; other site
1266844005266	substrate binding site [chemical binding]; other site
1266844005267	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
1266844005268	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266844005269	active site
1266844005270	motif I; other site
1266844005271	motif II; other site
1266844005272	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1266844005273	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1266844005274	nudix motif; other site
1266844005275	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1266844005276	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1266844005277	putative active site [active]
1266844005278	metal binding site [ion binding]; metal-binding site
1266844005279	homodimer binding site [polypeptide binding]; other site
1266844005280	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1266844005281	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1266844005282	Cell division protein ZapA; Region: ZapA; cl01146
1266844005283	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
1266844005284	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1266844005285	putative active site; other site
1266844005286	catalytic residue [active]
1266844005287	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1266844005288	thiamine phosphate binding site [chemical binding]; other site
1266844005289	active site
1266844005290	pyrophosphate binding site [ion binding]; other site
1266844005291	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
1266844005292	Fasciclin domain; Region: Fasciclin; cl02663
1266844005293	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1266844005294	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
1266844005295	motif 1; other site
1266844005296	dimer interface [polypeptide binding]; other site
1266844005297	active site
1266844005298	motif 2; other site
1266844005299	motif 3; other site
1266844005300	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1266844005301	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844005302	FeS/SAM binding site; other site
1266844005303	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
1266844005304	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1266844005305	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1266844005306	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1266844005307	active site
1266844005308	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1266844005309	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1266844005310	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1266844005311	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
1266844005312	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844005313	Walker A motif; other site
1266844005314	ATP binding site [chemical binding]; other site
1266844005315	Walker B motif; other site
1266844005316	arginine finger; other site
1266844005317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844005318	Walker A motif; other site
1266844005319	ATP binding site [chemical binding]; other site
1266844005320	Walker B motif; other site
1266844005321	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1266844005322	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
1266844005323	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1266844005324	Putative transcriptional regulator [Transcription]; Region: COG1678
1266844005325	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1266844005326	Shikimate kinase; Region: SKI; pfam01202
1266844005327	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
1266844005328	homotrimer interaction site [polypeptide binding]; other site
1266844005329	putative active site [active]
1266844005330	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
1266844005331	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
1266844005332	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266844005333	HAMP domain; Region: HAMP; pfam00672
1266844005334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266844005335	dimer interface [polypeptide binding]; other site
1266844005336	phosphorylation site [posttranslational modification]
1266844005337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844005338	ATP binding site [chemical binding]; other site
1266844005339	Mg2+ binding site [ion binding]; other site
1266844005340	G-X-G motif; other site
1266844005341	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266844005342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844005343	active site
1266844005344	phosphorylation site [posttranslational modification]
1266844005345	intermolecular recognition site; other site
1266844005346	dimerization interface [polypeptide binding]; other site
1266844005347	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266844005348	DNA binding site [nucleotide binding]
1266844005349	GrpE; Region: GrpE; pfam01025
1266844005350	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1266844005351	dimer interface [polypeptide binding]; other site
1266844005352	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1266844005353	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1266844005354	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
1266844005355	nucleotide binding site [chemical binding]; other site
1266844005356	NEF interaction site [polypeptide binding]; other site
1266844005357	SBD interface [polypeptide binding]; other site
1266844005358	chaperone protein DnaJ; Provisional; Region: PRK10767
1266844005359	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1266844005360	HSP70 interaction site [polypeptide binding]; other site
1266844005361	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1266844005362	Zn binding sites [ion binding]; other site
1266844005363	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1266844005364	dimer interface [polypeptide binding]; other site
1266844005365	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1266844005366	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1266844005367	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1266844005368	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1266844005369	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1266844005370	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1266844005371	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1266844005372	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1266844005373	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1266844005374	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1266844005375	purine monophosphate binding site [chemical binding]; other site
1266844005376	dimer interface [polypeptide binding]; other site
1266844005377	putative catalytic residues [active]
1266844005378	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1266844005379	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1266844005380	EamA-like transporter family; Region: EamA; pfam00892
1266844005381	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1266844005382	DALR anticodon binding domain; Region: DALR_1; pfam05746
1266844005383	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1266844005384	dimer interface [polypeptide binding]; other site
1266844005385	motif 1; other site
1266844005386	active site
1266844005387	motif 2; other site
1266844005388	motif 3; other site
1266844005389	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
1266844005390	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1266844005391	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1266844005392	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1266844005393	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1266844005394	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844005395	non-specific DNA binding site [nucleotide binding]; other site
1266844005396	salt bridge; other site
1266844005397	sequence-specific DNA binding site [nucleotide binding]; other site
1266844005398	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
1266844005399	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1266844005400	putative active site [active]
1266844005401	catalytic triad [active]
1266844005402	putative dimer interface [polypeptide binding]; other site
1266844005403	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1266844005404	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1266844005405	metal binding site 2 [ion binding]; metal-binding site
1266844005406	putative DNA binding helix; other site
1266844005407	metal binding site 1 [ion binding]; metal-binding site
1266844005408	dimer interface [polypeptide binding]; other site
1266844005409	structural Zn2+ binding site [ion binding]; other site
1266844005410	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1266844005411	CPxP  motif; other site
1266844005412	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1266844005413	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1266844005414	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1266844005415	RNA binding site [nucleotide binding]; other site
1266844005416	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1266844005417	multimer interface [polypeptide binding]; other site
1266844005418	Walker A motif; other site
1266844005419	ATP binding site [chemical binding]; other site
1266844005420	Walker B motif; other site
1266844005421	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
1266844005422	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1266844005423	oligomer interface [polypeptide binding]; other site
1266844005424	Cl binding site [ion binding]; other site
1266844005425	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1266844005426	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1266844005427	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844005428	catalytic residue [active]
1266844005429	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1266844005430	substrate binding site [chemical binding]; other site
1266844005431	active site
1266844005432	catalytic residues [active]
1266844005433	heterodimer interface [polypeptide binding]; other site
1266844005434	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
1266844005435	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1266844005436	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1266844005437	Walker A motif; other site
1266844005438	ATP binding site [chemical binding]; other site
1266844005439	Walker B motif; other site
1266844005440	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
1266844005441	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1266844005442	dimer interface [polypeptide binding]; other site
1266844005443	motif 1; other site
1266844005444	active site
1266844005445	motif 2; other site
1266844005446	motif 3; other site
1266844005447	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1266844005448	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1266844005449	GDP-binding site [chemical binding]; other site
1266844005450	ACT binding site; other site
1266844005451	IMP binding site; other site
1266844005452	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
1266844005453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844005454	active site
1266844005455	phosphorylation site [posttranslational modification]
1266844005456	intermolecular recognition site; other site
1266844005457	dimerization interface [polypeptide binding]; other site
1266844005458	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266844005459	DNA binding site [nucleotide binding]
1266844005460	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1266844005461	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266844005462	dimer interface [polypeptide binding]; other site
1266844005463	phosphorylation site [posttranslational modification]
1266844005464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844005465	ATP binding site [chemical binding]; other site
1266844005466	Mg2+ binding site [ion binding]; other site
1266844005467	G-X-G motif; other site
1266844005468	PBP superfamily domain; Region: PBP_like_2; cl17296
1266844005469	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
1266844005470	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
1266844005471	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1266844005472	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1266844005473	catalytic core [active]
1266844005474	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1266844005475	Domain of unknown function DUF21; Region: DUF21; pfam01595
1266844005476	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1266844005477	Transporter associated domain; Region: CorC_HlyC; smart01091
1266844005478	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1266844005479	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1266844005480	NADP binding site [chemical binding]; other site
1266844005481	dimer interface [polypeptide binding]; other site
1266844005482	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1266844005483	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
1266844005484	putative active site [active]
1266844005485	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266844005486	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1266844005487	Walker A/P-loop; other site
1266844005488	ATP binding site [chemical binding]; other site
1266844005489	Q-loop/lid; other site
1266844005490	ABC transporter signature motif; other site
1266844005491	Walker B; other site
1266844005492	D-loop; other site
1266844005493	H-loop/switch region; other site
1266844005494	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1266844005495	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1266844005496	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844005497	Hint domain; Region: Hint_2; pfam13403
1266844005498	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1266844005499	classical (c) SDRs; Region: SDR_c; cd05233
1266844005500	NAD(P) binding site [chemical binding]; other site
1266844005501	active site
1266844005502	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
1266844005503	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1266844005504	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1266844005505	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1266844005506	homodimer interface [polypeptide binding]; other site
1266844005507	metal binding site [ion binding]; metal-binding site
1266844005508	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1266844005509	homodimer interface [polypeptide binding]; other site
1266844005510	active site
1266844005511	putative chemical substrate binding site [chemical binding]; other site
1266844005512	metal binding site [ion binding]; metal-binding site
1266844005513	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
1266844005514	heat shock protein 90; Provisional; Region: PRK05218
1266844005515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844005516	ATP binding site [chemical binding]; other site
1266844005517	Mg2+ binding site [ion binding]; other site
1266844005518	G-X-G motif; other site
1266844005519	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
1266844005520	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
1266844005521	CotH protein; Region: CotH; pfam08757
1266844005522	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
1266844005523	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
1266844005524	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1266844005525	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1266844005526	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1266844005527	active site
1266844005528	substrate binding site [chemical binding]; other site
1266844005529	Mg2+ binding site [ion binding]; other site
1266844005530	hypothetical protein; Provisional; Region: PRK09272
1266844005531	hypothetical protein; Provisional; Region: PRK10316
1266844005532	YfdX protein; Region: YfdX; pfam10938
1266844005533	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1266844005534	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844005535	sequence-specific DNA binding site [nucleotide binding]; other site
1266844005536	salt bridge; other site
1266844005537	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1266844005538	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1266844005539	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1266844005540	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1266844005541	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1266844005542	methylcitrate synthase; Provisional; Region: PRK12351
1266844005543	oxalacetate binding site [chemical binding]; other site
1266844005544	citrylCoA binding site [chemical binding]; other site
1266844005545	coenzyme A binding site [chemical binding]; other site
1266844005546	catalytic triad [active]
1266844005547	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1266844005548	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1266844005549	tetramer interface [polypeptide binding]; other site
1266844005550	active site
1266844005551	Mg2+/Mn2+ binding site [ion binding]; other site
1266844005552	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1266844005553	acetyl-CoA synthetase; Provisional; Region: PRK00174
1266844005554	acyl-activating enzyme (AAE) consensus motif; other site
1266844005555	AMP binding site [chemical binding]; other site
1266844005556	active site
1266844005557	CoA binding site [chemical binding]; other site
1266844005558	putative sialic acid transporter; Region: 2A0112; TIGR00891
1266844005559	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844005560	putative substrate translocation pore; other site
1266844005561	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
1266844005562	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1266844005563	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1266844005564	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
1266844005565	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1266844005566	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1266844005567	dimer interface [polypeptide binding]; other site
1266844005568	anticodon binding site; other site
1266844005569	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1266844005570	homodimer interface [polypeptide binding]; other site
1266844005571	motif 1; other site
1266844005572	active site
1266844005573	motif 2; other site
1266844005574	GAD domain; Region: GAD; pfam02938
1266844005575	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1266844005576	active site
1266844005577	motif 3; other site
1266844005578	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1266844005579	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1266844005580	tetramer interface [polypeptide binding]; other site
1266844005581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844005582	catalytic residue [active]
1266844005583	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1266844005584	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1266844005585	5S rRNA interface [nucleotide binding]; other site
1266844005586	CTC domain interface [polypeptide binding]; other site
1266844005587	L16 interface [polypeptide binding]; other site
1266844005588	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1266844005589	putative active site [active]
1266844005590	catalytic residue [active]
1266844005591	GTP-binding protein YchF; Reviewed; Region: PRK09601
1266844005592	YchF GTPase; Region: YchF; cd01900
1266844005593	G1 box; other site
1266844005594	GTP/Mg2+ binding site [chemical binding]; other site
1266844005595	Switch I region; other site
1266844005596	G2 box; other site
1266844005597	Switch II region; other site
1266844005598	G3 box; other site
1266844005599	G4 box; other site
1266844005600	G5 box; other site
1266844005601	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1266844005602	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1266844005603	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1266844005604	putative catalytic cysteine [active]
1266844005605	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1266844005606	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1266844005607	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1266844005608	Rhodanese-like domain; Region: Rhodanese; pfam00581
1266844005609	active site residue [active]
1266844005610	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1266844005611	active site residue [active]
1266844005612	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844005613	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844005614	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1266844005615	putative dimerization interface [polypeptide binding]; other site
1266844005616	putative substrate binding pocket [chemical binding]; other site
1266844005617	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1266844005618	acetolactate synthase; Reviewed; Region: PRK08617
1266844005619	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1266844005620	PYR/PP interface [polypeptide binding]; other site
1266844005621	dimer interface [polypeptide binding]; other site
1266844005622	TPP binding site [chemical binding]; other site
1266844005623	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1266844005624	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1266844005625	TPP-binding site [chemical binding]; other site
1266844005626	benzoylformate decarboxylase; Reviewed; Region: PRK07092
1266844005627	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1266844005628	PYR/PP interface [polypeptide binding]; other site
1266844005629	dimer interface [polypeptide binding]; other site
1266844005630	TPP binding site [chemical binding]; other site
1266844005631	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1266844005632	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
1266844005633	TPP-binding site [chemical binding]; other site
1266844005634	dimer interface [polypeptide binding]; other site
1266844005635	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1266844005636	Cysteine-rich domain; Region: CCG; pfam02754
1266844005637	Cysteine-rich domain; Region: CCG; pfam02754
1266844005638	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1266844005639	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1266844005640	4Fe-4S binding domain; Region: Fer4; pfam00037
1266844005641	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1266844005642	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1266844005643	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1266844005644	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1266844005645	hinge; other site
1266844005646	active site
1266844005647	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1266844005648	trimer interface [polypeptide binding]; other site
1266844005649	active site
1266844005650	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1266844005651	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
1266844005652	putative active site [active]
1266844005653	YdjC motif; other site
1266844005654	Mg binding site [ion binding]; other site
1266844005655	putative homodimer interface [polypeptide binding]; other site
1266844005656	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
1266844005657	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1266844005658	B12 binding site [chemical binding]; other site
1266844005659	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844005660	FeS/SAM binding site; other site
1266844005661	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
1266844005662	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
1266844005663	ligand binding site; other site
1266844005664	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
1266844005665	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1266844005666	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1266844005667	TPP-binding site; other site
1266844005668	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1266844005669	PYR/PP interface [polypeptide binding]; other site
1266844005670	dimer interface [polypeptide binding]; other site
1266844005671	TPP binding site [chemical binding]; other site
1266844005672	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1266844005673	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
1266844005674	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844005675	FeS/SAM binding site; other site
1266844005676	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1266844005677	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
1266844005678	gliding motility-associated protein GldE; Region: GldE; TIGR03520
1266844005679	Domain of unknown function DUF21; Region: DUF21; pfam01595
1266844005680	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1266844005681	Transporter associated domain; Region: CorC_HlyC; smart01091
1266844005682	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1266844005683	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1266844005684	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1266844005685	catalytic residue [active]
1266844005686	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1266844005687	Fe-S cluster binding site [ion binding]; other site
1266844005688	active site
1266844005689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1266844005690	binding surface
1266844005691	TPR motif; other site
1266844005692	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1266844005693	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1266844005694	TPR motif; other site
1266844005695	TPR repeat; Region: TPR_11; pfam13414
1266844005696	binding surface
1266844005697	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
1266844005698	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844005699	NAD(P) binding site [chemical binding]; other site
1266844005700	active site
1266844005701	Predicted membrane protein [Function unknown]; Region: COG1238
1266844005702	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1266844005703	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1266844005704	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1266844005705	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1266844005706	Walker A/P-loop; other site
1266844005707	ATP binding site [chemical binding]; other site
1266844005708	Q-loop/lid; other site
1266844005709	ABC transporter signature motif; other site
1266844005710	Walker B; other site
1266844005711	D-loop; other site
1266844005712	H-loop/switch region; other site
1266844005713	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1266844005714	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1266844005715	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1266844005716	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00934
1266844005717	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1266844005718	active site
1266844005719	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1266844005720	catalytic core [active]
1266844005721	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
1266844005722	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844005723	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844005724	short chain dehydrogenase; Provisional; Region: PRK12744
1266844005725	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844005726	NAD(P) binding site [chemical binding]; other site
1266844005727	active site
1266844005728	transcriptional regulator; Provisional; Region: PRK10632
1266844005729	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844005730	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1266844005731	putative effector binding pocket; other site
1266844005732	putative dimerization interface [polypeptide binding]; other site
1266844005733	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1266844005734	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1266844005735	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1266844005736	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844005737	N-terminal plug; other site
1266844005738	ligand-binding site [chemical binding]; other site
1266844005739	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1266844005740	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1266844005741	intersubunit interface [polypeptide binding]; other site
1266844005742	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1266844005743	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1266844005744	putative PBP binding regions; other site
1266844005745	ABC-ATPase subunit  interface; other site
1266844005746	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1266844005747	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1266844005748	Walker A/P-loop; other site
1266844005749	ATP binding site [chemical binding]; other site
1266844005750	Q-loop/lid; other site
1266844005751	ABC transporter signature motif; other site
1266844005752	Walker B; other site
1266844005753	D-loop; other site
1266844005754	H-loop/switch region; other site
1266844005755	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
1266844005756	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
1266844005757	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
1266844005758	active site
1266844005759	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1266844005760	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1266844005761	putative active site [active]
1266844005762	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
1266844005763	Na binding site [ion binding]; other site
1266844005764	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1266844005765	Hint domain; Region: Hint_2; pfam13403
1266844005766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1266844005767	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1266844005768	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1266844005769	DNA binding residues [nucleotide binding]
1266844005770	dimerization interface [polypeptide binding]; other site
1266844005771	Hint domain; Region: Hint_2; pfam13403
1266844005772	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1266844005773	DNA photolyase; Region: DNA_photolyase; pfam00875
1266844005774	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
1266844005775	SelR domain; Region: SelR; pfam01641
1266844005776	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
1266844005777	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1266844005778	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1266844005779	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
1266844005780	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844005781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844005782	homodimer interface [polypeptide binding]; other site
1266844005783	catalytic residue [active]
1266844005784	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
1266844005785	Hint domain; Region: Hint_2; pfam13403
1266844005786	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1266844005787	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1266844005788	dimerization interface [polypeptide binding]; other site
1266844005789	DPS ferroxidase diiron center [ion binding]; other site
1266844005790	ion pore; other site
1266844005791	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1266844005792	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1266844005793	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1266844005794	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
1266844005795	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1266844005796	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1266844005797	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844005798	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844005799	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1266844005800	dimerization interface [polypeptide binding]; other site
1266844005801	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1266844005802	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
1266844005803	Methylamine utilisation protein MauE; Region: MauE; pfam07291
1266844005804	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1266844005805	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1266844005806	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
1266844005807	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
1266844005808	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1266844005809	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266844005810	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266844005811	active site
1266844005812	catalytic tetrad [active]
1266844005813	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1266844005814	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1266844005815	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1266844005816	dimerization interface [polypeptide binding]; other site
1266844005817	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
1266844005818	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1266844005819	NAD binding site [chemical binding]; other site
1266844005820	catalytic residues [active]
1266844005821	substrate binding site [chemical binding]; other site
1266844005822	Cytochrome c; Region: Cytochrom_C; cl11414
1266844005823	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1266844005824	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1266844005825	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1266844005826	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1266844005827	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1266844005828	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1266844005829	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1266844005830	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1266844005831	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1266844005832	catalytic loop [active]
1266844005833	iron binding site [ion binding]; other site
1266844005834	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1266844005835	Protein of unknown function (DUF563); Region: DUF563; pfam04577
1266844005836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844005837	S-adenosylmethionine binding site [chemical binding]; other site
1266844005838	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
1266844005839	Hint domain; Region: Hint_2; pfam13403
1266844005840	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844005841	putative substrate translocation pore; other site
1266844005842	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1266844005843	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
1266844005844	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266844005845	YGGT family; Region: YGGT; pfam02325
1266844005846	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1266844005847	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1266844005848	CHRD domain; Region: CHRD; pfam07452
1266844005849	Predicted membrane protein [Function unknown]; Region: COG3650
1266844005850	META domain; Region: META; pfam03724
1266844005851	Hint domain; Region: Hint_2; pfam13403
1266844005852	T5orf172 domain; Region: T5orf172; pfam10544
1266844005853	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
1266844005854	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1266844005855	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1266844005856	N-terminal plug; other site
1266844005857	ligand-binding site [chemical binding]; other site
1266844005858	Cytochrome c; Region: Cytochrom_C; pfam00034
1266844005859	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1266844005860	FAD dependent oxidoreductase; Region: DAO; pfam01266
1266844005861	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844005862	NmrA-like family; Region: NmrA; pfam05368
1266844005863	NAD(P) binding site [chemical binding]; other site
1266844005864	active site
1266844005865	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1266844005866	Hint domain; Region: Hint_2; pfam13403
1266844005867	Hint domain; Region: Hint_2; pfam13403
1266844005868	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1266844005869	Hint domain; Region: Hint_2; pfam13403
1266844005870	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844005871	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1266844005872	non-specific DNA binding site [nucleotide binding]; other site
1266844005873	salt bridge; other site
1266844005874	sequence-specific DNA binding site [nucleotide binding]; other site
1266844005875	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1266844005876	Catalytic site [active]
1266844005877	Phage terminase, small subunit; Region: Terminase_4; cl01525
1266844005878	Hint domain; Region: Hint_2; pfam13403
1266844005879	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1266844005880	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1266844005881	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1266844005882	DNA-binding interface [nucleotide binding]; DNA binding site
1266844005883	Hint domain; Region: Hint_2; pfam13403
1266844005884	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1266844005885	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1266844005886	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844005887	FeS/SAM binding site; other site
1266844005888	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1266844005889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
1266844005890	Terminase-like family; Region: Terminase_6; pfam03237
1266844005891	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
1266844005892	hypothetical protein; Validated; Region: PRK01415
1266844005893	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1266844005894	active site residue [active]
1266844005895	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
1266844005896	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
1266844005897	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
1266844005898	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
1266844005899	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
1266844005900	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
1266844005901	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
1266844005902	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
1266844005903	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
1266844005904	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1266844005905	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844005906	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844005907	serine/threonine protein kinase; Provisional; Region: PRK11768
1266844005908	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1266844005909	Phosphotransferase enzyme family; Region: APH; pfam01636
1266844005910	substrate binding site [chemical binding]; other site
1266844005911	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1266844005912	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
1266844005913	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1266844005914	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1266844005915	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1266844005916	putative active site [active]
1266844005917	putative substrate binding site [chemical binding]; other site
1266844005918	putative cosubstrate binding site; other site
1266844005919	catalytic site [active]
1266844005920	Uncharacterized conserved protein [Function unknown]; Region: COG3189
1266844005921	Predicted transcriptional regulator [Transcription]; Region: COG1959
1266844005922	Transcriptional regulator; Region: Rrf2; cl17282
1266844005923	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844005924	malonic semialdehyde reductase; Provisional; Region: PRK10538
1266844005925	NAD(P) binding site [chemical binding]; other site
1266844005926	active site
1266844005927	CrcB-like protein; Region: CRCB; cl09114
1266844005928	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1266844005929	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266844005930	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1266844005931	dinuclear metal binding motif [ion binding]; other site
1266844005932	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1266844005933	Hint domain; Region: Hint_2; pfam13403
1266844005934	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1266844005935	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1266844005936	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1266844005937	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1266844005938	active site
1266844005939	Zn binding site [ion binding]; other site
1266844005940	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1266844005941	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1266844005942	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844005943	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844005944	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1266844005945	Coenzyme A transferase; Region: CoA_trans; smart00882
1266844005946	Coenzyme A transferase; Region: CoA_trans; cl17247
1266844005947	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
1266844005948	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
1266844005949	MOFRL family; Region: MOFRL; pfam05161
1266844005950	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1266844005951	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1266844005952	active site
1266844005953	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
1266844005954	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844005955	NAD(P) binding site [chemical binding]; other site
1266844005956	active site
1266844005957	Protein of unknown function (DUF993); Region: DUF993; pfam06187
1266844005958	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1266844005959	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1266844005960	DNA interaction; other site
1266844005961	Metal-binding active site; metal-binding site
1266844005962	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1266844005963	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1266844005964	Ligand binding site [chemical binding]; other site
1266844005965	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1266844005966	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1266844005967	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1266844005968	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1266844005969	Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118
1266844005970	NAD(P) binding site [chemical binding]; other site
1266844005971	catalytic residues [active]
1266844005972	choline dehydrogenase; Validated; Region: PRK02106
1266844005973	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1266844005974	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1266844005975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844005976	putative substrate translocation pore; other site
1266844005977	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1266844005978	Hint domain; Region: Hint_2; pfam13403
1266844005979	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1266844005980	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1266844005981	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1266844005982	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1266844005983	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1266844005984	tetramer interface [polypeptide binding]; other site
1266844005985	TPP-binding site [chemical binding]; other site
1266844005986	heterodimer interface [polypeptide binding]; other site
1266844005987	phosphorylation loop region [posttranslational modification]
1266844005988	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1266844005989	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1266844005990	alpha subunit interface [polypeptide binding]; other site
1266844005991	TPP binding site [chemical binding]; other site
1266844005992	heterodimer interface [polypeptide binding]; other site
1266844005993	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1266844005994	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
1266844005995	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1266844005996	E3 interaction surface; other site
1266844005997	lipoyl attachment site [posttranslational modification]; other site
1266844005998	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1266844005999	catalytic site [active]
1266844006000	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1266844006001	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1266844006002	putative dimer interface [polypeptide binding]; other site
1266844006003	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1266844006004	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1266844006005	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1266844006006	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1266844006007	structural tetrad; other site
1266844006008	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1266844006009	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1266844006010	P-loop, Walker A motif; other site
1266844006011	Base recognition motif; other site
1266844006012	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1266844006013	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1266844006014	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
1266844006015	putative ion selectivity filter; other site
1266844006016	putative pore gating glutamate residue; other site
1266844006017	putative H+/Cl- coupling transport residue; other site
1266844006018	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1266844006019	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1266844006020	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1266844006021	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1266844006022	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1266844006023	acyl-CoA esterase; Provisional; Region: PRK10673
1266844006024	PGAP1-like protein; Region: PGAP1; pfam07819
1266844006025	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1266844006026	Ligand Binding Site [chemical binding]; other site
1266844006027	OPT oligopeptide transporter protein; Region: OPT; cl14607
1266844006028	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
1266844006029	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
1266844006030	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
1266844006031	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1266844006032	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1266844006033	ATP binding site [chemical binding]; other site
1266844006034	substrate interface [chemical binding]; other site
1266844006035	Bacterial SH3 domain; Region: SH3_4; pfam06347
1266844006036	Bacterial SH3 domain; Region: SH3_4; pfam06347
1266844006037	pyruvate kinase; Provisional; Region: PRK06247
1266844006038	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1266844006039	domain interfaces; other site
1266844006040	active site
1266844006041	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1266844006042	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844006043	putative substrate translocation pore; other site
1266844006044	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1266844006045	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1266844006046	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1266844006047	G1 box; other site
1266844006048	putative GEF interaction site [polypeptide binding]; other site
1266844006049	GTP/Mg2+ binding site [chemical binding]; other site
1266844006050	Switch I region; other site
1266844006051	G2 box; other site
1266844006052	G3 box; other site
1266844006053	Switch II region; other site
1266844006054	G4 box; other site
1266844006055	G5 box; other site
1266844006056	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1266844006057	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1266844006058	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1266844006059	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1266844006060	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1266844006061	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1266844006062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1266844006063	isocitrate dehydrogenase; Validated; Region: PRK06451
1266844006064	isocitrate dehydrogenase; Validated; Region: PRK08299
1266844006065	hypothetical protein; Provisional; Region: PRK08912
1266844006066	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1266844006067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844006068	homodimer interface [polypeptide binding]; other site
1266844006069	catalytic residue [active]
1266844006070	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
1266844006071	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1266844006072	glutamine synthetase; Provisional; Region: glnA; PRK09469
1266844006073	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1266844006074	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1266844006075	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1266844006076	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1266844006077	Trp docking motif [polypeptide binding]; other site
1266844006078	putative active site [active]
1266844006079	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1266844006080	Predicted transcriptional regulator [Transcription]; Region: COG2932
1266844006081	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1266844006082	Catalytic site [active]
1266844006083	GTP-binding protein LepA; Provisional; Region: PRK05433
1266844006084	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1266844006085	G1 box; other site
1266844006086	putative GEF interaction site [polypeptide binding]; other site
1266844006087	GTP/Mg2+ binding site [chemical binding]; other site
1266844006088	Switch I region; other site
1266844006089	G2 box; other site
1266844006090	G3 box; other site
1266844006091	Switch II region; other site
1266844006092	G4 box; other site
1266844006093	G5 box; other site
1266844006094	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1266844006095	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1266844006096	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1266844006097	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1266844006098	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1266844006099	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1266844006100	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844006101	S-adenosylmethionine binding site [chemical binding]; other site
1266844006102	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1266844006103	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1266844006104	ATP binding site [chemical binding]; other site
1266844006105	Mg++ binding site [ion binding]; other site
1266844006106	motif III; other site
1266844006107	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844006108	nucleotide binding region [chemical binding]; other site
1266844006109	ATP-binding site [chemical binding]; other site
1266844006110	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1266844006111	putative catalytic site [active]
1266844006112	putative metal binding site [ion binding]; other site
1266844006113	putative phosphate binding site [ion binding]; other site
1266844006114	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1266844006115	active site clefts [active]
1266844006116	zinc binding site [ion binding]; other site
1266844006117	dimer interface [polypeptide binding]; other site
1266844006118	LabA_like proteins; Region: LabA; cd10911
1266844006119	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1266844006120	putative metal binding site [ion binding]; other site
1266844006121	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1266844006122	catalytic center binding site [active]
1266844006123	ATP binding site [chemical binding]; other site
1266844006124	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1266844006125	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1266844006126	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1266844006127	Zn2+ binding site [ion binding]; other site
1266844006128	Mg2+ binding site [ion binding]; other site
1266844006129	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1266844006130	synthetase active site [active]
1266844006131	NTP binding site [chemical binding]; other site
1266844006132	metal binding site [ion binding]; metal-binding site
1266844006133	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1266844006134	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1266844006135	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1266844006136	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1266844006137	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1266844006138	Catalytic site [active]
1266844006139	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1266844006140	ribonuclease III; Reviewed; Region: rnc; PRK00102
1266844006141	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1266844006142	dimerization interface [polypeptide binding]; other site
1266844006143	active site
1266844006144	metal binding site [ion binding]; metal-binding site
1266844006145	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1266844006146	GTPase Era; Reviewed; Region: era; PRK00089
1266844006147	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1266844006148	G1 box; other site
1266844006149	GTP/Mg2+ binding site [chemical binding]; other site
1266844006150	Switch I region; other site
1266844006151	G2 box; other site
1266844006152	Switch II region; other site
1266844006153	G3 box; other site
1266844006154	G4 box; other site
1266844006155	G5 box; other site
1266844006156	KH domain; Region: KH_2; pfam07650
1266844006157	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1266844006158	putative nucleotide binding site [chemical binding]; other site
1266844006159	uridine monophosphate binding site [chemical binding]; other site
1266844006160	homohexameric interface [polypeptide binding]; other site
1266844006161	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1266844006162	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1266844006163	hinge region; other site
1266844006164	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1266844006165	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1266844006166	catalytic residue [active]
1266844006167	putative FPP diphosphate  binding site; other site
1266844006168	putative FPP binding hydrophobic cleft; other site
1266844006169	dimer interface [polypeptide binding]; other site
1266844006170	putative IPP diphosphate binding site; other site
1266844006171	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1266844006172	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1266844006173	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1266844006174	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1266844006175	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1266844006176	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1266844006177	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1266844006178	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1266844006179	active site
1266844006180	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1266844006181	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1266844006182	putative substrate binding region [chemical binding]; other site
1266844006183	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1266844006184	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1266844006185	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1266844006186	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1266844006187	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1266844006188	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1266844006189	Surface antigen; Region: Bac_surface_Ag; pfam01103
1266844006190	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1266844006191	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
1266844006192	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1266844006193	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1266844006194	trimer interface [polypeptide binding]; other site
1266844006195	active site
1266844006196	UDP-GlcNAc binding site [chemical binding]; other site
1266844006197	lipid binding site [chemical binding]; lipid-binding site
1266844006198	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1266844006199	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1266844006200	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1266844006201	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1266844006202	putative trimer interface [polypeptide binding]; other site
1266844006203	putative CoA binding site [chemical binding]; other site
1266844006204	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
1266844006205	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1266844006206	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1266844006207	dimer interface [polypeptide binding]; other site
1266844006208	active site
1266844006209	metal binding site [ion binding]; metal-binding site
1266844006210	glutathione binding site [chemical binding]; other site
1266844006211	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1266844006212	Ribonuclease P; Region: Ribonuclease_P; pfam00825
1266844006213	membrane protein insertase; Provisional; Region: PRK01318
1266844006214	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1266844006215	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1266844006216	G1 box; other site
1266844006217	GTP/Mg2+ binding site [chemical binding]; other site
1266844006218	Switch I region; other site
1266844006219	G2 box; other site
1266844006220	G3 box; other site
1266844006221	Switch II region; other site
1266844006222	G4 box; other site
1266844006223	G5 box; other site
1266844006224	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1266844006225	homohexameric interface [polypeptide binding]; other site
1266844006226	feedback inhibition sensing region; other site
1266844006227	nucleotide binding site [chemical binding]; other site
1266844006228	N-acetyl-L-glutamate binding site [chemical binding]; other site
1266844006229	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1266844006230	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1266844006231	trimer interface [polypeptide binding]; other site
1266844006232	active site
1266844006233	substrate binding site [chemical binding]; other site
1266844006234	CoA binding site [chemical binding]; other site
1266844006235	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1266844006236	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1266844006237	metal binding site [ion binding]; metal-binding site
1266844006238	dimer interface [polypeptide binding]; other site
1266844006239	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1266844006240	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1266844006241	dimerization interface 3.5A [polypeptide binding]; other site
1266844006242	active site
1266844006243	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1266844006244	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1266844006245	putative active site [active]
1266844006246	substrate binding site [chemical binding]; other site
1266844006247	putative cosubstrate binding site; other site
1266844006248	catalytic site [active]
1266844006249	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1266844006250	substrate binding site [chemical binding]; other site
1266844006251	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1266844006252	active site
1266844006253	catalytic residues [active]
1266844006254	metal binding site [ion binding]; metal-binding site
1266844006255	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1266844006256	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1266844006257	putative dimer interface [polypeptide binding]; other site
1266844006258	Protein of unknown function (DUF1150); Region: DUF1150; cl11577
1266844006259	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1266844006260	30S subunit binding site; other site
1266844006261	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1266844006262	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1266844006263	MOSC domain; Region: MOSC; pfam03473
1266844006264	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1266844006265	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1266844006266	Walker A/P-loop; other site
1266844006267	ATP binding site [chemical binding]; other site
1266844006268	Q-loop/lid; other site
1266844006269	ABC transporter signature motif; other site
1266844006270	Walker B; other site
1266844006271	D-loop; other site
1266844006272	H-loop/switch region; other site
1266844006273	OstA-like protein; Region: OstA; cl00844
1266844006274	OstA-like protein; Region: OstA; cl00844
1266844006275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
1266844006276	KpsF/GutQ family protein; Region: kpsF; TIGR00393
1266844006277	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1266844006278	putative active site [active]
1266844006279	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1266844006280	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1266844006281	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1266844006282	catalytic site [active]
1266844006283	putative active site [active]
1266844006284	putative substrate binding site [chemical binding]; other site
1266844006285	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1266844006286	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1266844006287	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1266844006288	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1266844006289	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1266844006290	short chain dehydrogenase; Provisional; Region: PRK07024
1266844006291	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844006292	NAD(P) binding site [chemical binding]; other site
1266844006293	active site
1266844006294	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1266844006295	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1266844006296	catalytic site [active]
1266844006297	G-X2-G-X-G-K; other site
1266844006298	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1266844006299	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1266844006300	putative ribose interaction site [chemical binding]; other site
1266844006301	putative ADP binding site [chemical binding]; other site
1266844006302	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1266844006303	active site
1266844006304	nucleotide binding site [chemical binding]; other site
1266844006305	HIGH motif; other site
1266844006306	KMSKS motif; other site
1266844006307	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1266844006308	dimerization interface [polypeptide binding]; other site
1266844006309	putative active cleft [active]
1266844006310	replicative DNA helicase; Provisional; Region: PRK09165
1266844006311	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1266844006312	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1266844006313	Walker A motif; other site
1266844006314	ATP binding site [chemical binding]; other site
1266844006315	Walker B motif; other site
1266844006316	DNA binding loops [nucleotide binding]
1266844006317	Nuclease-related domain; Region: NERD; pfam08378
1266844006318	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
1266844006319	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1266844006320	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
1266844006321	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1266844006322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844006323	Walker A/P-loop; other site
1266844006324	ATP binding site [chemical binding]; other site
1266844006325	Q-loop/lid; other site
1266844006326	ABC transporter signature motif; other site
1266844006327	Walker B; other site
1266844006328	D-loop; other site
1266844006329	H-loop/switch region; other site
1266844006330	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1266844006331	Permease; Region: Permease; pfam02405
1266844006332	DNA repair protein RadA; Provisional; Region: PRK11823
1266844006333	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1266844006334	Walker A motif/ATP binding site; other site
1266844006335	ATP binding site [chemical binding]; other site
1266844006336	Walker B motif; other site
1266844006337	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1266844006338	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1266844006339	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1266844006340	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
1266844006341	Proline dehydrogenase; Region: Pro_dh; pfam01619
1266844006342	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1266844006343	Glutamate binding site [chemical binding]; other site
1266844006344	NAD binding site [chemical binding]; other site
1266844006345	catalytic residues [active]
1266844006346	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1266844006347	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1266844006348	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1266844006349	DNA-binding site [nucleotide binding]; DNA binding site
1266844006350	FCD domain; Region: FCD; pfam07729
1266844006351	Protein of unknown function (DUF2501); Region: DUF2501; cl08197
1266844006352	acetyl-CoA synthetase; Provisional; Region: PRK00174
1266844006353	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1266844006354	acyl-activating enzyme (AAE) consensus motif; other site
1266844006355	AMP binding site [chemical binding]; other site
1266844006356	active site
1266844006357	CoA binding site [chemical binding]; other site
1266844006358	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
1266844006359	FtsJ-like methyltransferase; Region: FtsJ; cl17430
1266844006360	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1266844006361	hypothetical protein; Validated; Region: PRK09039
1266844006362	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1266844006363	FAD binding domain; Region: FAD_binding_4; pfam01565
1266844006364	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1266844006365	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1266844006366	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1266844006367	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1266844006368	interface (dimer of trimers) [polypeptide binding]; other site
1266844006369	Substrate-binding/catalytic site; other site
1266844006370	Zn-binding sites [ion binding]; other site
1266844006371	DNA polymerase III subunit chi; Validated; Region: PRK05728
1266844006372	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1266844006373	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1266844006374	active site
1266844006375	catalytic tetrad [active]
1266844006376	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1266844006377	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1266844006378	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1266844006379	protein binding site [polypeptide binding]; other site
1266844006380	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
1266844006381	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266844006382	ATP binding site [chemical binding]; other site
1266844006383	putative Mg++ binding site [ion binding]; other site
1266844006384	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844006385	nucleotide binding region [chemical binding]; other site
1266844006386	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1266844006387	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1266844006388	dimerization interface [polypeptide binding]; other site
1266844006389	domain crossover interface; other site
1266844006390	redox-dependent activation switch; other site
1266844006391	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1266844006392	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1266844006393	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1266844006394	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
1266844006395	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1266844006396	inhibitor-cofactor binding pocket; inhibition site
1266844006397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844006398	catalytic residue [active]
1266844006399	RecX family; Region: RecX; pfam02631
1266844006400	CHAP domain; Region: CHAP; cl17642
1266844006401	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
1266844006402	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
1266844006403	intersubunit interface [polypeptide binding]; other site
1266844006404	active site
1266844006405	Zn2+ binding site [ion binding]; other site
1266844006406	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
1266844006407	Cupin domain; Region: Cupin_2; cl17218
1266844006408	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
1266844006409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1266844006410	motif II; other site
1266844006411	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1266844006412	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1266844006413	active site
1266844006414	Riboflavin kinase; Region: Flavokinase; smart00904
1266844006415	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1266844006416	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1266844006417	active site
1266844006418	HIGH motif; other site
1266844006419	nucleotide binding site [chemical binding]; other site
1266844006420	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1266844006421	active site
1266844006422	KMSKS motif; other site
1266844006423	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1266844006424	tRNA binding surface [nucleotide binding]; other site
1266844006425	anticodon binding site; other site
1266844006426	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1266844006427	lipoprotein signal peptidase; Provisional; Region: PRK14770
1266844006428	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
1266844006429	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1266844006430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844006431	ATP binding site [chemical binding]; other site
1266844006432	Mg2+ binding site [ion binding]; other site
1266844006433	G-X-G motif; other site
1266844006434	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1266844006435	ATP binding site [chemical binding]; other site
1266844006436	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1266844006437	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1266844006438	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1266844006439	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
1266844006440	EamA-like transporter family; Region: EamA; pfam00892
1266844006441	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1266844006442	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844006443	Mg2+ binding site [ion binding]; other site
1266844006444	G-X-G motif; other site
1266844006445	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1266844006446	anchoring element; other site
1266844006447	dimer interface [polypeptide binding]; other site
1266844006448	ATP binding site [chemical binding]; other site
1266844006449	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1266844006450	active site
1266844006451	putative metal-binding site [ion binding]; other site
1266844006452	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1266844006453	Rrf2 family protein; Region: rrf2_super; TIGR00738
1266844006454	Transcriptional regulator; Region: Rrf2; pfam02082
1266844006455	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1266844006456	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1266844006457	dimer interface [polypeptide binding]; other site
1266844006458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844006459	catalytic residue [active]
1266844006460	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1266844006461	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1266844006462	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1266844006463	ligand binding site [chemical binding]; other site
1266844006464	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
1266844006465	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1266844006466	C-terminal peptidase (prc); Region: prc; TIGR00225
1266844006467	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1266844006468	protein binding site [polypeptide binding]; other site
1266844006469	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1266844006470	Catalytic dyad [active]
1266844006471	Exoribonuclease R [Transcription]; Region: VacB; COG0557
1266844006472	RNB domain; Region: RNB; pfam00773
1266844006473	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1266844006474	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1266844006475	active site
1266844006476	interdomain interaction site; other site
1266844006477	putative metal-binding site [ion binding]; other site
1266844006478	nucleotide binding site [chemical binding]; other site
1266844006479	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1266844006480	domain I; other site
1266844006481	DNA binding groove [nucleotide binding]
1266844006482	phosphate binding site [ion binding]; other site
1266844006483	domain II; other site
1266844006484	domain III; other site
1266844006485	nucleotide binding site [chemical binding]; other site
1266844006486	catalytic site [active]
1266844006487	domain IV; other site
1266844006488	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1266844006489	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1266844006490	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1266844006491	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1266844006492	DNA protecting protein DprA; Region: dprA; TIGR00732
1266844006493	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1266844006494	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1266844006495	dihydroorotase; Validated; Region: pyrC; PRK09357
1266844006496	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1266844006497	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1266844006498	active site
1266844006499	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1266844006500	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1266844006501	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1266844006502	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1266844006503	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1266844006504	active site
1266844006505	HIGH motif; other site
1266844006506	nucleotide binding site [chemical binding]; other site
1266844006507	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1266844006508	active site
1266844006509	KMSKS motif; other site
1266844006510	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1266844006511	Predicted ATPase [General function prediction only]; Region: COG1485
1266844006512	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1266844006513	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1266844006514	TPP-binding site [chemical binding]; other site
1266844006515	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1266844006516	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1266844006517	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1266844006518	E3 interaction surface; other site
1266844006519	lipoyl attachment site [posttranslational modification]; other site
1266844006520	e3 binding domain; Region: E3_binding; pfam02817
1266844006521	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1266844006522	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1266844006523	E3 interaction surface; other site
1266844006524	lipoyl attachment site [posttranslational modification]; other site
1266844006525	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
1266844006526	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1266844006527	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1266844006528	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1266844006529	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
1266844006530	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1266844006531	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1266844006532	homotetramer interface [polypeptide binding]; other site
1266844006533	ligand binding site [chemical binding]; other site
1266844006534	catalytic site [active]
1266844006535	NAD binding site [chemical binding]; other site
1266844006536	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1266844006537	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1266844006538	putative acyl-acceptor binding pocket; other site
1266844006539	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
1266844006540	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1266844006541	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1266844006542	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1266844006543	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1266844006544	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
1266844006545	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1266844006546	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1266844006547	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1266844006548	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1266844006549	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1266844006550	motif 1; other site
1266844006551	active site
1266844006552	motif 2; other site
1266844006553	motif 3; other site
1266844006554	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1266844006555	TraB family; Region: TraB; cl12050
1266844006556	Predicted membrane protein [Function unknown]; Region: COG2246
1266844006557	GtrA-like protein; Region: GtrA; pfam04138
1266844006558	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1266844006559	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1266844006560	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1266844006561	ligand binding site [chemical binding]; other site
1266844006562	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1266844006563	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
1266844006564	ADP binding site [chemical binding]; other site
1266844006565	magnesium binding site [ion binding]; other site
1266844006566	putative shikimate binding site; other site
1266844006567	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1266844006568	active site
1266844006569	dimer interface [polypeptide binding]; other site
1266844006570	metal binding site [ion binding]; metal-binding site
1266844006571	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1266844006572	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1266844006573	active site
1266844006574	DNA binding site [nucleotide binding]
1266844006575	Int/Topo IB signature motif; other site
1266844006576	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1266844006577	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1266844006578	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1266844006579	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1266844006580	putative MPT binding site; other site
1266844006581	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
1266844006582	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1266844006583	active site
1266844006584	nucleotide binding site [chemical binding]; other site
1266844006585	HIGH motif; other site
1266844006586	KMSKS motif; other site
1266844006587	Predicted integral membrane protein [Function unknown]; Region: COG0392
1266844006588	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
1266844006589	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
1266844006590	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1266844006591	UGMP family protein; Validated; Region: PRK09604
1266844006592	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1266844006593	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1266844006594	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1266844006595	domain interfaces; other site
1266844006596	active site
1266844006597	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1266844006598	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1266844006599	active site
1266844006600	preprotein translocase subunit SecB; Validated; Region: PRK05751
1266844006601	SecA binding site; other site
1266844006602	Preprotein binding site; other site
1266844006603	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1266844006604	catalytic core [active]
1266844006605	Tim44-like domain; Region: Tim44; pfam04280
1266844006606	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1266844006607	DNA methylase; Region: N6_N4_Mtase; pfam01555
1266844006608	Haem-binding domain; Region: Haem_bd; pfam14376
1266844006609	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
1266844006610	Smr domain; Region: Smr; pfam01713
1266844006611	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1266844006612	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
1266844006613	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1266844006614	Qi binding site; other site
1266844006615	intrachain domain interface; other site
1266844006616	interchain domain interface [polypeptide binding]; other site
1266844006617	heme bH binding site [chemical binding]; other site
1266844006618	heme bL binding site [chemical binding]; other site
1266844006619	Qo binding site; other site
1266844006620	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
1266844006621	intrachain domain interface; other site
1266844006622	interchain domain interface [polypeptide binding]; other site
1266844006623	Qi binding site; other site
1266844006624	Qo binding site; other site
1266844006625	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
1266844006626	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
1266844006627	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
1266844006628	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1266844006629	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1266844006630	FMN binding site [chemical binding]; other site
1266844006631	dimer interface [polypeptide binding]; other site
1266844006632	ornithine cyclodeaminase; Validated; Region: PRK07340
1266844006633	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1266844006634	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1266844006635	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
1266844006636	NAD(P) binding site [chemical binding]; other site
1266844006637	catalytic residues [active]
1266844006638	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1266844006639	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1266844006640	WHG domain; Region: WHG; pfam13305
1266844006641	integrase; Provisional; Region: PRK09692
1266844006642	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1266844006643	active site
1266844006644	Int/Topo IB signature motif; other site
1266844006645	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
1266844006646	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844006647	non-specific DNA binding site [nucleotide binding]; other site
1266844006648	salt bridge; other site
1266844006649	sequence-specific DNA binding site [nucleotide binding]; other site
1266844006650	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
1266844006651	HicB family; Region: HicB; pfam05534
1266844006652	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
1266844006653	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
1266844006654	HicB family; Region: HicB; pfam05534
1266844006655	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844006656	salt bridge; other site
1266844006657	non-specific DNA binding site [nucleotide binding]; other site
1266844006658	sequence-specific DNA binding site [nucleotide binding]; other site
1266844006659	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
1266844006660	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1266844006661	AAA domain; Region: AAA_21; pfam13304
1266844006662	hypothetical protein; Validated; Region: PRK07078
1266844006663	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1266844006664	active site
1266844006665	metal binding site [ion binding]; metal-binding site
1266844006666	interdomain interaction site; other site
1266844006667	Domain of unknown function (DUF927); Region: DUF927; pfam06048
1266844006668	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1266844006669	active site
1266844006670	oligomerization interface [polypeptide binding]; other site
1266844006671	metal binding site [ion binding]; metal-binding site
1266844006672	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1266844006673	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1266844006674	active site
1266844006675	FMN binding site [chemical binding]; other site
1266844006676	substrate binding site [chemical binding]; other site
1266844006677	homotetramer interface [polypeptide binding]; other site
1266844006678	catalytic residue [active]
1266844006679	Helix-turn-helix domain; Region: HTH_20; pfam12840
1266844006680	dimerization interface [polypeptide binding]; other site
1266844006681	putative DNA binding site [nucleotide binding]; other site
1266844006682	putative Zn2+ binding site [ion binding]; other site
1266844006683	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1266844006684	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
1266844006685	putative NAD(P) binding site [chemical binding]; other site
1266844006686	putative substrate binding site [chemical binding]; other site
1266844006687	catalytic Zn binding site [ion binding]; other site
1266844006688	structural Zn binding site [ion binding]; other site
1266844006689	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1266844006690	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1266844006691	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1266844006692	NAD binding site [chemical binding]; other site
1266844006693	homodimer interface [polypeptide binding]; other site
1266844006694	active site
1266844006695	substrate binding site [chemical binding]; other site
1266844006696	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
1266844006697	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1266844006698	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1266844006699	active site
1266844006700	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1266844006701	substrate binding site [chemical binding]; other site
1266844006702	catalytic residues [active]
1266844006703	dimer interface [polypeptide binding]; other site
1266844006704	argininosuccinate lyase; Provisional; Region: PRK00855
1266844006705	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1266844006706	active sites [active]
1266844006707	tetramer interface [polypeptide binding]; other site
1266844006708	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1266844006709	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1266844006710	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1266844006711	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1266844006712	shikimate binding site; other site
1266844006713	NAD(P) binding site [chemical binding]; other site
1266844006714	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1266844006715	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1266844006716	CoA-binding site [chemical binding]; other site
1266844006717	ATP-binding [chemical binding]; other site
1266844006718	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1266844006719	active site
1266844006720	catalytic site [active]
1266844006721	substrate binding site [chemical binding]; other site
1266844006722	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1266844006723	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1266844006724	putative ADP-binding pocket [chemical binding]; other site
1266844006725	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
1266844006726	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1266844006727	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1266844006728	substrate binding site [chemical binding]; other site
1266844006729	hexamer interface [polypeptide binding]; other site
1266844006730	metal binding site [ion binding]; metal-binding site
1266844006731	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1266844006732	putative RNA binding site [nucleotide binding]; other site
1266844006733	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1266844006734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844006735	S-adenosylmethionine binding site [chemical binding]; other site
1266844006736	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1266844006737	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1266844006738	active site
1266844006739	substrate binding site [chemical binding]; other site
1266844006740	cosubstrate binding site; other site
1266844006741	catalytic site [active]
1266844006742	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1266844006743	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1266844006744	dimerization interface [polypeptide binding]; other site
1266844006745	putative ATP binding site [chemical binding]; other site
1266844006746	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1266844006747	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1266844006748	polyphosphate kinase; Provisional; Region: PRK05443
1266844006749	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1266844006750	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1266844006751	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1266844006752	putative domain interface [polypeptide binding]; other site
1266844006753	putative active site [active]
1266844006754	catalytic site [active]
1266844006755	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1266844006756	putative domain interface [polypeptide binding]; other site
1266844006757	putative active site [active]
1266844006758	catalytic site [active]
1266844006759	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1266844006760	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1266844006761	Cache domain; Region: Cache_1; pfam02743
1266844006762	cyclase homology domain; Region: CHD; cd07302
1266844006763	nucleotidyl binding site; other site
1266844006764	metal binding site [ion binding]; metal-binding site
1266844006765	dimer interface [polypeptide binding]; other site
1266844006766	Permease; Region: Permease; pfam02405
1266844006767	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1266844006768	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844006769	Q-loop/lid; other site
1266844006770	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1266844006771	mce related protein; Region: MCE; pfam02470
1266844006772	sugar binding site [chemical binding]; other site
1266844006773	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1266844006774	Inward rectifier potassium channel; Region: IRK; pfam01007
1266844006775	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1266844006776	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1266844006777	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1266844006778	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1266844006779	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
1266844006780	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1266844006781	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1266844006782	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
1266844006783	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
1266844006784	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1266844006785	catalytic residues [active]
1266844006786	central insert; other site
1266844006787	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1266844006788	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
1266844006789	heme exporter protein CcmC; Region: ccmC; TIGR01191
1266844006790	YciI-like protein; Reviewed; Region: PRK12863
1266844006791	EVE domain; Region: EVE; pfam01878
1266844006792	Putative phosphatase (DUF442); Region: DUF442; cl17385
1266844006793	EcsC protein family; Region: EcsC; pfam12787
1266844006794	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1266844006795	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1266844006796	dimerization interface [polypeptide binding]; other site
1266844006797	ligand binding site [chemical binding]; other site
1266844006798	NADP binding site [chemical binding]; other site
1266844006799	catalytic site [active]
1266844006800	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1266844006801	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
1266844006802	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
1266844006803	Protein of unknown function; Region: DUF3971; pfam13116
1266844006804	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1266844006805	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
1266844006806	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1266844006807	metal binding triad; other site
1266844006808	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1266844006809	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1266844006810	metal binding triad; other site
1266844006811	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1266844006812	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1266844006813	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1266844006814	catalytic triad [active]
1266844006815	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1266844006816	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844006817	putative substrate translocation pore; other site
1266844006818	RmuC family; Region: RmuC; pfam02646
1266844006819	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1266844006820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844006821	active site
1266844006822	phosphorylation site [posttranslational modification]
1266844006823	intermolecular recognition site; other site
1266844006824	dimerization interface [polypeptide binding]; other site
1266844006825	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1266844006826	DNA binding site [nucleotide binding]
1266844006827	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1266844006828	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1266844006829	dimerization interface [polypeptide binding]; other site
1266844006830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844006831	ATP binding site [chemical binding]; other site
1266844006832	Mg2+ binding site [ion binding]; other site
1266844006833	G-X-G motif; other site
1266844006834	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1266844006835	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1266844006836	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1266844006837	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844006838	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1266844006839	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1266844006840	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1266844006841	23S rRNA interface [nucleotide binding]; other site
1266844006842	L7/L12 interface [polypeptide binding]; other site
1266844006843	putative thiostrepton binding site; other site
1266844006844	L25 interface [polypeptide binding]; other site
1266844006845	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1266844006846	mRNA/rRNA interface [nucleotide binding]; other site
1266844006847	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1266844006848	23S rRNA interface [nucleotide binding]; other site
1266844006849	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1266844006850	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1266844006851	L11 interface [polypeptide binding]; other site
1266844006852	putative EF-Tu interaction site [polypeptide binding]; other site
1266844006853	putative EF-G interaction site [polypeptide binding]; other site
1266844006854	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1266844006855	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1266844006856	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1266844006857	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1266844006858	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1266844006859	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1266844006860	RPB1 interaction site [polypeptide binding]; other site
1266844006861	RPB11 interaction site [polypeptide binding]; other site
1266844006862	RPB10 interaction site [polypeptide binding]; other site
1266844006863	RPB3 interaction site [polypeptide binding]; other site
1266844006864	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1266844006865	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1266844006866	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1266844006867	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1266844006868	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1266844006869	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1266844006870	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1266844006871	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1266844006872	DNA binding site [nucleotide binding]
1266844006873	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1266844006874	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1266844006875	S17 interaction site [polypeptide binding]; other site
1266844006876	S8 interaction site; other site
1266844006877	16S rRNA interaction site [nucleotide binding]; other site
1266844006878	streptomycin interaction site [chemical binding]; other site
1266844006879	23S rRNA interaction site [nucleotide binding]; other site
1266844006880	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1266844006881	30S ribosomal protein S7; Validated; Region: PRK05302
1266844006882	elongation factor Tu; Reviewed; Region: PRK00049
1266844006883	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1266844006884	G1 box; other site
1266844006885	GEF interaction site [polypeptide binding]; other site
1266844006886	GTP/Mg2+ binding site [chemical binding]; other site
1266844006887	Switch I region; other site
1266844006888	G2 box; other site
1266844006889	G3 box; other site
1266844006890	Switch II region; other site
1266844006891	G4 box; other site
1266844006892	G5 box; other site
1266844006893	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1266844006894	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1266844006895	Antibiotic Binding Site [chemical binding]; other site
1266844006896	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1266844006897	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1266844006898	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1266844006899	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1266844006900	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1266844006901	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1266844006902	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1266844006903	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1266844006904	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1266844006905	putative translocon binding site; other site
1266844006906	protein-rRNA interface [nucleotide binding]; other site
1266844006907	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1266844006908	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1266844006909	G-X-X-G motif; other site
1266844006910	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1266844006911	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1266844006912	23S rRNA interface [nucleotide binding]; other site
1266844006913	5S rRNA interface [nucleotide binding]; other site
1266844006914	putative antibiotic binding site [chemical binding]; other site
1266844006915	L25 interface [polypeptide binding]; other site
1266844006916	L27 interface [polypeptide binding]; other site
1266844006917	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1266844006918	23S rRNA interface [nucleotide binding]; other site
1266844006919	putative translocon interaction site; other site
1266844006920	signal recognition particle (SRP54) interaction site; other site
1266844006921	L23 interface [polypeptide binding]; other site
1266844006922	trigger factor interaction site; other site
1266844006923	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1266844006924	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1266844006925	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1266844006926	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1266844006927	RNA binding site [nucleotide binding]; other site
1266844006928	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1266844006929	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1266844006930	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1266844006931	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1266844006932	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1266844006933	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1266844006934	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1266844006935	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1266844006936	5S rRNA interface [nucleotide binding]; other site
1266844006937	23S rRNA interface [nucleotide binding]; other site
1266844006938	L5 interface [polypeptide binding]; other site
1266844006939	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1266844006940	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1266844006941	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1266844006942	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1266844006943	23S rRNA binding site [nucleotide binding]; other site
1266844006944	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1266844006945	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1266844006946	SecY translocase; Region: SecY; pfam00344
1266844006947	adenylate kinase; Reviewed; Region: adk; PRK00279
1266844006948	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1266844006949	AMP-binding site [chemical binding]; other site
1266844006950	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1266844006951	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1266844006952	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1266844006953	30S ribosomal protein S11; Validated; Region: PRK05309
1266844006954	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1266844006955	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1266844006956	alphaNTD - beta interaction site [polypeptide binding]; other site
1266844006957	alphaNTD homodimer interface [polypeptide binding]; other site
1266844006958	alphaNTD - beta' interaction site [polypeptide binding]; other site
1266844006959	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1266844006960	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1266844006961	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1266844006962	NMT1-like family; Region: NMT1_2; pfam13379
1266844006963	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1266844006964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1266844006965	dimer interface [polypeptide binding]; other site
1266844006966	conserved gate region; other site
1266844006967	putative PBP binding loops; other site
1266844006968	ABC-ATPase subunit interface; other site
1266844006969	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1266844006970	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1266844006971	Walker A/P-loop; other site
1266844006972	ATP binding site [chemical binding]; other site
1266844006973	Q-loop/lid; other site
1266844006974	ABC transporter signature motif; other site
1266844006975	Walker B; other site
1266844006976	D-loop; other site
1266844006977	H-loop/switch region; other site
1266844006978	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1266844006979	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1266844006980	Protein export membrane protein; Region: SecD_SecF; cl14618
1266844006981	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1266844006982	Protein export membrane protein; Region: SecD_SecF; cl14618
1266844006983	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
1266844006984	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1266844006985	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844006986	putative transporter; Provisional; Region: PRK10504
1266844006987	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844006988	putative substrate translocation pore; other site
1266844006989	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844006990	CsbD-like; Region: CsbD; pfam05532
1266844006991	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
1266844006992	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1266844006993	RNA/DNA hybrid binding site [nucleotide binding]; other site
1266844006994	active site
1266844006995	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1266844006996	DNA methylase; Region: N6_N4_Mtase; pfam01555
1266844006997	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1266844006998	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1266844006999	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
1266844007000	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1266844007001	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
1266844007002	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1266844007003	Protein of unknown function DUF58; Region: DUF58; pfam01882
1266844007004	MoxR-like ATPases [General function prediction only]; Region: COG0714
1266844007005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1266844007006	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
1266844007007	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1266844007008	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1266844007009	active site
1266844007010	NTP binding site [chemical binding]; other site
1266844007011	metal binding triad [ion binding]; metal-binding site
1266844007012	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1266844007013	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1266844007014	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1266844007015	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844007016	Walker A/P-loop; other site
1266844007017	ATP binding site [chemical binding]; other site
1266844007018	Q-loop/lid; other site
1266844007019	ABC transporter signature motif; other site
1266844007020	Walker B; other site
1266844007021	D-loop; other site
1266844007022	H-loop/switch region; other site
1266844007023	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1266844007024	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1266844007025	E3 interaction surface; other site
1266844007026	lipoyl attachment site [posttranslational modification]; other site
1266844007027	HlyD family secretion protein; Region: HlyD_3; pfam13437
1266844007028	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1266844007029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1266844007030	putative substrate translocation pore; other site
1266844007031	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1266844007032	putative active site [active]
1266844007033	Ap4A binding site [chemical binding]; other site
1266844007034	nudix motif; other site
1266844007035	putative metal binding site [ion binding]; other site
1266844007036	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1266844007037	NodB motif; other site
1266844007038	putative active site [active]
1266844007039	putative catalytic site [active]
1266844007040	Zn binding site [ion binding]; other site
1266844007041	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1266844007042	C-terminal peptidase (prc); Region: prc; TIGR00225
1266844007043	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1266844007044	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1266844007045	Catalytic dyad [active]
1266844007046	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1266844007047	Peptidase family M23; Region: Peptidase_M23; pfam01551
1266844007048	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1266844007049	phosphoglyceromutase; Provisional; Region: PRK05434
1266844007050	threonine dehydratase; Provisional; Region: PRK07334
1266844007051	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1266844007052	tetramer interface [polypeptide binding]; other site
1266844007053	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844007054	catalytic residue [active]
1266844007055	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
1266844007056	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1266844007057	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1266844007058	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1266844007059	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1266844007060	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1266844007061	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1266844007062	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1266844007063	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1266844007064	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1266844007065	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1266844007066	IMP binding site; other site
1266844007067	dimer interface [polypeptide binding]; other site
1266844007068	partial ornithine binding site; other site
1266844007069	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1266844007070	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1266844007071	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1266844007072	catalytic site [active]
1266844007073	subunit interface [polypeptide binding]; other site
1266844007074	Yqey-like protein; Region: YqeY; pfam09424
1266844007075	DNA primase; Validated; Region: dnaG; PRK05667
1266844007076	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1266844007077	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1266844007078	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1266844007079	active site
1266844007080	metal binding site [ion binding]; metal-binding site
1266844007081	interdomain interaction site; other site
1266844007082	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1266844007083	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1266844007084	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1266844007085	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1266844007086	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1266844007087	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1266844007088	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1266844007089	DNA binding residues [nucleotide binding]
1266844007090	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1266844007091	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1266844007092	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1266844007093	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1266844007094	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1266844007095	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1266844007096	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1266844007097	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1266844007098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844007099	S-adenosylmethionine binding site [chemical binding]; other site
1266844007100	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1266844007101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844007102	S-adenosylmethionine binding site [chemical binding]; other site
1266844007103	SurA N-terminal domain; Region: SurA_N; pfam09312
1266844007104	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1266844007105	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1266844007106	OstA-like protein; Region: OstA; cl00844
1266844007107	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1266844007108	Predicted permeases [General function prediction only]; Region: COG0795
1266844007109	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1266844007110	Predicted permeases [General function prediction only]; Region: COG0795
1266844007111	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1266844007112	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1266844007113	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1266844007114	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844007115	Walker A/P-loop; other site
1266844007116	ATP binding site [chemical binding]; other site
1266844007117	Q-loop/lid; other site
1266844007118	ABC transporter signature motif; other site
1266844007119	Walker B; other site
1266844007120	D-loop; other site
1266844007121	H-loop/switch region; other site
1266844007122	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1266844007123	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1266844007124	DNA-binding site [nucleotide binding]; DNA binding site
1266844007125	FCD domain; Region: FCD; pfam07729
1266844007126	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
1266844007127	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1266844007128	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1266844007129	Switch I; other site
1266844007130	Switch II; other site
1266844007131	septum formation inhibitor; Reviewed; Region: minC; PRK05177
1266844007132	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1266844007133	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1266844007134	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1266844007135	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1266844007136	C-terminal domain interface [polypeptide binding]; other site
1266844007137	GSH binding site (G-site) [chemical binding]; other site
1266844007138	dimer interface [polypeptide binding]; other site
1266844007139	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1266844007140	N-terminal domain interface [polypeptide binding]; other site
1266844007141	dimer interface [polypeptide binding]; other site
1266844007142	substrate binding pocket (H-site) [chemical binding]; other site
1266844007143	Predicted flavoproteins [General function prediction only]; Region: COG2081
1266844007144	Predicted methyltransferases [General function prediction only]; Region: COG0313
1266844007145	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1266844007146	putative SAM binding site [chemical binding]; other site
1266844007147	putative homodimer interface [polypeptide binding]; other site
1266844007148	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1266844007149	putative ligand binding site [chemical binding]; other site
1266844007150	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1266844007151	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1266844007152	TPR motif; other site
1266844007153	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1266844007154	TPR motif; other site
1266844007155	binding surface
1266844007156	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1266844007157	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
1266844007158	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
1266844007159	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1266844007160	S-formylglutathione hydrolase; Region: PLN02442
1266844007161	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1266844007162	putative active site [active]
1266844007163	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1266844007164	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1266844007165	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1266844007166	Walker A/P-loop; other site
1266844007167	ATP binding site [chemical binding]; other site
1266844007168	Q-loop/lid; other site
1266844007169	ABC transporter signature motif; other site
1266844007170	Walker B; other site
1266844007171	D-loop; other site
1266844007172	H-loop/switch region; other site
1266844007173	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
1266844007174	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844007175	active site
1266844007176	phosphorylation site [posttranslational modification]
1266844007177	intermolecular recognition site; other site
1266844007178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844007179	active site
1266844007180	phosphorylation site [posttranslational modification]
1266844007181	intermolecular recognition site; other site
1266844007182	dimerization interface [polypeptide binding]; other site
1266844007183	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1266844007184	dimer interface [polypeptide binding]; other site
1266844007185	phosphorylation site [posttranslational modification]
1266844007186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844007187	ATP binding site [chemical binding]; other site
1266844007188	Mg2+ binding site [ion binding]; other site
1266844007189	G-X-G motif; other site
1266844007190	Response regulator receiver domain; Region: Response_reg; pfam00072
1266844007191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844007192	active site
1266844007193	phosphorylation site [posttranslational modification]
1266844007194	intermolecular recognition site; other site
1266844007195	dimerization interface [polypeptide binding]; other site
1266844007196	PAS fold; Region: PAS_4; pfam08448
1266844007197	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1266844007198	dimer interface [polypeptide binding]; other site
1266844007199	phosphorylation site [posttranslational modification]
1266844007200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844007201	ATP binding site [chemical binding]; other site
1266844007202	Mg2+ binding site [ion binding]; other site
1266844007203	G-X-G motif; other site
1266844007204	Response regulator receiver domain; Region: Response_reg; pfam00072
1266844007205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1266844007206	active site
1266844007207	phosphorylation site [posttranslational modification]
1266844007208	intermolecular recognition site; other site
1266844007209	dimerization interface [polypeptide binding]; other site
1266844007210	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1266844007211	active site
1266844007212	HslU subunit interaction site [polypeptide binding]; other site
1266844007213	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1266844007214	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844007215	Walker A motif; other site
1266844007216	ATP binding site [chemical binding]; other site
1266844007217	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1266844007218	Walker B motif; other site
1266844007219	arginine finger; other site
1266844007220	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1266844007221	Fe-S metabolism associated domain; Region: SufE; cl00951
1266844007222	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1266844007223	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1266844007224	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1266844007225	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1266844007226	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
1266844007227	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1266844007228	catalytic loop [active]
1266844007229	iron binding site [ion binding]; other site
1266844007230	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1266844007231	Cytochrome c; Region: Cytochrom_C; pfam00034
1266844007232	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1266844007233	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1266844007234	Cytochrome c; Region: Cytochrom_C; pfam00034
1266844007235	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1266844007236	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1266844007237	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1266844007238	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1266844007239	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1266844007240	23S rRNA binding site [nucleotide binding]; other site
1266844007241	L21 binding site [polypeptide binding]; other site
1266844007242	L13 binding site [polypeptide binding]; other site
1266844007243	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1266844007244	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1266844007245	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1266844007246	dimer interface [polypeptide binding]; other site
1266844007247	motif 1; other site
1266844007248	active site
1266844007249	motif 2; other site
1266844007250	motif 3; other site
1266844007251	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1266844007252	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1266844007253	putative tRNA-binding site [nucleotide binding]; other site
1266844007254	B3/4 domain; Region: B3_4; pfam03483
1266844007255	tRNA synthetase B5 domain; Region: B5; smart00874
1266844007256	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1266844007257	motif 1; other site
1266844007258	dimer interface [polypeptide binding]; other site
1266844007259	motif 3; other site
1266844007260	motif 2; other site
1266844007261	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
1266844007262	PBP superfamily domain; Region: PBP_like_2; cl17296
1266844007263	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
1266844007264	peptide binding site [polypeptide binding]; other site
1266844007265	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1266844007266	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1266844007267	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1266844007268	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1266844007269	ligand binding site [chemical binding]; other site
1266844007270	flexible hinge region; other site
1266844007271	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1266844007272	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1266844007273	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1266844007274	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1266844007275	RNA binding surface [nucleotide binding]; other site
1266844007276	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
1266844007277	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1266844007278	G1 box; other site
1266844007279	putative GEF interaction site [polypeptide binding]; other site
1266844007280	GTP/Mg2+ binding site [chemical binding]; other site
1266844007281	Switch I region; other site
1266844007282	G2 box; other site
1266844007283	G3 box; other site
1266844007284	Switch II region; other site
1266844007285	G4 box; other site
1266844007286	G5 box; other site
1266844007287	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1266844007288	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1266844007289	tartrate dehydrogenase; Region: TTC; TIGR02089
1266844007290	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1266844007291	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1266844007292	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1266844007293	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1266844007294	active site
1266844007295	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1266844007296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844007297	S-adenosylmethionine binding site [chemical binding]; other site
1266844007298	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1266844007299	Part of AAA domain; Region: AAA_19; pfam13245
1266844007300	Family description; Region: UvrD_C_2; pfam13538
1266844007301	hypothetical protein; Reviewed; Region: PRK00024
1266844007302	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
1266844007303	DNA repair protein radc; Region: radc; TIGR00608
1266844007304	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1266844007305	MPN+ (JAMM) motif; other site
1266844007306	Zinc-binding site [ion binding]; other site
1266844007307	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1266844007308	ATP-grasp domain; Region: ATP-grasp; pfam02222
1266844007309	AIR carboxylase; Region: AIRC; pfam00731
1266844007310	Protein of unknown function (DUF465); Region: DUF465; cl01070
1266844007311	Protein of unknown function (DUF1013); Region: DUF1013; cl11533
1266844007312	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1266844007313	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1266844007314	putative dimer interface [polypeptide binding]; other site
1266844007315	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
1266844007316	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1266844007317	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1266844007318	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1266844007319	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1266844007320	Protein export membrane protein; Region: SecD_SecF; pfam02355
1266844007321	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1266844007322	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1266844007323	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1266844007324	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1266844007325	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1266844007326	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
1266844007327	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1266844007328	active site
1266844007329	dimer interface [polypeptide binding]; other site
1266844007330	catalytic residues [active]
1266844007331	effector binding site; other site
1266844007332	R2 peptide binding site; other site
1266844007333	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1266844007334	dimer interface [polypeptide binding]; other site
1266844007335	putative radical transfer pathway; other site
1266844007336	diiron center [ion binding]; other site
1266844007337	tyrosyl radical; other site
1266844007338	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1266844007339	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1266844007340	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1266844007341	substrate binding pocket [chemical binding]; other site
1266844007342	chain length determination region; other site
1266844007343	substrate-Mg2+ binding site; other site
1266844007344	catalytic residues [active]
1266844007345	aspartate-rich region 1; other site
1266844007346	active site lid residues [active]
1266844007347	aspartate-rich region 2; other site
1266844007348	glutamate racemase; Provisional; Region: PRK00865
1266844007349	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1266844007350	active site
1266844007351	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1266844007352	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1266844007353	dimer interface [polypeptide binding]; other site
1266844007354	active site
1266844007355	citrylCoA binding site [chemical binding]; other site
1266844007356	NADH binding [chemical binding]; other site
1266844007357	cationic pore residues; other site
1266844007358	oxalacetate/citrate binding site [chemical binding]; other site
1266844007359	coenzyme A binding site [chemical binding]; other site
1266844007360	catalytic triad [active]
1266844007361	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1266844007362	catalytic core [active]
1266844007363	chorismate mutase; Provisional; Region: PRK09239
1266844007364	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1266844007365	active site
1266844007366	metal binding site [ion binding]; metal-binding site
1266844007367	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
1266844007368	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1266844007369	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1266844007370	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1266844007371	AAA domain; Region: AAA_23; pfam13476
1266844007372	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1266844007373	Walker A/P-loop; other site
1266844007374	ATP binding site [chemical binding]; other site
1266844007375	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
1266844007376	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1266844007377	ABC transporter signature motif; other site
1266844007378	Walker B; other site
1266844007379	D-loop; other site
1266844007380	H-loop/switch region; other site
1266844007381	Thioredoxin; Region: Thioredoxin_4; pfam13462
1266844007382	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1266844007383	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
1266844007384	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1266844007385	Transporter associated domain; Region: CorC_HlyC; smart01091
1266844007386	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
1266844007387	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1266844007388	PhoH-like protein; Region: PhoH; pfam02562
1266844007389	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1266844007390	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1266844007391	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844007392	FeS/SAM binding site; other site
1266844007393	TRAM domain; Region: TRAM; cl01282
1266844007394	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1266844007395	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1266844007396	putative acyl-acceptor binding pocket; other site
1266844007397	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1266844007398	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1266844007399	Surface antigen; Region: Bac_surface_Ag; pfam01103
1266844007400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1266844007401	Family of unknown function (DUF490); Region: DUF490; pfam04357
1266844007402	Family of unknown function (DUF490); Region: DUF490; pfam04357
1266844007403	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1266844007404	putative catalytic site [active]
1266844007405	putative phosphate binding site [ion binding]; other site
1266844007406	active site
1266844007407	metal binding site A [ion binding]; metal-binding site
1266844007408	DNA binding site [nucleotide binding]
1266844007409	putative AP binding site [nucleotide binding]; other site
1266844007410	putative metal binding site B [ion binding]; other site
1266844007411	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1266844007412	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1266844007413	active site
1266844007414	dimer interface [polypeptide binding]; other site
1266844007415	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1266844007416	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1266844007417	GIY-YIG motif/motif A; other site
1266844007418	active site
1266844007419	catalytic site [active]
1266844007420	putative DNA binding site [nucleotide binding]; other site
1266844007421	metal binding site [ion binding]; metal-binding site
1266844007422	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1266844007423	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1266844007424	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1266844007425	MoaE interaction surface [polypeptide binding]; other site
1266844007426	MoeB interaction surface [polypeptide binding]; other site
1266844007427	thiocarboxylated glycine; other site
1266844007428	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1266844007429	MoaE homodimer interface [polypeptide binding]; other site
1266844007430	MoaD interaction [polypeptide binding]; other site
1266844007431	active site residues [active]
1266844007432	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
1266844007433	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1266844007434	inhibitor-cofactor binding pocket; inhibition site
1266844007435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844007436	catalytic residue [active]
1266844007437	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1266844007438	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1266844007439	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1266844007440	catalytic residue [active]
1266844007441	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1266844007442	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1266844007443	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844007444	S-adenosylmethionine binding site [chemical binding]; other site
1266844007445	AAA domain; Region: AAA_26; pfam13500
1266844007446	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1266844007447	LexA repressor; Validated; Region: PRK00215
1266844007448	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1266844007449	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1266844007450	Catalytic site [active]
1266844007451	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1266844007452	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1266844007453	dimer interface [polypeptide binding]; other site
1266844007454	putative functional site; other site
1266844007455	putative MPT binding site; other site
1266844007456	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1266844007457	Septum formation initiator; Region: DivIC; cl17659
1266844007458	enolase; Provisional; Region: eno; PRK00077
1266844007459	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1266844007460	dimer interface [polypeptide binding]; other site
1266844007461	metal binding site [ion binding]; metal-binding site
1266844007462	substrate binding pocket [chemical binding]; other site
1266844007463	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
1266844007464	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1266844007465	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1266844007466	thiS-thiF/thiG interaction site; other site
1266844007467	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1266844007468	ThiS interaction site; other site
1266844007469	putative active site [active]
1266844007470	tetramer interface [polypeptide binding]; other site
1266844007471	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1266844007472	thiamine phosphate binding site [chemical binding]; other site
1266844007473	active site
1266844007474	pyrophosphate binding site [ion binding]; other site
1266844007475	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1266844007476	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1266844007477	generic binding surface II; other site
1266844007478	ssDNA binding site; other site
1266844007479	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266844007480	ATP binding site [chemical binding]; other site
1266844007481	putative Mg++ binding site [ion binding]; other site
1266844007482	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844007483	nucleotide binding region [chemical binding]; other site
1266844007484	ATP-binding site [chemical binding]; other site
1266844007485	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
1266844007486	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1266844007487	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1266844007488	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1266844007489	ATP binding site [chemical binding]; other site
1266844007490	putative Mg++ binding site [ion binding]; other site
1266844007491	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1266844007492	nucleotide binding region [chemical binding]; other site
1266844007493	ATP-binding site [chemical binding]; other site
1266844007494	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1266844007495	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
1266844007496	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1266844007497	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1266844007498	tyrosine decarboxylase; Region: PLN02880
1266844007499	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1266844007500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844007501	catalytic residue [active]
1266844007502	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
1266844007503	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
1266844007504	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1266844007505	metal ion-dependent adhesion site (MIDAS); other site
1266844007506	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
1266844007507	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
1266844007508	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1266844007509	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1266844007510	HSP70 interaction site [polypeptide binding]; other site
1266844007511	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
1266844007512	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1266844007513	lipoate-protein ligase B; Provisional; Region: PRK14341
1266844007514	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1266844007515	active site
1266844007516	tetramer interface; other site
1266844007517	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1266844007518	active site
1266844007519	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1266844007520	substrate binding site [chemical binding]; other site
1266844007521	metal binding site [ion binding]; metal-binding site
1266844007522	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1266844007523	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844007524	FeS/SAM binding site; other site
1266844007525	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1266844007526	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844007527	S-adenosylmethionine binding site [chemical binding]; other site
1266844007528	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1266844007529	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1266844007530	active site
1266844007531	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1266844007532	GSH binding site [chemical binding]; other site
1266844007533	catalytic residues [active]
1266844007534	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
1266844007535	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
1266844007536	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1266844007537	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1266844007538	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844007539	S-adenosylmethionine binding site [chemical binding]; other site
1266844007540	aspartate kinase; Reviewed; Region: PRK06635
1266844007541	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1266844007542	putative nucleotide binding site [chemical binding]; other site
1266844007543	putative catalytic residues [active]
1266844007544	putative Mg ion binding site [ion binding]; other site
1266844007545	putative aspartate binding site [chemical binding]; other site
1266844007546	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1266844007547	putative allosteric regulatory site; other site
1266844007548	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1266844007549	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1266844007550	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1266844007551	non-specific DNA binding site [nucleotide binding]; other site
1266844007552	salt bridge; other site
1266844007553	sequence-specific DNA binding site [nucleotide binding]; other site
1266844007554	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1266844007555	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1266844007556	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1266844007557	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1266844007558	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1266844007559	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1266844007560	dimer interface [polypeptide binding]; other site
1266844007561	motif 1; other site
1266844007562	active site
1266844007563	motif 2; other site
1266844007564	motif 3; other site
1266844007565	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1266844007566	anticodon binding site; other site
1266844007567	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1266844007568	PCRF domain; Region: PCRF; pfam03462
1266844007569	RF-1 domain; Region: RF-1; pfam00472
1266844007570	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1266844007571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1266844007572	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
1266844007573	mce related protein; Region: MCE; pfam02470
1266844007574	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1266844007575	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1266844007576	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1266844007577	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1266844007578	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1266844007579	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1266844007580	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1266844007581	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1266844007582	Sporulation related domain; Region: SPOR; cl10051
1266844007583	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1266844007584	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1266844007585	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1266844007586	thymidylate kinase; Validated; Region: tmk; PRK00698
1266844007587	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1266844007588	TMP-binding site; other site
1266844007589	ATP-binding site [chemical binding]; other site
1266844007590	DNA polymerase III subunit delta'; Validated; Region: PRK07471
1266844007591	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1266844007592	Walker A motif; other site
1266844007593	ATP binding site [chemical binding]; other site
1266844007594	Walker B motif; other site
1266844007595	arginine finger; other site
1266844007596	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1266844007597	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1266844007598	active site
1266844007599	HIGH motif; other site
1266844007600	KMSKS motif; other site
1266844007601	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1266844007602	tRNA binding surface [nucleotide binding]; other site
1266844007603	anticodon binding site; other site
1266844007604	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1266844007605	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1266844007606	active site
1266844007607	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1266844007608	putative hydrolase; Provisional; Region: PRK02113
1266844007609	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1266844007610	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1266844007611	Ligand Binding Site [chemical binding]; other site
1266844007612	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1266844007613	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1266844007614	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1266844007615	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
1266844007616	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1266844007617	NAD binding site [chemical binding]; other site
1266844007618	homotetramer interface [polypeptide binding]; other site
1266844007619	homodimer interface [polypeptide binding]; other site
1266844007620	substrate binding site [chemical binding]; other site
1266844007621	active site
1266844007622	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1266844007623	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1266844007624	Tetramer interface [polypeptide binding]; other site
1266844007625	active site
1266844007626	FMN-binding site [chemical binding]; other site
1266844007627	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
1266844007628	malate:quinone oxidoreductase; Validated; Region: PRK05257
1266844007629	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1266844007630	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1266844007631	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1266844007632	Ligand Binding Site [chemical binding]; other site
1266844007633	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1266844007634	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1266844007635	biotin synthase; Region: bioB; TIGR00433
1266844007636	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844007637	FeS/SAM binding site; other site
1266844007638	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1266844007639	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
1266844007640	Domain of unknown function (DUF333); Region: DUF333; pfam03891
1266844007641	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1266844007642	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1266844007643	Active Sites [active]
1266844007644	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1266844007645	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1266844007646	Active Sites [active]
1266844007647	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1266844007648	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
1266844007649	G1 box; other site
1266844007650	GTP/Mg2+ binding site [chemical binding]; other site
1266844007651	G2 box; other site
1266844007652	Switch I region; other site
1266844007653	G3 box; other site
1266844007654	Switch II region; other site
1266844007655	G4 box; other site
1266844007656	G5 box; other site
1266844007657	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1266844007658	Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G.  Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786
1266844007659	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1266844007660	ligand-binding site [chemical binding]; other site
1266844007661	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
1266844007662	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1266844007663	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1266844007664	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1266844007665	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
1266844007666	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1266844007667	putative acyl-acceptor binding pocket; other site
1266844007668	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1266844007669	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1266844007670	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1266844007671	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
1266844007672	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1266844007673	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1266844007674	putative acyl-acceptor binding pocket; other site
1266844007675	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1266844007676	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1266844007677	active site
1266844007678	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
1266844007679	putative amphipathic alpha helix; other site
1266844007680	YceG-like family; Region: YceG; pfam02618
1266844007681	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1266844007682	dimerization interface [polypeptide binding]; other site
1266844007683	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1266844007684	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1266844007685	dimer interface [polypeptide binding]; other site
1266844007686	active site
1266844007687	acyl carrier protein; Provisional; Region: acpP; PRK00982
1266844007688	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1266844007689	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1266844007690	NAD(P) binding site [chemical binding]; other site
1266844007691	active site
1266844007692	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1266844007693	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1266844007694	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1266844007695	putative active site [active]
1266844007696	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1266844007697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1266844007698	S-adenosylmethionine binding site [chemical binding]; other site
1266844007699	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1266844007700	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1266844007701	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
1266844007702	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1266844007703	DNA-binding site [nucleotide binding]; DNA binding site
1266844007704	RNA-binding motif; other site
1266844007705	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1266844007706	DNA-binding site [nucleotide binding]; DNA binding site
1266844007707	RNA-binding motif; other site
1266844007708	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1266844007709	SmpB-tmRNA interface; other site
1266844007710	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1266844007711	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1266844007712	dimer interface [polypeptide binding]; other site
1266844007713	active site
1266844007714	catalytic residue [active]
1266844007715	prephenate dehydratase; Provisional; Region: PRK11899
1266844007716	Prephenate dehydratase; Region: PDT; pfam00800
1266844007717	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1266844007718	putative L-Phe binding site [chemical binding]; other site
1266844007719	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1266844007720	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1266844007721	Ligand binding site; other site
1266844007722	oligomer interface; other site
1266844007723	Cytochrome c; Region: Cytochrom_C; cl11414
1266844007724	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1266844007725	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1266844007726	active site
1266844007727	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1266844007728	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1266844007729	ligand binding site [chemical binding]; other site
1266844007730	NAD binding site [chemical binding]; other site
1266844007731	tetramer interface [polypeptide binding]; other site
1266844007732	catalytic site [active]
1266844007733	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1266844007734	L-serine binding site [chemical binding]; other site
1266844007735	ACT domain interface; other site
1266844007736	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1266844007737	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1266844007738	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1266844007739	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1266844007740	cystathionine beta-lyase; Provisional; Region: PRK05967
1266844007741	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1266844007742	homodimer interface [polypeptide binding]; other site
1266844007743	substrate-cofactor binding pocket; other site
1266844007744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1266844007745	catalytic residue [active]
1266844007746	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1266844007747	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1266844007748	active site residue [active]
1266844007749	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1266844007750	active site residue [active]
1266844007751	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1266844007752	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1266844007753	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1266844007754	putative catalytic site [active]
1266844007755	putative metal binding site [ion binding]; other site
1266844007756	putative phosphate binding site [ion binding]; other site
1266844007757	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1266844007758	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1266844007759	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
1266844007760	putative active site [active]
1266844007761	catalytic site [active]
1266844007762	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
1266844007763	putative active site [active]
1266844007764	catalytic site [active]
1266844007765	hypothetical protein; Reviewed; Region: PRK12497
1266844007766	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1266844007767	putative GSH binding site [chemical binding]; other site
1266844007768	catalytic residues [active]
1266844007769	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
1266844007770	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1266844007771	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1266844007772	dimerization interface [polypeptide binding]; other site
1266844007773	ATP binding site [chemical binding]; other site
1266844007774	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1266844007775	dimerization interface [polypeptide binding]; other site
1266844007776	ATP binding site [chemical binding]; other site
1266844007777	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1266844007778	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1266844007779	putative active site [active]
1266844007780	catalytic triad [active]
1266844007781	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
1266844007782	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1266844007783	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1266844007784	ATP binding site [chemical binding]; other site
1266844007785	active site
1266844007786	substrate binding site [chemical binding]; other site
1266844007787	adenylosuccinate lyase; Provisional; Region: PRK07492
1266844007788	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1266844007789	tetramer interface [polypeptide binding]; other site
1266844007790	active site
1266844007791	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1266844007792	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1266844007793	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1266844007794	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1266844007795	catalytic residue [active]
1266844007796	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1266844007797	tetramer interfaces [polypeptide binding]; other site
1266844007798	binuclear metal-binding site [ion binding]; other site
1266844007799	Competence-damaged protein; Region: CinA; pfam02464
1266844007800	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1266844007801	putative coenzyme Q binding site [chemical binding]; other site
1266844007802	lipoyl synthase; Provisional; Region: PRK05481
1266844007803	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1266844007804	FeS/SAM binding site; other site
1266844007805	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1266844007806	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1266844007807	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1266844007808	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1266844007809	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
1266844007810	E3 interaction surface; other site
1266844007811	lipoyl attachment site [posttranslational modification]; other site
1266844007812	e3 binding domain; Region: E3_binding; pfam02817
1266844007813	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1266844007814	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
1266844007815	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1266844007816	E3 interaction surface; other site
1266844007817	lipoyl attachment site [posttranslational modification]; other site
1266844007818	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1266844007819	alpha subunit interface [polypeptide binding]; other site
1266844007820	TPP binding site [chemical binding]; other site
1266844007821	heterodimer interface [polypeptide binding]; other site
1266844007822	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1266844007823	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1266844007824	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1266844007825	tetramer interface [polypeptide binding]; other site
1266844007826	TPP-binding site [chemical binding]; other site
1266844007827	heterodimer interface [polypeptide binding]; other site
1266844007828	phosphorylation loop region [posttranslational modification]
1266844007829	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
1266844007830	trimer interface [polypeptide binding]; other site
1266844007831	dimer interface [polypeptide binding]; other site
1266844007832	putative active site [active]
1266844007833	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1266844007834	active site
1266844007835	ribulose/triose binding site [chemical binding]; other site
1266844007836	phosphate binding site [ion binding]; other site
1266844007837	substrate (anthranilate) binding pocket [chemical binding]; other site
1266844007838	product (indole) binding pocket [chemical binding]; other site
1266844007839	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1266844007840	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1266844007841	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1266844007842	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1266844007843	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1266844007844	glutamine binding [chemical binding]; other site
1266844007845	catalytic triad [active]
1266844007846	anthranilate synthase component I; Provisional; Region: PRK13573
1266844007847	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1266844007848	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1266844007849	SurA N-terminal domain; Region: SurA_N_3; cl07813
1266844007850	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1266844007851	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1266844007852	triosephosphate isomerase; Provisional; Region: PRK14565
1266844007853	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1266844007854	substrate binding site [chemical binding]; other site
1266844007855	dimer interface [polypeptide binding]; other site
1266844007856	catalytic triad [active]
1266844007857	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1266844007858	CTP synthetase; Validated; Region: pyrG; PRK05380
1266844007859	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1266844007860	Catalytic site [active]
1266844007861	active site
1266844007862	UTP binding site [chemical binding]; other site
1266844007863	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1266844007864	active site
1266844007865	putative oxyanion hole; other site
1266844007866	catalytic triad [active]
1266844007867	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1266844007868	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1266844007869	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1266844007870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1266844007871	ATP binding site [chemical binding]; other site
1266844007872	Mg2+ binding site [ion binding]; other site
1266844007873	G-X-G motif; other site
1266844007874	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1266844007875	anchoring element; other site
1266844007876	dimer interface [polypeptide binding]; other site
1266844007877	ATP binding site [chemical binding]; other site
1266844007878	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1266844007879	active site
1266844007880	putative metal-binding site [ion binding]; other site
1266844007881	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1266844007882	recombination protein F; Reviewed; Region: recF; PRK00064
1266844007883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844007884	Walker A/P-loop; other site
1266844007885	ATP binding site [chemical binding]; other site
1266844007886	Q-loop/lid; other site
1266844007887	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1266844007888	ABC transporter signature motif; other site
1266844007889	Walker B; other site
1266844007890	D-loop; other site
1266844007891	H-loop/switch region; other site
1266844007892	DNA polymerase III subunit beta; Validated; Region: PRK05643
1266844007893	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1266844007894	putative DNA binding surface [nucleotide binding]; other site
1266844007895	dimer interface [polypeptide binding]; other site
1266844007896	beta-clamp/translesion DNA polymerase binding surface; other site
1266844007897	beta-clamp/clamp loader binding surface; other site
1266844007898	MobA/MobL family; Region: MobA_MobL; pfam03389
1266844007899	Conjugal transfer protein TraD; Region: TraD; pfam06412
1266844007900	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
1266844007901	Replication initiator protein A; Region: RPA; pfam10134
1266844007902	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
1266844007903	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1266844007904	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1266844007905	catalytic residues [active]
1266844007906	catalytic nucleophile [active]
1266844007907	Presynaptic Site I dimer interface [polypeptide binding]; other site
1266844007908	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1266844007909	Synaptic Flat tetramer interface [polypeptide binding]; other site
1266844007910	Synaptic Site I dimer interface [polypeptide binding]; other site
1266844007911	DNA binding site [nucleotide binding]
1266844007912	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
1266844007913	DNA methylase; Region: N6_N4_Mtase; pfam01555
1266844007914	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
1266844007915	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1266844007916	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
1266844007917	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
1266844007918	Uncharacterized protein family (UPF0146); Region: UPF0146; cl00552
1266844007919	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1266844007920	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1266844007921	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1266844007922	DNA-binding interface [nucleotide binding]; DNA binding site
1266844007923	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
1266844007924	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1266844007925	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1266844007926	catalytic residues [active]
1266844007927	catalytic nucleophile [active]
1266844007928	Presynaptic Site I dimer interface [polypeptide binding]; other site
1266844007929	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1266844007930	Synaptic Flat tetramer interface [polypeptide binding]; other site
1266844007931	Synaptic Site I dimer interface [polypeptide binding]; other site
1266844007932	DNA binding site [nucleotide binding]
1266844007933	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1266844007934	DNA-binding interface [nucleotide binding]; DNA binding site
1266844007935	Helix-turn-helix domain; Region: HTH_36; pfam13730
1266844007936	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396