-- dump date   	20250517_150157
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
LALA0_S01e00100g	some similarities with uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S01e00122g	similar to Lachancea thermotolerans KLTH0E03080g hypothetical protein
LALA0_S01e00144g	some similarities with uniprot|L9PLA9 Janthinobacterium sp. HH01 Jab_1c02220 NAD-dependent epimerase/dehydratase
LALA0_S01e00166g	similar to uniprot|P35842 Saccharomyces cerevisiae YAR071W PHO11 One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
LALA0_S01e00188g	weakly similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
LALA0_S01e00210g	similar to uniprot|Q08912 Saccharomyces cerevisiae YOR389W Putative protein of unknown function; expression regulated by copper levels
LALA0_S01e00232g	hypothetical protein
LALA0_S01e00254g	similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S01e00276g	highly similar to uniprot|G8YIZ4 Millerozyma farinosa Piso0_003402 hypothetical protein
LALA0_S01e00298g	weakly similar to uniprot|P39529 Saccharomyces cerevisiae YJL206C Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment
LALA0_S01e00320g	similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
LALA0_S01e00342g	highly similar to uniprot|P28273 Saccharomyces cerevisiae YKL215C OXP1 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S01e00364g	similar to uniprot|P43623 Saccharomyces cerevisiae YFR055W IRC7 Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner
LALA0_S01e00386g	similar to uniprot|P38776 Saccharomyces cerevisiae YHR048W YHK8 Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
LALA0_S01e00408g	weakly similar to uniprot|P25608 Saccharomyces cerevisiae YCR102C Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family
LALA0_S01e00430g	similar to uniprot|O94493 Schizosaccharomyces pombe carboxylesterase-lipase family protein
LALA0_S01e00452g	weakly similar to uniprot|P53750 Saccharomyces cerevisiae YNR064C Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
LALA0_S01e00474g	weakly similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C HER2 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
LALA0_S01e00496g	similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
LALA0_S01e00518g	weakly similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C HER2 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
LALA0_S01e00540g	similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
LALA0_S01e00562g	similar to Tatumella ptyseos 1-aminocyclopropane-1-carboxylate deaminase
LALA0_S01e00584g	weakly similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
LALA0_S01e00606g	weakly similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
LALA0_S01e00628g	highly similar to uniprot|C5DIZ1 Lachancea thermotolerans KLTH0E16302g hypothetical protein
LALA0_S01e00650g	weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane
LALA0_S01e00672g	highly similar to uniprot|P53051 Saccharomyces cerevisiae YGR287C IMA1 Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization; has specificity for isomaltose, palatinose, and methyl-alpha-glucoside; member of the IMA isomaltase family
LALA0_S01e00694g	highly similar to uniprot|P43548 Saccharomyces cerevisiae YFL055W AGP3 Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
LALA0_S01e00716g	similar to uniprot|P38731 Saccharomyces cerevisiae YHL040C ARN1 Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
LALA0_S01e00738g	similar to uniprot|P53889 Saccharomyces cerevisiae YNL168C FMP41 Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S01e00760g	similar to uniprot|P04817 Saccharomyces cerevisiae YEL063C (ohnolog of YNL270C) CAN1 Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance
LALA0_S01e00782g	some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p
LALA0_S01e00804g	similar to uniprot|Q04869 Saccharomyces cerevisiae YMR315W Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site
LALA0_S01e00826g	similar to uniprot|P05085 Saccharomyces cerevisiae YML099C ARG81 Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
LALA0_S01e00848g	similar to uniprot|P11747 Saccharomyces cerevisiae YML098W TAF13 TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
LALA0_S01e00870g	similar to uniprot|Q03103 Saccharomyces cerevisiae YML130C ERO1 Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
LALA0_S01e00892g	similar to uniprot|P54787 Saccharomyces cerevisiae YML097C VPS9 A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
LALA0_S01e00914g	similar to uniprot|Q04489 Saccharomyces cerevisiae YML096W Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
LALA0_S01e00936g	similar to uniprot|P06838 Saccharomyces cerevisiae YML095C RAD10 Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
LALA0_S01e00958g	similar to uniprot|Q04493 Saccharomyces cerevisiae YML094W GIM5 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
LALA0_S01e00980g	similar to uniprot|Q04500 Saccharomyces cerevisiae YML093W UTP14 Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
LALA0_S01e01002g	highly similar to uniprot|P23639 Saccharomyces cerevisiae YML092C PRE8 Alpha 2 subunit of the 20S proteasome
LALA0_S01e01024g	similar to uniprot|C5DIZ0 Lachancea thermotolerans KLTH0E16280g hypothetical protein
LALA0_S01e01046g	similar to uniprot|C5DIX2 Lachancea thermotolerans KLTH0E15862g hypothetical protein
LALA0_S01e01068g	similar to uniprot|P39103 Saccharomyces cerevisiae YML129C COX14 Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
LALA0_S01e01090g	weakly similar to uniprot|Q03104 Saccharomyces cerevisiae YML128C MSC1 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
LALA0_S01e01112g	similar to uniprot|Q03124 Saccharomyces cerevisiae YML127W RSC9 Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
LALA0_S01e01134g	similar to uniprot|Q02773 Saccharomyces cerevisiae YML091C RPM2 Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
LALA0_S01e01156g	highly similar to uniprot|P54839 Saccharomyces cerevisiae YML126C ERG13 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
LALA0_S01e01200g	similar to uniprot|P35845 Saccharomyces cerevisiae YAR042W (ohnolog of YDL019C) SWH1 Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
LALA0_S01e01222g	similar to uniprot|P80235 Saccharomyces cerevisiae YAR035W YAT1 Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
LALA0_S01e01244g	similar to uniprot|P27636 Saccharomyces cerevisiae YAR019C CDC15 Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II
LALA0_S01e01266g	similar to uniprot|P22209 Saccharomyces cerevisiae YAR018C KIN3 Nonessential serine/threonine protein kinase; possible role in DNA damage response
LALA0_S01e01288g	highly similar to uniprot|P27616 Saccharomyces cerevisiae YAR015W ADE1 N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine
LALA0_S01e01310g	weakly similar to uniprot|P27637 Saccharomyces cerevisiae YAR014C BUD14 Protein involved in bud-site selection, Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
LALA0_S01e01332g	similar to uniprot|P38217 Saccharomyces cerevisiae YBR017C KAP104 Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis
LALA0_S01e01354g	similar to uniprot|P32375 Saccharomyces cerevisiae YIR027C DAL1 Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
LALA0_S01e01376g	weakly similar to uniprot|Q12403 Saccharomyces cerevisiae YDL018C ERP3 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
LALA0_S01e01398g	similar to uniprot|P06243 Saccharomyces cerevisiae YDL017W CDC7 DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression
LALA0_S01e01420g	similar to uniprot|Q99190 Saccharomyces cerevisiae YDL015C TSC13 Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p
LALA0_S01e01442g	highly similar to uniprot|P15646 Saccharomyces cerevisiae YDL014W NOP1 Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
LALA0_S01e01464g	weakly similar to uniprot|P32828 Saccharomyces cerevisiae YDL013W SLX5 Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers
LALA0_S01e01486g	similar to uniprot|C5DIV3 Lachancea thermotolerans KLTH0E15444g hypothetical protein
LALA0_S01e01508g	similar to uniprot|P38216 Saccharomyces cerevisiae YBR016W (ohnolog of YDL012C) Tail-anchored plasma membrane protein containing a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions
LALA0_S01e01530g	weakly similar to uniprot|P38277 Saccharomyces cerevisiae YBR138C Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
LALA0_S01e01552g	similar to uniprot|P38276 Saccharomyces cerevisiae YBR137W Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene
LALA0_S01e01574g	similar to uniprot|Q08234 Saccharomyces cerevisiae YOL075C Putative ABC transporter
LALA0_S01e01596g	similar to uniprot|P48363 Saccharomyces cerevisiae YGR078C PAC10 Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding
LALA0_S01e01618g	similar to uniprot|Q08232 Saccharomyces cerevisiae YOL073C Putative protein of unknown function
LALA0_S01e01640g	weakly similar to uniprot|P53248 Saccharomyces cerevisiae YGR077C PEX8 Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p
LALA0_S01e01662g	highly similar to uniprot|P38074 Saccharomyces cerevisiae YBR034C HMT1 Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p
LALA0_S01e01684g	highly similar to uniprot|P49626 Saccharomyces cerevisiae YDR012W (ohnolog of YBR031W) RPL4B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
LALA0_S01e01706g	highly similar to uniprot|P19145 Saccharomyces cerevisiae YKR039W GAP1 General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed
LALA0_S01e01728g	highly similar to uniprot|P36132 Saccharomyces cerevisiae YKR038C KAE1 Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
LALA0_S01e01750g	similar to uniprot|P36131 Saccharomyces cerevisiae YKR037C SPC34 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
LALA0_S01e01772g	similar to uniprot|P47025 Saccharomyces cerevisiae YJL112W (ohnolog of YKR036C) MDV1 Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats
LALA0_S01e01794g	highly similar to uniprot|P42943 Saccharomyces cerevisiae YJL111W CCT7 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
LALA0_S01e01816g	highly similar to uniprot|P69771 Saccharomyces cerevisiae YKR035W-A DID2 Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
LALA0_S01e01838g	weakly similar to uniprot|P42944 Saccharomyces cerevisiae YJL110C (ohnolog of YKR034W) GZF3 GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p
LALA0_S01e01860g	similar to uniprot|P36126 Saccharomyces cerevisiae YKR031C SPO14 Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis
LALA0_S01e01882g	similar to uniprot|C5DIV2 Lachancea thermotolerans KLTH0E15422g hypothetical protein
LALA0_S01e01904g	similar to Lachancea thermotolerans KLTH0D00242g hypothetical protein
LALA0_S01e01926g	similar to uniprot|P36125 Saccharomyces cerevisiae YKR030W GMH1 Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
LALA0_S01e01948g	similar to uniprot|P42945 Saccharomyces cerevisiae YJL109C UTP10 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
LALA0_S01e01970g	some similarities with uniprot|P42946 Saccharomyces cerevisiae YJL108C PRM10 Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
LALA0_S01e02036g	similar to uniprot|P38263 Saccharomyces cerevisiae YBR105C VID24 Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase
LALA0_S01e02058g	similar to uniprot|Q12160 Saccharomyces cerevisiae YPR063C ER-localized protein of unknown function
LALA0_S01e02080g	similar to uniprot|Q12350 Saccharomyces cerevisiae YPR061C JID1 Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
LALA0_S01e02102g	highly similar to uniprot|P32178 Saccharomyces cerevisiae YPR060C ARO7 Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
LALA0_S01e02124g	similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W (ohnolog of YPR058W) YMC2 Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
LALA0_S01e02146g	highly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C (ohnolog of YER057C) MMF1 Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
LALA0_S01e02168g	highly similar to uniprot|P40525 Saccharomyces cerevisiae YIL052C (ohnolog of YER056C-A) RPL34B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
LALA0_S01e02190g	similar to uniprot|Q02771 Saccharomyces cerevisiae YER058W PET117 Protein required for assembly of cytochrome c oxidase
LALA0_S01e02212g	some similarities with uniprot|P40186 Saccharomyces cerevisiae YIL050W (ohnolog of YER059W) PCL7 Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
LALA0_S01e02234g	similar to uniprot|P17064 Saccharomyces cerevisiae YER056C FCY2 Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation
LALA0_S01e02256g	similar to uniprot|P40526 Saccharomyces cerevisiae YIL049W DFG10 Probable polyprenol reductase that catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human ortholog SRD5A3 confer CDG (Congenital Disorders of Glycosylation)
LALA0_S01e02278g	similar to uniprot|P39525 Saccharomyces cerevisiae YER061C CEM1 Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
LALA0_S01e02300g	weakly similar to Lachancea thermotolerans KLTH0D10516g hypothetical protein
LALA0_S01e02322g	highly similar to uniprot|P41277 Saccharomyces cerevisiae YIL053W (ohnolog of YER062C HOR2) RHR2 Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
LALA0_S01e02344g	weakly similar to uniprot|P40040 Saccharomyces cerevisiae YER063W THO1 Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
LALA0_S01e02366g	some similarities with uniprot|P40523 Saccharomyces cerevisiae YIL055C Putative protein of unknown function
LALA0_S01e02388g	similar to uniprot|P40522 Saccharomyces cerevisiae YIL056W (ohnolog of YER064C) VHR1 Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
LALA0_S01e02410g	highly similar to uniprot|P28240 Saccharomyces cerevisiae YER065C ICL1 Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
LALA0_S01e02454g	similar to uniprot|P40188 Saccharomyces cerevisiae YIL057C (ohnolog of YER067W) RGI2 Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose
LALA0_S01e02476g	similar to uniprot|P34909 Saccharomyces cerevisiae YER068W MOT2 Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p
LALA0_S01e02498g	similar to uniprot|Q00916 Saccharomyces cerevisiae YIL061C SNP1 Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein
LALA0_S01e02520g	highly similar to uniprot|Q01217 Saccharomyces cerevisiae YER069W ARG5,6 Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
LALA0_S01e02542g	highly similar to uniprot|P40518 Saccharomyces cerevisiae YIL062C ARC15 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity
LALA0_S01e02564g	weakly similar to uniprot|P40517 Saccharomyces cerevisiae YIL063C YRB2 Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
LALA0_S01e02586g	similar to uniprot|P40516 Saccharomyces cerevisiae YIL064W SEE1 Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport
LALA0_S01e02608g	similar to uniprot|P40515 Saccharomyces cerevisiae YIL065C FIS1 Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
LALA0_S01e02630g	highly similar to uniprot|P21672 Saccharomyces cerevisiae YIL066C (ohnolog of YER070W) RNR3 Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
LALA0_S01e02652g	similar to uniprot|P40514 Saccharomyces cerevisiae YIL067C Uncharacterized protein of unknown function
LALA0_S01e02674g	similar to uniprot|P32844 Saccharomyces cerevisiae YIL068C SEC6 Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly
LALA0_S01e02696g	similar to uniprot|P40045 Saccharomyces cerevisiae YER071C TDA2 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
LALA0_S01e02718g	highly similar to uniprot|P40046 Saccharomyces cerevisiae YER072W VTC1 Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity
LALA0_S01e02762g	highly similar to uniprot|P40047 Saccharomyces cerevisiae YER073W ALD5 Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
LALA0_S01e02784g	highly similar to uniprot|P26782 Saccharomyces cerevisiae YIL069C (ohnolog of YER074W) RPS24B Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
LALA0_S01e02806g	similar to uniprot|Q3E834 Saccharomyces cerevisiae YER074W-A YOS1 Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p
LALA0_S01e02828g	similar to uniprot|P40048 Saccharomyces cerevisiae YER075C PTP3 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
LALA0_S01e02850g	similar to uniprot|P40513 Saccharomyces cerevisiae YIL070C MAM33 Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
LALA0_S01e02872g	similar to uniprot|P40050 Saccharomyces cerevisiae YER077C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
LALA0_S01e02894g	similar to uniprot|P40512 Saccharomyces cerevisiae YIL071C PCI8 Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
LALA0_S01e02916g	similar to uniprot|P40051 Saccharomyces cerevisiae YER078C ICP55 Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family
LALA0_S01e02938g	similar to uniprot|P20050 Saccharomyces cerevisiae YIL072W HOP1 Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation
LALA0_S01e02960g	weakly similar to uniprot|P40052 Saccharomyces cerevisiae YER079W Putative protein of unknown function
LALA0_S01e02982g	similar to uniprot|P40053 Saccharomyces cerevisiae YER080W AIM9 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S01e03004g	highly similar to uniprot|P40510 Saccharomyces cerevisiae YIL074C (ohnolog of YER081W) SER33 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
LALA0_S01e03026g	highly similar to uniprot|P32565 Saccharomyces cerevisiae YIL075C RPN2 Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p
LALA0_S01e03048g	highly similar to uniprot|P40055 Saccharomyces cerevisiae YER082C UTP7 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
LALA0_S01e03070g	similar to uniprot|Q03028 Saccharomyces cerevisiae YPL134C (ohnolog of YOR222W) ODC1 Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
LALA0_S01e03092g	similar to uniprot|Q12015 Saccharomyces cerevisiae YOR223W Protein of unknown function found in the ER and vacuole lumen; overexpression of YOR223W affects endocytic protein trafficking
LALA0_S01e03114g	highly similar to uniprot|C5DEZ1 Lachancea thermotolerans KLTH0D10912g hypothetical protein
LALA0_S01e03136g	highly similar to uniprot|P20436 Saccharomyces cerevisiae YOR224C RPB8 RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
LALA0_S01e03158g	highly similar to uniprot|Q03020 Saccharomyces cerevisiae YPL135W (ohnolog of YOR226C) ISU1 Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
LALA0_S01e03180g	similar to uniprot|Q03016 Saccharomyces cerevisiae YPL137C (ohnolog of YOR227W) GIP3 Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
LALA0_S01e03202g	similar to uniprot|Q12106 Saccharomyces cerevisiae YOR228C Protein of unknown function, localized to the mitochondrial outer membrane
LALA0_S01e03224g	similar to uniprot|Q03012 Saccharomyces cerevisiae YPL138C SPP1 Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein
LALA0_S01e03246g	similar to uniprot|Q03010 Saccharomyces cerevisiae YPL139C (ohnolog of YOR229W) UME1 Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
LALA0_S01e03268g	similar to uniprot|P32491 Saccharomyces cerevisiae YPL140C (ohnolog of YOR231W) MKK2 Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p
LALA0_S01e03290g	similar to uniprot|P38523 Saccharomyces cerevisiae YOR232W MGE1 Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
LALA0_S01e03312g	similar to uniprot|Q03002 Saccharomyces cerevisiae YPL141C (ohnolog of YOR233W) FRK1 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3
LALA0_S01e03334g	highly similar to uniprot|P05744 Saccharomyces cerevisiae YPL143W (ohnolog of YOR234C) RPL33A N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
LALA0_S01e03356g	similar to uniprot|Q12245 Saccharomyces cerevisiae YPL144W POC4 Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
LALA0_S01e03378g	similar to uniprot|P07807 Saccharomyces cerevisiae YOR236W DFR1 Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
LALA0_S01e03400g	highly similar to uniprot|P35844 Saccharomyces cerevisiae YPL145C (ohnolog of YOR237W) KES1 Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
LALA0_S01e03422g	similar to uniprot|Q12080 Saccharomyces cerevisiae YPL146C NOP53 Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
LALA0_S01e03444g	similar to uniprot|Q08634 Saccharomyces cerevisiae YOR238W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S01e03466g	similar to uniprot|P41909 Saccharomyces cerevisiae YPL147W PXA1 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
LALA0_S01e03488g	highly similar to Lachancea thermotolerans KLTH0D10934g hypothetical protein
LALA0_S01e03510g	similar to uniprot|C5DEZ5 Lachancea thermotolerans KLTH0D11022g hypothetical protein
LALA0_S01e03532g	weakly similar to uniprot|Q12036 Saccharomyces cerevisiae YPL148C PPT2 Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation
LALA0_S01e03554g	similar to uniprot|Q08641 Saccharomyces cerevisiae YOR239W ABP140 AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift
LALA0_S01e03576g	similar to uniprot|Q12380 Saccharomyces cerevisiae YPL149W ATG5 Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
LALA0_S01e03598g	similar to uniprot|C5DF18 Lachancea thermotolerans KLTH0D11528g hypothetical protein
LALA0_S01e03620g	similar to uniprot|Q12152 Saccharomyces cerevisiae YPL150W Putative protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study
LALA0_S01e03642g	similar to uniprot|Q08645 Saccharomyces cerevisiae YOR241W MET7 Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA
LALA0_S01e03664g	weakly similar to uniprot|Q96US5 Saccharomyces cerevisiae YOR242C SSP2 Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
LALA0_S01e03686g	similar to uniprot|Q08647 Saccharomyces cerevisiae YOR243C PUS7 Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria
LALA0_S01e03708g	similar to uniprot|Q12417 Saccharomyces cerevisiae YPL151C PRP46 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
LALA0_S01e03730g	highly similar to uniprot|Q08649 Saccharomyces cerevisiae YOR244W ESA1 Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus
LALA0_S01e03752g	similar to uniprot|Q12461 Saccharomyces cerevisiae YPL152W RRD2 Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex
LALA0_S01e03774g	similar to uniprot|Q08650 Saccharomyces cerevisiae YOR245C DGA1 Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
LALA0_S01e03796g	similar to uniprot|P22216 Saccharomyces cerevisiae YPL153C RAD53 Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
LALA0_S01e03818g	highly similar to uniprot|P07267 Saccharomyces cerevisiae YPL154C PEP4 Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates
LALA0_S01e03840g	similar to uniprot|P28743 Saccharomyces cerevisiae YPL155C KIP2 Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle
LALA0_S01e03862g	weakly similar to uniprot|Q12498 Saccharomyces cerevisiae YPL156C PRM4 Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
LALA0_S01e03884g	similar to uniprot|Q12052 Saccharomyces cerevisiae YPL157W TGS1 Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
LALA0_S01e03906g	weakly similar to uniprot|Q99299 Saccharomyces cerevisiae YPL158C AIM44 Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S01e03928g	similar to uniprot|Q03649 Saccharomyces cerevisiae YMR210W Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
LALA0_S01e03950g	similar to uniprot|Q99373 Saccharomyces cerevisiae YPL159C PET20 Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome
LALA0_S01e03972g	highly similar to uniprot|P26637 Saccharomyces cerevisiae YPL160W CDC60 Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
LALA0_S01e03994g	similar to uniprot|Q08651 Saccharomyces cerevisiae YOR246C Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
LALA0_S01e04016g	similar to uniprot|P39011 Saccharomyces cerevisiae YPL161C BEM4 Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length
LALA0_S01e04038g	similar to uniprot|Q12042 Saccharomyces cerevisiae YPL162C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology
LALA0_S01e04060g	similar to uniprot|C5DF63 Lachancea thermotolerans KLTH0D12540g hypothetical protein
LALA0_S01e04082g	weakly similar to uniprot|Q12083 Saccharomyces cerevisiae YPL164C MLH3 Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
LALA0_S01e04104g	weakly similar to uniprot|Q08683 Saccharomyces cerevisiae YOR249C APC5 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis
LALA0_S01e04126g	similar to uniprot|Q08685 Saccharomyces cerevisiae YOR250C CLP1 Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
LALA0_S01e04148g	similar to uniprot|Q08686 Saccharomyces cerevisiae YOR251C TUM1 Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized
LALA0_S01e04170g	similar to uniprot|Q12092 Saccharomyces cerevisiae YPL166W ATG29 Autophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved
LALA0_S01e04192g	similar to uniprot|P14284 Saccharomyces cerevisiae YPL167C REV3 Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
LALA0_S01e04214g	similar to uniprot|Q08687 Saccharomyces cerevisiae YOR252W TMA16 Protein of unknown function that associates with ribosomes
LALA0_S01e04236g	weakly similar to uniprot|Q12467 Saccharomyces cerevisiae YPL168W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated
LALA0_S01e04258g	similar to uniprot|Q08689 Saccharomyces cerevisiae YOR253W NAT5 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
LALA0_S01e04280g	similar to uniprot|P14906 Saccharomyces cerevisiae YOR254C SEC63 Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
LALA0_S01e04302g	similar to uniprot|Q99257 Saccharomyces cerevisiae YPL169C MEX67 Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
LALA0_S01e04324g	weakly similar to uniprot|Q08692 Saccharomyces cerevisiae YOR255W OSW1 Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
LALA0_S01e04346g	highly similar to uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
LALA0_S01e04368g	similar to uniprot|Q08919 Saccharomyces cerevisiae YPL176C (ohnolog of YOR256C) TRE1 Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors
LALA0_S01e04390g	similar to uniprot|P32363 Saccharomyces cerevisiae YPL175W SPT14 UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
LALA0_S01e04412g	weakly similar to uniprot|P33420 Saccharomyces cerevisiae YPL174C NIP100 Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
LALA0_S01e04434g	highly similar to uniprot|P06704 Saccharomyces cerevisiae YOR257W CDC31 Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
LALA0_S01e04456g	similar to uniprot|P36534 Saccharomyces cerevisiae YPL173W MRPL40 Mitochondrial ribosomal protein of the large subunit
LALA0_S01e04478g	similar to uniprot|Q08702 Saccharomyces cerevisiae YOR258W HNT3 DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia
LALA0_S01e04500g	highly similar to uniprot|P53549 Saccharomyces cerevisiae YOR259C RPT4 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization
LALA0_S01e04522g	similar to uniprot|P09032 Saccharomyces cerevisiae YOR260W GCD1 Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
LALA0_S01e04544g	similar to uniprot|P21592 Saccharomyces cerevisiae YPL172C COX10 Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders
LALA0_S01e04566g	highly similar to uniprot|Q08723 Saccharomyces cerevisiae YOR261C RPN8 Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p
LALA0_S01e04588g	highly similar to uniprot|Q08726 Saccharomyces cerevisiae YOR262W Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B
LALA0_S01e04610g	weakly similar to uniprot|Q08729 Saccharomyces cerevisiae YOR264W DSE3 Daughter cell-specific protein, may help establish daughter fate
LALA0_S01e04632g	similar to uniprot|P48606 Saccharomyces cerevisiae YOR265W RBL2 Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A
LALA0_S01e04654g	similar to uniprot|P38969 Saccharomyces cerevisiae YOR266W PNT1 Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
LALA0_S01e04676g	similar to uniprot|Q07224 Saccharomyces cerevisiae YOR267C HRK1 Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis
LALA0_S01e04698g	similar to uniprot|P39946 Saccharomyces cerevisiae YOR269W PAC1 Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1
LALA0_S01e04720g	similar to uniprot|P32563 Saccharomyces cerevisiae YOR270C VPH1 Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
LALA0_S01e04742g	similar to uniprot|P07277 Saccharomyces cerevisiae YMR208W ERG12 Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
LALA0_S01e04764g	highly similar to uniprot|Q12029 Saccharomyces cerevisiae YOR271C FSF1 Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
LALA0_S01e04808g	highly similar to uniprot|Q12024 Saccharomyces cerevisiae YOR272W YTM1 Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
LALA0_S01e04830g	similar to uniprot|Q03648 Saccharomyces cerevisiae YMR209C Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene
LALA0_S01e04852g	similar to uniprot|Q12256 Saccharomyces cerevisiae YOR273C TPO4 Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
LALA0_S01e04874g	similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W Protein of unknown function, differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S01e04896g	similar to uniprot|Q03652 Saccharomyces cerevisiae YMR211W DML1 Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
LALA0_S01e04918g	similar to uniprot|P07884 Saccharomyces cerevisiae YOR274W MOD5 Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
LALA0_S01e04940g	similar to uniprot|Q12033 Saccharomyces cerevisiae YOR275C RIM20 Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
LALA0_S01e04962g	similar to uniprot|Q03653 Saccharomyces cerevisiae YMR212C EFR3 Protein required for Stt4-containing phosphoinositide kinase patch assembly at the plasma membrane; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout (RBO) gene
LALA0_S01e04984g	similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
LALA0_S01e05006g	similar to uniprot|P12962 Saccharomyces cerevisiae YOR276W CAF20 Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
LALA0_S01e05028g	similar to uniprot|P25303 Saccharomyces cerevisiae YMR214W SCJ1 One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
LALA0_S01e05050g	similar to uniprot|Q03656 Saccharomyces cerevisiae YMR216C SKY1 SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
LALA0_S01e05072g	similar to uniprot|C5DCP7 Lachancea thermotolerans KLTH0B04796g hypothetical protein
LALA0_S01e05094g	similar to uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
LALA0_S01e05116g	highly similar to uniprot|P38625 Saccharomyces cerevisiae YMR217W GUA1 GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA
LALA0_S01e05138g	similar to uniprot|P06174 Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
LALA0_S01e05160g	similar to uniprot|Q03660 Saccharomyces cerevisiae YMR218C TRS130 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1
LALA0_S01e05182g	weakly similar to uniprot|Q03661 Saccharomyces cerevisiae YMR219W ESC1 Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p
LALA0_S01e05204g	similar to uniprot|P24521 Saccharomyces cerevisiae YMR220W ERG8 Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
LALA0_S01e05226g	weakly similar to uniprot|Q12192 Saccharomyces cerevisiae YOR279C RFM1 DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
LALA0_S01e05248g	similar to uniprot|Q04991 Saccharomyces cerevisiae YMR221C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
LALA0_S01e05270g	similar to uniprot|Q99369 Saccharomyces cerevisiae YOR280C (ohnolog of YMR222C) FSH3 Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2
LALA0_S01e05292g	similar to uniprot|P34217 Saccharomyces cerevisiae YBL051C PIN4 Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
LALA0_S01e05314g	highly similar to uniprot|P52871 Saccharomyces cerevisiae YER019C-A (ohnolog of YER087C-B SBH1) SBH2 Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
LALA0_S01e05336g	similar to uniprot|P39965 Saccharomyces cerevisiae YER087W AIM10 Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
LALA0_S01e05358g	highly similar to uniprot|P00927 Saccharomyces cerevisiae YER086W ILV1 Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
LALA0_S01e05380g	weakly similar to uniprot|Q06324 Saccharomyces cerevisiae YLR190W MMR1 Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
LALA0_S01e05424g	similar to uniprot|P80667 Saccharomyces cerevisiae YLR191W PEX13 Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
LALA0_S01e05446g	similar to uniprot|Q12491 Saccharomyces cerevisiae TY2B-B transposon Ty2-B Gag-Pol polyprotein
LALA0_S01e05490g	similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
LALA0_S01e05512g	similar to uniprot|Q05775 Saccharomyces cerevisiae YLR192C HCR1 Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
LALA0_S01e05534g	some similarities with uniprot|Q6Q543 Saccharomyces cerevisiae YDL173W PAR32 Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
LALA0_S01e05556g	highly similar to uniprot|Q12680 Saccharomyces cerevisiae YDL171C GLT1 NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
LALA0_S01e05578g	hypothetical protein
LALA0_S01e05600g	similar to uniprot|P36009 Saccharomyces cerevisiae YKL078W DHR2 Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
LALA0_S01e05622g	weakly similar to uniprot|Q04734 Saccharomyces cerevisiae YMR063W RIM9 Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein
LALA0_S01e05644g	weakly similar to uniprot|P32493 Saccharomyces cerevisiae YMR064W AEP1 Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase
LALA0_S01e05666g	weakly similar to uniprot|Q04746 Saccharomyces cerevisiae YMR065W KAR5 Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone
LALA0_S01e05688g	highly similar to uniprot|P16861 Saccharomyces cerevisiae YGR240C PFK1 Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
LALA0_S01e05710g	weakly similar to uniprot|P38856 Saccharomyces cerevisiae YHR161C (ohnolog of YGR241C) YAP1801 Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family
LALA0_S01e05732g	weakly similar to uniprot|C5DE44 Lachancea thermotolerans KLTH0C06160g hypothetical protein
LALA0_S01e05754g	highly similar to uniprot|P07251 Saccharomyces cerevisiae YBL099W ATP1 Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
LALA0_S01e05776g	similar to uniprot|P37366 Saccharomyces cerevisiae YPR025C CCL1 Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
LALA0_S01e05798g	highly similar to uniprot|P32795 Saccharomyces cerevisiae YPR024W YME1 Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
LALA0_S01e05820g	similar to uniprot|P38170 Saccharomyces cerevisiae YBL097W BRN1 Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission
LALA0_S01e05842g	similar to uniprot|P38169 Saccharomyces cerevisiae YBL098W BNA4 Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
LALA0_S01e05864g	weakly similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C (ohnolog of YOL103W) ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
LALA0_S01e05886g	similar to uniprot|P38172 Saccharomyces cerevisiae YBL095W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S01e05908g	similar to uniprot|P38682 Saccharomyces cerevisiae YER122C GLO3 ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p
LALA0_S01e05930g	similar to uniprot|P25046 Saccharomyces cerevisiae YBL093C ROX3 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme
LALA0_S01e05952g	highly similar to uniprot|P38061 Saccharomyces cerevisiae YBL092W RPL32 Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
LALA0_S01e05974g	similar to uniprot|P40075 Saccharomyces cerevisiae YER120W (ohnolog of YBL091C-A) SCS2 Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog
LALA0_S01e05996g	highly similar to uniprot|P38174 Saccharomyces cerevisiae YBL091C MAP2 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p
LALA0_S01e06018g	weakly similar to uniprot|P38175 Saccharomyces cerevisiae YBL090W MRP21 Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
LALA0_S01e06040g	similar to uniprot|P40074 Saccharomyces cerevisiae YER119C (ohnolog of YBL089W) AVT6 Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation
LALA0_S01e06062g	similar to uniprot|P40073 Saccharomyces cerevisiae YER118C SHO1 Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
LALA0_S01e06084g	similar to uniprot|P38110 Saccharomyces cerevisiae YBL088C TEL1 Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene
LALA0_S01e06106g	highly similar to uniprot|P04451 Saccharomyces cerevisiae YER117W (ohnolog of YBL087C) RPL23B Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
LALA0_S01e06128g	weakly similar to uniprot|P40072 Saccharomyces cerevisiae YER116C SLX8 Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain
LALA0_S01e06150g	some similarities with uniprot|Q01684 Saccharomyces cerevisiae YER115C SPR6 Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
LALA0_S01e06172g	similar to uniprot|P38177 Saccharomyces cerevisiae YBL086C Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
LALA0_S01e06194g	similar to uniprot|C5DE44 Lachancea thermotolerans KLTH0C06160g hypothetical protein
LALA0_S01e06216g	similar to uniprot|P39969 Saccharomyces cerevisiae YER114C (ohnolog of YBL085W) BOI2 Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
LALA0_S01e06238g	similar to uniprot|P38042 Saccharomyces cerevisiae YBL084C CDC27 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
LALA0_S01e06260g	similar to uniprot|P40071 Saccharomyces cerevisiae YER113C TMN3 Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
LALA0_S01e06282g	similar to uniprot|P40070 Saccharomyces cerevisiae YER112W LSM4 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
LALA0_S01e06304g	weakly similar to uniprot|P25302 Saccharomyces cerevisiae YER111C SWI4 DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
LALA0_S01e06326g	highly similar to uniprot|P40069 Saccharomyces cerevisiae YER110C KAP123 Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
LALA0_S01e06348g	similar to uniprot|P38179 Saccharomyces cerevisiae YBL082C ALG3 Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
LALA0_S01e06370g	weakly similar to uniprot|P40068 Saccharomyces cerevisiae YER109C FLO8 Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
LALA0_S01e06392g	highly similar to uniprot|P40066 Saccharomyces cerevisiae YER107C GLE2 Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p
LALA0_S01e06414g	weakly similar to uniprot|P38180 Saccharomyces cerevisiae YBL081W Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
LALA0_S01e06436g	similar to uniprot|P33893 Saccharomyces cerevisiae YBL080C PET112 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog
LALA0_S01e06458g	weakly similar to uniprot|P40065 Saccharomyces cerevisiae YER106W MAM1 Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
LALA0_S01e06480g	similar to uniprot|P40064 Saccharomyces cerevisiae YER105C (ohnolog of YBL079W) NUP157 Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly
LALA0_S01e06502g	highly similar to uniprot|P38182 Saccharomyces cerevisiae YBL078C ATG8 Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation
LALA0_S01e06524g	weakly similar to uniprot|P40063 Saccharomyces cerevisiae YER104W RTT105 Protein with a role in regulation of Ty1 transposition
LALA0_S01e06546g	highly similar to uniprot|P09436 Saccharomyces cerevisiae YBL076C ILS1 Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
LALA0_S01e06568g	highly similar to uniprot|P22202 Saccharomyces cerevisiae YER103W (ohnolog of YBL075C) SSA4 Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
LALA0_S01e06590g	similar to uniprot|P32357 Saccharomyces cerevisiae YBL074C AAR2 Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron
LALA0_S01e06612g	highly similar to uniprot|P05754 Saccharomyces cerevisiae YER102W (ohnolog of YBL072C) RPS8B Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
LALA0_S01e06634g	highly similar to uniprot|Q3E840 Saccharomyces cerevisiae YBL071W-A KTI11 Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs
LALA0_S01e06656g	similar to uniprot|P39945 Saccharomyces cerevisiae YER101C (ohnolog of YBL069W) AST2 Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
LALA0_S01e06678g	similar to uniprot|P33296 Saccharomyces cerevisiae YER100W UBC6 Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway
LALA0_S01e06700g	highly similar to uniprot|P38620 Saccharomyces cerevisiae YER099C (ohnolog of YBL068W) PRS2 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
LALA0_S01e06722g	similar to uniprot|P39967 Saccharomyces cerevisiae YER098W (ohnolog of YBL067C) UBP9 Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
LALA0_S01e06766g	similar to uniprot|P34228 Saccharomyces cerevisiae YBL066C SEF1 Putative transcription factor, has homolog in Kluyveromyces lactis
LALA0_S01e06788g	similar to uniprot|P34227 Saccharomyces cerevisiae YBL064C PRX1 Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated
LALA0_S01e06810g	similar to uniprot|P39000 Saccharomyces cerevisiae YER096W (ohnolog of YBL061C) SHC1 Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
LALA0_S01e06832g	highly similar to uniprot|P25454 Saccharomyces cerevisiae YER095W RAD51 Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
LALA0_S01e06854g	weakly similar to uniprot|P34225 Saccharomyces cerevisiae YBL060W YEL1 Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip
LALA0_S01e06876g	highly similar to uniprot|P25451 Saccharomyces cerevisiae YER094C PUP3 Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
LALA0_S01e06898g	similar to uniprot|Q3E7A4 Saccharomyces cerevisiae YBL059C-A CMC2 Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold
LALA0_S01e06920g	similar to uniprot|P87275 Saccharomyces cerevisiae YER093C-A (ohnolog of YBL059W) AIM11 Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron
LALA0_S01e06942g	similar to uniprot|P40061 Saccharomyces cerevisiae YER093C TSC11 Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain
LALA0_S01e06964g	similar to uniprot|P40060 Saccharomyces cerevisiae YER092W IES5 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
LALA0_S01e06986g	highly similar to uniprot|P05694 Saccharomyces cerevisiae YER091C MET6 Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
LALA0_S01e07008g	similar to uniprot|P34223 Saccharomyces cerevisiae YBL058W SHP1 UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate
LALA0_S01e07030g	similar to uniprot|P34222 Saccharomyces cerevisiae YBL057C PTH2 One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth
LALA0_S01e07052g	highly similar to uniprot|P00899 Saccharomyces cerevisiae YER090W TRP2 Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
LALA0_S01e07074g	highly similar to uniprot|Q06405 Saccharomyces cerevisiae YDR377W ATP17 Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
LALA0_S01e07096g	similar to uniprot|Q06406 Saccharomyces cerevisiae YDR378C LSM6 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
LALA0_S01e07118g	similar to uniprot|Q06407 Saccharomyces cerevisiae YDR379W (ohnolog of YOR127W) RGA2 GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p
LALA0_S01e07140g	highly similar to uniprot|Q3E785 Saccharomyces cerevisiae YDR379C-A Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy
LALA0_S01e07162g	similar to uniprot|C5DJD5 Lachancea thermotolerans KLTH0F15554g hypothetical protein
LALA0_S01e07184g	weakly similar to uniprot|P32862 Saccharomyces cerevisiae YKL038W (ohnolog of YBR033W EDS1) RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
LALA0_S01e07206g	highly similar to uniprot|P21264 Saccharomyces cerevisiae YOR128C ADE2 Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine
LALA0_S01e07228g	similar to uniprot|Q06408 Saccharomyces cerevisiae YDR380W ARO10 Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
LALA0_S01e07250g	weakly similar to uniprot|Q92274 Saccharomyces cerevisiae YOR129C AFI1 Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p
LALA0_S01e07272g	similar to uniprot|Q12159 Saccharomyces cerevisiae YDR381W YRA1 RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
LALA0_S01e07294g	similar to uniprot|Q3E6R5 Saccharomyces cerevisiae YDR381C-A Protein of unknown function, localized to the mitochondrial outer membrane
LALA0_S01e07316g	weakly similar to uniprot|P40556 Saccharomyces cerevisiae YIL006W (ohnolog of YEL006W) YIA6 Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs
LALA0_S01e07338g	similar to uniprot|Q12375 Saccharomyces cerevisiae YOR130C ORT1 Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
LALA0_S01e07360g	highly similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
LALA0_S01e07382g	similar to uniprot|Q12493 Saccharomyces cerevisiae YDR383C NKP1 Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p- Nkp1p-Nkp2p-Ame1p-Mtw1p)
LALA0_S01e07426g	similar to uniprot|Q12359 Saccharomyces cerevisiae YDR384C ATO3 Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
LALA0_S01e07448g	similar to uniprot|Q12486 Saccharomyces cerevisiae YOR131C Putative protein of unknown function; non-essential gene; overexpression causes a cell cycle delay or arrest
LALA0_S01e07470g	similar to uniprot|P32913 Saccharomyces cerevisiae YOR132W VPS17 Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation
LALA0_S01e07492g	highly similar to uniprot|P32324 Saccharomyces cerevisiae YDR385W (ohnolog of YOR133W) EFT2 Elongationfactor 2 (EF-2), also encoded by EFT1; catalyzes ribosomaltranslocation during protein synthesis; containsdiphthamide, the unique posttranslationally modifiedhistidine residue specifically ADP-ribosylated bydiphtheria toxin
LALA0_S01e07514g	similar to uniprot|Q04149 Saccharomyces cerevisiae YDR386W MUS81 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein
LALA0_S01e07536g	similar to uniprot|Q04162 Saccharomyces cerevisiae YDR387C Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
LALA0_S01e07558g	similar to uniprot|P39743 Saccharomyces cerevisiae YDR388W RVS167 Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin
LALA0_S01e07580g	similar to uniprot|P17121 Saccharomyces cerevisiae YDR389W (ohnolog of YOR134W) SAC7 GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
LALA0_S01e07602g	similar to uniprot|P52488 Saccharomyces cerevisiae YDR390C UBA2 Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
LALA0_S01e07624g	highly similar to uniprot|P28241 Saccharomyces cerevisiae YOR136W IDH2 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
LALA0_S01e07646g	similar to uniprot|Q12242 Saccharomyces cerevisiae YOR138C RUP1 Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain
LALA0_S01e07668g	weakly similar to uniprot|P20134 Saccharomyces cerevisiae YOR140W SFL1 Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
LALA0_S01e07690g	similar to uniprot|Q12386 Saccharomyces cerevisiae YOR141C ARP8 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
LALA0_S01e07712g	weakly similar to uniprot|Q06524 Saccharomyces cerevisiae YPR151C SUE1 Mitochondrial protein required for degradation of unstable forms of cytochrome c
LALA0_S01e07734g	weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C (ohnolog of YER057C) MMF1 Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
LALA0_S01e07756g	similar to uniprot|P29340 Saccharomyces cerevisiae YGR133W PEX4 Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
LALA0_S01e07778g	highly similar to uniprot|P40961 Saccharomyces cerevisiae YGR132C PHB1 Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
LALA0_S01e07800g	similar to uniprot|P53279 Saccharomyces cerevisiae YGR131W (ohnolog of YPR149W) FHN1 Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain
LALA0_S01e07822g	weakly similar to uniprot|P53278 Saccharomyces cerevisiae YGR130C Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
LALA0_S01e07844g	similar to uniprot|Q06523 Saccharomyces cerevisiae YPR148C Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S01e07866g	similar to uniprot|P53277 Saccharomyces cerevisiae YGR129W SYF2 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest
LALA0_S01e07888g	similar to uniprot|P53276 Saccharomyces cerevisiae YGR128C UTP8 Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
LALA0_S01e07910g	similar to uniprot|Q06522 Saccharomyces cerevisiae YPR147C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
LALA0_S01e07932g	weakly similar to uniprot|P53274 Saccharomyces cerevisiae YGR126W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
LALA0_S01e07954g	similar to uniprot|P53273 Saccharomyces cerevisiae YGR125W Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
LALA0_S01e07976g	hypothetical protein
LALA0_S01e07998g	highly similar to uniprot|P49090 Saccharomyces cerevisiae YGR124W (ohnolog of YPR145W) ASN2 Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
LALA0_S01e08020g	similar to uniprot|Q06512 Saccharomyces cerevisiae YPR144C NOC4 Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
LALA0_S01e08064g	highly similar to uniprot|P53043 Saccharomyces cerevisiae YGR123C PPT1 Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
LALA0_S01e08086g	similar to uniprot|Q06511 Saccharomyces cerevisiae YPR143W RRP15 Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
LALA0_S01e08108g	similar to uniprot|P17119 Saccharomyces cerevisiae YPR141C KAR3 Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate
LALA0_S01e08130g	similar to uniprot|Q6B2J1 Saccharomyces cerevisiae YPR140W TAZ1 Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome
LALA0_S01e08152g	similar to uniprot|Q06508 Saccharomyces cerevisiae YPR139C VPS66 Cytoplasmic protein of unknown function involved in vacuolar protein sorting
LALA0_S01e08174g	weakly similar to uniprot|P53272 Saccharomyces cerevisiae YGR122W Probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic
LALA0_S01e08196g	highly similar to uniprot|P40260 Saccharomyces cerevisiae YGR121C (ohnolog of YPR138C) MEP1 Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
LALA0_S01e08262g	hypothetical protein
LALA0_S01e08284g	highly similar to uniprot|Q06506 Saccharomyces cerevisiae YPR137W RRP9 Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
LALA0_S01e08306g	similar to uniprot|Q01454 Saccharomyces cerevisiae YPR135W CTF4 Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
LALA0_S01e08328g	similar to uniprot|P53271 Saccharomyces cerevisiae YGR120C COG2 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
LALA0_S01e08350g	similar to uniprot|P48837 Saccharomyces cerevisiae YGR119C NUP57 Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p
LALA0_S01e08372g	weakly similar to uniprot|P08593 Saccharomyces cerevisiae YPR134W MSS18 Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions
LALA0_S01e08394g	highly similar to uniprot|P80967 Saccharomyces cerevisiae YPR133W-A TOM5 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
LALA0_S01e08416g	similar to uniprot|Q06505 Saccharomyces cerevisiae YPR133C SPN1 Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype
LALA0_S01e08438g	highly similar to uniprot|P0CX29 Saccharomyces cerevisiae YGR118W (ohnolog of YPR132W) RPS23A Ribosomalprotein 28 (rp28) of the small (40S) ribosomal subunit,required for translational accuracy; nearly identical toRps23Bp and similar to E. coli S12 and rat S23 ribosomalproteins; deletion of both RPS23A and RPS23B is lethal
LALA0_S01e08460g	similar to uniprot|P53270 Saccharomyces cerevisiae YGR117C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S01e08482g	highly similar to uniprot|Q06504 Saccharomyces cerevisiae YPR131C NAT3 Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
LALA0_S01e08504g	similar to uniprot|P45978 Saccharomyces cerevisiae YPR129W SCD6 Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1
LALA0_S01e08526g	similar to uniprot|Q06497 Saccharomyces cerevisiae YPR128C ANT1 Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
LALA0_S01e08548g	similar to uniprot|P89103 Saccharomyces cerevisiae YPR125W YLH47 Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome
LALA0_S01e08570g	some similarities with uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
LALA0_S01e08592g	highly similar to uniprot|P23615 Saccharomyces cerevisiae YGR116W SPT6 Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
LALA0_S01e08614g	similar to uniprot|P49573 Saccharomyces cerevisiae YPR124W CTR1 High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels
LALA0_S01e08636g	similar to uniprot|P53267 Saccharomyces cerevisiae YGR113W DAM1 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
LALA0_S01e08658g	similar to uniprot|P53266 Saccharomyces cerevisiae YGR112W SHY1 Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
LALA0_S01e08680g	highly similar to uniprot|P33759 Saccharomyces cerevisiae YBR251W MRPS5 Mitochondrial ribosomal protein of the small subunit
LALA0_S01e08702g	some similarities with uniprot|P25042 Saccharomyces cerevisiae YPR065W ROX1 Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
LALA0_S01e08724g	similar to uniprot|P39925 Saccharomyces cerevisiae YER017C AFG3 Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
LALA0_S01e08746g	similar to uniprot|P40013 Saccharomyces cerevisiae YER016W BIM1 Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
LALA0_S01e08768g	weakly similar to uniprot|P22148 Saccharomyces cerevisiae YOL116W MSN1 Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus
LALA0_S01e08790g	similar to uniprot|P39518 Saccharomyces cerevisiae YER015W FAA2 Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome
LALA0_S01e08812g	similar to uniprot|P40567 Saccharomyces cerevisiae YIR009W MSL1 U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members
LALA0_S01e08834g	similar to uniprot|P40012 Saccharomyces cerevisiae YER014W HEM14 Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides
LALA0_S01e08856g	similar to uniprot|P24384 Saccharomyces cerevisiae YER013W PRP22 DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
LALA0_S01e08878g	highly similar to uniprot|P22141 Saccharomyces cerevisiae YER012W PRE1 Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
LALA0_S01e08900g	highly similar to uniprot|P10363 Saccharomyces cerevisiae YIR008C PRI1 Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
LALA0_S01e08922g	similar to uniprot|P40566 Saccharomyces cerevisiae YIR007W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
LALA0_S01e08944g	similar to uniprot|P40586 Saccharomyces cerevisiae YIR042C Putative protein of unknown function; YIR042C is a non-essential gene
LALA0_S01e08966g	similar to uniprot|Q08179 Saccharomyces cerevisiae YOL027C MDM38 Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome
LALA0_S01e08988g	weakly similar to uniprot|P40570 Saccharomyces cerevisiae YIR014W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
LALA0_S01e09010g	similar to uniprot|P40571 Saccharomyces cerevisiae YIR015W RPR2 Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits
LALA0_S01e09032g	weakly similar to uniprot|Q08176 Saccharomyces cerevisiae YOL026C MIM1 Mitochondrial outer membrane protein, involved in the insertion of TOM (translocase of outer membrane) complex components into the membrane and required for assembly of the TOM complex; mutants display impaired mitochondrial protein import
LALA0_S01e09054g	highly similar to uniprot|P40303 Saccharomyces cerevisiae YOL038W PRE6 Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
LALA0_S01e09076g	weakly similar to uniprot|P53063 Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
LALA0_S01e09098g	weakly similar to uniprot|P40572 Saccharomyces cerevisiae YIR016W (ohnolog of YOL036W) Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; YIR016W is a non-essential gene
LALA0_S01e09120g	some similarities with uniprot|P40573 Saccharomyces cerevisiae YIR017C MET28 Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
LALA0_S01e09164g	similar to uniprot|P40549 Saccharomyces cerevisiae YIL014W MNT3 Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
LALA0_S01e09186g	similar to uniprot|P32521 Saccharomyces cerevisiae YIR006C PAN1 Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease
LALA0_S01e09208g	similar to uniprot|P40565 Saccharomyces cerevisiae YIR005W IST3 Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
LALA0_S01e09230g	similar to uniprot|P40011 Saccharomyces cerevisiae YER010C Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
LALA0_S01e09252g	similar to uniprot|P40564 Saccharomyces cerevisiae YIR004W DJP1 Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
LALA0_S01e09274g	weakly similar to uniprot|P40563 Saccharomyces cerevisiae YIR003W AIM21 Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton
LALA0_S01e09296g	highly similar to uniprot|P33331 Saccharomyces cerevisiae YER009W NTF2 Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
LALA0_S01e09318g	similar to uniprot|P33332 Saccharomyces cerevisiae YER008C SEC3 Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion
LALA0_S01e09340g	similar to uniprot|P40562 Saccharomyces cerevisiae YIR002C MPH1 Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, binds to flap DNA and stimulates activity of Rad27p and Dna2p; mutations confer a mutator phenotype
LALA0_S01e09384g	highly similar to uniprot|P89886 Saccharomyces cerevisiae YER007C-A TMA20 Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1
LALA0_S01e09406g	similar to uniprot|P39937 Saccharomyces cerevisiae YER007W PAC2 Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
LALA0_S01e09428g	highly similar to uniprot|P40010 Saccharomyces cerevisiae YER006W NUG1 GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
LALA0_S01e09450g	similar to uniprot|P29055 Saccharomyces cerevisiae YPR086W SUA7 Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
LALA0_S01e09472g	similar to uniprot|P40009 Saccharomyces cerevisiae YER005W YND1 Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
LALA0_S01e09494g	similar to Lachancea thermotolerans KLTH0F12980g hypothetical protein
LALA0_S01e09516g	highly similar to uniprot|P29952 Saccharomyces cerevisiae YER003C PMI40 Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
LALA0_S01e09538g	similar to uniprot|P40007 Saccharomyces cerevisiae YER002W NOP16 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
LALA0_S01e09560g	some similarities with uniprot|P40561 Saccharomyces cerevisiae YIR001C SGN1 Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
LALA0_S01e09604g	weakly similar to uniprot|P40006 Saccharomyces cerevisiae YEL001C IRC22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
LALA0_S01e09626g	similar to uniprot|P40560 Saccharomyces cerevisiae YIL001W Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm
LALA0_S01e09648g	similar to uniprot|P40559 Saccharomyces cerevisiae YIL002C INP51 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth
LALA0_S01e09670g	weakly similar to uniprot|C5DF88 Lachancea thermotolerans KLTH0D13134g hypothetical protein
LALA0_S01e09692g	similar to uniprot|P33767 Saccharomyces cerevisiae YEL002C WBP1 Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum
LALA0_S01e09714g	highly similar to uniprot|P40005 Saccharomyces cerevisiae YEL003W GIM4 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
LALA0_S01e09736g	weakly similar to uniprot|P40003 Saccharomyces cerevisiae YEL005C VAB2 Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter
LALA0_S01e09758g	similar to uniprot|P40558 Saccharomyces cerevisiae YIL003W CFD1 Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
LALA0_S01e09780g	similar to uniprot|P22804 Saccharomyces cerevisiae YIL004C BET1 Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
LALA0_S01e09802g	similar to uniprot|P40557 Saccharomyces cerevisiae YIL005W EPS1 ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family
LALA0_S01e09824g	similar to uniprot|P40556 Saccharomyces cerevisiae YIL006W (ohnolog of YEL006W) YIA6 Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs
LALA0_S01e09846g	similar to uniprot|P03069 Saccharomyces cerevisiae YEL009C GCN4 Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
LALA0_S01e09868g	similar to uniprot|P40555 Saccharomyces cerevisiae YIL007C NAS2 Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p
LALA0_S01e09890g	highly similar to uniprot|P40554 Saccharomyces cerevisiae YIL008W URM1 Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response
LALA0_S01e09978g	similar to uniprot|Q03096 Saccharomyces cerevisiae YIL009C-A EST3 Component of the telomerase holoenzyme, involved in telomere replication
LALA0_S01e10000g	highly similar to uniprot|Q00776 Saccharomyces cerevisiae YPL259C APM1 Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
LALA0_S01e10022g	some similarities with uniprot|P40553 Saccharomyces cerevisiae YIL010W DOT5 Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
LALA0_S01e10044g	similar to uniprot|Q08977 Saccharomyces cerevisiae YPL260W Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene
LALA0_S01e10066g	similar to uniprot|P54867 Saccharomyces cerevisiae YOR008C SLG1 Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
LALA0_S01e10088g	weakly similar to uniprot|P40574 Saccharomyces cerevisiae YIR018W (ohnolog of YOL028C) YAP5 Basic leucine zipper (bZIP) transcription factor
LALA0_S01e10110g	similar to uniprot|Q08193 Saccharomyces cerevisiae YOL030W GAS5 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
LALA0_S01e10176g	similar to uniprot|Q03677 Saccharomyces cerevisiae YMR009W ADI1 Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
LALA0_S01e10198g	similar to uniprot|Q03687 Saccharomyces cerevisiae YMR010W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1
LALA0_S01e10220g	similar to uniprot|P32606 Saccharomyces cerevisiae YOR017W PET127 Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane
LALA0_S01e10242g	similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C AIM17 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
LALA0_S01e10264g	weakly similar to uniprot|P23179 Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
LALA0_S01e10308g	highly similar to uniprot|P39704 Saccharomyces cerevisiae YAL007C (ohnolog of YOR016C) ERP2 Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
LALA0_S01e10330g	highly similar to uniprot|Q06103 Saccharomyces cerevisiae YPR108W RPN7 Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits
LALA0_S01e10352g	highly similar to uniprot|P06115 Saccharomyces cerevisiae YGR088W CTT1 Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
LALA0_S01e10396g	similar to uniprot|Q06698 Saccharomyces cerevisiae YLR419W Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene
LALA0_S01e10418g	highly similar to uniprot|P50623 Saccharomyces cerevisiae YDL064W UBC9 SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)
LALA0_S01e10440g	similar to uniprot|Q7LGT0 Saccharomyces cerevisiae YDL063C Protein required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
LALA0_S01e10462g	weakly similar to uniprot|Q06011 Saccharomyces cerevisiae YLR390W ECM19 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S01e10484g	similar to uniprot|Q06010 Saccharomyces cerevisiae YLR389C STE23 Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family
LALA0_S01e10506g	highly similar to uniprot|P41058 Saccharomyces cerevisiae YDL061C (ohnolog of YLR388W) RPS29B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins
LALA0_S01e10528g	similar to uniprot|Q03128 Saccharomyces cerevisiae YDL060W TSR1 Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p
LALA0_S01e10550g	similar to uniprot|Q7LIF0 Saccharomyces cerevisiae YLR387C REH1 Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains
LALA0_S01e10572g	similar to uniprot|Q06708 Saccharomyces cerevisiae YLR386W VAC14 Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p
LALA0_S01e10594g	similar to uniprot|Q06707 Saccharomyces cerevisiae YLR385C SWC7 Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin
LALA0_S01e10616g	similar to uniprot|Q06706 Saccharomyces cerevisiae YLR384C IKI3 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
LALA0_S01e10638g	similar to uniprot|Q12223 Saccharomyces cerevisiae YDL059C RAD59 Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p
LALA0_S01e10660g	similar to uniprot|P25386 Saccharomyces cerevisiae YDL058W USO1 Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
LALA0_S01e10682g	similar to uniprot|Q12749 Saccharomyces cerevisiae YLR383W SMC6 Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18
LALA0_S01e10704g	similar to uniprot|P11325 Saccharomyces cerevisiae YLR382C NAM2 Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
LALA0_S01e10726g	weakly similar to uniprot|Q7LHY6 Saccharomyces cerevisiae YLR381W CTF3 Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules
LALA0_S01e10748g	similar to uniprot|Q6B265 Saccharomyces cerevisiae YLR380W CSR1 Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance
LALA0_S01e10770g	some similarities with uniprot|Q07379 Saccharomyces cerevisiae YDL057W Putative protein of unknown function; YDL057W is not an essential gene
LALA0_S01e10792g	similar to uniprot|P39678 Saccharomyces cerevisiae YDL056W MBP1 Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
LALA0_S01e10814g	highly similar to uniprot|P41940 Saccharomyces cerevisiae YDL055C PSA1 GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
LALA0_S01e10836g	similar to uniprot|P38196 Saccharomyces cerevisiae YBL042C FUI1 High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport
LALA0_S01e10880g	highly similar to uniprot|P32915 Saccharomyces cerevisiae YLR378C SEC61 Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
LALA0_S01e10902g	similar to uniprot|Q07376 Saccharomyces cerevisiae YDL054C MCH1 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
LALA0_S01e10924g	weakly similar to uniprot|Q07362 Saccharomyces cerevisiae YDL053C PBP4 Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay
LALA0_S01e10946g	highly similar to uniprot|P09201 Saccharomyces cerevisiae YLR377C FBP1 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p
LALA0_S01e10968g	similar to uniprot|P33333 Saccharomyces cerevisiae YDL052C SLC1 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
LALA0_S01e10990g	similar to uniprot|Q12318 Saccharomyces cerevisiae YLR376C PSY3 Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair; deletion results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
LALA0_S01e11012g	similar to uniprot|P33399 Saccharomyces cerevisiae YDL051W LHP1 RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
LALA0_S01e11034g	similar to uniprot|P50112 Saccharomyces cerevisiae YDL049C KNH1 Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
LALA0_S01e11056g	similar to Lachancea thermotolerans KLTH0D13640g hypothetical protein
LALA0_S01e11078g	hypothetical protein
LALA0_S01e11100g	weakly similar to uniprot|Q7LH06 Saccharomyces cerevisiae YDL048C (ohnolog of YLR375W) STP4 Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
LALA0_S01e11122g	similar to uniprot|P40319 Saccharomyces cerevisiae YLR372W SUR4 Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
LALA0_S01e11144g	similar to uniprot|P53046 Saccharomyces cerevisiae YGR070W (ohnolog of YLR371W) ROM1 GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
LALA0_S01e11166g	highly similar to uniprot|Q05933 Saccharomyces cerevisiae YLR370C ARC18 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
LALA0_S01e11188g	highly similar to uniprot|Q05931 Saccharomyces cerevisiae YLR369W SSQ1 Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia
LALA0_S01e11210g	weakly similar to uniprot|Q05930 Saccharomyces cerevisiae YLR368W MDM30 F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains
LALA0_S01e11232g	weakly similar to uniprot|P53244 Saccharomyces cerevisiae YGR068C ART5 Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane
LALA0_S01e11254g	highly similar to uniprot|P0C0W1 Saccharomyces cerevisiae YJL190C RPS22A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
LALA0_S01e11276g	highly similar to uniprot|P53241 Saccharomyces cerevisiae YGR065C VHT1 High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
LALA0_S01e11298g	similar to uniprot|Q05926 Saccharomyces cerevisiae YLR364W GRX8 Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic
LALA0_S01e11320g	highly similar to uniprot|P32914 Saccharomyces cerevisiae YGR063C SPT4 Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p
LALA0_S01e11342g	similar to uniprot|P53239 Saccharomyces cerevisiae YGR062C COX18 Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC
LALA0_S01e11364g	highly similar to uniprot|Q3E747 Saccharomyces cerevisiae YLR363W-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
LALA0_S01e11386g	highly similar to uniprot|P38972 Saccharomyces cerevisiae YGR061C ADE6 Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
LALA0_S01e11408g	highly similar to uniprot|P53045 Saccharomyces cerevisiae YGR060W ERG25 C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
LALA0_S01e11430g	similar to uniprot|Q12129 Saccharomyces cerevisiae YLR363C NMD4 Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway
LALA0_S01e11452g	similar to uniprot|P53238 Saccharomyces cerevisiae YGR058W PEF1 Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2
LALA0_S01e11474g	highly similar to uniprot|Q08745 Saccharomyces cerevisiae YOR293W (ohnolog of YMR230W) RPS10A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
LALA0_S01e11496g	similar to uniprot|Q08743 Saccharomyces cerevisiae YOR292C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
LALA0_S01e11518g	similar to uniprot|Q12697 Saccharomyces cerevisiae YOR291W YPK9 Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
LALA0_S01e11540g	similar to uniprot|Q05022 Saccharomyces cerevisiae YMR229C RRP5 RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome
LALA0_S01e11562g	weakly similar to Lachancea thermotolerans KLTH0D13068g hypothetical protein
LALA0_S01e11584g	similar to uniprot|P14908 Saccharomyces cerevisiae YMR228W MTF1 Mitochondrial RNA polymerase specificityfactor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity tobacterial sigma-factors, interacts with mitochondrial corepolymerase Rpo41p
LALA0_S01e11606g	similar to uniprot|Q05021 Saccharomyces cerevisiae YMR227C TAF7 TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
LALA0_S01e11628g	similar to uniprot|E4ZYE5 Leptosphaeria maculans LEMA_P113090.1 hypothetical protein
LALA0_S01e11650g	similar to uniprot|P22082 Saccharomyces cerevisiae YOR290C SNF2 Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
LALA0_S01e11672g	highly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
LALA0_S01e11738g	similar to uniprot|P25377 Saccharomyces cerevisiae YCR105W ADH7 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
LALA0_S01e11760g	highly similar to uniprot|P05030 Saccharomyces cerevisiae YGL008C PMA1 Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
LALA0_S01e11804g	highly similar to uniprot|Q03558 Saccharomyces cerevisiae YHR179W OYE2 Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death
LALA0_S01e11826g	similar to uniprot|P25339 Saccharomyces cerevisiae YGL014W PUF4 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
LALA0_S01e11848g	weakly similar to uniprot|P12383 Saccharomyces cerevisiae YGL013C (ohnolog of YBL005W) PDR1 Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes
LALA0_S01e11870g	highly similar to uniprot|P25340 Saccharomyces cerevisiae YGL012W ERG4 C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
LALA0_S01e11892g	similar to uniprot|P38210 Saccharomyces cerevisiae YBL006C LDB7 Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
LALA0_S01e11914g	highly similar to uniprot|P21243 Saccharomyces cerevisiae YGL011C SCL1 Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
LALA0_S01e11936g	similar to uniprot|P25338 Saccharomyces cerevisiae YGL010W Putative protein of unknown function; YGL010W is not an essential gene
LALA0_S01e11958g	similar to uniprot|P32790 Saccharomyces cerevisiae YBL007C SLA1 Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
LALA0_S01e11980g	highly similar to uniprot|P07264 Saccharomyces cerevisiae YGL009C LEU1 Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
LALA0_S01e12002g	similar to uniprot|P32479 Saccharomyces cerevisiae YBL008W HIR1 Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
LALA0_S01e12024g	similar to uniprot|P32767 Saccharomyces cerevisiae YGL016W KAP122 Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance
LALA0_S01e12046g	similar to uniprot|P16639 Saccharomyces cerevisiae YGL017W ATE1 Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
LALA0_S01e12068g	similar to uniprot|P53193 Saccharomyces cerevisiae YGL018C JAC1 Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
LALA0_S01e12090g	highly similar to uniprot|P43639 Saccharomyces cerevisiae YGL019W CKB1 Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
LALA0_S01e12112g	weakly similar to uniprot|P53192 Saccharomyces cerevisiae YGL020C GET1 Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
LALA0_S01e12134g	weakly similar to uniprot|P43633 Saccharomyces cerevisiae YGL021W (ohnolog of YBL009W) ALK1 Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins
LALA0_S01e12156g	weakly similar to uniprot|P32788 Saccharomyces cerevisiae YBL010C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
LALA0_S01e12178g	highly similar to uniprot|P39007 Saccharomyces cerevisiae YGL022W STT3 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis
LALA0_S01e12200g	weakly similar to uniprot|P53191 Saccharomyces cerevisiae YGL023C PIB2 Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27
LALA0_S01e12222g	similar to uniprot|P32784 Saccharomyces cerevisiae YBL011W SCT1 Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
LALA0_S01e12266g	similar to uniprot|P32785 Saccharomyces cerevisiae YBL013W FMT1 Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate
LALA0_S01e12288g	weakly similar to uniprot|P40356 Saccharomyces cerevisiae YGL025C PGD1 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
LALA0_S01e12310g	highly similar to uniprot|P00931 Saccharomyces cerevisiae YGL026C TRP5 Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
LALA0_S01e12332g	weakly similar to uniprot|P32786 Saccharomyces cerevisiae YBL014C RRN6 Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
LALA0_S01e12354g	similar to uniprot|P53008 Saccharomyces cerevisiae YGL027C CWH41 Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
LALA0_S01e12376g	similar to uniprot|P53189 Saccharomyces cerevisiae YGL028C SCW11 Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
LALA0_S01e12398g	highly similar to uniprot|C5DHU1 Lachancea thermotolerans KLTH0E07106g hypothetical protein
LALA0_S01e12442g	similar to uniprot|P53188 Saccharomyces cerevisiae YGL029W CGR1 Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
LALA0_S01e12464g	similar to uniprot|P48237 Saccharomyces cerevisiae YGR150C CCM1 Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
LALA0_S01e12486g	similar to uniprot|P48236 Saccharomyces cerevisiae YGR149W Putative protein of unknown function; predicted to be an integal membrane protein
LALA0_S01e12508g	weakly similar to uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
LALA0_S01e12530g	similar to uniprot|P32350 Saccharomyces cerevisiae YLL019C KNS1 Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
LALA0_S01e12552g	weakly similar to Lachancea thermotolerans KLTH0E06666g hypothetical protein
LALA0_S01e12574g	similar to uniprot|Q02199 Saccharomyces cerevisiae YGL172W NUP49 Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes
LALA0_S01e12596g	similar to uniprot|P22147 Saccharomyces cerevisiae YGL173C KEM1 Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
LALA0_S01e12618g	similar to uniprot|P46947 Saccharomyces cerevisiae YGL174W BUD13 Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern
LALA0_S01e12640g	weakly similar to uniprot|P46946 Saccharomyces cerevisiae YGL175C SAE2 Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
LALA0_S01e12662g	similar to uniprot|Q12482 Saccharomyces cerevisiae YPR021C AGC1 Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis
LALA0_S01e12684g	similar to uniprot|Q12432 Saccharomyces cerevisiae YPR023C EAF3 Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
LALA0_S01e12706g	similar to uniprot|P39962 Saccharomyces cerevisiae YER123W YCK3 Palmitoylated, vacuolar membrane-localizedcasein kinase I isoform; negatively regulates vacuolefusion during hypertonic stress via phosphorylation ofVps41p; shares essential functions with Hrr25p; regulatesvesicle fusion in AP-3 pathway
LALA0_S01e12728g	similar to uniprot|P40077 Saccharomyces cerevisiae YER124C DSE1 Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall
LALA0_S01e12750g	highly similar to uniprot|P39940 Saccharomyces cerevisiae YER125W RSP5 E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy
LALA0_S01e12772g	weakly similar to uniprot|P46945 Saccharomyces cerevisiae YGL176C Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype
LALA0_S01e12794g	similar to uniprot|P39016 Saccharomyces cerevisiae YGL178W MPT5 Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
LALA0_S01e12816g	highly similar to uniprot|P40078 Saccharomyces cerevisiae YER126C NSA2 Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
LALA0_S01e12838g	similar to uniprot|P40079 Saccharomyces cerevisiae YER127W LCP5 Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
LALA0_S01e12860g	similar to uniprot|P40080 Saccharomyces cerevisiae YER128W Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology
LALA0_S01e12882g	weakly similar to uniprot|P43637 Saccharomyces cerevisiae YGL179C (ohnolog of YER129W) TOS3 Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
LALA0_S01e12904g	similar to uniprot|P53104 Saccharomyces cerevisiae YGL180W ATG1 Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p
LALA0_S01e12926g	weakly similar to uniprot|P40956 Saccharomyces cerevisiae YGL181W GTS1 Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
LALA0_S01e12948g	similar to uniprot|P53102 Saccharomyces cerevisiae YGL183C MND1 Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
LALA0_S01e12970g	weakly similar to uniprot|P39959 Saccharomyces cerevisiae YER130C Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; the C. Albicans homolog (MNL1) plays a role in adaptation to stress
LALA0_S01e12992g	similar to uniprot|Q754A2 Ashbya gossypii AFR170Cp hypothetical protein
LALA0_S01e13014g	similar to uniprot|P53101 Saccharomyces cerevisiae YGL184C STR3 Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p
LALA0_S01e13036g	similar to uniprot|P53100 Saccharomyces cerevisiae YGL185C Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S01e13058g	similar to uniprot|P53099 Saccharomyces cerevisiae YGL186C TPN1 Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
LALA0_S01e13080g	highly similar to uniprot|P04037 Saccharomyces cerevisiae YGL187C COX4 Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation
LALA0_S01e13102g	highly similar to uniprot|P39938 Saccharomyces cerevisiae YGL189C (ohnolog of YER131W) RPS26A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein
LALA0_S01e13124g	similar to uniprot|Q00362 Saccharomyces cerevisiae YGL190C CDC55 Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); involved in regulation of mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains sequestration of the phosphatase Cdc14p in nucleolus during early meiosis, which is essential for meiosis I spindle assembly; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; found in nucleus, bud neck and bud of most cells
LALA0_S01e13146g	highly similar to uniprot|P32799 Saccharomyces cerevisiae YGL191W COX13 Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
LALA0_S01e13190g	similar to uniprot|P41833 Saccharomyces cerevisiae YGL192W IME4 Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids
LALA0_S01e13212g	highly similar to uniprot|P53096 Saccharomyces cerevisiae YGL194C HOS2 Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity
LALA0_S01e13234g	similar to uniprot|C5DHM3 Lachancea thermotolerans KLTH0E05522g hypothetical protein
LALA0_S01e13256g	similar to uniprot|P33892 Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA
LALA0_S01e13278g	weakly similar to uniprot|P53094 Saccharomyces cerevisiae YGL197W (ohnolog of YER132C) MDS3 Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain
LALA0_S01e13300g	similar to uniprot|P53093 Saccharomyces cerevisiae YGL198W YIP4 Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
LALA0_S01e13322g	highly similar to uniprot|P32598 Saccharomyces cerevisiae YER133W GLC7 Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits
LALA0_S01e13344g	highly similar to uniprot|P32803 Saccharomyces cerevisiae YGL200C EMP24 Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
LALA0_S01e13388g	similar to uniprot|P38742 Saccharomyces cerevisiae YHL023C NPR3 Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation; subunit of SEA (Seh1-associated) complex; null mutant displays delayed meiotic DNA replication and double-strand break repair
LALA0_S01e13410g	weakly similar to uniprot|P38741 Saccharomyces cerevisiae YHL024W RIM4 Putative RNA-binding protein required for the expression of early and middle sporulation genes
LALA0_S01e13432g	similar to uniprot|P36156 Saccharomyces cerevisiae YKR076W ECM4 Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S01e13454g	highly similar to uniprot|P31539 Saccharomyces cerevisiae YLL026W HSP104 Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation
LALA0_S01e13476g	similar to uniprot|Q07821 Saccharomyces cerevisiae YLL027W ISA1 Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources
LALA0_S01e13498g	similar to uniprot|Q07825 Saccharomyces cerevisiae YLL029W FRA1 Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation
LALA0_S01e13520g	similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
LALA0_S01e13542g	similar to uniprot|Q07830 Saccharomyces cerevisiae YLL031C GPI13 ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
LALA0_S01e13564g	weakly similar to uniprot|P18888 Saccharomyces cerevisiae YHL025W SNF6 Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p
LALA0_S01e13586g	weakly similar to uniprot|Q07834 Saccharomyces cerevisiae YLL032C Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
LALA0_S01e13608g	similar to uniprot|Q07843 Saccharomyces cerevisiae YLL033W IRC19 Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
LALA0_S01e13630g	highly similar to uniprot|Q07844 Saccharomyces cerevisiae YLL034C RIX7 Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
LALA0_S01e13652g	similar to uniprot|Q9P4W6 Saccharomyces cerevisiae YLL035W GRC3 Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
LALA0_S01e13674g	weakly similar to uniprot|P33400 Saccharomyces cerevisiae YHL027W RIM101 Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC
LALA0_S01e13696g	similar to uniprot|P38739 Saccharomyces cerevisiae YHL028W WSC4 ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
LALA0_S01e13718g	similar to uniprot|P38738 Saccharomyces cerevisiae YHL029C OCA5 Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
LALA0_S01e13740g	weakly similar to uniprot|P32523 Saccharomyces cerevisiae YLL036C PRP19 Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain
LALA0_S01e13762g	similar to uniprot|Q07872 Saccharomyces cerevisiae YLL038C ENT4 Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
LALA0_S01e13784g	some similarities with uniprot|P04838 Saccharomyces cerevisiae YLL039C UBI4 Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
LALA0_S01e13806g	similar to uniprot|P38737 Saccharomyces cerevisiae YHL030W ECM29 Scaffold protein that assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats
LALA0_S01e13828g	similar to uniprot|Q07878 Saccharomyces cerevisiae YLL040C VPS13 Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention
LALA0_S01e13850g	highly similar to uniprot|P21801 Saccharomyces cerevisiae YLL041C SDH2 Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
LALA0_S01e13872g	weakly similar to uniprot|Q07879 Saccharomyces cerevisiae YLL042C ATG10 Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
LALA0_S01e13894g	similar to uniprot|P38736 Saccharomyces cerevisiae YHL031C GOS1 v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
LALA0_S01e13916g	similar to uniprot|P23900 Saccharomyces cerevisiae YLL043W FPS1 Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
LALA0_S01e13938g	similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S01e13960g	similar to uniprot|P32190 Saccharomyces cerevisiae YHL032C GUT1 Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
LALA0_S01e13982g	highly similar to uniprot|P17076 Saccharomyces cerevisiae YHL033C (ohnolog of YLL045C) RPL8A Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
LALA0_S01e14004g	similar to uniprot|P06197 Saccharomyces cerevisiae YPR113W PIS1 Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins
LALA0_S01e14026g	weakly similar to uniprot|P38113 Saccharomyces cerevisiae YBR145W (ohnolog of YOL086C) ADH5 Alcohol dehydrogenase isoenzyme V; involved in ethanol production
LALA0_S01e14048g	similar to uniprot|Q08902 Saccharomyces cerevisiae YOR378W Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
LALA0_S01e14070g	weakly similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
LALA0_S01e14092g	highly similar to uniprot|P38113 Saccharomyces cerevisiae YBR145W (ohnolog of YOL086C) ADH5 Alcoholdehydrogenase isoenzyme V; involved in ethanol production
LALA0_S01e14114g	similar to uniprot|Q06107 Saccharomyces cerevisiae YPR114W Putative protein of unknown function
LALA0_S01e14136g	similar to uniprot|P48361 Saccharomyces cerevisiae YGR097W (ohnolog of YPR115W) ASK10 Component of RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; paralogous to Rgc1p
LALA0_S01e14158g	highly similar to uniprot|Q0UMW8 Phaeosphaeria nodorum SNOG_06896 hypothetical protein
LALA0_S01e14180g	weakly similar to uniprot|Q06109 Saccharomyces cerevisiae YPR116W RRG8 Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport
LALA0_S01e14202g	similar to uniprot|Q03018 Saccharomyces cerevisiae YGR098C ESP1 Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p
LALA0_S01e14224g	similar to uniprot|P53038 Saccharomyces cerevisiae YGR099W TEL2 Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect
LALA0_S01e14246g	similar to uniprot|Q06116 Saccharomyces cerevisiae YPR117W Putative protein of unknown function
LALA0_S01e14268g	similar to uniprot|P53258 Saccharomyces cerevisiae YGR100W MDR1 Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
LALA0_S01e14290g	similar to uniprot|P53259 Saccharomyces cerevisiae YGR101W PCP1 Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
LALA0_S01e14312g	similar to uniprot|P53260 Saccharomyces cerevisiae YGR102C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
LALA0_S01e14334g	highly similar to uniprot|P53261 Saccharomyces cerevisiae YGR103W NOP7 Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation
LALA0_S01e14356g	similar to uniprot|P32585 Saccharomyces cerevisiae YGR104C SRB5 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance
LALA0_S01e14378g	similar to uniprot|P41806 Saccharomyces cerevisiae YGR105W VMA21 Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
LALA0_S01e14400g	similar to uniprot|P53262 Saccharomyces cerevisiae YGR106C VOA1 Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
LALA0_S01e14444g	similar to uniprot|Q06489 Saccharomyces cerevisiae YPR118W MRI1 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway
LALA0_S01e14466g	similar to uniprot|C5DHI4 Lachancea thermotolerans KLTH0E04576g hypothetical protein
LALA0_S01e14510g	similar to uniprot|P24868 Saccharomyces cerevisiae YGR108W (ohnolog of YPR119W) CLB1 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
LALA0_S01e14532g	similar to uniprot|P32943 Saccharomyces cerevisiae YGR109C (ohnolog of YPR120C) CLB6 B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1
LALA0_S01e14576g	similar to uniprot|P40851 Saccharomyces cerevisiae YPR122W AXL1 Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
LALA0_S01e14598g	similar to uniprot|P53265 Saccharomyces cerevisiae YGR111W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S01e14642g	highly similar to uniprot|P33317 Saccharomyces cerevisiae YBR252W DUT1 deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
LALA0_S01e14664g	similar to uniprot|P32570 Saccharomyces cerevisiae YBR253W SRB6 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
LALA0_S01e14686g	similar to uniprot|P40568 Saccharomyces cerevisiae YIR010W DSN1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
LALA0_S01e14708g	similar to uniprot|P38334 Saccharomyces cerevisiae YBR254C TRS20 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
LALA0_S01e14730g	weakly similar to uniprot|P38335 Saccharomyces cerevisiae YBR255W MTC4 Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
LALA0_S01e14752g	highly similar to uniprot|Q3E776 Saccharomyces cerevisiae YBR255C-A Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species
LALA0_S01e14774g	similar to uniprot|P38637 Saccharomyces cerevisiae YIR011C STS1 Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
LALA0_S01e14796g	similar to uniprot|P35184 Saccharomyces cerevisiae YIR012W SQT1 Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
LALA0_S01e14818g	highly similar to uniprot|P38145 Saccharomyces cerevisiae YBR256C RIB5 Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
LALA0_S01e14840g	weakly similar to uniprot|P40548 Saccharomyces cerevisiae YIL016W SNL1 Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
LALA0_S01e14862g	similar to uniprot|P40547 Saccharomyces cerevisiae YIL017C VID28 Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
LALA0_S01e14884g	similar to uniprot|P39692 Saccharomyces cerevisiae YFR030W MET10 Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
LALA0_S01e14906g	similar to uniprot|P38989 Saccharomyces cerevisiae YFR031C SMC2 Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
LALA0_S01e14928g	highly similar to uniprot|P05736 Saccharomyces cerevisiae YIL018W (ohnolog of YFR031C-A) RPL2B Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures
LALA0_S01e14950g	weakly similar to uniprot|P43607 Saccharomyces cerevisiae YFR032C RRT5 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation
LALA0_S01e14972g	highly similar to uniprot|P05747 Saccharomyces cerevisiae YFR032C-A RPL29 Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate
LALA0_S01e14994g	similar to uniprot|P00127 Saccharomyces cerevisiae YFR033C QCR6 Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
LALA0_S01e15016g	some similarities with uniprot|P07270 Saccharomyces cerevisiae YFR034C PHO4 Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability
LALA0_S01e15038g	similar to uniprot|P40546 Saccharomyces cerevisiae YIL019W FAF1 Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
LALA0_S01e15060g	highly similar to uniprot|P40545 Saccharomyces cerevisiae YIL020C HIS6 Phosphoribosyl-5-amino-1-phosphoribosyl-4- imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
LALA0_S01e15082g	highly similar to uniprot|P16370 Saccharomyces cerevisiae YIL021W RPB3 RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
LALA0_S01e15104g	similar to uniprot|B5RSJ3 Kluyveromyces lactis KLLA0B13123g hypothetical protein
LALA0_S01e15126g	highly similar to uniprot|Q01852 Saccharomyces cerevisiae YIL022W TIM44 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
LALA0_S01e15148g	weakly similar to uniprot|P40537 Saccharomyces cerevisiae YIL031W ULP2 Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate
LALA0_S01e15170g	similar to uniprot|P40318 Saccharomyces cerevisiae YIL030C SSM4 Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
LALA0_S01e15214g	weakly similar to uniprot|P14724 Saccharomyces cerevisiae YFR036W CDC26 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
LALA0_S01e15236g	similar to uniprot|P40540 Saccharomyces cerevisiae YIL027C KRE27 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance
LALA0_S01e15258g	similar to uniprot|P40541 Saccharomyces cerevisiae YIL026C IRR1 Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
LALA0_S01e15280g	weakly similar to uniprot|P40543 Saccharomyces cerevisiae YIL024C Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
LALA0_S01e15302g	weakly similar to uniprot|P40544 Saccharomyces cerevisiae YIL023C YKE4 Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
LALA0_S01e15324g	weakly similar to uniprot|Q6B1J7 Saccharomyces cerevisiae YLR360W VPS38 Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity
LALA0_S01e15346g	similar to uniprot|Q05924 Saccharomyces cerevisiae YLR361C DCR2 Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START
LALA0_S01e15368g	weakly similar to uniprot|C5DJF4 Lachancea thermotolerans KLTH0F15972g hypothetical protein
LALA0_S01e15390g	similar to uniprot|P23561 Saccharomyces cerevisiae YLR362W STE11 Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p
LALA0_S01e15412g	similar to uniprot|P12868 Saccharomyces cerevisiae YMR231W PEP5 Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p
LALA0_S01e15434g	similar to uniprot|Q05670 Saccharomyces cerevisiae YMR232W FUS2 Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating
LALA0_S01e15456g	highly similar to uniprot|Q08746 Saccharomyces cerevisiae YOR294W RRS1 Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
LALA0_S01e15478g	similar to uniprot|Q08747 Saccharomyces cerevisiae YOR295W (ohnolog of YMR233W) UAF30 Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate
LALA0_S01e15500g	similar to uniprot|Q08748 Saccharomyces cerevisiae YOR296W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
LALA0_S01e15522g	similar to uniprot|Q04740 Saccharomyces cerevisiae YMR234W RNH1 Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
LALA0_S01e15544g	similar to uniprot|Q08749 Saccharomyces cerevisiae YOR297C TIM18 Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
LALA0_S01e15566g	weakly similar to uniprot|Q08750 Saccharomyces cerevisiae YOR298W MUM3 Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases
LALA0_S01e15588g	similar to uniprot|P11745 Saccharomyces cerevisiae YMR235C RNA1 GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
LALA0_S01e15610g	highly similar to uniprot|Q86ZS7 Saccharomyces cerevisiae YOR298C-A MBF1 Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
LALA0_S01e15632g	similar to uniprot|P34220 Saccharomyces cerevisiae YBL055C 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
LALA0_S01e15654g	similar to uniprot|P39966 Saccharomyces cerevisiae YER089C (ohnolog of YBL056W) PTC2 Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint
LALA0_S01e15676g	similar to uniprot|P48360 Saccharomyces cerevisiae YDR376W ARH1 Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
LALA0_S01e15698g	highly similar to uniprot|P32839 Saccharomyces cerevisiae YDR375C BCS1 Mitochondrial protein of the AAA ATPase family; has ATP-dependent chaperone activity; required for assembly of Rip1p and Qcr10p into cytochrome bc(1) complex; mutations in human homolog BCS1L are linked to neonatal mitochondrial diseases
LALA0_S01e15720g	weakly similar to uniprot|Q06390 Saccharomyces cerevisiae YDR374C Putative protein of unknown function
LALA0_S01e15742g	similar to uniprot|P41735 Saccharomyces cerevisiae YOR125C CAT5 Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
LALA0_S01e15764g	highly similar to uniprot|Q06389 Saccharomyces cerevisiae YDR373W FRQ1 N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily
LALA0_S01e15786g	similar to uniprot|Q01476 Saccharomyces cerevisiae YOR124C UBP2 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity
LALA0_S01e15808g	highly similar to uniprot|Q06385 Saccharomyces cerevisiae YDR372C VPS74 Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; binding to PtdIns4P required for Golgi targeting and function; tetramer formation required for function
LALA0_S01e15830g	similar to uniprot|Q06350 Saccharomyces cerevisiae YDR371W CTS2 Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
LALA0_S01e15852g	similar to uniprot|P38439 Saccharomyces cerevisiae YOR123C LEO1 Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
LALA0_S01e15874g	highly similar to uniprot|P07274 Saccharomyces cerevisiae YOR122C PFY1 Profilin, binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress
LALA0_S01e15896g	similar to uniprot|G8JU42 Eremothecium cymbalariae Ecym_4508 hypothetical protein
LALA0_S01e15918g	weakly similar to uniprot|C5DJJ8 Lachancea thermotolerans KLTH0F17006g hypothetical protein
LALA0_S01e15940g	weakly similar to uniprot|Q06349 Saccharomyces cerevisiae YDR370C Putative protein of unknown function
LALA0_S01e15962g	weakly similar to uniprot|P53969 Saccharomyces cerevisiae YNL026W SAM50 Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
LALA0_S01e15984g	weakly similar to uniprot|P33301 Saccharomyces cerevisiae YDR369C XRS2 Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
LALA0_S01e16006g	similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W (ohnolog of YOR120W) YPR1 NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases
LALA0_S01e16028g	similar to uniprot|Q06999 Saccharomyces cerevisiae YDR367W KEI1 Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
LALA0_S01e16050g	highly similar to uniprot|Q12196 Saccharomyces cerevisiae YOR119C RIO1 Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
LALA0_S01e16072g	similar to uniprot|Q12108 Saccharomyces cerevisiae YOR118W RTC5 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
LALA0_S01e16094g	similar to uniprot|Q06344 Saccharomyces cerevisiae YDR365C ESF1 Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
LALA0_S01e16138g	similar to uniprot|P40968 Saccharomyces cerevisiae YDR364C CDC40 Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats
LALA0_S01e16160g	highly similar to uniprot|P33297 Saccharomyces cerevisiae YOR117W RPT5 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
LALA0_S01e16182g	similar to uniprot|O94742 Saccharomyces cerevisiae YDR363W-A SEM1 Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1
LALA0_S01e16204g	highly similar to uniprot|P04051 Saccharomyces cerevisiae YOR116C RPO31 RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
LALA0_S01e16248g	weakly similar to uniprot|Q06340 Saccharomyces cerevisiae YDR363W ESC2 Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member
LALA0_S01e16270g	similar to uniprot|P38821 Saccharomyces cerevisiae YHR113W APE4 Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family
LALA0_S01e16292g	similar to uniprot|Q06339 Saccharomyces cerevisiae YDR362C TFC6 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
LALA0_S01e16314g	highly similar to uniprot|P38820 Saccharomyces cerevisiae YHR111W UBA4 Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p
LALA0_S01e16336g	weakly similar to uniprot|P38819 Saccharomyces cerevisiae YHR110W ERP5 Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
LALA0_S01e16358g	weakly similar to uniprot|P38818 Saccharomyces cerevisiae YHR109W CTM1 Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
LALA0_S01e16380g	similar to uniprot|Q06338 Saccharomyces cerevisiae YDR361C BCP1 Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
LALA0_S01e16402g	similar to uniprot|Q06337 Saccharomyces cerevisiae YDR359C EAF1 Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1
LALA0_S01e16424g	similar to uniprot|P38817 Saccharomyces cerevisiae YHR108W (ohnolog of YDR358W) GGA2 Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
LALA0_S01e16446g	similar to uniprot|Q06333 Saccharomyces cerevisiae YDR357C CNL1 Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S01e16468g	weakly similar to uniprot|P32380 Saccharomyces cerevisiae YDR356W SPC110 Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
LALA0_S01e16490g	similar to uniprot|P07285 Saccharomyces cerevisiae YDR354W TRP4 Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
LALA0_S01e16512g	highly similar to uniprot|P32468 Saccharomyces cerevisiae YHR107C CDC12 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
LALA0_S01e16534g	highly similar to uniprot|P38816 Saccharomyces cerevisiae YHR106W (ohnolog of YDR353W) TRR2 Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD
LALA0_S01e16556g	weakly similar to uniprot|P38815 Saccharomyces cerevisiae YHR105W YPT35 Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport
LALA0_S01e16578g	highly similar to uniprot|P38715 Saccharomyces cerevisiae YHR104W GRE3 Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway
LALA0_S01e16600g	similar to uniprot|Q06328 Saccharomyces cerevisiae YDR352W Putative protein of unknown function
LALA0_S01e16622g	similar to uniprot|P38814 Saccharomyces cerevisiae YHR103W (ohnolog of YDR351W) SBE22 Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
LALA0_S01e16644g	similar to uniprot|P38692 Saccharomyces cerevisiae YHR102W KIC1 Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis
LALA0_S01e16666g	weakly similar to uniprot|P50273 Saccharomyces cerevisiae YDR350C ATP22 Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane
LALA0_S01e16688g	weakly similar to uniprot|P38813 Saccharomyces cerevisiae YHR101C BIG1 Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
LALA0_S01e16710g	similar to uniprot|P32854 Saccharomyces cerevisiae YOR036W PEP12 Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
LALA0_S01e16732g	similar to uniprot|Q05583 Saccharomyces cerevisiae YDR267C CIA1 WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene
LALA0_S01e16754g	similar to uniprot|P38909 Saccharomyces cerevisiae YOR037W CYC2 Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
LALA0_S01e16776g	similar to uniprot|P04803 Saccharomyces cerevisiae YDR268W MSW1 Mitochondrial tryptophanyl-tRNA synthetase
LALA0_S01e16798g	similar to uniprot|P32480 Saccharomyces cerevisiae YOR038C HIR2 Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
LALA0_S01e16820g	similar to uniprot|P38930 Saccharomyces cerevisiae YOR039W CKB2 Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
LALA0_S01e16842g	similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases
LALA0_S01e16864g	similar to uniprot|Q05584 Saccharomyces cerevisiae YDR272W (ohnolog of YOR040W) GLO2 Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
LALA0_S01e16886g	similar to uniprot|Q05610 Saccharomyces cerevisiae YDR273W (ohnolog of YOR042W) DON1 Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
LALA0_S01e16908g	similar to uniprot|P12611 Saccharomyces cerevisiae YOR043W WHI2 Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
LALA0_S01e16930g	weakly similar to uniprot|C5DJJ8 Lachancea thermotolerans KLTH0F17006g hypothetical protein
LALA0_S01e16952g	similar to uniprot|P33448 Saccharomyces cerevisiae YOR045W TOM6 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
LALA0_S01e16974g	highly similar to uniprot|P87284 Saccharomyces cerevisiae YDR276C PMP3 Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
LALA0_S01e16996g	highly similar to uniprot|P20449 Saccharomyces cerevisiae YOR046C DBP5 Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p
LALA0_S01e17018g	similar to uniprot|P35198 Saccharomyces cerevisiae YDR277C (ohnolog of YOR047C) MTH1 Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
LALA0_S01e17040g	hypothetical protein
LALA0_S01e17084g	weakly similar to uniprot|Q7LHG5 Saccharomyces cerevisiae YIL082W-A TY3B-I Transposon Ty3-I Gag-Pol polyprotein
LALA0_S01e17106g	similar to uniprot|Q02792 Saccharomyces cerevisiae YOR048C RAT1 Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
LALA0_S01e17128g	similar to uniprot|P36052 Saccharomyces cerevisiae YKL162C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
LALA0_S01e17150g	similar to uniprot|Q08417 Saccharomyces cerevisiae YOR049C RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
LALA0_S01e17172g	similar to uniprot|P36148 Saccharomyces cerevisiae YKR067W GPT2 Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
LALA0_S01e17194g	highly similar to uniprot|P36149 Saccharomyces cerevisiae YKR068C BET3 Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex
LALA0_S01e17216g	similar to uniprot|Q6Q5I2 Saccharomyces cerevisiae YOR051C ETT1 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
LALA0_S01e17238g	similar to uniprot|P36150 Saccharomyces cerevisiae YKR069W MET1 S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
LALA0_S01e17260g	similar to uniprot|P36151 Saccharomyces cerevisiae YKR070W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S01e17282g	similar to uniprot|O00017 Saccharomyces cerevisiae YOR052C Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic
LALA0_S01e17304g	similar to uniprot|P36152 Saccharomyces cerevisiae YKR071C DRE2 Conserved component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p; ortholog of human Ciapin1
LALA0_S01e17326g	similar to uniprot|O00019 Saccharomyces cerevisiae YOR054C (ohnolog of YKR072C) VHS3 Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis
LALA0_S01e17348g	similar to uniprot|O00021 Saccharomyces cerevisiae YOR056C NOB1 Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA
LALA0_S01e17370g	similar to uniprot|Q08446 Saccharomyces cerevisiae YOR057W SGT1 Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes
LALA0_S01e17392g	similar to uniprot|P50275 Saccharomyces cerevisiae YOR058C ASE1 Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate
LALA0_S01e17436g	similar to uniprot|P36154 Saccharomyces cerevisiae YKR074W AIM29 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S01e17458g	similar to uniprot|O00022 Saccharomyces cerevisiae YOR059C Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor RPN4
LALA0_S01e17480g	similar to uniprot|O00023 Saccharomyces cerevisiae YOR060C SLD7 Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
LALA0_S01e17502g	highly similar to uniprot|P19454 Saccharomyces cerevisiae YOR061W CKA2 Alpha' catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
LALA0_S01e17524g	weakly similar to uniprot|P36025 Saccharomyces cerevisiae YOR062C (ohnolog of YKR075C) Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
LALA0_S01e17546g	highly similar to uniprot|P14126 Saccharomyces cerevisiae YOR063W RPL3 Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
LALA0_S01e17568g	weakly similar to uniprot|O00025 Saccharomyces cerevisiae YOR064C YNG1 Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
LALA0_S01e17590g	highly similar to uniprot|P07143 Saccharomyces cerevisiae YOR065W CYT1 Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
LALA0_S01e17612g	weakly similar to uniprot|O00026 Saccharomyces cerevisiae YOR066W (ohnolog of YKR077W) MSA1 Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
LALA0_S01e17634g	similar to uniprot|P40351 Saccharomyces cerevisiae YOR067C ALG8 Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p
LALA0_S01e17656g	similar to uniprot|Q92331 Saccharomyces cerevisiae YOR069W (ohnolog of YKR078W) VPS5 Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p
LALA0_S01e17678g	similar to uniprot|P36159 Saccharomyces cerevisiae YKR079C TRZ1 tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
LALA0_S01e17700g	similar to uniprot|Q08484 Saccharomyces cerevisiae YOR070C GYP1 Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
LALA0_S01e17722g	highly similar to uniprot|Q02046 Saccharomyces cerevisiae YKR080W MTD1 NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
LALA0_S01e17744g	highly similar to uniprot|P36160 Saccharomyces cerevisiae YKR081C RPF2 Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
LALA0_S01e17766g	similar to uniprot|P36161 Saccharomyces cerevisiae YKR082W NUP133 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; required also for transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
LALA0_S01e17788g	similar to uniprot|P36162 Saccharomyces cerevisiae YKR083C DAD2 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
LALA0_S01e17810g	similar to uniprot|Q08490 Saccharomyces cerevisiae YOR073W SGO1 Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
LALA0_S01e17832g	highly similar to uniprot|P06785 Saccharomyces cerevisiae YOR074C CDC21 Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
LALA0_S01e17854g	similar to uniprot|P41834 Saccharomyces cerevisiae YOR075W UFE1 t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER
LALA0_S01e17876g	some similarities with uniprot|Q08491 Saccharomyces cerevisiae YOR076C (ohnolog of YKR084C) SKI7 Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype
LALA0_S01e17898g	similar to uniprot|C5DJP5 Lachancea thermotolerans KLTH0F18084g hypothetical protein
LALA0_S01e17920g	similar to uniprot|P22354 Saccharomyces cerevisiae YKR085C MRPL20 Mitochondrial ribosomal protein of the large subunit
LALA0_S01e17942g	similar to uniprot|P15938 Saccharomyces cerevisiae YKR086W PRP16 DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step
LALA0_S01e17964g	similar to uniprot|P36163 Saccharomyces cerevisiae YKR087C OMA1 Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
LALA0_S01e17986g	similar to uniprot|P40962 Saccharomyces cerevisiae YOR077W RTS2 Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
LALA0_S01e18008g	similar to uniprot|P36164 Saccharomyces cerevisiae YKR088C TVP38 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S01e18030g	weakly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
LALA0_S01e18052g	similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein
LALA0_S01e18074g	similar to uniprot|O00033 Saccharomyces cerevisiae YOR078W BUD21 Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
LALA0_S01e18096g	similar to uniprot|Q12067 Saccharomyces cerevisiae YOR079C ATX2 Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation
LALA0_S01e18118g	weakly similar to uniprot|Q7LGN4 Saccharomyces cerevisiae YOR080W DIA2 Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth
LALA0_S01e18140g	similar to uniprot|Q12043 Saccharomyces cerevisiae YOR081C (ohnolog of YKR089C) TGL5 Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate
LALA0_S01e18162g	similar to uniprot|P40016 Saccharomyces cerevisiae YER021W RPN3 Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
LALA0_S01e18184g	similar to uniprot|P32569 Saccharomyces cerevisiae YER022W SRB4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
LALA0_S01e18206g	similar to uniprot|P47155 Saccharomyces cerevisiae YJR118C ILM1 Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
LALA0_S01e18228g	highly similar to uniprot|P32263 Saccharomyces cerevisiae YER023W PRO3 Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
LALA0_S01e18250g	similar to uniprot|P47156 Saccharomyces cerevisiae YJR119C JHD2 JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
LALA0_S01e18272g	highly similar to uniprot|P00830 Saccharomyces cerevisiae YJR121W ATP2 Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
LALA0_S01e18294g	similar to uniprot|P47158 Saccharomyces cerevisiae YJR122W IBA57 Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system
LALA0_S01e18316g	highly similar to uniprot|P26783 Saccharomyces cerevisiae YJR123W RPS5 Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
LALA0_S01e18338g	weakly similar to uniprot|P40017 Saccharomyces cerevisiae YER024W YAT2 Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
LALA0_S01e18360g	similar to uniprot|P47159 Saccharomyces cerevisiae YJR124C Putative protein of unknown function; expression induced under calcium shortage
LALA0_S01e18382g	similar to uniprot|P08638 Saccharomyces cerevisiae YLR451W LEU3 Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis
LALA0_S01e18404g	highly similar to uniprot|P32481 Saccharomyces cerevisiae YER025W GCD11 Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
LALA0_S01e18426g	similar to uniprot|P11972 Saccharomyces cerevisiae YLR452C SST2 GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
LALA0_S01e18448g	similar to uniprot|P23293 Saccharomyces cerevisiae YPR161C SGV1 Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins
LALA0_S01e18470g	similar to uniprot|Q06208 Saccharomyces cerevisiae YLR453C (ohnolog of YPR162C) RIF2 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
LALA0_S01e18558g	highly similar to uniprot|P10963 Saccharomyces cerevisiae YKR097W PCK1 Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
LALA0_S01e18580g	similar to uniprot|P40454 Saccharomyces cerevisiae YIL153W RRD1 Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex
LALA0_S01e18602g	similar to uniprot|P32351 Saccharomyces cerevisiae YIL154C IMP2' Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
LALA0_S01e18624g	similar to uniprot|P32191 Saccharomyces cerevisiae YIL155C GUT2 Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
LALA0_S01e18646g	similar to uniprot|P40453 Saccharomyces cerevisiae YIL156W (ohnolog of YKR098C) UBP7 Ubiquitin-specificprotease that cleaves ubiquitin-protein fusions
LALA0_S01e18668g	weakly similar to uniprot|P22035 Saccharomyces cerevisiae YKR099W BAS1 Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
LALA0_S01e18690g	highly similar to uniprot|Q2V2P4 Saccharomyces cerevisiae YIL156W-B Putative protein of unknown function, originally identified based on homology to Ashbya gossypii and other related yeasts
LALA0_S01e18712g	similar to uniprot|P40452 Saccharomyces cerevisiae YIL157C COA1 Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly
LALA0_S01e18734g	similar to uniprot|P40451 Saccharomyces cerevisiae YIL158W (ohnolog of YKR100C) AIM20 Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S01e18756g	similar to uniprot|P40450 Saccharomyces cerevisiae YIL159W BNR1 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
LALA0_S01e18778g	similar to uniprot|P53630 Saccharomyces cerevisiae YNR057C BIO4 Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
LALA0_S01e18800g	similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
LALA0_S01e18822g	weakly similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
LALA0_S01e18844g	weakly similar to uniprot|P40449 Saccharomyces cerevisiae YIL161W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
LALA0_S01e18866g	similar to uniprot|P27796 Saccharomyces cerevisiae YIL160C POT1 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
LALA0_S01e18888g	similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin
LALA0_S01e18910g	weakly similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
LALA0_S01e18932g	similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
LALA0_S01e18954g	similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny
LALA0_S01e18976g	similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W YCT1 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
LALA0_S01e18998g	similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
LALA0_S01e19020g	highly similar to uniprot|C5DC69 Lachancea thermotolerans KLTH0B00462g flavin-containing monooxygenase
LALA0_S01e19042g	weakly similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
LALA0_S01e19064g	weakly similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
LALA0_S01e19086g	similar to uniprot|Q6CEC0 Yarrowia lipolytica YALI0B16852g hypothetical protein
LALA0_S01e19108g	weakly similar to uniprot|Q05016 Saccharomyces cerevisiae YMR226C NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
LALA0_S01e19130g	weakly similar to Lachancea thermotolerans KLTH0E03080g hypothetical protein
LALA0_S01e19152g	highly similar to uniprot|P0CD99 Saccharomyces cerevisiae YDL247W MPH2 Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication
LALA0_S01e19174g	highly similar to uniprot|P38158 Saccharomyces cerevisiae YBR299W MAL32 Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
LALA0_S01e19196g	some similarities with uniprot|Q12127 Saccharomyces cerevisiae YLR110C (ohnolog of YDR133C) CCW12 Cell wall mannoprotein with a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip
LALA0_S01e19218g	weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
LALA0_S01e19240g	similar to uniprot|P36060 Saccharomyces cerevisiae YKL150W MCR1 Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
LALA0_S01e19284g	similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
LALA0_S01e19306g	weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C (ohnolog of YER057C) MMF1 Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
LALA0_S01e19328g	weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
LALA0_S01e19350g	weakly similar to uniprot|Q12139 Saccharomyces cerevisiae YPR022C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
LALA0_S01e19372g	similar to uniprot|P53095 Saccharomyces cerevisiae YGL196W DSD1 D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate
LALA0_S01e19394g	highly similar to Lachancea thermotolerans KLTH0F03982g hypothetical protein
LALA0_S01e19416g	some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W FLO5 Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
LALA0_S02e00100g	highly similar to uniprot|P36533 Saccharomyces cerevisiae YML009C MRPL39 Mitochondrial ribosomal protein of the large subunit
LALA0_S02e00122g	similar to uniprot|P27692 Saccharomyces cerevisiae YML010W SPT5 Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing; forms a complex with Spt4p; contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p
LALA0_S02e00144g	similar to uniprot|Q04231 Saccharomyces cerevisiae YML011C RAD33 Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
LALA0_S02e00166g	highly similar to uniprot|P54837 Saccharomyces cerevisiae YML012W ERV25 Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
LALA0_S02e00188g	similar to uniprot|P32898 Saccharomyces cerevisiae YDR430C CYM1 Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology
LALA0_S02e00210g	similar to uniprot|Q01560 Saccharomyces cerevisiae YDR432W NPL3 RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
LALA0_S02e00232g	similar to uniprot|Q04228 Saccharomyces cerevisiae YML013W UBX2 Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain
LALA0_S02e00254g	similar to uniprot|P49957 Saccharomyces cerevisiae YML014W TRM9 tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocin
LALA0_S02e00276g	similar to uniprot|Q04080 Saccharomyces cerevisiae YDR434W GPI17 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog
LALA0_S02e00298g	similar to uniprot|Q04226 Saccharomyces cerevisiae YML015C TAF11 TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
LALA0_S02e00320g	similar to uniprot|Q04081 Saccharomyces cerevisiae YDR435C PPM1 Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
LALA0_S02e00342g	similar to uniprot|Q04370 Saccharomyces cerevisiae YMR026C PEX12 C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
LALA0_S02e00364g	weakly similar to uniprot|Q04368 Saccharomyces cerevisiae YMR025W CSI1 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
LALA0_S02e00386g	similar to uniprot|P36516 Saccharomyces cerevisiae YMR024W MRPL3 Mitochondrial ribosomal protein of the large subunit
LALA0_S02e00408g	weakly similar to uniprot|C5DGR7 Lachancea thermotolerans KLTH0D07524g hypothetical protein
LALA0_S02e00430g	similar to uniprot|P32559 Saccharomyces cerevisiae YMR023C MSS1 Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3
LALA0_S02e00452g	similar to uniprot|P35727 Saccharomyces cerevisiae YKL061W BLI1 Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
LALA0_S02e00474g	similar to uniprot|P36090 Saccharomyces cerevisiae YKL047W Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S02e00496g	similar to uniprot|P36091 Saccharomyces cerevisiae YKL046C DCW1 Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
LALA0_S02e00518g	highly similar to uniprot|Q02159 Saccharomyces cerevisiae YMR022W UBC7 Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
LALA0_S02e00540g	similar to uniprot|P35192 Saccharomyces cerevisiae YMR021C MAC1 Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
LALA0_S02e00562g	similar to uniprot|P50264 Saccharomyces cerevisiae YMR020W FMS1 Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
LALA0_S02e00584g	similar to uniprot|P20457 Saccharomyces cerevisiae YKL045W PRI2 Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
LALA0_S02e00606g	some similarities with uniprot|P50104 Saccharomyces cerevisiae YMR019W STB4 Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters
LALA0_S02e00628g	weakly similar to uniprot|P53438 Saccharomyces cerevisiae YMR016C (ohnolog of YKL043W) SOK2 Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
LALA0_S02e00650g	weakly similar to uniprot|P36094 Saccharomyces cerevisiae YKL042W SPC42 Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
LALA0_S02e00672g	highly similar to uniprot|P54781 Saccharomyces cerevisiae YMR015C ERG5 C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
LALA0_S02e00694g	similar to uniprot|Q04347 Saccharomyces cerevisiae YMR014W BUD22 Protein required for 18S rRNA maturation and small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern
LALA0_S02e00716g	similar to uniprot|P20048 Saccharomyces cerevisiae YMR013C SEC59 Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
LALA0_S02e00738g	similar to uniprot|Q03690 Saccharomyces cerevisiae YMR012W CLU1 eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
LALA0_S02e00782g	highly similar to uniprot|P36095 Saccharomyces cerevisiae YKL041W VPS24 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
LALA0_S02e00804g	weakly similar to uniprot|P21957 Saccharomyces cerevisiae YHL020C OPI1 Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
LALA0_S02e00826g	similar to uniprot|C5DGR1 Lachancea thermotolerans KLTH0D07392g hypothetical protein
LALA0_S02e00848g	similar to uniprot|P38700 Saccharomyces cerevisiae YHL019C APM2 Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
LALA0_S02e00870g	similar to uniprot|P38744 Saccharomyces cerevisiae YHL018W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
LALA0_S02e00892g	similar to uniprot|P32860 Saccharomyces cerevisiae YKL040C NFU1 Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
LALA0_S02e00914g	similar to uniprot|P38745 Saccharomyces cerevisiae YHL017W (ohnolog of YKL039W) Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles
LALA0_S02e00936g	similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
LALA0_S02e00958g	similar to uniprot|C5DGP5 Lachancea thermotolerans KLTH0D06996g hypothetical protein
LALA0_S02e00980g	highly similar to uniprot|P38701 Saccharomyces cerevisiae YHL015W RPS20 Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
LALA0_S02e01002g	similar to uniprot|P38746 Saccharomyces cerevisiae YHL014C YLF2 Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S02e01024g	similar to uniprot|P38747 Saccharomyces cerevisiae YHL013C OTU2 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization
LALA0_S02e01068g	weakly similar to uniprot|P32862 Saccharomyces cerevisiae YKL038W (ohnolog of YBR033W EDS1) RGT1 Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
LALA0_S02e01090g	highly similar to uniprot|P38709 Saccharomyces cerevisiae YHL012W (ohnolog of YKL035W) Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase
LALA0_S02e01112g	similar to uniprot|P36096 Saccharomyces cerevisiae YKL034W TUL1 Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes
LALA0_S02e01134g	similar to uniprot|Q86ZR7 Saccharomyces cerevisiae YKL033W-A Putative protein of unknown function; similar to uncharacterized proteins from other fungi
LALA0_S02e01156g	highly similar to uniprot|P38689 Saccharomyces cerevisiae YHL011C PRS3 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
LALA0_S02e01178g	similar to uniprot|P38748 Saccharomyces cerevisiae YHL010C ETP1 Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
LALA0_S02e01200g	weakly similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W LYP1 Lysine permease; one of threeamino acid permeases (Alp1p, Can1p, Lyp1p) responsible foruptake of cationic amino acids
LALA0_S02e01222g	similar to uniprot|P36097 Saccharomyces cerevisiae YKL033W TTI1 Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies
LALA0_S02e01244g	similar to uniprot|P38750 Saccharomyces cerevisiae YHL008C Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
LALA0_S02e01266g	similar to uniprot|Q04264 Saccharomyces cerevisiae YMR076C PDS5 Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis
LALA0_S02e01288g	similar to uniprot|Q04779 Saccharomyces cerevisiae YMR075W RCO1 Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
LALA0_S02e01310g	similar to uniprot|Q04773 Saccharomyces cerevisiae YMR074C Protein with homology to human PDCD5, which is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene
LALA0_S02e01332g	highly similar to uniprot|C5DGP1 Lachancea thermotolerans KLTH0D06886g hypothetical protein
LALA0_S02e01354g	similar to uniprot|Q04772 Saccharomyces cerevisiae YMR073C IRC21 Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
LALA0_S02e01376g	weakly similar to uniprot|Q02486 Saccharomyces cerevisiae YMR072W (ohnolog of YKL032C) ABF2 Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
LALA0_S02e01398g	similar to uniprot|C5DGJ9 Lachancea thermotolerans KLTH0D05940g hypothetical protein
LALA0_S02e01420g	highly similar to uniprot|Q04767 Saccharomyces cerevisiae YMR071C TVP18 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
LALA0_S02e01442g	weakly similar to uniprot|P54785 Saccharomyces cerevisiae YMR070W MOT3 Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes; can form the [MOT3+] prion
LALA0_S02e01464g	weakly similar to uniprot|Q04751 Saccharomyces cerevisiae YMR069W NAT4 N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A
LALA0_S02e01486g	weakly similar to uniprot|Q12145 Saccharomyces cerevisiae YPR013C Putative zinc finger protein; YPR013C is not an essential gene
LALA0_S02e01508g	similar to uniprot|P38757 Saccharomyces cerevisiae YHR004C NEM1 Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
LALA0_S02e01530g	similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
LALA0_S02e01552g	highly similar to uniprot|P36013 Saccharomyces cerevisiae YKL029C MAE1 Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
LALA0_S02e01574g	similar to uniprot|P36100 Saccharomyces cerevisiae YKL028W TFA1 TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
LALA0_S02e01596g	similar to uniprot|P38756 Saccharomyces cerevisiae YHR003C (ohnolog of YKL027W) Protein of unknown function, localized to the mitochondrial outer membrane
LALA0_S02e01618g	similar to uniprot|P38702 Saccharomyces cerevisiae YHR002W LEU5 Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized
LALA0_S02e01640g	highly similar to uniprot|P38152 Saccharomyces cerevisiae YBR291C CTP1 Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
LALA0_S02e01662g	similar to uniprot|P38356 Saccharomyces cerevisiae YBR290W BSD2 Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
LALA0_S02e01684g	similar to uniprot|P18480 Saccharomyces cerevisiae YBR289W SNF5 Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p
LALA0_S02e01728g	similar to uniprot|P38153 Saccharomyces cerevisiae YBR288C APM3 Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
LALA0_S02e01750g	highly similar to uniprot|Q02207 Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
LALA0_S02e01772g	similar to uniprot|P37299 Saccharomyces cerevisiae YHR001W-A QCR10 Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain
LALA0_S02e01816g	similar to uniprot|Q02206 Saccharomyces cerevisiae YKR008W RSC4 Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p
LALA0_S02e01838g	similar to uniprot|Q02205 Saccharomyces cerevisiae YKR007W MEH1 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
LALA0_S02e01860g	similar to uniprot|Q02204 Saccharomyces cerevisiae YKR006C MRPL13 Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
LALA0_S02e01882g	weakly similar to uniprot|Q02202 Saccharomyces cerevisiae YKR004C ECM9 Non-essential protein of unknown function
LALA0_S02e01904g	highly similar to uniprot|P38755 Saccharomyces cerevisiae YHR001W (ohnolog of YKR003W) OSH7 Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
LALA0_S02e01926g	similar to uniprot|P29468 Saccharomyces cerevisiae YKR002W PAP1 Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
LALA0_S02e01948g	highly similar to uniprot|P21576 Saccharomyces cerevisiae YKR001C VPS1 Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis
LALA0_S02e01992g	highly similar to uniprot|Q02196 Saccharomyces cerevisiae YKL001C MET14 Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
LALA0_S02e02014g	highly similar to uniprot|P36108 Saccharomyces cerevisiae YKL002W DID4 Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
LALA0_S02e02036g	similar to uniprot|P28778 Saccharomyces cerevisiae YKL003C MRP17 Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator
LALA0_S02e02058g	similar to uniprot|P36107 Saccharomyces cerevisiae YKL004W AUR1 Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
LALA0_S02e02080g	weakly similar to uniprot|P36106 Saccharomyces cerevisiae YKL005C BYE1 Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
LALA0_S02e02102g	highly similar to uniprot|P38754 Saccharomyces cerevisiae YHL001W (ohnolog of YKL006W) RPL14B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein
LALA0_S02e02124g	highly similar to uniprot|P43682 Saccharomyces cerevisiae YKL006C-A SFT1 Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
LALA0_S02e02146g	similar to uniprot|P28495 Saccharomyces cerevisiae YKL007W CAP1 Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
LALA0_S02e02168g	similar to uniprot|P38753 Saccharomyces cerevisiae YHL002W HSE1 Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
LALA0_S02e02190g	similar to uniprot|P38703 Saccharomyces cerevisiae YHL003C (ohnolog of YKL008C) LAG1 Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
LALA0_S02e02212g	similar to uniprot|P32902 Saccharomyces cerevisiae YHL004W MRP4 Mitochondrial ribosomal protein of the small subunit
LALA0_S02e02234g	weakly similar to uniprot|P38751 Saccharomyces cerevisiae YHL006C SHU1 Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p
LALA0_S02e02256g	highly similar to uniprot|P33201 Saccharomyces cerevisiae YKL009W MRT4 Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
LALA0_S02e02278g	similar to uniprot|P33202 Saccharomyces cerevisiae YKL010C UFD4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins
LALA0_S02e02300g	some similarities with uniprot|Q12469 Saccharomyces cerevisiae YOL113W (ohnolog of YNL298W) SKM1 Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth
LALA0_S02e02322g	similar to uniprot|P35201 Saccharomyces cerevisiae YKL089W MIF2 Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p
LALA0_S02e02344g	weakly similar to uniprot|P36075 Saccharomyces cerevisiae YKL090W CUE2 Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
LALA0_S02e02366g	similar to uniprot|C5DGG9 Lachancea thermotolerans KLTH0D05236g hypothetical protein
LALA0_S02e02388g	weakly similar to uniprot|P38749 Saccharomyces cerevisiae YHL009C YAP3 Basic leucine zipper (bZIP) transcription factor
LALA0_S02e02432g	similar to uniprot|P49956 Saccharomyces cerevisiae YMR078C CTF18 Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint
LALA0_S02e02454g	highly similar to uniprot|P24280 Saccharomyces cerevisiae YMR079W (ohnolog of YKL091C) SEC14 Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPs
LALA0_S02e02476g	similar to uniprot|P33314 Saccharomyces cerevisiae YKL092C BUD2 GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types
LALA0_S02e02498g	highly similar to uniprot|P30771 Saccharomyces cerevisiae YMR080C NAM7 ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance
LALA0_S02e02520g	weakly similar to uniprot|P32488 Saccharomyces cerevisiae YMR081C (ohnolog of YKL093W) ISF1 Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
LALA0_S02e02542g	similar to uniprot|P28321 Saccharomyces cerevisiae YKL094W YJU3 Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
LALA0_S02e02564g	similar to uniprot|P28320 Saccharomyces cerevisiae YKL095W YJU2 Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing
LALA0_S02e02586g	some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance
LALA0_S02e02608g	some similarities with uniprot|P28319 Saccharomyces cerevisiae YKL096W CWP1 Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance
LALA0_S02e02630g	weakly similar to uniprot|P34246 Saccharomyces cerevisiae YKL098W MTC2 Protein of unknown function; mtc2 is synthetically sick with cdc13-1
LALA0_S02e02652g	similar to uniprot|P34247 Saccharomyces cerevisiae YKL099C UTP11 Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
LALA0_S02e02674g	highly similar to uniprot|P07246 Saccharomyces cerevisiae YMR083W ADH3 Mitochondrial alcoholdehydrogenase isozyme III; involved in the shuttling ofmitochondrial NADH to the cytosol under anaerobicconditions and ethanol production
LALA0_S02e02696g	similar to uniprot|P34244 Saccharomyces cerevisiae YKL101W HSL1 Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
LALA0_S02e02718g	similar to uniprot|P14904 Saccharomyces cerevisiae YKL103C LAP4 Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
LALA0_S02e02740g	highly similar to uniprot|A2P2R3 Saccharomyces cerevisiae YMR084W (ohnolog of YKL104C) Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains
LALA0_S02e02762g	weakly similar to uniprot|Q04279 Saccharomyces cerevisiae YMR086W (ohnolog of YKL105C) Component of the eisosome with unknown function; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cell periphery; expression is repressed by cAMP; similar to A. gossypii SEG gene which is important for stabilizing eisosomes
LALA0_S02e02784g	similar to uniprot|Q01802 Saccharomyces cerevisiae YKL106W AAT1 Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
LALA0_S02e02806g	similar to uniprot|Q04299 Saccharomyces cerevisiae YMR087W Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain
LALA0_S02e02828g	similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane
LALA0_S02e02850g	highly similar to uniprot|P40341 Saccharomyces cerevisiae YMR089C YTA12 Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
LALA0_S02e02872g	similar to uniprot|P32832 Saccharomyces cerevisiae YMR091C NPL6 Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length
LALA0_S02e02894g	similar to uniprot|P46680 Saccharomyces cerevisiae YMR092C AIP1 Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats
LALA0_S02e02916g	highly similar to uniprot|Q04305 Saccharomyces cerevisiae YMR093W UTP15 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
LALA0_S02e02938g	weakly similar to uniprot|P34252 Saccharomyces cerevisiae YKL108W SLD2 Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; required for the S phase checkpoint
LALA0_S02e02960g	weakly similar to uniprot|P35203 Saccharomyces cerevisiae YMR094W CTF13 Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
LALA0_S02e02982g	similar to uniprot|P43544 Saccharomyces cerevisiae YFL060C SNO3 Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin
LALA0_S02e03004g	highly similar to uniprot|P53824 Saccharomyces cerevisiae YNL333W Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p
LALA0_S02e03026g	similar to uniprot|C5DFT5 Lachancea thermotolerans KLTH0D17776g hypothetical protein
LALA0_S02e03048g	similar to uniprot|Q03151 Saccharomyces cerevisiae YMR097C MTG1 Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
LALA0_S02e03070g	similar to uniprot|P34253 Saccharomyces cerevisiae YKL110C KTI12 Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
LALA0_S02e03092g	weakly similar to uniprot|Q03153 Saccharomyces cerevisiae YMR098C ATP25 Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
LALA0_S02e03114g	some similarities with uniprot|P14164 Saccharomyces cerevisiae YKL112W ABF1 DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
LALA0_S02e03136g	highly similar to uniprot|P26793 Saccharomyces cerevisiae YKL113C RAD27 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
LALA0_S02e03158g	similar to uniprot|P22936 Saccharomyces cerevisiae YKL114C APN1 Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
LALA0_S02e03180g	similar to uniprot|P28708 Saccharomyces cerevisiae YKL116C PRR1 Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
LALA0_S02e03202g	highly similar to uniprot|Q03161 Saccharomyces cerevisiae YMR099C Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
LALA0_S02e03224g	similar to uniprot|P28707 Saccharomyces cerevisiae YKL117W SBA1 Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
LALA0_S02e03246g	similar to uniprot|P32343 Saccharomyces cerevisiae YKL124W SSH4 Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
LALA0_S02e03268g	similar to uniprot|P32342 Saccharomyces cerevisiae YKL122C SRP21 Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
LALA0_S02e03290g	similar to uniprot|Q03177 Saccharomyces cerevisiae YMR102C (ohnolog of YKL121W) Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
LALA0_S02e03312g	highly similar to uniprot|P32332 Saccharomyces cerevisiae YKL120W OAC1 Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family
LALA0_S02e03334g	similar to uniprot|Q03175 Saccharomyces cerevisiae YMR101C SRT1 Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
LALA0_S02e03356g	similar to uniprot|P32341 Saccharomyces cerevisiae YKL119C VPH2 Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
LALA0_S02e03378g	similar to uniprot|Q03162 Saccharomyces cerevisiae YMR100W MUB1 MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene
LALA0_S02e03400g	similar to uniprot|P36070 Saccharomyces cerevisiae YKL125W RRN3 Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA
LALA0_S02e03422g	similar to uniprot|P18961 Saccharomyces cerevisiae YMR104C (ohnolog of YKL126W) YPK2 Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
LALA0_S02e03444g	highly similar to uniprot|P37012 Saccharomyces cerevisiae YMR105C (ohnolog of YKL127W) PGM2 Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
LALA0_S02e03466g	similar to uniprot|Q04437 Saccharomyces cerevisiae YMR106C YKU80 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
LALA0_S02e03510g	similar to uniprot|P35999 Saccharomyces cerevisiae YKL134C 37165 Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis
LALA0_S02e03532g	similar to uniprot|Q04472 Saccharomyces cerevisiae YMR115W (ohnolog of YKL133C) MGR3 Subunit of themitochondrial (mt) i-AAA protease supercomplex, whichdegrades misfolded mitochondrial proteins; forms asubcomplex with Mgr1p that binds to substrates tofacilitate proteolysis; required for growth of cellslacking mtDNA
LALA0_S02e03554g	similar to uniprot|Q04471 Saccharomyces cerevisiae YMR114C Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene
LALA0_S02e03576g	similar to uniprot|Q12676 Saccharomyces cerevisiae YMR113W (ohnolog of YKL132C) FOL3 Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
LALA0_S02e03598g	similar to uniprot|Q99278 Saccharomyces cerevisiae YMR112C MED11 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
LALA0_S02e03620g	similar to uniprot|P40087 Saccharomyces cerevisiae YER143W DDI1 DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains
LALA0_S02e03642g	weakly similar to uniprot|Q04461 Saccharomyces cerevisiae YMR111C Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene
LALA0_S02e03664g	similar to uniprot|P36068 Saccharomyces cerevisiae YKL130C SHE2 RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
LALA0_S02e03686g	similar to uniprot|P81450 Saccharomyces cerevisiae YML081C-A ATP18 Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
LALA0_S02e03708g	similar to uniprot|Q04533 Saccharomyces cerevisiae YML082W (ohnolog of YJR130C) Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene
LALA0_S02e03730g	weakly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
LALA0_S02e03752g	similar to uniprot|P32906 Saccharomyces cerevisiae YJR131W MNS1 Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane
LALA0_S02e03774g	similar to uniprot|P38877 Saccharomyces cerevisiae YHR191C CTF8 Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion
LALA0_S02e03796g	similar to uniprot|P38878 Saccharomyces cerevisiae YHR192W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS
LALA0_S02e03818g	similar to uniprot|P38879 Saccharomyces cerevisiae YHR193C EGD2 Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
LALA0_S02e03862g	similar to uniprot|P38880 Saccharomyces cerevisiae YHR194W MDM31 Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
LALA0_S02e03884g	weakly similar to uniprot|C5DFS6 Lachancea thermotolerans KLTH0D17556g hypothetical protein
LALA0_S02e03906g	similar to uniprot|P46970 Saccharomyces cerevisiae YJR132W NMD5 Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog
LALA0_S02e03928g	similar to uniprot|P38882 Saccharomyces cerevisiae YHR196W UTP9 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
LALA0_S02e03950g	highly similar to uniprot|P47165 Saccharomyces cerevisiae YJR133W XPT1 Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
LALA0_S02e03972g	weakly similar to uniprot|P47166 Saccharomyces cerevisiae YJR134C SGM1 Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus
LALA0_S02e03994g	similar to uniprot|P38883 Saccharomyces cerevisiae YHR197W RIX1 Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
LALA0_S02e04016g	similar to uniprot|P47167 Saccharomyces cerevisiae YJR135C MCM22 Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner
LALA0_S02e04038g	highly similar to uniprot|P57744 Saccharomyces cerevisiae YJR135W-A TIM8 Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome
LALA0_S02e04060g	similar to uniprot|P47168 Saccharomyces cerevisiae YJR136C TTI2 Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm
LALA0_S02e04082g	similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein
LALA0_S02e04104g	similar to uniprot|P38884 Saccharomyces cerevisiae YHR198C AIM18 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S02e04126g	similar to uniprot|P47169 Saccharomyces cerevisiae YJR137C MET5 Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
LALA0_S02e04170g	highly similar to uniprot|P40422 Saccharomyces cerevisiae YHR143W-A RPC10 RNA polymerase subunit ABC10-alpha, found in RNA polymerase complexes I, II, and III
LALA0_S02e04192g	weakly similar to uniprot|P53890 Saccharomyces cerevisiae YNL166C BNI5 Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
LALA0_S02e04214g	weakly similar to uniprot|P53891 Saccharomyces cerevisiae YNL165W Putative protein of unknown function; YNL165W is not an essential gene
LALA0_S02e04236g	similar to uniprot|P38844 Saccharomyces cerevisiae YHR143W DSE2 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
LALA0_S02e04258g	weakly similar to uniprot|P53892 Saccharomyces cerevisiae YNL164C IBD2 Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p
LALA0_S02e04280g	similar to uniprot|P53893 Saccharomyces cerevisiae YNL163C RIA1 Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p)
LALA0_S02e04302g	similar to uniprot|Q3E7A8 Saccharomyces cerevisiae YNL162W-A Putative protein of unknown function; identified by homology
LALA0_S02e04324g	similar to uniprot|P38843 Saccharomyces cerevisiae YHR142W CHS7 Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
LALA0_S02e04346g	highly similar to uniprot|P02405 Saccharomyces cerevisiae YHR141C (ohnolog of YNL162W) RPL42B Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
LALA0_S02e04368g	similar to uniprot|P53894 Saccharomyces cerevisiae YNL161W CBK1 Serine/threonine protein kinase that regulates cell morphogenesis pathways, including cell wall biosynthesis, mating projection morphology, bipolar bud site selection; regulates SRL1 mRNA localization via phosphorylation of substrate Ssd1p
LALA0_S02e04390g	similar to uniprot|P38842 Saccharomyces cerevisiae YHR140W Putative integral membrane protein of unknown function
LALA0_S02e04412g	similar to uniprot|P13130 Saccharomyces cerevisiae YHR139C (ohnolog of YNL160W) SPS100 Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin
LALA0_S02e04434g	similar to uniprot|Q03049 Saccharomyces cerevisiae YDR541C Putative dihydrokaempferol 4-reductase
LALA0_S02e04456g	highly similar to uniprot|P41948 Saccharomyces cerevisiae YNL142W MEP2 Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
LALA0_S02e04478g	similar to uniprot|P38841 Saccharomyces cerevisiae YHR138C Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
LALA0_S02e04500g	highly similar to uniprot|P53900 Saccharomyces cerevisiae YNL153C GIM3 Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
LALA0_S02e04522g	similar to uniprot|P38840 Saccharomyces cerevisiae YHR137W ARO9 Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
LALA0_S02e04544g	hypothetical protein
LALA0_S02e04566g	similar to uniprot|P32419 Saccharomyces cerevisiae YDL078C MDH3 Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
LALA0_S02e04588g	similar to uniprot|P39110 Saccharomyces cerevisiae YMR138W CIN4 GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
LALA0_S02e04610g	weakly similar to uniprot|P30620 Saccharomyces cerevisiae YMR137C PSO2 Nuclease required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation
LALA0_S02e04632g	weakly similar to uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
LALA0_S02e04654g	similar to uniprot|P40208 Saccharomyces cerevisiae YMR135C GID8 Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
LALA0_S02e04676g	similar to uniprot|P40207 Saccharomyces cerevisiae YMR134W Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
LALA0_S02e04698g	hypothetical protein
LALA0_S02e04720g	hypothetical protein
LALA0_S02e04742g	weakly similar to Lachancea thermotolerans KLTH0E09042g hypothetical protein
LALA0_S02e04764g	similar to uniprot|P40206 Saccharomyces cerevisiae YMR132C JLP2 Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
LALA0_S02e04786g	highly similar to uniprot|Q04225 Saccharomyces cerevisiae YMR131C RRB1 Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
LALA0_S02e04808g	similar to uniprot|P40395 Saccharomyces cerevisiae YLR039C RIC1 Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
LALA0_S02e04830g	highly similar to uniprot|Q01519 Saccharomyces cerevisiae YLR038C COX12 Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated
LALA0_S02e04852g	similar to uniprot|Q04223 Saccharomyces cerevisiae YMR130W Putative protein of unknown function; YMR130W is not an essential gene
LALA0_S02e04874g	similar to uniprot|P39685 Saccharomyces cerevisiae YMR129W POM152 Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase
LALA0_S02e04896g	highly similar to uniprot|Q12078 Saccharomyces cerevisiae YLR034C SMF3 Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins
LALA0_S02e04918g	similar to uniprot|Q07979 Saccharomyces cerevisiae YLR033W RSC58 Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
LALA0_S02e04940g	similar to uniprot|Q04217 Saccharomyces cerevisiae YMR128W ECM16 Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
LALA0_S02e04962g	similar to uniprot|P40963 Saccharomyces cerevisiae YMR127C SAS2 Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
LALA0_S02e04984g	similar to uniprot|P32849 Saccharomyces cerevisiae YLR032W RAD5 DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p
LALA0_S02e05006g	similar to uniprot|Q04216 Saccharomyces cerevisiae YMR126C DLT1 Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
LALA0_S02e05028g	similar to uniprot|P34160 Saccharomyces cerevisiae YMR125W STO1 Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
LALA0_S02e05050g	weakly similar to uniprot|P39523 Saccharomyces cerevisiae YMR124W (ohnolog of YLR031W) Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
LALA0_S02e05072g	similar to uniprot|Q03880 Saccharomyces cerevisiae YMR123W PKR1 V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0)
LALA0_S02e05094g	similar to uniprot|Q3E842 Saccharomyces cerevisiae YMR122W-A Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
LALA0_S02e05116g	similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein
LALA0_S02e05138g	highly similar to uniprot|P54780 Saccharomyces cerevisiae YMR121C (ohnolog of YLR029C) RPL15B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
LALA0_S02e05160g	highly similar to uniprot|P38009 Saccharomyces cerevisiae YMR120C (ohnolog of YLR028C) ADE17 Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine
LALA0_S02e05182g	similar to uniprot|P53983 Saccharomyces cerevisiae YNL008C (ohnolog of YMR119W) ASI3 Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
LALA0_S02e05226g	similar to uniprot|Q02721 Saccharomyces cerevisiae YLR329W REC102 Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
LALA0_S02e05248g	similar to uniprot|P53209 Saccharomyces cerevisiae YGR016W Putative protein of unknown function
LALA0_S02e05270g	similar to uniprot|P53208 Saccharomyces cerevisiae YGR015C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
LALA0_S02e05292g	weakly similar to uniprot|P41809 Saccharomyces cerevisiae YDR420W HKR1 Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
LALA0_S02e05314g	similar to uniprot|P53207 Saccharomyces cerevisiae YGR013W SNU71 Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
LALA0_S02e05336g	similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Putative cysteine synthase, localized to the mitochondrial outer membrane
LALA0_S02e05380g	hypothetical protein
LALA0_S02e05402g	similar to uniprot|C5DGC0 Lachancea thermotolerans KLTH0D04070g hypothetical protein
LALA0_S02e05424g	similar to uniprot|P53204 Saccharomyces cerevisiae YGR010W (ohnolog of YLR328W) NMA2 Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+)
LALA0_S02e05446g	weakly similar to uniprot|P47043 Saccharomyces cerevisiae YJL056C ZAP1 Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains
LALA0_S02e05468g	similar to uniprot|P38347 Saccharomyces cerevisiae YBR271W Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis
LALA0_S02e05490g	similar to uniprot|P47042 Saccharomyces cerevisiae YJL057C IKS1 Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
LALA0_S02e05512g	similar to uniprot|P47041 Saccharomyces cerevisiae YJL058C (ohnolog of YBR270C) BIT61 Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity
LALA0_S02e05534g	similar to uniprot|P47040 Saccharomyces cerevisiae YJL059W YHC3 Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)
LALA0_S02e05556g	highly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
LALA0_S02e05578g	similar to uniprot|P89105 Saccharomyces cerevisiae YOL145C CTR9 Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; contains TPR repeats; possibly involved in transcription elongation as a component of the PAF complex
LALA0_S02e05600g	similar to uniprot|Q12146 Saccharomyces cerevisiae YOL146W PSF3 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
LALA0_S02e05622g	similar to uniprot|Q12462 Saccharomyces cerevisiae YOL147C PEX11 Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
LALA0_S02e05644g	similar to uniprot|P50875 Saccharomyces cerevisiae YOL148C SPT20 Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
LALA0_S02e05666g	similar to uniprot|Q12517 Saccharomyces cerevisiae YOL149W DCP1 Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p
LALA0_S02e05688g	similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
LALA0_S02e05710g	weakly similar to uniprot|P53857 Saccharomyces cerevisiae YNL234W Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1
LALA0_S02e05732g	similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin
LALA0_S02e05754g	similar to uniprot|P40309 Saccharomyces cerevisiae YJL094C KHA1 Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
LALA0_S02e05776g	similar to uniprot|P43623 Saccharomyces cerevisiae YFR055W IRC7 Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner
LALA0_S02e05798g	highly similar to uniprot|G8ZP09 Torulaspora delbrueckii TDEL_0B02240 hypothetical protein
LALA0_S02e05820g	some similarities with uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
LALA0_S02e05842g	weakly similar to uniprot|P43634 Saccharomyces cerevisiae YLR098C CHA4 DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
LALA0_S02e05864g	some similarities with uniprot|P28273 Saccharomyces cerevisiae YKL215C OXP1 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S02e05886g	weakly similar to uniprot|P47039 Saccharomyces cerevisiae YJL060W BNA3 Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
LALA0_S02e05908g	highly similar to uniprot|C5DC09 Lachancea thermotolerans KLTH0A06908g hypothetical protein
LALA0_S02e05930g	similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
LALA0_S02e05952g	some similarities with uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
LALA0_S02e05974g	similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
LALA0_S02e05996g	similar to uniprot|P39721 Saccharomyces cerevisiae YAL049C AIM2 Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor
LALA0_S02e06018g	weakly similar to uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
LALA0_S02e06040g	similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W (ohnolog of YPR058W) YMC2 Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
LALA0_S02e06062g	similar to uniprot|P43549 Saccharomyces cerevisiae YFL054C Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
LALA0_S02e06084g	similar to uniprot|P53743 Saccharomyces cerevisiae YNR054C ESF2 Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
LALA0_S02e06106g	highly similar to uniprot|P53742 Saccharomyces cerevisiae YNR053C NOG2 Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
LALA0_S02e06128g	similar to uniprot|P39008 Saccharomyces cerevisiae YNR052C POP2 RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
LALA0_S02e06150g	similar to uniprot|P53741 Saccharomyces cerevisiae YNR051C BRE5 Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
LALA0_S02e06172g	similar to uniprot|P25366 Saccharomyces cerevisiae YCR095C OCA4 Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
LALA0_S02e06194g	highly similar to uniprot|P38999 Saccharomyces cerevisiae YNR050C LYS9 Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112
LALA0_S02e06216g	weakly similar to uniprot|P53604 Saccharomyces cerevisiae YNR049C MSO1 Probable component of thesecretory vesicle docking complex, acts at a late step insecretion; shows genetic and physical interactions withSec1p; required for prospore membrane formation duringsporulation
LALA0_S02e06238g	highly similar to uniprot|P21734 Saccharomyces cerevisiae YDR177W UBC1 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response
LALA0_S02e06260g	similar to uniprot|P25656 Saccharomyces cerevisiae YCR094W (ohnolog of YNR048W) CDC50 Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Ynr048wp and Lem3p
LALA0_S02e06282g	similar to uniprot|P25655 Saccharomyces cerevisiae YCR093W CDC39 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
LALA0_S02e06304g	similar to uniprot|P25336 Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability
LALA0_S02e06326g	similar to uniprot|P25341 Saccharomyces cerevisiae YCR091W (ohnolog of YNR047W) KIN82 Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p
LALA0_S02e06348g	highly similar to uniprot|P53738 Saccharomyces cerevisiae YNR046W TRM112 Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin
LALA0_S02e06370g	weakly similar to uniprot|P07390 Saccharomyces cerevisiae YNR045W PET494 Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
LALA0_S02e06392g	similar to uniprot|P25654 Saccharomyces cerevisiae YCR090C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
LALA0_S02e06414g	weakly similar to uniprot|P25653 Saccharomyces cerevisiae YCR089W (ohnolog of YNR044W) FIG2 Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating
LALA0_S02e06436g	similar to uniprot|P15891 Saccharomyces cerevisiae YCR088W ABP1 Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization
LALA0_S02e06458g	similar to uniprot|P37263 Saccharomyces cerevisiae YCR087C-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
LALA0_S02e06480g	similar to uniprot|P25651 Saccharomyces cerevisiae YCR086W CSM1 Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
LALA0_S02e06502g	similar to uniprot|P18323 Saccharomyces cerevisiae YCR084C TUP1 General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
LALA0_S02e06524g	weakly similar to uniprot|P35995 Saccharomyces cerevisiae YKL222C Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
LALA0_S02e06546g	highly similar to uniprot|P32377 Saccharomyces cerevisiae YNR043W MVD1 Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
LALA0_S02e06568g	similar to uniprot|P25649 Saccharomyces cerevisiae YCR082W AHC2 Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex
LALA0_S02e06590g	similar to uniprot|P25372 Saccharomyces cerevisiae YCR083W TRX3 Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p
LALA0_S02e06612g	weakly similar to uniprot|P53736 Saccharomyces cerevisiae YNR040W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S02e06634g	similar to uniprot|P32378 Saccharomyces cerevisiae YNR041C COQ2 Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
LALA0_S02e06656g	similar to uniprot|P53735 Saccharomyces cerevisiae YNR039C ZRG17 Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc
LALA0_S02e06678g	similar to uniprot|P25648 Saccharomyces cerevisiae YCR081W SRB8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
LALA0_S02e06700g	similar to uniprot|P53734 Saccharomyces cerevisiae YNR038W DBP6 Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
LALA0_S02e06722g	highly similar to uniprot|P53733 Saccharomyces cerevisiae YNR037C RSM19 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
LALA0_S02e06744g	similar to uniprot|P25646 Saccharomyces cerevisiae YCR079W PTC6 Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
LALA0_S02e06766g	similar to uniprot|P53732 Saccharomyces cerevisiae YNR036C MRPS12 Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins
LALA0_S02e06788g	similar to uniprot|P53731 Saccharomyces cerevisiae YNR035C ARC35 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
LALA0_S02e06810g	similar to uniprot|P25644 Saccharomyces cerevisiae YCR077C PAT1 Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p
LALA0_S02e06832g	weakly similar to uniprot|P25659 Saccharomyces cerevisiae YCR076C Putative protein of unknown function; YCR076C is not an essential gene
LALA0_S02e06854g	similar to uniprot|Q3E830 Saccharomyces cerevisiae YCR075W-A (ohnolog of YNR034W-A) Putative protein of unknown function; identified by homology to Ashbya gossypii
LALA0_S02e06876g	similar to uniprot|C5DBY7 Lachancea thermotolerans KLTH0A06402g hypothetical protein
LALA0_S02e06898g	similar to uniprot|P17261 Saccharomyces cerevisiae YCR075C ERS1 Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
LALA0_S02e06920g	similar to uniprot|P37262 Saccharomyces cerevisiae YCR073W-A (ohnolog of YNR034W) SOL2 Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
LALA0_S02e06942g	similar to uniprot|Q6B1Q1 Saccharomyces cerevisiae YNR033W ABZ1 Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis
LALA0_S02e06964g	highly similar to uniprot|Q6Q546 Saccharomyces cerevisiae YNR032C-A HUB1 Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
LALA0_S02e06986g	highly similar to uniprot|P32838 Saccharomyces cerevisiae YNR032W PPG1 Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
LALA0_S02e07008g	similar to uniprot|P25390 Saccharomyces cerevisiae YCR073C (ohnolog of YNR031C) SSK22 MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p
LALA0_S02e07030g	highly similar to uniprot|P25382 Saccharomyces cerevisiae YCR072C RSA4 WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
LALA0_S02e07052g	similar to uniprot|P25642 Saccharomyces cerevisiae YCR071C IMG2 Mitochondrial ribosomal protein of the large subunit
LALA0_S02e07074g	similar to uniprot|P53730 Saccharomyces cerevisiae YNR030W ALG12 Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
LALA0_S02e07096g	similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Putative protein of unknown function, deletion confers reduced fitness in saline
LALA0_S02e07118g	similar to uniprot|P25334 Saccharomyces cerevisiae YCR069W (ohnolog of YNR028W) CPR4 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
LALA0_S02e07140g	weakly similar to uniprot|Q04411 Saccharomyces cerevisiae YDR520C URC2 Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
LALA0_S02e07162g	similar to uniprot|P25641 Saccharomyces cerevisiae YCR068W ATG15 Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
LALA0_S02e07184g	similar to uniprot|P53727 Saccharomyces cerevisiae YNR027W BUD17 Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)
LALA0_S02e07206g	some similarities with uniprot|P25365 Saccharomyces cerevisiae YCR067C (ohnolog of YNR026C) SED4 Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p
LALA0_S02e07228g	similar to uniprot|P10862 Saccharomyces cerevisiae YCR066W RAD18 E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair
LALA0_S02e07250g	weakly similar to uniprot|P25364 Saccharomyces cerevisiae YCR065W HCM1 Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role
LALA0_S02e07272g	highly similar to uniprot|P25337 Saccharomyces cerevisiae YCR063W BUD31 Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
LALA0_S02e07316g	similar to uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation
LALA0_S02e07338g	similar to uniprot|P25639 Saccharomyces cerevisiae YCR061W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation
LALA0_S02e07360g	similar to uniprot|P25637 Saccharomyces cerevisiae YCR059C YIH1 Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene
LALA0_S02e07382g	similar to uniprot|C5DBV3 Lachancea thermotolerans KLTH0A05610g hypothetical protein
LALA0_S02e07404g	highly similar to uniprot|P25636 Saccharomyces cerevisiae YCR057C PWP2 Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis
LALA0_S02e07426g	similar to uniprot|P25355 Saccharomyces cerevisiae YCR054C CTR86 Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels
LALA0_S02e07448g	highly similar to uniprot|P16120 Saccharomyces cerevisiae YCR053W THR4 Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
LALA0_S02e07470g	similar to uniprot|P25632 Saccharomyces cerevisiae YCR052W (ohnolog of YNR023W) RSC6 Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
LALA0_S02e07492g	similar to uniprot|P53724 Saccharomyces cerevisiae YNR022C MRPL50 Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
LALA0_S02e07514g	similar to uniprot|P53723 Saccharomyces cerevisiae YNR021W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene
LALA0_S02e07536g	similar to uniprot|P25631 Saccharomyces cerevisiae YCR051W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
LALA0_S02e07558g	similar to uniprot|P53722 Saccharomyces cerevisiae YNR020C ATP23 Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex
LALA0_S02e07580g	similar to uniprot|P25628 Saccharomyces cerevisiae YCR048W (ohnolog of YNR019W) ARE1 Acyl-CoA:sterolacyltransferase, isozyme of Are2p; endoplasmic reticulumenzyme that contributes the major sterol esterificationactivity in the absence of oxygen
LALA0_S02e07602g	highly similar to uniprot|P25627 Saccharomyces cerevisiae YCR047C BUD23 Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern
LALA0_S02e07624g	similar to uniprot|P25626 Saccharomyces cerevisiae YCR046C IMG1 Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
LALA0_S02e07646g	similar to uniprot|P53721 Saccharomyces cerevisiae YNR018W AIM38 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; may interact with respiratory chain complex IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss
LALA0_S02e07668g	similar to uniprot|P25381 Saccharomyces cerevisiae YCR045C RRT12 Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores
LALA0_S02e07690g	similar to uniprot|P32897 Saccharomyces cerevisiae YNR017W TIM23 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
LALA0_S02e07712g	highly similar to uniprot|Q00955 Saccharomyces cerevisiae YNR016C (ohnolog of YMR207C) ACC1 Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
LALA0_S02e07734g	similar to uniprot|P53720 Saccharomyces cerevisiae YNR015W SMM1 Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
LALA0_S02e07756g	weakly similar to uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4
LALA0_S02e07778g	weakly similar to uniprot|P53719 Saccharomyces cerevisiae YNR014W (ohnolog of YMR206W) Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
LALA0_S02e07800g	similar to uniprot|P27514 Saccharomyces cerevisiae YNR013C PHO91 Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
LALA0_S02e07822g	similar to uniprot|P27515 Saccharomyces cerevisiae YNR012W URK1 Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
LALA0_S02e07844g	similar to uniprot|P20095 Saccharomyces cerevisiae YNR011C PRP2 RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
LALA0_S02e07866g	similar to uniprot|P50107 Saccharomyces cerevisiae YML004C GLO1 Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress
LALA0_S02e07888g	highly similar to uniprot|P16862 Saccharomyces cerevisiae YMR205C PFK2 Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
LALA0_S02e07910g	weakly similar to uniprot|Q03694 Saccharomyces cerevisiae YMR204C INP1 Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane
LALA0_S02e07932g	highly similar to uniprot|P23644 Saccharomyces cerevisiae YMR203W TOM40 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
LALA0_S02e07954g	similar to uniprot|P33308 Saccharomyces cerevisiae YNR010W CSE2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity
LALA0_S02e07976g	highly similar to uniprot|P32352 Saccharomyces cerevisiae YMR202W ERG2 C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
LALA0_S02e07998g	weakly similar to uniprot|P53718 Saccharomyces cerevisiae YNR009W NRM1 Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
LALA0_S02e08020g	similar to uniprot|P40345 Saccharomyces cerevisiae YNR008W LRO1 Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
LALA0_S02e08042g	similar to uniprot|P40344 Saccharomyces cerevisiae YNR007C ATG3 E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt
LALA0_S02e08064g	similar to uniprot|P28519 Saccharomyces cerevisiae YMR201C RAD14 Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
LALA0_S02e08086g	similar to uniprot|P40343 Saccharomyces cerevisiae YNR006W VPS27 Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
LALA0_S02e08108g	similar to uniprot|Q03691 Saccharomyces cerevisiae YMR200W ROT1 Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations
LALA0_S02e08130g	similar to uniprot|P20438 Saccharomyces cerevisiae YPL256C (ohnolog of YMR199W) CLN2 G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
LALA0_S02e08152g	weakly similar to Lachancea thermotolerans KLTH0C10164g hypothetical protein
LALA0_S02e08174g	weakly similar to uniprot|Q12365 Saccharomyces cerevisiae YPL255W BBP1 Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
LALA0_S02e08196g	similar to uniprot|Q12060 Saccharomyces cerevisiae YPL254W HFI1 Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
LALA0_S02e08218g	weakly similar to uniprot|Q12045 Saccharomyces cerevisiae YPL253C (ohnolog of YMR198W) VIK1 Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p
LALA0_S02e08240g	similar to uniprot|Q12184 Saccharomyces cerevisiae YPL252C YAH1 Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
LALA0_S02e08262g	highly similar to uniprot|Q04338 Saccharomyces cerevisiae YMR197C VTI1 Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
LALA0_S02e08284g	highly similar to uniprot|Q04336 Saccharomyces cerevisiae YMR196W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
LALA0_S02e08306g	weakly similar to uniprot|Q04329 Saccharomyces cerevisiae YMR195W (ohnolog of YPL250C) ICY1 Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
LALA0_S02e08328g	similar to uniprot|G8ZSK1 Torulaspora delbrueckii TDEL0D00110 hypothetical protein
LALA0_S02e08350g	weakly similar to uniprot|Q03125 Saccharomyces cerevisiae YDR043C (ohnolog of YBR066C) NRG1 Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
LALA0_S02e08372g	weakly similar to uniprot|C5DE93 Lachancea thermotolerans KLTH0C07282g hypothetical protein
LALA0_S02e08394g	highly similar to uniprot|P11353 Saccharomyces cerevisiae YDR044W HEM13 Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
LALA0_S02e08416g	highly similar to uniprot|Q04307 Saccharomyces cerevisiae YDR045C RPC11 RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
LALA0_S02e08438g	similar to uniprot|P32833 Saccharomyces cerevisiae YBR060C ORC2 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p
LALA0_S02e08460g	weakly similar to uniprot|P38080 Saccharomyces cerevisiae YBR059C AKL1 Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization
LALA0_S02e08482g	similar to uniprot|Q3E790 Saccharomyces cerevisiae YBR058C-A TSC3 Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
LALA0_S02e08504g	highly similar to uniprot|C5DE93 Lachancea thermotolerans KLTH0C07282g hypothetical protein
LALA0_S02e08526g	similar to uniprot|P28817 Saccharomyces cerevisiae YDR036C EHD3 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
LALA0_S02e08548g	similar to uniprot|P38237 Saccharomyces cerevisiae YBR058C UBP14 Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T
LALA0_S02e08570g	weakly similar to uniprot|P38236 Saccharomyces cerevisiae YBR057C MUM2 Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
LALA0_S02e08592g	highly similar to uniprot|P14843 Saccharomyces cerevisiae YDR035W ARO3 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
LALA0_S02e08636g	similar to uniprot|P38081 Saccharomyces cerevisiae YBR056W Putative cytoplasmic protein of unknown function
LALA0_S02e08658g	similar to uniprot|P38235 Saccharomyces cerevisiae YBR053C Putative protein of unknown function; induced by cell wall perturbation
LALA0_S02e08680g	weakly similar to uniprot|P38767 Saccharomyces cerevisiae YHR032W ERC1 Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine
LALA0_S02e08702g	weakly similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
LALA0_S02e08724g	similar to uniprot|P40971 Saccharomyces cerevisiae YDR034C LYS14 Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
LALA0_S02e08746g	similar to uniprot|P19735 Saccharomyces cerevisiae YBR055C PRP6 Splicing factor, component of the U4/U6-U5 snRNP complex
LALA0_S02e08768g	highly similar to uniprot|Q12335 Saccharomyces cerevisiae YDR032C (ohnolog of YBR052C) PST2 Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S02e08790g	similar to uniprot|Q07789 Saccharomyces cerevisiae YDR031W MIC14 Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs
LALA0_S02e08812g	hypothetical protein
LALA0_S02e08834g	similar to uniprot|Q12021 Saccharomyces cerevisiae YDR030C RAD28 Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
LALA0_S02e08856g	similar to uniprot|P38232 Saccharomyces cerevisiae YBR050C (ohnolog of YDR028C) REG2 Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
LALA0_S02e08878g	similar to uniprot|Q12071 Saccharomyces cerevisiae YDR027C VPS54 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p
LALA0_S02e08900g	weakly similar to uniprot|Q12457 Saccharomyces cerevisiae YDR026C (ohnolog of YBR049C) Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p
LALA0_S02e08922g	highly similar to uniprot|P0CX47 Saccharomyces cerevisiae YDR025W (ohnolog of YBR048W) RPS11A Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
LALA0_S02e08944g	weakly similar to uniprot|P38229 Saccharomyces cerevisiae YBR045C GIP1 Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
LALA0_S02e08966g	highly similar to uniprot|P07284 Saccharomyces cerevisiae YDR023W SES1 Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
LALA0_S02e09010g	weakly similar to uniprot|Q03939 Saccharomyces cerevisiae YDR022C CIS1 Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
LALA0_S02e09032g	highly similar to uniprot|Q12099 Saccharomyces cerevisiae YDR021W FAL1 Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
LALA0_S02e09054g	similar to uniprot|Q12084 Saccharomyces cerevisiae YDR020C DAS2 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
LALA0_S02e09076g	similar to uniprot|P38228 Saccharomyces cerevisiae YBR044C TCM62 Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
LALA0_S02e09098g	similar to uniprot|P48015 Saccharomyces cerevisiae YDR019C GCV1 T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
LALA0_S02e09120g	highly similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
LALA0_S02e09142g	similar to uniprot|P38227 Saccharomyces cerevisiae YBR043C QDR3 Multidrug transporter of the major facilitator superfamily, has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
LALA0_S02e09164g	similar to uniprot|Q12185 Saccharomyces cerevisiae YDR018C (ohnolog of YBR042C) Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase
LALA0_S02e09186g	similar to uniprot|P38225 Saccharomyces cerevisiae YBR041W FAT1 Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids
LALA0_S02e09208g	similar to uniprot|P38224 Saccharomyces cerevisiae YBR040W FIG1 Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
LALA0_S02e09230g	similar to uniprot|P38077 Saccharomyces cerevisiae YBR039W ATP3 Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
LALA0_S02e09252g	similar to uniprot|Q7LGR2 Saccharomyces cerevisiae YDR017C KCS1 Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
LALA0_S02e09274g	similar to uniprot|Q12248 Saccharomyces cerevisiae YDR016C DAD1 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
LALA0_S02e09318g	weakly similar to uniprot|C5DED9 Lachancea thermotolerans KLTH0C08404g hypothetical protein
LALA0_S02e09340g	similar to uniprot|Q08913 Saccharomyces cerevisiae YOR390W Putative protein of unknown function
LALA0_S02e09362g	highly similar to uniprot|P38075 Saccharomyces cerevisiae YBR035C PDX3 Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
LALA0_S02e09384g	weakly similar to uniprot|Q99359 Saccharomyces cerevisiae YDR014W RAD61 Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin
LALA0_S02e09406g	highly similar to uniprot|Q12488 Saccharomyces cerevisiae YDR013W PSF1 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
LALA0_S02e09428g	similar to uniprot|P23369 Saccharomyces cerevisiae YGR076C MRPL25 Mitochondrial ribosomal protein of the large subunit
LALA0_S02e09450g	similar to uniprot|Q00723 Saccharomyces cerevisiae YGR075C PRP38 Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly
LALA0_S02e09472g	similar to uniprot|Q02260 Saccharomyces cerevisiae YGR074W SMD1 Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1
LALA0_S02e09494g	similar to Lachancea thermotolerans KLTH0C08624g hypothetical protein
LALA0_S02e09516g	weakly similar to uniprot|P48412 Saccharomyces cerevisiae YGR072W UPF3 Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
LALA0_S02e09538g	similar to uniprot|Q08231 Saccharomyces cerevisiae YOL072W THP1 Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
LALA0_S02e09560g	highly similar to uniprot|P20604 Saccharomyces cerevisiae YDL047W SIT4 Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
LALA0_S02e09582g	similar to uniprot|Q12408 Saccharomyces cerevisiae YDL046W NPC2 Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes
LALA0_S02e09604g	similar to uniprot|Q08230 Saccharomyces cerevisiae YOL071W EMI5 Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
LALA0_S02e09626g	highly similar to uniprot|O75012 Saccharomyces cerevisiae YDL045W-A MRP10 Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs
LALA0_S02e09648g	similar to uniprot|P38913 Saccharomyces cerevisiae YDL045C FAD1 Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
LALA0_S02e09670g	weakly similar to uniprot|P10849 Saccharomyces cerevisiae YDL044C MTF2 Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription
LALA0_S02e09692g	weakly similar to uniprot|Q08229 Saccharomyces cerevisiae YOL070C NBA1 Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate
LALA0_S02e09714g	similar to uniprot|C5DIT1 Lachancea thermotolerans KLTH0E14938g hypothetical protein
LALA0_S02e09736g	similar to uniprot|P33895 Saccharomyces cerevisiae YOL069W NUF2 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
LALA0_S02e09758g	similar to uniprot|Q07350 Saccharomyces cerevisiae YDL043C PRP11 Subunit of the SF3a splicing factor complex, required for spliceosome assembly
LALA0_S02e09780g	similar to uniprot|P06700 Saccharomyces cerevisiae YDL042C (ohnolog of YOL068C) SIR2 Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication
LALA0_S02e09802g	similar to uniprot|P32607 Saccharomyces cerevisiae YOL067C RTG1 Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus
LALA0_S02e09824g	similar to uniprot|P12945 Saccharomyces cerevisiae YDL040C NAT1 Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
LALA0_S02e09846g	similar to uniprot|Q12069 Saccharomyces cerevisiae YDL036C (ohnolog of YOL066C) PUS9 Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence
LALA0_S02e09868g	weakly similar to uniprot|Q08227 Saccharomyces cerevisiae YOL065C INP54 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
LALA0_S02e09890g	similar to uniprot|Q12361 Saccharomyces cerevisiae YDL035C GPR1 Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
LALA0_S02e09912g	weakly similar to uniprot|M2N9U1 Baudoinia compniacensis BAUCODRAFT_24881 hypothetical protein
LALA0_S02e09934g	similar to uniprot|P32179 Saccharomyces cerevisiae YOL064C MET22 Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
LALA0_S02e09956g	similar to uniprot|Q12093 Saccharomyces cerevisiae YDL033C SLM3 tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
LALA0_S02e09978g	highly similar to uniprot|Q12389 Saccharomyces cerevisiae YDL031W DBP10 Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
LALA0_S02e10000g	similar to uniprot|P19736 Saccharomyces cerevisiae YDL030W PRP9 Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
LALA0_S02e10022g	similar to uniprot|P38221 Saccharomyces cerevisiae YBR029C CDS1 Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
LALA0_S02e10044g	weakly similar to Lachancea thermotolerans KLTH0C08954g hypothetical protein
LALA0_S02e10066g	similar to uniprot|P38070 Saccharomyces cerevisiae YBR028C YPK3 An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner
LALA0_S02e10088g	similar to uniprot|C5DEI6 Lachancea thermotolerans KLTH0C09526g hypothetical protein
LALA0_S02e10110g	weakly similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
LALA0_S02e10132g	similar to uniprot|P38071 Saccharomyces cerevisiae YBR026C ETR1 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis
LALA0_S02e10154g	similar to uniprot|P35206 Saccharomyces cerevisiae YBR036C CSG2 Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations
LALA0_S02e10198g	weakly similar to uniprot|P13902 Saccharomyces cerevisiae YOL108C INO4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain
LALA0_S02e10242g	similar to uniprot|P36520 Saccharomyces cerevisiae YNL284C MRPL10 Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
LALA0_S02e10286g	weakly similar to uniprot|Q12215 Saccharomyces cerevisiae YOL105C (ohnolog of YNL283C) WSC3 Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis
LALA0_S02e10308g	similar to uniprot|P53833 Saccharomyces cerevisiae YNL282W POP3 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
LALA0_S02e10330g	similar to uniprot|P53834 Saccharomyces cerevisiae YNL281W HCH1 Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus
LALA0_S02e10352g	highly similar to uniprot|P32462 Saccharomyces cerevisiae YNL280C ERG24 C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
LALA0_S02e10374g	weakly similar to uniprot|Q12366 Saccharomyces cerevisiae YOL104C NDJ1 Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
LALA0_S02e10396g	weakly similar to uniprot|P28791 Saccharomyces cerevisiae YDR498C SEC20 Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p
LALA0_S02e10418g	similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C (ohnolog of YOL103W) ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
LALA0_S02e10440g	similar to uniprot|Q04373 Saccharomyces cerevisiae YDR496C PUF6 Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis
LALA0_S02e10462g	weakly similar to uniprot|P23643 Saccharomyces cerevisiae YDR495C VPS3 Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
LALA0_S02e10484g	weakly similar to uniprot|Q8X185 Saccharomyces cerevisiae YDR494W RSM28 Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation
LALA0_S02e10506g	similar to uniprot|Q12272 Saccharomyces cerevisiae YOL102C TPT1 tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
LALA0_S02e10528g	similar to uniprot|Q03429 Saccharomyces cerevisiae YDR493W MZM1 Mitochondrial matrix protein with a role in maintaining the labile mitochondrial zinc pool; null mutant has a respiratory growth defect and an elevated frequency of mitochondrial genome loss; overexpression causes cell cycle delay or arrest
LALA0_S02e10550g	similar to uniprot|Q6Q557 Saccharomyces cerevisiae YDR492W (ohnolog of YOL101C) IZH1 Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
LALA0_S02e10572g	weakly similar to uniprot|C5DEI6 Lachancea thermotolerans KLTH0C09526g hypothetical protein
LALA0_S02e10594g	weakly similar to uniprot|Q03407 Saccharomyces cerevisiae YDR490C (ohnolog of YOL100W) PKH1 Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
LALA0_S02e10616g	similar to uniprot|Q12496 Saccharomyces cerevisiae YOL098C Putative metalloprotease
LALA0_S02e10638g	hypothetical protein
LALA0_S02e10660g	weakly similar to uniprot|P38195 Saccharomyces cerevisiae YBL043W (ohnolog of YJR115W) ECM13 Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
LALA0_S02e10682g	similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
LALA0_S02e10704g	highly similar to uniprot|P23724 Saccharomyces cerevisiae YBL041W PRE7 Beta 6 subunit of the 20S proteasome
LALA0_S02e10726g	similar to uniprot|P18414 Saccharomyces cerevisiae YBL040C ERD2 HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
LALA0_S02e10748g	weakly similar to Lachancea thermotolerans KLTH0E02024g hypothetical protein
LALA0_S02e10770g	similar to uniprot|P0C268 Saccharomyces cerevisiae YBL039W-B Putative protein of unknown function
LALA0_S02e10792g	similar to uniprot|P00445 Saccharomyces cerevisiae YJR104C SOD1 Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
LALA0_S02e10814g	highly similar to uniprot|P28274 Saccharomyces cerevisiae YBL039C (ohnolog of YJR103W) URA7 Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
LALA0_S02e10836g	weakly similar to uniprot|Q12262 Saccharomyces cerevisiae YPR046W MCM16 Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA
LALA0_S02e10858g	similar to uniprot|P47142 Saccharomyces cerevisiae YJR102C VPS25 Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
LALA0_S02e10880g	similar to uniprot|P47141 Saccharomyces cerevisiae YJR101W RSM26 Mitochondrial ribosomal protein of the small subunit
LALA0_S02e10902g	similar to uniprot|P47140 Saccharomyces cerevisiae YJR100C AIM25 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss
LALA0_S02e10924g	highly similar to uniprot|L2FAP4 Colletotrichum gloeosporioides CGGC5_14858 3-carboxymuconate cyclase
LALA0_S02e10946g	weakly similar to uniprot|Q07109 Saccharomyces cerevisiae YPR045C THP3 Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
LALA0_S02e10968g	similar to uniprot|P35127 Saccharomyces cerevisiae YJR099W YUH1 Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
LALA0_S02e10990g	similar to uniprot|P40993 Saccharomyces cerevisiae YDR478W SNM1 Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
LALA0_S02e11012g	similar to uniprot|Q03370 Saccharomyces cerevisiae YDR479C PEX29 Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
LALA0_S02e11034g	similar to uniprot|P26449 Saccharomyces cerevisiae YOR026W BUB3 Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
LALA0_S02e11056g	similar to uniprot|Q07015 Saccharomyces cerevisiae YDR257C RKM4 Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
LALA0_S02e11078g	highly similar to uniprot|P15705 Saccharomyces cerevisiae YOR027W STI1 Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
LALA0_S02e11100g	highly similar to uniprot|P33416 Saccharomyces cerevisiae YDR258C HSP78 Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
LALA0_S02e11122g	weakly similar to uniprot|Q03935 Saccharomyces cerevisiae YDR259C (ohnolog of YOR028C) YAP6 Putative basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism
LALA0_S02e11166g	weakly similar to uniprot|P40103 Saccharomyces cerevisiae YER188W Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p
LALA0_S02e11188g	weakly similar to uniprot|J8TQE5 Saccharomyces cerevisiae YIL080W TyB Gag-Pol protein; proteolytically processed to make the Gag, RT, PR, and IN proteins that are required for retrotransposition
LALA0_S02e11232g	similar to uniprot|P40210 Saccharomyces cerevisiae YMR140W SIP5 Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase
LALA0_S02e11254g	highly similar to uniprot|P05318 Saccharomyces cerevisiae YDL081C RPP1A Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
LALA0_S02e11276g	highly similar to uniprot|Q12690 Saccharomyces cerevisiae YDL082W (ohnolog of YMR142C) RPL13A Proteincomponent of the large (60S) ribosomal subunit, nearlyidentical to Rpl13Bp; not essential for viability; hassimilarity to rat L13 ribosomal protein
LALA0_S02e11298g	highly similar to uniprot|P0CX52 Saccharomyces cerevisiae YDL083C (ohnolog of YMR143W) RPS16B Proteincomponent of the small (40S) ribosomal subunit; identicalto Rps16Ap and has similarity to E. coli S9 and rat S16ribosomal proteins
LALA0_S02e11320g	weakly similar to uniprot|P40214 Saccharomyces cerevisiae YMR144W Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
LALA0_S02e11342g	highly similar to uniprot|Q07478 Saccharomyces cerevisiae YDL084W SUB2 Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
LALA0_S02e11364g	similar to uniprot|Q07500 Saccharomyces cerevisiae YDL085W (ohnolog of YMR145C) NDE2 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
LALA0_S02e11386g	highly similar to uniprot|P40217 Saccharomyces cerevisiae YMR146C TIF34 eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation
LALA0_S02e11408g	highly similar to uniprot|Q07505 Saccharomyces cerevisiae YDL086W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
LALA0_S02e11430g	weakly similar to uniprot|Q03083 Saccharomyces cerevisiae YPL034W Putative protein of unknown function; YPL034W is not essential gene
LALA0_S02e11452g	some similarities with uniprot|P40219 Saccharomyces cerevisiae YMR148W OSW5 Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
LALA0_S02e11474g	weakly similar to uniprot|Q02795 Saccharomyces cerevisiae YMR149W SWP1 Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
LALA0_S02e11496g	similar to uniprot|P28627 Saccharomyces cerevisiae YMR150C IMP1 Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
LALA0_S02e11518g	similar to uniprot|Q07508 Saccharomyces cerevisiae YDL087C LUC7 Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA
LALA0_S02e11540g	weakly similar to uniprot|Q05166 Saccharomyces cerevisiae YDL088C (ohnolog of YMR153W) ASM4 Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p
LALA0_S02e11562g	weakly similar to uniprot|Q12066 Saccharomyces cerevisiae YDL089W NUR1 Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate
LALA0_S02e11584g	weakly similar to uniprot|Q03792 Saccharomyces cerevisiae YMR154C RIM13 Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB
LALA0_S02e11606g	similar to uniprot|P38735 Saccharomyces cerevisiae YHL035C (ohnolog of YLL048C) VMR1 Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions
LALA0_S03e00100g	similar to uniprot|P48510 Saccharomyces cerevisiae YMR276W DSK2 Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome
LALA0_S03e00122g	weakly similar to uniprot|Q03750 Saccharomyces cerevisiae YML114C TAF8 TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
LALA0_S03e00144g	similar to uniprot|Q03254 Saccharomyces cerevisiae YMR277W FCP1 Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
LALA0_S03e00166g	similar to uniprot|Q03262 Saccharomyces cerevisiae YMR278W PGM3 Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
LALA0_S03e00188g	highly similar to uniprot|Q12525 Saccharomyces cerevisiae YLL062C (ohnolog of YPL273W) MHT1 S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
LALA0_S03e00210g	similar to uniprot|P23642 Saccharomyces cerevisiae YML115C VAN1 Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
LALA0_S03e00232g	similar to uniprot|Q03263 Saccharomyces cerevisiae YMR279C (ohnolog of YML116W) Putative boron transporterinvolved in boron efflux and resistance; overexpressionmutant but not null mutant displays boron tolerancephenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene;paralog of the efflux pump ATR1
LALA0_S03e00254g	weakly similar to uniprot|Q03735 Saccharomyces cerevisiae YML117W NAB6 Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
LALA0_S03e00276g	similar to uniprot|P39113 Saccharomyces cerevisiae YMR280C CAT8 Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
LALA0_S03e00298g	weakly similar to uniprot|P23797 Saccharomyces cerevisiae YMR281W GPI12 ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
LALA0_S03e00320g	weakly similar to uniprot|P22136 Saccharomyces cerevisiae YMR282C AEP2 Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
LALA0_S03e00342g	similar to uniprot|P23796 Saccharomyces cerevisiae YMR283C RIT1 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
LALA0_S03e00364g	similar to uniprot|P40484 Saccharomyces cerevisiae YIL106W MOB1 Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex
LALA0_S03e00386g	similar to uniprot|P53954 Saccharomyces cerevisiae YNL048W ALG11 Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER
LALA0_S03e00408g	similar to uniprot|P40485 Saccharomyces cerevisiae YIL105C (ohnolog of YNL047C) SLM1 Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex
LALA0_S03e00430g	similar to uniprot|C5DML8 Lachancea thermotolerans KLTH0G09966g hypothetical protein
LALA0_S03e00452g	similar to uniprot|Q10740 Saccharomyces cerevisiae YNL045W LAP2 Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
LALA0_S03e00474g	highly similar to uniprot|P53633 Saccharomyces cerevisiae YNL044W YIP3 Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
LALA0_S03e00496g	weakly similar to uniprot|P53958 Saccharomyces cerevisiae YNL042W BOP3 Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury
LALA0_S03e00518g	similar to uniprot|P40486 Saccharomyces cerevisiae YIL104C SHQ1 Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones
LALA0_S03e00540g	highly similar to uniprot|P40487 Saccharomyces cerevisiae YIL103W DPH1 Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p
LALA0_S03e00562g	similar to uniprot|P53959 Saccharomyces cerevisiae YNL041C COG6 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
LALA0_S03e00584g	weakly similar to uniprot|P40489 Saccharomyces cerevisiae YIL101C XBP1 Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
LALA0_S03e00606g	hypothetical protein
LALA0_S03e00628g	weakly similar to uniprot|P53174 Saccharomyces cerevisiae YGL053W PRM8 Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
LALA0_S03e00650g	similar to uniprot|P53615 Saccharomyces cerevisiae YNL036W NCE103 Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
LALA0_S03e00672g	weakly similar to uniprot|P08019 Saccharomyces cerevisiae YIL099W SGA1 Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
LALA0_S03e00694g	similar to uniprot|P40491 Saccharomyces cerevisiae YIL098C FMC1 Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
LALA0_S03e00716g	highly similar to uniprot|P28834 Saccharomyces cerevisiae YNL037C IDH1 Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
LALA0_S03e00738g	similar to uniprot|P40492 Saccharomyces cerevisiae YIL097W FYV10 Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosis
LALA0_S03e00760g	similar to uniprot|P40493 Saccharomyces cerevisiae YIL096C Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis
LALA0_S03e00782g	some similarities with uniprot|P53961 Saccharomyces cerevisiae YNL038W GPI15 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
LALA0_S03e00804g	similar to uniprot|P46678 Saccharomyces cerevisiae YNL039W BDP1 Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
LALA0_S03e00826g	similar to uniprot|P53962 Saccharomyces cerevisiae YNL035C Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
LALA0_S03e00848g	similar to uniprot|P40494 Saccharomyces cerevisiae YIL095W (ohnolog of YNL020C) PRK1 Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
LALA0_S03e00870g	highly similar to uniprot|P53973 Saccharomyces cerevisiae YNL021W HDA1 Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation
LALA0_S03e00892g	similar to uniprot|P53972 Saccharomyces cerevisiae YNL022C Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis
LALA0_S03e00914g	highly similar to uniprot|P40495 Saccharomyces cerevisiae YIL094C LYS12 Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
LALA0_S03e00936g	similar to uniprot|P53971 Saccharomyces cerevisiae YNL023C FAP1 Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1
LALA0_S03e00958g	similar to uniprot|P53970 Saccharomyces cerevisiae YNL024C Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene
LALA0_S03e00980g	similar to uniprot|P40496 Saccharomyces cerevisiae YIL093C RSM25 Mitochondrial ribosomal protein of the small subunit
LALA0_S03e01002g	highly similar to uniprot|Q8TGJ3 Saccharomyces cerevisiae YNL024C-A KSH1 Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; ortholog of human Kish
LALA0_S03e01024g	similar to uniprot|P40498 Saccharomyces cerevisiae YIL091C UTP25 Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis; contains a DEAD-box RNA helicase-like motif
LALA0_S03e01046g	similar to uniprot|P40499 Saccharomyces cerevisiae YIL090W ICE2 Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells
LALA0_S03e01068g	similar to uniprot|P47821 Saccharomyces cerevisiae YNL025C SSN8 Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance
LALA0_S03e01090g	weakly similar to uniprot|P38703 Saccharomyces cerevisiae YHL003C (ohnolog of YKL008C) LAG1 Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
LALA0_S03e01112g	similar to uniprot|P40501 Saccharomyces cerevisiae YIL088C AVT7 Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
LALA0_S03e01134g	similar to uniprot|P53965 Saccharomyces cerevisiae YNL032W SIW14 Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
LALA0_S03e01156g	similar to uniprot|P40502 Saccharomyces cerevisiae YIL087C AIM19 Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth
LALA0_S03e01178g	some similarities with uniprot|P02303 Saccharomyces cerevisiae YNL031C HHT2 Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
LALA0_S03e01200g	some similarities with uniprot|P02309 Saccharomyces cerevisiae YNL030W HHF2 Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
LALA0_S03e01222g	similar to uniprot|P40504 Saccharomyces cerevisiae YIL085C (ohnolog of YNL029C) KTR7 Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
LALA0_S03e01244g	similar to uniprot|P40505 Saccharomyces cerevisiae YIL084C SDS3 Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes
LALA0_S03e01266g	similar to uniprot|Q04235 Saccharomyces cerevisiae YML005W TRM12 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
LALA0_S03e01288g	weakly similar to uniprot|P53968 Saccharomyces cerevisiae YNL027W CRZ1 Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation
LALA0_S03e01310g	similar to uniprot|P53969 Saccharomyces cerevisiae YNL026W SAM50 Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
LALA0_S03e01332g	similar to uniprot|P40506 Saccharomyces cerevisiae YIL083C CAB2 Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
LALA0_S03e01376g	similar to uniprot|P32588 Saccharomyces cerevisiae YNL016W PUB1 Poly (A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly
LALA0_S03e01398g	similar to uniprot|P25037 Saccharomyces cerevisiae YDL122W UBP1 Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
LALA0_S03e01420g	similar to Lachancea thermotolerans KLTH0G11440g hypothetical protein
LALA0_S03e01442g	weakly similar to uniprot|Q07540 Saccharomyces cerevisiae YDL120W YFH1 Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
LALA0_S03e01464g	similar to uniprot|P01095 Saccharomyces cerevisiae YNL015W PBI2 Cytosolic inhibitor of vacuolar proteinase B (PRB1), required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion
LALA0_S03e01486g	highly similar to uniprot|P22855 Saccharomyces cerevisiae YGL156W AMS1 Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
LALA0_S03e01508g	similar to uniprot|P18898 Saccharomyces cerevisiae YGL155W CDC43 Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
LALA0_S03e01530g	similar to uniprot|Q07534 Saccharomyces cerevisiae YDL119C Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
LALA0_S03e01552g	similar to uniprot|P50113 Saccharomyces cerevisiae YGL154C LYS5 Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine
LALA0_S03e01574g	similar to uniprot|P53112 Saccharomyces cerevisiae YGL153W PEX14 Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p
LALA0_S03e01596g	similar to uniprot|P53114 Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
LALA0_S03e01618g	similar to uniprot|P53115 Saccharomyces cerevisiae YGL150C INO80 ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription
LALA0_S03e01640g	weakly similar to uniprot|P30605 Saccharomyces cerevisiae YDR497C (ohnolog of YOL103W) ITR1 Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
LALA0_S03e01662g	highly similar to uniprot|P52910 Saccharomyces cerevisiae YLR153C ACS2 Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
LALA0_S03e01684g	similar to uniprot|P54072 Saccharomyces cerevisiae YLR152C Putative protein of unknown function; YLR152C is not an essential gene
LALA0_S03e01706g	similar to uniprot|Q12524 Saccharomyces cerevisiae YLR151C PCD1 Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids
LALA0_S03e01728g	similar to uniprot|P39015 Saccharomyces cerevisiae YLR150W STM1 Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure
LALA0_S03e01750g	weakly similar to uniprot|Q12427 Saccharomyces cerevisiae YDR169C STB3 Ribosomal RNA processing element (RRPE)-binding protein involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p
LALA0_S03e01772g	similar to uniprot|Q99296 Saccharomyces cerevisiae YLR149C Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene
LALA0_S03e01794g	similar to uniprot|P06101 Saccharomyces cerevisiae YDR168W CDC37 Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
LALA0_S03e01816g	similar to uniprot|Q12030 Saccharomyces cerevisiae YDR167W TAF10 Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
LALA0_S03e01838g	similar to uniprot|P27801 Saccharomyces cerevisiae YLR148W PEP3 Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis
LALA0_S03e01860g	highly similar to uniprot|P43321 Saccharomyces cerevisiae YLR147C SMD3 Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3
LALA0_S03e01882g	similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W GRE2 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
LALA0_S03e01904g	similar to uniprot|P89102 Saccharomyces cerevisiae YDR166C SEC5 Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
LALA0_S03e01926g	weakly similar to uniprot|C5DMT9 Lachancea thermotolerans KLTH0G11572g hypothetical protein
LALA0_S03e01948g	similar to uniprot|Q03774 Saccharomyces cerevisiae YDR165W TRM82 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
LALA0_S03e01970g	similar to uniprot|Q12455 Saccharomyces cerevisiae YLR146C SPE4 Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
LALA0_S03e01992g	similar to uniprot|Q12530 Saccharomyces cerevisiae YLR145W RMP1 Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
LALA0_S03e02014g	similar to uniprot|Q07268 Saccharomyces cerevisiae YLR144C ACF2 Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly
LALA0_S03e02036g	similar to uniprot|P30619 Saccharomyces cerevisiae YDR164C SEC1 Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function
LALA0_S03e02058g	similar to uniprot|C5DL30 Lachancea thermotolerans KLTH0F09526g hypothetical protein
LALA0_S03e02080g	similar to uniprot|Q07261 Saccharomyces cerevisiae YLR143W Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene
LALA0_S03e02102g	similar to uniprot|P09368 Saccharomyces cerevisiae YLR142W PUT1 Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
LALA0_S03e02124g	weakly similar to uniprot|P42900 Saccharomyces cerevisiae YLR139C SLS1 Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
LALA0_S03e02146g	some similarities with uniprot|Q02983 Saccharomyces cerevisiae YLR141W RRN5 Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
LALA0_S03e02168g	similar to uniprot|Q03772 Saccharomyces cerevisiae YDR163W CWC15 Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p
LALA0_S03e02190g	weakly similar to uniprot|Q12163 Saccharomyces cerevisiae YDR162C NBP2 Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
LALA0_S03e02212g	similar to uniprot|Q03771 Saccharomyces cerevisiae YDR161W Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
LALA0_S03e02234g	similar to uniprot|Q03770 Saccharomyces cerevisiae YDR160W SSY1 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
LALA0_S03e02256g	similar to uniprot|Q99271 Saccharomyces cerevisiae YLR138W NHA1 Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
LALA0_S03e02278g	similar to uniprot|P46674 Saccharomyces cerevisiae YDR159W SAC3 Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
LALA0_S03e02300g	similar to uniprot|Q12367 Saccharomyces cerevisiae YLR137W RKM5 Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species
LALA0_S03e02322g	highly similar to uniprot|P13663 Saccharomyces cerevisiae YDR158W HOM2 Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
LALA0_S03e02344g	some similarities with uniprot|P50106 Saccharomyces cerevisiae YDR156W RPA14 RNA polymerase I subunit A14
LALA0_S03e02366g	highly similar to uniprot|P14832 Saccharomyces cerevisiae YDR155C CPR1 Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
LALA0_S03e02388g	similar to uniprot|Q6Q5U2 Saccharomyces cerevisiae YDR153C ENT5 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
LALA0_S03e02410g	similar to uniprot|Q03768 Saccharomyces cerevisiae YDR152W GIR2 Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein
LALA0_S03e02432g	weakly similar to uniprot|P47976 Saccharomyces cerevisiae YDR151C (ohnolog of YLR136C) CTH1 Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis
LALA0_S03e02454g	weakly similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70 Protein of unknown function involved in vacuolar protein sorting
LALA0_S03e02476g	weakly similar to uniprot|Q00402 Saccharomyces cerevisiae YDR150W NUM1 Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
LALA0_S03e02498g	weakly similar to uniprot|Q12098 Saccharomyces cerevisiae YLR135W SLX4 Endonuclease involved in processing DNA during recombination and repair; cleaves branched structures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing
LALA0_S03e02520g	similar to uniprot|Q6B312 Saccharomyces cerevisiae YDL237W AIM6 Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
LALA0_S03e02564g	similar to uniprot|P41812 Saccharomyces cerevisiae YNL221C POP1 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
LALA0_S03e02586g	similar to uniprot|Q05998 Saccharomyces cerevisiae YLR237W THI7 Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
LALA0_S03e02608g	similar to uniprot|O13525 Saccharomyces cerevisiae YDR204W COQ4 Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
LALA0_S03e02630g	similar to uniprot|Q03956 Saccharomyces cerevisiae YDR202C RAV2 Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
LALA0_S03e02652g	similar to uniprot|Q03954 Saccharomyces cerevisiae YDR201W SPC19 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
LALA0_S03e02674g	similar to uniprot|Q03944 Saccharomyces cerevisiae YDR200C (ohnolog of YLR238W) VPS64 Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance
LALA0_S03e02696g	similar to uniprot|Q06005 Saccharomyces cerevisiae YLR239C LIP2 Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups
LALA0_S03e02718g	similar to uniprot|Q03942 Saccharomyces cerevisiae YDR198C RKM2 Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp
LALA0_S03e02740g	weakly similar to uniprot|P14905 Saccharomyces cerevisiae YDR197W CBS2 Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
LALA0_S03e02762g	similar to uniprot|Q03941 Saccharomyces cerevisiae YDR196C CAB5 Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies
LALA0_S03e02784g	similar to uniprot|P42073 Saccharomyces cerevisiae YDR195W REF2 RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
LALA0_S03e02806g	similar to uniprot|P15424 Saccharomyces cerevisiae YDR194C MSS116 DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
LALA0_S03e02828g	similar to uniprot|P22543 Saccharomyces cerevisiae YLR240W VPS34 Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p
LALA0_S03e02850g	similar to uniprot|Q06538 Saccharomyces cerevisiae YLR241W Putative protein of unknown function, may be involved in detoxification
LALA0_S03e02872g	similar to uniprot|Q2VQX3 Saccharomyces cerevisiae YLR242C ARV1 Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p
LALA0_S03e02894g	weakly similar to uniprot|P49686 Saccharomyces cerevisiae YDR192C NUP42 Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p
LALA0_S03e02916g	highly similar to uniprot|Q06543 Saccharomyces cerevisiae YLR243W Putative protein of unknown function; YLR243W is an essential gene
LALA0_S03e02938g	similar to uniprot|P53688 Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
LALA0_S03e02960g	highly similar to uniprot|Q03940 Saccharomyces cerevisiae YDR190C RVB1 Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as pontin; member of the RUVB-like protein family
LALA0_S03e02982g	similar to uniprot|P22213 Saccharomyces cerevisiae YDR189W SLY1 Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
LALA0_S03e03004g	highly similar to uniprot|P39079 Saccharomyces cerevisiae YDR188W CCT6 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
LALA0_S03e03026g	highly similar to uniprot|Q01662 Saccharomyces cerevisiae YLR244C MAP1 Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
LALA0_S03e03048g	similar to uniprot|Q06549 Saccharomyces cerevisiae YLR245C CDD1 Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm
LALA0_S03e03070g	weakly similar to uniprot|Q04007 Saccharomyces cerevisiae YDR186C Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S03e03092g	similar to uniprot|Q6B217 Saccharomyces cerevisiae YLR246W ERF2 Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole
LALA0_S03e03114g	similar to uniprot|Q04006 Saccharomyces cerevisiae YDR185C (ohnolog of YLR168C) UPS3 Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations
LALA0_S03e03136g	weakly similar to uniprot|Q6Q540 Saccharomyces cerevisiae YDR184C ATC1 Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern
LALA0_S03e03158g	highly similar to uniprot|P61864 Saccharomyces cerevisiae YLR167W RPS31 Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
LALA0_S03e03180g	similar to uniprot|Q04004 Saccharomyces cerevisiae YDR183W PLP1 Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators
LALA0_S03e03202g	similar to uniprot|Q06245 Saccharomyces cerevisiae YLR166C SEC10 Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
LALA0_S03e03224g	similar to uniprot|P40986 Saccharomyces cerevisiae YDR182W CDC1 Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution
LALA0_S03e03246g	weakly similar to uniprot|Q04003 Saccharomyces cerevisiae YDR181C SAS4 Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
LALA0_S03e03268g	similar to uniprot|Q04002 Saccharomyces cerevisiae YDR180W SCC2 Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin
LALA0_S03e03290g	similar to uniprot|Q06244 Saccharomyces cerevisiae YLR165C PUS5 Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
LALA0_S03e03312g	similar to uniprot|Q03984 Saccharomyces cerevisiae YDR179W-A Putative protein of unknown function
LALA0_S03e03334g	similar to uniprot|Q03981 Saccharomyces cerevisiae YDR179C CSN9 Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
LALA0_S03e03356g	similar to uniprot|P37298 Saccharomyces cerevisiae YDR178W (ohnolog of YLR164W) SDH4 Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
LALA0_S03e03378g	highly similar to uniprot|P10507 Saccharomyces cerevisiae YLR163C MAS1 Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
LALA0_S03e03400g	similar to uniprot|P32494 Saccharomyces cerevisiae YDR176W NGG1 Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
LALA0_S03e03422g	similar to uniprot|Q03976 Saccharomyces cerevisiae YDR175C RSM24 Mitochondrial ribosomal protein of the small subunit
LALA0_S03e03444g	highly similar to uniprot|Q03973 Saccharomyces cerevisiae YDR174W HMO1 Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
LALA0_S03e03466g	similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
LALA0_S03e03488g	similar to uniprot|P07250 Saccharomyces cerevisiae YDR173C ARG82 Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
LALA0_S03e03510g	similar to uniprot|P05453 Saccharomyces cerevisiae YDR172W SUP35 Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
LALA0_S03e03532g	similar to uniprot|Q12329 Saccharomyces cerevisiae YDR171W HSP42 Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
LALA0_S03e03554g	highly similar to Lachancea thermotolerans KLTH0F09174g hypothetical protein
LALA0_S03e03576g	similar to uniprot|P11075 Saccharomyces cerevisiae YDR170C SEC7 Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
LALA0_S03e03598g	highly similar to uniprot|P28777 Saccharomyces cerevisiae YGL148W ARO2 Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
LALA0_S03e03620g	similar to uniprot|Q07533 Saccharomyces cerevisiae YDL117W CYK3 SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis
LALA0_S03e03642g	similar to uniprot|P52891 Saccharomyces cerevisiae YDL116W NUP84 Subunit of the nuclear pore complex (NPC); forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export, and NPC biogenesis; required also for transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
LALA0_S03e03664g	highly similar to uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins
LALA0_S03e03686g	similar to uniprot|A2TBP4 Saccharomyces cerevisiae YDL115C IWR1 RNA polymerase II transport factor, conserved from yeast to humans; involved in both basal and regulated transcription from RNA polymerase II (RNAP II) promoters, but not itself a transcription factor; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin
LALA0_S03e03708g	similar to uniprot|Q07528 Saccharomyces cerevisiae YDL113C ATG20 Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
LALA0_S03e03730g	similar to uniprot|Q7LGS3 Saccharomyces cerevisiae YDL112W TRM3 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
LALA0_S03e03752g	similar to uniprot|Q12277 Saccharomyces cerevisiae YDL111C RRP42 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
LALA0_S03e03774g	weakly similar to uniprot|P53117 Saccharomyces cerevisiae YGL146C RRT6 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
LALA0_S03e03796g	similar to uniprot|Q12513 Saccharomyces cerevisiae YDL110C TMA17 Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
LALA0_S03e03818g	similar to uniprot|P33891 Saccharomyces cerevisiae YGL145W TIP20 Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p
LALA0_S03e03840g	similar to uniprot|P53118 Saccharomyces cerevisiae YGL144C (ohnolog of YDL109C) ROG1 Protein with putative serine active lipase domain
LALA0_S03e03862g	similar to uniprot|P30775 Saccharomyces cerevisiae YGL143C MRF1 Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
LALA0_S03e03884g	highly similar to uniprot|P06242 Saccharomyces cerevisiae YDL108W KIN28 Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
LALA0_S03e03906g	similar to uniprot|C5DL30 Lachancea thermotolerans KLTH0F09526g hypothetical protein
LALA0_S03e03928g	similar to uniprot|P40990 Saccharomyces cerevisiae YDL107W MSS2 Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
LALA0_S03e03950g	similar to uniprot|P30777 Saccharomyces cerevisiae YGL142C GPI10 Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog
LALA0_S03e03972g	similar to uniprot|P53119 Saccharomyces cerevisiae YGL141W HUL5 Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
LALA0_S03e03994g	similar to uniprot|Q03212 Saccharomyces cerevisiae YMR171C EAR1 Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p
LALA0_S03e04016g	similar to uniprot|P07269 Saccharomyces cerevisiae YDL106C PHO2 Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p
LALA0_S03e04038g	similar to uniprot|P47771 Saccharomyces cerevisiae YMR170C ALD2 Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
LALA0_S03e04060g	highly similar to uniprot|P47771 Saccharomyces cerevisiae YMR170C ALD2 Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
LALA0_S03e04082g	similar to uniprot|P40969 Saccharomyces cerevisiae YMR168C CEP3 Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
LALA0_S03e04104g	similar to uniprot|Q2I041 Saccharomyces cerevisiae YMR167W MLH1 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
LALA0_S03e04126g	similar to uniprot|P43124 Saccharomyces cerevisiae YDL105W NSE4 Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex
LALA0_S03e04148g	similar to uniprot|P43122 Saccharomyces cerevisiae YDL104C QRI7 Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification
LALA0_S03e04170g	similar to uniprot|Q03829 Saccharomyces cerevisiae YMR166C Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
LALA0_S03e04192g	similar to uniprot|P32567 Saccharomyces cerevisiae YMR165C PAH1 Mg<sup>2+</sup>-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol, responsible for de novo lipid synthesis and formation of lipid droplets; homologous to mammalian lipin 1
LALA0_S03e04214g	weakly similar to uniprot|Q03825 Saccharomyces cerevisiae YMR164C MSS11 Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals
LALA0_S03e04236g	weakly similar to uniprot|Q03824 Saccharomyces cerevisiae YMR163C INP2 Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene
LALA0_S03e04258g	similar to uniprot|P43123 Saccharomyces cerevisiae YDL103C QRI1 UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis
LALA0_S03e04280g	similar to uniprot|Q12674 Saccharomyces cerevisiae YMR162C DNF3 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase
LALA0_S03e04302g	similar to uniprot|P48353 Saccharomyces cerevisiae YMR161W HLJ1 Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
LALA0_S03e04324g	hypothetical protein
LALA0_S03e04346g	highly similar to uniprot|P15436 Saccharomyces cerevisiae YDL102W POL3 Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
LALA0_S03e04368g	similar to uniprot|P39009 Saccharomyces cerevisiae YDL101C DUN1 Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
LALA0_S03e04390g	similar to uniprot|Q03823 Saccharomyces cerevisiae YMR160W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene
LALA0_S03e04412g	similar to uniprot|Q03818 Saccharomyces cerevisiae YMR159C ATG16 Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy
LALA0_S03e04456g	highly similar to uniprot|Q12154 Saccharomyces cerevisiae YDL100C GET3 Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity
LALA0_S03e04478g	similar to uniprot|Q12191 Saccharomyces cerevisiae YDL099W BUG1 Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
LALA0_S03e04500g	highly similar to uniprot|Q03799 Saccharomyces cerevisiae YMR158W MRPS8 Mitochondrial ribosomal protein of the small subunit
LALA0_S03e04522g	similar to uniprot|Q03798 Saccharomyces cerevisiae YMR157C AIM36 Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
LALA0_S03e04544g	similar to uniprot|Q12368 Saccharomyces cerevisiae YDL098C SNU23 Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome
LALA0_S03e04566g	similar to uniprot|Q03796 Saccharomyces cerevisiae YMR156C TPP1 DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily
LALA0_S03e04588g	highly similar to uniprot|Q12377 Saccharomyces cerevisiae YDL097C RPN6 Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion
LALA0_S03e04610g	similar to uniprot|P33775 Saccharomyces cerevisiae YDL095W PMT1 Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein Ser/Thr residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control
LALA0_S03e04632g	similar to uniprot|Q03795 Saccharomyces cerevisiae YMR155W Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
LALA0_S03e04654g	similar to uniprot|P38985 Saccharomyces cerevisiae YDL092W SRP14 Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
LALA0_S03e04676g	similar to uniprot|Q12229 Saccharomyces cerevisiae YDL091C UBX3 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S03e04698g	similar to uniprot|P22007 Saccharomyces cerevisiae YDL090C RAM1 Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
LALA0_S03e04720g	similar to uniprot|P10080 Saccharomyces cerevisiae YHL034C (ohnolog of YLL046C) SBP1 Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
LALA0_S03e04742g	highly similar to uniprot|P07702 Saccharomyces cerevisiae YBR115C LYS2 Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
LALA0_S03e04764g	highly similar to uniprot|P31244 Saccharomyces cerevisiae YBR114W RAD16 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
LALA0_S03e04786g	similar to uniprot|P14922 Saccharomyces cerevisiae YBR112C CYC8 General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]
LALA0_S03e04808g	similar to uniprot|Q6WNK7 Saccharomyces cerevisiae YBR111W-A SUS1 Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP
LALA0_S03e04830g	similar to uniprot|Q01976 Saccharomyces cerevisiae YBR111C YSA1 Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate
LALA0_S03e04852g	similar to uniprot|Q12321 Saccharomyces cerevisiae YPR070W MED1 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
LALA0_S03e04874g	highly similar to uniprot|Q12074 Saccharomyces cerevisiae YPR069C SPE3 Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
LALA0_S03e04896g	similar to uniprot|Q12214 Saccharomyces cerevisiae YPR068C HOS1 Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex
LALA0_S03e04918g	similar to uniprot|P16661 Saccharomyces cerevisiae YBR110W ALG1 Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
LALA0_S03e04940g	highly similar to uniprot|P06787 Saccharomyces cerevisiae YBR109C CMD1 Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
LALA0_S03e04962g	weakly similar to uniprot|P38266 Saccharomyces cerevisiae YBR108W AIM3 Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss
LALA0_S03e04984g	weakly similar to uniprot|P38265 Saccharomyces cerevisiae YBR107C IML3 Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p
LALA0_S03e05006g	similar to uniprot|Q12425 Saccharomyces cerevisiae YPR067W ISA2 Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations
LALA0_S03e05028g	similar to uniprot|Q99344 Saccharomyces cerevisiae YPR066W UBA3 Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S03e05050g	highly similar to uniprot|P38264 Saccharomyces cerevisiae YBR106W PHO88 Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
LALA0_S03e05072g	highly similar to uniprot|Q3E757 Saccharomyces cerevisiae YGR085C (ohnolog of YPR102C) RPL11B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
LALA0_S03e05094g	weakly similar to uniprot|Q06091 Saccharomyces cerevisiae YPR101W SNT309 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
LALA0_S03e05116g	similar to uniprot|P12686 Saccharomyces cerevisiae YGR084C MRP13 Mitochondrial ribosomal protein of the small subunit
LALA0_S03e05138g	weakly similar to uniprot|P18634 Saccharomyces cerevisiae YLR392C ART10 Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene
LALA0_S03e05160g	similar to uniprot|P12754 Saccharomyces cerevisiae YGR083C GCD2 Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
LALA0_S03e05182g	highly similar to uniprot|Q06090 Saccharomyces cerevisiae YPR100W MRPL51 Mitochondrial ribosomal protein of the large subunit
LALA0_S03e05204g	similar to uniprot|Q06089 Saccharomyces cerevisiae YPR098C Protein of unknown function, localized to the mitochondrial outer membrane
LALA0_S03e05226g	similar to uniprot|P35180 Saccharomyces cerevisiae YGR082W TOM20 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
LALA0_S03e05248g	similar to uniprot|P53251 Saccharomyces cerevisiae YGR081C SLX9 Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
LALA0_S03e05270g	similar to uniprot|Q06839 Saccharomyces cerevisiae YPR097W Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S03e05314g	weakly similar to uniprot|Q06836 Saccharomyces cerevisiae YPR095C SYT1 Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain
LALA0_S03e05336g	similar to uniprot|Q06835 Saccharomyces cerevisiae YPR094W RDS3 Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
LALA0_S03e05358g	weakly similar to uniprot|Q06834 Saccharomyces cerevisiae YPR093C ASR1 Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein
LALA0_S03e05380g	similar to uniprot|P53250 Saccharomyces cerevisiae YGR080W TWF1 Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly
LALA0_S03e05402g	similar to uniprot|C5DLC2 Lachancea thermotolerans KLTH0F11792g hypothetical protein
LALA0_S03e05424g	similar to uniprot|Q06833 Saccharomyces cerevisiae YPR091C Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the ER; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
LALA0_S03e05446g	similar to uniprot|P38111 Saccharomyces cerevisiae YBR136W MEC1 Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination
LALA0_S03e05468g	similar to uniprot|P20486 Saccharomyces cerevisiae YBR135W CKS1 Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters
LALA0_S03e05490g	similar to uniprot|P38274 Saccharomyces cerevisiae YBR133C HSL7 Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p
LALA0_S03e05512g	similar to uniprot|Q86ZS6 Saccharomyces cerevisiae YPR089W Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p
LALA0_S03e05534g	similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C AGP2 High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
LALA0_S03e05556g	similar to uniprot|P38273 Saccharomyces cerevisiae YBR131W CCZ1 Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway
LALA0_S03e05578g	highly similar to uniprot|P20424 Saccharomyces cerevisiae YPR088C SRP54 Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
LALA0_S03e05600g	weakly similar to uniprot|P38272 Saccharomyces cerevisiae YBR130C SHE3 Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
LALA0_S03e05622g	weakly similar to uniprot|P38271 Saccharomyces cerevisiae YBR129C OPY1 Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S03e05644g	similar to uniprot|Q06822 Saccharomyces cerevisiae YPR085C ASA1 Putative protein of unknown function; subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery
LALA0_S03e05666g	similar to uniprot|Q06821 Saccharomyces cerevisiae YPR084W Putative protein of unknown function
LALA0_S03e05688g	weakly similar to uniprot|P38270 Saccharomyces cerevisiae YBR128C ATG14 Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; homolog of human Barkor
LALA0_S03e05710g	highly similar to uniprot|P16140 Saccharomyces cerevisiae YBR127C VMA2 Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm
LALA0_S03e05732g	similar to uniprot|Q06820 Saccharomyces cerevisiae YPR083W MDM36 Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission
LALA0_S03e05754g	highly similar to uniprot|Q00764 Saccharomyces cerevisiae YBR126C TPS1 Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
LALA0_S03e05776g	similar to uniprot|P38089 Saccharomyces cerevisiae YBR125C PTC4 Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
LALA0_S03e05798g	similar to uniprot|P32367 Saccharomyces cerevisiae YBR123C TFC1 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63
LALA0_S03e05820g	highly similar to uniprot|P36531 Saccharomyces cerevisiae YBR122C MRPL36 Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region
LALA0_S03e05842g	highly similar to uniprot|Q06819 Saccharomyces cerevisiae YPR082C DIB1 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
LALA0_S03e05864g	highly similar to uniprot|P38088 Saccharomyces cerevisiae YBR121C (ohnolog of YPR081C) GRS1 Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
LALA0_S03e05886g	similar to uniprot|P07253 Saccharomyces cerevisiae YBR120C CBP6 Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
LALA0_S03e05908g	some similarities with uniprot|P32605 Saccharomyces cerevisiae YBR119W MUD1 U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing
LALA0_S03e05930g	highly similar to uniprot|P02994 Saccharomyces cerevisiae YBR118W (ohnolog of YPR080W) TEF2 Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus
LALA0_S03e05952g	similar to uniprot|Q06815 Saccharomyces cerevisiae YPR079W MRL1 Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases
LALA0_S03e05974g	similar to uniprot|Q07549 Saccharomyces cerevisiae YDL123W SNA4 Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated
LALA0_S03e06018g	similar to uniprot|C5DFF2 Lachancea thermotolerans KLTH0D14608g hypothetical protein
LALA0_S03e06040g	weakly similar to uniprot|Q6B149 Saccharomyces cerevisiae YPR075C OPY2 Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone
LALA0_S03e06062g	highly similar to uniprot|P33315 Saccharomyces cerevisiae YBR117C (ohnolog of YPR074C) TKL2 Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
LALA0_S03e06084g	similar to uniprot|P40347 Saccharomyces cerevisiae YPR073C LTP1 Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine
LALA0_S03e06106g	similar to uniprot|Q12514 Saccharomyces cerevisiae YPR072W NOT5 Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
LALA0_S03e06128g	similar to uniprot|P53257 Saccharomyces cerevisiae YGR096W TPC1 Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
LALA0_S03e06150g	similar to uniprot|P53256 Saccharomyces cerevisiae YGR095C RRP46 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
LALA0_S03e06172g	highly similar to uniprot|P07806 Saccharomyces cerevisiae YGR094W VAS1 Mitochondrial and cytoplasmic valyl-tRNA synthetase
LALA0_S03e06194g	similar to uniprot|Q06106 Saccharomyces cerevisiae YPR112C MRD1 Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains
LALA0_S03e06216g	similar to uniprot|P53255 Saccharomyces cerevisiae YGR093W Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
LALA0_S03e06238g	highly similar to uniprot|P22204 Saccharomyces cerevisiae YGR092W (ohnolog of YPR111W) DBF2 Ser/Thrkinase involved in transcription and stress response;functions as part of a network of genes in exit frommitosis; localization is cell cycle regulated; activatedby Cdc15p during the exit from mitosis
LALA0_S03e06260g	similar to uniprot|P49704 Saccharomyces cerevisiae YGR091W PRP31 Splicing factor, component of the U4/U6-U5 snRNP complex
LALA0_S03e06282g	highly similar to uniprot|P07703 Saccharomyces cerevisiae YPR110C RPC40 RNA polymerase subunit AC40, common to RNA polymerase I and III
LALA0_S03e06304g	weakly similar to uniprot|Q6B2S3 Saccharomyces cerevisiae YPR109W Predicted membrane protein; dipoid deletion strain has high budding index
LALA0_S03e06326g	similar to uniprot|P53254 Saccharomyces cerevisiae YGR090W UTP22 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
LALA0_S03e06392g	similar to uniprot|P53253 Saccharomyces cerevisiae YGR089W NNF2 Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
LALA0_S03e06436g	similar to uniprot|P32464 Saccharomyces cerevisiae YKL189W HYM1 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
LALA0_S03e06458g	similar to uniprot|Q06696 Saccharomyces cerevisiae YLR417W VPS36 Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
LALA0_S03e06480g	similar to uniprot|P34230 Saccharomyces cerevisiae YKL188C PXA2 Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
LALA0_S03e06502g	similar to uniprot|Q6B322 Saccharomyces cerevisiae YLR414C PUN1 Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
LALA0_S03e06524g	similar to uniprot|Q06689 Saccharomyces cerevisiae YLR413W (ohnolog of YKL187C) Putative protein of unknown function; YLR413W is not an essential gene
LALA0_S03e06546g	similar to uniprot|P34232 Saccharomyces cerevisiae YKL186C MTR2 mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
LALA0_S03e06568g	weakly similar to uniprot|P34233 Saccharomyces cerevisiae YKL185W ASH1 Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
LALA0_S03e06590g	similar to uniprot|P08432 Saccharomyces cerevisiae YKL184W SPE1 Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
LALA0_S03e06612g	similar to uniprot|P34234 Saccharomyces cerevisiae YKL183W LOT5 Protein of unknown function; gene expression increases in cultures shifted to a lower temperature
LALA0_S03e06634g	highly similar to uniprot|P07149 Saccharomyces cerevisiae YKL182W FAS1 Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
LALA0_S03e06656g	similar to uniprot|Q06688 Saccharomyces cerevisiae YLR412W BER1 Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
LALA0_S03e06678g	highly similar to uniprot|P32895 Saccharomyces cerevisiae YKL181W PRS1 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
LALA0_S03e06700g	similar to uniprot|Q06686 Saccharomyces cerevisiae YLR411W CTR3 High-affinity copper transporter of the plasma membrane acts as a trimer gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
LALA0_S03e06722g	similar to uniprot|Q06685 Saccharomyces cerevisiae YLR410W VIP1 Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1
LALA0_S03e06744g	highly similar to uniprot|Q06078 Saccharomyces cerevisiae YLR409C UTP21 Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma
LALA0_S03e06766g	similar to uniprot|Q07468 Saccharomyces cerevisiae YDL077C VAM6 Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
LALA0_S03e06788g	similar to uniprot|Q06071 Saccharomyces cerevisiae YLR408C BLS1 Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
LALA0_S03e06810g	weakly similar to uniprot|Q06070 Saccharomyces cerevisiae YLR407W Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
LALA0_S03e06832g	similar to uniprot|Q07458 Saccharomyces cerevisiae YDL076C RXT3 Subunit of the RPD3L complex; involved in histone deacetylation
LALA0_S03e06854g	highly similar to uniprot|P04649 Saccharomyces cerevisiae YDL075W (ohnolog of YLR406C) RPL31A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality
LALA0_S03e06876g	similar to uniprot|Q06063 Saccharomyces cerevisiae YLR405W DUS4 Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
LALA0_S03e06898g	similar to uniprot|Q07457 Saccharomyces cerevisiae YDL074C BRE1 E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
LALA0_S03e06920g	weakly similar to uniprot|Q07454 Saccharomyces cerevisiae YDL073W Putative protein of unknown function; YDL073W is not an essential gene
LALA0_S03e06942g	similar to uniprot|Q06058 Saccharomyces cerevisiae YLR404W FLD1 Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
LALA0_S03e06964g	weakly similar to uniprot|P32432 Saccharomyces cerevisiae YLR403W SFP1 Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p; can form the [ISP+] prion
LALA0_S03e06986g	similar to uniprot|Q06053 Saccharomyces cerevisiae YLR401C DUS3 Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
LALA0_S03e07008g	similar to uniprot|Q7LGS8 Saccharomyces cerevisiae YDL072C YET3 Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein
LALA0_S03e07030g	similar to uniprot|Q07442 Saccharomyces cerevisiae YDL070W (ohnolog of YLR399C) BDF2 Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p
LALA0_S03e07052g	similar to uniprot|P35207 Saccharomyces cerevisiae YLR398C SKI2 Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
LALA0_S03e07074g	similar to uniprot|C5DFE5 Lachancea thermotolerans KLTH0D14454g hypothetical protein
LALA0_S03e07096g	highly similar to uniprot|P32794 Saccharomyces cerevisiae YLR397C AFG2 ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs
LALA0_S03e07118g	similar to uniprot|P20795 Saccharomyces cerevisiae YLR396C VPS33 ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole
LALA0_S03e07140g	similar to uniprot|P07255 Saccharomyces cerevisiae YDL067C COX9 Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
LALA0_S03e07162g	similar to uniprot|P04039 Saccharomyces cerevisiae YLR395C COX8 Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
LALA0_S03e07184g	highly similar to uniprot|P21954 Saccharomyces cerevisiae YDL066W IDP1 Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
LALA0_S03e07206g	similar to uniprot|C5DFJ1 Lachancea thermotolerans KLTH0D15510g hypothetical protein
LALA0_S03e07228g	similar to uniprot|P18496 Saccharomyces cerevisiae YLR393W ATP10 Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
LALA0_S03e07250g	weakly similar to uniprot|P18634 Saccharomyces cerevisiae YLR392C ART10 Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene
LALA0_S03e07272g	similar to uniprot|O13547 Saccharomyces cerevisiae YLR390W-A CCW14 Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
LALA0_S03e07294g	similar to uniprot|Q07418 Saccharomyces cerevisiae YDL065C PEX19 Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane
LALA0_S03e07316g	similar to uniprot|Q06697 Saccharomyces cerevisiae YLR418C CDC73 Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
LALA0_S03e07338g	highly similar to uniprot|P25296 Saccharomyces cerevisiae YKL190W CNB1 Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
LALA0_S03e07360g	similar to uniprot|P32461 Saccharomyces cerevisiae YKL191W DPH2 Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
LALA0_S03e07382g	highly similar to uniprot|P20051 Saccharomyces cerevisiae YLR420W URA4 Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
LALA0_S03e07404g	some similarities with uniprot|O13563 Saccharomyces cerevisiae YLR421C RPN13 Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability
LALA0_S03e07426g	similar to uniprot|C5DFN1 Lachancea thermotolerans KLTH0D16456g hypothetical protein
LALA0_S03e07448g	similar to uniprot|Q06409 Saccharomyces cerevisiae YLR422W Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein
LALA0_S03e07470g	similar to uniprot|P32463 Saccharomyces cerevisiae YKL192C ACP1 Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
LALA0_S03e07492g	similar to uniprot|P36047 Saccharomyces cerevisiae YKL193C SDS22 Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis
LALA0_S03e07514g	similar to uniprot|P07236 Saccharomyces cerevisiae YKL194C MST1 Mitochondrial threonyl-tRNA synthetase
LALA0_S03e07536g	similar to uniprot|Q06410 Saccharomyces cerevisiae YLR423C ATG17 Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells
LALA0_S03e07558g	weakly similar to uniprot|Q06411 Saccharomyces cerevisiae YLR424W SPP382 Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
LALA0_S03e07580g	some similarities with uniprot|P36046 Saccharomyces cerevisiae YKL195W MIA40 Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins
LALA0_S03e07602g	highly similar to uniprot|P36015 Saccharomyces cerevisiae YKL196C YKT6 Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
LALA0_S03e07646g	similar to uniprot|Q06412 Saccharomyces cerevisiae YLR425W TUS1 Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
LALA0_S03e07668g	similar to uniprot|Q06417 Saccharomyces cerevisiae YLR426W TDA5 Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele
LALA0_S03e07690g	similar to uniprot|Q04969 Saccharomyces cerevisiae YML055W SPC2 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25
LALA0_S03e07712g	similar to uniprot|Q06436 Saccharomyces cerevisiae YLR427W MAG2 Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
LALA0_S03e07734g	similar to uniprot|Q06440 Saccharomyces cerevisiae YLR429W CRN1 Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly
LALA0_S03e07756g	similar to uniprot|Q00416 Saccharomyces cerevisiae YLR430W SEN1 Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis
LALA0_S03e07778g	weakly similar to uniprot|Q06671 Saccharomyces cerevisiae YLR431C ATG23 Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p
LALA0_S03e07800g	highly similar to uniprot|P50095 Saccharomyces cerevisiae YLR432W (ohnolog of YML056C IMD4) IMD3 Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
LALA0_S03e07822g	similar to uniprot|P14747 Saccharomyces cerevisiae YML057W (ohnolog of YLR433C) CMP2 Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
LALA0_S03e07844g	similar to uniprot|Q06672 Saccharomyces cerevisiae YLR435W TSR2 Protein with a potential role in pre-rRNA processing
LALA0_S03e07866g	weakly similar to uniprot|Q06673 Saccharomyces cerevisiae YLR436C ECM30 Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm
LALA0_S03e07888g	weakly similar to uniprot|Q04964 Saccharomyces cerevisiae YML058W (ohnolog of YLR437C) SML1 Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
LALA0_S03e07910g	similar to uniprot|P07991 Saccharomyces cerevisiae YLR438W CAR2 L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
LALA0_S03e07932g	highly similar to uniprot|P00359 Saccharomyces cerevisiae YGR192C (ohnolog of YJR009C) TDH3 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall
LALA0_S03e07976g	similar to uniprot|Q04958 Saccharomyces cerevisiae YML059C NTE1 Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes
LALA0_S03e07998g	similar to uniprot|P57743 Saccharomyces cerevisiae YLR438C-A LSM3 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
LALA0_S03e08020g	similar to uniprot|P36517 Saccharomyces cerevisiae YLR439W MRPL4 Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
LALA0_S03e08042g	similar to uniprot|P53397 Saccharomyces cerevisiae YML060W OGG1 Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance
LALA0_S03e08064g	similar to uniprot|P07271 Saccharomyces cerevisiae YML061C PIF1 DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis
LALA0_S03e08086g	similar to uniprot|Q7LHI0 Saccharomyces cerevisiae YLR440C SEC39 Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
LALA0_S03e08108g	weakly similar to uniprot|P33441 Saccharomyces cerevisiae YML062C MFT1 Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
LALA0_S03e08130g	highly similar to uniprot|P23248 Saccharomyces cerevisiae YML063W (ohnolog of YLR441C) RPS1B Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
LALA0_S03e08152g	similar to uniprot|P38987 Saccharomyces cerevisiae YML064C TEM1 GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
LALA0_S03e08174g	weakly similar to uniprot|P54784 Saccharomyces cerevisiae YML065W (ohnolog of YLR442C) ORC1 Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
LALA0_S03e08196g	weakly similar to uniprot|Q2VQX1 Saccharomyces cerevisiae YLR443W ECM7 Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
LALA0_S03e08218g	weakly similar to uniprot|Q04658 Saccharomyces cerevisiae YML066C SMA2 Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation
LALA0_S03e08240g	similar to uniprot|Q04651 Saccharomyces cerevisiae YML067C ERV41 Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein
LALA0_S03e08262g	weakly similar to uniprot|Q06201 Saccharomyces cerevisiae YLR445W Putative protein of unknown function; transcription is regulated by Ume6p and induced in response to alpha factor
LALA0_S03e08284g	highly similar to uniprot|Q04636 Saccharomyces cerevisiae YML069W POB3 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases
LALA0_S03e08306g	highly similar to uniprot|P54838 Saccharomyces cerevisiae YML070W DAK1 Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
LALA0_S03e08328g	weakly similar to uniprot|P39743 Saccharomyces cerevisiae YDR388W RVS167 Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin
LALA0_S03e08350g	similar to uniprot|C5DFN2 Lachancea thermotolerans KLTH0D16500g hypothetical protein
LALA0_S03e08394g	similar to uniprot|C5DFN2 Lachancea thermotolerans KLTH0D16500g hypothetical protein
LALA0_S03e08416g	hypothetical protein
LALA0_S03e08438g	similar to uniprot|Q6B2U1 Saccharomyces cerevisiae YLR446W Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
LALA0_S03e08460g	some similarities with uniprot|Q12091 Saccharomyces cerevisiae YPL170W DAP1 Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
LALA0_S03e08482g	weakly similar to uniprot|P24814 Saccharomyces cerevisiae YJR090C GRR1 F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
LALA0_S03e08504g	highly similar to uniprot|P32366 Saccharomyces cerevisiae YLR447C VMA6 Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane
LALA0_S03e08526g	weakly similar to uniprot|Q04632 Saccharomyces cerevisiae YML071C COG8 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
LALA0_S03e08548g	similar to uniprot|Q03640 Saccharomyces cerevisiae YML072C TCB3 Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
LALA0_S03e08570g	highly similar to uniprot|Q02326 Saccharomyces cerevisiae YML073C (ohnolog of YLR448W) RPL6A N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
LALA0_S03e08592g	similar to uniprot|P27466 Saccharomyces cerevisiae YFR014C (ohnolog of YOL016C) CMK1 Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II
LALA0_S03e08614g	highly similar to uniprot|P23337 Saccharomyces cerevisiae YFR015C (ohnolog of YLR258W) GSY1 Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
LALA0_S03e08636g	similar to uniprot|C5DE00 Lachancea thermotolerans KLTH0C05148g hypothetical protein
LALA0_S03e08680g	some similarities with uniprot|P43597 Saccharomyces cerevisiae YFR016C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
LALA0_S03e08702g	similar to uniprot|Q06146 Saccharomyces cerevisiae YLR257W Putative protein of unknown function
LALA0_S03e08746g	similar to uniprot|C5DE00 Lachancea thermotolerans KLTH0C05148g hypothetical protein
LALA0_S03e08768g	similar to uniprot|P53109 Saccharomyces cerevisiae YGL160W AIM14 Protein with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S03e08790g	similar to uniprot|P12351 Saccharomyces cerevisiae YLR256W HAP1 Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
LALA0_S03e08812g	similar to uniprot|Q06568 Saccharomyces cerevisiae YLR254C NDL1 Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
LALA0_S03e08834g	similar to uniprot|Q06567 Saccharomyces cerevisiae YLR253W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene
LALA0_S03e08856g	weakly similar to uniprot|P42884 Saccharomyces cerevisiae YNL331C AAD14 Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
LALA0_S03e08878g	similar to uniprot|Q06563 Saccharomyces cerevisiae YLR251W SYM1 Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17
LALA0_S03e08900g	hypothetical protein
LALA0_S03e08922g	some similarities with Lachancea thermotolerans KLTH0H11682g hypothetical protein
LALA0_S03e08944g	weakly similar to uniprot|Q06247 Saccharomyces cerevisiae YLR173W Putative protein of unknown function
LALA0_S03e08966g	highly similar to uniprot|P32469 Saccharomyces cerevisiae YLR172C DPH5 Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
LALA0_S03e08988g	highly similar to uniprot|P35181 Saccharomyces cerevisiae YLR170C APS1 Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
LALA0_S03e09010g	weakly similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene
LALA0_S03e09054g	similar to uniprot|Q06554 Saccharomyces cerevisiae YLR247C IRC20 Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
LALA0_S03e09076g	putative transposase of the Rover hAT-like DNA transposon, degenerate;putative transposase of the Rover hAT-like DNA transposon, degenerate
LALA0_S03e09098g	similar to uniprot|P38622 Saccharomyces cerevisiae YGL158W (ohnolog of YLR248W) RCK1 Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
LALA0_S03e09120g	highly similar to uniprot|P53978 Saccharomyces cerevisiae YNL014W (ohnolog of YLR249W) HEF3 Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
LALA0_S03e09142g	similar to uniprot|P53541 Saccharomyces cerevisiae YNL012W SPO1 Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B
LALA0_S03e09164g	similar to uniprot|P39931 Saccharomyces cerevisiae YLR250W SSP120 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S03e09186g	similar to uniprot|P53980 Saccharomyces cerevisiae YNL011C Putative protein of unknown function; YNL011C is not an essential gene
LALA0_S03e09208g	hypothetical protein
LALA0_S03e09230g	putative transposase of the Rover hAT-like DNA transposon, degenerate;putative transposase of the Rover hAT-like DNA transposon, degenerate
LALA0_S03e09252g	highly similar to uniprot|P53981 Saccharomyces cerevisiae YNL010W Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
LALA0_S03e09274g	highly similar to uniprot|P53982 Saccharomyces cerevisiae YNL009W (ohnolog of YLR174W) IDP3 Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids
LALA0_S03e09318g	hypothetical protein
LALA0_S03e09340g	similar to uniprot|P25604 Saccharomyces cerevisiae YCL008C STP22 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
LALA0_S03e09362g	highly similar to uniprot|P33322 Saccharomyces cerevisiae YLR175W CBF5 Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
LALA0_S03e09384g	highly similar to uniprot|P25294 Saccharomyces cerevisiae YNL007C SIS1 Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins
LALA0_S03e09406g	highly similar to uniprot|P41318 Saccharomyces cerevisiae YNL006W LST8 Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
LALA0_S03e09428g	weakly similar to uniprot|P48743 Saccharomyces cerevisiae YLR176C RFX1 Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
LALA0_S03e09450g	similar to uniprot|P40693 Saccharomyces cerevisiae YNL002C RLP7 Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
LALA0_S03e09472g	highly similar to uniprot|P04173 Saccharomyces cerevisiae YCL018W LEU2 Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
LALA0_S03e09494g	highly similar to uniprot|P25374 Saccharomyces cerevisiae YCL017C NFS1 Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria
LALA0_S03e09516g	similar to uniprot|P38921 Saccharomyces cerevisiae YNL003C PET8 S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth
LALA0_S03e09538g	similar to uniprot|P25559 Saccharomyces cerevisiae YCL016C DCC1 Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
LALA0_S03e09560g	similar to uniprot|P25558 Saccharomyces cerevisiae YCL014W BUD3 Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
LALA0_S03e09582g	similar to uniprot|Q8J0M4 Saccharomyces cerevisiae YCL012C Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene
LALA0_S03e09604g	similar to uniprot|P25555 Saccharomyces cerevisiae YCL011C (ohnolog of YNL004W) GBP2 Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro
LALA0_S03e09626g	similar to uniprot|P25554 Saccharomyces cerevisiae YCL010C SGF29 Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA recruitment to target promoters and H3 acetylation
LALA0_S03e09648g	similar to uniprot|P12687 Saccharomyces cerevisiae YNL005C MRP7 Mitochondrial ribosomal protein of the large subunit
LALA0_S03e09670g	highly similar to uniprot|P25605 Saccharomyces cerevisiae YCL009C ILV6 Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
LALA0_S03e09692g	weakly similar to uniprot|P25587 Saccharomyces cerevisiae YCL005W LDB16 Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
LALA0_S03e09736g	similar to uniprot|P25578 Saccharomyces cerevisiae YCL004W PGS1 Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis
LALA0_S03e09758g	similar to uniprot|P25565 Saccharomyces cerevisiae YCL002C Putative protein of unknown function; YCL002C is not an essential gene
LALA0_S03e09780g	similar to uniprot|P25560 Saccharomyces cerevisiae YCL001W RER1 Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER
LALA0_S03e09802g	similar to uniprot|Q96VH2 Saccharomyces cerevisiae YCL001W-B (ohnolog of YNL001W) Putative protein of unknown function; YCL001W-B gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
LALA0_S03e09846g	highly similar to uniprot|P25342 Saccharomyces cerevisiae YCR002C CDC10 Component of the septin ring that is required for cytokinesis; septins recruit proteins to the mother-bud neck and can act as a barrier to diffusion at the membrane, and they comprise the 10 nm filaments seen with EM; required for the transition from a single to double septin ring
LALA0_S03e09868g	similar to uniprot|P25348 Saccharomyces cerevisiae YCR003W MRPL32 Mitochondrial ribosomal protein of the large subunit
LALA0_S03e09890g	similar to uniprot|C5E3E2 Lachancea thermotolerans KLTH0H12672g hypothetical protein
LALA0_S03e09912g	highly similar to uniprot|P25349 Saccharomyces cerevisiae YCR004C YCP4 Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S03e09934g	highly similar to uniprot|P08679 Saccharomyces cerevisiae YCR005C (ohnolog of YNR001C) CIT2 Citratesynthase, catalyzes the condensation of acetyl coenzyme Aand oxaloacetate to form citrate, peroxisomal isozymeinvolved in glyoxylate cycle; expression is controlled byRtg1p and Rtg2p transcription factors
LALA0_S03e09978g	similar to uniprot|P25333 Saccharomyces cerevisiae YCR008W SAT4 Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
LALA0_S03e10000g	similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein
LALA0_S03e10044g	highly similar to uniprot|P25343 Saccharomyces cerevisiae YCR009C RVS161 Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
LALA0_S03e10066g	highly similar to uniprot|P32910 Saccharomyces cerevisiae YNR003C RPC34 RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
LALA0_S03e10088g	similar to uniprot|P25371 Saccharomyces cerevisiae YCR011C ADP1 Putative ATP-dependent permease of the ABC transporter family of proteins
LALA0_S03e10110g	similar to uniprot|P43599 Saccharomyces cerevisiae YFR018C Putative protein of unknown function
LALA0_S03e10132g	similar to uniprot|P34756 Saccharomyces cerevisiae YFR019W FAB1 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis
LALA0_S03e10176g	similar to uniprot|P27882 Saccharomyces cerevisiae YGR029W ERV1 Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
LALA0_S03e10198g	similar to uniprot|P43601 Saccharomyces cerevisiae YFR021W ATG18 Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
LALA0_S03e10220g	similar to uniprot|P43602 Saccharomyces cerevisiae YFR022W (ohnolog of YOR018W) ROG3 Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins
LALA0_S03e10242g	weakly similar to uniprot|Q07500 Saccharomyces cerevisiae YDL085W (ohnolog of YMR145C) NDE2 Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
LALA0_S03e10264g	similar to uniprot|P38760 Saccharomyces cerevisiae YHR015W (ohnolog of YFR023W) MIP6 Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
LALA0_S03e10286g	similar to uniprot|P32793 Saccharomyces cerevisiae YHR016C (ohnolog of YFR024C-A) YSC84 Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p
LALA0_S03e10330g	weakly similar to uniprot|P32792 Saccharomyces cerevisiae YHR017W YSC83 Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
LALA0_S03e10352g	highly similar to uniprot|P38707 Saccharomyces cerevisiae YHR019C DED81 Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
LALA0_S03e10374g	highly similar to uniprot|P38708 Saccharomyces cerevisiae YHR020W Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene
LALA0_S03e10396g	similar to uniprot|P38635 Saccharomyces cerevisiae YFR025C HIS2 Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
LALA0_S04e00100g	similar to uniprot|P16965 Saccharomyces cerevisiae YGR008C (ohnolog of YLR327C) STF2 Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
LALA0_S04e00122g	similar to uniprot|P33412 Saccharomyces cerevisiae YGR007W ECT1 Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases
LALA0_S04e00144g	similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Putative protein of unknown function, predicted to be palmitoylated
LALA0_S04e00166g	similar to uniprot|P33411 Saccharomyces cerevisiae YGR006W PRP18 Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p
LALA0_S04e00188g	highly similar to uniprot|P41896 Saccharomyces cerevisiae YGR005C TFG2 TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
LALA0_S04e00210g	highly similar to uniprot|P49167 Saccharomyces cerevisiae YLR325C RPL38 Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
LALA0_S04e00232g	similar to uniprot|P53203 Saccharomyces cerevisiae YGR004W (ohnolog of YLR324W) PEX31 Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
LALA0_S04e00254g	similar to uniprot|P53769 Saccharomyces cerevisiae YLR323C CWC24 Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p
LALA0_S04e00276g	similar to uniprot|P53202 Saccharomyces cerevisiae YGR003W CUL3 Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
LALA0_S04e00298g	similar to uniprot|P53201 Saccharomyces cerevisiae YGR002C SWC4 Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex
LALA0_S04e00320g	weakly similar to uniprot|Q06164 Saccharomyces cerevisiae YLR320W MMS22 Protein that acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; required for accurate meiotic chromosome segregation
LALA0_S04e00342g	similar to uniprot|P41697 Saccharomyces cerevisiae YLR319C BUD6 Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
LALA0_S04e00364g	weakly similar to uniprot|Q06163 Saccharomyces cerevisiae YLR318W EST2 Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
LALA0_S04e00386g	similar to uniprot|Q9URQ3 Saccharomyces cerevisiae YLR316C TAD3 Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs
LALA0_S04e00408g	weakly similar to uniprot|Q06162 Saccharomyces cerevisiae YLR315W NKP2 Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p- Nkp1p-Nkp2p-Ame1p-Mtw1p)
LALA0_S04e00430g	similar to uniprot|Q06168 Saccharomyces cerevisiae YLR321C SFH1 Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
LALA0_S04e00452g	highly similar to uniprot|P32471 Saccharomyces cerevisiae YAL003W EFB1 Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
LALA0_S04e00474g	weakly similar to uniprot|P39702 Saccharomyces cerevisiae YAL002W VPS8 Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif
LALA0_S04e00496g	highly similar to uniprot|P53199 Saccharomyces cerevisiae YGL001C ERG26 C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
LALA0_S04e00540g	similar to uniprot|P53200 Saccharomyces cerevisiae YGR001C Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
LALA0_S04e00562g	similar to uniprot|P34111 Saccharomyces cerevisiae YAL001C TFC3 Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
LALA0_S04e00606g	weakly similar to uniprot|P39705 Saccharomyces cerevisiae YAR002W NUP60 Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; involved in nuclear export and cytoplasmic localization of specific mRNAs such as ASH1
LALA0_S04e00628g	similar to uniprot|Q05359 Saccharomyces cerevisiae YAR002C-A (ohnolog of YGL002W) ERP1 Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
LALA0_S04e00650g	similar to uniprot|P39706 Saccharomyces cerevisiae YAR003W SWD1 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
LALA0_S04e00672g	similar to uniprot|P53197 Saccharomyces cerevisiae YGL003C CDH1 Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p
LALA0_S04e00694g	some similarities with uniprot|P39720 Saccharomyces cerevisiae YAL051W (ohnolog of YOR363C) OAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
LALA0_S04e00716g	similar to uniprot|P22336 Saccharomyces cerevisiae YAR007C RFA1 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
LALA0_S04e00738g	similar to uniprot|P53195 Saccharomyces cerevisiae YGL005C COG7 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
LALA0_S04e00760g	similar to uniprot|P38929 Saccharomyces cerevisiae YGL006W PMC1 Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
LALA0_S04e00782g	similar to uniprot|P39707 Saccharomyces cerevisiae YAR008W SEN34 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
LALA0_S04e00848g	similar to uniprot|Q12012 Saccharomyces cerevisiae YOR289W Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S04e00870g	similar to uniprot|Q12404 Saccharomyces cerevisiae YOR288C MPD1 Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
LALA0_S04e00892g	similar to uniprot|P19956 Saccharomyces cerevisiae YMR225C MRPL44 Mitochondrial ribosomal protein of the large subunit
LALA0_S04e00914g	similar to uniprot|Q12481 Saccharomyces cerevisiae YOR287C RRP36 Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
LALA0_S04e00936g	similar to uniprot|Q08742 Saccharomyces cerevisiae YOR286W RDL2 Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S04e00958g	similar to uniprot|Q12305 Saccharomyces cerevisiae YOR285W RDL1 Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane
LALA0_S04e00980g	similar to uniprot|Q12040 Saccharomyces cerevisiae YOR283W Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
LALA0_S04e01002g	similar to uniprot|P32829 Saccharomyces cerevisiae YMR224C MRE11 Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved
LALA0_S04e01024g	highly similar to uniprot|Q12017 Saccharomyces cerevisiae YOR281C PLP2 Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP
LALA0_S04e01046g	similar to uniprot|P50102 Saccharomyces cerevisiae YMR223W UBP8 Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
LALA0_S04e01068g	similar to uniprot|P34218 Saccharomyces cerevisiae YBL052C SAS3 Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal
LALA0_S04e01090g	weakly similar to uniprot|P40059 Saccharomyces cerevisiae YER088C (ohnolog of YBL054W) DOT6 Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation
LALA0_S04e01112g	highly similar to uniprot|C5DCU8 Lachancea thermotolerans KLTH0B05962g hypothetical protein
LALA0_S04e01134g	weakly similar to uniprot|P53550 Saccharomyces cerevisiae YNL118C DCP2 Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
LALA0_S04e01156g	similar to uniprot|P53923 Saccharomyces cerevisiae YNL119W NCS2 Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
LALA0_S04e01178g	similar to uniprot|P38824 Saccharomyces cerevisiae YHR116W COX23 Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
LALA0_S04e01200g	similar to uniprot|P38825 Saccharomyces cerevisiae YHR117W (ohnolog of YNL121C) TOM71 Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins
LALA0_S04e01222g	similar to uniprot|P53921 Saccharomyces cerevisiae YNL122C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene
LALA0_S04e01244g	highly similar to uniprot|P53920 Saccharomyces cerevisiae YNL123W NMA111 Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
LALA0_S04e01266g	similar to uniprot|P38826 Saccharomyces cerevisiae YHR118C ORC6 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
LALA0_S04e01288g	similar to uniprot|P38827 Saccharomyces cerevisiae YHR119W SET1 Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain
LALA0_S04e01310g	similar to uniprot|P25846 Saccharomyces cerevisiae YHR120W MSH1 DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
LALA0_S04e01332g	similar to uniprot|P53919 Saccharomyces cerevisiae YNL124W NAF1 RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
LALA0_S04e01354g	similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
LALA0_S04e01376g	similar to uniprot|P53540 Saccharomyces cerevisiae YNL126W SPC98 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
LALA0_S04e01398g	similar to uniprot|P53917 Saccharomyces cerevisiae YNL127W FAR11 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2
LALA0_S04e01420g	some similarities with uniprot|P38828 Saccharomyces cerevisiae YHR121W LSM12 Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS
LALA0_S04e01442g	similar to uniprot|P53916 Saccharomyces cerevisiae YNL128W TEP1 Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation
LALA0_S04e01464g	similar to uniprot|P53915 Saccharomyces cerevisiae YNL129W NRK1 Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
LALA0_S04e01486g	similar to uniprot|P38829 Saccharomyces cerevisiae YHR122W Protein of unknown function required for establishment of sister chromatid cohesion; synthetically lethal with RFC5, an RF-C subunit that links replication to cohesion establishment; YHR122W is an essential gene
LALA0_S04e01508g	similar to uniprot|P22140 Saccharomyces cerevisiae YHR123W (ohnolog of YNL130C) EPT1 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
LALA0_S04e01530g	similar to uniprot|P49334 Saccharomyces cerevisiae YNL131W TOM22 Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
LALA0_S04e01552g	highly similar to uniprot|P53914 Saccharomyces cerevisiae YNL132W KRE33 Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
LALA0_S04e01574g	weakly similar to uniprot|P38830 Saccharomyces cerevisiae YHR124W NDT80 Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
LALA0_S04e01618g	weakly similar to uniprot|P53913 Saccharomyces cerevisiae YNL133C FYV6 Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
LALA0_S04e01640g	similar to uniprot|P53912 Saccharomyces cerevisiae YNL134C Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
LALA0_S04e01662g	similar to uniprot|P43497 Saccharomyces cerevisiae YKL096W-A CWP2 Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
LALA0_S04e01684g	highly similar to uniprot|P20081 Saccharomyces cerevisiae YNL135C FPR1 Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
LALA0_S04e01706g	weakly similar to uniprot|P53911 Saccharomyces cerevisiae YNL136W EAF7 Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
LALA0_S04e01728g	similar to uniprot|P27929 Saccharomyces cerevisiae YNL137C NAM9 Mitochondrial ribosomal component of the small subunit
LALA0_S04e01750g	similar to uniprot|P17555 Saccharomyces cerevisiae YNL138W SRV2 CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
LALA0_S04e01772g	weakly similar to uniprot|P38833 Saccharomyces cerevisiae YHR127W Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis
LALA0_S04e01794g	similar to uniprot|P0C074 Saccharomyces cerevisiae YNL138W-A YSF3 Component of the SF3b subcomplex of the U2 snRNP, essential protein required for for splicing and for assembly of SF3b
LALA0_S04e01816g	similar to uniprot|P53552 Saccharomyces cerevisiae YNL139C THO2 Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids
LALA0_S04e01838g	similar to uniprot|P53901 Saccharomyces cerevisiae YNL152W INN1 Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function
LALA0_S04e01860g	similar to uniprot|P17890 Saccharomyces cerevisiae YNL151C RPC31 RNA polymerase III subunit C31
LALA0_S04e01882g	similar to uniprot|P53903 Saccharomyces cerevisiae YNL149C PGA2 Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
LALA0_S04e01904g	weakly similar to uniprot|P53904 Saccharomyces cerevisiae YNL148C ALF1 Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
LALA0_S04e01926g	similar to uniprot|P53905 Saccharomyces cerevisiae YNL147W LSM7 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
LALA0_S04e01948g	highly similar to uniprot|P18562 Saccharomyces cerevisiae YHR128W FUR1 Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
LALA0_S04e01970g	similar to uniprot|P38696 Saccharomyces cerevisiae YHR129C ARP1 Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
LALA0_S04e01992g	highly similar to uniprot|C5DCW1 Lachancea thermotolerans KLTH0B06248g hypothetical protein
LALA0_S04e02014g	weakly similar to uniprot|P38835 Saccharomyces cerevisiae YHR131C (ohnolog of YNL144C) Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
LALA0_S04e02036g	weakly similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
LALA0_S04e02058g	weakly similar to uniprot|P53895 Saccharomyces cerevisiae YNL159C ASI2 Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
LALA0_S04e02080g	weakly similar to uniprot|P53896 Saccharomyces cerevisiae YNL158W PGA1 Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes
LALA0_S04e02102g	similar to uniprot|P38836 Saccharomyces cerevisiae YHR132C ECM14 Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly
LALA0_S04e02124g	similar to uniprot|Q9P305 Saccharomyces cerevisiae YHR132W-A (ohnolog of YNL157W) IGO2 Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p
LALA0_S04e02146g	similar to uniprot|P38837 Saccharomyces cerevisiae YHR133C (ohnolog of YNL156C) NSG1 Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins
LALA0_S04e02168g	similar to uniprot|P38838 Saccharomyces cerevisiae YHR134W WSS1 Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response
LALA0_S04e02190g	similar to uniprot|P53899 Saccharomyces cerevisiae YNL155W Putative protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic
LALA0_S04e02212g	similar to uniprot|Q03049 Saccharomyces cerevisiae YDR541C Putative dihydrokaempferol 4-reductase
LALA0_S04e02234g	similar to uniprot|P23291 Saccharomyces cerevisiae YHR135C (ohnolog of YNL154C) YCK1 Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p
LALA0_S04e02256g	similar to uniprot|P53909 Saccharomyces cerevisiae YNL141W AAH1 Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
LALA0_S04e02278g	weakly similar to uniprot|C5DI46 Lachancea thermotolerans KLTH0E09636g hypothetical protein
LALA0_S04e02300g	similar to uniprot|C5DI46 Lachancea thermotolerans KLTH0E09636g hypothetical protein
LALA0_S04e02322g	highly similar to uniprot|P50873 Saccharomyces cerevisiae YDL079C (ohnolog of YMR139W) MRK1 Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
LALA0_S04e02344g	similar to uniprot|Q07471 Saccharomyces cerevisiae YDL080C THI3 Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
LALA0_S04e02366g	weakly similar to uniprot|P41696 Saccharomyces cerevisiae YOR113W AZF1 Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance
LALA0_S04e02388g	similar to uniprot|Q12219 Saccharomyces cerevisiae YOR114W Putative protein of unknown function; null mutant is viable
LALA0_S04e02410g	similar to uniprot|Q99394 Saccharomyces cerevisiae YOR115C TRS33 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
LALA0_S04e02432g	similar to uniprot|P38822 Saccharomyces cerevisiae YHR114W BZZ1 SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
LALA0_S04e02454g	similar to uniprot|P53925 Saccharomyces cerevisiae YNL115C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
LALA0_S04e02476g	similar to uniprot|P38823 Saccharomyces cerevisiae YHR115C (ohnolog of YNL116W) DMA1 Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr.
LALA0_S04e02498g	highly similar to uniprot|P30952 Saccharomyces cerevisiae YNL117W MLS1 Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
LALA0_S04e02520g	similar to uniprot|P50277 Saccharomyces cerevisiae YNR058W BIO3 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
LALA0_S04e02542g	similar to uniprot|P47181 Saccharomyces cerevisiae YJR154W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S04e02564g	similar to uniprot|P38122 Saccharomyces cerevisiae YBR176W ECM31 Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
LALA0_S04e02586g	similar to uniprot|Q02883 Saccharomyces cerevisiae YPL103C FMP30 Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE- specific phospholipase D
LALA0_S04e02608g	similar to uniprot|Q02884 Saccharomyces cerevisiae YPL101W ELP4 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
LALA0_S04e02630g	similar to uniprot|Q02887 Saccharomyces cerevisiae YPL100W ATG21 Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
LALA0_S04e02652g	similar to uniprot|Q02888 Saccharomyces cerevisiae YPL099C AIM43 Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S04e02674g	similar to uniprot|Q02889 Saccharomyces cerevisiae YPL098C MGR2 Protein required for growth of cells lacking the mitochondrial genome
LALA0_S04e02696g	similar to uniprot|P48527 Saccharomyces cerevisiae YPL097W MSY1 Mitochondrial tyrosyl-tRNA synthetase
LALA0_S04e02718g	similar to uniprot|P62651 Saccharomyces cerevisiae YPL096C-A ERI1 Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein
LALA0_S04e02740g	similar to uniprot|Q02890 Saccharomyces cerevisiae YPL096W PNG1 Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p
LALA0_S04e02762g	similar to uniprot|P38295 Saccharomyces cerevisiae YBR177C (ohnolog of YPL095C) EHT1 Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
LALA0_S04e02784g	similar to uniprot|P38297 Saccharomyces cerevisiae YBR179C FZO1 Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
LALA0_S04e02806g	similar to uniprot|P21825 Saccharomyces cerevisiae YPL094C SEC62 Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
LALA0_S04e02828g	highly similar to uniprot|Q02892 Saccharomyces cerevisiae YPL093W NOG1 Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
LALA0_S04e02850g	similar to uniprot|P38125 Saccharomyces cerevisiae YBR180W DTR1 Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
LALA0_S04e02872g	similar to uniprot|Q2VQ77 Saccharomyces cerevisiae YPL092W SSU1 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
LALA0_S04e02894g	highly similar to uniprot|P41921 Saccharomyces cerevisiae YPL091W GLR1 Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia
LALA0_S04e02916g	highly similar to uniprot|P0CX38 Saccharomyces cerevisiae YBR181C (ohnolog of YPL090C) RPS6B Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
LALA0_S04e02938g	weakly similar to uniprot|P38128 Saccharomyces cerevisiae YBR182C (ohnolog of YPL089C) SMP1 Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
LALA0_S04e02960g	similar to uniprot|P38298 Saccharomyces cerevisiae YBR183W (ohnolog of YPL087W) YPC1 Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
LALA0_S04e02982g	similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
LALA0_S04e03004g	highly similar to uniprot|Q02908 Saccharomyces cerevisiae YPL086C ELP3 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
LALA0_S04e03026g	weakly similar to uniprot|P48415 Saccharomyces cerevisiae YPL085W SEC16 COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
LALA0_S04e03048g	similar to uniprot|P38300 Saccharomyces cerevisiae YBR185C MBA1 Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane
LALA0_S04e03070g	similar to uniprot|P48582 Saccharomyces cerevisiae YPL084W BRO1 Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
LALA0_S04e03092g	similar to uniprot|Q02825 Saccharomyces cerevisiae YPL083C SEN54 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
LALA0_S04e03114g	hypothetical protein
LALA0_S04e03136g	similar to uniprot|P38126 Saccharomyces cerevisiae YBR186W PCH2 Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA
LALA0_S04e03158g	similar to uniprot|P38301 Saccharomyces cerevisiae YBR187W GDT1 Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis
LALA0_S04e03180g	weakly similar to uniprot|P38302 Saccharomyces cerevisiae YBR188C NTC20 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
LALA0_S04e03202g	highly similar to uniprot|P32333 Saccharomyces cerevisiae YPL082C MOT1 Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity
LALA0_S04e03224g	highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W (ohnolog of YDL182W) LYS21 Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p
LALA0_S04e03246g	highly similar to uniprot|P05755 Saccharomyces cerevisiae YBR189W (ohnolog of YPL081W) RPS9B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
LALA0_S04e03268g	highly similar to uniprot|Q02753 Saccharomyces cerevisiae YBR191W (ohnolog of YPL079W) RPL21A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein
LALA0_S04e03290g	highly similar to uniprot|P38127 Saccharomyces cerevisiae YBR192W RIM2 Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
LALA0_S04e03312g	similar to uniprot|P38304 Saccharomyces cerevisiae YBR193C MED8 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
LALA0_S04e03334g	highly similar to uniprot|P05626 Saccharomyces cerevisiae YPL078C ATP4 Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated
LALA0_S04e03356g	similar to uniprot|P13712 Saccharomyces cerevisiae YBR195C MSI1 Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46
LALA0_S04e03378g	highly similar to uniprot|P12709 Saccharomyces cerevisiae YBR196C PGI1 Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation
LALA0_S04e03400g	some similarities with uniprot|P38306 Saccharomyces cerevisiae YBR197C (ohnolog of YPL077C) Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene
LALA0_S04e03422g	similar to uniprot|P46961 Saccharomyces cerevisiae YPL076W GPI2 Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein
LALA0_S04e03444g	similar to uniprot|P38129 Saccharomyces cerevisiae YBR198C TAF5 Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
LALA0_S04e03466g	weakly similar to uniprot|P07261 Saccharomyces cerevisiae YPL075W GCR1 Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
LALA0_S04e03488g	similar to uniprot|P40328 Saccharomyces cerevisiae YPL074W YTA6 Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells
LALA0_S04e03510g	some similarities with uniprot|Q02863 Saccharomyces cerevisiae YPL072W UBP16 Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria
LALA0_S04e03532g	similar to uniprot|P29366 Saccharomyces cerevisiae YBR200W BEM1 Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
LALA0_S04e03554g	weakly similar to uniprot|Q02864 Saccharomyces cerevisiae YPL071C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S04e03576g	similar to uniprot|Q02866 Saccharomyces cerevisiae YPL070W MUK1 Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
LALA0_S04e03598g	similar to uniprot|Q12051 Saccharomyces cerevisiae YPL069C BTS1 Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
LALA0_S04e03620g	similar to uniprot|P38307 Saccharomyces cerevisiae YBR201W DER1 Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
LALA0_S04e03642g	weakly similar to uniprot|C5DIG7 Lachancea thermotolerans KLTH0E12386g hypothetical protein
LALA0_S04e03664g	weakly similar to uniprot|Q6Q586 Saccharomyces cerevisiae YPL067C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
LALA0_S04e03686g	highly similar to uniprot|P38132 Saccharomyces cerevisiae YBR202W MCM7 Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex
LALA0_S04e03708g	similar to uniprot|Q12194 Saccharomyces cerevisiae YPL066W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
LALA0_S04e03730g	similar to uniprot|Q02767 Saccharomyces cerevisiae YPL065W VPS28 Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
LALA0_S04e03752g	weakly similar to uniprot|Q02770 Saccharomyces cerevisiae YPL064C CWC27 Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p
LALA0_S04e03774g	similar to uniprot|Q02776 Saccharomyces cerevisiae YPL063W TIM50 Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
LALA0_S04e03796g	weakly similar to uniprot|P38308 Saccharomyces cerevisiae YBR203W COS111 Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S04e03818g	highly similar to uniprot|P54115 Saccharomyces cerevisiae YPL061W ALD6 Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
LALA0_S04e03840g	similar to uniprot|P38139 Saccharomyces cerevisiae YBR204C LDH1 Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
LALA0_S04e03862g	weakly similar to uniprot|P53324 Saccharomyces cerevisiae YGR263C SAY1 Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
LALA0_S04e03884g	similar to uniprot|P38130 Saccharomyces cerevisiae YBR205W KTR3 Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles
LALA0_S04e03906g	similar to uniprot|Q6B1B1 Saccharomyces cerevisiae YPL060W MFM1 Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p
LALA0_S04e03928g	similar to uniprot|P38310 Saccharomyces cerevisiae YBR207W FTH1 Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis
LALA0_S04e03950g	highly similar to uniprot|P32528 Saccharomyces cerevisiae YBR208C DUR1,2 Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
LALA0_S04e03972g	similar to uniprot|Q02784 Saccharomyces cerevisiae YPL059W GRX5 Hydroperoxide and superoxide-radicalresponsive glutathione-dependent oxidoreductase;mitochondrial matrix protein involved in thesynthesis/assembly of iron-sulfur centers; monothiolglutaredoxin subfamily member along with Grx3p and Grx4p
LALA0_S04e03994g	similar to uniprot|P38289 Saccharomyces cerevisiae YBR163W EXO5 Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2
LALA0_S04e04016g	similar to uniprot|P38374 Saccharomyces cerevisiae YBR162W-A YSY6 Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
LALA0_S04e04038g	hypothetical protein
LALA0_S04e04060g	similar to uniprot|P38288 Saccharomyces cerevisiae YBR162C TOS1 Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
LALA0_S04e04082g	similar to uniprot|P38287 Saccharomyces cerevisiae YBR161W (ohnolog of YPL057C) CSH1 Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p
LALA0_S04e04104g	weakly similar to uniprot|C5DCQ7 Lachancea thermotolerans KLTH0B05038g hypothetical protein
LALA0_S04e04126g	similar to uniprot|C5DIE2 Lachancea thermotolerans KLTH0E11814g hypothetical protein
LALA0_S04e04148g	highly similar to uniprot|P00546 Saccharomyces cerevisiae YBR160W CDC28 Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
LALA0_S04e04170g	highly similar to uniprot|P38286 Saccharomyces cerevisiae YBR159W IFA38 Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
LALA0_S04e04192g	some similarities with uniprot|Q6Q5I8 Saccharomyces cerevisiae YPL055C LGE1 Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
LALA0_S04e04214g	similar to uniprot|P38285 Saccharomyces cerevisiae YBR158W AMN1 Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
LALA0_S04e04236g	some similarities with uniprot|Q06701 Saccharomyces cerevisiae YPL054W LEE1 Zinc-finger protein of unknown function
LALA0_S04e04258g	weakly similar to Lachancea thermotolerans KLTH0E11704g hypothetical protein
LALA0_S04e04280g	weakly similar to uniprot|P38283 Saccharomyces cerevisiae YBR156C SLI15 Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
LALA0_S04e04302g	similar to uniprot|P33313 Saccharomyces cerevisiae YBR155W CNS1 TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
LALA0_S04e04324g	similar to uniprot|P27809 Saccharomyces cerevisiae YDR483W (ohnolog of YPL053C) KRE2 Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation
LALA0_S04e04346g	similar to uniprot|C5DIB0 Lachancea thermotolerans KLTH0E11088g hypothetical protein
LALA0_S04e04368g	similar to uniprot|Q03375 Saccharomyces cerevisiae YDR482C CWC21 Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p
LALA0_S04e04390g	highly similar to uniprot|Q02804 Saccharomyces cerevisiae YPL051W ARL3 GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
LALA0_S04e04412g	similar to uniprot|P11491 Saccharomyces cerevisiae YDR481C PHO8 Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN
LALA0_S04e04434g	highly similar to uniprot|P39107 Saccharomyces cerevisiae YPL050C MNN9 Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation
LALA0_S04e04456g	weakly similar to uniprot|Q03373 Saccharomyces cerevisiae YDR480W (ohnolog of YPL049C) DIG2 MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p
LALA0_S04e04478g	similar to uniprot|P29547 Saccharomyces cerevisiae YPL048W CAM1 Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
LALA0_S04e04500g	highly similar to uniprot|P15202 Saccharomyces cerevisiae YDR256C CTA1 Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
LALA0_S04e04522g	similar to uniprot|Q03067 Saccharomyces cerevisiae YPL047W SGF11 Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
LALA0_S04e04544g	similar to uniprot|Q12508 Saccharomyces cerevisiae YDR255C RMD5 Conserved protein that has an E3-like ubiquitin ligase activity necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; also required for sporulation; has a degenerate RING finger domain
LALA0_S04e04566g	similar to uniprot|O13292 Saccharomyces cerevisiae YPL046C ELC1 Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair
LALA0_S04e04588g	similar to uniprot|Q03308 Saccharomyces cerevisiae YPL045W VPS16 Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages
LALA0_S04e04610g	weakly similar to uniprot|P38907 Saccharomyces cerevisiae YDR254W CHL4 Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore subcomplex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p
LALA0_S04e04632g	similar to uniprot|P37838 Saccharomyces cerevisiae YPL043W NOP4 Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
LALA0_S04e04654g	similar to uniprot|P39073 Saccharomyces cerevisiae YPL042C SSN3 Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
LALA0_S04e04676g	similar to uniprot|Q6LE92 Saccharomyces cerevisiae YPL041C Protein of unknown function involved in maintenance of proper telomere length
LALA0_S04e04698g	similar to uniprot|P48526 Saccharomyces cerevisiae YPL040C ISM1 Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
LALA0_S04e04720g	weakly similar to uniprot|Q12041 Saccharomyces cerevisiae YDR253C (ohnolog of YPL038W) MET32 Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p
LALA0_S04e04742g	similar to uniprot|P40314 Saccharomyces cerevisiae YDR252W (ohnolog of YPL037C) BTT1 Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
LALA0_S04e04786g	similar to uniprot|P37304 Saccharomyces cerevisiae YDR251W (ohnolog of YPL032C) PAM1 Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
LALA0_S04e04808g	similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S04e04830g	weakly similar to uniprot|Q03787 Saccharomyces cerevisiae YDR249C Putative protein of unknown function
LALA0_S04e04852g	highly similar to uniprot|P17157 Saccharomyces cerevisiae YPL031C PHO85 Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
LALA0_S04e04874g	similar to uniprot|Q2XN15 Saccharomyces cerevisiae YPL030W TRM44 tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
LALA0_S04e04896g	similar to uniprot|P32580 Saccharomyces cerevisiae YPL029W SUV3 ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
LALA0_S04e04918g	highly similar to uniprot|P41338 Saccharomyces cerevisiae YPL028W ERG10 Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
LALA0_S04e04940g	similar to uniprot|Q03786 Saccharomyces cerevisiae YDR248C Putative protein of unknown function; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1
LALA0_S04e04962g	similar to uniprot|Q03785 Saccharomyces cerevisiae YDR247W (ohnolog of YPL026C) VHS1 Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
LALA0_S04e04984g	highly similar to uniprot|C5DM90 Lachancea thermotolerans KLTH0G06908g hypothetical protein
LALA0_S04e05006g	similar to uniprot|Q03784 Saccharomyces cerevisiae YDR246W TRS23 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4
LALA0_S04e05028g	similar to uniprot|Q02685 Saccharomyces cerevisiae YPL024W RMI1 Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing and ssDNA binding activities of Top3p; involved in response to DNA damage; null mutants display increased rates of recombination and delayed S phase
LALA0_S04e05050g	similar to uniprot|P46151 Saccharomyces cerevisiae YPL023C MET12 Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR
LALA0_S04e05072g	weakly similar to uniprot|P38290 Saccharomyces cerevisiae YBR165W UBS1 Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
LALA0_S04e05094g	highly similar to uniprot|P20049 Saccharomyces cerevisiae YBR166C TYR1 Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels
LALA0_S04e05116g	similar to uniprot|P32459 Saccharomyces cerevisiae YIR032C DAL3 Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
LALA0_S04e05138g	similar to uniprot|Q02872 Saccharomyces cerevisiae YPL108W Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
LALA0_S04e05160g	similar to uniprot|P38291 Saccharomyces cerevisiae YBR167C POP7 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
LALA0_S04e05182g	weakly similar to uniprot|P38292 Saccharomyces cerevisiae YBR168W PEX32 Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
LALA0_S04e05204g	similar to uniprot|Q02873 Saccharomyces cerevisiae YPL107W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene
LALA0_S04e05226g	highly similar to uniprot|P32590 Saccharomyces cerevisiae YBR169C (ohnolog of YPL106C) SSE2 Member of theheat shock protein 70 (HSP70) family; may be involved inprotein folding; localized to the cytoplasm; highlyhomologous to the heat shock protein Sse1p
LALA0_S04e05248g	similar to uniprot|P33755 Saccharomyces cerevisiae YBR170C NPL4 Ubiquitin-binding protein involved in protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD)
LALA0_S04e05270g	weakly similar to uniprot|P37898 Saccharomyces cerevisiae YHR047C (ohnolog of YKL157W) AAP1 Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
LALA0_S04e05292g	similar to uniprot|P33754 Saccharomyces cerevisiae YBR171W SEC66 Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
LALA0_S04e05314g	weakly similar to uniprot|P32909 Saccharomyces cerevisiae YBR172C (ohnolog of YPL105C) SMY2 Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2
LALA0_S04e05336g	similar to uniprot|P38293 Saccharomyces cerevisiae YBR173C UMP1 Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
LALA0_S04e05358g	similar to uniprot|P38123 Saccharomyces cerevisiae YBR175W SWD3 Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
LALA0_S04e05380g	similar to uniprot|P15179 Saccharomyces cerevisiae YPL104W MSD1 Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene
LALA0_S04e05402g	similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
LALA0_S04e05424g	weakly similar to uniprot|P07248 Saccharomyces cerevisiae YDR216W ADR1 Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
LALA0_S04e05446g	weakly similar to uniprot|P14737 Saccharomyces cerevisiae YDR217C RAD9 DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate
LALA0_S04e05468g	weakly similar to uniprot|Q05955 Saccharomyces cerevisiae YLR227C ADY4 Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
LALA0_S04e05490g	similar to uniprot|Q05949 Saccharomyces cerevisiae YLR226W BUR2 Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
LALA0_S04e05512g	weakly similar to uniprot|Q04922 Saccharomyces cerevisiae YDR219C MFB1 Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
LALA0_S04e05534g	similar to uniprot|Q04924 Saccharomyces cerevisiae YDR221W GTB1 Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER
LALA0_S04e05556g	similar to uniprot|Q04930 Saccharomyces cerevisiae YDR223W (ohnolog of YLR223C) CRF1 Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain
LALA0_S04e05578g	highly similar to uniprot|Q05946 Saccharomyces cerevisiae YLR222C UTP13 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
LALA0_S04e05600g	similar to uniprot|Q05942 Saccharomyces cerevisiae YLR221C RSA3 Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
LALA0_S04e05622g	similar to uniprot|P47818 Saccharomyces cerevisiae YLR220W CCC1 Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation
LALA0_S04e05644g	highly similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
LALA0_S04e05666g	highly similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
LALA0_S04e05688g	weakly similar to uniprot|Q7LIF4 Saccharomyces cerevisiae YLR219W MSC3 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate
LALA0_S04e05754g	highly similar to uniprot|P07170 Saccharomyces cerevisiae YDR226W ADK1 Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence
LALA0_S04e05776g	weakly similar to uniprot|P11978 Saccharomyces cerevisiae YDR227W SIR4 Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan
LALA0_S04e05798g	similar to uniprot|P39081 Saccharomyces cerevisiae YDR228C PCF11 mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping
LALA0_S04e05820g	highly similar to uniprot|P38988 Saccharomyces cerevisiae YDL198C GGC1 Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
LALA0_S04e05842g	weakly similar to uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
LALA0_S04e05864g	weakly similar to uniprot|Q12407 Saccharomyces cerevisiae YDL199C Putative transporter, member of the sugar porter family
LALA0_S04e05886g	highly similar to uniprot|Q12009 Saccharomyces cerevisiae YDL201W TRM8 Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
LALA0_S04e05908g	similar to uniprot|P36521 Saccharomyces cerevisiae YDL202W MRPL11 Mitochondrial ribosomal protein of the large subunit
LALA0_S04e05930g	similar to uniprot|Q04934 Saccharomyces cerevisiae YDR229W IVY1 Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
LALA0_S04e05952g	similar to uniprot|Q04935 Saccharomyces cerevisiae YDR231C COX20 Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
LALA0_S04e05974g	similar to uniprot|Q07622 Saccharomyces cerevisiae YDL203C ACK1 Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
LALA0_S04e05996g	highly similar to uniprot|P09950 Saccharomyces cerevisiae YDR232W HEM1 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
LALA0_S04e06018g	similar to uniprot|Q04947 Saccharomyces cerevisiae YDR233C (ohnolog of YDL204W) RTN1 ER membrane protein that interacts with Sey1p to maintain ER morphology; interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p; null mutant has an altered ER morphology; member of the RTNLA (reticulon-like A) subfamily
LALA0_S04e06040g	highly similar to uniprot|P49367 Saccharomyces cerevisiae YDR234W LYS4 Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
LALA0_S04e06062g	similar to uniprot|P28789 Saccharomyces cerevisiae YDL205C HEM3 Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme
LALA0_S04e06084g	similar to uniprot|Q03776 Saccharomyces cerevisiae YDR235W PRP42 U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
LALA0_S04e06106g	weakly similar to uniprot|Q12424 Saccharomyces cerevisiae YDL206W Putative protein of unknown function; YDL206W is not an essential protein
LALA0_S04e06128g	similar to uniprot|Q03778 Saccharomyces cerevisiae YDR236C FMN1 Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane
LALA0_S04e06150g	similar to uniprot|Q12315 Saccharomyces cerevisiae YDL207W GLE1 Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the ATPase activities of Dbp1p and Dbp5p at the nuclear pore complex during mRNA export
LALA0_S04e06172g	highly similar to uniprot|P36519 Saccharomyces cerevisiae YDR237W MRPL7 Mitochondrial ribosomal protein of the large subunit
LALA0_S04e06194g	highly similar to uniprot|P41810 Saccharomyces cerevisiae YDR238C SEC26 Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
LALA0_S04e06216g	weakly similar to uniprot|Q03780 Saccharomyces cerevisiae YDR239C Protein of unknown function that may interact with ribosomes, based on co-purification experiments
LALA0_S04e06238g	weakly similar to uniprot|Q03782 Saccharomyces cerevisiae YDR240C SNU56 Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
LALA0_S04e06260g	highly similar to uniprot|P32495 Saccharomyces cerevisiae YDL208W NHP2 Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
LALA0_S04e06304g	similar to uniprot|P38778 Saccharomyces cerevisiae YHR050W SMF2 Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
LALA0_S04e06326g	similar to uniprot|P36054 Saccharomyces cerevisiae YKL159C RCN1 Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region
LALA0_S04e06348g	highly similar to uniprot|P00427 Saccharomyces cerevisiae YHR051W COX6 Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels
LALA0_S04e06370g	similar to uniprot|P36053 Saccharomyces cerevisiae YKL160W ELF1 Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression
LALA0_S04e06392g	similar to uniprot|P38779 Saccharomyces cerevisiae YHR052W CIC1 Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
LALA0_S04e06414g	similar to uniprot|C5DMA1 Lachancea thermotolerans KLTH0G07150g hypothetical protein
LALA0_S04e06436g	similar to uniprot|P38767 Saccharomyces cerevisiae YHR032W ERC1 Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine
LALA0_S04e06458g	similar to uniprot|P38766 Saccharomyces cerevisiae YHR031C RRM3 DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
LALA0_S04e06480g	highly similar to uniprot|Q00772 Saccharomyces cerevisiae YHR030C (ohnolog of YKL161C) SLT2 Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
LALA0_S04e06502g	similar to uniprot|P18962 Saccharomyces cerevisiae YHR028C DAP2 Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
LALA0_S04e06524g	highly similar to uniprot|P38764 Saccharomyces cerevisiae YHR027C RPN1 Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions
LALA0_S04e06546g	highly similar to uniprot|P23968 Saccharomyces cerevisiae YHR026W VMA16 Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
LALA0_S04e06568g	similar to uniprot|Q06494 Saccharomyces cerevisiae YPR127W Protein of unknown function, differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S04e06590g	highly similar to uniprot|P17423 Saccharomyces cerevisiae YHR025W THR1 Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
LALA0_S04e06612g	highly similar to uniprot|P11914 Saccharomyces cerevisiae YHR024C MAS2 Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
LALA0_S04e06634g	similar to uniprot|P08964 Saccharomyces cerevisiae YHR023W MYO1 Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
LALA0_S04e06656g	similar to Lachancea thermotolerans KLTH0G07172g hypothetical protein
LALA0_S04e06678g	similar to uniprot|C5DMF8 Lachancea thermotolerans KLTH0G08536g hypothetical protein
LALA0_S04e06700g	highly similar to uniprot|P38711 Saccharomyces cerevisiae YHR021C (ohnolog of YKL156W) RPS27B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
LALA0_S04e06722g	similar to uniprot|P36056 Saccharomyces cerevisiae YKL155C RSM22 Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
LALA0_S04e06744g	similar to uniprot|P36057 Saccharomyces cerevisiae YKL154W SRP102 Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
LALA0_S04e06766g	similar to uniprot|Q2V2P5 Saccharomyces cerevisiae YIL102C-A Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species
LALA0_S04e06810g	similar to uniprot|P47054 Saccharomyces cerevisiae YJL039C NUP192 Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205
LALA0_S04e06832g	weakly similar to uniprot|P14907 Saccharomyces cerevisiae YJL041W NSP1 Essential component of the nuclear pore complex, which mediates nuclear import and export, found in both the Nup82 and Nic96 complexes
LALA0_S04e06854g	similar to uniprot|P43638 Saccharomyces cerevisiae YJL042W MHP1 Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
LALA0_S04e06876g	similar to uniprot|P32806 Saccharomyces cerevisiae YJL044C GYP6 GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport
LALA0_S04e06898g	highly similar to uniprot|P00950 Saccharomyces cerevisiae YKL152C GPM1 Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
LALA0_S04e06920g	similar to uniprot|P36059 Saccharomyces cerevisiae YKL151C Putative protein of unknown function; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S04e06942g	similar to uniprot|P36060 Saccharomyces cerevisiae YKL150W MCR1 Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
LALA0_S04e06964g	similar to uniprot|P24309 Saccharomyces cerevisiae YKL149C DBR1 RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
LALA0_S04e06986g	highly similar to uniprot|P47052 Saccharomyces cerevisiae YJL045W (ohnolog of YKL148C) Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
LALA0_S04e07008g	weakly similar to uniprot|P36034 Saccharomyces cerevisiae YKL219W COS9 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
LALA0_S04e07030g	similar to uniprot|P36062 Saccharomyces cerevisiae YKL146W AVT3 Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
LALA0_S04e07052g	highly similar to uniprot|P33299 Saccharomyces cerevisiae YKL145W RPT1 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance
LALA0_S04e07074g	highly similar to uniprot|P35718 Saccharomyces cerevisiae YKL144C RPC25 RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
LALA0_S04e07096g	similar to uniprot|P34078 Saccharomyces cerevisiae YKL143W LTV1 Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
LALA0_S04e07118g	similar to uniprot|P35719 Saccharomyces cerevisiae YKL142W MRP8 Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; originally thought to be a mitochondrial ribosomal protein based on sequence analysis
LALA0_S04e07140g	similar to uniprot|P47077 Saccharomyces cerevisiae YJL010C NOP9 Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
LALA0_S04e07162g	highly similar to uniprot|P47079 Saccharomyces cerevisiae YJL008C CCT8 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
LALA0_S04e07206g	similar to uniprot|P47061 Saccharomyces cerevisiae YJL029C VPS53 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
LALA0_S04e07228g	similar to uniprot|P40958 Saccharomyces cerevisiae YJL030W MAD2 Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I
LALA0_S04e07250g	similar to uniprot|Q00618 Saccharomyces cerevisiae YJL031C BET4 Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
LALA0_S04e07272g	similar to uniprot|P46962 Saccharomyces cerevisiae YJL006C CTK2 Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity
LALA0_S04e07294g	highly similar to uniprot|P20448 Saccharomyces cerevisiae YJL033W HCA4 Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
LALA0_S04e07316g	similar to uniprot|Q07930 Saccharomyces cerevisiae YLR016C PML1 Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
LALA0_S04e07338g	highly similar to uniprot|P16474 Saccharomyces cerevisiae YJL034W KAR2 ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
LALA0_S04e07360g	similar to uniprot|P47058 Saccharomyces cerevisiae YJL035C TAD2 Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
LALA0_S04e07382g	similar to uniprot|P47057 Saccharomyces cerevisiae YJL036W SNX4 Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p
LALA0_S04e07404g	similar to uniprot|P43132 Saccharomyces cerevisiae YLR015W BRE2 Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
LALA0_S04e07426g	similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p
LALA0_S04e07470g	similar to uniprot|Q12289 Saccharomyces cerevisiae YOR100C CRC1 Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
LALA0_S04e07492g	similar to uniprot|P27810 Saccharomyces cerevisiae YOR099W KTR1 Alpha-1,2-mannosyltransferase involved in O-and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
LALA0_S04e07514g	weakly similar to uniprot|P20676 Saccharomyces cerevisiae YOR098C NUP1 Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate
LALA0_S04e07536g	weakly similar to uniprot|P53059 Saccharomyces cerevisiae YGL257C MNT2 Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
LALA0_S04e07558g	weakly similar to uniprot|Q12274 Saccharomyces cerevisiae YOR097C Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene
LALA0_S04e07580g	highly similar to uniprot|P26786 Saccharomyces cerevisiae YOR096W (ohnolog of YNL096C) RPS7A Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
LALA0_S04e07602g	similar to uniprot|Q12189 Saccharomyces cerevisiae YOR095C RKI1 Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
LALA0_S04e07624g	highly similar to uniprot|P40994 Saccharomyces cerevisiae YOR094W ARF3 Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
LALA0_S04e07646g	similar to uniprot|Q12275 Saccharomyces cerevisiae YOR093C Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
LALA0_S04e07668g	similar to uniprot|Q99252 Saccharomyces cerevisiae YOR092W (ohnolog of YNL095C) ECM3 Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
LALA0_S04e07690g	similar to uniprot|P53933 Saccharomyces cerevisiae YNL094W APP1 Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
LALA0_S04e07712g	highly similar to uniprot|Q12000 Saccharomyces cerevisiae YOR091W TMA46 Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
LALA0_S04e07734g	similar to uniprot|Q12511 Saccharomyces cerevisiae YOR090C PTC5 Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
LALA0_S04e07756g	highly similar to uniprot|P36017 Saccharomyces cerevisiae YOR089C (ohnolog of YNL093W) VPS21 Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog
LALA0_S04e07778g	similar to uniprot|Q12324 Saccharomyces cerevisiae YOR087W YVC1 Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
LALA0_S04e07800g	weakly similar to uniprot|P53935 Saccharomyces cerevisiae YNL091W NST1 Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
LALA0_S04e07822g	highly similar to uniprot|P06781 Saccharomyces cerevisiae YNL090W RHO2 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
LALA0_S04e07866g	similar to uniprot|P06786 Saccharomyces cerevisiae YNL088W TOP2 Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis
LALA0_S04e07888g	similar to uniprot|Q12466 Saccharomyces cerevisiae YOR086C (ohnolog of YNL087W) TCB1 Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
LALA0_S04e07910g	similar to uniprot|P48232 Saccharomyces cerevisiae YNL086W SNN1 Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
LALA0_S04e07932g	similar to uniprot|P48439 Saccharomyces cerevisiae YOR085W OST3 Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
LALA0_S04e07954g	similar to uniprot|P40850 Saccharomyces cerevisiae YNL085W MKT1 Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more
LALA0_S04e07998g	highly similar to uniprot|P39076 Saccharomyces cerevisiae YIL142W CCT2 Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
LALA0_S04e08020g	similar to uniprot|P39013 Saccharomyces cerevisiae YNL084C END3 EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
LALA0_S04e08042g	similar to uniprot|P38928 Saccharomyces cerevisiae YIL140W AXL2 Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
LALA0_S04e08064g	highly similar to uniprot|C5DMF8 Lachancea thermotolerans KLTH0G08536g hypothetical protein
LALA0_S04e08108g	similar to uniprot|P48233 Saccharomyces cerevisiae YNL083W SAL1 ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains
LALA0_S04e08130g	similar to uniprot|P38927 Saccharomyces cerevisiae YIL139C REV7 Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
LALA0_S04e08152g	similar to uniprot|P14242 Saccharomyces cerevisiae YNL082W PMS1 ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
LALA0_S04e08174g	highly similar to uniprot|P53937 Saccharomyces cerevisiae YNL081C SWS2 Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
LALA0_S04e08196g	similar to uniprot|P53938 Saccharomyces cerevisiae YNL080C EOS1 Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene
LALA0_S04e08218g	highly similar to uniprot|P40414 Saccharomyces cerevisiae YIL138C (ohnolog of YNL079C) TPM2 Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p
LALA0_S04e08240g	hypothetical protein
LALA0_S04e08262g	similar to uniprot|P53940 Saccharomyces cerevisiae YNL077W APJ1 Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S04e08284g	similar to uniprot|P40462 Saccharomyces cerevisiae YIL137C TMA108 Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease
LALA0_S04e08306g	weakly similar to uniprot|P53939 Saccharomyces cerevisiae YNL078W NIS1 Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
LALA0_S04e08328g	some similarities with uniprot|P16547 Saccharomyces cerevisiae YIL136W OM45 Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
LALA0_S04e08350g	weakly similar to uniprot|P34072 Saccharomyces cerevisiae YNL076W MKS1 Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
LALA0_S04e08372g	highly similar to uniprot|P53941 Saccharomyces cerevisiae YNL075W IMP4 Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
LALA0_S04e08394g	weakly similar to uniprot|P40463 Saccharomyces cerevisiae YIL135C (ohnolog of YNL074C) VHS2 Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
LALA0_S04e08438g	similar to uniprot|P32048 Saccharomyces cerevisiae YNL073W MSK1 Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)
LALA0_S04e08460g	similar to uniprot|P53942 Saccharomyces cerevisiae YNL072W RNH201 Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome
LALA0_S04e08482g	highly similar to uniprot|P12695 Saccharomyces cerevisiae YNL071W LAT1 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
LALA0_S04e08504g	highly similar to uniprot|P53507 Saccharomyces cerevisiae YNL070W TOM7 Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
LALA0_S04e08526g	similar to uniprot|P40464 Saccharomyces cerevisiae YIL134W FLX1 Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane
LALA0_S04e08548g	highly similar to uniprot|P26784 Saccharomyces cerevisiae YIL133C (ohnolog of YNL069C) RPL16A N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
LALA0_S04e08570g	similar to uniprot|P40465 Saccharomyces cerevisiae YIL132C CSM2 Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, required for accurate chromosome segregation during meiosis
LALA0_S04e08592g	similar to uniprot|P40466 Saccharomyces cerevisiae YIL131C (ohnolog of YNL068C) FKH1 Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching
LALA0_S04e08614g	similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
LALA0_S04e08636g	similar to uniprot|P40468 Saccharomyces cerevisiae YIL129C TAO3 Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
LALA0_S04e08658g	similar to uniprot|P40469 Saccharomyces cerevisiae YIL128W MET18 DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance
LALA0_S04e08680g	similar to uniprot|P40470 Saccharomyces cerevisiae YIL127C RRT14 Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
LALA0_S04e08702g	similar to uniprot|P32597 Saccharomyces cerevisiae YIL126W STH1 ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
LALA0_S04e08724g	highly similar to uniprot|P51401 Saccharomyces cerevisiae YNL067W RPL9B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins
LALA0_S04e08746g	similar to uniprot|C5DDJ5 Lachancea thermotolerans KLTH0C01496g hypothetical protein
LALA0_S04e08768g	highly similar to uniprot|P20967 Saccharomyces cerevisiae YIL125W KGD1 Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
LALA0_S04e08790g	similar to uniprot|P40472 Saccharomyces cerevisiae YIL123W (ohnolog of YNL066W) SIM1 Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
LALA0_S04e08812g	similar to uniprot|P40474 Saccharomyces cerevisiae YIL121W QDR2 Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake
LALA0_S04e08834g	similar to uniprot|P40475 Saccharomyces cerevisiae YIL120W (ohnolog of YNL065W) QDR1 Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban
LALA0_S04e08856g	highly similar to uniprot|P25491 Saccharomyces cerevisiae YNL064C YDJ1 Type I HSP40 co-chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
LALA0_S04e08878g	similar to uniprot|P53944 Saccharomyces cerevisiae YNL063W MTQ1 S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene
LALA0_S04e08900g	similar to uniprot|P41814 Saccharomyces cerevisiae YNL062C GCD10 Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
LALA0_S04e08922g	highly similar to uniprot|P40991 Saccharomyces cerevisiae YNL061W NOP2 Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
LALA0_S04e08944g	highly similar to uniprot|P53946 Saccharomyces cerevisiae YNL059C ARP5 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
LALA0_S04e08966g	similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
LALA0_S04e08988g	highly similar to uniprot|Q00245 Saccharomyces cerevisiae YIL118W RHO3 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
LALA0_S04e09010g	weakly similar to uniprot|P40476 Saccharomyces cerevisiae YIL117C (ohnolog of YNL058C) PRM5 Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
LALA0_S04e09032g	similar to uniprot|P53949 Saccharomyces cerevisiae YNL056W OCA2 Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
LALA0_S04e09054g	similar to uniprot|P07172 Saccharomyces cerevisiae YIL116W HIS5 Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
LALA0_S04e09076g	weakly similar to uniprot|P40477 Saccharomyces cerevisiae YIL115C NUP159 Nucleoporin, subunit of the Nup82 subcomplex of the nuclear pore; part of the nuclear pore that is found exclusively on the cytoplasmic side; required for mRNA export; regulates ADP release from the ATP-dependent RNA helicase Dbp5p
LALA0_S04e09098g	highly similar to uniprot|P40478 Saccharomyces cerevisiae YIL114C (ohnolog of YNL055C) POR2 Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability
LALA0_S04e09142g	weakly similar to uniprot|P38850 Saccharomyces cerevisiae YHR154W RTT107 Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
LALA0_S04e09164g	similar to uniprot|P50087 Saccharomyces cerevisiae YGR235C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S04e09186g	some similarities with uniprot|P50088 Saccharomyces cerevisiae YGR236C SPG1 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S04e09208g	similar to uniprot|P50089 Saccharomyces cerevisiae YGR237C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S04e09230g	weakly similar to uniprot|C5DDJ3 Lachancea thermotolerans KLTH0C01452g TDA11 topoisomerase I damage affected protein 11
LALA0_S04e09252g	similar to uniprot|P38853 Saccharomyces cerevisiae YHR158C (ohnolog of YGR238C) KEL1 Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
LALA0_S04e09274g	similar to uniprot|C5DDH4 Lachancea thermotolerans KLTH0C01012g hypothetical protein
LALA0_S04e09296g	weakly similar to uniprot|P38855 Saccharomyces cerevisiae YHR160C (ohnolog of YGR239C) PEX18 Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p
LALA0_S04e09318g	weakly similar to uniprot|Q06150 Saccharomyces cerevisiae YLR267W BOP2 Protein of unknown function
LALA0_S04e09340g	highly similar to uniprot|P31412 Saccharomyces cerevisiae YKL080W VMA5 Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
LALA0_S04e09362g	similar to uniprot|P29547 Saccharomyces cerevisiae YPL048W CAM1 Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
LALA0_S04e09384g	similar to uniprot|P36080 Saccharomyces cerevisiae YKL082C RRP14 Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF- 6 family
LALA0_S04e09406g	similar to uniprot|Q04748 Saccharomyces cerevisiae YMR066W SOV1 Mitochondrial protein of unknown function
LALA0_S04e09428g	similar to uniprot|P54730 Saccharomyces cerevisiae YMR067C UBX4 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
LALA0_S04e09450g	weakly similar to uniprot|P53264 Saccharomyces cerevisiae YGR110W CLD1 Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
LALA0_S04e09472g	similar to uniprot|Q04749 Saccharomyces cerevisiae YMR068W AVO2 Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
LALA0_S04e09494g	similar to uniprot|P36078 Saccharomyces cerevisiae YKL084W HOT13 Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc
LALA0_S04e09516g	highly similar to uniprot|P17505 Saccharomyces cerevisiae YKL085W MDH1 Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
LALA0_S04e09538g	similar to uniprot|P38230 Saccharomyces cerevisiae YBR046C ZTA1 NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin
LALA0_S04e09560g	weakly similar to uniprot|P54005 Saccharomyces cerevisiae YMR316W DIA1 Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S04e09582g	weakly similar to uniprot|P54005 Saccharomyces cerevisiae YMR316W DIA1 Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S04e09604g	similar to uniprot|P36077 Saccharomyces cerevisiae YKL086W SRX1 Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes
LALA0_S04e09626g	similar to uniprot|P08539 Saccharomyces cerevisiae YHR005C GPA1 GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome
LALA0_S04e09648g	similar to uniprot|Q00873 Saccharomyces cerevisiae YKL087C CYT2 Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
LALA0_S04e09670g	highly similar to uniprot|P87108 Saccharomyces cerevisiae YHR005C-A TIM10 Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
LALA0_S04e09692g	weakly similar to uniprot|P36076 Saccharomyces cerevisiae YKL088W CAB3 Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC
LALA0_S04e09714g	weakly similar to Lachancea thermotolerans KLTH0C00550g hypothetical protein
LALA0_S04e09736g	similar to uniprot|P07266 Saccharomyces cerevisiae YIR021W (ohnolog of YKL011C) MRS1 Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
LALA0_S04e09758g	similar to uniprot|Q04304 Saccharomyces cerevisiae YMR090W Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability
LALA0_S04e09780g	highly similar to uniprot|P15367 Saccharomyces cerevisiae YIR022W SEC11 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum
LALA0_S04e09802g	similar to uniprot|P33203 Saccharomyces cerevisiae YKL012W PRP40 U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
LALA0_S04e09824g	highly similar to uniprot|P33204 Saccharomyces cerevisiae YKL013C ARC19 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
LALA0_S04e09846g	similar to uniprot|P21657 Saccharomyces cerevisiae YIR023W DAL81 Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
LALA0_S04e09868g	weakly similar to uniprot|P40576 Saccharomyces cerevisiae YIR024C Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect
LALA0_S04e09890g	similar to uniprot|P34241 Saccharomyces cerevisiae YKL014C URB1 Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
LALA0_S04e09912g	similar to uniprot|P25502 Saccharomyces cerevisiae YKL015W PUT3 Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain
LALA0_S04e09956g	highly similar to uniprot|P30902 Saccharomyces cerevisiae YKL016C ATP7 Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
LALA0_S04e09978g	similar to uniprot|P34243 Saccharomyces cerevisiae YKL017C HCS1 Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
LALA0_S04e10000g	highly similar to uniprot|P36104 Saccharomyces cerevisiae YKL018W SWD2 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
LALA0_S04e10022g	weakly similar to uniprot|Q3E7A7 Saccharomyces cerevisiae YKL018C-A Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S04e10044g	weakly similar to uniprot|P40577 Saccharomyces cerevisiae YIR025W MND2 Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase
LALA0_S04e10066g	similar to uniprot|Q02256 Saccharomyces cerevisiae YIR026C YVH1 Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
LALA0_S04e10088g	similar to uniprot|P29703 Saccharomyces cerevisiae YKL019W RAM2 Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
LALA0_S04e10110g	similar to uniprot|P40578 Saccharomyces cerevisiae YIR033W (ohnolog of YKL020C) MGA2 ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
LALA0_S04e10132g	similar to uniprot|P20484 Saccharomyces cerevisiae YKL021C MAK11 Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
LALA0_S04e10154g	highly similar to uniprot|P38998 Saccharomyces cerevisiae YIR034C LYS1 Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity
LALA0_S04e10176g	similar to uniprot|P09798 Saccharomyces cerevisiae YKL022C CDC16 Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
LALA0_S04e10198g	weakly similar to uniprot|C5DML8 Lachancea thermotolerans KLTH0G09966g hypothetical protein
LALA0_S04e10220g	some similarities with uniprot|P15700 Saccharomyces cerevisiae YKL024C URA6 Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
LALA0_S04e10242g	similar to uniprot|P40579 Saccharomyces cerevisiae YIR035C Putative cytoplasmic protein of unknown function
LALA0_S04e10264g	similar to uniprot|P36102 Saccharomyces cerevisiae YKL025C PAN3 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
LALA0_S04e10286g	highly similar to uniprot|P23585 Saccharomyces cerevisiae YMR011W HXT2 High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
LALA0_S04e10308g	weakly similar to uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
LALA0_S05e00100g	highly similar to Lachancea thermotolerans KLTH0F15818g hypothetical protein
LALA0_S05e00144g	similar to uniprot|P43605 Saccharomyces cerevisiae YFR027W ECO1 Acetyltransferase required for establishment of sister chromatid cohesion; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome
LALA0_S05e00166g	similar to uniprot|Q00684 Saccharomyces cerevisiae YFR028C CDC14 Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
LALA0_S05e00408g	similar to uniprot|Q08144 Saccharomyces cerevisiae YOL018C TLG2 Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)
LALA0_S05e00430g	weakly similar to uniprot|P43595 Saccharomyces cerevisiae YFR012W (ohnolog of YOL019W) Putative protein of unknown function
LALA0_S05e00452g	similar to uniprot|P43594 Saccharomyces cerevisiae YFR011C AIM13 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria; null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome loss
LALA0_S05e00474g	highly similar to uniprot|P43593 Saccharomyces cerevisiae YFR010W UBP6 Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance
LALA0_S05e00496g	highly similar to uniprot|Q08162 Saccharomyces cerevisiae YOL021C DIS3 Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3
LALA0_S05e00518g	highly similar to uniprot|P43535 Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
LALA0_S05e00562g	similar to uniprot|P25040 Saccharomyces cerevisiae YOL022C TSR4 Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
LALA0_S05e00584g	similar to uniprot|P25038 Saccharomyces cerevisiae YOL023W IFM1 Mitochondrial translation initiation factor 2
LALA0_S05e00606g	weakly similar to uniprot|P23180 Saccharomyces cerevisiae YHL021C AIM17 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
LALA0_S05e00628g	weakly similar to uniprot|C5DCQ8 Lachancea thermotolerans KLTH0B05060g hypothetical protein
LALA0_S05e00650g	weakly similar to uniprot|Q92325 Saccharomyces cerevisiae YOL025W LAG2 Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1
LALA0_S05e00672g	highly similar to uniprot|P00560 Saccharomyces cerevisiae YCR012W PGK1 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
LALA0_S05e00694g	similar to uniprot|P25615 Saccharomyces cerevisiae YCR014C POL4 DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
LALA0_S05e00716g	similar to uniprot|P25616 Saccharomyces cerevisiae YCR015C Putative protein of unknown function; YCR015C is not an essential gene
LALA0_S05e00738g	similar to uniprot|P25617 Saccharomyces cerevisiae YCR016W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis
LALA0_S05e00760g	similar to uniprot|P41734 Saccharomyces cerevisiae YOR126C IAH1 Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
LALA0_S05e00782g	similar to uniprot|Q06667 Saccharomyces cerevisiae YDR315C IPK1 Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
LALA0_S05e00804g	highly similar to uniprot|P38791 Saccharomyces cerevisiae YHR068W DYS1 Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
LALA0_S05e00826g	some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p
LALA0_S05e00848g	weakly similar to uniprot|P40342 Saccharomyces cerevisiae YNR004W SWM2 Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds
LALA0_S05e00870g	similar to uniprot|P25618 Saccharomyces cerevisiae YCR017C CWH43 Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
LALA0_S05e00892g	highly similar to uniprot|P32775 Saccharomyces cerevisiae YEL011W GLC3 Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S05e00914g	similar to uniprot|P28263 Saccharomyces cerevisiae YEL012W UBC8 Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
LALA0_S05e00936g	similar to uniprot|Q9URQ5 Saccharomyces cerevisiae YCR020W-B HTL1 Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
LALA0_S05e00958g	similar to uniprot|P23059 Saccharomyces cerevisiae YCR020C-A MAK31 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family
LALA0_S05e00980g	similar to uniprot|P25362 Saccharomyces cerevisiae YCR020C PET18 Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
LALA0_S05e01002g	similar to uniprot|P23060 Saccharomyces cerevisiae YCR019W MAK32 Protein necessary for structural stability of L-A double-stranded RNA-containing particles
LALA0_S05e01046g	highly similar to uniprot|P39968 Saccharomyces cerevisiae YEL013W VAC8 Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
LALA0_S05e01068g	similar to uniprot|P39998 Saccharomyces cerevisiae YEL015W EDC3 Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies
LALA0_S05e01090g	similar to uniprot|P25378 Saccharomyces cerevisiae YCR027C RHB1 Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
LALA0_S05e01112g	weakly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
LALA0_S05e01134g	similar to uniprot|C5E3J9 Lachancea thermotolerans KLTH0H14190g hypothetical protein
LALA0_S05e01156g	weakly similar to uniprot|P39996 Saccharomyces cerevisiae YEL017W GTT3 Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
LALA0_S05e01178g	similar to uniprot|P40975 Saccharomyces cerevisiae YEL017C-A (ohnolog of YCR024C-A) PMP2 Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1
LALA0_S05e01200g	weakly similar to uniprot|P39995 Saccharomyces cerevisiae YEL018W EAF5 Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
LALA0_S05e01222g	similar to uniprot|P38632 Saccharomyces cerevisiae YEL019C MMS21 SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
LALA0_S05e01244g	similar to uniprot|P25345 Saccharomyces cerevisiae YCR024C SLM5 Mitochondrial asparaginyl-tRNA synthetase
LALA0_S05e01266g	similar to uniprot|P39994 Saccharomyces cerevisiae YEL020C Hypothetical protein with low sequence identity to Pdc1p
LALA0_S05e01288g	highly similar to uniprot|O74700 Saccharomyces cerevisiae YEL020W-A TIM9 Essential protein of the mitochondrial intermembrane space, forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
LALA0_S05e01310g	highly similar to uniprot|P03962 Saccharomyces cerevisiae YEL021W URA3 Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound
LALA0_S05e01332g	similar to uniprot|C5E3J9 Lachancea thermotolerans KLTH0H14190g hypothetical protein
LALA0_S05e01354g	similar to uniprot|P39993 Saccharomyces cerevisiae YEL022W (ohnolog of YJR031C) GEA2 Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p
LALA0_S05e01376g	similar to uniprot|P47103 Saccharomyces cerevisiae YJR032W CPR7 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
LALA0_S05e01398g	similar to uniprot|P47104 Saccharomyces cerevisiae YJR033C RAV1 Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
LALA0_S05e01420g	highly similar to uniprot|Q02772 Saccharomyces cerevisiae YJR034W PET191 Protein required for assembly of cytochrome c oxidase; exists as an oligomer that is integral to the mitochondrial inner membrane and faces the intermembrane space; contains a twin Cx9C motif
LALA0_S05e01442g	similar to uniprot|P40352 Saccharomyces cerevisiae YJR035W RAD26 Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
LALA0_S05e01464g	similar to uniprot|P39992 Saccharomyces cerevisiae YEL023C Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
LALA0_S05e01486g	highly similar to uniprot|P08067 Saccharomyces cerevisiae YEL024W RIP1 Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
LALA0_S05e01508g	similar to uniprot|P40985 Saccharomyces cerevisiae YJR036C HUL4 Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
LALA0_S05e01530g	weakly similar to uniprot|P39991 Saccharomyces cerevisiae YEL025C (ohnolog of YJR039W) Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S05e01552g	highly similar to uniprot|P39990 Saccharomyces cerevisiae YEL026W SNU13 RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
LALA0_S05e01574g	similar to uniprot|P37020 Saccharomyces cerevisiae YJR040W GEF1 Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels
LALA0_S05e01596g	weakly similar to uniprot|P47108 Saccharomyces cerevisiae YJR041C URB2 Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
LALA0_S05e01618g	similar to uniprot|P46673 Saccharomyces cerevisiae YJR042W NUP85 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking; the Nup84 subcomplex has a role in transcription elongation
LALA0_S05e01640g	highly similar to uniprot|P25515 Saccharomyces cerevisiae YEL027W VMA3 Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
LALA0_S05e01662g	hypothetical protein
LALA0_S05e01684g	similar to uniprot|P47110 Saccharomyces cerevisiae YJR043C POL32 Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
LALA0_S05e01728g	weakly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
LALA0_S05e01750g	similar to uniprot|P39988 Saccharomyces cerevisiae YEL029C BUD16 Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)
LALA0_S05e01772g	weakly similar to uniprot|P38790 Saccharomyces cerevisiae YHR067W HTD2 Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
LALA0_S05e01794g	similar to uniprot|Q06668 Saccharomyces cerevisiae YDR316W OMS1 Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations
LALA0_S05e01816g	highly similar to uniprot|P38792 Saccharomyces cerevisiae YHR069C RRP4 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
LALA0_S05e01838g	similar to uniprot|P38793 Saccharomyces cerevisiae YHR070W TRM5 tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
LALA0_S05e01860g	similar to uniprot|P38794 Saccharomyces cerevisiae YHR071W PCL5 Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
LALA0_S05e01926g	similar to uniprot|Q99315 Saccharomyces cerevisiae YGR109W-B TY3B-G Transposon Ty3-G Gag-Pol polyprotein
LALA0_S05e01970g	weakly similar to uniprot|Q06674 Saccharomyces cerevisiae YDR317W HIM1 Protein of unknown function involved in DNA repair
LALA0_S05e01992g	weakly similar to uniprot|Q06675 Saccharomyces cerevisiae YDR318W MCM21 Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules
LALA0_S05e02014g	similar to uniprot|Q06676 Saccharomyces cerevisiae YDR319C Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens
LALA0_S05e02036g	similar to uniprot|P38604 Saccharomyces cerevisiae YHR072W ERG7 Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
LALA0_S05e02058g	weakly similar to uniprot|Q06677 Saccharomyces cerevisiae YDR320C SWA2 Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles
LALA0_S05e02080g	highly similar to uniprot|Q6Q547 Saccharomyces cerevisiae YHR072W-A NOP10 Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA
LALA0_S05e02102g	highly similar to uniprot|P69851 Saccharomyces cerevisiae YDR320C-A DAD4 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
LALA0_S05e02124g	similar to uniprot|P38713 Saccharomyces cerevisiae YHR073W OSH3 Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
LALA0_S05e02146g	similar to uniprot|P38986 Saccharomyces cerevisiae YDR321W ASP1 Cytosolic L-asparaginase, involved in asparagine catabolism
LALA0_S05e02168g	highly similar to Lachancea thermotolerans KLTH0H15136g hypothetical protein
LALA0_S05e02190g	highly similar to uniprot|P38795 Saccharomyces cerevisiae YHR074W QNS1 Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
LALA0_S05e02212g	similar to uniprot|P38796 Saccharomyces cerevisiae YHR075C PPE1 Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
LALA0_S05e02234g	some similarities with uniprot|P38704 Saccharomyces cerevisiae YHR006W (ohnolog of YDR463W) STP2 Transcriptionfactor, activated by proteolytic processing in response tosignals from the SPS sensor system for external aminoacids; activates transcription of amino acid permeasegenes
LALA0_S05e02256g	similar to uniprot|Q08760 Saccharomyces cerevisiae YOR301W RAX1 Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
LALA0_S05e02322g	highly similar to uniprot|P07258 Saccharomyces cerevisiae YOR303W CPA1 Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader
LALA0_S05e02344g	similar to Lachancea thermotolerans KLTH0E02244g hypothetical protein
LALA0_S05e02366g	similar to uniprot|Q08773 Saccharomyces cerevisiae YOR304W ISW2 ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
LALA0_S05e02388g	similar to uniprot|Q02555 Saccharomyces cerevisiae YMR239C RNT1 RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; involved in polyadenylation-independent transcription termination
LALA0_S05e02410g	similar to uniprot|Q02554 Saccharomyces cerevisiae YMR240C CUS1 Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
LALA0_S05e02432g	weakly similar to uniprot|O14468 Saccharomyces cerevisiae YOR304C-A Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck
LALA0_S05e02454g	similar to uniprot|Q08774 Saccharomyces cerevisiae YOR305W RRG7 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene
LALA0_S05e02476g	highly similar to uniprot|Q04013 Saccharomyces cerevisiae YMR241W YHM2 Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
LALA0_S05e02498g	similar to uniprot|P22215 Saccharomyces cerevisiae YOR307C SLY41 Protein involved in ER-to-Golgi transport
LALA0_S05e02542g	weakly similar to uniprot|Q12420 Saccharomyces cerevisiae YOR308C SNU66 Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1
LALA0_S05e02564g	similar to uniprot|Q12460 Saccharomyces cerevisiae YLR197W NOP56 Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
LALA0_S05e02586g	similar to uniprot|Q12382 Saccharomyces cerevisiae YOR311C DGK1 Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain
LALA0_S05e02608g	highly similar to uniprot|P0CX24 Saccharomyces cerevisiae YOR312C (ohnolog of YMR242C) RPL20B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
LALA0_S05e02630g	weakly similar to uniprot|P09937 Saccharomyces cerevisiae YOR313C SPS4 Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
LALA0_S05e02652g	weakly similar to uniprot|Q12507 Saccharomyces cerevisiae YOR315W SFG1 Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
LALA0_S05e02674g	similar to uniprot|P32798 Saccharomyces cerevisiae YOR316C (ohnolog of YMR243C) COT1 Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium
LALA0_S05e02696g	similar to uniprot|Q04018 Saccharomyces cerevisiae YMR244W Putative protein of unknown function
LALA0_S05e02718g	similar to uniprot|P25619 Saccharomyces cerevisiae YCR021C HSP30 Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
LALA0_S05e02740g	similar to uniprot|Q3E846 Saccharomyces cerevisiae YMR244C-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene
LALA0_S05e02762g	similar to uniprot|C5DHA9 Lachancea thermotolerans KLTH0E02794g hypothetical protein
LALA0_S05e02784g	weakly similar to uniprot|Q99234 Saccharomyces cerevisiae YOR030W DFG16 Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
LALA0_S05e02828g	weakly similar to uniprot|Q12331 Saccharomyces cerevisiae YDR262W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
LALA0_S05e02850g	some similarities with uniprot|Q12398 Saccharomyces cerevisiae YOR032C HMS1 Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
LALA0_S05e02872g	similar to uniprot|Q12086 Saccharomyces cerevisiae YDR263C (ohnolog of YOR033C) DIN7 Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination
LALA0_S05e02894g	similar to uniprot|P39010 Saccharomyces cerevisiae YDR264C (ohnolog of YOR034C) AKR1 Palmitoyl transferaseinvolved in protein palmitoylation; acts as a negativeregulator of pheromone response pathway; required forendocytosis of pheromone receptors; involved in cell shapecontrol; contains ankyrin repeats
LALA0_S05e02916g	similar to uniprot|P51534 Saccharomyces cerevisiae YOR035C SHE4 Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
LALA0_S05e02938g	similar to uniprot|Q05568 Saccharomyces cerevisiae YDR265W PEX10 Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders
LALA0_S05e02960g	similar to uniprot|Q05580 Saccharomyces cerevisiae YDR266C Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain
LALA0_S05e02982g	similar to uniprot|P38812 Saccharomyces cerevisiae YHR100C GEP4 Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT
LALA0_S05e03004g	highly similar to uniprot|P38811 Saccharomyces cerevisiae YHR099W TRA1 Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation
LALA0_S05e03026g	similar to uniprot|P25346 Saccharomyces cerevisiae YCR098C GIT1 Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
LALA0_S05e03070g	weakly similar to uniprot|Q66RD4 Saccharomyces cerevisiae YDR349C YPS7 Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum
LALA0_S05e03092g	similar to uniprot|P38810 Saccharomyces cerevisiae YHR098C SFB3 Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p
LALA0_S05e03114g	similar to uniprot|P38809 Saccharomyces cerevisiae YHR097C (ohnolog of YDR348C) Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
LALA0_S05e03136g	similar to uniprot|P10662 Saccharomyces cerevisiae YDR347W MRP1 Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
LALA0_S05e03180g	similar to uniprot|Q05515 Saccharomyces cerevisiae YDR346C SVF1 Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance
LALA0_S05e03202g	highly similar to uniprot|P32466 Saccharomyces cerevisiae YDR345C (ohnolog of YHR096C) HXT3 Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
LALA0_S05e03224g	highly similar to uniprot|P13181 Saccharomyces cerevisiae YLR081W GAL2 Galactose permease, required for utilization of galactose; also able to transport glucose
LALA0_S05e03246g	weakly similar to uniprot|C5DHB7 Lachancea thermotolerans KLTH0E02992g hypothetical protein
LALA0_S05e03268g	highly similar to uniprot|P38714 Saccharomyces cerevisiae YHR091C (ohnolog of YDR341C) MSR1 Mitochondrial arginyl-tRNA synthetase
LALA0_S05e03312g	highly similar to uniprot|Q05498 Saccharomyces cerevisiae YDR339C FCF1 Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
LALA0_S05e03334g	weakly similar to uniprot|Q06170 Saccharomyces cerevisiae YLR326W Putative protein of unknown function, predicted to be palmitoylated
LALA0_S05e03356g	similar to uniprot|P38806 Saccharomyces cerevisiae YHR090C YNG2 Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1 and its isoforms ING4 and ING5
LALA0_S05e03378g	similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
LALA0_S05e03400g	weakly similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
LALA0_S05e03422g	similar to uniprot|P21771 Saccharomyces cerevisiae YDR337W MRPS28 Mitochondrial ribosomal protein of the small subunit
LALA0_S05e03444g	similar to uniprot|C5DHD3 Lachancea thermotolerans KLTH0E03432g hypothetical protein
LALA0_S05e03466g	similar to uniprot|P28007 Saccharomyces cerevisiae YHR089C GAR1 Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
LALA0_S05e03488g	similar to uniprot|Q05473 Saccharomyces cerevisiae YDR336W Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
LALA0_S05e03510g	highly similar to uniprot|P52918 Saccharomyces cerevisiae YDR335W MSN5 Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
LALA0_S05e03532g	highly similar to uniprot|P38805 Saccharomyces cerevisiae YHR088W RPF1 Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
LALA0_S05e03554g	similar to uniprot|Q04182 Saccharomyces cerevisiae YDR406W (ohnolog of YOR153W) PDR15 Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
LALA0_S05e03576g	similar to uniprot|C5DHD3 Lachancea thermotolerans KLTH0E03432g hypothetical protein
LALA0_S05e03598g	similar to uniprot|P38804 Saccharomyces cerevisiae YHR087W RTC3 Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
LALA0_S05e03620g	similar to uniprot|Q05471 Saccharomyces cerevisiae YDR334W SWR1 Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
LALA0_S05e03664g	similar to uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre- mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
LALA0_S05e03686g	similar to uniprot|P38803 Saccharomyces cerevisiae YHR085W IPI1 Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
LALA0_S05e03708g	similar to uniprot|Q05468 Saccharomyces cerevisiae YDR333C Putative protein of unknown function
LALA0_S05e03730g	weakly similar to uniprot|P13574 Saccharomyces cerevisiae YHR084W STE12 Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth
LALA0_S05e03752g	similar to uniprot|P14693 Saccharomyces cerevisiae YHR083W SAM35 Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
LALA0_S05e03774g	similar to uniprot|Q06683 Saccharomyces cerevisiae YDR332W IRC3 Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
LALA0_S05e03796g	similar to uniprot|P38691 Saccharomyces cerevisiae YHR082C KSP1 Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10
LALA0_S05e03818g	similar to uniprot|P49018 Saccharomyces cerevisiae YDR331W GPI8 ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
LALA0_S05e03840g	similar to uniprot|Q06682 Saccharomyces cerevisiae YDR330W UBX5 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
LALA0_S05e03862g	similar to uniprot|P38801 Saccharomyces cerevisiae YHR081W LRP1 Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
LALA0_S05e03884g	similar to uniprot|P28795 Saccharomyces cerevisiae YDR329C PEX3 Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p
LALA0_S05e03906g	highly similar to uniprot|P52286 Saccharomyces cerevisiae YDR328C SKP1 Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase
LALA0_S05e03928g	weakly similar to uniprot|P38800 Saccharomyces cerevisiae YHR080C (ohnolog of YDR326C) Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S05e03950g	similar to uniprot|P89114 Saccharomyces cerevisiae YHR079C-A SAE3 Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
LALA0_S05e03972g	similar to uniprot|P32361 Saccharomyces cerevisiae YHR079C IRE1 Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
LALA0_S05e03994g	similar to uniprot|Q06680 Saccharomyces cerevisiae YDR325W YCG1 Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus
LALA0_S05e04016g	similar to uniprot|Q06679 Saccharomyces cerevisiae YDR324C UTP4 Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
LALA0_S05e04038g	similar to uniprot|P38799 Saccharomyces cerevisiae YHR078W High osmolarity-regulated gene of unknown function
LALA0_S05e04060g	similar to uniprot|P32609 Saccharomyces cerevisiae YDR323C PEP7 Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
LALA0_S05e04082g	similar to uniprot|P38798 Saccharomyces cerevisiae YHR077C NMD2 Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance
LALA0_S05e04104g	similar to uniprot|P38797 Saccharomyces cerevisiae YHR076W PTC7 Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope
LALA0_S05e04126g	similar to uniprot|P81449 Saccharomyces cerevisiae YDR322C-A TIM11 Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase
LALA0_S05e04148g	similar to uniprot|Q06678 Saccharomyces cerevisiae YDR322W MRPL35 Mitochondrial ribosomal protein of the large subunit
LALA0_S05e04170g	highly similar to uniprot|Q05031 Saccharomyces cerevisiae YMR238W DFG5 Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p
LALA0_S05e04192g	similar to uniprot|Q08754 Saccharomyces cerevisiae YOR299W (ohnolog of YMR237W) BUD7 Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
LALA0_S05e04214g	similar to uniprot|Q05027 Saccharomyces cerevisiae YMR236W TAF9 Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
LALA0_S05e04236g	highly similar to uniprot|P10622 Saccharomyces cerevisiae YDL130W RPP1B Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component
LALA0_S05e04258g	weakly similar to uniprot|Q07555 Saccharomyces cerevisiae YDL129W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene
LALA0_S05e04280g	similar to uniprot|Q12301 Saccharomyces cerevisiae YDL180W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
LALA0_S05e04302g	highly similar to uniprot|O13581 Saccharomyces cerevisiae YDL128W VCX1 Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
LALA0_S05e04324g	similar to uniprot|P25693 Saccharomyces cerevisiae YDL127W (ohnolog of YDL179W) PCL2 Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth
LALA0_S05e04346g	highly similar to uniprot|P25694 Saccharomyces cerevisiae YDL126C CDC48 ATPase involved in ubiquitin-mediated protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD); along with Npl4-Ufd1 complex, important for maintaining the cell wall integrity during heat stress to allow G1 progression
LALA0_S05e04368g	similar to uniprot|Q04344 Saccharomyces cerevisiae YDL125C HNT1 Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint
LALA0_S05e04390g	highly similar to uniprot|P46681 Saccharomyces cerevisiae YDL178W DLD2 D-lactate dehydrogenase, located in the mitochondrial matrix
LALA0_S05e04412g	similar to uniprot|Q12257 Saccharomyces cerevisiae YDL177C Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
LALA0_S05e04434g	weakly similar to uniprot|Q12027 Saccharomyces cerevisiae YDL176W Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
LALA0_S05e04456g	similar to uniprot|Q12476 Saccharomyces cerevisiae YDL175C (ohnolog of YIL079C) AIR2 Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p
LALA0_S05e04478g	highly similar to uniprot|P04801 Saccharomyces cerevisiae YIL078W THS1 Threonyl-tRNA synthetase, essential cytoplasmic protein
LALA0_S05e04500g	similar to uniprot|P40508 Saccharomyces cerevisiae YIL077C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
LALA0_S05e04522g	similar to uniprot|P40509 Saccharomyces cerevisiae YIL076W SEC28 Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
LALA0_S05e04544g	similar to uniprot|P40056 Saccharomyces cerevisiae YER083C GET2 Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division
LALA0_S05e04566g	highly similar to Lachancea thermotolerans KLTH0A05104g hypothetical protein
LALA0_S05e04588g	highly similar to uniprot|P06780 Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
LALA0_S05e04610g	highly similar to uniprot|P06780 Saccharomyces cerevisiae YPR165W RHO1 GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
LALA0_S05e04632g	highly similar to uniprot|P10663 Saccharomyces cerevisiae YPR166C MRP2 Mitochondrial ribosomal protein of the small subunit
LALA0_S05e04654g	hypothetical protein
LALA0_S05e04676g	highly similar to uniprot|P18408 Saccharomyces cerevisiae YPR167C MET16 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
LALA0_S05e04698g	similar to uniprot|Q06213 Saccharomyces cerevisiae YPR168W NUT2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription
LALA0_S05e04720g	similar to uniprot|Q06214 Saccharomyces cerevisiae YPR169W JIP5 Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein
LALA0_S05e04764g	similar to uniprot|P38925 Saccharomyces cerevisiae YOL122C SMF1 Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
LALA0_S05e04786g	similar to uniprot|Q99383 Saccharomyces cerevisiae YOL123W HRP1 Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
LALA0_S05e04808g	highly similar to uniprot|Q12463 Saccharomyces cerevisiae YOL124C TRM11 Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
LALA0_S05e04830g	similar to uniprot|P48559 Saccharomyces cerevisiae YNL304W YPT11 Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells
LALA0_S05e04852g	similar to uniprot|Q12383 Saccharomyces cerevisiae YOL125W TRM13 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
LALA0_S05e04874g	similar to uniprot|P22133 Saccharomyces cerevisiae YOL126C MDH2 Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
LALA0_S05e04896g	similar to uniprot|P48558 Saccharomyces cerevisiae YNL305C Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
LALA0_S05e04918g	highly similar to uniprot|P04456 Saccharomyces cerevisiae YOL127W RPL25 Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 25S rRNA via a conserved C-terminal motif
LALA0_S05e04940g	similar to uniprot|P42847 Saccharomyces cerevisiae YNL306W MRPS18 Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
LALA0_S05e04962g	highly similar to uniprot|Q12222 Saccharomyces cerevisiae YOL128C (ohnolog of YNL307C) YGK3 Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
LALA0_S05e04984g	highly similar to uniprot|Q12016 Saccharomyces cerevisiae YOL129W VPS68 Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria
LALA0_S05e05006g	similar to uniprot|P42846 Saccharomyces cerevisiae YNL308C KRI1 Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p
LALA0_S05e05028g	similar to uniprot|Q08269 Saccharomyces cerevisiae YOL130W ALR1 Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
LALA0_S05e05050g	weakly similar to uniprot|Q08270 Saccharomyces cerevisiae YOL131W (ohnolog of YNL309W) Putative protein of unknown function
LALA0_S05e05072g	similar to uniprot|P42844 Saccharomyces cerevisiae YNL310C ZIM17 Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix
LALA0_S05e05094g	similar to uniprot|P42843 Saccharomyces cerevisiae YNL311C SKP2 F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
LALA0_S05e05116g	similar to uniprot|Q08271 Saccharomyces cerevisiae YOL132W GAS4 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
LALA0_S05e05138g	similar to uniprot|P26754 Saccharomyces cerevisiae YNL312W RFA2 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
LALA0_S05e05160g	similar to uniprot|P42842 Saccharomyces cerevisiae YNL313C EMW1 Essential conserved protein with a role in maintaining cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1
LALA0_S05e05182g	weakly similar to uniprot|P21705 Saccharomyces cerevisiae YNL314W DAL82 Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
LALA0_S05e05204g	similar to uniprot|P32453 Saccharomyces cerevisiae YNL315C ATP11 Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
LALA0_S05e05226g	similar to uniprot|P32452 Saccharomyces cerevisiae YNL316C PHA2 Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
LALA0_S05e05248g	highly similar to uniprot|Q08273 Saccharomyces cerevisiae YOL133W HRT1 RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF
LALA0_S05e05270g	similar to uniprot|Q08278 Saccharomyces cerevisiae YOL135C MED7 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
LALA0_S05e05292g	similar to uniprot|Q12471 Saccharomyces cerevisiae YOL136C PFK27 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
LALA0_S05e05314g	similar to uniprot|P42841 Saccharomyces cerevisiae YNL317W PFS2 Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
LALA0_S05e05336g	similar to uniprot|Q6B229 Saccharomyces cerevisiae YOL137W BSC6 Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
LALA0_S05e05358g	similar to uniprot|P53153 Saccharomyces cerevisiae YGL085W LCL3 Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS
LALA0_S05e05380g	similar to uniprot|P53154 Saccharomyces cerevisiae YGL084C (ohnolog of YPL189W) GUP1 Plasma membrane proteininvolved in remodeling GPI anchors; member of the MBOATfamily of putative membrane-bound O-acyltransferases;proposed to be involved in glycerol transport
LALA0_S05e05402g	similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S05e05446g	similar to uniprot|P53009 Saccharomyces cerevisiae YGL083W SCY1 Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
LALA0_S05e05468g	similar to uniprot|Q3E823 Saccharomyces cerevisiae YPL189C-A COA2 Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
LALA0_S05e05490g	similar to uniprot|P38996 Saccharomyces cerevisiae YPL190C NAB3 Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p
LALA0_S05e05512g	hypothetical protein
LALA0_S05e05534g	similar to uniprot|P53155 Saccharomyces cerevisiae YGL082W (ohnolog of YPL191C) Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene
LALA0_S05e05556g	weakly similar to uniprot|P53156 Saccharomyces cerevisiae YGL081W Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
LALA0_S05e05578g	weakly similar to uniprot|Q08932 Saccharomyces cerevisiae YPL193W RSA1 Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly
LALA0_S05e05600g	similar to uniprot|P53157 Saccharomyces cerevisiae YGL080W FMP37 Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S05e05622g	similar to uniprot|Q08949 Saccharomyces cerevisiae YPL194W DDC1 DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate
LALA0_S05e05644g	similar to uniprot|Q7LIB1 Saccharomyces cerevisiae YPL195W APL5 Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
LALA0_S05e05666g	weakly similar to uniprot|P53158 Saccharomyces cerevisiae YGL079W KXD1 Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
LALA0_S05e05688g	similar to uniprot|Q08952 Saccharomyces cerevisiae YPL196W OXR1 Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes
LALA0_S05e05710g	similar to uniprot|C5E2F3 Lachancea thermotolerans KLTH0H04488g hypothetical protein
LALA0_S05e05732g	highly similar to uniprot|P20447 Saccharomyces cerevisiae YGL078C DBP3 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
LALA0_S05e05754g	similar to uniprot|P19807 Saccharomyces cerevisiae YGL077C HNM1 Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
LALA0_S05e05776g	highly similar to uniprot|P05737 Saccharomyces cerevisiae YGL076C (ohnolog of YPL198W) RPL7A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
LALA0_S05e05798g	hypothetical protein
LALA0_S05e05820g	similar to uniprot|Q08954 Saccharomyces cerevisiae YPL199C Putative protein of unknown function, predicted to be palmitoylated
LALA0_S05e05842g	weakly similar to uniprot|P53159 Saccharomyces cerevisiae YGL075C (ohnolog of YPL200W CSM4) MPS2 Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
LALA0_S05e05864g	weakly similar to uniprot|P10961 Saccharomyces cerevisiae YGL073W HSF1 Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
LALA0_S05e05886g	weakly similar to uniprot|Q08956 Saccharomyces cerevisiae YPL201C YIG1 Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
LALA0_S05e05908g	weakly similar to uniprot|P22149 Saccharomyces cerevisiae YGL071W (ohnolog of YPL202C) AFT1 Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
LALA0_S05e05930g	highly similar to uniprot|P27999 Saccharomyces cerevisiae YGL070C RPB9 RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription
LALA0_S05e05952g	similar to uniprot|P53163 Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
LALA0_S05e05974g	highly similar to uniprot|P06245 Saccharomyces cerevisiae YPL203W TPK2 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase
LALA0_S05e05996g	similar to uniprot|P29295 Saccharomyces cerevisiae YPL204W HRR25 Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
LALA0_S05e06018g	similar to uniprot|P53164 Saccharomyces cerevisiae YGL067W NPY1 NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes
LALA0_S05e06040g	similar to uniprot|Q08959 Saccharomyces cerevisiae YPL206C PGC1 Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs
LALA0_S05e06062g	similar to uniprot|P53165 Saccharomyces cerevisiae YGL066W SGF73 SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
LALA0_S05e06084g	similar to uniprot|P43636 Saccharomyces cerevisiae YGL065C ALG2 Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
LALA0_S05e06106g	similar to uniprot|C5E2D5 Lachancea thermotolerans KLTH0H04048g hypothetical protein
LALA0_S05e06128g	similar to uniprot|Q08960 Saccharomyces cerevisiae YPL207W TYW1 Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
LALA0_S05e06150g	similar to uniprot|Q08961 Saccharomyces cerevisiae YPL208W RKM1 SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B)
LALA0_S05e06172g	similar to uniprot|P38991 Saccharomyces cerevisiae YPL209C IPL1 Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase
LALA0_S05e06194g	similar to uniprot|P53166 Saccharomyces cerevisiae YGL064C MRH4 Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
LALA0_S05e06216g	similar to uniprot|P38688 Saccharomyces cerevisiae YPL210C SRP72 Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
LALA0_S05e06238g	highly similar to uniprot|Q08962 Saccharomyces cerevisiae YPL211W NIP7 Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
LALA0_S05e06260g	similar to uniprot|P53167 Saccharomyces cerevisiae YGL063W (ohnolog of YPL212C) PUS2 Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
LALA0_S05e06282g	similar to uniprot|Q01163 Saccharomyces cerevisiae YGL129C RSM23 Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
LALA0_S05e06304g	similar to uniprot|Q01159 Saccharomyces cerevisiae YGL130W CEG1 Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
LALA0_S05e06326g	similar to uniprot|P53127 Saccharomyces cerevisiae YGL131C SNT2 DNA binding protein with similarity to the S. pombe Snt2 protein; computational analysis suggests a role in regulation of expression of genes encoding amine transporters
LALA0_S05e06348g	similar to uniprot|Q08963 Saccharomyces cerevisiae YPL213W LEA1 Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein
LALA0_S05e06370g	similar to uniprot|P41835 Saccharomyces cerevisiae YPL214C THI6 Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S05e06392g	similar to uniprot|P21560 Saccharomyces cerevisiae YPL215W CBP3 Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
LALA0_S05e06414g	similar to uniprot|P53125 Saccharomyces cerevisiae YGL133W (ohnolog of YPL216W) ITC1 Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex
LALA0_S05e06436g	highly similar to uniprot|Q08965 Saccharomyces cerevisiae YPL217C BMS1 GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p
LALA0_S05e06458g	highly similar to uniprot|P20606 Saccharomyces cerevisiae YPL218W SAR1 GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
LALA0_S05e06480g	weakly similar to uniprot|P53124 Saccharomyces cerevisiae YGL134W (ohnolog of YPL219W) PCL10 Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
LALA0_S05e06502g	highly similar to uniprot|P0CX44 Saccharomyces cerevisiae YGL135W (ohnolog of YPL220W) RPL1B N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
LALA0_S05e06524g	similar to uniprot|P53123 Saccharomyces cerevisiae YGL136C MRM2 Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
LALA0_S05e06546g	highly similar to uniprot|P41811 Saccharomyces cerevisiae YGL137W SEC27 Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
LALA0_S05e06568g	weakly similar to uniprot|P53122 Saccharomyces cerevisiae YGL138C Putative protein of unknown function; has no significant sequence similarity to any known protein
LALA0_S05e06590g	similar to uniprot|P53121 Saccharomyces cerevisiae YGL139W (ohnolog of YPL221W) FLC3 Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
LALA0_S05e06612g	weakly similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
LALA0_S05e06634g	similar to uniprot|Q08968 Saccharomyces cerevisiae YPL222W FMP40 Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S05e06656g	weakly similar to uniprot|Q03213 Saccharomyces cerevisiae YMR172W HOT1 Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
LALA0_S05e06678g	some similarities with uniprot|P18899 Saccharomyces cerevisiae YMR173W DDR48 DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS
LALA0_S05e06700g	hypothetical protein
LALA0_S05e06722g	similar to Lachancea thermotolerans KLTH0H03212g hypothetical protein
LALA0_S05e06744g	weakly similar to uniprot|Q03214 Saccharomyces cerevisiae YMR176W ECM5 Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks
LALA0_S05e06766g	similar to uniprot|Q08970 Saccharomyces cerevisiae YPL224C (ohnolog of YMR177W) MMT2 Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p
LALA0_S05e06788g	highly similar to uniprot|Q08971 Saccharomyces cerevisiae YPL225W Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S05e06810g	similar to uniprot|Q03219 Saccharomyces cerevisiae YMR178W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene
LALA0_S05e06832g	highly similar to uniprot|Q7LHP2 Saccharomyces cerevisiae YPL226W NEW1 ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction
LALA0_S05e06854g	weakly similar to uniprot|P35209 Saccharomyces cerevisiae YMR179W SPT21 Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p
LALA0_S05e06876g	similar to uniprot|P40350 Saccharomyces cerevisiae YPL227C ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
LALA0_S05e06898g	similar to uniprot|O13297 Saccharomyces cerevisiae YPL228W (ohnolog of YMR180C) CET1 Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
LALA0_S05e06920g	similar to uniprot|C5E284 Lachancea thermotolerans KLTH0H02904g hypothetical protein
LALA0_S05e06942g	highly similar to uniprot|P19097 Saccharomyces cerevisiae YPL231W FAS2 Alpha subunit of fatty acidsynthetase, which catalyzes the synthesis of long-chainsaturated fatty acids; contains the acyl-carrier proteindomain and beta-ketoacyl reductase, beta-ketoacyl synthaseand self-pantetheinylation activities
LALA0_S05e06964g	highly similar to uniprot|P32867 Saccharomyces cerevisiae YPL232W (ohnolog of YMR183C) SSO1 Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
LALA0_S05e06986g	similar to uniprot|Q6B152 Saccharomyces cerevisiae YPL233W NSL1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
LALA0_S05e07008g	highly similar to uniprot|P32842 Saccharomyces cerevisiae YPL234C VMA11 Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen
LALA0_S05e07030g	highly similar to uniprot|Q12464 Saccharomyces cerevisiae YPL235W RVB2 Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as reptin; member of the RUVB-like protein family
LALA0_S05e07052g	similar to uniprot|Q7LGU7 Saccharomyces cerevisiae YPL236C Putative protein of unknown function
LALA0_S05e07074g	similar to uniprot|Q03233 Saccharomyces cerevisiae YMR184W ADD37 Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene
LALA0_S05e07096g	highly similar to uniprot|P09064 Saccharomyces cerevisiae YPL237W SUI3 Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
LALA0_S05e07118g	similar to uniprot|P46683 Saccharomyces cerevisiae YPL239W YAR1 Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
LALA0_S05e07140g	similar to uniprot|Q12751 Saccharomyces cerevisiae YMR185W Putative protein of unknown function; conflicting evidence on whether null mutant is viable with elongated buds, or inviable
LALA0_S05e07162g	highly similar to uniprot|P02829 Saccharomyces cerevisiae YPL240C (ohnolog of YMR186W) HSP82 Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
LALA0_S05e07184g	weakly similar to uniprot|P46670 Saccharomyces cerevisiae YPL241C CIN2 GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
LALA0_S05e07206g	similar to uniprot|Q12280 Saccharomyces cerevisiae YPL242C IQG1 Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family
LALA0_S05e07228g	similar to uniprot|C5E269 Lachancea thermotolerans KLTH0H02574g hypothetical protein
LALA0_S05e07250g	similar to uniprot|P38687 Saccharomyces cerevisiae YPL243W SRP68 Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
LALA0_S05e07272g	similar to uniprot|Q12520 Saccharomyces cerevisiae YPL244C HUT1 Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
LALA0_S05e07294g	similar to uniprot|Q12270 Saccharomyces cerevisiae YPL246C RBD2 Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
LALA0_S05e07316g	similar to uniprot|Q03246 Saccharomyces cerevisiae YMR188C MRPS17 Mitochondrial ribosomal protein of the small subunit
LALA0_S05e07338g	similar to uniprot|Q12523 Saccharomyces cerevisiae YPL247C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest
LALA0_S05e07360g	highly similar to uniprot|P49095 Saccharomyces cerevisiae YMR189W GCV2 P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
LALA0_S05e07382g	similar to uniprot|P39709 Saccharomyces cerevisiae YAL067C SEO1 Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
LALA0_S05e07404g	similar to uniprot|P35187 Saccharomyces cerevisiae YMR190C SGS1 Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes
LALA0_S05e07426g	weakly similar to uniprot|P04386 Saccharomyces cerevisiae YPL248C GAL4 DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
LALA0_S05e07448g	weakly similar to uniprot|P42933 Saccharomyces cerevisiae YMR191W SPG5 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
LALA0_S05e07470g	similar to uniprot|Q12344 Saccharomyces cerevisiae YPL249C (ohnolog of YMR192W) GYP5 GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth
LALA0_S05e07492g	highly similar to uniprot|P36525 Saccharomyces cerevisiae YMR193W MRPL24 Mitochondrial ribosomal protein of the large subunit
LALA0_S05e07514g	highly similar to uniprot|O14455 Saccharomyces cerevisiae YPL249C-A (ohnolog of YMR194W) RPL36B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
LALA0_S05e07536g	similar to Lachancea thermotolerans KLTH0H02508g hypothetical protein
LALA0_S05e07558g	similar to uniprot|Q3E7A9 Saccharomyces cerevisiae YMR194C-B CMC4 Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs
LALA0_S05e07580g	some similarities with uniprot|P01098 Saccharomyces cerevisiae YDL130W-A (ohnolog of YDL181W) STF1 Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
LALA0_S05e07602g	similar to uniprot|C5E258 Lachancea thermotolerans KLTH0H02332g hypothetical protein
LALA0_S05e07624g	highly similar to uniprot|Q12122 Saccharomyces cerevisiae YDL131W (ohnolog of YDL182W) LYS21 Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p
LALA0_S05e07646g	similar to uniprot|Q12018 Saccharomyces cerevisiae YDL132W CDC53 Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
LALA0_S05e07668g	similar to uniprot|Q12516 Saccharomyces cerevisiae YDL133W SRF1 Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
LALA0_S05e07690g	similar to uniprot|P48569 Saccharomyces cerevisiae YDL183C Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
LALA0_S05e07734g	some similarities with uniprot|Q6FQS3 Saccharomyces cerevisiae YDL185W VMA1 Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
LALA0_S05e07756g	weakly similar to uniprot|P48568 Saccharomyces cerevisiae YDL186W Putative protein of unknown function; YDL186W is not an essential gene
LALA0_S05e07778g	highly similar to uniprot|P23594 Saccharomyces cerevisiae YDL134C (ohnolog of YDL188C) PPH21 Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
LALA0_S05e07800g	similar to uniprot|C5E256 Lachancea thermotolerans KLTH0H02288g hypothetical protein
LALA0_S05e07822g	highly similar to uniprot|Q12434 Saccharomyces cerevisiae YDL135C RDI1 Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p and Rho1p
LALA0_S05e07844g	similar to uniprot|C5E219 Lachancea thermotolerans KLTH0H01474g hypothetical protein
LALA0_S05e07866g	highly similar to uniprot|P54860 Saccharomyces cerevisiae YDL190C UFD2 Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
LALA0_S05e07888g	highly similar to uniprot|P0CX85 Saccharomyces cerevisiae YDL136W (ohnolog of YDL191W) RPL35B Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein
LALA0_S05e07910g	highly similar to uniprot|P11076 Saccharomyces cerevisiae YDL192W (ohnolog of YDL137W) ARF1 ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
LALA0_S05e07932g	similar to uniprot|Q12063 Saccharomyces cerevisiae YDL193W NUS1 Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY
LALA0_S05e07954g	similar to uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p
LALA0_S05e07976g	similar to uniprot|P38968 Saccharomyces cerevisiae YDL195W SEC31 Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
LALA0_S05e07998g	some similarities with uniprot|Q05809 Saccharomyces cerevisiae YLR218C COA4 Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors
LALA0_S05e08020g	similar to uniprot|Q12334 Saccharomyces cerevisiae YDL139C SCM3 Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation
LALA0_S05e08042g	highly similar to uniprot|P53691 Saccharomyces cerevisiae YLR216C CPR6 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
LALA0_S05e08064g	weakly similar to uniprot|P04051 Saccharomyces cerevisiae YOR116C RPO31 RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
LALA0_S05e08086g	similar to uniprot|P48445 Saccharomyces cerevisiae YDL141W BPL1 Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
LALA0_S05e08108g	similar to uniprot|Q07560 Saccharomyces cerevisiae YDL142C CRD1 Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis
LALA0_S05e08130g	highly similar to uniprot|P39078 Saccharomyces cerevisiae YDL143W CCT4 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
LALA0_S05e08152g	similar to uniprot|Q05791 Saccharomyces cerevisiae YLR215C CDC123 Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein
LALA0_S05e08174g	similar to uniprot|P32791 Saccharomyces cerevisiae YLR214W FRE1 Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
LALA0_S05e08196g	similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene.
LALA0_S05e08218g	similar to uniprot|Q05790 Saccharomyces cerevisiae YLR213C CRR1 Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
LALA0_S05e08240g	highly similar to uniprot|P53622 Saccharomyces cerevisiae YDL145C COP1 Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
LALA0_S05e08262g	similar to uniprot|P53378 Saccharomyces cerevisiae YLR212C TUB4 Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
LALA0_S05e08284g	similar to uniprot|Q12342 Saccharomyces cerevisiae YDL146W LDB17 Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
LALA0_S05e08306g	weakly similar to uniprot|Q05789 Saccharomyces cerevisiae YLR211C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
LALA0_S05e08328g	highly similar to uniprot|Q12250 Saccharomyces cerevisiae YDL147W RPN5 Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein
LALA0_S05e08350g	similar to uniprot|Q99207 Saccharomyces cerevisiae YDL148C NOP14 Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
LALA0_S05e08372g	similar to uniprot|Q12142 Saccharomyces cerevisiae YDL149W ATG9 Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS
LALA0_S05e08394g	similar to uniprot|P25441 Saccharomyces cerevisiae YDL150W RPC53 RNA polymerase III subunit C53
LALA0_S05e08416g	similar to uniprot|Q05842 Saccharomyces cerevisiae YDL153C SAS10 Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
LALA0_S05e08438g	similar to uniprot|P24870 Saccharomyces cerevisiae YDL155W (ohnolog of YLR210W) CLB3 B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
LALA0_S05e08460g	weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W (ohnolog of YOR363C) OAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
LALA0_S05e08482g	similar to uniprot|Q04170 Saccharomyces cerevisiae YDR391C Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S05e08504g	similar to uniprot|Q12510 Saccharomyces cerevisiae YDL156W Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the YDL156W promoter region
LALA0_S05e08526g	similar to uniprot|Q12082 Saccharomyces cerevisiae YDL157C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S05e08548g	similar to uniprot|P06784 Saccharomyces cerevisiae YDL159W STE7 Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway
LALA0_S05e08570g	highly similar to uniprot|P39517 Saccharomyces cerevisiae YDL160C DHH1 Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation
LALA0_S05e08592g	similar to uniprot|Q05788 Saccharomyces cerevisiae YLR209C PNP1 Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway
LALA0_S05e08614g	highly similar to uniprot|Q04491 Saccharomyces cerevisiae YLR208W SEC13 Component of the Nup84 nuclear pore sub-complex, the Sec13p-Sec31p complex of the COPII vesicle coat, and the SEA (Seh1-associated) complex; required for vesicle formation in ER to Golgi transport and nuclear pore complex organization; the Nup84 subcomplex has a role in transcription elongation
LALA0_S05e08636g	similar to uniprot|Q05787 Saccharomyces cerevisiae YLR207W HRD3 Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
LALA0_S05e08658g	similar to uniprot|C5E214 Lachancea thermotolerans KLTH0H01364g hypothetical protein
LALA0_S05e08680g	similar to uniprot|Q3E829 Saccharomyces cerevisiae YDL160C-A Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF2, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability
LALA0_S05e08702g	similar to uniprot|Q12518 Saccharomyces cerevisiae YDL161W (ohnolog of YLR206W) ENT1 Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus
LALA0_S05e08724g	similar to uniprot|P04819 Saccharomyces cerevisiae YDL164C CDC9 DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
LALA0_S05e08746g	similar to uniprot|P32339 Saccharomyces cerevisiae YLR205C HMX1 ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
LALA0_S05e08768g	similar to uniprot|C5E214 Lachancea thermotolerans KLTH0H01364g hypothetical protein
LALA0_S05e08790g	highly similar to uniprot|P32335 Saccharomyces cerevisiae YLR203C MSS51 Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase
LALA0_S05e08812g	highly similar to uniprot|P06100 Saccharomyces cerevisiae YDL165W CDC36 Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
LALA0_S05e08834g	similar to uniprot|Q12055 Saccharomyces cerevisiae YDL166C FAP7 Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
LALA0_S05e08856g	similar to uniprot|P32770 Saccharomyces cerevisiae YDL167C NRP1 Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis
LALA0_S05e08878g	highly similar to uniprot|P32771 Saccharomyces cerevisiae YDL168W SFA1 Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p
LALA0_S05e08900g	similar to uniprot|Q05779 Saccharomyces cerevisiae YLR201C COQ9 Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
LALA0_S05e08922g	similar to uniprot|P52553 Saccharomyces cerevisiae YLR200W YKE2 Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
LALA0_S05e08944g	similar to uniprot|Q05778 Saccharomyces cerevisiae YLR199C PBA1 Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
LALA0_S05e08966g	highly similar to uniprot|Q12460 Saccharomyces cerevisiae YLR197W NOP56 Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
LALA0_S05e08988g	weakly similar to uniprot|P32772 Saccharomyces cerevisiae YDL169C UGX2 Protein of unknown function, transcript accumulates in response to any combination of stress conditions
LALA0_S05e09010g	similar to uniprot|P21304 Saccharomyces cerevisiae YLR196W PWP1 Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
LALA0_S05e09032g	highly similar to uniprot|P14743 Saccharomyces cerevisiae YLR195C NMT1 N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
LALA0_S05e09054g	weakly similar to uniprot|Q05777 Saccharomyces cerevisiae YLR194C Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress
LALA0_S05e09076g	similar to uniprot|Q05776 Saccharomyces cerevisiae YLR193C UPS1 Mitochondrial intermembrane space protein that regulates mitochondrial cardiolipin levels, null has defects in Mgm1p processing, integrity of mitochondrial inner membrane complexes, and mitochondrial morphology; ortholog of human PRELI
LALA0_S05e09098g	weakly similar to uniprot|P26370 Saccharomyces cerevisiae YDL170W UGA3 Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
LALA0_S05e09120g	similar to uniprot|P53314 Saccharomyces cerevisiae YGR247W CPD1 Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression
LALA0_S05e09142g	similar to uniprot|P29056 Saccharomyces cerevisiae YGR246C BRF1 TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
LALA0_S05e09164g	highly similar to uniprot|P53313 Saccharomyces cerevisiae YGR245C SDA1 Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
LALA0_S05e09186g	highly similar to uniprot|P53312 Saccharomyces cerevisiae YGR244C LSC2 Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
LALA0_S05e09208g	similar to uniprot|P38857 Saccharomyces cerevisiae YHR162W (ohnolog of YGR243W) Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
LALA0_S05e09252g	similar to uniprot|P38858 Saccharomyces cerevisiae YHR163W (ohnolog of YGR248W) SOL3 6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p
LALA0_S05e09274g	weakly similar to uniprot|P53050 Saccharomyces cerevisiae YGR249W MGA1 Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
LALA0_S05e09296g	similar to uniprot|P53316 Saccharomyces cerevisiae YGR250C Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid
LALA0_S05e09318g	similar to uniprot|P38859 Saccharomyces cerevisiae YHR164C DNA2 Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization
LALA0_S05e09340g	hypothetical protein
LALA0_S05e09362g	highly similar to uniprot|W9XS86 Capronia coronata A1O1_07019 hypothetical protein
LALA0_S05e09384g	similar to uniprot|P16522 Saccharomyces cerevisiae YHR166C CDC23 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
LALA0_S05e09406g	weakly similar to uniprot|O13539 Saccharomyces cerevisiae YHR167W THP2 Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance
LALA0_S05e09428g	similar to uniprot|P38860 Saccharomyces cerevisiae YHR168W MTG2 Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
LALA0_S05e09450g	highly similar to uniprot|P38719 Saccharomyces cerevisiae YHR169W DBP8 ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p
LALA0_S05e09472g	similar to uniprot|P53317 Saccharomyces cerevisiae YGR251W Essential protein required for maturation of 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus
LALA0_S05e09494g	highly similar to uniprot|P38861 Saccharomyces cerevisiae YHR170W NMD3 Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
LALA0_S05e09516g	similar to uniprot|P38862 Saccharomyces cerevisiae YHR171W ATG7 Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation
LALA0_S05e09538g	highly similar to uniprot|Q03330 Saccharomyces cerevisiae YGR252W GCN5 Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
LALA0_S05e09560g	highly similar to uniprot|P32379 Saccharomyces cerevisiae YGR253C PUP2 Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
LALA0_S05e09582g	similar to uniprot|P32259 Saccharomyces cerevisiae YNL236W SIN4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
LALA0_S05e09604g	similar to uniprot|P53584 Saccharomyces cerevisiae YNL237W YTP1 Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
LALA0_S05e09626g	similar to uniprot|P13134 Saccharomyces cerevisiae YNL238W KEX2 Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
LALA0_S05e09648g	similar to uniprot|P23503 Saccharomyces cerevisiae YNL240C NAR1 Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf
LALA0_S05e09670g	highly similar to uniprot|P11412 Saccharomyces cerevisiae YNL241C ZWF1 Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia
LALA0_S05e09692g	similar to uniprot|P35688 Saccharomyces cerevisiae YDL240W LRG1 Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
LALA0_S05e09714g	similar to uniprot|P53855 Saccharomyces cerevisiae YNL242W ATG2 Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria
LALA0_S05e09736g	some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p
LALA0_S05e09758g	weakly similar to uniprot|P53857 Saccharomyces cerevisiae YNL234W Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1
LALA0_S05e09780g	weakly similar to uniprot|P38125 Saccharomyces cerevisiae YBR180W DTR1 Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
LALA0_S05e09802g	similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene.
LALA0_S05e09824g	similar to uniprot|C5DGZ8 Lachancea thermotolerans KLTH0E00154g putative inosine/uridine hydrolase
LALA0_S05e09846g	similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
LALA0_S05e09868g	weakly similar to uniprot|P07272 Saccharomyces cerevisiae YLR014C PPR1 Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p
LALA0_S05e09890g	some similarities with Lachancea thermotolerans KLTH0C00440g hypothetical protein
LALA0_S06e00100g	weakly similar to uniprot|Q07629 Saccharomyces cerevisiae YDL218W Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
LALA0_S06e00122g	similar to uniprot|P38360 Saccharomyces cerevisiae YBR295W PCA1 Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function
LALA0_S06e00144g	similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 Proline permease, required for high-affinitytransport of proline; also transports the toxic prolineanalog azetidine-2-carboxylate (AzC); PUT4 transcriptionis repressed in ammonia-grown cells
LALA0_S06e00166g	similar to uniprot|P00724 Saccharomyces cerevisiae YIL162W SUC2 Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
LALA0_S06e00188g	similar to uniprot|P39676 Saccharomyces cerevisiae YGR234W YHB1 Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
LALA0_S06e00210g	similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase
LALA0_S06e00232g	highly similar to uniprot|P40582 Saccharomyces cerevisiae YIR038C GTT1 ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
LALA0_S06e00254g	highly similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein
LALA0_S06e00276g	highly similar to uniprot|P23641 Saccharomyces cerevisiae YJR077C MIR1 Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
LALA0_S06e00298g	similar to uniprot|P36036 Saccharomyces cerevisiae YKL214C YRA2 Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
LALA0_S06e00320g	similar to uniprot|P36037 Saccharomyces cerevisiae YKL213C DOA1 WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
LALA0_S06e00342g	similar to uniprot|P32368 Saccharomyces cerevisiae YKL212W SAC1 Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmembrane protein localizes to ER and Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance
LALA0_S06e00364g	highly similar to uniprot|P00937 Saccharomyces cerevisiae YKL211C TRP3 Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
LALA0_S06e00386g	highly similar to uniprot|P32458 Saccharomyces cerevisiae YJR076C CDC11 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
LALA0_S06e00408g	similar to uniprot|P47124 Saccharomyces cerevisiae YJR075W HOC1 Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
LALA0_S06e00430g	similar to uniprot|P47123 Saccharomyces cerevisiae YJR074W MOG1 Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
LALA0_S06e00474g	highly similar to uniprot|P22515 Saccharomyces cerevisiae YKL210W UBA1 Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability
LALA0_S06e00496g	similar to uniprot|P12866 Saccharomyces cerevisiae YKL209C STE6 Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
LALA0_S06e00518g	similar to uniprot|P05375 Saccharomyces cerevisiae YJR073C OPI3 Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
LALA0_S06e00540g	highly similar to uniprot|P42942 Saccharomyces cerevisiae YGR210C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S06e00562g	similar to uniprot|P53388 Saccharomyces cerevisiae YPL265W DIP5 Dicarboxylic amino acid permease, mediateshigh-affinity and high-capacity transport of L-glutamateand L-aspartate; also a transporter for Gln, Asn, Ser,Ala, and Gly
LALA0_S06e00584g	weakly similar to uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
LALA0_S06e00606g	weakly similar to uniprot|P52924 Saccharomyces cerevisiae YNR075W COS10 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
LALA0_S06e00628g	weakly similar to uniprot|P52924 Saccharomyces cerevisiae YNR075W COS10 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
LALA0_S06e00650g	weakly similar to uniprot|P52924 Saccharomyces cerevisiae YNR075W COS10 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
LALA0_S06e00672g	weakly similar to uniprot|P52924 Saccharomyces cerevisiae YNR075W COS10 Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
LALA0_S06e00694g	highly similar to uniprot|P06169 Saccharomyces cerevisiae YLR044C PDC1 Major of three pyruvatedecarboxylase isozymes, key enzyme in alcoholicfermentation, decarboxylates pyruvate to acetaldehyde;subject to glucose-, ethanol-, and autoregulation;involved in amino acid catabolism
LALA0_S06e00716g	similar to uniprot|P16451 Saccharomyces cerevisiae YGR193C PDX1 Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
LALA0_S06e00738g	similar to uniprot|P42826 Saccharomyces cerevisiae YGR194C XKS1 Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
LALA0_S06e00760g	similar to uniprot|P46965 Saccharomyces cerevisiae YJR010C-A SPC1 Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex
LALA0_S06e00782g	weakly similar to uniprot|P47086 Saccharomyces cerevisiae YJR011C Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
LALA0_S06e00804g	weakly similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W (ohnolog of YPR058W) YMC2 Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
LALA0_S06e00826g	some similarities with uniprot|P47087 Saccharomyces cerevisiae YJR012C Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
LALA0_S06e00848g	similar to uniprot|P47088 Saccharomyces cerevisiae YJR013W GPI14 Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
LALA0_S06e00870g	highly similar to uniprot|P46948 Saccharomyces cerevisiae YGR195W SKI6 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
LALA0_S06e00892g	weakly similar to uniprot|P46949 Saccharomyces cerevisiae YGR196C FYV8 Protein of unknown function, required for survival upon exposure to K1 killer toxin
LALA0_S06e00914g	highly similar to uniprot|P47089 Saccharomyces cerevisiae YJR014W TMA22 Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1
LALA0_S06e00936g	similar to uniprot|P46951 Saccharomyces cerevisiae YGR198W YPP1 Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
LALA0_S06e00958g	similar to uniprot|P42934 Saccharomyces cerevisiae YGR199W PMT6 Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases
LALA0_S06e00980g	similar to uniprot|P42935 Saccharomyces cerevisiae YGR200C ELP2 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
LALA0_S06e01002g	highly similar to uniprot|P39522 Saccharomyces cerevisiae YJR016C ILV3 Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
LALA0_S06e01024g	similar to uniprot|P13259 Saccharomyces cerevisiae YGR202C PCT1 Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding
LALA0_S06e01046g	similar to uniprot|P42937 Saccharomyces cerevisiae YGR203W YCH1 Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S06e01068g	similar to uniprot|P22696 Saccharomyces cerevisiae YJR017C ESS1 Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain
LALA0_S06e01090g	similar to uniprot|P07245 Saccharomyces cerevisiae YGR204W ADE3 Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
LALA0_S06e01112g	similar to uniprot|P41903 Saccharomyces cerevisiae YJR019C TES1 Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
LALA0_S06e01134g	similar to uniprot|P42938 Saccharomyces cerevisiae YGR205W TDA10 ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
LALA0_S06e01156g	weakly similar to uniprot|P21651 Saccharomyces cerevisiae YJR021C REC107 Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation
LALA0_S06e01178g	similar to uniprot|P47093 Saccharomyces cerevisiae YJR022W LSM8 Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
LALA0_S06e01200g	similar to uniprot|P47095 Saccharomyces cerevisiae YJR024C MDE1 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant
LALA0_S06e01222g	highly similar to uniprot|P47096 Saccharomyces cerevisiae YJR025C BNA1 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
LALA0_S06e01244g	weakly similar to uniprot|P42939 Saccharomyces cerevisiae YGR206W MVB12 ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
LALA0_S06e01266g	highly similar to uniprot|P42940 Saccharomyces cerevisiae YGR207C CIR1 Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
LALA0_S06e01288g	similar to uniprot|P42941 Saccharomyces cerevisiae YGR208W SER2 Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
LALA0_S06e01310g	highly similar to uniprot|P22803 Saccharomyces cerevisiae YGR209C (ohnolog of YLR043C) TRX2 Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance
LALA0_S06e01354g	similar to uniprot|P46675 Saccharomyces cerevisiae YLR045C STU2 Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
LALA0_S06e01376g	similar to uniprot|C5DCD0 Lachancea thermotolerans KLTH0B02024g hypothetical protein
LALA0_S06e01398g	highly similar to uniprot|P08536 Saccharomyces cerevisiae YJR010W MET3 ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
LALA0_S06e01420g	similar to uniprot|P47085 Saccharomyces cerevisiae YJR008W Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source.
LALA0_S06e01442g	highly similar to uniprot|P20459 Saccharomyces cerevisiae YJR007W SUI2 Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP
LALA0_S06e01464g	similar to uniprot|C5DCF3 Lachancea thermotolerans KLTH0B02596g hypothetical protein
LALA0_S06e01508g	similar to uniprot|P53301 Saccharomyces cerevisiae YGR189C CRH1 Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
LALA0_S06e01552g	similar to uniprot|P47076 Saccharomyces cerevisiae YJL011C RPC17 RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
LALA0_S06e01574g	highly similar to uniprot|P47075 Saccharomyces cerevisiae YJL012C VTC4 Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion
LALA0_S06e01596g	similar to uniprot|P47074 Saccharomyces cerevisiae YJL013C (ohnolog of YGR188C) MAD3 Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
LALA0_S06e01618g	highly similar to uniprot|P39077 Saccharomyces cerevisiae YJL014W CCT3 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
LALA0_S06e01640g	weakly similar to uniprot|P47071 Saccharomyces cerevisiae YJL016W Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species
LALA0_S06e01662g	similar to uniprot|P47069 Saccharomyces cerevisiae YJL019W MPS3 Nuclear envelope protein required for SPB duplication and nuclear fusion; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere- led rapid prophase movement
LALA0_S06e01684g	similar to uniprot|P53292 Saccharomyces cerevisiae YGR165W MRPS35 Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
LALA0_S06e01706g	weakly similar to uniprot|P32893 Saccharomyces cerevisiae YGR166W TRS65 Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
LALA0_S06e01728g	similar to uniprot|P17891 Saccharomyces cerevisiae YGR167W CLC1 Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component
LALA0_S06e01750g	weakly similar to uniprot|P53293 Saccharomyces cerevisiae YGR168C Putative protein of unknown function; YGR168C is not an essential gene
LALA0_S06e01772g	weakly similar to uniprot|P47068 Saccharomyces cerevisiae YJL020C BBC1 Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
LALA0_S06e01794g	similar to uniprot|P53294 Saccharomyces cerevisiae YGR169C PUS6 tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
LALA0_S06e01816g	weakly similar to uniprot|P47065 Saccharomyces cerevisiae YJL023C PET130 Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S06e01838g	similar to uniprot|Q3E772 Saccharomyces cerevisiae YGR169C-A (ohnolog of YJR005C-A) Putative protein of unknown function
LALA0_S06e01860g	similar to uniprot|P53037 Saccharomyces cerevisiae YGR170W PSD2 Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
LALA0_S06e01882g	similar to uniprot|P46957 Saccharomyces cerevisiae YJR006W POL31 DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair
LALA0_S06e01904g	similar to uniprot|P22438 Saccharomyces cerevisiae YGR171C MSM1 Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
LALA0_S06e01926g	similar to uniprot|P53039 Saccharomyces cerevisiae YGR172C YIP1 Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4
LALA0_S06e01948g	highly similar to uniprot|P53295 Saccharomyces cerevisiae YGR173W RBG2 Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein
LALA0_S06e01992g	highly similar to uniprot|Q07748 Saccharomyces cerevisiae YDL244W THI13 Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
LALA0_S06e02014g	similar to uniprot|C5DCG1 Lachancea thermotolerans KLTH0B02772g hypothetical protein
LALA0_S06e02036g	highly similar to uniprot|Q07915 Saccharomyces cerevisiae YLR009W RLP24 Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
LALA0_S06e02058g	similar to uniprot|Q07914 Saccharomyces cerevisiae YLR008C PAM18 Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p
LALA0_S06e02080g	weakly similar to uniprot|Q07913 Saccharomyces cerevisiae YLR007W NSE1 Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes
LALA0_S06e02102g	weakly similar to uniprot|Q07084 Saccharomyces cerevisiae YLR006C SSK1 Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
LALA0_S06e02124g	similar to uniprot|P27351 Saccharomyces cerevisiae YJR005W APL1 Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex
LALA0_S06e02146g	similar to uniprot|Q07897 Saccharomyces cerevisiae YLR003C CMS1 Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viable
LALA0_S06e02168g	highly similar to uniprot|Q07904 Saccharomyces cerevisiae YLR004C THI73 Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
LALA0_S06e02190g	similar to uniprot|C5DCG6 Lachancea thermotolerans KLTH0B02904g hypothetical protein
LALA0_S06e02212g	highly similar to uniprot|Q04673 Saccharomyces cerevisiae YLR005W SSL1 Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p
LALA0_S06e02234g	highly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake
LALA0_S06e02278g	some similarities with uniprot|P20840 Saccharomyces cerevisiae YJR004C SAG1 Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
LALA0_S06e02300g	weakly similar to uniprot|P47084 Saccharomyces cerevisiae YJR003C Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis
LALA0_S06e02322g	similar to uniprot|C5DG07 Lachancea thermotolerans KLTH0D01452g hypothetical protein
LALA0_S06e02344g	similar to uniprot|Q92280 Saccharomyces cerevisiae YLR002C NOC3 Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
LALA0_S06e02366g	similar to uniprot|P47083 Saccharomyces cerevisiae YJR002W MPP10 Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
LALA0_S06e02388g	similar to uniprot|P47082 Saccharomyces cerevisiae YJR001W AVT1 Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
LALA0_S06e02410g	some similarities with uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
LALA0_S06e02432g	similar to uniprot|Q07895 Saccharomyces cerevisiae YLR001C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated
LALA0_S06e02542g	highly similar to uniprot|P54861 Saccharomyces cerevisiae YLL001W DNM1 Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
LALA0_S06e02564g	similar to uniprot|Q07794 Saccharomyces cerevisiae YLL002W RTT109 Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p
LALA0_S06e02586g	highly similar to uniprot|P38624 Saccharomyces cerevisiae YJL001W PRE3 Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
LALA0_S06e02608g	weakly similar to uniprot|Q12369 Saccharomyces cerevisiae YLL003W SFI1 Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C
LALA0_S06e02630g	similar to uniprot|P41543 Saccharomyces cerevisiae YJL002C OST1 Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
LALA0_S06e02652g	similar to uniprot|P54790 Saccharomyces cerevisiae YLL004W ORC3 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
LALA0_S06e02674g	highly similar to uniprot|P47081 Saccharomyces cerevisiae YJL003W COX16 Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase
LALA0_S06e02696g	similar to uniprot|P41800 Saccharomyces cerevisiae YLL006W MMM1 ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
LALA0_S06e02718g	weakly similar to uniprot|Q07799 Saccharomyces cerevisiae YLL007C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene
LALA0_S06e02740g	highly similar to uniprot|P32892 Saccharomyces cerevisiae YLL008W DRS1 Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
LALA0_S06e02762g	highly similar to uniprot|P41544 Saccharomyces cerevisiae YJL004C SYS1 Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
LALA0_S06e02784g	similar to uniprot|P08678 Saccharomyces cerevisiae YJL005W CYR1 Adenylate cyclase, required for cAMPproduction and cAMP-dependent protein kinase signaling;the cAMP pathway controls a variety of cellular processes,including metabolism, cell cycle, stress response,stationary phase, and sporulation
LALA0_S06e02806g	similar to uniprot|Q12287 Saccharomyces cerevisiae YLL009C COX17 Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
LALA0_S06e02828g	highly similar to uniprot|Q07938 Saccharomyces cerevisiae YLR017W MEU1 Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
LALA0_S06e02850g	weakly similar to uniprot|Q7LGY6 Saccharomyces cerevisiae YLR018C POM34 Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex
LALA0_S06e02872g	similar to uniprot|Q07949 Saccharomyces cerevisiae YLR019W (ohnolog of YLL010C) PSR2 Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
LALA0_S06e02894g	highly similar to uniprot|P33750 Saccharomyces cerevisiae YLL011W SOF1 Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
LALA0_S06e02916g	similar to uniprot|Q07950 Saccharomyces cerevisiae YLR020C (ohnolog of YLL012W) YEH2 Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
LALA0_S06e02938g	similar to uniprot|Q07951 Saccharomyces cerevisiae YLR021W IRC25 Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
LALA0_S06e02960g	highly similar to uniprot|Q07953 Saccharomyces cerevisiae YLR022C SDO1 Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes
LALA0_S06e02982g	weakly similar to uniprot|Q07959 Saccharomyces cerevisiae YLR023C IZH3 Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
LALA0_S06e03004g	weakly similar to uniprot|P25339 Saccharomyces cerevisiae YGL014W PUF4 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors
LALA0_S06e03026g	similar to uniprot|Q12431 Saccharomyces cerevisiae YLL014W EMC6 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response
LALA0_S06e03048g	highly similar to uniprot|P48362 Saccharomyces cerevisiae YGR187C HGH1 Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)
LALA0_S06e03070g	similar to uniprot|P41895 Saccharomyces cerevisiae YGR186W TFG1 TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74
LALA0_S06e03092g	highly similar to uniprot|P36421 Saccharomyces cerevisiae YGR185C TYS1 Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies
LALA0_S06e03114g	similar to uniprot|Q07963 Saccharomyces cerevisiae YLR024C UBR2 Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex
LALA0_S06e03136g	similar to uniprot|P19812 Saccharomyces cerevisiae YGR184C UBR1 E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)
LALA0_S06e03158g	similar to uniprot|P22289 Saccharomyces cerevisiae YGR183C QCR9 Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
LALA0_S06e03180g	highly similar to uniprot|P53299 Saccharomyces cerevisiae YGR181W TIM13 Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
LALA0_S06e03224g	highly similar to uniprot|P47064 Saccharomyces cerevisiae YJL024C APS3 Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function
LALA0_S06e03246g	similar to uniprot|P37267 Saccharomyces cerevisiae YGR174C CBP4 Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex
LALA0_S06e03268g	highly similar to uniprot|P32476 Saccharomyces cerevisiae YGR175C ERG1 Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
LALA0_S06e03290g	similar to uniprot|G8ZZ34 Torulaspora delbrueckii TDEL_0H00190 hypothetical protein
LALA0_S06e03312g	similar to uniprot|P40353 Saccharomyces cerevisiae YOR377W ATF1 Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation
LALA0_S06e03334g	similar to uniprot|P40992 Saccharomyces cerevisiae YJL025W RRN7 Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
LALA0_S06e03356g	similar to uniprot|P53297 Saccharomyces cerevisiae YGR178C PBP1 Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation
LALA0_S06e03378g	weakly similar to uniprot|P53298 Saccharomyces cerevisiae YGR179C OKP1 Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
LALA0_S06e03400g	highly similar to uniprot|P32318 Saccharomyces cerevisiae YGR144W THI4 Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents
LALA0_S06e03422g	some similarities with uniprot|G8ZZ34 Torulaspora delbrueckii TDEL_0H00190 hypothetical protein
LALA0_S06e03444g	highly similar to uniprot|P09938 Saccharomyces cerevisiae YJL026W (ohnolog of YGR180C) RNR2 Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
LALA0_S06e03488g	highly similar to uniprot|P36010 Saccharomyces cerevisiae YKL067W YNK1 Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate
LALA0_S06e03510g	some similarities with uniprot|P07249 Saccharomyces cerevisiae YMR042W ARG80 Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
LALA0_S06e03532g	similar to uniprot|Q04213 Saccharomyces cerevisiae YMR044W IOC4 Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif
LALA0_S06e03554g	similar to uniprot|Q02630 Saccharomyces cerevisiae YMR047C (ohnolog of YKL068W) NUP116 Subunit of the Nup82 subcomplex of the nuclear pore complex; localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p
LALA0_S06e03576g	hypothetical protein
LALA0_S06e03598g	weakly similar to uniprot|Q04659 Saccharomyces cerevisiae YMR048W CSM3 Replication fork associated factor, required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis
LALA0_S06e03620g	highly similar to uniprot|Q04660 Saccharomyces cerevisiae YMR049C ERB1 Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1
LALA0_S06e03664g	similar to uniprot|P36088 Saccharomyces cerevisiae YKL069W Methionine-R-sulfoxide reductase, reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress
LALA0_S06e03708g	similar to uniprot|P46671 Saccharomyces cerevisiae YMR052W FAR3 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum
LALA0_S06e03730g	weakly similar to uniprot|P46679 Saccharomyces cerevisiae YMR053C (ohnolog of YKL072W) STB2 Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
LALA0_S06e03752g	similar to uniprot|P37296 Saccharomyces cerevisiae YMR054W STV1 Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole
LALA0_S06e03774g	similar to uniprot|P36016 Saccharomyces cerevisiae YKL073W LHS1 Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway
LALA0_S06e03796g	weakly similar to uniprot|P36084 Saccharomyces cerevisiae YKL074C MUD2 Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
LALA0_S06e03818g	highly similar to uniprot|P26448 Saccharomyces cerevisiae YMR055C BUB2 Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
LALA0_S06e03840g	some similarities with uniprot|C5DCQ8 Lachancea thermotolerans KLTH0B05060g hypothetical protein
LALA0_S06e03862g	similar to uniprot|P38993 Saccharomyces cerevisiae YMR058W FET3 Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases
LALA0_S06e03884g	similar to uniprot|P36083 Saccharomyces cerevisiae YKL075C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
LALA0_S06e03906g	similar to uniprot|P36081 Saccharomyces cerevisiae YKL077W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
LALA0_S06e03928g	similar to uniprot|Q04675 Saccharomyces cerevisiae YMR059W SEN15 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
LALA0_S06e03950g	similar to uniprot|P50110 Saccharomyces cerevisiae YMR060C SAM37 Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability
LALA0_S06e03972g	similar to uniprot|P25298 Saccharomyces cerevisiae YMR061W RNA14 Cleavage and polyadenylation factor I (CF I) component; involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
LALA0_S06e03994g	highly similar to uniprot|Q04728 Saccharomyces cerevisiae YMR062C ARG7 Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
LALA0_S06e04016g	similar to uniprot|P39932 Saccharomyces cerevisiae YDR536W STL1 Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
LALA0_S06e04038g	hypothetical protein
LALA0_S06e04060g	similar to uniprot|P48016 Saccharomyces cerevisiae YPR026W ATH1 Acid trehalase required for utilization of extracellular trehalose
LALA0_S06e04104g	similar to uniprot|Q12402 Saccharomyces cerevisiae YPR028W YOP1 Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes
LALA0_S06e04126g	similar to uniprot|Q12028 Saccharomyces cerevisiae YPR029C APL4 Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
LALA0_S06e04148g	similar to uniprot|P38167 Saccharomyces cerevisiae YBL101C (ohnolog of YPR030W) ECM21 Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements
LALA0_S06e04170g	highly similar to uniprot|P38166 Saccharomyces cerevisiae YBL102W SFT2 Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
LALA0_S06e04192g	weakly similar to uniprot|P38165 Saccharomyces cerevisiae YBL103C RTG3 Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
LALA0_S06e04214g	similar to uniprot|Q12311 Saccharomyces cerevisiae YPR031W NTO1 Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3
LALA0_S06e04236g	similar to uniprot|P38164 Saccharomyces cerevisiae YBL104C SEA4 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites
LALA0_S06e04258g	similar to uniprot|P24583 Saccharomyces cerevisiae YBL105C PKC1 Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
LALA0_S06e04280g	similar to uniprot|P38163 Saccharomyces cerevisiae YBL106C (ohnolog of YPR032W) SRO77 Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p
LALA0_S06e04302g	similar to uniprot|P38162 Saccharomyces cerevisiae YBL107C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene
LALA0_S06e04324g	similar to uniprot|P47125 Saccharomyces cerevisiae YJR078W BNA2 Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
LALA0_S06e04346g	highly similar to uniprot|P07263 Saccharomyces cerevisiae YPR033C HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
LALA0_S06e04368g	weakly similar to uniprot|P47127 Saccharomyces cerevisiae YJR080C AIM24 Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss
LALA0_S06e04390g	similar to uniprot|P47128 Saccharomyces cerevisiae YJR082C EAF6 Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
LALA0_S06e04412g	similar to uniprot|Q12406 Saccharomyces cerevisiae YPR034W ARP7 Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
LALA0_S06e04434g	similar to uniprot|C5DDX4 Lachancea thermotolerans KLTH0C04532g hypothetical protein
LALA0_S06e04456g	similar to uniprot|P38241 Saccharomyces cerevisiae YBR065C ECM2 Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
LALA0_S06e04478g	similar to uniprot|P38239 Saccharomyces cerevisiae YBR062C Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.
LALA0_S06e04500g	similar to uniprot|Q03201 Saccharomyces cerevisiae YDR041W RSM10 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
LALA0_S06e04522g	highly similar to uniprot|P38238 Saccharomyces cerevisiae YBR061C TRM7 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
LALA0_S06e04544g	highly similar to uniprot|P15180 Saccharomyces cerevisiae YDR037W KRS1 Lysyl-tRNA synthetase
LALA0_S06e04566g	similar to uniprot|Q7LHX4 Saccharomyces cerevisiae YDR051C DET1 Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
LALA0_S06e04588g	highly similar to uniprot|P00942 Saccharomyces cerevisiae YDR050C TPI1 Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
LALA0_S06e04610g	similar to uniprot|P38242 Saccharomyces cerevisiae YBR070C ALG14 Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
LALA0_S06e04632g	weakly similar to uniprot|P38243 Saccharomyces cerevisiae YBR071W Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking
LALA0_S06e04654g	similar to uniprot|P38086 Saccharomyces cerevisiae YBR073W RDH54 DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference
LALA0_S06e04676g	similar to uniprot|Q66RH0 Saccharomyces cerevisiae YDR049W VMS1 Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
LALA0_S06e04698g	highly similar to uniprot|P32347 Saccharomyces cerevisiae YDR047W HEM12 Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
LALA0_S06e04720g	similar to uniprot|P38244 Saccharomyces cerevisiae YBR074W Putative metalloprotease
LALA0_S06e04742g	some similarities with uniprot|P14922 Saccharomyces cerevisiae YBR112C CYC8 General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]
LALA0_S06e04764g	similar to uniprot|P53753 Saccharomyces cerevisiae YNR067C DSE4 Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
LALA0_S06e04786g	weakly similar to uniprot|Q12145 Saccharomyces cerevisiae YPR013C Putative zinc finger protein; YPR013C is not an essential gene
LALA0_S06e04808g	similar to uniprot|P32325 Saccharomyces cerevisiae YDR052C DBF4 Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated
LALA0_S06e04830g	similar to uniprot|P38247 Saccharomyces cerevisiae YBR077C SLM4 Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
LALA0_S06e04852g	highly similar to uniprot|P14682 Saccharomyces cerevisiae YDR054C CDC34 Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation
LALA0_S06e04874g	weakly similar to uniprot|P22580 Saccharomyces cerevisiae YDR242W AMD2 Putative amidase
LALA0_S06e04896g	similar to uniprot|Q04814 Saccharomyces cerevisiae YMR252C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene
LALA0_S06e04918g	similar to uniprot|Q04835 Saccharomyces cerevisiae YMR253C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene
LALA0_S06e04940g	weakly similar to uniprot|Q04839 Saccharomyces cerevisiae YMR255W GFD1 Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
LALA0_S06e04962g	similar to uniprot|Q05667 Saccharomyces cerevisiae YOL053W AIM39 Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S06e04984g	highly similar to uniprot|P10174 Saccharomyces cerevisiae YMR256C COX7 Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
LALA0_S06e05006g	weakly similar to uniprot|Q12161 Saccharomyces cerevisiae YOL054W PSH1 E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
LALA0_S06e05028g	weakly similar to uniprot|P08468 Saccharomyces cerevisiae YMR257C PET111 Mitochondrial translationalactivator specific for the COX2 mRNA; located in themitochondrial inner membrane
LALA0_S06e05050g	similar to uniprot|Q04847 Saccharomyces cerevisiae YMR258C ROY1 GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
LALA0_S06e05094g	similar to uniprot|Q03496 Saccharomyces cerevisiae YMR259C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene
LALA0_S06e05116g	highly similar to uniprot|C5DLS2 Lachancea thermotolerans KLTH0G03014g hypothetical protein
LALA0_S06e05138g	highly similar to uniprot|P38912 Saccharomyces cerevisiae YMR260C TIF11 Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
LALA0_S06e05160g	similar to uniprot|P38426 Saccharomyces cerevisiae YMR261C (ohnolog of YML100W) TPS3 Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
LALA0_S06e05182g	similar to uniprot|P38430 Saccharomyces cerevisiae YMR262W Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
LALA0_S06e05204g	similar to uniprot|P38429 Saccharomyces cerevisiae YMR263W SAP30 Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
LALA0_S06e05226g	similar to uniprot|Q04201 Saccharomyces cerevisiae YML101C (ohnolog of YMR264W) CUE4 Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
LALA0_S06e05248g	similar to uniprot|Q04199 Saccharomyces cerevisiae YML102W CAC2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
LALA0_S06e05270g	weakly similar to uniprot|Q03508 Saccharomyces cerevisiae YMR265C Putative protein of unknown function
LALA0_S06e05292g	similar to uniprot|Q03516 Saccharomyces cerevisiae YMR266W RSN1 Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane
LALA0_S06e05314g	similar to uniprot|P28239 Saccharomyces cerevisiae YMR267W PPA2 Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
LALA0_S06e05336g	similar to uniprot|P52593 Saccharomyces cerevisiae YML103C NUP188 Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
LALA0_S06e05358g	similar to uniprot|P49960 Saccharomyces cerevisiae YMR268C PRP24 Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
LALA0_S06e05380g	similar to uniprot|Q03525 Saccharomyces cerevisiae YMR269W TMA23 Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan
LALA0_S06e05402g	similar to uniprot|Q01846 Saccharomyces cerevisiae YML104C MDM1 Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
LALA0_S06e05424g	similar to uniprot|P53437 Saccharomyces cerevisiae YMR270C RRN9 Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
LALA0_S06e05446g	similar to uniprot|P29478 Saccharomyces cerevisiae YML105C SEC65 Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19
LALA0_S06e05468g	highly similar to uniprot|P30402 Saccharomyces cerevisiae YMR271C (ohnolog of YML106W) URA10 Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
LALA0_S06e05490g	weakly similar to uniprot|Q03760 Saccharomyces cerevisiae YML107C PML39 Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes
LALA0_S06e05512g	highly similar to uniprot|Q03529 Saccharomyces cerevisiae YMR272C SCS7 Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
LALA0_S06e05556g	similar to uniprot|Q04048 Saccharomyces cerevisiae YDR416W SYF1 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
LALA0_S06e05578g	highly similar to uniprot|P32610 Saccharomyces cerevisiae YEL051W VMA8 Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
LALA0_S06e05600g	similar to uniprot|Q04033 Saccharomyces cerevisiae YDR415C Putative protein of unknown function
LALA0_S06e05622g	highly similar to uniprot|P32611 Saccharomyces cerevisiae YEL050C RML2 Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
LALA0_S06e05644g	similar to uniprot|P05316 Saccharomyces cerevisiae YBR021W FUR4 Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
LALA0_S06e05666g	weakly similar to uniprot|P16151 Saccharomyces cerevisiae YDR414C ERD1 Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
LALA0_S06e05688g	similar to uniprot|Q04031 Saccharomyces cerevisiae YDR412W RRP17 Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5' end processing of pre-60S ribosomal RNA
LALA0_S06e05710g	weakly similar to uniprot|Q7LIJ5 Saccharomyces cerevisiae YDR411C DFM1 Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
LALA0_S06e05732g	similar to uniprot|P32796 Saccharomyces cerevisiae YML042W CAT2 Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
LALA0_S06e05776g	similar to uniprot|Q03433 Saccharomyces cerevisiae YML041C VPS71 Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
LALA0_S06e05798g	similar to uniprot|P32584 Saccharomyces cerevisiae YDR410C STE14 Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane
LALA0_S06e05820g	weakly similar to uniprot|Q04195 Saccharomyces cerevisiae YDR409W (ohnolog of YOR156C) SIZ1 SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
LALA0_S06e05842g	highly similar to uniprot|P04161 Saccharomyces cerevisiae YDR408C ADE8 Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
LALA0_S06e05864g	highly similar to uniprot|P25043 Saccharomyces cerevisiae YOR157C PUP1 Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
LALA0_S06e05886g	similar to uniprot|Q04183 Saccharomyces cerevisiae YDR407C TRS120 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
LALA0_S06e05908g	similar to uniprot|P17558 Saccharomyces cerevisiae YOR158W PET123 Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
LALA0_S06e05930g	similar to uniprot|Q12330 Saccharomyces cerevisiae YOR159C SME1 Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
LALA0_S06e05952g	similar to uniprot|Q99189 Saccharomyces cerevisiae YOR160W MTR10 Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs
LALA0_S06e05974g	highly similar to uniprot|Q12412 Saccharomyces cerevisiae YOR161C PNS1 Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport
LALA0_S06e05996g	similar to uniprot|Q99312 Saccharomyces cerevisiae YOR155C ISN1 Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
LALA0_S06e06018g	similar to uniprot|C5DLS2 Lachancea thermotolerans KLTH0G03014g hypothetical protein
LALA0_S06e06040g	similar to uniprot|P32387 Saccharomyces cerevisiae YDR405W MRP20 Mitochondrial ribosomal protein of the large subunit
LALA0_S06e06062g	highly similar to uniprot|P08518 Saccharomyces cerevisiae YOR151C RPB2 RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
LALA0_S06e06084g	highly similar to uniprot|Q12487 Saccharomyces cerevisiae YOR150W MRPL23 Mitochondrial ribosomal protein of the large subunit
LALA0_S06e06106g	highly similar to uniprot|P34087 Saccharomyces cerevisiae YDR404C RPB7 RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
LALA0_S06e06128g	similar to uniprot|P21623 Saccharomyces cerevisiae YDR403W DIT1 Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure
LALA0_S06e06150g	similar to uniprot|P21595 Saccharomyces cerevisiae YDR402C DIT2 N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s
LALA0_S06e06172g	similar to uniprot|Q04179 Saccharomyces cerevisiae YDR400W URH1 Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
LALA0_S06e06194g	similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
LALA0_S06e06216g	highly similar to uniprot|Q04178 Saccharomyces cerevisiae YDR399W HPT1 Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
LALA0_S06e06238g	similar to uniprot|Q04177 Saccharomyces cerevisiae YDR398W UTP5 Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
LALA0_S06e06260g	similar to uniprot|Q04176 Saccharomyces cerevisiae YDR397C NCB2 Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
LALA0_S06e06282g	similar to uniprot|Q04175 Saccharomyces cerevisiae YDR395W SXM1 Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
LALA0_S06e06304g	similar to uniprot|Q04174 Saccharomyces cerevisiae YOR149C SMP3 Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
LALA0_S06e06326g	highly similar to uniprot|P33298 Saccharomyces cerevisiae YDR394W RPT3 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
LALA0_S06e06348g	similar to uniprot|Q04172 Saccharomyces cerevisiae YDR393W SHE9 Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex
LALA0_S06e06370g	weakly similar to uniprot|Q02521 Saccharomyces cerevisiae YOR148C SPP2 Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
LALA0_S06e06392g	similar to uniprot|Q12171 Saccharomyces cerevisiae YOR147W MDM32 Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
LALA0_S06e06414g	highly similar to uniprot|Q7LHP7 Saccharomyces cerevisiae YOR145C PNO1 Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain
LALA0_S06e06436g	weakly similar to uniprot|Q12050 Saccharomyces cerevisiae YOR144C ELG1 Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis
LALA0_S06e06458g	highly similar to uniprot|P06844 Saccharomyces cerevisiae YDR392W SPT3 Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
LALA0_S06e06480g	similar to uniprot|P35202 Saccharomyces cerevisiae YOR143C THI80 Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
LALA0_S06e06502g	hypothetical protein
LALA0_S06e06546g	highly similar to uniprot|P53598 Saccharomyces cerevisiae YOR142W LSC1 Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated
LALA0_S06e06568g	similar to uniprot|P53280 Saccharomyces cerevisiae YGR134W CAF130 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
LALA0_S06e06590g	similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
LALA0_S06e06612g	weakly similar to uniprot|Q06525 Saccharomyces cerevisiae YPR152C URN1 Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase
LALA0_S06e06634g	highly similar to uniprot|P23638 Saccharomyces cerevisiae YGR135W PRE9 Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform
LALA0_S06e06656g	similar to uniprot|Q06HN0 Saccharomyces cerevisiae YPR153W Putative protein of unknown function
LALA0_S06e06678g	similar to uniprot|P53281 Saccharomyces cerevisiae YGR136W (ohnolog of YPR154W) LSB1 Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
LALA0_S06e06700g	similar to uniprot|Q12374 Saccharomyces cerevisiae YPR155C NCA2 Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p
LALA0_S06e06722g	hypothetical protein
LALA0_S06e06744g	highly similar to uniprot|P53283 Saccharomyces cerevisiae YGR138C (ohnolog of YPR156C) TPO2 Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
LALA0_S06e06766g	similar to uniprot|P32504 Saccharomyces cerevisiae YGR140W CBF2 Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
LALA0_S06e06788g	similar to uniprot|P53285 Saccharomyces cerevisiae YGR141W (ohnolog of YPR157W) VPS62 Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins
LALA0_S06e06810g	similar to uniprot|P53286 Saccharomyces cerevisiae YGR142W (ohnolog of YPR158W) BTN2 v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
LALA0_S06e06854g	similar to uniprot|C5DLN5 Lachancea thermotolerans KLTH0G02156g hypothetical protein
LALA0_S06e06898g	similar to uniprot|P33336 Saccharomyces cerevisiae YGR143W (ohnolog of YPR159W) SKN1 Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
LALA0_S06e06964g	similar to uniprot|P53091 Saccharomyces cerevisiae YGL201C MCM6 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p
LALA0_S06e06986g	highly similar to uniprot|P06738 Saccharomyces cerevisiae YPR160W GPH1 Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
LALA0_S06e07008g	weakly similar to uniprot|P36035 Saccharomyces cerevisiae YKL217W JEN1 Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose
LALA0_S06e07030g	similar to uniprot|P53090 Saccharomyces cerevisiae YGL202W ARO8 Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
LALA0_S06e07052g	similar to uniprot|P09620 Saccharomyces cerevisiae YGL203C KEX1 Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
LALA0_S06e07074g	similar to uniprot|P08456 Saccharomyces cerevisiae YER026C CHO1 Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
LALA0_S06e07096g	similar to uniprot|P13711 Saccharomyces cerevisiae YGL205W POX1 Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
LALA0_S06e07118g	hypothetical protein
LALA0_S06e07140g	similar to uniprot|C5DCQ8 Lachancea thermotolerans KLTH0B05060g hypothetical protein
LALA0_S06e07162g	highly similar to uniprot|P22137 Saccharomyces cerevisiae YGL206C CHC1 Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function
LALA0_S06e07184g	highly similar to uniprot|P32558 Saccharomyces cerevisiae YGL207W SPT16 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases
LALA0_S06e07206g	similar to uniprot|P34164 Saccharomyces cerevisiae YGL208W (ohnolog of YER027C) SIP2 One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
LALA0_S06e07228g	some similarities with uniprot|P53035 Saccharomyces cerevisiae YGL209W (ohnolog of YER028C) MIG2 Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
LALA0_S06e07250g	similar to Lachancea thermotolerans KLTH0E00308g hypothetical protein
LALA0_S06e07272g	similar to uniprot|P40018 Saccharomyces cerevisiae YER029C SMB1 Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'
LALA0_S06e07294g	similar to uniprot|P40019 Saccharomyces cerevisiae YER030W CHZ1 Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif
LALA0_S06e07316g	highly similar to uniprot|P51996 Saccharomyces cerevisiae YGL210W (ohnolog of YER031C) YPT32 Rab family GTPase, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
LALA0_S06e07338g	weakly similar to uniprot|P40020 Saccharomyces cerevisiae YER032W FIR1 Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
LALA0_S06e07360g	weakly similar to uniprot|P40021 Saccharomyces cerevisiae YER033C ZRG8 Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
LALA0_S06e07382g	highly similar to uniprot|P53088 Saccharomyces cerevisiae YGL211W NCS6 Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
LALA0_S06e07404g	weakly similar to uniprot|P32912 Saccharomyces cerevisiae YGL212W VAM7 Vacuolar SNARE protein that functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog
LALA0_S06e07426g	similar to uniprot|Q02793 Saccharomyces cerevisiae YGL213C SKI8 Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype
LALA0_S06e07448g	similar to uniprot|P35190 Saccharomyces cerevisiae YGL215W CLG1 Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2
LALA0_S06e07470g	similar to uniprot|P53086 Saccharomyces cerevisiae YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning
LALA0_S06e07492g	similar to uniprot|P53083 Saccharomyces cerevisiae YGL219C MDM34 Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
LALA0_S06e07514g	similar to uniprot|P53082 Saccharomyces cerevisiae YGL220W FRA2 Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
LALA0_S06e07536g	similar to uniprot|P53081 Saccharomyces cerevisiae YGL221C NIF3 Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S06e07558g	similar to uniprot|P40022 Saccharomyces cerevisiae YER034W Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage
LALA0_S06e07580g	some similarities with uniprot|P53080 Saccharomyces cerevisiae YGL222C (ohnolog of YER035W) EDC1 RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress
LALA0_S06e07602g	highly similar to uniprot|P40024 Saccharomyces cerevisiae YER036C ARB1 ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
LALA0_S06e07624g	highly similar to uniprot|C5E1W6 Lachancea thermotolerans KLTH0H00198g hypothetical protein
LALA0_S06e07646g	similar to Lachancea thermotolerans KLTH0G01408g hypothetical protein
LALA0_S06e07668g	weakly similar to Lachancea thermotolerans KLTH0G01408g hypothetical protein
LALA0_S06e07690g	similar to uniprot|P53078 Saccharomyces cerevisiae YGL224C (ohnolog of YER037W) SDT1 Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
LALA0_S06e07712g	weakly similar to uniprot|P40026 Saccharomyces cerevisiae YER038C KRE29 Essential subunit of the Mms21-Smc5-Smc6 complex, required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
LALA0_S06e07734g	highly similar to uniprot|P40107 Saccharomyces cerevisiae YGL225W (ohnolog of YER039C) VRG4 Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
LALA0_S06e07756g	weakly similar to uniprot|P18494 Saccharomyces cerevisiae YER040W GLN3 Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source
LALA0_S06e07778g	weakly similar to uniprot|P40028 Saccharomyces cerevisiae YER041W YEN1 Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
LALA0_S06e07800g	highly similar to uniprot|P40029 Saccharomyces cerevisiae YER042W MXR1 Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan
LALA0_S06e07822g	weakly similar to uniprot|P53077 Saccharomyces cerevisiae YGL226W MTC3 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1
LALA0_S06e07844g	similar to uniprot|Q92316 Saccharomyces cerevisiae YGL226C-A OST5 Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
LALA0_S06e07866g	similar to uniprot|P53076 Saccharomyces cerevisiae YGL227W VID30 Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); binds FBPase; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm
LALA0_S06e07888g	highly similar to uniprot|P39954 Saccharomyces cerevisiae YER043C SAH1 S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
LALA0_S06e07910g	weakly similar to uniprot|P53075 Saccharomyces cerevisiae YGL228W (ohnolog of YFR039C) SHE10 Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest
LALA0_S06e07932g	similar to uniprot|P53036 Saccharomyces cerevisiae YGL229C (ohnolog of YFR040W) SAP4 Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
LALA0_S06e07954g	similar to uniprot|P43613 Saccharomyces cerevisiae YFR041C ERJ5 Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
LALA0_S06e07976g	similar to uniprot|P43614 Saccharomyces cerevisiae YFR042W KEG1 Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
LALA0_S06e07998g	weakly similar to uniprot|P43615 Saccharomyces cerevisiae YFR043C IRC6 Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
LALA0_S06e08020g	hypothetical protein
LALA0_S06e08042g	similar to uniprot|P53073 Saccharomyces cerevisiae YGL231C EMC4 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis
LALA0_S06e08064g	similar to uniprot|P53072 Saccharomyces cerevisiae YGL232W TAN1 Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA
LALA0_S06e08086g	similar to uniprot|P22224 Saccharomyces cerevisiae YGL233W SEC15 Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles
LALA0_S06e08108g	similar to uniprot|P43616 Saccharomyces cerevisiae YFR044C DUG1 Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
LALA0_S06e08130g	similar to uniprot|P43617 Saccharomyces cerevisiae YFR045W Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
LALA0_S06e08152g	similar to uniprot|P07244 Saccharomyces cerevisiae YGL234W ADE5,7 Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
LALA0_S06e08174g	similar to uniprot|P53070 Saccharomyces cerevisiae YGL236C MTO1 Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
LALA0_S06e08196g	hypothetical protein
LALA0_S06e08218g	weakly similar to uniprot|P06774 Saccharomyces cerevisiae YGL237C HAP2 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
LALA0_S06e08240g	highly similar to uniprot|P33307 Saccharomyces cerevisiae YGL238W CSE1 Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
LALA0_S06e08262g	similar to uniprot|P53068 Saccharomyces cerevisiae YGL240W DOC1 Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain
LALA0_S06e08284g	highly similar to uniprot|P43619 Saccharomyces cerevisiae YFR047C BNA6 Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
LALA0_S06e08306g	similar to uniprot|P53067 Saccharomyces cerevisiae YGL241W KAP114 Karyopherin, responsible for nuclear import of Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear
LALA0_S06e08328g	similar to uniprot|P53066 Saccharomyces cerevisiae YGL242C Putative protein of unknown function; deletion mutant is viable
LALA0_S06e08350g	similar to uniprot|P53065 Saccharomyces cerevisiae YGL243W TAD1 tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala
LALA0_S06e08372g	similar to uniprot|P53064 Saccharomyces cerevisiae YGL244W RTF1 Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
LALA0_S06e08394g	similar to uniprot|P43620 Saccharomyces cerevisiae YFR048W RMD8 Cytosolic protein required for sporulation
LALA0_S06e08416g	highly similar to uniprot|P46655 Saccharomyces cerevisiae YGL245W GUS1 Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm
LALA0_S06e08438g	similar to uniprot|P53063 Saccharomyces cerevisiae YGL246C RAI1 Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
LALA0_S06e08460g	weakly similar to uniprot|P53062 Saccharomyces cerevisiae YGL247W BRR6 Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
LALA0_S06e08482g	similar to uniprot|P19955 Saccharomyces cerevisiae YFR049W YMR31 Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
LALA0_S06e08504g	similar to uniprot|P22434 Saccharomyces cerevisiae YGL248W PDE1 Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
LALA0_S06e08526g	highly similar to uniprot|P30657 Saccharomyces cerevisiae YFR050C PRE4 Beta 7 subunit of the 20S proteasome
LALA0_S06e08548g	similar to uniprot|P43621 Saccharomyces cerevisiae YFR051C RET2 Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
LALA0_S06e08570g	some similarities with uniprot|P53060 Saccharomyces cerevisiae YGL250W RMR1 Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus
LALA0_S06e08592g	highly similar to uniprot|P32608 Saccharomyces cerevisiae YGL252C RTG2 Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
LALA0_S06e08614g	similar to uniprot|P32496 Saccharomyces cerevisiae YFR052W RPN12 Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
LALA0_S06e08636g	highly similar to uniprot|P04807 Saccharomyces cerevisiae YGL253W (ohnolog of YFR053C) HXK2 Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
LALA0_S06e08658g	some similarities with uniprot|B5FV78 Kluyveromyces lactis KLLA0D15576g hypothetical protein
LALA0_S07e00100g	similar to uniprot|P32505 Saccharomyces cerevisiae YGL122C NAB2 Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p
LALA0_S07e00122g	highly similar to uniprot|P25443 Saccharomyces cerevisiae YGL123W RPS2 Protein component of the small (40S) subunit, essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p
LALA0_S07e00144g	weakly similar to uniprot|P38325 Saccharomyces cerevisiae YBR230C OM14 Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
LALA0_S07e00166g	similar to uniprot|P53129 Saccharomyces cerevisiae YGL124C MON1 Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate
LALA0_S07e00188g	weakly similar to uniprot|P40209 Saccharomyces cerevisiae YMR136W GAT2 Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
LALA0_S07e00210g	similar to uniprot|P38138 Saccharomyces cerevisiae YBR229C ROT2 Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
LALA0_S07e00232g	similar to uniprot|P38324 Saccharomyces cerevisiae YBR228W SLX1 Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
LALA0_S07e00254g	similar to uniprot|P38323 Saccharomyces cerevisiae YBR227C MCX1 Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins
LALA0_S07e00276g	weakly similar to uniprot|P38321 Saccharomyces cerevisiae YBR225W Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components
LALA0_S07e00298g	highly similar to uniprot|P53128 Saccharomyces cerevisiae YGL125W MET13 Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
LALA0_S07e00320g	similar to uniprot|P38319 Saccharomyces cerevisiae YBR223C TDP1 Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI
LALA0_S07e00342g	highly similar to uniprot|P38137 Saccharomyces cerevisiae YBR222C PCS60 Peroxisomal protein that bindsAMP and mRNA, localizes to both the peroxisomal peripheralmembrane and matrix, expression is highly inducible byoleic acid, similar to E. coli long chain acyl-CoAsynthetase
LALA0_S07e00364g	highly similar to uniprot|P32473 Saccharomyces cerevisiae YBR221C PDB1 E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria
LALA0_S07e00386g	similar to uniprot|P38318 Saccharomyces cerevisiae YBR220C Putative protein of unknown function; YBR220C is not an essential gene
LALA0_S07e00408g	similar to uniprot|P53012 Saccharomyces cerevisiae YGL126W SCS3 Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol
LALA0_S07e00430g	similar to uniprot|P38633 Saccharomyces cerevisiae YGL127C SOH1 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits
LALA0_S07e00452g	highly similar to uniprot|P11154 Saccharomyces cerevisiae YGL062W (ohnolog of YBR218C) PYC1 Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
LALA0_S07e00474g	weakly similar to uniprot|P53168 Saccharomyces cerevisiae YGL061C DUO1 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
LALA0_S07e00496g	similar to uniprot|P38316 Saccharomyces cerevisiae YBR217W ATG12 Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
LALA0_S07e00518g	similar to uniprot|P53169 Saccharomyces cerevisiae YGL060W (ohnolog of YBR216C) YBP2 Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p
LALA0_S07e00540g	weakly similar to uniprot|Q01448 Saccharomyces cerevisiae YBR215W HPC2 Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes
LALA0_S07e00562g	similar to uniprot|P53170 Saccharomyces cerevisiae YGL059W PKP2 Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p
LALA0_S07e00584g	highly similar to uniprot|P06104 Saccharomyces cerevisiae YGL058W RAD6 Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p
LALA0_S07e00606g	weakly similar to uniprot|P53171 Saccharomyces cerevisiae YGL057C GEP7 Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S07e00628g	similar to uniprot|P53172 Saccharomyces cerevisiae YGL056C (ohnolog of YBR214W) SDS23 One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding
LALA0_S07e00650g	similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
LALA0_S07e00672g	similar to uniprot|P38090 Saccharomyces cerevisiae YBR132C AGP2 High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
LALA0_S07e00694g	some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p
LALA0_S07e00716g	similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Delta(9) fatty acid desaturase, required formonounsaturated fatty acid synthesis and for normaldistribution of mitochondria
LALA0_S07e00738g	similar to uniprot|P15807 Saccharomyces cerevisiae YBR213W MET8 Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
LALA0_S07e00760g	weakly similar to uniprot|P32831 Saccharomyces cerevisiae YBR212W NGR1 RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase
LALA0_S07e00782g	weakly similar to uniprot|P38313 Saccharomyces cerevisiae YBR211C AME1 Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance
LALA0_S07e00804g	highly similar to uniprot|P53173 Saccharomyces cerevisiae YGL054C (ohnolog of YBR210W) ERV14 Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon
LALA0_S07e00848g	similar to uniprot|Q05905 Saccharomyces cerevisiae YLR301W HRI1 Protein of unknown function that interacts with Sec72p and Hrr25p
LALA0_S07e00870g	similar to uniprot|Q08562 Saccharomyces cerevisiae YOR191W ULS1 RING finger protein involved in proteolytic control of sumoylated substrates; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching
LALA0_S07e00892g	highly similar to uniprot|P32603 Saccharomyces cerevisiae YOR190W (ohnolog of YLR300W) SPR1 Sporulation-specific exo-1,3-beta-glucanase; contributes to ascosporethermoresistance
LALA0_S07e00914g	some similarities with uniprot|C5E2R1 Lachancea thermotolerans KLTH0H07018g hypothetical protein
LALA0_S07e00958g	weakly similar to Lachancea thermotolerans KLTH0H07150g hypothetical protein
LALA0_S07e00980g	similar to uniprot|P21339 Saccharomyces cerevisiae YOR188W MSB1 Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4
LALA0_S07e01002g	similar to uniprot|Q05902 Saccharomyces cerevisiae YLR299W ECM38 Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
LALA0_S07e01024g	highly similar to uniprot|P02992 Saccharomyces cerevisiae YOR187W TUF1 Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans
LALA0_S07e01046g	weakly similar to uniprot|Q05900 Saccharomyces cerevisiae YLR298C YHC1 Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
LALA0_S07e01068g	weakly similar to uniprot|P38960 Saccharomyces cerevisiae YDR082W STN1 Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping
LALA0_S07e01090g	similar to uniprot|C5E2W0 Lachancea thermotolerans KLTH0H08140g hypothetical protein
LALA0_S07e01112g	similar to uniprot|P32896 Saccharomyces cerevisiae YDR081C PDC2 Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes
LALA0_S07e01134g	similar to uniprot|P38959 Saccharomyces cerevisiae YDR080W VPS41 Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport
LALA0_S07e01156g	highly similar to uniprot|Q3E7C1 Saccharomyces cerevisiae YDR079C-A TFB5 Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1- S protein involved in DNA repair
LALA0_S07e01178g	similar to uniprot|P40094 Saccharomyces cerevisiae YER157W COG3 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
LALA0_S07e01200g	similar to uniprot|P53283 Saccharomyces cerevisiae YGR138C (ohnolog of YPR156C) TPO2 Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
LALA0_S07e01222g	highly similar to uniprot|P38958 Saccharomyces cerevisiae YDR079W PET100 Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
LALA0_S07e01244g	similar to uniprot|P40093 Saccharomyces cerevisiae YER156C Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1
LALA0_S07e01266g	similar to uniprot|P39960 Saccharomyces cerevisiae YER155C BEM2 Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
LALA0_S07e01288g	similar to uniprot|P39952 Saccharomyces cerevisiae YER154W OXA1 Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals
LALA0_S07e01310g	weakly similar to uniprot|P10355 Saccharomyces cerevisiae YER153C PET122 Mitochondrial translationalactivator specific for the COX3 mRNA, acts together withPet54p and Pet494p; located in the mitochondrial innermembrane
LALA0_S07e01332g	similar to uniprot|P10356 Saccharomyces cerevisiae YER152C Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene
LALA0_S07e01354g	some similarities with uniprot|P38957 Saccharomyces cerevisiae YDR078C SHU2 Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p
LALA0_S07e01376g	similar to uniprot|Q01477 Saccharomyces cerevisiae YER151C UBP3 Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity
LALA0_S07e01398g	weakly similar to uniprot|P40092 Saccharomyces cerevisiae YER150W (ohnolog of YDR077W) SPI1 GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
LALA0_S07e01420g	weakly similar to uniprot|P38953 Saccharomyces cerevisiae YDR076W RAD55 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
LALA0_S07e01442g	highly similar to uniprot|P32345 Saccharomyces cerevisiae YDR075W PPH3 Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
LALA0_S07e01464g	weakly similar to uniprot|Q70DD8 Saccharomyces cerevisiae YER149C PEA2 Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
LALA0_S07e01486g	highly similar to uniprot|P13393 Saccharomyces cerevisiae YER148W SPT15 TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
LALA0_S07e01508g	similar to uniprot|P40090 Saccharomyces cerevisiae YER147C SCC4 Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
LALA0_S07e01530g	similar to uniprot|P31688 Saccharomyces cerevisiae YDR074W TPS2 Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
LALA0_S07e01552g	some similarities with uniprot|P38956 Saccharomyces cerevisiae YDR073W SNF11 Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
LALA0_S07e01574g	similar to uniprot|P38954 Saccharomyces cerevisiae YDR072C IPT1 Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid;, can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
LALA0_S07e01596g	similar to uniprot|P40089 Saccharomyces cerevisiae YER146W LSM5 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
LALA0_S07e01618g	similar to uniprot|Q12447 Saccharomyces cerevisiae YDR071C PAA1 Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication
LALA0_S07e01640g	similar to uniprot|Q12497 Saccharomyces cerevisiae YDR070C FMP16 Putative protein of unknown function; proposed to be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S07e01662g	similar to uniprot|P39944 Saccharomyces cerevisiae YER144C (ohnolog of YDR069C) UBP5 Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck
LALA0_S07e01684g	similar to uniprot|P54858 Saccharomyces cerevisiae YDR068W DOS2 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S07e01706g	similar to uniprot|Q6Q559 Saccharomyces cerevisiae YDR067C OCA6 Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT
LALA0_S07e01728g	similar to uniprot|P22134 Saccharomyces cerevisiae YER142C MAG1 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired
LALA0_S07e01750g	similar to uniprot|P40086 Saccharomyces cerevisiae YER141W COX15 Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
LALA0_S07e01772g	similar to uniprot|P40085 Saccharomyces cerevisiae YER140W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; genetic interactions suggest a role in folding of ER membrane proteins
LALA0_S07e01794g	similar to uniprot|P40084 Saccharomyces cerevisiae YER139C (ohnolog of YDR066C) RTR1 CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm
LALA0_S07e01816g	similar to uniprot|Q6Q5U4 Saccharomyces cerevisiae YDR065W RRG1 Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S07e01838g	highly similar to uniprot|P05756 Saccharomyces cerevisiae YDR064W RPS13 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins
LALA0_S07e01860g	similar to uniprot|Q12156 Saccharomyces cerevisiae YDR063W AIM7 Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss
LALA0_S07e01882g	highly similar to uniprot|P40970 Saccharomyces cerevisiae YDR062W LCB2 Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
LALA0_S07e01904g	similar to uniprot|Q12298 Saccharomyces cerevisiae YDR061W Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
LALA0_S07e01926g	similar to uniprot|P39106 Saccharomyces cerevisiae YER001W MNN1 Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
LALA0_S07e01948g	highly similar to uniprot|P39958 Saccharomyces cerevisiae YER136W GDI1 GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
LALA0_S07e01970g	highly similar to uniprot|P38203 Saccharomyces cerevisiae YBL026W LSM2 Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
LALA0_S07e01992g	weakly similar to uniprot|P40083 Saccharomyces cerevisiae YER137C Putative protein of unknown function
LALA0_S07e02014g	similar to uniprot|P38204 Saccharomyces cerevisiae YBL025W RRN10 Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
LALA0_S07e02036g	highly similar to uniprot|P38205 Saccharomyces cerevisiae YBL024W NCL1 S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
LALA0_S07e02058g	highly similar to uniprot|P29469 Saccharomyces cerevisiae YBL023C MCM2 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
LALA0_S07e02080g	similar to Lachancea thermotolerans KLTH0G09680g hypothetical protein
LALA0_S07e02102g	similar to uniprot|P38067 Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm
LALA0_S07e02124g	similar to uniprot|P36775 Saccharomyces cerevisiae YBL022C PIM1 ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
LALA0_S07e02146g	similar to uniprot|P13434 Saccharomyces cerevisiae YBL021C HAP3 Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
LALA0_S07e02168g	similar to uniprot|P38206 Saccharomyces cerevisiae YBL020W RFT1 Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
LALA0_S07e02190g	similar to uniprot|P38207 Saccharomyces cerevisiae YBL019W APN2 Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
LALA0_S07e02212g	weakly similar to uniprot|P38208 Saccharomyces cerevisiae YBL018C POP8 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
LALA0_S07e02234g	similar to uniprot|P32319 Saccharomyces cerevisiae YBL017C PEP1 Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
LALA0_S07e02256g	highly similar to uniprot|P16892 Saccharomyces cerevisiae YBL016W FUS3 Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
LALA0_S07e02278g	weakly similar to uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
LALA0_S07e02300g	similar to uniprot|P00812 Saccharomyces cerevisiae YPL111W CAR1 Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
LALA0_S07e02322g	similar to uniprot|P28000 Saccharomyces cerevisiae YNL113W RPC19 RNA polymerase subunit AC19, common to RNA polymerases I and III
LALA0_S07e02344g	similar to uniprot|P32621 Saccharomyces cerevisiae YEL042W GDA1 Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
LALA0_S07e02366g	similar to uniprot|P32622 Saccharomyces cerevisiae YEL041W (ohnolog of YJR049C) YEF1 ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes
LALA0_S07e02388g	similar to uniprot|P32623 Saccharomyces cerevisiae YEL040W UTR2 Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
LALA0_S07e02410g	highly similar to uniprot|P00045 Saccharomyces cerevisiae YEL039C (ohnolog of YJR048W CYC1) CYC7 Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
LALA0_S07e02432g	similar to uniprot|P32626 Saccharomyces cerevisiae YEL038W UTR4 Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus
LALA0_S07e02454g	similar to uniprot|P32628 Saccharomyces cerevisiae YEL037C RAD23 Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover
LALA0_S07e02476g	similar to uniprot|P32629 Saccharomyces cerevisiae YEL036C ANP1 Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
LALA0_S07e02498g	highly similar to uniprot|P23301 Saccharomyces cerevisiae YEL034W (ohnolog of YJR047C ANB1) HYP2 Translation elongation factor eIF-5A that may function in translation initiation; similar to and functionally redundant with Anb1p; structural homolog of bacterial EF-P; undergoes an essential hypusination modification
LALA0_S07e02520g	similar to uniprot|P24279 Saccharomyces cerevisiae YEL032W MCM3 Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
LALA0_S07e02542g	highly similar to uniprot|P39986 Saccharomyces cerevisiae YEL031W SPF1 P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
LALA0_S07e02564g	similar to uniprot|P47112 Saccharomyces cerevisiae YJR046W TAH11 DNA replication licensing factor, required for pre-replication complex assembly
LALA0_S07e02586g	similar to uniprot|P32807 Saccharomyces cerevisiae YMR284W YKU70 Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
LALA0_S07e02608g	similar to uniprot|Q03264 Saccharomyces cerevisiae YMR285C (ohnolog of YML118W) NGL2 Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p
LALA0_S07e02630g	highly similar to uniprot|P20084 Saccharomyces cerevisiae YMR286W MRPL33 Mitochondrial ribosomal protein of the large subunit
LALA0_S07e02652g	weakly similar to uniprot|Q03208 Saccharomyces cerevisiae YML119W Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
LALA0_S07e02674g	similar to uniprot|P39112 Saccharomyces cerevisiae YMR287C DSS1 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
LALA0_S07e02696g	similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S07e02718g	similar to uniprot|P40433 Saccharomyces cerevisiae YIL107C PFK26 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
LALA0_S07e02740g	similar to uniprot|P40483 Saccharomyces cerevisiae YIL108W Putative metalloprotease
LALA0_S07e02762g	similar to uniprot|P40482 Saccharomyces cerevisiae YIL109C (ohnolog of YNL049C) SEC24 Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
LALA0_S07e02784g	weakly similar to uniprot|P53952 Saccharomyces cerevisiae YNL050C Putative protein of unknown function; YNL050c is not an essential gene
LALA0_S07e02806g	similar to uniprot|P53951 Saccharomyces cerevisiae YNL051W COG5 Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
LALA0_S07e02828g	similar to uniprot|P40481 Saccharomyces cerevisiae YIL110W HPM1 AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance
LALA0_S07e02850g	highly similar to uniprot|P00425 Saccharomyces cerevisiae YIL111W (ohnolog of YNL052W) COX5B Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
LALA0_S07e02872g	similar to uniprot|P40480 Saccharomyces cerevisiae YIL112W HOS4 Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
LALA0_S07e02894g	weakly similar to uniprot|P40479 Saccharomyces cerevisiae YIL113W (ohnolog of YNL053W) SDP1 Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
LALA0_S07e02916g	similar to Lachancea thermotolerans KLTH0C02156g hypothetical protein
LALA0_S07e02938g	similar to uniprot|P17442 Saccharomyces cerevisiae YGR233C PHO81 Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p
LALA0_S07e02960g	similar to uniprot|P50086 Saccharomyces cerevisiae YGR232W NAS6 Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
LALA0_S07e02982g	highly similar to uniprot|P50085 Saccharomyces cerevisiae YGR231C PHB2 Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
LALA0_S07e03004g	some similarities with uniprot|P17123 Saccharomyces cerevisiae YHR152W (ohnolog of YGR230W) SPO12 Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
LALA0_S07e03026g	similar to uniprot|P50082 Saccharomyces cerevisiae YGR225W AMA1 Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis
LALA0_S07e03048g	similar to uniprot|P38848 Saccharomyces cerevisiae YHR150W PEX28 Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
LALA0_S07e03070g	similar to uniprot|P38849 Saccharomyces cerevisiae YHR151C MTC6 Protein of unknown function; mtc6 is synthetically sick with cdc13-1
LALA0_S07e03092g	similar to uniprot|P50076 Saccharomyces cerevisiae YGR227W DIE2 Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1
LALA0_S07e03114g	similar to uniprot|P32566 Saccharomyces cerevisiae YGR229C SMI1 Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
LALA0_S07e03136g	similar to uniprot|P50079 Saccharomyces cerevisiae YGR223C HSV2 Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
LALA0_S07e03158g	similar to uniprot|P10834 Saccharomyces cerevisiae YGR222W PET54 Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing
LALA0_S07e03202g	weakly similar to uniprot|P32900 Saccharomyces cerevisiae YHR149C (ohnolog of YGR221C) SKG6 Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
LALA0_S07e03224g	highly similar to uniprot|P32899 Saccharomyces cerevisiae YHR148W IMP3 Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
LALA0_S07e03246g	similar to uniprot|P32904 Saccharomyces cerevisiae YHR147C MRPL6 Mitochondrial ribosomal protein of the large subunit
LALA0_S07e03268g	highly similar to uniprot|P31334 Saccharomyces cerevisiae YGR220C MRPL9 Mitochondrial ribosomal protein of the large subunit
LALA0_S07e03290g	highly similar to uniprot|P30822 Saccharomyces cerevisiae YGR218W CRM1 Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin
LALA0_S07e03312g	similar to uniprot|P50077 Saccharomyces cerevisiae YGR217W CCH1 Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
LALA0_S07e03334g	similar to uniprot|P53306 Saccharomyces cerevisiae YGR216C GPI1 Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
LALA0_S07e03356g	highly similar to uniprot|P53305 Saccharomyces cerevisiae YGR215W RSM27 Mitochondrial ribosomal protein of the small subunit
LALA0_S07e03378g	highly similar to uniprot|P32905 Saccharomyces cerevisiae YGR214W (ohnolog of YLR048W) RPS0A Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
LALA0_S07e03400g	similar to uniprot|Q12209 Saccharomyces cerevisiae YLR047C FRE8 Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
LALA0_S07e03422g	similar to uniprot|C5DDM7 Lachancea thermotolerans KLTH0C02266g hypothetical protein
LALA0_S07e03444g	similar to uniprot|P53304 Saccharomyces cerevisiae YGR212W SLI1 N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
LALA0_S07e03466g	highly similar to uniprot|P53303 Saccharomyces cerevisiae YGR211W ZPR1 Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)
LALA0_S07e03510g	weakly similar to uniprot|P36038 Saccharomyces cerevisiae YKL208W CBT1 Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
LALA0_S07e03532g	similar to uniprot|C5DDN4 Lachancea thermotolerans KLTH0C02420g hypothetical protein
LALA0_S07e03554g	similar to uniprot|P36039 Saccharomyces cerevisiae YKL207W AIM27 Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response
LALA0_S07e03576g	highly similar to uniprot|P47122 Saccharomyces cerevisiae YJR072C NPA3 Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex
LALA0_S07e03598g	similar to uniprot|P36040 Saccharomyces cerevisiae YKL206C ADD66 Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
LALA0_S07e03620g	highly similar to uniprot|P47120 Saccharomyces cerevisiae YJR070C LIA1 Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
LALA0_S07e03642g	similar to uniprot|P47119 Saccharomyces cerevisiae YJR069C HAM1 Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine
LALA0_S07e03664g	similar to uniprot|P33418 Saccharomyces cerevisiae YKL205W LOS1 Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
LALA0_S07e03686g	similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein
LALA0_S07e03708g	similar to uniprot|P40348 Saccharomyces cerevisiae YJR068W RFC2 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
LALA0_S07e03730g	similar to uniprot|P47118 Saccharomyces cerevisiae YJR067C YAE1 Protein of unknown function, essential for growth under standard (aerobic) conditions but not under anaerobic conditions
LALA0_S07e03752g	highly similar to uniprot|P32600 Saccharomyces cerevisiae YKL203C (ohnolog of YJR066W) TOR2 PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis
LALA0_S07e03774g	highly similar to uniprot|P47117 Saccharomyces cerevisiae YJR065C ARP3 Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
LALA0_S07e03796g	highly similar to uniprot|P40413 Saccharomyces cerevisiae YJR064W CCT5 Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
LALA0_S07e03818g	highly similar to uniprot|P32529 Saccharomyces cerevisiae YJR063W RPA12 RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
LALA0_S07e03840g	weakly similar to uniprot|P36044 Saccharomyces cerevisiae YKL201C (ohnolog of YJR061W) MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases
LALA0_S07e03862g	similar to uniprot|P40354 Saccharomyces cerevisiae YJR062C NTA1 Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation
LALA0_S07e03884g	weakly similar to uniprot|P36044 Saccharomyces cerevisiae YKL201C (ohnolog of YJR061W) MNN4 Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases
LALA0_S07e03906g	weakly similar to uniprot|P17106 Saccharomyces cerevisiae YJR060W CBF1 Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation
LALA0_S07e03950g	weakly similar to uniprot|P36002 Saccharomyces cerevisiae YKL198C (ohnolog of YJR059W) PTK1 Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
LALA0_S07e03972g	similar to uniprot|P24004 Saccharomyces cerevisiae YKL197C PEX1 AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis
LALA0_S07e03994g	highly similar to uniprot|Q00381 Saccharomyces cerevisiae YJR058C APS2 Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
LALA0_S07e04016g	similar to uniprot|P00572 Saccharomyces cerevisiae YJR057W CDC8 Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
LALA0_S07e04060g	similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein
LALA0_S07e04082g	weakly similar to uniprot|P47115 Saccharomyces cerevisiae YJR056C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S07e04104g	similar to uniprot|P54003 Saccharomyces cerevisiae YML052W SUR7 Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
LALA0_S07e04126g	similar to uniprot|P04387 Saccharomyces cerevisiae YML051W GAL80 Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
LALA0_S07e04148g	similar to uniprot|P46973 Saccharomyces cerevisiae YJR055W HIT1 Protein of unknown function, required for growth at high temperature
LALA0_S07e04170g	similar to uniprot|Q04689 Saccharomyces cerevisiae YML050W AIM32 Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss
LALA0_S07e04192g	similar to uniprot|Q04693 Saccharomyces cerevisiae YML049C RSE1 Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport
LALA0_S07e04214g	similar to uniprot|Q04697 Saccharomyces cerevisiae YML048W GSF2 ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
LALA0_S07e04236g	similar to uniprot|P87284 Saccharomyces cerevisiae YDR276C PMP3 Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
LALA0_S07e04302g	weakly similar to uniprot|P38870 Saccharomyces cerevisiae YHR182W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm
LALA0_S07e04324g	highly similar to uniprot|P38869 Saccharomyces cerevisiae YHR181W SVP26 Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
LALA0_S07e04368g	similar to uniprot|P38699 Saccharomyces cerevisiae YHR178W STB5 Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro
LALA0_S07e04390g	similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
LALA0_S07e04412g	similar to uniprot|P38865 Saccharomyces cerevisiae YHR175W CTR2 Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation
LALA0_S07e04434g	highly similar to uniprot|P00925 Saccharomyces cerevisiae YHR174W (ohnolog of YGR254W) ENO2 Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
LALA0_S07e04500g	similar to uniprot|P38863 Saccharomyces cerevisiae YHR172W SPC97 Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
LALA0_S07e04522g	weakly similar to uniprot|P53857 Saccharomyces cerevisiae YNL234W Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1
LALA0_S07e04544g	weakly similar to uniprot|P53858 Saccharomyces cerevisiae YNL233W BNI4 Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
LALA0_S07e04566g	similar to uniprot|P53859 Saccharomyces cerevisiae YNL232W CSL4 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
LALA0_S07e04588g	similar to uniprot|P53860 Saccharomyces cerevisiae YNL231C PDR16 Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
LALA0_S07e04610g	similar to uniprot|P53379 Saccharomyces cerevisiae YDR144C (ohnolog of YLR120C) MKC7 GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
LALA0_S07e04632g	similar to uniprot|P53861 Saccharomyces cerevisiae YNL230C ELA1 Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex
LALA0_S07e04654g	similar to uniprot|P23202 Saccharomyces cerevisiae YNL229C URE2 Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
LALA0_S07e04676g	similar to uniprot|P53863 Saccharomyces cerevisiae YNL227C JJJ1 Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
LALA0_S07e04698g	similar to uniprot|C5DB75 Lachancea thermotolerans KLTH0A00110g hypothetical protein
LALA0_S07e04720g	similar to uniprot|P53866 Saccharomyces cerevisiae YNL224C SQS1 Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles
LALA0_S07e04742g	similar to uniprot|Q08485 Saccharomyces cerevisiae YOR071C NRT1 High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
LALA0_S07e04764g	similar to uniprot|P53867 Saccharomyces cerevisiae YNL223W ATG4 Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation
LALA0_S07e04786g	highly similar to uniprot|P53538 Saccharomyces cerevisiae YNL222W SSU72 Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo
LALA0_S07e04808g	similar to uniprot|Q07729 Saccharomyces cerevisiae YDL238C GUD1 Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
LALA0_S07e04830g	similar to uniprot|P19262 Saccharomyces cerevisiae YDR148C KGD2 Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
LALA0_S07e04852g	similar to uniprot|Q03764 Saccharomyces cerevisiae YDR147W (ohnolog of YLR133W) EKI1 Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway
LALA0_S07e04874g	weakly similar to uniprot|Q12208 Saccharomyces cerevisiae YLR132C Essential protein of unknown function; fluorescent protein (GFP or YFP)-tagged protein localizes to mitochondria, cytoplasm and nucleus
LALA0_S07e04896g	weakly similar to uniprot|P08153 Saccharomyces cerevisiae YDR146C (ohnolog of YLR131C) SWI5 Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
LALA0_S07e04918g	highly similar to uniprot|Q12220 Saccharomyces cerevisiae YLR129W DIP2 Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
LALA0_S07e04940g	similar to uniprot|Q03761 Saccharomyces cerevisiae YDR145W TAF12 Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
LALA0_S07e04962g	similar to uniprot|Q12395 Saccharomyces cerevisiae YLR128W DCN1 Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
LALA0_S07e04984g	similar to uniprot|Q7LGV7 Saccharomyces cerevisiae YLR127C APC2 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
LALA0_S07e05006g	weakly similar to uniprot|P22470 Saccharomyces cerevisiae YDR143C SAN1 Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition
LALA0_S07e05028g	similar to uniprot|P39108 Saccharomyces cerevisiae YDR142C PEX7 Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)
LALA0_S07e05050g	weakly similar to uniprot|Q99176 Saccharomyces cerevisiae YLR119W SRN2 Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
LALA0_S07e05072g	similar to uniprot|Q12354 Saccharomyces cerevisiae YLR118C Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS
LALA0_S07e05094g	similar to uniprot|Q03921 Saccharomyces cerevisiae YDR141C DOP1 Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies
LALA0_S07e05116g	similar to uniprot|Q03920 Saccharomyces cerevisiae YDR140W MTQ2 S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
LALA0_S07e05138g	highly similar to uniprot|Q03919 Saccharomyces cerevisiae YDR139C RUB1 Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
LALA0_S07e05160g	similar to uniprot|Q12309 Saccharomyces cerevisiae YLR117C CLF1 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
LALA0_S07e05182g	similar to uniprot|Q12186 Saccharomyces cerevisiae YLR116W MSL5 Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
LALA0_S07e05204g	similar to uniprot|Q12102 Saccharomyces cerevisiae YLR115W CFT2 Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.
LALA0_S07e05226g	weakly similar to uniprot|P17629 Saccharomyces cerevisiae YDR138W HPR1 Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p
LALA0_S07e05248g	similar to uniprot|Q12500 Saccharomyces cerevisiae YLR114C AVL9 Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms
LALA0_S07e05270g	similar to uniprot|P16664 Saccharomyces cerevisiae YDR137W RGP1 Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
LALA0_S07e05314g	highly similar to uniprot|P39109 Saccharomyces cerevisiae YDR135C YCF1 Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR
LALA0_S07e05336g	highly similar to uniprot|P32485 Saccharomyces cerevisiae YLR113W HOG1 Mitogen-activated protein kinase involved in osmoregulation; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
LALA0_S07e05358g	similar to uniprot|Q12127 Saccharomyces cerevisiae YLR110C (ohnolog of YDR133C) CCW12 Cell wall mannoprotein with a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip
LALA0_S07e05380g	similar to uniprot|Q03900 Saccharomyces cerevisiae YDR132C (ohnolog of YLR108C) Putative protein of unknown function
LALA0_S07e05424g	weakly similar to uniprot|Q03899 Saccharomyces cerevisiae YDR131C F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex
LALA0_S07e05446g	weakly similar to uniprot|Q03898 Saccharomyces cerevisiae YDR130C FIN1 Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells; localization cell-cycle dependent; involved in Glc7p localization and regulation
LALA0_S07e05468g	similar to uniprot|Q7LI70 Saccharomyces cerevisiae YLR107W REX3 RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases
LALA0_S07e05490g	similar to uniprot|Q12019 Saccharomyces cerevisiae YLR106C MDN1 Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
LALA0_S07e05512g	similar to uniprot|P16658 Saccharomyces cerevisiae YLR105C SEN2 Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
LALA0_S07e05534g	similar to uniprot|Q08045 Saccharomyces cerevisiae YLR104W LCL2 Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
LALA0_S07e05556g	similar to uniprot|Q08032 Saccharomyces cerevisiae YLR103C CDC45 DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
LALA0_S07e05578g	weakly similar to uniprot|Q12107 Saccharomyces cerevisiae YLR102C APC9 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
LALA0_S07e05600g	highly similar to uniprot|P32599 Saccharomyces cerevisiae YDR129C SAC6 Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
LALA0_S07e05622g	highly similar to uniprot|Q12452 Saccharomyces cerevisiae YLR100W ERG27 3-keto sterol reductase, catalyzes the last of three steps required to remove two C- 4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs
LALA0_S07e05644g	similar to uniprot|Q03897 Saccharomyces cerevisiae YDR128W MTC5 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13- 1
LALA0_S07e05666g	highly similar to uniprot|P08566 Saccharomyces cerevisiae YDR127W ARO1 Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
LALA0_S07e05688g	similar to uniprot|C5DN04 Lachancea thermotolerans KLTH0G13134g hypothetical protein
LALA0_S07e05710g	similar to uniprot|Q04629 Saccharomyces cerevisiae YDR126W SWF1 Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion
LALA0_S07e05732g	similar to uniprot|C5DN35 Lachancea thermotolerans KLTH0G13816g hypothetical protein
LALA0_S07e05754g	some similarities with uniprot|Q3E798 Saccharomyces cerevisiae YLR099W-A Putative protein of unknown function
LALA0_S07e05776g	similar to uniprot|Q04623 Saccharomyces cerevisiae YDR125C (ohnolog of YLR099C) ECM18 Protein of unknown function, similar to Rlp24p
LALA0_S07e05798g	weakly similar to uniprot|Q04608 Saccharomyces cerevisiae YDR124W Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
LALA0_S07e05820g	similar to uniprot|Q12347 Saccharomyces cerevisiae YLR097C HRT3 Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
LALA0_S07e05842g	weakly similar to uniprot|P26798 Saccharomyces cerevisiae YDR123C INO2 Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
LALA0_S07e05864g	similar to uniprot|P13185 Saccharomyces cerevisiae YDR122W (ohnolog of YLR096W) KIN1 Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
LALA0_S07e05886g	weakly similar to uniprot|Q12072 Saccharomyces cerevisiae YLR095C IOC2 Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
LALA0_S07e05908g	weakly similar to uniprot|Q7LGX3 Saccharomyces cerevisiae YLR094C GIS3 Protein of unknown function
LALA0_S07e05930g	weakly similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
LALA0_S07e05952g	similar to uniprot|Q12255 Saccharomyces cerevisiae YLR093C NYV1 v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
LALA0_S07e05974g	similar to uniprot|Q04603 Saccharomyces cerevisiae YDR121W DPB4 Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing
LALA0_S07e05996g	similar to uniprot|P15565 Saccharomyces cerevisiae YDR120C TRM1 tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
LALA0_S07e06018g	weakly similar to uniprot|Q2V2P9 Saccharomyces cerevisiae YDR119W-A Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase)
LALA0_S07e06040g	weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane
LALA0_S07e06062g	similar to uniprot|Q12325 Saccharomyces cerevisiae YLR092W SUL2 High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
LALA0_S07e06084g	weakly similar to uniprot|Q04601 Saccharomyces cerevisiae YDR118W APC4 Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis
LALA0_S07e06106g	similar to uniprot|Q04600 Saccharomyces cerevisiae YDR117C TMA64 Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
LALA0_S07e06128g	similar to uniprot|Q04599 Saccharomyces cerevisiae YDR116C MRPL1 Mitochondrial ribosomal protein of the large subunit
LALA0_S07e06150g	similar to uniprot|Q04598 Saccharomyces cerevisiae YDR115W Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins
LALA0_S07e06172g	weakly similar to uniprot|Q12393 Saccharomyces cerevisiae YLR091W GEP5 Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
LALA0_S07e06194g	weakly similar to uniprot|P40316 Saccharomyces cerevisiae YDR113C PDS1 Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
LALA0_S07e06216g	similar to uniprot|P39102 Saccharomyces cerevisiae YLR090W XDJ1 Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S07e06238g	similar to uniprot|P52892 Saccharomyces cerevisiae YDR111C (ohnolog of YLR089C) ALT2 Putative alanine transaminase (glutamic pyruvic transaminase)
LALA0_S07e06260g	weakly similar to uniprot|O13329 Saccharomyces cerevisiae YDR110W FOB1 Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases
LALA0_S07e06282g	similar to uniprot|P39012 Saccharomyces cerevisiae YLR088W GAA1 Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
LALA0_S07e06304g	similar to uniprot|Q12150 Saccharomyces cerevisiae YLR087C CSF1 Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S07e06326g	similar to uniprot|Q12267 Saccharomyces cerevisiae YLR086W SMC4 Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate
LALA0_S07e06348g	similar to uniprot|Q12509 Saccharomyces cerevisiae YLR085C ARP6 Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
LALA0_S07e06370g	similar to uniprot|Q04585 Saccharomyces cerevisiae YDR109C Putative kinase
LALA0_S07e06392g	similar to uniprot|C5DN41 Lachancea thermotolerans KLTH0G13970g putative actin-related protein
LALA0_S07e06414g	similar to uniprot|Q12465 Saccharomyces cerevisiae YLR084C RAX2 N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
LALA0_S07e06436g	similar to uniprot|P46944 Saccharomyces cerevisiae YDR108W TRS85 Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
LALA0_S07e06458g	similar to uniprot|Q04562 Saccharomyces cerevisiae YDR107C (ohnolog of YLR083C) TMN2 Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
LALA0_S07e06502g	similar to uniprot|Q3E784 Saccharomyces cerevisiae YER180C-A SLO1 Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
LALA0_S07e06524g	weakly similar to uniprot|P32645 Saccharomyces cerevisiae YER180C ISC10 Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells
LALA0_S07e06546g	some similarities with uniprot|C5DN79 Lachancea thermotolerans KLTH0G14828g hypothetical protein
LALA0_S07e06568g	highly similar to uniprot|Q12116 Saccharomyces cerevisiae YDR105C TMS1 Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance
LALA0_S07e06590g	highly similar to uniprot|P25453 Saccharomyces cerevisiae YER179W DMC1 Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein
LALA0_S07e06612g	similar to uniprot|Q03862 Saccharomyces cerevisiae YDR101C ARX1 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
LALA0_S07e06634g	highly similar to uniprot|P16387 Saccharomyces cerevisiae YER178W PDA1 E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
LALA0_S07e06656g	weakly similar to uniprot|P32917 Saccharomyces cerevisiae YDR103W STE5 Pheromone-response scaffold protein that controls the mating decision; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p
LALA0_S07e06678g	weakly similar to uniprot|Q03868 Saccharomyces cerevisiae YDR104C SPO71 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
LALA0_S07e06700g	similar to uniprot|Q03860 Saccharomyces cerevisiae YDR100W TVP15 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
LALA0_S07e06722g	highly similar to uniprot|P29311 Saccharomyces cerevisiae YER177W (ohnolog of YDR099W) BMH1 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
LALA0_S07e06766g	similar to uniprot|P32644 Saccharomyces cerevisiae YER176W ECM32 DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
LALA0_S07e06788g	similar to uniprot|P32643 Saccharomyces cerevisiae YER175C TMT1 Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
LALA0_S07e06810g	similar to uniprot|P32642 Saccharomyces cerevisiae YER174C (ohnolog of YDR098C) GRX4 Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance
LALA0_S07e06832g	similar to uniprot|P32641 Saccharomyces cerevisiae YER173W RAD24 Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein
LALA0_S07e06854g	similar to uniprot|P32639 Saccharomyces cerevisiae YER172C BRR2 RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
LALA0_S07e06876g	highly similar to uniprot|P06839 Saccharomyces cerevisiae YER171W RAD3 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance
LALA0_S07e06898g	similar to uniprot|P26364 Saccharomyces cerevisiae YER170W ADK2 Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
LALA0_S07e06920g	highly similar to uniprot|P04147 Saccharomyces cerevisiae YER165W PAB1 Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
LALA0_S07e06942g	some similarities with uniprot|P52490 Saccharomyces cerevisiae YDR092W UBC13 Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
LALA0_S07e06964g	similar to uniprot|P32660 Saccharomyces cerevisiae YER166W (ohnolog of YDR093W) DNF1 Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
LALA0_S07e06986g	weakly similar to uniprot|P33306 Saccharomyces cerevisiae YER167W BCK2 Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
LALA0_S07e07008g	similar to uniprot|P21269 Saccharomyces cerevisiae YER168C CCA1 ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
LALA0_S07e07030g	similar to uniprot|P39956 Saccharomyces cerevisiae YER169W (ohnolog of YDR096W) RPH1 JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri-and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
LALA0_S07e07052g	similar to uniprot|Q03834 Saccharomyces cerevisiae YDR097C MSH6 Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p
LALA0_S07e07074g	similar to uniprot|P32657 Saccharomyces cerevisiae YER164W CHD1 Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes
LALA0_S07e07096g	highly similar to uniprot|Q03195 Saccharomyces cerevisiae YDR091C RLI1 Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase
LALA0_S07e07118g	similar to uniprot|Q03193 Saccharomyces cerevisiae YDR090C Putative protein of unknown function
LALA0_S07e07140g	similar to uniprot|P14736 Saccharomyces cerevisiae YER162C RAD4 Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
LALA0_S07e07162g	similar to uniprot|P06843 Saccharomyces cerevisiae YER161C SPT2 Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins
LALA0_S07e07184g	similar to uniprot|P38966 Saccharomyces cerevisiae YDR089W Protein of unknown function; deletion confers resistance to Nickel
LALA0_S07e07206g	similar to uniprot|Q02775 Saccharomyces cerevisiae YDR088C SLU7 RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
LALA0_S07e07228g	similar to uniprot|P35178 Saccharomyces cerevisiae YDR087C RRP1 Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
LALA0_S07e07250g	similar to uniprot|P35179 Saccharomyces cerevisiae YDR086C SSS1 Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
LALA0_S07e07272g	similar to uniprot|P40096 Saccharomyces cerevisiae YER159C BUR6 Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
LALA0_S07e07294g	weakly similar to uniprot|P33413 Saccharomyces cerevisiae YHL016C DUR3 Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
LALA0_S07e07316g	weakly similar to uniprot|P40095 Saccharomyces cerevisiae YER158C (ohnolog of YDR085C) Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
LALA0_S07e07338g	similar to uniprot|P38962 Saccharomyces cerevisiae YDR084C TVP23 Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S07e07360g	similar to uniprot|P38961 Saccharomyces cerevisiae YDR083W RRP8 Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation
LALA0_S07e07382g	similar to uniprot|P34166 Saccharomyces cerevisiae YNL145W MFA2 Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
LALA0_S07e07404g	similar to uniprot|Q12349 Saccharomyces cerevisiae YLR295C ATP14 Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
LALA0_S07e07426g	similar to uniprot|C5DM03 Lachancea thermotolerans KLTH0G04906g hypothetical protein
LALA0_S07e07448g	highly similar to uniprot|P32836 Saccharomyces cerevisiae YOR185C (ohnolog of YLR293C) GSP2 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability
LALA0_S07e07470g	similar to uniprot|P39742 Saccharomyces cerevisiae YLR292C SEC72 Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
LALA0_S07e07492g	similar to uniprot|P32502 Saccharomyces cerevisiae YLR291C GCD7 Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
LALA0_S07e07514g	similar to uniprot|Q05892 Saccharomyces cerevisiae YLR290C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene
LALA0_S07e07536g	highly similar to uniprot|P46943 Saccharomyces cerevisiae YLR289W GUF1 Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
LALA0_S07e07558g	similar to uniprot|Q02574 Saccharomyces cerevisiae YLR288C MEC3 DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
LALA0_S07e07580g	highly similar to uniprot|P33330 Saccharomyces cerevisiae YOR184W SER1 3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p
LALA0_S07e07602g	highly similar to uniprot|Q12087 Saccharomyces cerevisiae YOR182C (ohnolog of YLR287C-A) RPS30B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein
LALA0_S07e07624g	similar to uniprot|Q05881 Saccharomyces cerevisiae YLR287C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene
LALA0_S07e07646g	highly similar to uniprot|P38910 Saccharomyces cerevisiae YOR020C HSP10 Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
LALA0_S07e07668g	similar to uniprot|Q12446 Saccharomyces cerevisiae YOR181W LAS17 Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
LALA0_S07e07690g	weakly similar to uniprot|P47046 Saccharomyces cerevisiae YJL051W IRC8 Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc
LALA0_S07e07712g	similar to uniprot|P40335 Saccharomyces cerevisiae YJL053W PEP8 Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport
LALA0_S07e07734g	similar to uniprot|P47045 Saccharomyces cerevisiae YJL054W TIM54 Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
LALA0_S07e07756g	weakly similar to uniprot|Q03654 Saccharomyces cerevisiae YMR213W CEF1 Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
LALA0_S07e07778g	similar to uniprot|P47044 Saccharomyces cerevisiae YJL055W Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU
LALA0_S08e00100g	some similarities with uniprot|Q2US70 Aspergillus oryzae AOR_1_960174 hypothetical protein
LALA0_S08e00122g	similar to uniprot|Q2US70 Aspergillus oryzae AOR_1_960174 hypothetical protein
LALA0_S08e00144g	similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
LALA0_S08e00166g	some similarities with uniprot|P40896 Saccharomyces cerevisiae YJL213W Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
LALA0_S08e00188g	weakly similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
LALA0_S08e00210g	hypothetical protein
LALA0_S08e00232g	similar to uniprot|P04397 Saccharomyces cerevisiae YBR019C GAL10 UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
LALA0_S08e00254g	some similarities with uniprot|P13045 Saccharomyces cerevisiae YDR009W (ohnolog of YBR020W) GAL3 Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
LALA0_S08e00276g	highly similar to uniprot|P08431 Saccharomyces cerevisiae YBR018C GAL7 Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
LALA0_S08e00298g	some similarities with uniprot|G2QVF1 Thielavia terrestris THITE_2040324 hypothetical protein
LALA0_S08e00320g	similar to uniprot|P53058 Saccharomyces cerevisiae YGL258W VEL1 Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
LALA0_S08e00342g	weakly similar to Lachancea thermotolerans KLTH0E00176g hypothetical protein
LALA0_S08e00364g	similar to uniprot|P34251 Saccharomyces cerevisiae YKL107W Putative protein of unknown function; proposed to be a palmitoylated membrane protein
LALA0_S08e00386g	similar to uniprot|Q12068 Saccharomyces cerevisiae YOL151W GRE2 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
LALA0_S08e00408g	similar to uniprot|Q6BVQ7 Debaryomyces hansenii DEHA2C00726g hypothetical protein
LALA0_S08e00430g	similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W YCT1 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
LALA0_S08e00452g	similar to uniprot|P53918 Saccharomyces cerevisiae YNL125C ESBP6 Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
LALA0_S08e00474g	similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W (ohnolog of YPR058W) YMC2 Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
LALA0_S08e00496g	similar to uniprot|Q07589 Saccharomyces cerevisiae YDL144C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene.
LALA0_S08e00518g	some similarities with uniprot|P25653 Saccharomyces cerevisiae YCR089W (ohnolog of YNR044W) FIG2 Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating
LALA0_S08e00540g	weakly similar to uniprot|P52923 Saccharomyces cerevisiae YNR074C AIF1 Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
LALA0_S08e00562g	weakly similar to uniprot|P38866 Saccharomyces cerevisiae YHR176W FMO1 Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
LALA0_S08e00584g	some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p
LALA0_S08e00606g	similar to uniprot|C5DES4 Lachancea thermotolerans KLTH0C11682g hypothetical protein
LALA0_S08e00650g	highly similar to uniprot|P41819 Saccharomyces cerevisiae YPL266W DIM1 Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
LALA0_S08e00672g	weakly similar to uniprot|C5DES4 Lachancea thermotolerans KLTH0C11682g hypothetical protein
LALA0_S08e00694g	similar to uniprot|P32383 Saccharomyces cerevisiae YPL268W PLC1 Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes
LALA0_S08e00716g	weakly similar to uniprot|P32526 Saccharomyces cerevisiae YPL269W KAR9 Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
LALA0_S08e00738g	similar to uniprot|P33311 Saccharomyces cerevisiae YPL270W MDL2 Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
LALA0_S08e00760g	similar to uniprot|P21306 Saccharomyces cerevisiae YPL271W ATP15 Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
LALA0_S08e00782g	similar to uniprot|P39985 Saccharomyces cerevisiae YEL055C POL5 DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
LALA0_S08e00804g	weakly similar to uniprot|Q08984 Saccharomyces cerevisiae YPL272C Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
LALA0_S08e00826g	similar to uniprot|P39984 Saccharomyces cerevisiae YEL056W HAT2 Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
LALA0_S08e00848g	similar to uniprot|Q08979 Saccharomyces cerevisiae YPL263C KEL3 Cytoplasmic protein of unknown function
LALA0_S08e00870g	similar to uniprot|P38628 Saccharomyces cerevisiae YEL058W PCM1 Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
LALA0_S08e00892g	similar to uniprot|Q05676 Saccharomyces cerevisiae YEL059C-A SOM1 Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
LALA0_S08e00914g	highly similar to uniprot|P08417 Saccharomyces cerevisiae YPL262W FUM1 Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
LALA0_S08e00936g	similar to uniprot|P53296 Saccharomyces cerevisiae YGR177C ATF2 Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
LALA0_S08e00958g	weakly similar to uniprot|P32644 Saccharomyces cerevisiae YER176W ECM32 DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
LALA0_S08e00980g	similar to uniprot|P09232 Saccharomyces cerevisiae YEL060C (ohnolog of YOR003W) PRB1 Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p
LALA0_S08e01002g	hypothetical protein
LALA0_S08e01024g	similar to uniprot|Q12339 Saccharomyces cerevisiae YOR004W UTP23 Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
LALA0_S08e01046g	similar to uniprot|P27895 Saccharomyces cerevisiae YEL061C CIN8 Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
LALA0_S08e01068g	similar to uniprot|P39923 Saccharomyces cerevisiae YEL062W NPR2 Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation; subunit of SEA (Seh1-associated) complex; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline
LALA0_S08e01090g	similar to uniprot|Q08387 Saccharomyces cerevisiae YOR005C DNL4 DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
LALA0_S08e01112g	similar to uniprot|Q12094 Saccharomyces cerevisiae YOR006C TSR3 Protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S08e01134g	some similarities with uniprot|Q04263 Saccharomyces cerevisiae YML002W Putative protein of unknown function; expression induced by heat and by calcium shortage
LALA0_S08e01156g	similar to uniprot|Q12118 Saccharomyces cerevisiae YOR007C SGT2 Glutamine-rich cytoplasmic protein that serves as a scaffold for binding Get4/5p and other proteins required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; has similarity to human cochaperone SGT
LALA0_S08e01200g	similar to uniprot|Q12001 Saccharomyces cerevisiae YOR002W ALG6 Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
LALA0_S08e01222g	highly similar to Lachancea thermotolerans KLTH0D00242g hypothetical protein
LALA0_S08e01244g	highly similar to uniprot|P32939 Saccharomyces cerevisiae YML001W YPT7 Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7
LALA0_S08e01266g	similar to uniprot|P20052 Saccharomyces cerevisiae YOL001W PHO80 Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling
LALA0_S08e01288g	similar to uniprot|Q12149 Saccharomyces cerevisiae YOR001W RRP6 Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
LALA0_S08e01310g	similar to uniprot|Q12442 Saccharomyces cerevisiae YOL002C IZH2 Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
LALA0_S08e01354g	similar to uniprot|Q12006 Saccharomyces cerevisiae YOL003C PFA4 Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
LALA0_S08e01376g	similar to uniprot|P22579 Saccharomyces cerevisiae YOL004W SIN3 Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity
LALA0_S08e01398g	highly similar to uniprot|P38902 Saccharomyces cerevisiae YOL005C RPB11 RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
LALA0_S08e01420g	highly similar to uniprot|P32562 Saccharomyces cerevisiae YMR001C CDC5 Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate
LALA0_S08e01442g	highly similar to uniprot|P04786 Saccharomyces cerevisiae YOL006C TOP1 Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
LALA0_S08e01464g	weakly similar to uniprot|Q08054 Saccharomyces cerevisiae YOL007C CSI2 Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
LALA0_S08e01486g	similar to uniprot|Q03667 Saccharomyces cerevisiae YMR002W MIC17 Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs
LALA0_S08e01508g	some similarities with uniprot|Q03673 Saccharomyces cerevisiae YMR003W AIM34 Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss
LALA0_S08e01530g	weakly similar to uniprot|Q08058 Saccharomyces cerevisiae YOL008W COQ10 Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
LALA0_S08e01552g	similar to uniprot|Q92328 Saccharomyces cerevisiae YOL009C MDM12 Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins
LALA0_S08e01574g	similar to uniprot|P40959 Saccharomyces cerevisiae YMR004W MVP1 Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole
LALA0_S08e01596g	highly similar to uniprot|Q08096 Saccharomyces cerevisiae YOL010W RCL1 Subunit of U3-containing 90S preribosome processome complex involved in 18S rRNA biogenesis and small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no activity detected
LALA0_S08e01618g	weakly similar to uniprot|C5DEN2 Lachancea thermotolerans KLTH0C10626g hypothetical protein
LALA0_S08e01640g	similar to uniprot|P50105 Saccharomyces cerevisiae YMR005W TAF4 TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
LALA0_S08e01684g	similar to uniprot|Q08108 Saccharomyces cerevisiae YOL011W (ohnolog of YMR008C) PLB3 Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
LALA0_S08e01706g	highly similar to uniprot|P38361 Saccharomyces cerevisiae YBR296C PHO89 Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
LALA0_S08e01728g	highly similar to uniprot|Q12692 Saccharomyces cerevisiae YOL012C HTZ1 Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
LALA0_S08e01750g	similar to Lachancea thermotolerans KLTH0C10252g hypothetical protein
LALA0_S08e01772g	similar to uniprot|Q08109 Saccharomyces cerevisiae YOL013C HRD1 Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger
LALA0_S08e01794g	similar to uniprot|Q04712 Saccharomyces cerevisiae YML043C RRN11 Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
LALA0_S08e01838g	weakly similar to uniprot|P53729 Saccharomyces cerevisiae YNR029C Putative protein of unknown function, deletion confers reduced fitness in saline
LALA0_S08e01860g	highly similar to uniprot|P19882 Saccharomyces cerevisiae YLR259C HSP60 Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
LALA0_S08e01882g	weakly similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
LALA0_S08e01904g	similar to uniprot|Q12246 Saccharomyces cerevisiae YOR171C (ohnolog of YLR260W) LCB4 Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
LALA0_S08e01926g	highly similar to uniprot|Q99260 Saccharomyces cerevisiae YLR262C YPT6 Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
LALA0_S08e01948g	highly similar to uniprot|Q3E764 Saccharomyces cerevisiae YLR262C-A TMA7 Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin
LALA0_S08e01970g	highly similar to uniprot|P13188 Saccharomyces cerevisiae YOR168W GLN4 Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions
LALA0_S08e01992g	weakly similar to uniprot|P14291 Saccharomyces cerevisiae YLR263W RED1 Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p
LALA0_S08e02014g	some similarities with uniprot|Q3E7X9 Saccharomyces cerevisiae YOR167C (ohnolog of YLR264W) RPS28A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein
LALA0_S08e02036g	similar to uniprot|Q12104 Saccharomyces cerevisiae YOR166C SWT1 RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain
LALA0_S08e02058g	weakly similar to uniprot|C5DBL9 Lachancea thermotolerans KLTH0A03674g hypothetical protein
LALA0_S08e02080g	similar to uniprot|Q99287 Saccharomyces cerevisiae YOR165W SEY1 GTPase with a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; possible functional ortholog of mammalian atlastins, defects in which cause a form of hereditary spastic paraplegia; homolog of Arabidopsis RHD3
LALA0_S08e02102g	similar to uniprot|Q12125 Saccharomyces cerevisiae YOR164C GET4 Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
LALA0_S08e02124g	similar to uniprot|Q99321 Saccharomyces cerevisiae YOR163W DDP1 Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa-and pentaphosphates; exhibits endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; member of the MutT family of nucleotide hydrolases
LALA0_S08e02146g	similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
LALA0_S08e02168g	similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
LALA0_S08e02190g	weakly similar to uniprot|Q6B2M3 Saccharomyces cerevisiae YOR172W (ohnolog of YLR266C) YRM1 Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes
LALA0_S08e02212g	similar to uniprot|Q99316 Saccharomyces cerevisiae YOL088C MPD2 Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p
LALA0_S08e02234g	similar to uniprot|P38281 Saccharomyces cerevisiae YBR151W APD1 Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
LALA0_S08e02256g	weakly similar to uniprot|P38114 Saccharomyces cerevisiae YBR150C (ohnolog of YOL089C) TBS1 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S08e02278g	similar to uniprot|P38115 Saccharomyces cerevisiae YBR149W ARA1 NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
LALA0_S08e02300g	highly similar to uniprot|P25847 Saccharomyces cerevisiae YOL090W MSH2 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
LALA0_S08e02322g	weakly similar to uniprot|P38280 Saccharomyces cerevisiae YBR148W (ohnolog of YOL091W) YSW1 Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
LALA0_S08e02344g	similar to uniprot|P38279 Saccharomyces cerevisiae YBR147W (ohnolog of YOL092W) RTC2 Protein of unknown function; mutant produces large lipid droplets, is resistant to fluconazole, has decreased levels of rDNA transcription, growth defects on minimal media, and suppresses cdc13-1; detected in highly purified mitochondria; similar to a G-protein coupled receptor from S. pombe
LALA0_S08e02366g	similar to uniprot|Q12400 Saccharomyces cerevisiae YOL093W TRM10 tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs
LALA0_S08e02388g	highly similar to uniprot|P40339 Saccharomyces cerevisiae YOL094C RFC4 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
LALA0_S08e02410g	similar to uniprot|P39904 Saccharomyces cerevisiae YDR484W VPS52 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin
LALA0_S08e02432g	similar to uniprot|Q05379 Saccharomyces cerevisiae YOL095C HMI1 Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
LALA0_S08e02454g	similar to uniprot|Q03388 Saccharomyces cerevisiae YDR485C VPS72 Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
LALA0_S08e02476g	similar to uniprot|P27680 Saccharomyces cerevisiae YOL096C COQ3 O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein
LALA0_S08e02498g	similar to uniprot|Q03390 Saccharomyces cerevisiae YDR486C VPS60 Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
LALA0_S08e02520g	highly similar to uniprot|Q12109 Saccharomyces cerevisiae YOL097C WRS1 Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
LALA0_S08e02542g	similar to uniprot|Q99258 Saccharomyces cerevisiae YDR487C RIB3 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
LALA0_S08e02586g	weakly similar to uniprot|P40960 Saccharomyces cerevisiae YDR488C PAC11 Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
LALA0_S08e02608g	similar to uniprot|Q6Q558 Saccharomyces cerevisiae YDR489W SLD5 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
LALA0_S08e02630g	similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W (ohnolog of YOR120W) YPR1 NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases
LALA0_S08e02652g	similar to uniprot|P15380 Saccharomyces cerevisiae YOR348C PUT4 Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
LALA0_S08e02674g	weakly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
LALA0_S08e02696g	similar to uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
LALA0_S08e02718g	weakly similar to uniprot|P40185 Saccharomyces cerevisiae YIL051C (ohnolog of YER057C) MMF1 Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
LALA0_S08e02740g	similar to uniprot|P07256 Saccharomyces cerevisiae YBL045C COR1 Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
LALA0_S08e02762g	weakly similar to uniprot|P38193 Saccharomyces cerevisiae YBL046W PSY4 Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
LALA0_S08e02784g	similar to uniprot|P47150 Saccharomyces cerevisiae YJR113C RSM7 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
LALA0_S08e02806g	similar to uniprot|Q3E743 Saccharomyces cerevisiae YJR112W-A Putative protein of unknown function; identified based on homology to Ashbya gossypii
LALA0_S08e02850g	similar to uniprot|P34216 Saccharomyces cerevisiae YBL047C EDE1 Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins
LALA0_S08e02872g	similar to uniprot|P47149 Saccharomyces cerevisiae YJR112W NNF1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
LALA0_S08e02894g	highly similar to uniprot|P40527 Saccharomyces cerevisiae YIL048W NEO1 Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
LALA0_S08e02916g	similar to uniprot|P40528 Saccharomyces cerevisiae YIL047C SYG1 Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
LALA0_S08e02938g	highly similar to uniprot|P00498 Saccharomyces cerevisiae YER055C HIS1 ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
LALA0_S08e02960g	similar to uniprot|P39014 Saccharomyces cerevisiae YIL046W MET30 F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
LALA0_S08e02982g	weakly similar to uniprot|P40187 Saccharomyces cerevisiae YIL045W (ohnolog of YER054C) PIG2 Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
LALA0_S08e03004g	similar to uniprot|Q3E7B0 Saccharomyces cerevisiae YER053C-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
LALA0_S08e03026g	similar to uniprot|P40035 Saccharomyces cerevisiae YER053C PIC2 Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
LALA0_S08e03048g	similar to uniprot|P40529 Saccharomyces cerevisiae YIL044C AGE2 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif
LALA0_S08e03070g	some similarities with uniprot|P00175 Saccharomyces cerevisiae YML054C CYB2 Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
LALA0_S08e03092g	highly similar to uniprot|P10869 Saccharomyces cerevisiae YER052C HOM3 Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
LALA0_S08e03114g	similar to uniprot|P38626 Saccharomyces cerevisiae YIL043C CBR1 Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
LALA0_S08e03136g	similar to uniprot|P40034 Saccharomyces cerevisiae YER051W JHD1 JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
LALA0_S08e03158g	similar to uniprot|P40033 Saccharomyces cerevisiae YER050C RSM18 Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
LALA0_S08e03180g	similar to uniprot|P40530 Saccharomyces cerevisiae YIL042C PKP1 Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
LALA0_S08e03202g	similar to uniprot|P40531 Saccharomyces cerevisiae YIL041W GVP36 BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
LALA0_S08e03224g	similar to uniprot|P40032 Saccharomyces cerevisiae YER049W TPA1 Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
LALA0_S08e03246g	similar to uniprot|Q6Q560 Saccharomyces cerevisiae YER048W-A ISD11 Protein required for mitochondrial iron-sulfur cluster biosynthesis
LALA0_S08e03290g	weakly similar to uniprot|P40532 Saccharomyces cerevisiae YIL040W APQ12 Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
LALA0_S08e03312g	similar to uniprot|P39101 Saccharomyces cerevisiae YER048C CAJ1 Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
LALA0_S08e03334g	similar to uniprot|P40533 Saccharomyces cerevisiae YIL039W TED1 Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
LALA0_S08e03356g	similar to uniprot|P39955 Saccharomyces cerevisiae YER047C SAP1 Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system
LALA0_S08e03378g	highly similar to uniprot|C5DBJ4 Lachancea thermotolerans KLTH0A03124g hypothetical protein
LALA0_S08e03400g	similar to uniprot|P06102 Saccharomyces cerevisiae YIL038C NOT3 Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
LALA0_S08e03422g	weakly similar to uniprot|P40534 Saccharomyces cerevisiae YIL037C PRM2 Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion
LALA0_S08e03444g	some similarities with uniprot|P40031 Saccharomyces cerevisiae YER046W SPO73 Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
LALA0_S08e03466g	some similarities with uniprot|P40535 Saccharomyces cerevisiae YIL036W (ohnolog of YER045C) CST6 Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability
LALA0_S08e03488g	weakly similar to uniprot|P29467 Saccharomyces cerevisiae YER044C-A MEI4 Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores
LALA0_S08e03510g	highly similar to uniprot|P15790 Saccharomyces cerevisiae YIL035C CKA1 Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
LALA0_S08e03532g	similar to uniprot|P13517 Saccharomyces cerevisiae YIL034C CAP2 Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
LALA0_S08e03554g	similar to uniprot|Q12458 Saccharomyces cerevisiae YDR368W (ohnolog of YOR120W) YPR1 NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases
LALA0_S08e03576g	highly similar to uniprot|P40030 Saccharomyces cerevisiae YER044C ERG28 Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p
LALA0_S08e03598g	similar to uniprot|P07278 Saccharomyces cerevisiae YIL033C BCY1 Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
LALA0_S08e03620g	similar to uniprot|P43610 Saccharomyces cerevisiae YFR038W IRC5 Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci
LALA0_S08e03642g	similar to uniprot|P43609 Saccharomyces cerevisiae YFR037C RSC8 Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
LALA0_S08e03664g	similar to uniprot|P53237 Saccharomyces cerevisiae YGR057C LST7 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
LALA0_S08e03686g	highly similar to uniprot|Q05911 Saccharomyces cerevisiae YLR359W ADE13 Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
LALA0_S08e03708g	similar to uniprot|P53236 Saccharomyces cerevisiae YGR056W (ohnolog of YLR357W) RSC1 Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
LALA0_S08e03730g	weakly similar to uniprot|P53687 Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
LALA0_S08e03752g	highly similar to uniprot|P50276 Saccharomyces cerevisiae YGR055W MUP1 High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
LALA0_S08e03774g	similar to uniprot|D6VTK4 Saccharomyces cerevisiae YFL026W STE2 Receptor for alpha-factor pheromone; seventransmembrane-domain GPCR that interacts with bothpheromone and a heterotrimeric G protein to initiate thesignaling response that leads to mating between haploid aand alpha cells
LALA0_S08e03796g	similar to uniprot|P43571 Saccharomyces cerevisiae YFL025C BST1 GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
LALA0_S08e03818g	similar to uniprot|P43572 Saccharomyces cerevisiae YFL024C EPL1 Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
LALA0_S08e03840g	weakly similar to uniprot|P39552 Saccharomyces cerevisiae YAR033W MST28 Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles
LALA0_S08e03862g	similar to uniprot|P43573 Saccharomyces cerevisiae YFL023W BUD27 Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding
LALA0_S08e03884g	weakly similar to uniprot|P22148 Saccharomyces cerevisiae YOL116W MSN1 Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus
LALA0_S08e03906g	similar to uniprot|Q12202 Saccharomyces cerevisiae YLR054C OSW2 Protein of unknown function proposed to be involved in the assembly of the spore wall
LALA0_S08e03928g	weakly similar to Lachancea thermotolerans KLTH0A02838g hypothetical protein
LALA0_S08e03950g	highly similar to uniprot|P15625 Saccharomyces cerevisiae YFL022C FRS2 Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
LALA0_S08e03972g	weakly similar to uniprot|Q12345 Saccharomyces cerevisiae YLR052W IES3 Subunit of the INO80 chromatin remodeling complex
LALA0_S08e03994g	similar to uniprot|Q12035 Saccharomyces cerevisiae YLR051C FCF2 Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon
LALA0_S08e04016g	weakly similar to uniprot|P43574 Saccharomyces cerevisiae YFL021W GAT1 Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
LALA0_S08e04060g	highly similar to uniprot|P09624 Saccharomyces cerevisiae YFL018C (ohnolog of YPL017C) LPD1 Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
LALA0_S08e04104g	similar to uniprot|P40204 Saccharomyces cerevisiae YFL017W-A SMX2 Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
LALA0_S08e04126g	similar to uniprot|P43577 Saccharomyces cerevisiae YFL017C GNA1 Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
LALA0_S08e04148g	similar to uniprot|Q12155 Saccharomyces cerevisiae YLR050C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
LALA0_S08e04170g	similar to uniprot|P35191 Saccharomyces cerevisiae YFL016C MDJ1 Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
LALA0_S08e04192g	similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
LALA0_S08e04214g	similar to uniprot|P22943 Saccharomyces cerevisiae YFL014W HSP12 Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; regulated by HOG and Ras-Pka pathways
LALA0_S08e04236g	weakly similar to uniprot|C5DBH9 Lachancea thermotolerans KLTH0A02772g hypothetical protein
LALA0_S08e04258g	similar to uniprot|P43579 Saccharomyces cerevisiae YFL013C IES1 Subunit of the INO80 chromatin remodeling complex
LALA0_S08e04280g	similar to uniprot|P43582 Saccharomyces cerevisiae YFL010C WWM1 WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1
LALA0_S08e04302g	similar to uniprot|C5DBH7 Lachancea thermotolerans KLTH0A02728g hypothetical protein
LALA0_S08e04324g	similar to uniprot|P07834 Saccharomyces cerevisiae YFL009W CDC4 F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p
LALA0_S08e04346g	similar to uniprot|C5DCQ7 Lachancea thermotolerans KLTH0B05038g hypothetical protein
LALA0_S08e04368g	similar to uniprot|P32908 Saccharomyces cerevisiae YFL008W SMC1 Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
LALA0_S08e04390g	similar to uniprot|P43583 Saccharomyces cerevisiae YFL007W BLM10 Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
LALA0_S08e04412g	highly similar to uniprot|P07560 Saccharomyces cerevisiae YFL005W SEC4 Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
LALA0_S08e04434g	some similarities with uniprot|C5DIT1 Lachancea thermotolerans KLTH0E14938g hypothetical protein
LALA0_S08e04456g	similar to uniprot|C5DIT1 Lachancea thermotolerans KLTH0E14938g hypothetical protein
LALA0_S08e04478g	similar to uniprot|P43585 Saccharomyces cerevisiae YFL004W (ohnolog of YPL019C) VTC2 Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
LALA0_S08e04500g	similar to uniprot|P47161 Saccharomyces cerevisiae YJR126C VPS70 Protein of unknown function involved in vacuolar protein sorting
LALA0_S08e04522g	highly similar to uniprot|P25719 Saccharomyces cerevisiae YML078W CPR3 Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria
LALA0_S08e04544g	similar to uniprot|P47160 Saccharomyces cerevisiae YJR125C ENT3 Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p
LALA0_S08e04566g	similar to uniprot|Q03630 Saccharomyces cerevisiae YML077W BET5 Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi
LALA0_S08e04588g	weakly similar to uniprot|Q03631 Saccharomyces cerevisiae YML076C WAR1 Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
LALA0_S08e04610g	hypothetical protein
LALA0_S08e04632g	similar to uniprot|P12683 Saccharomyces cerevisiae YML075C (ohnolog of YLR450W) HMG1 One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
LALA0_S08e04654g	similar to uniprot|P38911 Saccharomyces cerevisiae YML074C (ohnolog of YLR449W) FPR3 Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
LALA0_S08e04698g	highly similar to uniprot|P38219 Saccharomyces cerevisiae YBR025C OLA1 P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide
LALA0_S08e04720g	similar to uniprot|P23833 Saccharomyces cerevisiae YBR037C (ohnolog of YBR024W) SCO1 Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins
LALA0_S08e04742g	similar to uniprot|P14180 Saccharomyces cerevisiae YBR038W CHS2 Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis
LALA0_S08e04764g	highly similar to Lachancea thermotolerans KLTH0A01848g hypothetical protein
LALA0_S08e04786g	similar to uniprot|P29465 Saccharomyces cerevisiae YBR023C CHS3 Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
LALA0_S08e04808g	similar to uniprot|P38218 Saccharomyces cerevisiae YBR022W POA1 Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
LALA0_S08e04830g	similar to uniprot|P32568 Saccharomyces cerevisiae YDR011W SNQ2 Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species
LALA0_S08e04852g	similar to uniprot|P13045 Saccharomyces cerevisiae YDR009W (ohnolog of YBR020W) GAL3 Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity
LALA0_S08e04874g	some similarities with uniprot|C5DBG4 Lachancea thermotolerans KLTH0A02398g hypothetical protein
LALA0_S08e04918g	similar to uniprot|P43590 Saccharomyces cerevisiae YFR006W Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene
LALA0_S08e04940g	similar to uniprot|P43589 Saccharomyces cerevisiae YFR005C SAD1 Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
LALA0_S08e04962g	highly similar to uniprot|P43588 Saccharomyces cerevisiae YFR004W RPN11 Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes
LALA0_S08e04984g	similar to uniprot|P43587 Saccharomyces cerevisiae YFR003C YPI1 Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen
LALA0_S08e05006g	similar to uniprot|P34077 Saccharomyces cerevisiae YFR002W NIC96 Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p
LALA0_S08e05028g	similar to uniprot|P43586 Saccharomyces cerevisiae YFR001W LOC1 Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
LALA0_S08e05138g	similar to uniprot|Q12341 Saccharomyces cerevisiae YPL001W HAT1 Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
LALA0_S08e05160g	similar to uniprot|Q12483 Saccharomyces cerevisiae YPL002C SNF8 Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
LALA0_S08e05182g	similar to uniprot|P31115 Saccharomyces cerevisiae YFL001W DEG1 tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
LALA0_S08e05204g	similar to uniprot|P25808 Saccharomyces cerevisiae YFL002C SPB4 Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
LALA0_S08e05226g	weakly similar to uniprot|Q12059 Saccharomyces cerevisiae YPL003W ULA1 Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
LALA0_S08e05248g	highly similar to uniprot|Q12230 Saccharomyces cerevisiae YPL004C LSP1 Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
LALA0_S08e05270g	similar to uniprot|Q12089 Saccharomyces cerevisiae YPL005W AEP3 Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
LALA0_S08e05292g	similar to uniprot|Q12200 Saccharomyces cerevisiae YPL006W NCR1 Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
LALA0_S08e05314g	similar to uniprot|Q12308 Saccharomyces cerevisiae YPL007C TFC8 One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
LALA0_S08e05336g	similar to uniprot|P22516 Saccharomyces cerevisiae YPL008W CHL1 Probable DNA helicase involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member
LALA0_S08e05358g	similar to uniprot|C5DBG4 Lachancea thermotolerans KLTH0A02398g hypothetical protein
LALA0_S08e05380g	hypothetical protein
LALA0_S08e05402g	weakly similar to uniprot|Q02606 Saccharomyces cerevisiae YPL014W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
LALA0_S08e05424g	similar to uniprot|Q02608 Saccharomyces cerevisiae YPL013C MRPS16 Mitochondrial ribosomal protein of the small subunit
LALA0_S08e05446g	similar to uniprot|Q7LH12 Saccharomyces cerevisiae YPL012W RRP12 Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
LALA0_S08e05468g	similar to uniprot|Q12297 Saccharomyces cerevisiae YPL011C TAF3 TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
LALA0_S08e05490g	similar to uniprot|P53600 Saccharomyces cerevisiae YPL010W RET3 Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
LALA0_S08e05512g	similar to uniprot|Q12532 Saccharomyces cerevisiae YPL009C TAE2 Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S08e05556g	similar to uniprot|P53686 Saccharomyces cerevisiae YPL015C HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
LALA0_S08e05578g	similar to uniprot|Q02724 Saccharomyces cerevisiae YPL020C ULP1 Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions
LALA0_S08e05600g	similar to uniprot|Q03629 Saccharomyces cerevisiae YML079W Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
LALA0_S08e05622g	similar to uniprot|P53759 Saccharomyces cerevisiae YML080W DUS1 Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
LALA0_S08e05644g	similar to uniprot|Q04545 Saccharomyces cerevisiae YML081W (ohnolog of YJR127C) TDA9 DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene
LALA0_S08e05666g	similar to uniprot|C5DGC9 Lachancea thermotolerans KLTH0D04290g hypothetical protein
LALA0_S08e05688g	similar to uniprot|P47163 Saccharomyces cerevisiae YJR129C Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S08e05710g	similar to uniprot|P25335 Saccharomyces cerevisiae YIR029W DAL2 Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
LALA0_S08e05732g	similar to uniprot|Q04458 Saccharomyces cerevisiae YMR110C HFD1 Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome
LALA0_S08e05754g	highly similar to uniprot|Q04439 Saccharomyces cerevisiae YMR109W (ohnolog of YKL129C) MYO5 One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
LALA0_S08e05776g	highly similar to uniprot|P07342 Saccharomyces cerevisiae YMR108W ILV2 Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
LALA0_S08e05798g	similar to uniprot|Q04438 Saccharomyces cerevisiae YMR107W SPG4 Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
LALA0_S08e05820g	highly similar to uniprot|P38011 Saccharomyces cerevisiae YMR116C ASC1 G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
LALA0_S08e05842g	similar to uniprot|P36000 Saccharomyces cerevisiae YKL135C APL2 Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting
LALA0_S08e05864g	similar to uniprot|P36064 Saccharomyces cerevisiae YKL137W CMC1 Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
LALA0_S08e05886g	similar to uniprot|P14063 Saccharomyces cerevisiae YKL138C MRPL31 Mitochondrial ribosomal protein of the large subunit
LALA0_S08e05908g	similar to uniprot|Q04477 Saccharomyces cerevisiae YMR117C SPC24 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
LALA0_S08e05930g	similar to uniprot|P69852 Saccharomyces cerevisiae YKL138C-A HSK3 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
LALA0_S08e05952g	similar to uniprot|Q03957 Saccharomyces cerevisiae YKL139W CTK1 Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
LALA0_S08e05974g	similar to uniprot|P34163 Saccharomyces cerevisiae YKL140W TGL1 Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
LALA0_S08e05996g	similar to uniprot|Q04487 Saccharomyces cerevisiae YMR118C (ohnolog of YKL141W) Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
LALA0_S08e06018g	similar to uniprot|C5DGB7 Lachancea thermotolerans KLTH0D04004g hypothetical protein
LALA0_S08e06040g	similar to uniprot|P39929 Saccharomyces cerevisiae YLR025W SNF7 One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
LALA0_S08e06062g	similar to uniprot|Q01590 Saccharomyces cerevisiae YLR026C SED5 cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
LALA0_S08e06084g	weakly similar to uniprot|Q04301 Saccharomyces cerevisiae YMR088C VBA1 Permease of basic amino acids in the vacuolar membrane
LALA0_S08e06106g	highly similar to uniprot|P23542 Saccharomyces cerevisiae YLR027C AAT2 Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
LALA0_S08e06150g	similar to uniprot|P39927 Saccharomyces cerevisiae YGR156W PTI1 Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
LALA0_S08e06172g	similar to uniprot|P25299 Saccharomyces cerevisiae YGL044C RNA15 Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
LALA0_S08e06194g	similar to uniprot|P07273 Saccharomyces cerevisiae YGL043W DST1 General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites
LALA0_S08e06216g	similar to uniprot|P0C5N3 Saccharomyces cerevisiae YGL041W-A Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry
LALA0_S08e06238g	highly similar to uniprot|P32582 Saccharomyces cerevisiae YGR155W CYS4 Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria
LALA0_S08e06260g	similar to uniprot|Q04272 Saccharomyces cerevisiae YMR077C VPS20 Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
LALA0_S08e06282g	highly similar to uniprot|P05373 Saccharomyces cerevisiae YGL040C HEM2 Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
LALA0_S08e06304g	similar to uniprot|C5DGB7 Lachancea thermotolerans KLTH0D04004g hypothetical protein
LALA0_S08e06326g	similar to uniprot|P05374 Saccharomyces cerevisiae YGR157W CHO2 Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
LALA0_S08e06348g	similar to uniprot|P48240 Saccharomyces cerevisiae YGR158C MTR3 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
LALA0_S08e06370g	similar to uniprot|P53180 Saccharomyces cerevisiae YGL045W RIM8 Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
LALA0_S08e06392g	similar to uniprot|P27476 Saccharomyces cerevisiae YGR159C NSR1 Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
LALA0_S08e06414g	hypothetical protein
LALA0_S08e06436g	similar to uniprot|C5DG83 Lachancea thermotolerans KLTH0D03146g hypothetical protein
LALA0_S08e06458g	similar to uniprot|P53178 Saccharomyces cerevisiae YGL047W ALG13 Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases
LALA0_S08e06480g	highly similar to uniprot|Q01939 Saccharomyces cerevisiae YGL048C RPT6 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle
LALA0_S08e06502g	similar to uniprot|P39935 Saccharomyces cerevisiae YGR162W (ohnolog of YGL049C) TIF4631 Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit
LALA0_S08e06524g	similar to uniprot|P53177 Saccharomyces cerevisiae YGL050W TYW3 tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
LALA0_S08e06546g	highly similar to uniprot|P53290 Saccharomyces cerevisiae YGR163W GTR2 Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
LALA0_S08e06568g	weakly similar to uniprot|Q12151 Saccharomyces cerevisiae YDR213W (ohnolog of YLR228C) UPC2 Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion
LALA0_S08e06634g	highly similar to uniprot|P06106 Saccharomyces cerevisiae YLR303W MET17 Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis
LALA0_S08e06656g	similar to uniprot|P14772 Saccharomyces cerevisiae YLL015W BPT1 ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p
LALA0_S08e06678g	highly similar to uniprot|P19414 Saccharomyces cerevisiae YLR304C ACO1 Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
LALA0_S08e06700g	similar to uniprot|P37297 Saccharomyces cerevisiae YLR305C STT4 Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
LALA0_S08e06722g	weakly similar to uniprot|P36118 Saccharomyces cerevisiae YKR022C NTR2 Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
LALA0_S08e06744g	weakly similar to uniprot|P46954 Saccharomyces cerevisiae YJL089W SIP4 C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
LALA0_S08e06766g	similar to uniprot|P47027 Saccharomyces cerevisiae YJL090C DPB11 Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1
LALA0_S08e06788g	similar to uniprot|P47026 Saccharomyces cerevisiae YJL091C GWT1 Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
LALA0_S08e06810g	similar to uniprot|P12954 Saccharomyces cerevisiae YJL092W SRS2 DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
LALA0_S08e06832g	similar to uniprot|P40310 Saccharomyces cerevisiae YJL093C TOK1 Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
LALA0_S08e06854g	similar to uniprot|Q01389 Saccharomyces cerevisiae YJL095W BCK1 Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
LALA0_S08e06876g	similar to uniprot|P40858 Saccharomyces cerevisiae YJL096W MRPL49 Mitochondrial ribosomal protein of the large subunit
LALA0_S08e06898g	similar to uniprot|P40857 Saccharomyces cerevisiae YJL097W PHS1 Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking
LALA0_S08e06920g	similar to uniprot|P40856 Saccharomyces cerevisiae YJL098W (ohnolog of YKR028W) SAP185 Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p
LALA0_S08e06942g	similar to uniprot|P40955 Saccharomyces cerevisiae YJL099W (ohnolog of YKR027W) CHS6 Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
LALA0_S08e06964g	similar to uniprot|P42951 Saccharomyces cerevisiae YJL100W LSB6 Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
LALA0_S08e06986g	similar to uniprot|P32477 Saccharomyces cerevisiae YJL101C GSH1 Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury
LALA0_S08e07030g	similar to uniprot|P39677 Saccharomyces cerevisiae YJL102W MEF2 Mitochondrial elongation factor involved in translational elongation
LALA0_S08e07052g	highly similar to uniprot|P14741 Saccharomyces cerevisiae YKR026C GCN3 Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
LALA0_S08e07074g	similar to uniprot|P36121 Saccharomyces cerevisiae YKR025W RPC37 RNA polymerase III subunit C37
LALA0_S08e07096g	similar to uniprot|P36120 Saccharomyces cerevisiae YKR024C DBP7 Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions
LALA0_S08e07118g	similar to uniprot|P36119 Saccharomyces cerevisiae YKR023W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S08e07140g	similar to uniprot|Q6CLI0 Kluyveromyces lactis hypothetical protein
LALA0_S08e07162g	similar to uniprot|P42949 Saccharomyces cerevisiae YJL104W PAM16 Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain
LALA0_S08e07184g	similar to uniprot|P42948 Saccharomyces cerevisiae YJL105W (ohnolog of YKR029C) SET4 Protein of unknown function, contains a SET domain
LALA0_S08e07206g	similar to Lachancea thermotolerans KLTH0D00242g hypothetical protein
LALA0_S08e07228g	similar to uniprot|P32581 Saccharomyces cerevisiae YJL106W IME2 Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
LALA0_S08e07250g	weakly similar to uniprot|C5DNK5 Lachancea thermotolerans KLTH0G17798g hypothetical protein
LALA0_S08e07272g	weakly similar to uniprot|P25354 Saccharomyces cerevisiae YCR007C Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
LALA0_S08e07294g	highly similar to uniprot|P30656 Saccharomyces cerevisiae YPR103W PRE2 Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
LALA0_S08e07316g	similar to uniprot|P39521 Saccharomyces cerevisiae YPR104C FHL1 Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants
LALA0_S08e07338g	similar to uniprot|Q06096 Saccharomyces cerevisiae YPR105C COG4 Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
LALA0_S08e07360g	highly similar to uniprot|P53252 Saccharomyces cerevisiae YGR086C PIL1 Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family
LALA0_S08e07382g	weakly similar to uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
LALA0_S08e07404g	some similarities with uniprot|Q06102 Saccharomyces cerevisiae YPR107C YTH1 Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
LALA0_S08e07426g	weakly similar to uniprot|P38363 Saccharomyces cerevisiae YML132W COS3 Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
LALA0_S08e07448g	highly similar to uniprot|Q06102 Saccharomyces cerevisiae YPR107C YTH1 Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
LALA0_S08e07470g	weakly similar to uniprot|P18411 Saccharomyces cerevisiae YAL008W FUN14 Mitochondrial protein of unknown function
LALA0_S08e07492g	similar to uniprot|P38903 Saccharomyces cerevisiae YOR014W RTS1 B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in absence of Cdc55p; homolog of the mammalian B' subunit of PP2A
LALA0_S08e07514g	similar to uniprot|P18410 Saccharomyces cerevisiae YAL009W SPO7 Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
LALA0_S08e07536g	similar to uniprot|P18409 Saccharomyces cerevisiae YAL010C MDM10 Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins
LALA0_S08e07558g	similar to uniprot|P31376 Saccharomyces cerevisiae YAL011W SWC3 Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
LALA0_S08e07580g	similar to uniprot|Q08204 Saccharomyces cerevisiae YOL034W SMC5 Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
LALA0_S08e07602g	similar to uniprot|P48525 Saccharomyces cerevisiae YOL033W MSE1 Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated
LALA0_S08e07624g	similar to uniprot|Q08202 Saccharomyces cerevisiae YOL032W OPI10 Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline
LALA0_S08e07646g	similar to uniprot|Q6B1H9 Saccharomyces cerevisiae YOL031C SIL1 Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
LALA0_S08e07668g	highly similar to uniprot|P31373 Saccharomyces cerevisiae YAL012W CYS3 Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
LALA0_S08e07690g	highly similar to uniprot|P53228 Saccharomyces cerevisiae YGR043C (ohnolog of YLR354C) NQM1 Transaldolaseof unknown function; transcription is repressed by Mot1pand induced by alpha-factor and during diauxic shift
LALA0_S08e07712g	weakly similar to uniprot|P53227 Saccharomyces cerevisiae YGR042W Putative protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S08e07734g	weakly similar to uniprot|P53226 Saccharomyces cerevisiae YGR041W (ohnolog of YLR353W) BUD9 Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
LALA0_S08e07756g	similar to uniprot|Q06479 Saccharomyces cerevisiae YLR352W Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
LALA0_S08e07778g	highly similar to uniprot|P14681 Saccharomyces cerevisiae YGR040W KSS1 Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
LALA0_S08e07800g	similar to uniprot|P49954 Saccharomyces cerevisiae YLR351C NIT3 Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
LALA0_S08e07822g	highly similar to uniprot|P53224 Saccharomyces cerevisiae YGR038W (ohnolog of YLR350W) ORM1 Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
LALA0_S08e07844g	similar to uniprot|P31787 Saccharomyces cerevisiae YGR037C ACB1 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion
LALA0_S08e07866g	highly similar to uniprot|Q06142 Saccharomyces cerevisiae YLR347C KAP95 Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
LALA0_S08e07888g	similar to uniprot|P53223 Saccharomyces cerevisiae YGR036C CAX4 Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
LALA0_S08e07910g	similar to uniprot|Q06137 Saccharomyces cerevisiae YLR345W Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
LALA0_S08e07932g	highly similar to uniprot|P53221 Saccharomyces cerevisiae YGR034W (ohnolog of YLR344W) RPL26B Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
LALA0_S08e07976g	similar to uniprot|P53220 Saccharomyces cerevisiae YGR033C TIM21 Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity
LALA0_S08e07998g	similar to uniprot|Q06135 Saccharomyces cerevisiae YLR343W GAS2 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p
LALA0_S08e08020g	highly similar to uniprot|P40989 Saccharomyces cerevisiae YGR032W (ohnolog of YLR342W) GSC2 Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
LALA0_S08e08042g	similar to uniprot|P53219 Saccharomyces cerevisiae YGR031W IMO32 Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1
LALA0_S08e08064g	similar to uniprot|C5DNK8 Lachancea thermotolerans KLTH0G17864g hypothetical protein
LALA0_S08e08086g	highly similar to uniprot|P05317 Saccharomyces cerevisiae YLR340W RPP0 Conserved ribosomal protein P0 of the ribosomal stalk, which is involved in interaction between translational elongation factors and the ribosome; similar to rat P0, human P0, and E. coli L10e; phosphorylated on serine 302
LALA0_S08e08108g	weakly similar to uniprot|P53218 Saccharomyces cerevisiae YGR030C POP6 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
LALA0_S08e08130g	similar to uniprot|C5E2R0 Lachancea thermotolerans KLTH0H06996g hypothetical protein
LALA0_S09e00100g	similar to uniprot|Q04089 Saccharomyces cerevisiae YDR440W DOT1 Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response
LALA0_S09e00122g	highly similar to uniprot|P36973 Saccharomyces cerevisiae YDR441C (ohnolog of YML022W) APT2 Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
LALA0_S09e00144g	weakly similar to uniprot|Q03718 Saccharomyces cerevisiae YML023C NSE5 Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair
LALA0_S09e00166g	similar to uniprot|P38931 Saccharomyces cerevisiae YDR443C SSN2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
LALA0_S09e00188g	similar to uniprot|Q04093 Saccharomyces cerevisiae YDR444W Putative protein of unknown function
LALA0_S09e00210g	similar to uniprot|P32891 Saccharomyces cerevisiae YDL174C DLD1 D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
LALA0_S09e00232g	weakly similar to uniprot|Q04110 Saccharomyces cerevisiae YDR446W ECM11 Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
LALA0_S09e00254g	highly similar to uniprot|P14127 Saccharomyces cerevisiae YDR447C (ohnolog of YML024W) RPS17B Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
LALA0_S09e00276g	highly similar to uniprot|Q02336 Saccharomyces cerevisiae YDR448W ADA2 Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
LALA0_S09e00298g	highly similar to uniprot|Q02354 Saccharomyces cerevisiae YDR449C UTP6 Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
LALA0_S09e00320g	similar to uniprot|P51998 Saccharomyces cerevisiae YML025C YML6 Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
LALA0_S09e00342g	highly similar to uniprot|P0CX55 Saccharomyces cerevisiae YDR450W (ohnolog of YML026C) RPS18A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
LALA0_S09e00364g	weakly similar to uniprot|Q04116 Saccharomyces cerevisiae YDR451C (ohnolog of YML027W) YHP1 One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
LALA0_S09e00386g	similar to uniprot|Q04119 Saccharomyces cerevisiae YDR452W PPN1 Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
LALA0_S09e00408g	highly similar to uniprot|Q04120 Saccharomyces cerevisiae YDR453C (ohnolog of YML028W) TSA2 Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
LALA0_S09e00430g	weakly similar to uniprot|Q03714 Saccharomyces cerevisiae YML029W USA1 Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
LALA0_S09e00452g	highly similar to uniprot|Q03713 Saccharomyces cerevisiae YML030W AIM31 Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; may interact with respiratory chain complexes III or IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss
LALA0_S09e00474g	highly similar to uniprot|P15454 Saccharomyces cerevisiae YDR454C GUK1 Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
LALA0_S09e00496g	highly similar to uniprot|Q04121 Saccharomyces cerevisiae YDR456W NHX1 Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
LALA0_S09e00518g	similar to uniprot|P32500 Saccharomyces cerevisiae YML031W NDC1 Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II
LALA0_S09e00540g	similar to uniprot|P06778 Saccharomyces cerevisiae YML032C RAD52 Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
LALA0_S09e00562g	similar to uniprot|Q7LIK7 Saccharomyces cerevisiae YDR457W TOM1 E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones
LALA0_S09e00584g	similar to uniprot|C5DM22 Lachancea thermotolerans KLTH0G05324g hypothetical protein
LALA0_S09e00606g	weakly similar to uniprot|Q03281 Saccharomyces cerevisiae YDR458C (ohnolog of YML034W) HEH2 Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
LALA0_S09e00628g	similar to uniprot|P15274 Saccharomyces cerevisiae YML035C AMD1 AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools
LALA0_S09e00650g	similar to uniprot|Q03289 Saccharomyces cerevisiae YDR459C PFA5 Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
LALA0_S09e00672g	highly similar to uniprot|P89104 Saccharomyces cerevisiae YDR460W TFB3 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
LALA0_S09e00694g	similar to uniprot|Q03705 Saccharomyces cerevisiae YML036W CGI121 Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
LALA0_S09e00716g	weakly similar to uniprot|Q03703 Saccharomyces cerevisiae YML037C Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
LALA0_S09e00738g	similar to uniprot|P36527 Saccharomyces cerevisiae YDR462W MRPL28 Mitochondrial ribosomal protein of the large subunit
LALA0_S09e00760g	similar to uniprot|Q03697 Saccharomyces cerevisiae YML038C YMD8 Putative nucleotide sugar transporter, has similarity to Vrg4p
LALA0_S09e00782g	weakly similar to uniprot|P38704 Saccharomyces cerevisiae YHR006W (ohnolog of YDR463W) STP2 Transcriptionfactor, activated by proteolytic processing in response tosignals from the SPS sensor system for external aminoacids; activates transcription of amino acid permeasegenes
LALA0_S09e00804g	weakly similar to uniprot|P38904 Saccharomyces cerevisiae YDR464W SPP41 Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
LALA0_S09e00826g	highly similar to uniprot|P10614 Saccharomyces cerevisiae YHR007C ERG11 Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
LALA0_S09e00848g	similar to uniprot|Q03305 Saccharomyces cerevisiae YDR465C RMT2 Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67
LALA0_S09e00870g	highly similar to uniprot|P00447 Saccharomyces cerevisiae YHR008C SOD2 Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
LALA0_S09e00892g	some similarities with uniprot|Q03306 Saccharomyces cerevisiae YDR466W PKH3 Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
LALA0_S09e00914g	similar to uniprot|P38758 Saccharomyces cerevisiae YHR009C TDA3 Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1
LALA0_S09e00936g	similar to uniprot|Q03322 Saccharomyces cerevisiae YDR468C TLG1 Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p
LALA0_S09e00958g	some similarities with uniprot|Q03323 Saccharomyces cerevisiae YDR469W SDC1 Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30
LALA0_S09e00980g	similar to uniprot|Q03327 Saccharomyces cerevisiae YDR470C UGO1 Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; facilitates dimerization of Fzo1p during fusion
LALA0_S09e01002g	similar to Lachancea thermotolerans KLTH0G05874g hypothetical protein
LALA0_S09e01024g	highly similar to uniprot|P38706 Saccharomyces cerevisiae YHR010W (ohnolog of YDR471W) RPL27A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
LALA0_S09e01046g	similar to uniprot|P38705 Saccharomyces cerevisiae YHR011W DIA4 Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth
LALA0_S09e01068g	similar to uniprot|P38759 Saccharomyces cerevisiae YHR012W VPS29 Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
LALA0_S09e01090g	similar to uniprot|P07347 Saccharomyces cerevisiae YHR013C ARD1 Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells
LALA0_S09e01112g	similar to uniprot|Q03337 Saccharomyces cerevisiae YDR472W TRS31 One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
LALA0_S09e01134g	weakly similar to uniprot|P23624 Saccharomyces cerevisiae YHR014W SPO13 Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
LALA0_S09e01178g	weakly similar to uniprot|Q12433 Saccharomyces cerevisiae YOR023C AHC1 Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
LALA0_S09e01200g	similar to uniprot|Q12204 Saccharomyces cerevisiae YOR022C Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S09e01222g	highly similar to uniprot|Q12314 Saccharomyces cerevisiae YOR021C Putative protein of unknown function; YOR021C is not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
LALA0_S09e01244g	weakly similar to uniprot|Q3E824 Saccharomyces cerevisiae YOR020W-A Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S09e01266g	similar to uniprot|Q03338 Saccharomyces cerevisiae YDR473C PRP3 Splicing factor, component of the U4/U6-U5 snRNP complex
LALA0_S09e01288g	weakly similar to uniprot|Q03361 Saccharomyces cerevisiae YDR475C (ohnolog of YOR019W) JIP4 Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
LALA0_S09e01310g	some similarities with uniprot|P40994 Saccharomyces cerevisiae YOR094W ARF3 Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
LALA0_S09e01332g	similar to uniprot|Q03362 Saccharomyces cerevisiae YDR476C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
LALA0_S09e01354g	highly similar to uniprot|P06782 Saccharomyces cerevisiae YDR477W SNF1 AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
LALA0_S09e01376g	similar to uniprot|P53687 Saccharomyces cerevisiae YOR025W HST3 Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
LALA0_S09e01398g	weakly similar to uniprot|P29366 Saccharomyces cerevisiae YBR200W BEM1 Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
LALA0_S09e01420g	highly similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
LALA0_S09e01442g	similar to uniprot|P33303 Saccharomyces cerevisiae YJR095W SFC1 Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
LALA0_S09e01464g	highly similar to uniprot|P49631 Saccharomyces cerevisiae YPR043W (ohnolog of YJR094W-A) RPL43A Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
LALA0_S09e01486g	weakly similar to uniprot|C5DM47 Lachancea thermotolerans KLTH0G05940g hypothetical protein
LALA0_S09e01508g	similar to uniprot|P38782 Saccharomyces cerevisiae YHR058C MED6 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
LALA0_S09e01530g	similar to uniprot|P23285 Saccharomyces cerevisiae YHR057C (ohnolog of YDR304C) CPR2 Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
LALA0_S09e01552g	similar to uniprot|C4Y9Y0 Clavispora lusitaniae CLUG_05201 hypothetical protein
LALA0_S09e01574g	similar to uniprot|Q06636 Saccharomyces cerevisiae YDR302W GPI11 ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
LALA0_S09e01596g	similar to uniprot|Q06632 Saccharomyces cerevisiae YDR301W CFT1 RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
LALA0_S09e01618g	highly similar to uniprot|P38690 Saccharomyces cerevisiae YHR033W (ohnolog of YDR300C) Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
LALA0_S09e01640g	similar to uniprot|P38768 Saccharomyces cerevisiae YHR034C PIH1 Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)
LALA0_S09e01662g	weakly similar to uniprot|Q05497 Saccharomyces cerevisiae YDR338C Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
LALA0_S09e01684g	similar to uniprot|Q66RD8 Saccharomyces cerevisiae YDR299W BFR2 Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
LALA0_S09e01706g	similar to uniprot|P09457 Saccharomyces cerevisiae YDR298C ATP5 Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
LALA0_S09e01728g	similar to uniprot|P38992 Saccharomyces cerevisiae YDR297W SUR2 Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
LALA0_S09e01750g	similar to uniprot|Q06630 Saccharomyces cerevisiae YDR296W MHR1 Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
LALA0_S09e01772g	weakly similar to uniprot|P38769 Saccharomyces cerevisiae YHR035W Putative protein of unknown function; not an essential gene
LALA0_S09e01794g	weakly similar to uniprot|Q06629 Saccharomyces cerevisiae YDR295C HDA2 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
LALA0_S09e01816g	similar to uniprot|Q12288 Saccharomyces cerevisiae YLR126C Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein
LALA0_S09e01838g	similar to uniprot|P38770 Saccharomyces cerevisiae YHR036W BRL1 Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
LALA0_S09e01860g	similar to uniprot|Q05567 Saccharomyces cerevisiae YDR294C DPL1 Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
LALA0_S09e01882g	highly similar to uniprot|P07275 Saccharomyces cerevisiae YHR037W PUT2 Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
LALA0_S09e01904g	similar to uniprot|P24276 Saccharomyces cerevisiae YDR293C SSD1 Translational repressor with a role in cell wall polar growth and integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control of specific mRNAs; interacts with TOR pathway components
LALA0_S09e01926g	similar to uniprot|P38771 Saccharomyces cerevisiae YHR038W RRF1 Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
LALA0_S09e01948g	highly similar to uniprot|P38694 Saccharomyces cerevisiae YHR039C MSC7 Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
LALA0_S09e01970g	highly similar to uniprot|P48836 Saccharomyces cerevisiae YHR039C-A VMA10 Subunit G of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification
LALA0_S09e01992g	weakly similar to uniprot|P38772 Saccharomyces cerevisiae YHR040W BCD1 Essential protein required for the accumulation of box C/D snoRNA
LALA0_S09e02014g	weakly similar to uniprot|P21147 Saccharomyces cerevisiae YGL055W OLE1 Delta(9) fatty acid desaturase,required for monounsaturated fatty acid synthesis and fornormal distribution of mitochondria
LALA0_S09e02036g	similar to uniprot|P32916 Saccharomyces cerevisiae YDR292C SRP101 Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p
LALA0_S09e02058g	highly similar to uniprot|Q05549 Saccharomyces cerevisiae YDR291W HRQ1 Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
LALA0_S09e02080g	similar to uniprot|Q05543 Saccharomyces cerevisiae YDR289C RTT103 Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
LALA0_S09e02102g	similar to uniprot|P34162 Saccharomyces cerevisiae YHR041C SRB2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
LALA0_S09e02124g	similar to uniprot|P15442 Saccharomyces cerevisiae YDR283C GCN2 Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
LALA0_S09e02146g	similar to uniprot|Q05521 Saccharomyces cerevisiae YDR284C DPP1 Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
LALA0_S09e02168g	weakly similar to uniprot|P31111 Saccharomyces cerevisiae YDR285W ZIP1 Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate
LALA0_S09e02190g	similar to uniprot|Q05530 Saccharomyces cerevisiae YDR286C Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site
LALA0_S09e02234g	similar to uniprot|Q05533 Saccharomyces cerevisiae YDR287W INM2 Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy
LALA0_S09e02256g	similar to uniprot|Q05541 Saccharomyces cerevisiae YDR288W NSE3 Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth
LALA0_S09e02278g	similar to uniprot|P16603 Saccharomyces cerevisiae YHR042W NCP1 NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
LALA0_S09e02300g	similar to uniprot|Q05648 Saccharomyces cerevisiae YDR282C Putative protein of unknown function
LALA0_S09e02322g	similar to uniprot|P38774 Saccharomyces cerevisiae YHR044C DOG1 2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
LALA0_S09e02344g	highly similar to uniprot|Q05636 Saccharomyces cerevisiae YDR280W RRP45 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9)
LALA0_S09e02366g	similar to uniprot|Q6Q5R1 Saccharomyces cerevisiae YDR279W RNH202 Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
LALA0_S09e02388g	similar to uniprot|P38775 Saccharomyces cerevisiae YHR045W Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
LALA0_S09e02410g	highly similar to uniprot|P38710 Saccharomyces cerevisiae YHR046C INM1 Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
LALA0_S09e02432g	similar to uniprot|P37898 Saccharomyces cerevisiae YHR047C (ohnolog of YKL157W) AAP1 Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
LALA0_S09e02454g	similar to uniprot|P38776 Saccharomyces cerevisiae YHR048W YHK8 Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
LALA0_S09e02476g	highly similar to uniprot|P38777 Saccharomyces cerevisiae YHR049W FSH1 Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2
LALA0_S09e02498g	similar to uniprot|Q12046 Saccharomyces cerevisiae YDL209C CWC2 Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
LALA0_S09e02520g	similar to uniprot|P23394 Saccharomyces cerevisiae YDR243C PRP28 RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
LALA0_S09e02542g	similar to uniprot|P36032 Saccharomyces cerevisiae YKL221W MCH2 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
LALA0_S09e02564g	weakly similar to uniprot|C5DIN5 Lachancea thermotolerans KLTH0E13904g hypothetical protein
LALA0_S09e02586g	similar to uniprot|P35056 Saccharomyces cerevisiae YDR244W PEX5 Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
LALA0_S09e02608g	similar to uniprot|P50108 Saccharomyces cerevisiae YDR245W MNN10 Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
LALA0_S09e02630g	weakly similar to uniprot|P09547 Saccharomyces cerevisiae YPL016W SWI1 Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]
LALA0_S09e02652g	similar to uniprot|P06777 Saccharomyces cerevisiae YPL022W RAD1 Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
LALA0_S09e02674g	highly similar to uniprot|P38116 Saccharomyces cerevisiae YBR164C ARL1 Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
LALA0_S09e02696g	similar to uniprot|Q02981 Saccharomyces cerevisiae YPL109C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S09e02718g	similar to uniprot|Q02979 Saccharomyces cerevisiae YPL110C GDE1 Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes
LALA0_S09e02740g	similar to uniprot|C5DIN8 Lachancea thermotolerans KLTH0E13970g hypothetical protein
LALA0_S09e02762g	similar to uniprot|P30624 Saccharomyces cerevisiae YOR317W (ohnolog of YMR246W) FAA1 Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles
LALA0_S09e02784g	similar to uniprot|C5DIN8 Lachancea thermotolerans KLTH0E13970g hypothetical protein
LALA0_S09e02806g	similar to uniprot|Q04781 Saccharomyces cerevisiae YMR247C RKR1 RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice
LALA0_S09e02828g	similar to uniprot|Q12096 Saccharomyces cerevisiae YOR320C GNT1 N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
LALA0_S09e02850g	similar to uniprot|Q99181 Saccharomyces cerevisiae YOR319W HSH49 U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
LALA0_S09e02872g	similar to uniprot|P21182 Saccharomyces cerevisiae YOL052C SPE2 S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
LALA0_S09e02894g	similar to uniprot|Q04792 Saccharomyces cerevisiae YMR250W GAD1 Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
LALA0_S09e02916g	hypothetical protein
LALA0_S09e02938g	similar to uniprot|Q12355 Saccharomyces cerevisiae YDR055W (ohnolog of YBR078W) PST1 Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
LALA0_S09e02960g	highly similar to uniprot|C5DH44 Lachancea thermotolerans KLTH0E01232g hypothetical protein
LALA0_S09e02982g	similar to uniprot|P38249 Saccharomyces cerevisiae YBR079C RPG1 eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation
LALA0_S09e03004g	highly similar to uniprot|P18759 Saccharomyces cerevisiae YBR080C SEC18 ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF
LALA0_S09e03026g	weakly similar to uniprot|Q12025 Saccharomyces cerevisiae YDR056C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
LALA0_S09e03048g	weakly similar to uniprot|Q04313 Saccharomyces cerevisiae YDR057W YOS9 ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family
LALA0_S09e03070g	similar to uniprot|P35177 Saccharomyces cerevisiae YBR081C SPT7 Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
LALA0_S09e03114g	highly similar to uniprot|P15732 Saccharomyces cerevisiae YDR059C (ohnolog of YBR082C) UBC5 Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible
LALA0_S09e03136g	similar to uniprot|Q12176 Saccharomyces cerevisiae YDR060W MAK21 Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
LALA0_S09e03158g	weakly similar to uniprot|P18412 Saccharomyces cerevisiae YBR083W TEC1 Transcription factor required for full Ty1 expression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member
LALA0_S09e03180g	highly similar to uniprot|P09440 Saccharomyces cerevisiae YBR084W MIS1 Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
LALA0_S09e03202g	highly similar to uniprot|P05735 Saccharomyces cerevisiae YBR084C-A (ohnolog of YBL027W) RPL19A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
LALA0_S09e03224g	similar to uniprot|P38202 Saccharomyces cerevisiae YBL028C Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
LALA0_S09e03246g	weakly similar to uniprot|P38201 Saccharomyces cerevisiae YBL029W Non-essential protein of unknown function
LALA0_S09e03268g	similar to uniprot|Q3E756 Saccharomyces cerevisiae YBL029C-A Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica
LALA0_S09e03290g	weakly similar to uniprot|P38114 Saccharomyces cerevisiae YBR150C (ohnolog of YOL089C) TBS1 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S09e03312g	highly similar to uniprot|P18238 Saccharomyces cerevisiae YBR085W (ohnolog of YBL030C) AAC3 Mitochondrialinner membrane ADP/ATP translocator, exchanges cytosolicADP for mitochondrially synthesized ATP; expressed underanaerobic conditions; similar to Pet9p and Aac1p; hasroles in maintenance of viability and in respiration
LALA0_S09e03334g	weakly similar to uniprot|P38200 Saccharomyces cerevisiae YBL031W SHE1 Mitotic spindle protein that interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure
LALA0_S09e03356g	similar to uniprot|P38199 Saccharomyces cerevisiae YBL032W HEK2 RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
LALA0_S09e03378g	similar to uniprot|P38066 Saccharomyces cerevisiae YBL033C RIB1 GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
LALA0_S09e03400g	similar to uniprot|O43137 Saccharomyces cerevisiae YBR085C-A Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
LALA0_S09e03422g	weakly similar to uniprot|P38198 Saccharomyces cerevisiae YBL034C STU1 Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
LALA0_S09e03444g	similar to uniprot|P38121 Saccharomyces cerevisiae YBL035C POL12 B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
LALA0_S09e03466g	weakly similar to uniprot|P38250 Saccharomyces cerevisiae YBR086C IST2 Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
LALA0_S09e03488g	similar to uniprot|P38197 Saccharomyces cerevisiae YBL036C Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
LALA0_S09e03510g	similar to uniprot|P38065 Saccharomyces cerevisiae YBL037W APL3 Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport
LALA0_S09e03532g	highly similar to uniprot|P38251 Saccharomyces cerevisiae YBR087W RFC5 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
LALA0_S09e03554g	similar to uniprot|P38064 Saccharomyces cerevisiae YBL038W MRPL16 Mitochondrial ribosomal protein of the large subunit
LALA0_S09e03576g	similar to uniprot|P08425 Saccharomyces cerevisiae YPR047W MSF1 Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase
LALA0_S09e03598g	similar to uniprot|Q12181 Saccharomyces cerevisiae YPR048W TAH18 Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress
LALA0_S09e03620g	similar to uniprot|Q12527 Saccharomyces cerevisiae YPR049C ATG11 Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)
LALA0_S09e03642g	similar to uniprot|Q03503 Saccharomyces cerevisiae YPR051W MAK3 Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
LALA0_S09e03664g	highly similar to uniprot|P15873 Saccharomyces cerevisiae YBR088C POL30 Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
LALA0_S09e03686g	highly similar to uniprot|P11633 Saccharomyces cerevisiae YBR089C-A (ohnolog of YPR052C) NHP6B High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2
LALA0_S09e03708g	similar to uniprot|P32830 Saccharomyces cerevisiae YBR091C TIM12 Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
LALA0_S09e03730g	similar to uniprot|P38254 Saccharomyces cerevisiae YBR094W PBY1 Putative tubulin tyrosine ligase associated with P-bodies
LALA0_S09e03752g	similar to uniprot|P38255 Saccharomyces cerevisiae YBR095C RXT2 Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth
LALA0_S09e03774g	similar to uniprot|P38256 Saccharomyces cerevisiae YBR096W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER
LALA0_S09e03796g	similar to uniprot|P41808 Saccharomyces cerevisiae YPR054W SMK1 Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
LALA0_S09e03818g	similar to uniprot|P22219 Saccharomyces cerevisiae YBR097W VPS15 Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p
LALA0_S09e03840g	similar to uniprot|P32855 Saccharomyces cerevisiae YPR055W SEC8 Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
LALA0_S09e03862g	weakly similar to uniprot|P38257 Saccharomyces cerevisiae YBR098W MMS4 Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination
LALA0_S09e03884g	similar to uniprot|P38260 Saccharomyces cerevisiae YBR101C FES1 Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
LALA0_S09e03906g	similar to uniprot|P38261 Saccharomyces cerevisiae YBR102C EXO84 Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis
LALA0_S09e03928g	similar to uniprot|P38262 Saccharomyces cerevisiae YBR103W SIF2 WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
LALA0_S09e03950g	highly similar to uniprot|Q12004 Saccharomyces cerevisiae YPR056W TFB4 Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p
LALA0_S09e03972g	weakly similar to uniprot|Q99177 Saccharomyces cerevisiae YPR057W BRR1 snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed
LALA0_S09e03994g	similar to uniprot|P47148 Saccharomyces cerevisiae YJR111C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
LALA0_S09e04016g	similar to uniprot|P47147 Saccharomyces cerevisiae YJR110W YMR1 Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family
LALA0_S09e04038g	similar to uniprot|P38191 Saccharomyces cerevisiae YBL049W MOH1 Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase
LALA0_S09e04060g	weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
LALA0_S09e04082g	similar to uniprot|P32602 Saccharomyces cerevisiae YBL050W SEC17 Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
LALA0_S09e04104g	weakly similar to uniprot|Q08905 Saccharomyces cerevisiae YOR381W Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
LALA0_S09e04126g	similar to uniprot|P40897 Saccharomyces cerevisiae YJL212C OPT1 Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
LALA0_S09e04148g	highly similar to uniprot|P03965 Saccharomyces cerevisiae YJR109C CPA2 Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
LALA0_S09e04170g	some similarities with uniprot|Q12300 Saccharomyces cerevisiae YDL138W (ohnolog of YDL194W) RGT2 Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p
LALA0_S09e04192g	similar to uniprot|P10823 Saccharomyces cerevisiae YER020W GPA2 Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
LALA0_S09e04214g	similar to uniprot|P47145 Saccharomyces cerevisiae YJR107W Putative protein of unknown function; has sequence or structural similarity to lipases
LALA0_S09e04236g	similar to uniprot|P47144 Saccharomyces cerevisiae YJR106W ECM27 Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
LALA0_S09e04258g	highly similar to uniprot|P47143 Saccharomyces cerevisiae YJR105W ADO1 Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
LALA0_S09e04280g	similar to uniprot|P47153 Saccharomyces cerevisiae YJR116W TDA4 Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
LALA0_S09e04302g	similar to uniprot|P47154 Saccharomyces cerevisiae YJR117W STE24 Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
LALA0_S09e04324g	weakly similar to uniprot|P36166 Saccharomyces cerevisiae YKR090W PXL1 LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin
LALA0_S09e04346g	weakly similar to uniprot|Q12416 Saccharomyces cerevisiae YOR083W (ohnolog of YKR091W) WHI5 Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
LALA0_S09e04368g	similar to uniprot|Q12405 Saccharomyces cerevisiae YOR084W LPX1 Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
LALA0_S09e04390g	similar to uniprot|C5DH34 Lachancea thermotolerans KLTH0E01012g hypothetical protein
LALA0_S09e04412g	highly similar to uniprot|Q00578 Saccharomyces cerevisiae YIL143C SSL2 Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3
LALA0_S09e04434g	similar to uniprot|P40460 Saccharomyces cerevisiae YIL144W TID3 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
LALA0_S09e04456g	similar to uniprot|P40459 Saccharomyces cerevisiae YIL145C PAN6 Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
LALA0_S09e04478g	similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
LALA0_S09e04500g	weakly similar to uniprot|P40458 Saccharomyces cerevisiae YIL146C ATG32 Mitochondrial-anchored transmembrane receptor that interacts with the autophagy adaptor protein, Atg11p, and is essential for mitophagy, the selective vacuolar degradation of mitochondria in response to starvation
LALA0_S09e04522g	similar to uniprot|P39928 Saccharomyces cerevisiae YIL147C SLN1 Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
LALA0_S09e04544g	some similarities with uniprot|P0CH08 Saccharomyces cerevisiae YIL148W (ohnolog of YKR094C) RPL40A Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
LALA0_S09e04566g	similar to uniprot|P40457 Saccharomyces cerevisiae YIL149C (ohnolog of YKR095W) MLP2 Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
LALA0_S09e04588g	similar to uniprot|P32354 Saccharomyces cerevisiae YIL150C MCM10 Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins
LALA0_S09e04610g	similar to uniprot|C5DH31 Lachancea thermotolerans KLTH0E00946g hypothetical protein
LALA0_S09e04632g	similar to uniprot|Q3E833 Saccharomyces cerevisiae YKR095W-A PCC1 Component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
LALA0_S09e04654g	similar to uniprot|P40456 Saccharomyces cerevisiae YIL151C (ohnolog of YKR096W) Putative protein of unknown function, predicted to contain a PINc domain
LALA0_S09e04676g	similar to uniprot|G8BPP0 Tetrapisispora phaffii TPHA0B02990 hypothetical protein
LALA0_S09e04698g	similar to uniprot|P34167 Saccharomyces cerevisiae YPR163C TIF3 Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
LALA0_S09e04720g	similar to uniprot|Q06179 Saccharomyces cerevisiae YLR454W FMP27 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S09e04742g	highly similar to uniprot|P24783 Saccharomyces cerevisiae YNL112W DBP2 Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing
LALA0_S09e04764g	similar to uniprot|Q12453 Saccharomyces cerevisiae YOR112W CEX1 Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p
LALA0_S09e04786g	similar to uniprot|P40312 Saccharomyces cerevisiae YNL111C CYB5 Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
LALA0_S09e04808g	similar to uniprot|P53927 Saccharomyces cerevisiae YNL110C NOP15 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
LALA0_S09e04830g	similar to uniprot|Q99210 Saccharomyces cerevisiae YOR111W Putative protein of unknown function
LALA0_S09e04852g	similar to uniprot|Q6B220 Saccharomyces cerevisiae YOR110W (ohnolog of YNL108C) TFC7 One of six subunits ofthe RNA polymerase III transcription initiation factorcomplex (TFIIIC); part of the TauA globular domain ofTFIIIC that binds DNA at the BoxA promoter sites of tRNAand similar genes
LALA0_S09e04874g	similar to uniprot|P53930 Saccharomyces cerevisiae YNL107W YAF9 Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
LALA0_S09e04896g	similar to uniprot|Q12271 Saccharomyces cerevisiae YOR109W (ohnolog of YNL106C) INP53 Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
LALA0_S09e04918g	highly similar to uniprot|Q12166 Saccharomyces cerevisiae YOR108W (ohnolog of YNL104C) LEU9 Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
LALA0_S09e04940g	weakly similar to uniprot|Q99188 Saccharomyces cerevisiae YOR107W RGS2 Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
LALA0_S09e04962g	weakly similar to uniprot|P32389 Saccharomyces cerevisiae YNL103W MET4 Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
LALA0_S09e04984g	similar to uniprot|Q12241 Saccharomyces cerevisiae YOR106W VAM3 Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region
LALA0_S09e05006g	similar to uniprot|P13382 Saccharomyces cerevisiae YNL102W POL1 Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
LALA0_S09e05028g	highly similar to uniprot|Q12178 Saccharomyces cerevisiae YPR062W FCY1 Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
LALA0_S09e05050g	similar to uniprot|P50944 Saccharomyces cerevisiae YNL101W AVT4 Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
LALA0_S09e05072g	similar to uniprot|P50945 Saccharomyces cerevisiae YNL100W AIM37 Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays reduced respiratory growth and reduced frequency of mitochondrial genome loss
LALA0_S09e05094g	some similarities with uniprot|G8ZQA3 Torulaspora delbrueckii TDEL_0B06680 hypothetical protein
LALA0_S09e05116g	similar to uniprot|P50946 Saccharomyces cerevisiae YNL099C OCA1 Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
LALA0_S09e05138g	similar to uniprot|P46964 Saccharomyces cerevisiae YOR103C OST2 Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
LALA0_S09e05160g	similar to uniprot|P01119 Saccharomyces cerevisiae YOR101W (ohnolog of YNL098C) RAS1 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
LALA0_S09e05182g	similar to uniprot|P50947 Saccharomyces cerevisiae YNL097C PHO23 Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
LALA0_S09e05226g	similar to uniprot|Q04210 Saccharomyces cerevisiae YMR040W (ohnolog of YKL065C) YET2 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
LALA0_S09e05248g	similar to uniprot|Q04212 Saccharomyces cerevisiae YMR041C ARA2 NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
LALA0_S09e05270g	similar to uniprot|P54000 Saccharomyces cerevisiae YMR039C SUB1 Transcriptional coactivator, facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes
LALA0_S09e05292g	similar to uniprot|P35724 Saccharomyces cerevisiae YKL064W MNR2 Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
LALA0_S09e05314g	similar to uniprot|P40202 Saccharomyces cerevisiae YMR038C CCS1 Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
LALA0_S09e05336g	some similarities with uniprot|P35725 Saccharomyces cerevisiae YKL063C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
LALA0_S09e05358g	weakly similar to uniprot|P33748 Saccharomyces cerevisiae YMR037C (ohnolog of YKL062W) MSN2 Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
LALA0_S09e05380g	similar to uniprot|P32801 Saccharomyces cerevisiae YKL048C ELM1 Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
LALA0_S09e05402g	weakly similar to uniprot|P23748 Saccharomyces cerevisiae YMR036C MIH1 Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
LALA0_S09e05424g	similar to uniprot|P46972 Saccharomyces cerevisiae YMR035W IMP2 Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
LALA0_S09e05446g	similar to uniprot|Q05123 Saccharomyces cerevisiae YMR033W ARP9 Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
LALA0_S09e05468g	similar to uniprot|P36012 Saccharomyces cerevisiae YKL049C CSE4 Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p
LALA0_S09e05490g	similar to uniprot|Q05080 Saccharomyces cerevisiae YMR032W HOF1 Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
LALA0_S09e05512g	weakly similar to uniprot|Q05050 Saccharomyces cerevisiae YMR031C (ohnolog of YKL050C) EIS1 Component of the eisosome that is required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
LALA0_S09e05534g	similar to uniprot|P35735 Saccharomyces cerevisiae YKL051W SFK1 Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
LALA0_S09e05556g	similar to uniprot|P35734 Saccharomyces cerevisiae YKL052C ASK1 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
LALA0_S09e05578g	highly similar to uniprot|O60200 Saccharomyces cerevisiae YKL053C-A MDM35 Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs
LALA0_S09e05600g	weakly similar to uniprot|P35732 Saccharomyces cerevisiae YKL054C DEF1 RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis
LALA0_S09e05622g	similar to uniprot|P35731 Saccharomyces cerevisiae YKL055C OAR1 Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p
LALA0_S09e05644g	highly similar to uniprot|P35691 Saccharomyces cerevisiae YKL056C TMA19 Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
LALA0_S09e05666g	weakly similar to uniprot|Q05040 Saccharomyces cerevisiae YMR029C FAR8 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
LALA0_S09e05688g	similar to uniprot|P35729 Saccharomyces cerevisiae YKL057C NUP120 Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; the Nup84 subcomplex has a role in transcription elongation
LALA0_S09e05710g	similar to uniprot|Q04372 Saccharomyces cerevisiae YMR028W TAP42 Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits
LALA0_S09e05732g	similar to uniprot|P32774 Saccharomyces cerevisiae YKL058W TOA2 TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA
LALA0_S09e05754g	similar to uniprot|P35728 Saccharomyces cerevisiae YKL059C MPE1 Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
LALA0_S09e05776g	similar to uniprot|Q04371 Saccharomyces cerevisiae YMR027W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene
LALA0_S09e05798g	highly similar to uniprot|P14540 Saccharomyces cerevisiae YKL060C FBA1 Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
LALA0_S09e05820g	weakly similar to uniprot|Q6CRU7 Kluyveromyces lactis hypothetical protein
LALA0_S09e05842g	similar to uniprot|G8ZQA3 Torulaspora delbrueckii TDEL_0B06680 hypothetical protein
LALA0_S09e05864g	weakly similar to uniprot|G8JP94 Eremothecium cymbalariae Ecym_2420 hypothetical protein
LALA0_S09e05886g	some similarities with uniprot|P02309 Saccharomyces cerevisiae YNL030W HHF2 Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
LALA0_S09e05908g	some similarities with uniprot|P02303 Saccharomyces cerevisiae YNL031C HHT2 Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
LALA0_S09e05930g	similar to uniprot|P00912 Saccharomyces cerevisiae YDR007W TRP1 Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
LALA0_S09e05952g	highly similar to uniprot|P00817 Saccharomyces cerevisiae YBR011C IPP1 Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
LALA0_S09e05974g	weakly similar to uniprot|Q03446 Saccharomyces cerevisiae YDR003W (ohnolog of YBR005W) RCR2 Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p
LALA0_S09e05996g	similar to uniprot|P38211 Saccharomyces cerevisiae YBR004C GPI18 Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
LALA0_S09e06018g	highly similar to uniprot|P18900 Saccharomyces cerevisiae YBR003W COQ1 Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
LALA0_S09e06040g	similar to uniprot|P35196 Saccharomyces cerevisiae YBR002C RER2 Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting
LALA0_S09e06062g	highly similar to uniprot|P41920 Saccharomyces cerevisiae YDR002W YRB1 Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
LALA0_S09e06084g	highly similar to uniprot|P32356 Saccharomyces cerevisiae YDR001C (ohnolog of YBR001C) NTH1 Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p
LALA0_S09e06128g	highly similar to uniprot|P35195 Saccharomyces cerevisiae YBL001C ECM15 Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
LALA0_S09e06150g	highly similar to uniprot|P02293 Saccharomyces cerevisiae YDR224C HTB1 Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
LALA0_S09e06172g	highly similar to uniprot|P04911 Saccharomyces cerevisiae YDR225W HTA1 Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
LALA0_S09e06194g	highly similar to uniprot|Q05210 Saccharomyces cerevisiae YDL001W RMD1 Cytoplasmic protein required for sporulation
LALA0_S09e06216g	similar to uniprot|Q03435 Saccharomyces cerevisiae YDL002C NHP10 Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
LALA0_S09e06238g	similar to uniprot|P35194 Saccharomyces cerevisiae YBL004W UTP20 Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
LALA0_S09e06260g	similar to uniprot|Q05325 Saccharomyces cerevisiae YDL003W MCD1 Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
LALA0_S09e06282g	highly similar to uniprot|Q12165 Saccharomyces cerevisiae YDL004W ATP16 Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
LALA0_S09e06304g	some similarities with uniprot|Q12124 Saccharomyces cerevisiae YDL005C MED2 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
LALA0_S09e06326g	highly similar to uniprot|P35182 Saccharomyces cerevisiae YDL006W PTC1 Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation
LALA0_S09e06348g	highly similar to uniprot|P40327 Saccharomyces cerevisiae YDL007W RPT2 One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
LALA0_S09e06392g	similar to uniprot|P53394 Saccharomyces cerevisiae YPR003C Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene
LALA0_S09e06414g	similar to uniprot|Q12480 Saccharomyces cerevisiae YPR004C AIM45 Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response
LALA0_S09e06436g	similar to uniprot|P43591 Saccharomyces cerevisiae YFR007W YFH7 Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
LALA0_S09e06458g	weakly similar to uniprot|Q12188 Saccharomyces cerevisiae YPR007C REC8 Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
LALA0_S09e06480g	similar to uniprot|P43592 Saccharomyces cerevisiae YFR008W FAR7 Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p
LALA0_S09e06524g	highly similar to uniprot|P40088 Saccharomyces cerevisiae YER145C FTR1 High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron
LALA0_S09e06546g	weakly similar to uniprot|P15315 Saccharomyces cerevisiae YGL166W (ohnolog of YPR008W) CUP2 Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations
LALA0_S09e06568g	similar to uniprot|P53107 Saccharomyces cerevisiae YGL164C YRB30 RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
LALA0_S09e06590g	similar to uniprot|P32863 Saccharomyces cerevisiae YGL163C RAD54 DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
LALA0_S09e06612g	weakly similar to uniprot|P53032 Saccharomyces cerevisiae YGL162W (ohnolog of YPR009W) SUT1 Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
LALA0_S09e06634g	weakly similar to uniprot|P53108 Saccharomyces cerevisiae YGL161C YIP5 Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
LALA0_S09e06678g	similar to uniprot|P32579 Saccharomyces cerevisiae YGL169W SUA5 Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family
LALA0_S09e06700g	highly similar to uniprot|P13586 Saccharomyces cerevisiae YGL167C PMR1 High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
LALA0_S09e06722g	highly similar to uniprot|P22138 Saccharomyces cerevisiae YPR010C RPA135 RNA polymerase I second largest subunit A135
LALA0_S09e06766g	similar to uniprot|P53334 Saccharomyces cerevisiae YGR279C (ohnolog of YMR305C) SCW4 Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
LALA0_S09e06788g	similar to uniprot|P53214 Saccharomyces cerevisiae YGR023W (ohnolog of YLR332W) MTL1 Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p
LALA0_S09e06832g	similar to uniprot|C5DNI6 Lachancea thermotolerans KLTH0G17358g hypothetical protein
LALA0_S09e06854g	highly similar to uniprot|P53215 Saccharomyces cerevisiae YGR024C THG1 tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
LALA0_S09e06876g	highly similar to uniprot|P06168 Saccharomyces cerevisiae YLR355C ILV5 Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
LALA0_S09e06898g	some similarities with uniprot|P32338 Saccharomyces cerevisiae YGR044C RME1 Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation
LALA0_S09e06920g	similar to uniprot|C5DG58 Lachancea thermotolerans KLTH0D02596g hypothetical protein
LALA0_S09e06942g	similar to uniprot|P02400 Saccharomyces cerevisiae YDR382W RPP2B Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
LALA0_S09e06964g	highly similar to uniprot|Q01855 Saccharomyces cerevisiae YOL040C RPS15 Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
LALA0_S09e06986g	some similarities with uniprot|P31385 Saccharomyces cerevisiae YAL013W DEP1 Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation
LALA0_S09e07008g	similar to uniprot|Q08208 Saccharomyces cerevisiae YOL041C NOP12 Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p
LALA0_S09e07030g	similar to uniprot|P31377 Saccharomyces cerevisiae YAL014C SYN8 Endosomal SNARE related to mammalian syntaxin 8
LALA0_S09e07052g	weakly similar to uniprot|C5DG58 Lachancea thermotolerans KLTH0D02596g hypothetical protein
LALA0_S09e07074g	similar to uniprot|Q08213 Saccharomyces cerevisiae YOL042W NGL1 Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S09e07096g	similar to uniprot|P31378 Saccharomyces cerevisiae YAL015C (ohnolog of YOL043C) NTG1 DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress
LALA0_S09e07118g	highly similar to uniprot|P31383 Saccharomyces cerevisiae YAL016W TPD3 Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A), which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III
LALA0_S09e07140g	weakly similar to uniprot|Q08215 Saccharomyces cerevisiae YOL044W PEX15 Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly
LALA0_S09e07162g	similar to uniprot|P31374 Saccharomyces cerevisiae YAL017W (ohnolog of YOL045W) PSK1 One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status
LALA0_S09e07184g	similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C (ohnolog of YOL048C) Putative protein of unknown function
LALA0_S09e07206g	weakly similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C (ohnolog of YOL048C) Putative protein of unknown function
LALA0_S09e07228g	weakly similar to uniprot|P31379 Saccharomyces cerevisiae YAL018C (ohnolog of YOL048C) Putative protein of unknown function
LALA0_S09e07250g	similar to uniprot|Q08220 Saccharomyces cerevisiae YOL049W GSH2 Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
LALA0_S09e07272g	weakly similar to uniprot|P19659 Saccharomyces cerevisiae YOL051W GAL11 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
LALA0_S09e07294g	similar to uniprot|P31380 Saccharomyces cerevisiae YAL019W FUN30 Conserved member of the Snf2p family with ATP-dependent chromatin remodeling activity; has a role in silencing; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
LALA0_S09e07316g	weakly similar to uniprot|P31386 Saccharomyces cerevisiae YAL020C ATS1 Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
LALA0_S09e07338g	weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W (ohnolog of YOR363C) OAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
LALA0_S09e07360g	similar to uniprot|Q12502 Saccharomyces cerevisiae YOR322C LDB19 Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dye
LALA0_S09e07382g	highly similar to uniprot|P31382 Saccharomyces cerevisiae YAL023C (ohnolog of YOR321W) PMT2 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein Ser/Thr residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5; target for new antifungal
LALA0_S09e07404g	similar to uniprot|P31381 Saccharomyces cerevisiae YAL022C FUN26 Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis
LALA0_S09e07426g	similar to uniprot|P31384 Saccharomyces cerevisiae YAL021C CCR4 Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
LALA0_S09e07448g	highly similar to uniprot|P31109 Saccharomyces cerevisiae YAL030W (ohnolog of YOR327C) SNC1 Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
LALA0_S09e07470g	similar to uniprot|P32492 Saccharomyces cerevisiae YAL029C (ohnolog of YOR326W) MYO4 One of two type V myosinmotors (along with MYO2) involved in actin-based transportof cargos; required for mRNA transport, including ASH1mRNA, and facilitating the growth and movement of ERtubules into the growing bud along with She3p
LALA0_S10e00100g	some similarities with uniprot|P39712 Saccharomyces cerevisiae YAL063C FLO9 Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
LALA0_S10e00122g	highly similar to uniprot|Q12235 Saccharomyces cerevisiae YLL055W YCT1 High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
LALA0_S10e00144g	similar to uniprot|P40892 Saccharomyces cerevisiae YJL218W Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
LALA0_S10e00166g	highly similar to uniprot|P28272 Saccharomyces cerevisiae YKL216W URA1 Dihydroorotate dehydrogenase,catalyzes the fourth enzymatic step in the de novobiosynthesis of pyrimidines, converting dihydroorotic acidinto orotic acid
LALA0_S10e00188g	similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S10e00210g	similar to uniprot|Q12512 Saccharomyces cerevisiae YOL154W ZPS1 Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
LALA0_S10e00232g	some similarities with uniprot|Q751S6 Ashbya gossypii AGL345Wp hypothetical protein
LALA0_S10e00254g	weakly similar to uniprot|C5DEV0 Lachancea thermotolerans KLTH0D09966g hypothetical protein
LALA0_S10e00276g	similar to uniprot|P32497 Saccharomyces cerevisiae YMR309C NIP1 eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
LALA0_S10e00298g	highly similar to uniprot|P15703 Saccharomyces cerevisiae YGR282C BGL2 Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance
LALA0_S10e00320g	similar to uniprot|P53336 Saccharomyces cerevisiae YGR283C (ohnolog of YMR310C) Protein of unknown function; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus
LALA0_S10e00342g	similar to uniprot|P41818 Saccharomyces cerevisiae YMR311C GLC8 Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
LALA0_S10e00364g	highly similar to uniprot|P53337 Saccharomyces cerevisiae YGR284C ERV29 Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo
LALA0_S10e00386g	highly similar to uniprot|P32527 Saccharomyces cerevisiae YGR285C ZUO1 Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
LALA0_S10e00408g	similar to uniprot|Q04868 Saccharomyces cerevisiae YMR312W ELP6 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
LALA0_S10e00430g	similar to uniprot|P40308 Saccharomyces cerevisiae YMR313C TGL3 Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation
LALA0_S10e00452g	highly similar to uniprot|P40302 Saccharomyces cerevisiae YMR314W PRE5 Alpha 6 subunit of the 20S proteasome
LALA0_S10e00474g	highly similar to uniprot|P40416 Saccharomyces cerevisiae YMR301C ATM1 Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
LALA0_S10e00496g	highly similar to uniprot|P04046 Saccharomyces cerevisiae YMR300C ADE4 Phosphoribosylpyrophosphateamidotransferase (PRPPAT; amidophosphoribosyltransferase),catalyzes first step of the 'de novo' purine nucleotidebiosynthetic pathway
LALA0_S10e00518g	weakly similar to uniprot|Q04949 Saccharomyces cerevisiae YMR299C DYN3 Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
LALA0_S10e00540g	similar to uniprot|P53331 Saccharomyces cerevisiae YGR276C RNH70 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts
LALA0_S10e00562g	weakly similar to uniprot|P53330 Saccharomyces cerevisiae YGR275W RTT102 Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition
LALA0_S10e00584g	similar to uniprot|P46677 Saccharomyces cerevisiae YGR274C TAF1 TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
LALA0_S10e00606g	similar to uniprot|Q03579 Saccharomyces cerevisiae YMR298W LIP1 Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis
LALA0_S10e00628g	similar to uniprot|P00729 Saccharomyces cerevisiae YMR297W PRC1 Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
LALA0_S10e00650g	similar to uniprot|P25045 Saccharomyces cerevisiae YMR296C LCB1 Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
LALA0_S10e00672g	weakly similar to uniprot|P53047 Saccharomyces cerevisiae YGR213C (ohnolog of YLR046C) RTA1 Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
LALA0_S10e00694g	similar to uniprot|P53329 Saccharomyces cerevisiae YGR273C (ohnolog of YMR295C) Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene
LALA0_S10e00716g	similar to uniprot|Q3E705 Saccharomyces cerevisiae YGR271C-A EFG1 Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
LALA0_S10e00738g	highly similar to uniprot|P53327 Saccharomyces cerevisiae YGR271W SLH1 Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses
LALA0_S10e00760g	weakly similar to uniprot|P36224 Saccharomyces cerevisiae YMR294W JNM1 Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
LALA0_S10e00782g	similar to uniprot|Q03557 Saccharomyces cerevisiae YMR293C HER2 Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
LALA0_S10e00804g	similar to uniprot|P40340 Saccharomyces cerevisiae YGR270W YTA7 Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p
LALA0_S10e00826g	highly similar to uniprot|Q03554 Saccharomyces cerevisiae YMR292W GOT1 Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition
LALA0_S10e00848g	similar to uniprot|P40325 Saccharomyces cerevisiae YGR268C HUA1 Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
LALA0_S10e00870g	highly similar to uniprot|P51601 Saccharomyces cerevisiae YGR267C FOL2 GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
LALA0_S10e00892g	similar to uniprot|Q03533 Saccharomyces cerevisiae YMR291W TDA1 Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene
LALA0_S10e00914g	similar to uniprot|P53326 Saccharomyces cerevisiae YGR266W Protein of unknown function, predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane
LALA0_S10e00936g	highly similar to uniprot|Q03532 Saccharomyces cerevisiae YMR290C HAS1 ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
LALA0_S10e00958g	highly similar to uniprot|P00958 Saccharomyces cerevisiae YGR264C MES1 Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
LALA0_S10e00980g	highly similar to uniprot|P53323 Saccharomyces cerevisiae YGR262C BUD32 Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription
LALA0_S10e01002g	similar to uniprot|Q03266 Saccharomyces cerevisiae YMR289W ABZ2 Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
LALA0_S10e01046g	similar to uniprot|P46682 Saccharomyces cerevisiae YGR261C APL6 Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
LALA0_S10e01068g	similar to uniprot|P49955 Saccharomyces cerevisiae YMR288W HSH155 U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
LALA0_S10e01090g	similar to uniprot|P38875 Saccharomyces cerevisiae YHR188C GPI16 Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
LALA0_S10e01112g	similar to uniprot|P38874 Saccharomyces cerevisiae YHR187W IKI1 Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
LALA0_S10e01134g	similar to uniprot|P38873 Saccharomyces cerevisiae YHR186C KOG1 Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
LALA0_S10e01178g	similar to uniprot|P07276 Saccharomyces cerevisiae YGR258C RAD2 Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
LALA0_S10e01200g	weakly similar to uniprot|P38872 Saccharomyces cerevisiae YHR185C PFS1 Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation
LALA0_S10e01222g	similar to uniprot|P53320 Saccharomyces cerevisiae YGR257C MTM1 Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
LALA0_S10e01244g	weakly similar to uniprot|P38871 Saccharomyces cerevisiae YHR184W SSP1 Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis
LALA0_S10e01266g	highly similar to uniprot|P38720 Saccharomyces cerevisiae YHR183W (ohnolog of YGR256W) GND1 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
LALA0_S10e01288g	similar to uniprot|Q04705 Saccharomyces cerevisiae YML047C (ohnolog of YJR054W) PRM6 Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating
LALA0_S10e01310g	weakly similar to uniprot|P47113 Saccharomyces cerevisiae YJR053W BFA1 Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis
LALA0_S10e01332g	similar to uniprot|P39682 Saccharomyces cerevisiae YML046W PRP39 U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
LALA0_S10e01354g	similar to uniprot|P06779 Saccharomyces cerevisiae YJR052W RAD7 Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
LALA0_S10e01398g	weakly similar to uniprot|O00022 Saccharomyces cerevisiae YOR059C Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor RPN4
LALA0_S10e01420g	similar to uniprot|P32613 Saccharomyces cerevisiae YEL048C TCA17 Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder
LALA0_S10e01442g	similar to uniprot|P32614 Saccharomyces cerevisiae YEL047C (ohnolog of YJR051W) Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
LALA0_S10e01464g	highly similar to uniprot|P37303 Saccharomyces cerevisiae YEL046C GLY1 Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
LALA0_S10e01508g	similar to uniprot|P32617 Saccharomyces cerevisiae YEL044W IES6 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes
LALA0_S10e01530g	weakly similar to uniprot|P32618 Saccharomyces cerevisiae YEL043W Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold
LALA0_S10e01552g	similar to uniprot|P21374 Saccharomyces cerevisiae YJR050W ISY1 Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
LALA0_S10e01574g	weakly similar to uniprot|Q06211 Saccharomyces cerevisiae YPR164W MMS1 Subunit of an E3 ubiquitin ligase complex involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay
LALA0_S10e01596g	similar to uniprot|Q12283 Saccharomyces cerevisiae YOR221C MCT1 Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling
LALA0_S10e01618g	similar to uniprot|P19541 Saccharomyces cerevisiae YPL133C RDS2 Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole
LALA0_S10e01640g	similar to uniprot|P19516 Saccharomyces cerevisiae YPL132W COX11 Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
LALA0_S10e01662g	similar to uniprot|Q12044 Saccharomyces cerevisiae YOR220W RCN2 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; phosphorylated in response to alpha factor
LALA0_S10e01684g	highly similar to uniprot|P26321 Saccharomyces cerevisiae YPL131W RPL5 Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
LALA0_S10e01706g	similar to uniprot|P33894 Saccharomyces cerevisiae YOR219C STE13 Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
LALA0_S10e01728g	similar to uniprot|P38630 Saccharomyces cerevisiae YOR217W RFC1 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
LALA0_S10e01750g	similar to uniprot|Q12234 Saccharomyces cerevisiae YOR216C RUD3 Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
LALA0_S10e01772g	similar to uniprot|Q12032 Saccharomyces cerevisiae YOR215C AIM41 Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
LALA0_S10e01794g	highly similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W (ohnolog of YOR213C) TAF14 Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
LALA0_S10e01816g	weakly similar to uniprot|P35189 Saccharomyces cerevisiae YPL129W (ohnolog of YOR213C) TAF14 Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain
LALA0_S10e01838g	similar to uniprot|P18851 Saccharomyces cerevisiae YOR212W STE4 G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
LALA0_S10e01860g	weakly similar to uniprot|Q02457 Saccharomyces cerevisiae YPL128C TBF1 Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression
LALA0_S10e01882g	weakly similar to uniprot|P53551 Saccharomyces cerevisiae YPL127C HHO1 Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation
LALA0_S10e01904g	similar to uniprot|P32266 Saccharomyces cerevisiae YOR211C MGM1 Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy
LALA0_S10e01926g	some similarities with uniprot|P22139 Saccharomyces cerevisiae YOR210W RPB10 RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
LALA0_S10e01948g	similar to uniprot|Q02931 Saccharomyces cerevisiae YPL126W NAN1 U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA
LALA0_S10e01970g	similar to uniprot|P39683 Saccharomyces cerevisiae YOR209C NPT1 Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
LALA0_S10e01992g	similar to uniprot|Q02932 Saccharomyces cerevisiae YPL125W KAP120 Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p
LALA0_S10e02014g	weakly similar to uniprot|P29461 Saccharomyces cerevisiae YOR208W PTP2 Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
LALA0_S10e02036g	similar to uniprot|C5DGZ6 Lachancea thermotolerans KLTH0D09570g hypothetical protein
LALA0_S10e02058g	similar to uniprot|Q02933 Saccharomyces cerevisiae YPL123C RNY1 Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
LALA0_S10e02080g	similar to uniprot|P21672 Saccharomyces cerevisiae YIL066C (ohnolog of YER070W) RNR3 Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
LALA0_S10e02102g	similar to uniprot|Q02948 Saccharomyces cerevisiae YPL120W VPS30 Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential inautophagy and Complex II is required for vacuolar proteinsorting; ortholog of the higher eukaryotic gene Beclin 1
LALA0_S10e02124g	similar to uniprot|Q08622 Saccharomyces cerevisiae YOR205C GEP3 Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
LALA0_S10e02146g	highly similar to uniprot|P39744 Saccharomyces cerevisiae YOR206W NOC2 Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
LALA0_S10e02168g	similar to uniprot|P32489 Saccharomyces cerevisiae YPL121C MEI5 Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
LALA0_S10e02190g	highly similar to uniprot|P22276 Saccharomyces cerevisiae YOR207C RET1 Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
LALA0_S10e02212g	highly similar to uniprot|P87331 Saccharomyces cerevisiae YPL122C TFB2 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
LALA0_S10e02256g	similar to uniprot|P24784 Saccharomyces cerevisiae YPL119C (ohnolog of YOR204W) DBP1 Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
LALA0_S10e02278g	similar to uniprot|Q02950 Saccharomyces cerevisiae YPL118W MRP51 Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
LALA0_S10e02300g	highly similar to uniprot|P06633 Saccharomyces cerevisiae YOR202W HIS3 Imidazoleglycerol-phosphatedehydratase, catalyzes the sixth step in histidinebiosynthesis; mutations cause histidine auxotrophy andsensitivity to Cu, Co, and Ni salts; transcription isregulated by general amino acid control via Gcn4p
LALA0_S10e02322g	similar to uniprot|P25270 Saccharomyces cerevisiae YOR201C MRM1 Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA
LALA0_S10e02344g	highly similar to uniprot|P15496 Saccharomyces cerevisiae YPL117C IDI1 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
LALA0_S10e02366g	similar to uniprot|P38934 Saccharomyces cerevisiae YOR198C BFR1 Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
LALA0_S10e02388g	similar to uniprot|Q08601 Saccharomyces cerevisiae YOR197W MCA1 Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon H2O2 treatment; contributes to clearance of insoluble protein aggregates during normal growth; may be involved in cell cycle progression
LALA0_S10e02410g	similar to uniprot|Q02959 Saccharomyces cerevisiae YPL116W HOS3 Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
LALA0_S10e02432g	highly similar to uniprot|C5E2X3 Lachancea thermotolerans KLTH0H08492g hypothetical protein
LALA0_S10e02454g	similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin
LALA0_S10e02476g	similar to uniprot|P32875 Saccharomyces cerevisiae YOR196C LIP5 Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
LALA0_S10e02498g	similar to uniprot|P32873 Saccharomyces cerevisiae YPL115C BEM3 Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
LALA0_S10e02520g	weakly similar to uniprot|Q08581 Saccharomyces cerevisiae YOR195W SLK19 Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
LALA0_S10e02542g	similar to uniprot|P32773 Saccharomyces cerevisiae YOR194C TOA1 TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
LALA0_S10e02564g	similar to uniprot|Q02961 Saccharomyces cerevisiae YPL113C Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
LALA0_S10e02586g	similar to uniprot|Q08580 Saccharomyces cerevisiae YOR193W (ohnolog of YPL112C) PEX27 Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
LALA0_S10e02630g	highly similar to uniprot|P32316 Saccharomyces cerevisiae YBL015W ACH1 Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
LALA0_S10e02674g	highly similar to uniprot|P40081 Saccharomyces cerevisiae YER134C Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene
LALA0_S10e02784g	highly similar to uniprot|P10592 Saccharomyces cerevisiae YLL024C SSA2 ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
LALA0_S10e02806g	similar to uniprot|Q12164 Saccharomyces cerevisiae YLL023C POM33 Transmembrane nucleoporin involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p
LALA0_S10e02828g	similar to uniprot|C5E2Y7 Lachancea thermotolerans KLTH0H08888g hypothetical protein
LALA0_S10e02850g	similar to uniprot|P32457 Saccharomyces cerevisiae YLR314C CDC3 Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
LALA0_S10e02872g	weakly similar to uniprot|P38995 Saccharomyces cerevisiae YDR270W CCC2 Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases
LALA0_S10e02938g	weakly similar to uniprot|Q06160 Saccharomyces cerevisiae YLR313C (ohnolog of YLL021W) SPH1 Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
LALA0_S10e02960g	similar to uniprot|P36523 Saccharomyces cerevisiae YLR312W-A MRPL15 Mitochondrial ribosomal protein of the large subunit
LALA0_S10e02982g	highly similar to uniprot|P45818 Saccharomyces cerevisiae YGL171W ROK1 ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis
LALA0_S10e03004g	highly similar to uniprot|Q12233 Saccharomyces cerevisiae YPR020W ATP20 Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
LALA0_S10e03026g	highly similar to uniprot|P30665 Saccharomyces cerevisiae YPR019W MCM4 Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
LALA0_S10e03048g	similar to uniprot|Q12495 Saccharomyces cerevisiae YPR018W RLF2 Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin
LALA0_S10e03070g	weakly similar to uniprot|P45819 Saccharomyces cerevisiae YGL170C SPO74 Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
LALA0_S10e03092g	similar to uniprot|P32601 Saccharomyces cerevisiae YPR017C DSS4 Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
LALA0_S10e03114g	highly similar to uniprot|Q12522 Saccharomyces cerevisiae YPR016C TIF6 Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
LALA0_S10e03136g	weakly similar to uniprot|Q6Q5F4 Saccharomyces cerevisiae YPR015C Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
LALA0_S10e03180g	similar to uniprot|Q12251 Saccharomyces cerevisiae YPR011C Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S10e03202g	similar to uniprot|A5Z2X5 Saccharomyces cerevisiae YPR010C-A Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
LALA0_S10e03224g	highly similar to Lachancea thermotolerans KLTH0H09020g hypothetical protein
LALA0_S10e03246g	similar to uniprot|P53212 Saccharomyces cerevisiae YGR021W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S10e03268g	highly similar to uniprot|P39111 Saccharomyces cerevisiae YGR020C VMA7 Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
LALA0_S10e03290g	similar to uniprot|Q12114 Saccharomyces cerevisiae YLR330W CHS5 Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
LALA0_S10e03312g	highly similar to uniprot|P17649 Saccharomyces cerevisiae YGR019W UGA1 Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization
LALA0_S10e03334g	similar to uniprot|P53210 Saccharomyces cerevisiae YGR017W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
LALA0_S10e03356g	similar to uniprot|C5E300 Lachancea thermotolerans KLTH0H09174g hypothetical protein
LALA0_S10e03378g	similar to uniprot|P13856 Saccharomyces cerevisiae YGR152C RSR1 GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
LALA0_S10e03400g	similar to uniprot|P31755 Saccharomyces cerevisiae YGL038C OCH1 Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
LALA0_S10e03422g	similar to uniprot|P53184 Saccharomyces cerevisiae YGL037C PNC1 Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span
LALA0_S10e03444g	weakly similar to uniprot|P53185 Saccharomyces cerevisiae YGL036W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene
LALA0_S10e03466g	highly similar to uniprot|P48234 Saccharomyces cerevisiae YGR145W ENP2 Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
LALA0_S10e03488g	similar to uniprot|P40357 Saccharomyces cerevisiae YGR009C SEC9 t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog
LALA0_S10e03510g	similar to uniprot|C5E302 Lachancea thermotolerans KLTH0H09218g hypothetical protein
LALA0_S10e03532g	weakly similar to uniprot|P27705 Saccharomyces cerevisiae YGL035C MIG1 Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
LALA0_S10e03554g	similar to uniprot|C5E304 Lachancea thermotolerans KLTH0H09262g hypothetical protein
LALA0_S10e03576g	similar to uniprot|P53187 Saccharomyces cerevisiae YGL033W HOP2 Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
LALA0_S10e03598g	highly similar to uniprot|C5E304 Lachancea thermotolerans KLTH0H09262g hypothetical protein
LALA0_S10e03620g	similar to uniprot|P37293 Saccharomyces cerevisiae YGR147C NAT2 Protein with an apparent role in acetylation of N-terminal methionine residues
LALA0_S10e03642g	similar to uniprot|P32781 Saccharomyces cerevisiae YGL032C AGA2 Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
LALA0_S10e03664g	highly similar to uniprot|P24000 Saccharomyces cerevisiae YGR148C (ohnolog of YGL031C) RPL24B Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
LALA0_S10e03686g	some similarities with uniprot|P14120 Saccharomyces cerevisiae YGL030W RPL30 Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
LALA0_S10e03708g	similar to uniprot|Q3E731 Saccharomyces cerevisiae YLL018C-A COX19 Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
LALA0_S10e03730g	highly similar to uniprot|P04802 Saccharomyces cerevisiae YLL018C DPS1 Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
LALA0_S10e03752g	some similarities with uniprot|P04821 Saccharomyces cerevisiae YLR310C (ohnolog of YLL016W) CDC25 Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1
LALA0_S10e03774g	similar to uniprot|Q06704 Saccharomyces cerevisiae YLR309C IMH1 Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
LALA0_S10e03796g	similar to uniprot|Q06703 Saccharomyces cerevisiae YLR308W CDA2 Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
LALA0_S10e03818g	similar to uniprot|P52491 Saccharomyces cerevisiae YLR306W UBC12 Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes
LALA0_S10e03840g	highly similar to uniprot|P05150 Saccharomyces cerevisiae YJL088W ARG3 Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
LALA0_S10e03862g	similar to uniprot|P09880 Saccharomyces cerevisiae YJL087C TRL1 tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes
LALA0_S10e03884g	similar to uniprot|P19658 Saccharomyces cerevisiae YJL085W EXO70 Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding
LALA0_S10e03906g	similar to uniprot|P47029 Saccharomyces cerevisiae YJL084C (ohnolog of YKR021W) ALY2 Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins
LALA0_S10e03928g	similar to uniprot|P36116 Saccharomyces cerevisiae YKR020W VPS51 Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
LALA0_S10e03950g	weakly similar to uniprot|P47030 Saccharomyces cerevisiae YJL083W (ohnolog of YKR019C) TAX4 EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS
LALA0_S10e03972g	similar to uniprot|P47031 Saccharomyces cerevisiae YJL082W (ohnolog of YKR018C) IML2 Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S10e03994g	similar to uniprot|P36113 Saccharomyces cerevisiae YKR017C Putative protein of unknown function; contains a RING finger motif
LALA0_S10e04016g	similar to uniprot|P80428 Saccharomyces cerevisiae YJL081C ARP4 Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
LALA0_S10e04038g	similar to uniprot|P36112 Saccharomyces cerevisiae YKR016W FCJ1 Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions; impairs oligomerization of F1F0-ATP synthase; null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance
LALA0_S10e04060g	hypothetical protein
LALA0_S10e04082g	similar to uniprot|C5E339 Lachancea thermotolerans KLTH0H10142g hypothetical protein
LALA0_S10e04104g	similar to uniprot|P36018 Saccharomyces cerevisiae YKR014C YPT52 Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
LALA0_S10e04126g	similar to uniprot|P06105 Saccharomyces cerevisiae YJL080C SCP160 Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
LALA0_S10e04148g	some similarities with uniprot|P47033 Saccharomyces cerevisiae YJL078C PRY3 Cell wall protein with a role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
LALA0_S10e04170g	similar to uniprot|P47032 Saccharomyces cerevisiae YJL079C (ohnolog of YKR013W) PRY1 Protein of unknown function
LALA0_S10e04192g	weakly similar to uniprot|Q07824 Saccharomyces cerevisiae YLL028W TPO1 Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
LALA0_S10e04214g	weakly similar to uniprot|Q96VH4 Saccharomyces cerevisiae YCL026C-B HBN1 Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion
LALA0_S10e04236g	weakly similar to uniprot|P39529 Saccharomyces cerevisiae YJL206C Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment
LALA0_S10e04280g	weakly similar to uniprot|Q02209 Saccharomyces cerevisiae YKR011C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
LALA0_S10e04302g	similar to uniprot|P05066 Saccharomyces cerevisiae YOR386W PHR1 DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
LALA0_S10e04324g	similar to uniprot|P38765 Saccharomyces cerevisiae YHR029C YHI9 Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
LALA0_S10e04346g	weakly similar to uniprot|P47035 Saccharomyces cerevisiae YJL076W (ohnolog of YKR010C) NET1 Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure
LALA0_S10e04368g	similar to uniprot|P47037 Saccharomyces cerevisiae YJL074C SMC3 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
LALA0_S10e04412g	similar to uniprot|P38355 Saccharomyces cerevisiae YBR287W Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene
LALA0_S10e04434g	similar to uniprot|P40358 Saccharomyces cerevisiae YJL073W JEM1 DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
LALA0_S10e04456g	similar to uniprot|P37302 Saccharomyces cerevisiae YBR286W APE3 Vacuolar aminopeptidase Y, processed to mature form by Prb1p
LALA0_S10e04500g	similar to uniprot|C5DNA2 Lachancea thermotolerans KLTH0G15334g hypothetical protein
LALA0_S10e04522g	similar to uniprot|P40359 Saccharomyces cerevisiae YJL072C PSF2 Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
LALA0_S10e04544g	similar to uniprot|P40360 Saccharomyces cerevisiae YJL071W ARG2 Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p
LALA0_S10e04566g	similar to uniprot|P40361 Saccharomyces cerevisiae YJL070C (ohnolog of YBR284W) Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene
LALA0_S10e04610g	highly similar to uniprot|P37292 Saccharomyces cerevisiae YBR263W SHM1 Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
LALA0_S10e04632g	similar to uniprot|P36017 Saccharomyces cerevisiae YOR089C (ohnolog of YNL093W) VPS21 Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog
LALA0_S10e04654g	weakly similar to uniprot|P29539 Saccharomyces cerevisiae YBR275C RIF1 Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
LALA0_S10e04676g	similar to uniprot|P38147 Saccharomyces cerevisiae YBR274W CHK1 Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
LALA0_S10e04698g	similar to uniprot|P47049 Saccharomyces cerevisiae YJL048C (ohnolog of YBR273C) UBX6 UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
LALA0_S10e04720g	weakly similar to uniprot|P47048 Saccharomyces cerevisiae YJL049W Putative protein of unknown function; YJL049W is a non-essential gene
LALA0_S10e04742g	similar to uniprot|P38348 Saccharomyces cerevisiae YBR272C HSM3 Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b
LALA0_S10e04764g	highly similar to uniprot|P47047 Saccharomyces cerevisiae YJL050W MTR4 ATP-dependent 3'-5' RNA helicase of the Dead-box family, involved in nuclear RNA processing and degradation both as a component of the TRAMP complex and in TRAMP independent processes; has a KOW domain that shows RNA binding activity
LALA0_S10e04786g	similar to uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
LALA0_S10e04808g	similar to uniprot|Q05874 Saccharomyces cerevisiae YLR285W NNT1 Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
LALA0_S10e04830g	similar to uniprot|Q05871 Saccharomyces cerevisiae YLR284C Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced
LALA0_S10e04852g	similar to uniprot|Q05867 Saccharomyces cerevisiae YLR283W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
LALA0_S10e04874g	similar to uniprot|P53275 Saccharomyces cerevisiae YGR127W Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
LALA0_S10e04896g	similar to uniprot|Q05863 Saccharomyces cerevisiae YLR281C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
LALA0_S10e04918g	similar to uniprot|Q05854 Saccharomyces cerevisiae YLR278C Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
LALA0_S10e04940g	highly similar to uniprot|Q08553 Saccharomyces cerevisiae YOR179C (ohnolog of YLR277C) SYC1 Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs
LALA0_S10e04962g	highly similar to uniprot|Q06218 Saccharomyces cerevisiae YLR276C DBP9 ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit
LALA0_S10e04984g	highly similar to uniprot|Q06217 Saccharomyces cerevisiae YLR275W SMD2 Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
LALA0_S10e05006g	highly similar to uniprot|P29496 Saccharomyces cerevisiae YLR274W MCM5 Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
LALA0_S10e05050g	weakly similar to uniprot|P28006 Saccharomyces cerevisiae YOR178C (ohnolog of YLR273C) GAC1 Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
LALA0_S10e05072g	similar to uniprot|C5DNB0 Lachancea thermotolerans KLTH0G15532g hypothetical protein
LALA0_S10e05116g	similar to uniprot|Q06156 Saccharomyces cerevisiae YLR272C YCS4 Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus
LALA0_S10e05138g	highly similar to uniprot|P16622 Saccharomyces cerevisiae YOR176W HEM15 Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
LALA0_S10e05160g	similar to uniprot|Q03130 Saccharomyces cerevisiae YOR175C ALE1 Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
LALA0_S10e05182g	similar to uniprot|Q12343 Saccharomyces cerevisiae YOR174W MED4 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
LALA0_S10e05204g	weakly similar to uniprot|Q06152 Saccharomyces cerevisiae YLR271W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
LALA0_S10e05226g	highly similar to uniprot|Q12123 Saccharomyces cerevisiae YOR173W (ohnolog of YLR270W) DCS2 Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance
LALA0_S10e05248g	highly similar to uniprot|P22214 Saccharomyces cerevisiae YLR268W SEC22 R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
LALA0_S10e05270g	weakly similar to Lachancea thermotolerans KLTH0F00264g hypothetical protein
LALA0_S10e05292g	weakly similar to uniprot|P38282 Saccharomyces cerevisiae YBR152W SPP381 mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
LALA0_S10e05314g	similar to uniprot|P33312 Saccharomyces cerevisiae YBR153W RIB7 Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
LALA0_S10e05336g	highly similar to uniprot|P20434 Saccharomyces cerevisiae YBR154C RPB5 RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
LALA0_S10e05358g	similar to uniprot|Q99247 Saccharomyces cerevisiae YOL087C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
LALA0_S10e05380g	similar to uniprot|Q3E835 Saccharomyces cerevisiae YOL086W-A Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF1, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability
LALA0_S10e05402g	highly similar to uniprot|P38120 Saccharomyces cerevisiae YBR146W MRPS9 Mitochondrial ribosomal protein of the small subunit
LALA0_S10e05424g	highly similar to uniprot|P38113 Saccharomyces cerevisiae YBR145W (ohnolog of YOL086C) ADH5 Alcohol dehydrogenase isoenzyme V; involved in ethanol production
LALA0_S10e05446g	highly similar to uniprot|P00359 Saccharomyces cerevisiae YGR192C (ohnolog of YJR009C) TDH3 Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall
LALA0_S10e05468g	similar to uniprot|Q12252 Saccharomyces cerevisiae YOL084W PHM7 Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
LALA0_S10e05490g	similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny
LALA0_S10e05512g	weakly similar to uniprot|Q12292 Saccharomyces cerevisiae YOL083W ATG34 Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog
LALA0_S10e05534g	highly similar to uniprot|P12385 Saccharomyces cerevisiae YBR143C SUP45 Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin
LALA0_S10e05556g	similar to uniprot|P38112 Saccharomyces cerevisiae YBR142W MAK5 Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
LALA0_S10e05578g	similar to uniprot|P38278 Saccharomyces cerevisiae YBR141C Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene
LALA0_S10e05600g	similar to uniprot|P18963 Saccharomyces cerevisiae YBR140C (ohnolog of YOL081W) IRA1 GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase
LALA0_S10e05622g	similar to uniprot|Q08237 Saccharomyces cerevisiae YOL080C REX4 Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
LALA0_S10e05644g	similar to uniprot|Q08236 Saccharomyces cerevisiae YOL078W AVO1 Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
LALA0_S10e05666g	similar to uniprot|P38109 Saccharomyces cerevisiae YBR139W Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
LALA0_S10e05688g	similar to uniprot|P81451 Saccharomyces cerevisiae YOL077W-A ATP19 Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
LALA0_S10e05710g	highly similar to uniprot|Q08235 Saccharomyces cerevisiae YOL077C BRX1 Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
LALA0_S10e05732g	similar to uniprot|Q12387 Saccharomyces cerevisiae YOL076W MDM20 Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly
LALA0_S10e05754g	similar to uniprot|P38069 Saccharomyces cerevisiae YBR015C MNN2 Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
LALA0_S10e05776g	similar to uniprot|Q12438 Saccharomyces cerevisiae YDL010W (ohnolog of YBR014C) GRX6 Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7
LALA0_S10e05798g	similar to uniprot|Q12157 Saccharomyces cerevisiae YDL008W APC11 Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
LALA0_S10e05820g	weakly similar to uniprot|Q03446 Saccharomyces cerevisiae YDR003W (ohnolog of YBR005W) RCR2 Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p
LALA0_S10e05842g	highly similar to uniprot|P38067 Saccharomyces cerevisiae YBR006W UGA2 Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm
LALA0_S10e05864g	similar to uniprot|P25301 Saccharomyces cerevisiae YDR004W RAD57 Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
LALA0_S10e05886g	similar to uniprot|P41910 Saccharomyces cerevisiae YDR005C MAF1 Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB
LALA0_S10e05908g	weakly similar to uniprot|P38213 Saccharomyces cerevisiae YBR007C DSF2 Deletion suppressor of mpt5 mutation
LALA0_S10e05930g	similar to uniprot|P40317 Saccharomyces cerevisiae YDR006C SOK1 Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
LALA0_S10e05952g	similar to uniprot|P33329 Saccharomyces cerevisiae YDR436W (ohnolog of YML016C) PPZ2 Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
LALA0_S10e05974g	similar to uniprot|Q04082 Saccharomyces cerevisiae YDR437W GPI19 Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P
LALA0_S10e05996g	weakly similar to uniprot|P50109 Saccharomyces cerevisiae YML017W PSP2 Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing
LALA0_S10e06018g	similar to uniprot|Q04083 Saccharomyces cerevisiae YDR438W (ohnolog of YML018C) THI74 Mitochondrial transporter repressible by thiamine
LALA0_S10e06040g	similar to uniprot|Q03723 Saccharomyces cerevisiae YML019W OST6 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
LALA0_S10e06062g	weakly similar to uniprot|Q04087 Saccharomyces cerevisiae YDR439W LRS4 Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
LALA0_S10e06084g	similar to uniprot|Q03722 Saccharomyces cerevisiae YML020W Putative protein of unknown function
LALA0_S10e06106g	similar to uniprot|P12887 Saccharomyces cerevisiae YML021C UNG1 Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
LALA0_S11e00100g	hypothetical protein
LALA0_S11e00122g	weakly similar to uniprot|P25591 Saccharomyces cerevisiae YCL063W VAC17 Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p
LALA0_S11e00144g	weakly similar to uniprot|P25588 Saccharomyces cerevisiae YCL061C MRC1 S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres
LALA0_S11e00166g	highly similar to uniprot|P25586 Saccharomyces cerevisiae YCL059C KRR1 Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
LALA0_S11e00188g	similar to uniprot|Q2V2Q1 Saccharomyces cerevisiae YCL058W-A ADF1 Transcriptional repressor encoded by the antisense strand of the FYV5 gene; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand
LALA0_S11e00210g	similar to uniprot|Q96VH5 Saccharomyces cerevisiae YCL057C-A Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S11e00232g	similar to uniprot|C5DJZ6 Lachancea thermotolerans KLTH0F00594g hypothetical protein
LALA0_S11e00254g	similar to uniprot|C5DJZ7 Lachancea thermotolerans KLTH0F00616g hypothetical protein
LALA0_S11e00276g	similar to Lachancea thermotolerans KLTH0F00682g hypothetical protein
LALA0_S11e00298g	similar to uniprot|P25583 Saccharomyces cerevisiae YCL055W KAR4 Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
LALA0_S11e00320g	highly similar to Lachancea thermotolerans KLTH0F00748g hypothetical protein
LALA0_S11e00342g	highly similar to uniprot|P25582 Saccharomyces cerevisiae YCL054W SPB1 AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
LALA0_S11e00364g	similar to uniprot|P25580 Saccharomyces cerevisiae YCL052C PBN1 Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
LALA0_S11e00386g	similar to Lachancea thermotolerans KLTH0F00748g hypothetical protein
LALA0_S11e00408g	highly similar to uniprot|P00128 Saccharomyces cerevisiae YDR529C QCR7 Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly
LALA0_S11e00430g	similar to uniprot|P22108 Saccharomyces cerevisiae YDR530C (ohnolog of YCL050C) APA2 Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
LALA0_S11e00452g	similar to uniprot|Q04430 Saccharomyces cerevisiae YDR531W CAB1 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
LALA0_S11e00474g	weakly similar to uniprot|Q6Q537 Saccharomyces cerevisiae YDR532C KRE28 Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components
LALA0_S11e00496g	similar to uniprot|Q04418 Saccharomyces cerevisiae YDR527W RBA50 Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
LALA0_S11e00518g	similar to uniprot|P56508 Saccharomyces cerevisiae YDR525W-A SNA2 Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
LALA0_S11e00540g	similar to uniprot|P32460 Saccharomyces cerevisiae YIR030C DCG1 Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain
LALA0_S11e00584g	highly similar to uniprot|Q3E6R4 Saccharomyces cerevisiae YDR524C-B (ohnolog of YCL048W-A) Putative protein of unknown function
LALA0_S11e00606g	some similarities with uniprot|Q04412 Saccharomyces cerevisiae YDR524C AGE1 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif
LALA0_S11e00628g	similar to uniprot|P08458 Saccharomyces cerevisiae YDR523C SPS1 Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
LALA0_S11e00650g	similar to uniprot|P08459 Saccharomyces cerevisiae YDR522C (ohnolog of YCL048W) SPS2 Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component
LALA0_S11e00672g	similar to uniprot|Q04411 Saccharomyces cerevisiae YDR520C URC2 Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
LALA0_S11e00694g	similar to uniprot|P25576 Saccharomyces cerevisiae YCL047C POF1 Protein involved in the filamentation pathway; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion
LALA0_S11e00716g	similar to uniprot|P32472 Saccharomyces cerevisiae YDR519W FPR2 Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking
LALA0_S11e00738g	similar to uniprot|P25574 Saccharomyces cerevisiae YCL045C EMC1 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p
LALA0_S11e00760g	similar to uniprot|P25573 Saccharomyces cerevisiae YCL044C MGR1 Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
LALA0_S11e00782g	similar to uniprot|P32474 Saccharomyces cerevisiae YDR518W (ohnolog of YCL043C) EUG1 Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
LALA0_S11e00804g	similar to uniprot|Q04410 Saccharomyces cerevisiae YDR517W GRH1 Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
LALA0_S11e00826g	highly similar to uniprot|Q04409 Saccharomyces cerevisiae YDR516C (ohnolog of YCL040W) EMI2 Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
LALA0_S11e00848g	similar to uniprot|P25569 Saccharomyces cerevisiae YCL039W GID7 Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions
LALA0_S11e00870g	similar to uniprot|P25568 Saccharomyces cerevisiae YCL038C ATG22 Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
LALA0_S11e00892g	weakly similar to uniprot|Q12034 Saccharomyces cerevisiae YDR515W (ohnolog of YCL037C) SLF1 RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts
LALA0_S11e00914g	similar to uniprot|P25370 Saccharomyces cerevisiae YDR514C (ohnolog of YCL036W) Protein of unknown function that localizes to mitochondria; overexpression of YDR514C affects endocytic protein trafficking
LALA0_S11e00936g	hypothetical protein
LALA0_S11e00958g	weakly similar to uniprot|G8ZQQ7 Torulaspora delbrueckii TDEL0C06550 hypothetical protein
LALA0_S11e00980g	similar to uniprot|P17695 Saccharomyces cerevisiae YDR513W (ohnolog of YCL035C) GRX2 Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress
LALA0_S11e01002g	similar to uniprot|P25369 Saccharomyces cerevisiae YCL034W LSB5 Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
LALA0_S11e01024g	similar to uniprot|P25566 Saccharomyces cerevisiae YCL033C MXR2 Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
LALA0_S11e01046g	some similarities with uniprot|Q04406 Saccharomyces cerevisiae YDR512C EMI1 Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs
LALA0_S11e01068g	similar to uniprot|P25344 Saccharomyces cerevisiae YCL032W STE50 Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
LALA0_S11e01090g	similar to uniprot|P25368 Saccharomyces cerevisiae YCL031C RRP7 Essential protein involved in rRNA processing and ribosome biogenesis
LALA0_S11e01112g	similar to uniprot|Q02562 Saccharomyces cerevisiae YDR511W ACN9 Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
LALA0_S11e01134g	weakly similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein
LALA0_S11e01156g	similar to uniprot|P11709 Saccharomyces cerevisiae YCL029C BIK1 Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170
LALA0_S11e01178g	highly similar to uniprot|P00815 Saccharomyces cerevisiae YCL030C HIS4 Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
LALA0_S11e01200g	weakly similar to uniprot|P47032 Saccharomyces cerevisiae YJL079C (ohnolog of YKR013W) PRY1 Protein of unknown function
LALA0_S11e01222g	weakly similar to uniprot|P11710 Saccharomyces cerevisiae YCL027W FUS1 Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate
LALA0_S11e01244g	similar to uniprot|P37261 Saccharomyces cerevisiae YCL026C-A FRM2 Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; expression induced in cells treated with the mycotoxin patulin; has similarity to bacterial nitroreductases
LALA0_S11e01266g	similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C (ohnolog of YCL025C) GNP1 High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
LALA0_S11e01288g	similar to uniprot|P48813 Saccharomyces cerevisiae YDR508C (ohnolog of YCL025C) GNP1 High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
LALA0_S11e01310g	highly similar to uniprot|Q12306 Saccharomyces cerevisiae YDR510W SMT3 Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
LALA0_S11e01354g	similar to uniprot|Q12263 Saccharomyces cerevisiae YDR507C (ohnolog of YCL024W) GIN4 Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p
LALA0_S11e01376g	similar to uniprot|Q04399 Saccharomyces cerevisiae YDR506C Possible membrane-localized protein
LALA0_S11e01398g	similar to uniprot|P50896 Saccharomyces cerevisiae YDR505C (ohnolog of YLR177W) PSP1 Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
LALA0_S11e01420g	similar to uniprot|P14306 Saccharomyces cerevisiae YLR178C TFS1 Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase
LALA0_S11e01442g	similar to uniprot|Q04396 Saccharomyces cerevisiae YDR503C LPP1 Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
LALA0_S11e01464g	highly similar to uniprot|P19358 Saccharomyces cerevisiae YDR502C (ohnolog of YLR180W) SAM2 S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
LALA0_S11e01486g	weakly similar to uniprot|Q07057 Saccharomyces cerevisiae YLR181C VTA1 Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain
LALA0_S11e01508g	similar to uniprot|P28625 Saccharomyces cerevisiae YMR152W YIM1 Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S11e01530g	similar to uniprot|P09959 Saccharomyces cerevisiae YLR182W SWI6 Transcription cofactor, forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization
LALA0_S11e01552g	weakly similar to uniprot|Q04383 Saccharomyces cerevisiae YDR501W (ohnolog of YLR183C) PLM2 Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; similar to TOS4
LALA0_S11e01574g	similar to uniprot|P40445 Saccharomyces cerevisiae YIL166C Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
LALA0_S11e01596g	similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation
LALA0_S11e01618g	similar to uniprot|P47137 Saccharomyces cerevisiae YJR096W Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
LALA0_S11e01640g	highly similar to uniprot|P51402 Saccharomyces cerevisiae YDR500C (ohnolog of YLR185W) RPL37B Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
LALA0_S11e01662g	similar to uniprot|Q04377 Saccharomyces cerevisiae YDR499W LCD1 Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP
LALA0_S11e01684g	highly similar to uniprot|Q06287 Saccharomyces cerevisiae YLR186W EMG1 Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers
LALA0_S11e01706g	similar to uniprot|P53835 Saccharomyces cerevisiae YNL279W PRM1 Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
LALA0_S11e01728g	similar to uniprot|P53836 Saccharomyces cerevisiae YNL278W (ohnolog of YLR187W) CAF120 Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
LALA0_S11e01750g	similar to uniprot|P33310 Saccharomyces cerevisiae YLR188W MDL1 Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
LALA0_S11e01772g	highly similar to uniprot|P08465 Saccharomyces cerevisiae YNL277W MET2 L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
LALA0_S11e01794g	similar to uniprot|Q06321 Saccharomyces cerevisiae YLR189C ATG26 UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
LALA0_S11e01816g	similar to uniprot|P40015 Saccharomyces cerevisiae YER019W ISC1 Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance
LALA0_S11e01838g	weakly similar to uniprot|P40014 Saccharomyces cerevisiae YER018C SPC25 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
LALA0_S11e01860g	similar to uniprot|P25625 Saccharomyces cerevisiae YCR044C PER1 Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
LALA0_S11e01882g	similar to uniprot|P53838 Saccharomyces cerevisiae YNL275W BOR1 Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1
LALA0_S11e01904g	similar to uniprot|P53839 Saccharomyces cerevisiae YNL274C GOR1 Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S11e01926g	similar to uniprot|P25361 Saccharomyces cerevisiae YCR043C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
LALA0_S11e01948g	similar to uniprot|P23255 Saccharomyces cerevisiae YCR042C TAF2 TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation
LALA0_S11e01970g	weakly similar to uniprot|Q12232 Saccharomyces cerevisiae YOR154W SLP1 Integral membrane protein of unknown function; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins
LALA0_S11e01992g	some similarities with uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
LALA0_S11e02014g	weakly similar to uniprot|P25381 Saccharomyces cerevisiae YCR045C RRT12 Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores
LALA0_S11e02036g	similar to uniprot|P53840 Saccharomyces cerevisiae YNL273W TOF1 Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
LALA0_S11e02058g	similar to uniprot|P39981 Saccharomyces cerevisiae YEL064C AVT2 Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
LALA0_S11e02080g	similar to uniprot|P17065 Saccharomyces cerevisiae YNL272C SEC2 Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles
LALA0_S11e02102g	similar to uniprot|P41832 Saccharomyces cerevisiae YNL271C BNI1 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
LALA0_S11e02124g	similar to uniprot|P32487 Saccharomyces cerevisiae YNL268W LYP1 Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
LALA0_S11e02146g	similar to uniprot|P39104 Saccharomyces cerevisiae YNL267W PIK1 Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
LALA0_S11e02168g	similar to uniprot|P53230 Saccharomyces cerevisiae YGR046W TAM41 Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud
LALA0_S11e02190g	similar to uniprot|P53843 Saccharomyces cerevisiae YNL265C IST1 Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p
LALA0_S11e02212g	similar to uniprot|P33339 Saccharomyces cerevisiae YGR047C TFC4 One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
LALA0_S11e02234g	similar to uniprot|P53044 Saccharomyces cerevisiae YGR048W UFD1 Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol
LALA0_S11e02256g	similar to uniprot|P53120 Saccharomyces cerevisiae YGL140C Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
LALA0_S11e02278g	similar to uniprot|P53844 Saccharomyces cerevisiae YNL264C PDR17 Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
LALA0_S11e02300g	similar to uniprot|P52868 Saccharomyces cerevisiae YGL128C CWC23 Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p
LALA0_S11e02322g	similar to uniprot|P53845 Saccharomyces cerevisiae YNL263C YIF1 Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3
LALA0_S11e02344g	similar to uniprot|P21951 Saccharomyces cerevisiae YNL262W POL2 Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
LALA0_S11e02366g	similar to uniprot|P50874 Saccharomyces cerevisiae YNL261W ORC5 Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
LALA0_S11e02388g	weakly similar to uniprot|P38852 Saccharomyces cerevisiae YHR156C LIN1 Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
LALA0_S11e02410g	similar to uniprot|P53846 Saccharomyces cerevisiae YNL260C Putative protein of unknown function with similarity to a human protein overexpressed in oral cancers; essential gene with defects in anaerobic and filamentous growth; localizes to the nucleus and cytoplasm
LALA0_S11e02432g	highly similar to uniprot|P38636 Saccharomyces cerevisiae YNL259C ATX1 Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
LALA0_S11e02454g	similar to uniprot|P53847 Saccharomyces cerevisiae YNL258C DSL1 Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p
LALA0_S11e02476g	similar to uniprot|P38851 Saccharomyces cerevisiae YHR155W (ohnolog of YNL257C) YSP1 Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone
LALA0_S11e02498g	similar to uniprot|P54857 Saccharomyces cerevisiae YDR058C TGL2 Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli
LALA0_S11e02520g	some similarities with uniprot|Q00539 Saccharomyces cerevisiae YHR086W NAM8 RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
LALA0_S11e02542g	similar to uniprot|P53318 Saccharomyces cerevisiae YGR255C COQ6 Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
LALA0_S11e02564g	similar to uniprot|P53848 Saccharomyces cerevisiae YNL256W FOL1 Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
LALA0_S11e02586g	similar to uniprot|P53849 Saccharomyces cerevisiae YNL255C GIS2 Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
LALA0_S11e02608g	weakly similar to uniprot|P53850 Saccharomyces cerevisiae YNL254C RTC4 Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
LALA0_S11e02630g	weakly similar to uniprot|P53851 Saccharomyces cerevisiae YNL253W TEX1 Protein involved in mRNA export, component of the transcription export (TREX) complex
LALA0_S11e02652g	similar to uniprot|P36528 Saccharomyces cerevisiae YNL252C MRPL17 Mitochondrial ribosomal protein of the large subunit
LALA0_S11e02674g	similar to uniprot|P53617 Saccharomyces cerevisiae YNL251C NRD1 RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex mediates termination of snoRNAs and cryptic unstable transcripts (CUTs); interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; required for 3' end maturation of nonpolyadenylated RNAs
LALA0_S11e02696g	similar to uniprot|P12753 Saccharomyces cerevisiae YNL250W RAD50 Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining
LALA0_S11e02718g	similar to uniprot|P53583 Saccharomyces cerevisiae YNL249C MPA43 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S11e02740g	highly similar to uniprot|Q01080 Saccharomyces cerevisiae YNL248C RPA49 RNA polymerase I subunit A49
LALA0_S11e02762g	similar to uniprot|P47138 Saccharomyces cerevisiae YJR097W JJJ3 Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
LALA0_S11e02784g	similar to uniprot|P47139 Saccharomyces cerevisiae YJR098C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S11e02806g	similar to uniprot|P53852 Saccharomyces cerevisiae YNL247W Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments
LALA0_S11e02828g	similar to uniprot|P53853 Saccharomyces cerevisiae YNL246W VPS75 NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair
LALA0_S11e02850g	similar to uniprot|P53854 Saccharomyces cerevisiae YNL245C CWC25 Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p
LALA0_S11e02872g	highly similar to uniprot|P32911 Saccharomyces cerevisiae YNL244C SUI1 Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
LALA0_S11e02894g	some similarities with uniprot|P33338 Saccharomyces cerevisiae YNL243W SLA2 Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo
LALA0_S11e02938g	similar to uniprot|C5DKC3 Lachancea thermotolerans KLTH0F03454g hypothetical protein
LALA0_S11e02960g	weakly similar to uniprot|P32800 Saccharomyces cerevisiae YJL210W PEX2 RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
LALA0_S11e02982g	weakly similar to uniprot|P07252 Saccharomyces cerevisiae YJL209W CBP1 Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p
LALA0_S11e03004g	similar to uniprot|P08466 Saccharomyces cerevisiae YJL208C NUC1 Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
LALA0_S11e03026g	similar to uniprot|P39526 Saccharomyces cerevisiae YJL207C LAA1 AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
LALA0_S11e03048g	weakly similar to uniprot|P40467 Saccharomyces cerevisiae YIL130W ASG1 Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
LALA0_S11e03070g	similar to uniprot|Q02820 Saccharomyces cerevisiae YJL205C NCE101 Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences
LALA0_S11e03092g	weakly similar to uniprot|Q12338 Saccharomyces cerevisiae YLR154C RNH203 Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
LALA0_S11e03114g	similar to Lachancea thermotolerans KLTH0F03498g hypothetical protein
LALA0_S11e03136g	similar to uniprot|P39531 Saccharomyces cerevisiae YJL204C RCY1 F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
LALA0_S11e03158g	similar to uniprot|C5DKH7 Lachancea thermotolerans KLTH0F04752g hypothetical protein
LALA0_S11e03202g	similar to uniprot|P32525 Saccharomyces cerevisiae YJL201W ECM25 Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
LALA0_S11e03224g	some similarities with uniprot|P25300 Saccharomyces cerevisiae YCR038C BUD5 GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types
LALA0_S11e03246g	highly similar to uniprot|P39533 Saccharomyces cerevisiae YJL200C ACO2 Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
LALA0_S11e03290g	similar to uniprot|P25360 Saccharomyces cerevisiae YCR037C (ohnolog of YJL198W) PHO87 Low-affinity inorganicphosphate (Pi) transporter, involved in activation of PHOpathway; expression is independent of Pi concentration andPho4p activity; contains 12 membrane-spanning segments
LALA0_S11e03312g	similar to uniprot|P39538 Saccharomyces cerevisiae YJL197W UBP12 Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins
LALA0_S11e03334g	similar to uniprot|P25332 Saccharomyces cerevisiae YCR036W RBK1 Putative ribokinase
LALA0_S11e03356g	similar to uniprot|P25359 Saccharomyces cerevisiae YCR035C RRP43 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8)
LALA0_S11e03378g	highly similar to uniprot|P25358 Saccharomyces cerevisiae YCR034W (ohnolog of YJL196C) FEN1 Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
LALA0_S11e03400g	weakly similar to uniprot|P25357 Saccharomyces cerevisiae YCR033W SNT1 Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
LALA0_S11e03422g	similar to uniprot|P09119 Saccharomyces cerevisiae YJL194W CDC6 Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p
LALA0_S11e03444g	similar to uniprot|P25356 Saccharomyces cerevisiae YCR032W BPH1 PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
LALA0_S11e03466g	similar to uniprot|P39543 Saccharomyces cerevisiae YJL192C SOP4 ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER
LALA0_S11e03488g	highly similar to uniprot|P06367 Saccharomyces cerevisiae YCR031C (ohnolog of YJL191W) RPS14A Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
LALA0_S11e03510g	highly similar to uniprot|P0C0W1 Saccharomyces cerevisiae YJL190C RPS22A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
LALA0_S11e03532g	highly similar to uniprot|P04650 Saccharomyces cerevisiae YJL189W RPL39 Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1
LALA0_S11e03554g	similar to uniprot|P32944 Saccharomyces cerevisiae YJL187C SWE1 Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
LALA0_S11e03576g	similar to uniprot|P46982 Saccharomyces cerevisiae YJL186W MNN5 Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
LALA0_S11e03598g	similar to uniprot|P25623 Saccharomyces cerevisiae YCR030C SYP1 Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
LALA0_S11e03620g	weakly similar to uniprot|P46983 Saccharomyces cerevisiae YJL185C Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene
LALA0_S11e03642g	similar to uniprot|P32445 Saccharomyces cerevisiae YCR028C-A RIM1 Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication
LALA0_S11e03664g	similar to uniprot|P46984 Saccharomyces cerevisiae YJL184W GON7 Component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; implicated in osmotic stress response
LALA0_S11e03686g	similar to uniprot|P25621 Saccharomyces cerevisiae YCR028C FEN2 Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph
LALA0_S11e03708g	similar to uniprot|P46985 Saccharomyces cerevisiae YJL183W MNN11 Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
LALA0_S11e03730g	weakly similar to uniprot|P47101 Saccharomyces cerevisiae YJR030C (ohnolog of YJL181W) Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; YJR030C is a non-essential gene
LALA0_S11e03752g	similar to uniprot|P22135 Saccharomyces cerevisiae YJL180C ATP12 Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
LALA0_S11e03774g	similar to uniprot|P46988 Saccharomyces cerevisiae YJL179W PFD1 Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha-and gamma-tubulin
LALA0_S11e03796g	similar to uniprot|P46989 Saccharomyces cerevisiae YJL178C ATG27 Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site
LALA0_S11e03818g	highly similar to uniprot|P05740 Saccharomyces cerevisiae YKL180W (ohnolog of YJL177W) RPL17A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
LALA0_S11e03840g	similar to uniprot|P34237 Saccharomyces cerevisiae YKL179C COY1 Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
LALA0_S11e03862g	similar to uniprot|P32591 Saccharomyces cerevisiae YJL176C SWI3 Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
LALA0_S11e03884g	similar to uniprot|P39005 Saccharomyces cerevisiae YJL174W KRE9 Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
LALA0_S11e03906g	similar to uniprot|P26755 Saccharomyces cerevisiae YJL173C RFA3 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
LALA0_S11e03928g	similar to uniprot|P27614 Saccharomyces cerevisiae YJL172W CPS1 Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
LALA0_S11e03950g	similar to uniprot|P06783 Saccharomyces cerevisiae YKL178C STE3 Receptor for a factor pheromone, couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR
LALA0_S11e03972g	similar to uniprot|P46992 Saccharomyces cerevisiae YJL171C GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein
LALA0_S11e03994g	weakly similar to uniprot|P46993 Saccharomyces cerevisiae YJL170C ASG7 Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor
LALA0_S11e04016g	similar to uniprot|P46995 Saccharomyces cerevisiae YJL168C SET2 Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
LALA0_S11e04038g	similar to uniprot|P34239 Saccharomyces cerevisiae YKL176C LST4 Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
LALA0_S11e04060g	similar to uniprot|P34240 Saccharomyces cerevisiae YKL175W ZRT3 Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency
LALA0_S11e04082g	similar to uniprot|P36029 Saccharomyces cerevisiae YKL174C TPO5 Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
LALA0_S11e04104g	similar to uniprot|P36048 Saccharomyces cerevisiae YKL173W SNU114 GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
LALA0_S11e04126g	similar to uniprot|P36049 Saccharomyces cerevisiae YKL172W EBP2 Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
LALA0_S11e04148g	highly similar to uniprot|P08524 Saccharomyces cerevisiae YJL167W ERG20 Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
LALA0_S11e04170g	highly similar to uniprot|P08525 Saccharomyces cerevisiae YJL166W QCR8 Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
LALA0_S11e04192g	weakly similar to uniprot|P36003 Saccharomyces cerevisiae YKL171W NNK1 Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
LALA0_S11e04214g	highly similar to uniprot|P35996 Saccharomyces cerevisiae YKL170W MRPL38 Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels
LALA0_S11e04236g	similar to uniprot|P36004 Saccharomyces cerevisiae YKL168C (ohnolog of YJL165C) KKQ8 Putative serine/threonine protein kinase with unknown cellular role
LALA0_S11e04258g	similar to Lachancea thermotolerans KLTH0F05082g hypothetical protein
LALA0_S11e04280g	similar to uniprot|P32388 Saccharomyces cerevisiae YKL167C MRP49 Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation
LALA0_S11e04302g	similar to uniprot|P05986 Saccharomyces cerevisiae YKL166C (ohnolog of YJL164C) TPK3 cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase
LALA0_S11e04324g	similar to uniprot|P46996 Saccharomyces cerevisiae YJL163C Putative protein of unknown function
LALA0_S11e04346g	highly similar to uniprot|P36051 Saccharomyces cerevisiae YKL165C MCD4 Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
LALA0_S11e04368g	weakly similar to uniprot|P46997 Saccharomyces cerevisiae YJL162C JJJ2 Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
LALA0_S11e04456g	weakly similar to uniprot|P46998 Saccharomyces cerevisiae YJL161W FMP33 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S11e04478g	similar to uniprot|Q03180 Saccharomyces cerevisiae YKL163W (ohnolog of YJL159W) PIR3 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
LALA0_S11e04500g	similar to uniprot|Q03180 Saccharomyces cerevisiae YKL163W (ohnolog of YJL159W) PIR3 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
LALA0_S11e04544g	similar to uniprot|P40471 Saccharomyces cerevisiae YIL124W AYR1 NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
LALA0_S11e04566g	similar to uniprot|Q03180 Saccharomyces cerevisiae YKL163W (ohnolog of YJL159W) PIR3 O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
LALA0_S11e04588g	similar to uniprot|C5DKK5 Lachancea thermotolerans KLTH0F05478g hypothetical protein
LALA0_S11e04610g	similar to uniprot|P47002 Saccharomyces cerevisiae YJL156C SSY5 Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p
LALA0_S11e04632g	highly similar to uniprot|P32604 Saccharomyces cerevisiae YJL155C FBP26 Fructose-2,6-bisphosphatase, required for glucose metabolism
LALA0_S11e04654g	similar to uniprot|P34110 Saccharomyces cerevisiae YJL154C VPS35 Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval
LALA0_S11e04676g	similar to uniprot|P00431 Saccharomyces cerevisiae YKR066C CCP1 Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
LALA0_S11e04698g	similar to uniprot|P36147 Saccharomyces cerevisiae YKR065C PAM17 Constituent of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 complex
LALA0_S11e04720g	similar to uniprot|P14359 Saccharomyces cerevisiae YJL151C SNA3 Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
LALA0_S11e04742g	similar to uniprot|P47005 Saccharomyces cerevisiae YJL149W DAS1 Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
LALA0_S11e04764g	weakly similar to uniprot|P36023 Saccharomyces cerevisiae YKR064W OAF3 Zinc cluster protein; regulates transcription in response to oleate levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S11e04786g	weakly similar to uniprot|P36146 Saccharomyces cerevisiae YKR063C LAS1 Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability
LALA0_S11e04808g	some similarities with uniprot|P47006 Saccharomyces cerevisiae YJL148W RPA34 RNA polymerase I subunit A34.5
LALA0_S11e04830g	similar to uniprot|P36145 Saccharomyces cerevisiae YKR062W TFA2 TFIIE small subunit, involved in RNA polymerase II transcription initiation
LALA0_S11e04852g	weakly similar to uniprot|P47007 Saccharomyces cerevisiae YJL147C Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
LALA0_S11e04874g	weakly similar to uniprot|P46958 Saccharomyces cerevisiae YJL146W IDS2 Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
LALA0_S11e04896g	similar to uniprot|P47008 Saccharomyces cerevisiae YJL145W SFH5 Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p
LALA0_S11e04918g	highly similar to uniprot|P32451 Saccharomyces cerevisiae YGR286C BIO2 Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
LALA0_S11e04940g	similar to uniprot|C5DKM6 Lachancea thermotolerans KLTH0F05940g hypothetical protein
LALA0_S11e04962g	highly similar to uniprot|P39515 Saccharomyces cerevisiae YJL143W TIM17 Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
LALA0_S11e04984g	similar to uniprot|P14680 Saccharomyces cerevisiae YJL141C YAK1 Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose
LALA0_S11e05006g	similar to uniprot|P20433 Saccharomyces cerevisiae YJL140W RPB4 RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
LALA0_S11e05028g	similar to uniprot|P33550 Saccharomyces cerevisiae YKR061W (ohnolog of YJL139C) KTR2 Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
LALA0_S11e05050g	similar to uniprot|P36144 Saccharomyces cerevisiae YKR060W UTP30 Subunit of U3-containing 90S preribosome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
LALA0_S11e05072g	highly similar to uniprot|P10081 Saccharomyces cerevisiae YJL138C (ohnolog of YKR059W) TIF2 Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
LALA0_S11e05094g	weakly similar to uniprot|P47011 Saccharomyces cerevisiae YJL137C (ohnolog of YKR058W) GLG2 Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin
LALA0_S11e05116g	highly similar to uniprot|P05760 Saccharomyces cerevisiae YJL136C (ohnolog of YKR057W) RPS21B Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
LALA0_S11e05138g	similar to uniprot|P33753 Saccharomyces cerevisiae YKR056W TRM2 tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
LALA0_S11e05160g	similar to uniprot|Q00246 Saccharomyces cerevisiae YKR055W RHO4 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
LALA0_S11e05182g	similar to uniprot|P36022 Saccharomyces cerevisiae YKR054C DYN1 Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
LALA0_S11e05204g	similar to uniprot|P47013 Saccharomyces cerevisiae YJL134W (ohnolog of YKR053C) LCB3 Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids
LALA0_S11e05226g	similar to uniprot|P10566 Saccharomyces cerevisiae YJL133W (ohnolog of YKR052C) MRS3 Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs4p; active under low-iron conditions; may transport other cations
LALA0_S11e05248g	similar to uniprot|P36142 Saccharomyces cerevisiae YKR051W Putative protein of unknown function
LALA0_S11e05270g	similar to uniprot|P47014 Saccharomyces cerevisiae YJL132W Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
LALA0_S11e05292g	similar to uniprot|P47015 Saccharomyces cerevisiae YJL131C AIM23 Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss
LALA0_S11e05314g	highly similar to uniprot|P07259 Saccharomyces cerevisiae YJL130C URA2 Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
LALA0_S11e05336g	some similarities with uniprot|P12685 Saccharomyces cerevisiae YJL129C (ohnolog of YKR050W) TRK1 Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation
LALA0_S11e05358g	similar to uniprot|P08018 Saccharomyces cerevisiae YJL128C PBS2 MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition
LALA0_S11e05380g	similar to uniprot|Q3E828 Saccharomyces cerevisiae YJL127C-B Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
LALA0_S11e05402g	similar to uniprot|C5DGT5 Lachancea thermotolerans KLTH0D08118g hypothetical protein
LALA0_S11e05424g	similar to uniprot|P35208 Saccharomyces cerevisiae YJL127C SPT10 Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box
LALA0_S12e00100g	some similarities with uniprot|Q02207 Saccharomyces cerevisiae YKR009C FOX2 Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
LALA0_S12e00122g	some similarities with uniprot|C5DFQ0 Lachancea thermotolerans KLTH0D16940g hypothetical protein
LALA0_S12e00144g	weakly similar to uniprot|C5DNS2 Lachancea thermotolerans KLTH0G19382g hypothetical protein
LALA0_S12e00166g	weakly similar to uniprot|Q04432 Saccharomyces cerevisiae YDR533C HSP31 Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
LALA0_S12e00188g	similar to uniprot|C5DDC7 Lachancea thermotolerans KLTH0B10164g hypothetical protein
LALA0_S12e00210g	some similarities with uniprot|Q7LHD1 Saccharomyces cerevisiae YDR134C YDR134C Putative uncharacterized cell wall protein
LALA0_S12e00232g	similar to uniprot|Q7LGU1 Saccharomyces cerevisiae YPL274W SAM3 High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
LALA0_S12e00254g	similar to uniprot|Q12525 Saccharomyces cerevisiae YLL062C (ohnolog of YPL273W) MHT1 S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
LALA0_S12e00276g	similar to uniprot|C5DKP4 Lachancea thermotolerans KLTH0F06380g hypothetical protein
LALA0_S12e00298g	similar to uniprot|Q2VQ77 Saccharomyces cerevisiae YPL092W SSU1 Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
LALA0_S12e00320g	weakly similar to uniprot|P32805 Saccharomyces cerevisiae YGL254W FZF1 Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers
LALA0_S12e00342g	similar to uniprot|P00724 Saccharomyces cerevisiae YIL162W SUC2 Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
LALA0_S12e00364g	similar to uniprot|P40988 Saccharomyces cerevisiae YMR319C FET4 Low-affinity Fe(II) transporter of the plasma membrane
LALA0_S12e00386g	highly similar to uniprot|Q04432 Saccharomyces cerevisiae YDR533C HSP31 Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
LALA0_S12e00474g	similar to uniprot|P25293 Saccharomyces cerevisiae YKR048C NAP1 Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2
LALA0_S12e00496g	weakly similar to uniprot|P36139 Saccharomyces cerevisiae YKR046C PET10 Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
LALA0_S12e00518g	weakly similar to uniprot|P36138 Saccharomyces cerevisiae YKR045C Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
LALA0_S12e00540g	similar to uniprot|P46956 Saccharomyces cerevisiae YJL117W PHO86 Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles
LALA0_S12e00562g	similar to uniprot|P36137 Saccharomyces cerevisiae YKR044W UIP5 Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates
LALA0_S12e00584g	highly similar to uniprot|P36136 Saccharomyces cerevisiae YKR043C Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus
LALA0_S12e00606g	weakly similar to uniprot|Q05947 Saccharomyces cerevisiae YLR224W F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
LALA0_S12e00628g	similar to uniprot|P46955 Saccharomyces cerevisiae YJL116C (ohnolog of YKR042W) NCA3 Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin
LALA0_S12e00672g	similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein
LALA0_S12e00694g	similar to uniprot|P32447 Saccharomyces cerevisiae YJL115W ASF1 Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
LALA0_S12e00716g	weakly similar to uniprot|P36134 Saccharomyces cerevisiae YKR041W Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking
LALA0_S12e00738g	similar to uniprot|P54199 Saccharomyces cerevisiae YDL028C MPS1 Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p
LALA0_S12e00760g	highly similar to uniprot|P32381 Saccharomyces cerevisiae YDL029W ARP2 Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
LALA0_S12e00782g	weakly similar to uniprot|Q7LHC7 Saccharomyces cerevisiae YDL027C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
LALA0_S12e00804g	similar to uniprot|Q99186 Saccharomyces cerevisiae YOL062C APM4 Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport
LALA0_S12e00826g	similar to uniprot|Q12265 Saccharomyces cerevisiae YOL061W PRS5 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
LALA0_S12e00848g	similar to uniprot|Q12100 Saccharomyces cerevisiae YDL025C RTK1 Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1
LALA0_S12e00870g	similar to uniprot|Q12296 Saccharomyces cerevisiae YOL060C MAM3 Protein required for normal mitochondrial morphology, has similarity to hemolysins
LALA0_S12e00892g	putative transposase of a hAT-like DNA transposon, degenerate;putative transposase of a hAT-like DNA transposon, degenerate
LALA0_S12e00958g	highly similar to uniprot|Q00055 Saccharomyces cerevisiae YDL022W (ohnolog of YOL059W) GPD1 NAD-dependentglycerol-3-phosphate dehydrogenase, key enzyme of glycerolsynthesis, essential for growth under osmotic stress;expression regulated by high-osmolarity glycerol responsepathway; homolog of Gpd2p
LALA0_S12e00980g	weakly similar to uniprot|P49017 Saccharomyces cerevisiae YML110C COQ5 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
LALA0_S12e01002g	weakly similar to uniprot|P25297 Saccharomyces cerevisiae YML123C PHO84 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
LALA0_S12e01024g	highly similar to uniprot|P22768 Saccharomyces cerevisiae YOL058W ARG1 Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
LALA0_S12e01046g	similar to uniprot|Q08225 Saccharomyces cerevisiae YOL057W Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers
LALA0_S12e01068g	similar to uniprot|Q12008 Saccharomyces cerevisiae YDL021W (ohnolog of YOL056W) GPM2 Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
LALA0_S12e01090g	weakly similar to uniprot|Q03465 Saccharomyces cerevisiae YDL020C RPN4 Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses
LALA0_S12e01112g	similar to uniprot|Q6B2F0 Saccharomyces cerevisiae YOL055C THI20 Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activities; involved in thiamine biosynthesis and degradation; in a gene family with THI21 and THI22; HMP-P kinase activity redundant with Thi21p
LALA0_S12e01134g	some similarities with uniprot|P53379 Saccharomyces cerevisiae YDR144C (ohnolog of YLR120C) MKC7 GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
LALA0_S12e01156g	similar to uniprot|Q07923 Saccharomyces cerevisiae YLR011W LOT6 FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
LALA0_S12e01178g	similar to uniprot|Q04511 Saccharomyces cerevisiae YML088W UFO1 F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
LALA0_S12e01200g	similar to uniprot|Q04516 Saccharomyces cerevisiae YML087C (ohnolog of YML125C) AIM33 Putative protein of unknown function, highly conserved across species and orthologous to human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss
LALA0_S12e01222g	similar to uniprot|P54783 Saccharomyces cerevisiae YML086C ALO1 D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
LALA0_S12e01244g	highly similar to uniprot|P09733 Saccharomyces cerevisiae YML085C (ohnolog of YML124C) TUB1 Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
LALA0_S12e01266g	highly similar to uniprot|P25297 Saccharomyces cerevisiae YML123C PHO84 High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
LALA0_S12e01288g	similar to uniprot|C5DKT0 Lachancea thermotolerans KLTH0F07238g hypothetical protein
LALA0_S12e01310g	similar to uniprot|P29704 Saccharomyces cerevisiae YHR190W ERG9 Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
LALA0_S12e01354g	similar to uniprot|P38876 Saccharomyces cerevisiae YHR189W PTH1 One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium
LALA0_S12e01376g	highly similar to uniprot|Q00582 Saccharomyces cerevisiae YML121W GTR1 Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
LALA0_S12e01398g	highly similar to uniprot|P32340 Saccharomyces cerevisiae YML120C NDI1 NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
LALA0_S12e01420g	highly similar to uniprot|P39987 Saccharomyces cerevisiae YEL030W (ohnolog of YJR045C) ECM10 Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations
LALA0_S12e01442g	similar to uniprot|P47111 Saccharomyces cerevisiae YJR044C VPS55 Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)
LALA0_S12e01486g	similar to uniprot|Q6Q5S5 Saccharomyces cerevisiae YDR313C PIB1 RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
LALA0_S12e01508g	similar to uniprot|P38789 Saccharomyces cerevisiae YHR066W (ohnolog of YDR312W) SSF1 Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family
LALA0_S12e01530g	highly similar to uniprot|P38712 Saccharomyces cerevisiae YHR065C RRP3 Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
LALA0_S12e01552g	similar to uniprot|P32776 Saccharomyces cerevisiae YDR311W TFB1 Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators
LALA0_S12e01574g	highly similar to uniprot|P38788 Saccharomyces cerevisiae YHR064C SSZ1 Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
LALA0_S12e01596g	similar to uniprot|P38787 Saccharomyces cerevisiae YHR063C PAN5 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
LALA0_S12e01618g	weakly similar to uniprot|P46676 Saccharomyces cerevisiae YDR310C SUM1 Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
LALA0_S12e01640g	similar to uniprot|P38786 Saccharomyces cerevisiae YHR062C RPP1 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
LALA0_S12e01662g	weakly similar to uniprot|C5DKT5 Lachancea thermotolerans KLTH0F07348g hypothetical protein
LALA0_S12e01684g	weakly similar to uniprot|P38785 Saccharomyces cerevisiae YHR061C (ohnolog of YDR309C) GIC1 Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain
LALA0_S12e01706g	similar to uniprot|P38784 Saccharomyces cerevisiae YHR060W VMA22 Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
LALA0_S12e01728g	similar to uniprot|P47822 Saccharomyces cerevisiae YDR308C SRB7 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
LALA0_S12e01750g	weakly similar to uniprot|Q06644 Saccharomyces cerevisiae YDR307W Putative protein of unknown function
LALA0_S12e01772g	similar to uniprot|G8ZRR4 Torulaspora delbrueckii TDEL_0C03170 hypothetical protein
LALA0_S12e01816g	similar to uniprot|Q06640 Saccharomyces cerevisiae YDR306C F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
LALA0_S12e01838g	similar to uniprot|P49775 Saccharomyces cerevisiae YDR305C HNT2 Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins
LALA0_S12e01860g	similar to uniprot|P38783 Saccharomyces cerevisiae YHR059W FYV4 Protein of unknown function, required for survival upon exposure to K1 killer toxin
LALA0_S12e01882g	similar to uniprot|P45976 Saccharomyces cerevisiae YJR093C FIP1 Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
LALA0_S12e01904g	weakly similar to uniprot|P47136 Saccharomyces cerevisiae YJR092W BUD4 Involved in bud-site selection and required for the axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; required for the formation of a double septin ring, and generally for the organization of septin structures; potential Cdc28p substrate
LALA0_S12e01948g	similar to uniprot|Q12221 Saccharomyces cerevisiae YPR042C (ohnolog of YJR091C) PUF2 Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins
LALA0_S12e01970g	similar to uniprot|P24814 Saccharomyces cerevisiae YJR090C GRR1 F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
LALA0_S12e01992g	weakly similar to uniprot|P47134 Saccharomyces cerevisiae YJR089W BIR1 Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension
LALA0_S12e02014g	highly similar to uniprot|P38431 Saccharomyces cerevisiae YPR041W TIF5 Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
LALA0_S12e02036g	similar to uniprot|P47133 Saccharomyces cerevisiae YJR088C EMC2 Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response
LALA0_S12e02058g	similar to uniprot|Q12199 Saccharomyces cerevisiae YPR040W TIP41 Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway
LALA0_S12e02080g	similar to uniprot|Q12284 Saccharomyces cerevisiae YPR037C ERV2 Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
LALA0_S12e02102g	similar to uniprot|P18852 Saccharomyces cerevisiae YJR086W STE18 G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling
LALA0_S12e02124g	similar to uniprot|P47131 Saccharomyces cerevisiae YJR085C Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S12e02146g	similar to uniprot|I6ND86 Eremothecium cymbalariae Ecym_5263 hypothetical protein
LALA0_S12e02168g	similar to uniprot|P47130 Saccharomyces cerevisiae YJR084W Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome
LALA0_S12e02190g	weakly similar to uniprot|P47129 Saccharomyces cerevisiae YJR083C ACF4 Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
LALA0_S12e02212g	similar to uniprot|P41807 Saccharomyces cerevisiae YPR036W VMA13 Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
LALA0_S12e02234g	highly similar to uniprot|P32288 Saccharomyces cerevisiae YPR035W GLN1 Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation
LALA0_S12e02256g	some similarities with uniprot|P36151 Saccharomyces cerevisiae YKR070W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S12e02278g	similar to uniprot|Q7LIE3 Saccharomyces cerevisiae YDR214W AHA1 Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock
LALA0_S12e02300g	similar to uniprot|Q12151 Saccharomyces cerevisiae YDR213W (ohnolog of YLR228C) UPC2 Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion
LALA0_S12e02322g	highly similar to uniprot|P12612 Saccharomyces cerevisiae YDR212W TCP1 Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
LALA0_S12e02344g	highly similar to uniprot|P19073 Saccharomyces cerevisiae YLR229C CDC42 Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
LALA0_S12e02366g	similar to uniprot|P32501 Saccharomyces cerevisiae YDR211W GCD6 Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
LALA0_S12e02410g	some similarities with uniprot|C5DD14 Lachancea thermotolerans KLTH0B07502g hypothetical protein
LALA0_S12e02432g	similar to uniprot|P38994 Saccharomyces cerevisiae YDR208W MSS4 Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
LALA0_S12e02454g	similar to uniprot|P53110 Saccharomyces cerevisiae YGL159W Putative protein of unknown function; deletion mutant has no detectable phenotype
LALA0_S12e02476g	similar to uniprot|Q01896 Saccharomyces cerevisiae YDR039C ENA2 P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux
LALA0_S12e02498g	similar to uniprot|Q05979 Saccharomyces cerevisiae YLR231C BNA5 Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
LALA0_S12e02520g	similar to uniprot|P38124 Saccharomyces cerevisiae YBR008C FLR1 Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin
LALA0_S12e02542g	weakly similar to uniprot|P39001 Saccharomyces cerevisiae YDR207C UME6 Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
LALA0_S12e02564g	weakly similar to uniprot|Q03466 Saccharomyces cerevisiae YDR206W (ohnolog of YLR233C) EBS1 Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
LALA0_S12e02586g	similar to uniprot|P13099 Saccharomyces cerevisiae YLR234W TOP3 DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination
LALA0_S12e02608g	similar to uniprot|Q03455 Saccharomyces cerevisiae YDR205W MSC2 Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
LALA0_S12e02630g	highly similar to uniprot|P80210 Saccharomyces cerevisiae YNL220W ADE12 Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
LALA0_S12e02652g	similar to uniprot|P53868 Saccharomyces cerevisiae YNL219C ALG9 Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
LALA0_S12e02674g	similar to uniprot|P19881 Saccharomyces cerevisiae YDL236W PHO13 Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
LALA0_S12e02696g	similar to uniprot|P40151 Saccharomyces cerevisiae YNL218W MGS1 Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)
LALA0_S12e02718g	similar to uniprot|Q07688 Saccharomyces cerevisiae YDL235C YPD1 Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
LALA0_S12e02740g	similar to uniprot|P40152 Saccharomyces cerevisiae YNL217W Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate
LALA0_S12e02762g	similar to uniprot|P11938 Saccharomyces cerevisiae YNL216W RAP1 DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure
LALA0_S12e02784g	similar to uniprot|P48365 Saccharomyces cerevisiae YDL234C GYP7 GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
LALA0_S12e02806g	similar to uniprot|P40154 Saccharomyces cerevisiae YNL215W IES2 Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions
LALA0_S12e02828g	some similarities with uniprot|Q07684 Saccharomyces cerevisiae YDL233W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene
LALA0_S12e02850g	weakly similar to uniprot|P40155 Saccharomyces cerevisiae YNL214W PEX17 Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis
LALA0_S12e02872g	similar to uniprot|P40156 Saccharomyces cerevisiae YNL213C RRG9 Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S12e02894g	similar to uniprot|P40157 Saccharomyces cerevisiae YNL212W VID27 Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
LALA0_S12e02916g	similar to uniprot|P53869 Saccharomyces cerevisiae YNL211C Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
LALA0_S12e02938g	similar to uniprot|Q99380 Saccharomyces cerevisiae YDL232W OST4 Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex
LALA0_S12e02960g	similar to uniprot|Q07660 Saccharomyces cerevisiae YDL231C BRE4 Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
LALA0_S12e02982g	similar to uniprot|P25044 Saccharomyces cerevisiae YDL230W PTP1 Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
LALA0_S12e03004g	weakly similar to uniprot|P16523 Saccharomyces cerevisiae YNL210W MER1 Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22
LALA0_S12e03026g	highly similar to uniprot|P11484 Saccharomyces cerevisiae YDL229W (ohnolog of YNL209W) SSB1 Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p
LALA0_S12e03048g	highly similar to uniprot|P40160 Saccharomyces cerevisiae YNL207W RIO2 Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
LALA0_S12e03070g	similar to uniprot|P40161 Saccharomyces cerevisiae YNL206C RTT106 Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition
LALA0_S12e03092g	similar to uniprot|P35197 Saccharomyces cerevisiae YDL226C (ohnolog of YNL204C) GCS1 ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
LALA0_S12e03114g	highly similar to uniprot|P32573 Saccharomyces cerevisiae YNL202W SPS19 Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
LALA0_S12e03136g	similar to uniprot|P40164 Saccharomyces cerevisiae YNL201C PSY2 Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3
LALA0_S12e03158g	highly similar to uniprot|P40165 Saccharomyces cerevisiae YNL200C Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S12e03180g	weakly similar to uniprot|Q01722 Saccharomyces cerevisiae YNL199C GCR2 Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
LALA0_S12e03202g	similar to uniprot|Q07657 Saccharomyces cerevisiae YDL225W SHS1 One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
LALA0_S12e03224g	similar to uniprot|Q07655 Saccharomyces cerevisiae YDL224C (ohnolog of YNL197C) WHI4 Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
LALA0_S12e03246g	weakly similar to uniprot|C5DCZ5 Lachancea thermotolerans KLTH0B07062g hypothetical protein
LALA0_S12e03268g	similar to uniprot|Q07651 Saccharomyces cerevisiae YDL222C (ohnolog of YNL194C) FMP45 Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
LALA0_S12e03290g	weakly similar to uniprot|P32797 Saccharomyces cerevisiae YDL220C CDC13 Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping
LALA0_S12e03312g	similar to uniprot|P53870 Saccharomyces cerevisiae YNL193W Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
LALA0_S12e03334g	similar to uniprot|P08004 Saccharomyces cerevisiae YNL192W CHS1 Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor
LALA0_S12e03356g	highly similar to uniprot|Q07648 Saccharomyces cerevisiae YDL219W DTD1 D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
LALA0_S12e03378g	highly similar to uniprot|P53871 Saccharomyces cerevisiae YNL191W DUG3 Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
LALA0_S12e03400g	weakly similar to uniprot|Q07629 Saccharomyces cerevisiae YDL218W Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
LALA0_S12e03422g	similar to uniprot|P53872 Saccharomyces cerevisiae YNL190W Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
LALA0_S12e03444g	highly similar to uniprot|Q02821 Saccharomyces cerevisiae YNL189W SRP1 Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
LALA0_S12e03466g	weakly similar to uniprot|P11927 Saccharomyces cerevisiae YNL188W KAR1 Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
LALA0_S12e03488g	highly similar to uniprot|Q12328 Saccharomyces cerevisiae YDL217C TIM22 Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
LALA0_S12e03510g	weakly similar to uniprot|P53873 Saccharomyces cerevisiae YNL187W SWT21 Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats
LALA0_S12e03532g	weakly similar to uniprot|Q12468 Saccharomyces cerevisiae YDL216C RRI1 Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling
LALA0_S12e03554g	similar to uniprot|P33327 Saccharomyces cerevisiae YDL215C GDH2 NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
LALA0_S12e03576g	similar to uniprot|P53874 Saccharomyces cerevisiae YNL186W UBP10 Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
LALA0_S12e03598g	highly similar to uniprot|P53875 Saccharomyces cerevisiae YNL185C MRPL19 Mitochondrial ribosomal protein of the large subunit
LALA0_S12e03620g	similar to uniprot|Q12310 Saccharomyces cerevisiae YDL214C (ohnolog of YNL183C) PRR2 Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
LALA0_S12e03642g	similar to uniprot|Q07623 Saccharomyces cerevisiae YDL213C NOP6 rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
LALA0_S12e03664g	similar to Lachancea thermotolerans KLTH0B06908g hypothetical protein
LALA0_S12e03686g	similar to uniprot|P53877 Saccharomyces cerevisiae YNL182C IPI3 Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
LALA0_S12e03708g	similar to uniprot|P53878 Saccharomyces cerevisiae YNL181W Putative oxidoreductase; required for cell viability
LALA0_S12e03730g	similar to uniprot|P53879 Saccharomyces cerevisiae YNL180C RHO5 Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
LALA0_S12e03752g	some similarities with uniprot|P29029 Saccharomyces cerevisiae YLR286C CTS1 Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
LALA0_S12e03774g	highly similar to uniprot|P05750 Saccharomyces cerevisiae YNL178W RPS3 Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
LALA0_S12e03796g	similar to uniprot|Q02774 Saccharomyces cerevisiae YDL212W SHR3 Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
LALA0_S12e03818g	similar to uniprot|P53881 Saccharomyces cerevisiae YNL177C MRPL22 Mitochondrial ribosomal protein of the large subunit
LALA0_S12e03840g	similar to Lachancea thermotolerans KLTH0B06908g hypothetical protein
LALA0_S12e03862g	similar to uniprot|P53883 Saccharomyces cerevisiae YNL175C NOP13 Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM)
LALA0_S12e03884g	some similarities with uniprot|P38845 Saccharomyces cerevisiae YHR146W (ohnolog of YNL173C) CRP1 Protein that binds to cruciform DNA structures
LALA0_S12e03928g	similar to uniprot|P53886 Saccharomyces cerevisiae YNL172W APC1 Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis
LALA0_S12e03950g	similar to uniprot|P39006 Saccharomyces cerevisiae YNL169C PSD1 Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
LALA0_S12e03972g	similar to uniprot|P06773 Saccharomyces cerevisiae YHR144C DCD1 Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
LALA0_S12e03994g	weakly similar to uniprot|Q02100 Saccharomyces cerevisiae YNL167C SKO1 Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses
LALA0_S13e00100g	some similarities with uniprot|P08068 Saccharomyces cerevisiae YIR019C MUC1 GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
LALA0_S13e00122g	weakly similar to uniprot|P36033 Saccharomyces cerevisiae YKL220C FRE2 Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
LALA0_S13e00144g	similar to uniprot|P07257 Saccharomyces cerevisiae YPR191W QCR2 Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
LALA0_S13e00166g	similar to uniprot|P32349 Saccharomyces cerevisiae YPR190C RPC82 RNA polymerase III subunit C82
LALA0_S13e00188g	similar to uniprot|P17883 Saccharomyces cerevisiae YPR189W SKI3 Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
LALA0_S13e00210g	similar to uniprot|Q06580 Saccharomyces cerevisiae YPR188C MLC2 Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring
LALA0_S13e00232g	highly similar to uniprot|P20435 Saccharomyces cerevisiae YPR187W RPO26 RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
LALA0_S13e00254g	similar to uniprot|P39933 Saccharomyces cerevisiae YPR186C PZF1 Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA
LALA0_S13e00276g	similar to uniprot|Q06628 Saccharomyces cerevisiae YPR185W ATG13 Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
LALA0_S13e00298g	highly similar to uniprot|O93808 Saccharomyces cerevisiae YPR184W GDB1 Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p
LALA0_S13e00320g	highly similar to uniprot|P14020 Saccharomyces cerevisiae YPR183W DPM1 Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
LALA0_S13e00342g	some similarities with uniprot|P54999 Saccharomyces cerevisiae YPR182W SMX3 Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
LALA0_S13e00364g	similar to uniprot|P41733 Saccharomyces cerevisiae YLR459W GAB1 GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI
LALA0_S13e00386g	highly similar to uniprot|P15303 Saccharomyces cerevisiae YPR181C SEC23 GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport
LALA0_S13e00408g	similar to uniprot|Q06624 Saccharomyces cerevisiae YPR180W AOS1 Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
LALA0_S13e00430g	similar to uniprot|Q06623 Saccharomyces cerevisiae YPR179C HDA3 Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p
LALA0_S13e00452g	similar to uniprot|P20053 Saccharomyces cerevisiae YPR178W PRP4 Splicing factor, component of the U4/U6-U5 snRNP complex
LALA0_S13e00474g	highly similar to uniprot|P20133 Saccharomyces cerevisiae YPR176C BET2 Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
LALA0_S13e00496g	similar to uniprot|P24482 Saccharomyces cerevisiae YPR175W DPB2 Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
LALA0_S13e00518g	weakly similar to uniprot|Q06616 Saccharomyces cerevisiae YPR174C (ohnolog of YLR457C) Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study
LALA0_S13e00540g	highly similar to uniprot|P52917 Saccharomyces cerevisiae YPR173C VPS4 AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
LALA0_S13e00562g	similar to uniprot|Q06608 Saccharomyces cerevisiae YPR172W (ohnolog of YLR456W) Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
LALA0_S13e00584g	similar to uniprot|Q06188 Saccharomyces cerevisiae YLR455W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
LALA0_S13e00606g	weakly similar to uniprot|P53322 Saccharomyces cerevisiae YGR260W TNA1 High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
LALA0_S13e00628g	weakly similar to uniprot|Q06604 Saccharomyces cerevisiae YPR171W BSP1 Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
LALA0_S13e00650g	highly similar to uniprot|P0C5R9 Saccharomyces cerevisiae YPR170W-B Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
LALA0_S13e00694g	highly similar to uniprot|P07280 Saccharomyces cerevisiae YOL121C (ohnolog of YNL302C) RPS19A Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp
LALA0_S13e00716g	highly similar to uniprot|P07279 Saccharomyces cerevisiae YOL120C (ohnolog of YNL301C) RPL18A Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation
LALA0_S13e00738g	similar to uniprot|Q08268 Saccharomyces cerevisiae YOL119C MCH4 Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
LALA0_S13e00760g	weakly similar to uniprot|P38013 Saccharomyces cerevisiae YLR109W AHP1 Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
LALA0_S13e00782g	weakly similar to uniprot|Q12348 Saccharomyces cerevisiae YOL117W RRI2 Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response
LALA0_S13e00804g	some similarities with uniprot|P48560 Saccharomyces cerevisiae YNL300W TOS6 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
LALA0_S13e00826g	similar to uniprot|P53632 Saccharomyces cerevisiae YOL115W (ohnolog of YNL299W) PAP2 Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p
LALA0_S13e00848g	similar to uniprot|Q12322 Saccharomyces cerevisiae YOL114C Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene
LALA0_S13e00870g	similar to uniprot|Q12469 Saccharomyces cerevisiae YOL113W (ohnolog of YNL298W) SKM1 Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth
LALA0_S13e00892g	similar to uniprot|P48563 Saccharomyces cerevisiae YNL297C MON2 Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins
LALA0_S13e00936g	similar to uniprot|P48564 Saccharomyces cerevisiae YNL295W Putative protein of unknown function
LALA0_S13e00958g	similar to uniprot|P48565 Saccharomyces cerevisiae YNL294C RIM21 Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH
LALA0_S13e00980g	similar to uniprot|Q12317 Saccharomyces cerevisiae YOL112W (ohnolog of YNL293W) MSB4 GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization
LALA0_S13e01002g	similar to uniprot|Q12285 Saccharomyces cerevisiae YOL111C MDY2 Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
LALA0_S13e01024g	similar to uniprot|P41912 Saccharomyces cerevisiae YOL110W SHR5 Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization
LALA0_S13e01046g	similar to uniprot|P48567 Saccharomyces cerevisiae YNL292W PUS4 Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
LALA0_S13e01068g	similar to uniprot|P41821 Saccharomyces cerevisiae YNL291C MID1 N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
LALA0_S13e01112g	highly similar to uniprot|P38629 Saccharomyces cerevisiae YNL290W RFC3 Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
LALA0_S13e01134g	similar to uniprot|P24867 Saccharomyces cerevisiae YNL289W PCL1 Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth
LALA0_S13e01156g	highly similar to uniprot|C5DBD3 Lachancea thermotolerans KLTH0A01628g hypothetical protein
LALA0_S13e01178g	hypothetical protein
LALA0_S13e01200g	similar to uniprot|P53829 Saccharomyces cerevisiae YNL288W CAF40 Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
LALA0_S13e01222g	highly similar to uniprot|P32074 Saccharomyces cerevisiae YNL287W SEC21 Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
LALA0_S13e01244g	similar to uniprot|P53830 Saccharomyces cerevisiae YNL286W CUS2 Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)
LALA0_S13e01310g	weakly similar to uniprot|P43596 Saccharomyces cerevisiae YFR013W (ohnolog of YOL017W) IOC3 Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing
LALA0_S13e01332g	highly similar to uniprot|C5E390 Lachancea thermotolerans KLTH0H11308g hypothetical protein
LALA0_S13e01354g	similar to uniprot|P43606 Saccharomyces cerevisiae YFR029W PTR3 Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
LALA0_S13e01376g	similar to uniprot|P47051 Saccharomyces cerevisiae YJL046W AIM22 Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss
LALA0_S13e01398g	similar to uniprot|P38336 Saccharomyces cerevisiae YBR257W POP4 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
LALA0_S13e01420g	weakly similar to uniprot|P38337 Saccharomyces cerevisiae YBR258C SHG1 Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
LALA0_S13e01442g	weakly similar to uniprot|P38338 Saccharomyces cerevisiae YBR259W (ohnolog of YJL047C) Putative protein of unknown function; YBR259W is not an essential gene
LALA0_S13e01464g	weakly similar to uniprot|P38338 Saccharomyces cerevisiae YBR259W (ohnolog of YJL047C) Putative protein of unknown function; YBR259W is not an essential gene
LALA0_S13e01486g	similar to uniprot|P38339 Saccharomyces cerevisiae YBR260C RGD1 GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
LALA0_S13e01508g	highly similar to uniprot|P38340 Saccharomyces cerevisiae YBR261C TAE1 AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm
LALA0_S13e01530g	similar to uniprot|P38341 Saccharomyces cerevisiae YBR262C AIM5 Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S13e01552g	highly similar to uniprot|P38353 Saccharomyces cerevisiae YBR283C SSH1 Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
LALA0_S13e01574g	similar to uniprot|P36526 Saccharomyces cerevisiae YBR282W MRPL27 Mitochondrial ribosomal protein of the large subunit
LALA0_S13e01596g	similar to uniprot|P40362 Saccharomyces cerevisiae YJL069C UTP18 Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
LALA0_S13e01618g	similar to uniprot|P38149 Saccharomyces cerevisiae YBR281C DUG2 Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
LALA0_S13e01640g	similar to uniprot|P38352 Saccharomyces cerevisiae YBR280C SAF1 F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
LALA0_S13e01662g	similar to uniprot|P40363 Saccharomyces cerevisiae YJL068C Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
LALA0_S13e01684g	similar to uniprot|P38351 Saccharomyces cerevisiae YBR279W PAF1 Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; homolog of human PD2/hPAF1; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
LALA0_S13e01706g	weakly similar to uniprot|P40364 Saccharomyces cerevisiae YJL066C MPM1 Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches
LALA0_S13e01728g	some similarities with uniprot|P40366 Saccharomyces cerevisiae YJL065C (ohnolog of YBR278W) DLS1 Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing
LALA0_S13e01750g	weakly similar to uniprot|P38148 Saccharomyces cerevisiae YBR276C PPS1 Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
LALA0_S13e01772g	similar to uniprot|P53206 Saccharomyces cerevisiae YGR012W Putative cysteine synthase, localized to the mitochondrial outer membrane
LALA0_S13e01794g	similar to uniprot|P22353 Saccharomyces cerevisiae YJL063C MRPL8 Mitochondrial ribosomal protein of the large subunit
LALA0_S13e01816g	similar to uniprot|Q3E7B2 Saccharomyces cerevisiae YJL062W-A COA3 Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
LALA0_S13e01838g	similar to uniprot|P38342 Saccharomyces cerevisiae YBR265W TSC10 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
LALA0_S13e01860g	similar to uniprot|P38344 Saccharomyces cerevisiae YBR267W REI1 Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
LALA0_S13e01882g	similar to uniprot|P40367 Saccharomyces cerevisiae YJL062W LAS21 Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity
LALA0_S13e01904g	similar to uniprot|P36532 Saccharomyces cerevisiae YBR268W MRPL37 Mitochondrial ribosomal protein of the large subunit
LALA0_S13e01926g	weakly similar to uniprot|P40368 Saccharomyces cerevisiae YJL061W NUP82 Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Gle2p, Nup159p, Nsp1p, and Nup116p and is required for proper localization of Nup116p in the NPC
LALA0_S13e01948g	similar to uniprot|P38345 Saccharomyces cerevisiae YBR269C FMP21 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S13e01970g	similar to uniprot|Q08287 Saccharomyces cerevisiae YOL144W NOP8 Nucleolar protein required for 60S ribosomal subunit biogenesis
LALA0_S13e01992g	highly similar to uniprot|P50861 Saccharomyces cerevisiae YOL143C RIB4 Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin
LALA0_S13e02014g	similar to uniprot|P42834 Saccharomyces cerevisiae YNL328C MDJ2 Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
LALA0_S13e02036g	similar to uniprot|P33760 Saccharomyces cerevisiae YNL329C PEX6 AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol
LALA0_S13e02058g	highly similar to uniprot|P32561 Saccharomyces cerevisiae YNL330C RPD3 Histone deacetylase; regulates transcription, silencing, and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members
LALA0_S13e02080g	weakly similar to uniprot|P42835 Saccharomyces cerevisiae YNL327W EGT2 Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
LALA0_S13e02102g	similar to uniprot|P42836 Saccharomyces cerevisiae YNL326C PFA3 Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
LALA0_S13e02124g	similar to uniprot|Q08285 Saccharomyces cerevisiae YOL142W RRP40 Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3)
LALA0_S13e02146g	similar to uniprot|P42837 Saccharomyces cerevisiae YNL325C FIG4 Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain
LALA0_S13e02168g	similar to uniprot|Q08282 Saccharomyces cerevisiae YOL141W PPM2 AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
LALA0_S13e02190g	similar to uniprot|P46950 Saccharomyces cerevisiae YGR197C (ohnolog of YJR015W) SNG1 Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
LALA0_S13e02212g	similar to uniprot|P42838 Saccharomyces cerevisiae YNL323W LEM3 Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
LALA0_S13e02234g	highly similar to uniprot|P18544 Saccharomyces cerevisiae YOL140W ARG8 Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
LALA0_S13e02256g	similar to uniprot|P17260 Saccharomyces cerevisiae YNL322C KRE1 Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
LALA0_S13e02278g	similar to uniprot|P42839 Saccharomyces cerevisiae YNL321W VNX1 Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate
LALA0_S13e02300g	similar to uniprot|P07260 Saccharomyces cerevisiae YOL139C CDC33 Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p)
LALA0_S13e02322g	similar to uniprot|P42840 Saccharomyces cerevisiae YNL320W Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S13e02344g	similar to uniprot|Q92271 Saccharomyces cerevisiae YOL138C RTC1 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif
LALA0_S13e02366g	similar to uniprot|P40957 Saccharomyces cerevisiae YGL086W MAD1 Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
LALA0_S13e02388g	highly similar to uniprot|P53152 Saccharomyces cerevisiae YGL087C MMS2 Ubiquitin-conjugating enzyme variant involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p
LALA0_S13e02410g	highly similar to uniprot|Q06892 Saccharomyces cerevisiae YPL188W POS5 Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress
LALA0_S13e02432g	weakly similar to uniprot|P34163 Saccharomyces cerevisiae YKL140W TGL1 Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
LALA0_S13e02454g	similar to uniprot|P32435 Saccharomyces cerevisiae YGL089C (ohnolog of YPL187W) MF(ALPHA)2 Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
LALA0_S13e02476g	weakly similar to uniprot|Q08926 Saccharomyces cerevisiae YPL186C UIP4 Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
LALA0_S13e02498g	similar to uniprot|Q08925 Saccharomyces cerevisiae YPL184C MRN1 RNA-binding protein proposed to be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES)
LALA0_S13e02520g	weakly similar to uniprot|P53150 Saccharomyces cerevisiae YGL090W LIF1 Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
LALA0_S13e02542g	highly similar to uniprot|P52920 Saccharomyces cerevisiae YGL091C NBP35 Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases
LALA0_S13e02564g	weakly similar to uniprot|P49687 Saccharomyces cerevisiae YGL092W NUP145 Essential nucleoporin, subunit of the Nup84p subcomplex; catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p; the Nup84 subcomplex has a role in transcription elongation
LALA0_S13e02586g	weakly similar to uniprot|P53148 Saccharomyces cerevisiae YGL093W SPC105 Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
LALA0_S13e02608g	similar to uniprot|O14464 Saccharomyces cerevisiae YPL183W-A RTC6 Protein involved translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein encoded in the nucleus
LALA0_S13e02630g	similar to uniprot|Q08924 Saccharomyces cerevisiae YPL183C RTT10 Cytoplasmic protein with a role in regulation of Ty1 transposition
LALA0_S13e02652g	similar to uniprot|P53010 Saccharomyces cerevisiae YGL094C PAN2 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
LALA0_S13e02674g	weakly similar to uniprot|Q08921 Saccharomyces cerevisiae YPL180W TCO89 Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin
LALA0_S13e02696g	similar to uniprot|P38932 Saccharomyces cerevisiae YGL095C VPS45 Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
LALA0_S13e02718g	weakly similar to uniprot|Q6B1X3 Saccharomyces cerevisiae YPL181W CTI6 Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
LALA0_S13e02740g	similar to uniprot|P32945 Saccharomyces cerevisiae YPL179W PPQ1 Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors
LALA0_S13e02784g	highly similar to uniprot|Q08920 Saccharomyces cerevisiae YPL178W CBC2 Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
LALA0_S13e02806g	weakly similar to uniprot|P53147 Saccharomyces cerevisiae YGL096W (ohnolog of YPL177C) TOS8 Homeodomain-containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; similar to Cup9p transcription factor
LALA0_S13e02828g	hypothetical protein
LALA0_S13e02850g	weakly similar to uniprot|P33757 Saccharomyces cerevisiae YBR250W SPO23 Protein of unknown function; associates with meiosis-specific protein Spo1p
LALA0_S13e02872g	similar to uniprot|P38156 Saccharomyces cerevisiae YBR298C MAL31 Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C
LALA0_S13e02894g	similar to uniprot|P53051 Saccharomyces cerevisiae YGR287C IMA1 Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization; has specificity for isomaltose, palatinose, and methyl-alpha-glucoside; member of the IMA isomaltase family
LALA0_S13e02916g	highly similar to uniprot|P32449 Saccharomyces cerevisiae YBR249C ARO4 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
LALA0_S13e02938g	highly similar to uniprot|P33734 Saccharomyces cerevisiae YBR248C HIS7 Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
LALA0_S13e02960g	highly similar to uniprot|P21827 Saccharomyces cerevisiae YGL097W SRM1 Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
LALA0_S13e02982g	similar to uniprot|C5E2J1 Lachancea thermotolerans KLTH0H05412g hypothetical protein
LALA0_S13e03004g	highly similar to uniprot|P38333 Saccharomyces cerevisiae YBR247C ENP1 Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
LALA0_S13e03026g	similar to uniprot|P53146 Saccharomyces cerevisiae YGL098W USE1 Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
LALA0_S13e03048g	highly similar to uniprot|P53145 Saccharomyces cerevisiae YGL099W LSG1 Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
LALA0_S13e03070g	similar to uniprot|P38332 Saccharomyces cerevisiae YBR246W RRT2 Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype
LALA0_S13e03092g	similar to uniprot|P38144 Saccharomyces cerevisiae YBR245C ISW1 Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation
LALA0_S13e03114g	similar to uniprot|P40581 Saccharomyces cerevisiae YIR037W (ohnolog of YKL026C) HYR1 Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor
LALA0_S13e03136g	putative transposase of the Rover hAT-like DNA transposon, degenerate;putative transposase of the Rover hAT-like DNA transposon, degenerate
LALA0_S13e03158g	highly similar to uniprot|P53011 Saccharomyces cerevisiae YGL100W SEH1 Nuclear pore protein of the conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); part of the SEA (Seh1-associated) complex, a coatamer-related complex that associates dynamically with the vacuole; homologous to Sec13p; the Nup84 subcomplex has a role in transcription elongation
LALA0_S13e03180g	highly similar to uniprot|P07286 Saccharomyces cerevisiae YBR243C ALG7 UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
LALA0_S13e03202g	similar to uniprot|P53144 Saccharomyces cerevisiae YGL101W (ohnolog of YBR242W) Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
LALA0_S13e03224g	highly similar to uniprot|P02406 Saccharomyces cerevisiae YGL103W RPL28 Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
LALA0_S13e03246g	similar to uniprot|P53142 Saccharomyces cerevisiae YGL104C (ohnolog of YBR241C) VPS73 Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
LALA0_S13e03268g	weakly similar to uniprot|P38141 Saccharomyces cerevisiae YBR240C THI2 Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes
LALA0_S13e03290g	similar to uniprot|P46672 Saccharomyces cerevisiae YGL105W ARC1 Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
LALA0_S13e03312g	similar to uniprot|P38140 Saccharomyces cerevisiae YBR239C ERT1 Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition
LALA0_S13e03334g	highly similar to uniprot|P53141 Saccharomyces cerevisiae YGL106W MLC1 Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
LALA0_S13e03356g	similar to uniprot|P53140 Saccharomyces cerevisiae YGL107C (ohnolog of YBR238C) RMD9 Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
LALA0_S13e03378g	similar to uniprot|P53139 Saccharomyces cerevisiae YGL108C Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
LALA0_S13e03400g	similar to uniprot|P21372 Saccharomyces cerevisiae YBR237W PRP5 RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA
LALA0_S13e03422g	highly similar to uniprot|P32783 Saccharomyces cerevisiae YBR236C ABD1 Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
LALA0_S13e03444g	similar to uniprot|P38329 Saccharomyces cerevisiae YBR235W Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene
LALA0_S13e03466g	similar to uniprot|P53137 Saccharomyces cerevisiae YGL110C CUE3 Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
LALA0_S13e03488g	similar to uniprot|P53136 Saccharomyces cerevisiae YGL111W NSA1 Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
LALA0_S13e03510g	highly similar to uniprot|P38328 Saccharomyces cerevisiae YBR234C ARC40 Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
LALA0_S13e03532g	similar to uniprot|P69850 Saccharomyces cerevisiae YBR233W-A DAD3 Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
LALA0_S13e03554g	highly similar to uniprot|P53040 Saccharomyces cerevisiae YGL112C TAF6 Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
LALA0_S13e03576g	weakly similar to uniprot|P53135 Saccharomyces cerevisiae YGL113W SLD3 Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p
LALA0_S13e03598g	similar to uniprot|P38151 Saccharomyces cerevisiae YBR233W PBP2 RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length
LALA0_S13e03620g	similar to uniprot|P38326 Saccharomyces cerevisiae YBR231C SWC5 Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
LALA0_S13e03642g	similar to uniprot|P53134 Saccharomyces cerevisiae YGL114W Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
LALA0_S13e03664g	highly similar to uniprot|P12904 Saccharomyces cerevisiae YGL115W SNF4 Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis
LALA0_S13e03708g	similar to uniprot|P26309 Saccharomyces cerevisiae YGL116W CDC20 Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate
LALA0_S13e03730g	highly similar to uniprot|C5DIA2 Lachancea thermotolerans KLTH0E10912g hypothetical protein
LALA0_S13e03752g	similar to uniprot|C5DC79 Lachancea thermotolerans KLTH0B00836g hypothetical protein
LALA0_S13e03796g	similar to uniprot|P27697 Saccharomyces cerevisiae YGL119W (ohnolog of YBR230W-A) COQ8 Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis
LALA0_S13e03818g	highly similar to uniprot|P53131 Saccharomyces cerevisiae YGL120C PRP43 RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
LALA0_S14e00100g	similar to uniprot|I6NCR2 Eremothecium cymbalariae Ecym_5064 hypothetical protein
LALA0_S14e00122g	similar to uniprot|P39735 Saccharomyces cerevisiae YAL027W SAW1 Protein involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
LALA0_S14e00144g	highly similar to uniprot|P54885 Saccharomyces cerevisiae YOR323C PRO2 Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
LALA0_S14e00166g	similar to uniprot|P39524 Saccharomyces cerevisiae YAL026C DRS2 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
LALA0_S14e00188g	highly similar to uniprot|P10962 Saccharomyces cerevisiae YAL025C MAK16 Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
LALA0_S14e00210g	similar to uniprot|P07866 Saccharomyces cerevisiae YAL024C LTE1 Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
LALA0_S14e00232g	weakly similar to uniprot|P34758 Saccharomyces cerevisiae YOR329C SCD5 Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
LALA0_S14e00254g	weakly similar to uniprot|Q01090 Lachancea waltii pKW1_04 hypothetical protein
LALA0_S14e00276g	similar to uniprot|P15801 Saccharomyces cerevisiae YOR330C MIP1 Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; related to human POLG, which has been associated with mitochondrial diseases
LALA0_S14e00298g	highly similar to uniprot|P22203 Saccharomyces cerevisiae YOR332W VMA4 Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
LALA0_S14e00320g	similar to uniprot|Q01926 Saccharomyces cerevisiae YOR334W MRS2 Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns
LALA0_S14e00342g	weakly similar to uniprot|P39732 Saccharomyces cerevisiae YAL031C GIP4 Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate
LALA0_S14e00364g	similar to uniprot|P28004 Saccharomyces cerevisiae YAL032C PRP45 Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene
LALA0_S14e00386g	similar to uniprot|P28005 Saccharomyces cerevisiae YAL033W POP5 Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
LALA0_S14e00408g	highly similar to uniprot|P40825 Saccharomyces cerevisiae YOR335C ALA1 Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
LALA0_S14e00430g	similar to uniprot|P22023 Saccharomyces cerevisiae YOR336W KRE5 Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
LALA0_S14e00452g	similar to uniprot|P47988 Saccharomyces cerevisiae YOR337W TEA1 Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
LALA0_S14e00474g	weakly similar to uniprot|Q01090 Lachancea waltii pKW1_04 hypothetical protein
LALA0_S14e00496g	hypothetical protein
LALA0_S14e00518g	similar to uniprot|O13515 Saccharomyces cerevisiae YAL034C (ohnolog of YOR338W) FUN19 Non-essential protein of unknown function; expression induced in response to heat stress
LALA0_S14e00540g	similar to uniprot|P52492 Saccharomyces cerevisiae YOR339C UBC11 Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
LALA0_S14e00562g	similar to uniprot|P39731 Saccharomyces cerevisiae YAL034W-A MTW1 Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
LALA0_S14e00584g	similar to uniprot|P46669 Saccharomyces cerevisiae YOR340C RPA43 RNA polymerase I subunit A43
LALA0_S14e00606g	highly similar to uniprot|G8BZN7 Tetrapisispora phaffii TPHA0K02350 hypothetical protein
LALA0_S14e00628g	highly similar to uniprot|P10964 Saccharomyces cerevisiae YOR341W RPA190 RNA polymerase I largest subunit A190
LALA0_S14e00650g	highly similar to uniprot|P39730 Saccharomyces cerevisiae YAL035W FUN12 GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
LALA0_S14e00672g	weakly similar to Lachancea thermotolerans KLTH0G19426g hypothetical protein
LALA0_S14e00694g	highly similar to uniprot|P39729 Saccharomyces cerevisiae YAL036C RBG1 Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid
LALA0_S14e00716g	weakly similar to uniprot|P39728 Saccharomyces cerevisiae YAL037W (ohnolog of YOR342C) Putative protein of unknown function
LALA0_S14e00738g	weakly similar to uniprot|P33122 Saccharomyces cerevisiae YOR344C TYE7 Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
LALA0_S14e00760g	similar to uniprot|P12689 Saccharomyces cerevisiae YOR346W REV1 Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p
LALA0_S14e00782g	highly similar to uniprot|P00549 Saccharomyces cerevisiae YAL038W (ohnolog of YOR347C) CDC19 Pyruvatekinase, functions as a homotetramer in glycolysis toconvert phosphoenolpyruvate to pyruvate, the input foraerobic (TCA cycle) or anaerobic (glucose fermentation)respiration
LALA0_S14e00804g	weakly similar to uniprot|P40987 Saccharomyces cerevisiae YOR349W CIN1 Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
LALA0_S14e00826g	weakly similar to uniprot|P24720 Saccharomyces cerevisiae YOR350C MNE1 Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA
LALA0_S14e00848g	similar to uniprot|P24719 Saccharomyces cerevisiae YOR351C MEK1 Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
LALA0_S14e00870g	similar to uniprot|Q08816 Saccharomyces cerevisiae YOR352W Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
LALA0_S14e00892g	similar to uniprot|Q08817 Saccharomyces cerevisiae YOR353C SOG2 Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
LALA0_S14e00914g	similar to uniprot|P06182 Saccharomyces cerevisiae YAL039C CYC3 Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
LALA0_S14e00936g	weakly similar to uniprot|Q08818 Saccharomyces cerevisiae YOR354C MSC6 Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S14e00980g	weakly similar to uniprot|P13365 Saccharomyces cerevisiae YAL040C CLN3 G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
LALA0_S14e01002g	similar to uniprot|C5DFX2 Lachancea thermotolerans KLTH0D00660g hypothetical protein
LALA0_S14e01024g	similar to uniprot|P41913 Saccharomyces cerevisiae YOR355W GDS1 Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S14e01046g	similar to uniprot|Q08822 Saccharomyces cerevisiae YOR356W CIR2 Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response
LALA0_S14e01068g	similar to uniprot|P11433 Saccharomyces cerevisiae YAL041W CDC24 Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing
LALA0_S14e01090g	highly similar to uniprot|P39727 Saccharomyces cerevisiae YAL042W ERV46 Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
LALA0_S14e01112g	highly similar to uniprot|Q08826 Saccharomyces cerevisiae YOR357C SNX3 Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
LALA0_S14e01134g	some similarities with uniprot|Q02516 Saccharomyces cerevisiae YOR358W HAP5 Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
LALA0_S14e01156g	similar to uniprot|Q01329 Saccharomyces cerevisiae YAL043C PTA1 Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
LALA0_S14e01178g	similar to uniprot|Q08831 Saccharomyces cerevisiae YOR359W VTS1 Post-transcriptional gene regulator, flap-structured DNA-binding and RNA-binding protein; shows genetic interactions with Vti1p, a v-SNARE involved in cis-Golgi membrane traffic; stimulates Dna2p endonuclease activity; contains a SAM domain
LALA0_S14e01200g	similar to uniprot|P06776 Saccharomyces cerevisiae YOR360C PDE2 High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
LALA0_S14e01222g	similar to uniprot|P39726 Saccharomyces cerevisiae YAL044C GCV3 H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF
LALA0_S14e01244g	similar to uniprot|Q3E793 Saccharomyces cerevisiae YAL044W-A Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
LALA0_S14e01266g	similar to uniprot|P39724 Saccharomyces cerevisiae YAL046C AIM1 Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss
LALA0_S14e01288g	similar to uniprot|P06103 Saccharomyces cerevisiae YOR361C PRT1 eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
LALA0_S14e01310g	weakly similar to uniprot|P39723 Saccharomyces cerevisiae YAL047C SPC72 Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
LALA0_S14e01332g	highly similar to uniprot|P21242 Saccharomyces cerevisiae YOR362C PRE10 Alpha 7 subunit of the 20S proteasome
LALA0_S14e01354g	highly similar to uniprot|P39722 Saccharomyces cerevisiae YAL048C GEM1 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death
LALA0_S14e01376g	weakly similar to uniprot|P39720 Saccharomyces cerevisiae YAL051W (ohnolog of YOR363C) OAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
LALA0_S14e01398g	similar to uniprot|P39719 Saccharomyces cerevisiae YAL053W (ohnolog of YOR365C) FLC2 Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
LALA0_S14e01420g	similar to uniprot|Q08873 Saccharomyces cerevisiae YOR367W SCP1 Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
LALA0_S14e01442g	weakly similar to uniprot|P39718 Saccharomyces cerevisiae YAL055W PEX22 Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation
LALA0_S14e01464g	similar to uniprot|P48581 Saccharomyces cerevisiae YOR368W RAD17 Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
LALA0_S14e01486g	highly similar to uniprot|P48589 Saccharomyces cerevisiae YOR369C RPS12 Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
LALA0_S14e01508g	highly similar to uniprot|P32864 Saccharomyces cerevisiae YOR370C MRS6 Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene
LALA0_S14e01530g	weakly similar to uniprot|P39717 Saccharomyces cerevisiae YAL056W (ohnolog of YOR371C) GPB2 Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p
LALA0_S14e01552g	weakly similar to uniprot|Q08887 Saccharomyces cerevisiae YOR372C NDD1 Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes
LALA0_S14e01574g	weakly similar to uniprot|P32336 Saccharomyces cerevisiae YOR373W NUD1 Component of the spindle pole body outer plaque, required for exit from mitosis
LALA0_S14e01596g	highly similar to uniprot|P46367 Saccharomyces cerevisiae YOR374W ALD4 Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
LALA0_S14e01618g	similar to uniprot|G0RUS3 Hypocrea jecorina TRIREDRAFT_69077 hypothetical protein
LALA0_S14e01640g	similar to uniprot|P39715 Saccharomyces cerevisiae YAL059W ECM1 Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm
LALA0_S14e01662g	highly similar to uniprot|P39708 Saccharomyces cerevisiae YAL062W (ohnolog of YOR375C) GDH3 NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
LALA0_S14e01684g	weakly similar to uniprot|P38195 Saccharomyces cerevisiae YBL043W (ohnolog of YJR115W) ECM13 Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
LALA0_S14e01706g	similar to uniprot|P38716 Saccharomyces cerevisiae YHR112C Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway
LALA0_S14e01728g	weakly similar to uniprot|P53389 Saccharomyces cerevisiae YNR055C HOL1 Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake
LALA0_S14e01750g	weakly similar to uniprot|Q12151 Saccharomyces cerevisiae YDR213W (ohnolog of YLR228C) UPC2 Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion
LALA0_S14e01772g	similar to uniprot|C5DJ05 Lachancea thermotolerans KLTH0E16610g hypothetical protein
LALA0_S14e01794g	similar to uniprot|Q02895 Saccharomyces cerevisiae YPL088W Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
LALA0_S14e01816g	similar to uniprot|P38358 Saccharomyces cerevisiae YBR293W VBA2 Permease of basic amino acids in the vacuolar membrane
LALA0_S14e01838g	highly similar to uniprot|C5DCQ9 Lachancea thermotolerans KLTH0B05082g hypothetical protein
LALA0_S14e01860g	similar to uniprot|P40586 Saccharomyces cerevisiae YIR042C Putative protein of unknown function; YIR042C is a non-essential gene
LALA0_S14e01882g	similar to uniprot|Q12358 Saccharomyces cerevisiae YLL057C JLP1 Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation
LALA0_S14e01904g	weakly similar to uniprot|Q07629 Saccharomyces cerevisiae YDL218W Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin
LALA0_S14e01926g	some similarities with uniprot|P40447 Saccharomyces cerevisiae YIL164C NIT1 Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
LALA0_S14e01948g	similar to uniprot|P53750 Saccharomyces cerevisiae YNR064C Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides
LALA0_S15e00100g	weakly similar to uniprot|Q06133 Saccharomyces cerevisiae YLR337C VRP1 Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
LALA0_S15e00122g	similar to uniprot|P28737 Saccharomyces cerevisiae YGR028W MSP1 Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
LALA0_S15e00144g	similar to uniprot|Q06132 Saccharomyces cerevisiae YLR336C SGD1 Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
LALA0_S15e00166g	similar to uniprot|P32499 Saccharomyces cerevisiae YLR335W NUP2 Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
LALA0_S15e00210g	highly similar to uniprot|Q3E792 Saccharomyces cerevisiae YGR027C (ohnolog of YLR333C) RPS25A Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
LALA0_S15e00232g	similar to uniprot|P53217 Saccharomyces cerevisiae YGR026W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
LALA0_S15e00254g	weakly similar to uniprot|P43600 Saccharomyces cerevisiae YFR020W Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
LALA0_S15e00276g	some similarities with uniprot|Q12491 Saccharomyces cerevisiae YBL100W-B TY2B-B Transposon Ty2-B Gag-Pol polyprotein
LALA0_S15e00298g	hypothetical protein
LALA0_S15e00320g	similar to uniprot|P32564 Saccharomyces cerevisiae YGR049W (ohnolog of YLR356W) SCM4 Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis
LALA0_S15e00342g	weakly similar to uniprot|P53233 Saccharomyces cerevisiae YGR052W FMP48 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
LALA0_S15e00364g	weakly similar to uniprot|P53234 Saccharomyces cerevisiae YGR053C Putative protein of unknown function
LALA0_S15e00386g	similar to uniprot|P53235 Saccharomyces cerevisiae YGR054W Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A
LALA0_S15e00408g	similar to uniprot|C5DNR7 Lachancea thermotolerans KLTH0G19272g hypothetical protein
LALA0_S15e00430g	similar to uniprot|P43568 Saccharomyces cerevisiae YFL029C CAK1 Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases
LALA0_S15e00452g	similar to uniprot|P32353 Saccharomyces cerevisiae YLR056W ERG3 C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
LALA0_S15e00474g	similar to uniprot|P43569 Saccharomyces cerevisiae YFL028C CAF16 Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
LALA0_S15e00496g	similar to uniprot|P38915 Saccharomyces cerevisiae YLR055C SPT8 Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
LALA0_S15e00518g	weakly similar to uniprot|P43570 Saccharomyces cerevisiae YFL027C GYP8 GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
LALA0_S15e00540g	some similarities with uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
LALA0_S15e00562g	weakly similar to uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
LALA0_S15e00584g	weakly similar to uniprot|P23250 Saccharomyces cerevisiae YIL119C RPI1 Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
LALA0_S15e00606g	weakly similar to uniprot|Q7LGY1 Saccharomyces cerevisiae YLR057W Putative protein of unknown function; YLR050W is not an essential gene
LALA0_S15e00628g	highly similar to uniprot|P37291 Saccharomyces cerevisiae YLR058C SHM2 Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
LALA0_S15e00650g	similar to uniprot|P43567 Saccharomyces cerevisiae YFL030W AGX1 Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
LALA0_S15e00672g	weakly similar to uniprot|P25491 Saccharomyces cerevisiae YNL064C YDJ1 Type I HSP40 co-chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
LALA0_S15e00694g	weakly similar to uniprot|P03870 Saccharomyces cerevisiae R0010W FLP1 Site-specific recombinase Flp
LALA0_S15e00716g	weakly similar to uniprot|P41546 Saccharomyces cerevisiae YFL031W HAC1 Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis
LALA0_S15e00738g	weakly similar to uniprot|P54964 Saccharomyces cerevisiae YLR059C REX2 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease
LALA0_S15e00760g	similar to uniprot|P43565 Saccharomyces cerevisiae YFL033C RIM15 Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
LALA0_S15e00782g	highly similar to uniprot|P15624 Saccharomyces cerevisiae YLR060W FRS1 Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
LALA0_S15e00804g	similar to uniprot|P43564 Saccharomyces cerevisiae YFL034W Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
LALA0_S15e00826g	highly similar to uniprot|P56628 Saccharomyces cerevisiae YFL034C-A (ohnolog of YLR061W) RPL22B Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein
LALA0_S15e00848g	similar to uniprot|Q12291 Saccharomyces cerevisiae YLR063W Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
LALA0_S15e00870g	highly similar to uniprot|P43563 Saccharomyces cerevisiae YFL034C-B MOB2 Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
LALA0_S15e00892g	similar to uniprot|P13433 Saccharomyces cerevisiae YFL036W RPO41 Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
LALA0_S15e00914g	highly similar to uniprot|P02557 Saccharomyces cerevisiae YFL037W TUB2 Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules
LALA0_S15e00936g	highly similar to uniprot|P01123 Saccharomyces cerevisiae YFL038C YPT1 Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
LALA0_S15e00958g	similar to uniprot|Q6Q5C1 Saccharomyces cerevisiae YLR065C Putative protein of unknown function; YLR065C is not an essential gene
LALA0_S15e00980g	highly similar to uniprot|P02579 Saccharomyces cerevisiae YFL039C ACT1 Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
LALA0_S15e01002g	similar to uniprot|P43562 Saccharomyces cerevisiae YFL040W Putative transporter, member of the sugar porter family; YFL040W is not an essential gene
LALA0_S15e01024g	similar to uniprot|Q12133 Saccharomyces cerevisiae YLR066W SPC3 Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
LALA0_S15e01046g	similar to uniprot|P32522 Saccharomyces cerevisiae YLR067C PET309 Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)
LALA0_S15e01068g	similar to uniprot|Q12247 Saccharomyces cerevisiae YLR068W FYV7 Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
LALA0_S15e01090g	highly similar to uniprot|P25039 Saccharomyces cerevisiae YLR069C MEF1 Mitochondrial elongation factor involved in translational elongation
LALA0_S15e01112g	similar to uniprot|P43561 Saccharomyces cerevisiae YFL041W FET5 Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
LALA0_S15e01134g	similar to uniprot|P35497 Saccharomyces cerevisiae YJR159W SOR1 Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose
LALA0_S15e01156g	similar to uniprot|P19263 Saccharomyces cerevisiae YLR071C RGR1 Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation
LALA0_S15e01178g	some similarities with uniprot|P43560 Saccharomyces cerevisiae YFL042C (ohnolog of YLR072W) Putative protein of unknown function; YFL042C is not an essential gene
LALA0_S15e01200g	similar to uniprot|Q08003 Saccharomyces cerevisiae YLR073C RFU1 Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes
LALA0_S15e01222g	similar to uniprot|P43558 Saccharomyces cerevisiae YFL044C OTU1 Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family
LALA0_S15e01244g	similar to uniprot|Q08004 Saccharomyces cerevisiae YLR074C BUD20 Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
LALA0_S15e01266g	highly similar to uniprot|P41805 Saccharomyces cerevisiae YLR075W RPL10 Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
LALA0_S15e01288g	highly similar to uniprot|P07283 Saccharomyces cerevisiae YFL045C SEC53 Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
LALA0_S15e01310g	similar to uniprot|P43557 Saccharomyces cerevisiae YFL046W FMP32 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S15e01332g	similar to uniprot|Q7LI62 Saccharomyces cerevisiae YLR077W FMP25 Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria
LALA0_S15e01354g	similar to uniprot|P25385 Saccharomyces cerevisiae YLR078C BOS1 v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
LALA0_S15e01376g	weakly similar to uniprot|P38634 Saccharomyces cerevisiae YLR079W SIC1 Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
LALA0_S15e01398g	similar to uniprot|P43556 Saccharomyces cerevisiae YFL047W RGD2 GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p
LALA0_S15e01420g	similar to GI|495487560 Rhodanobacter sp. 2,4-dichlorophenol 6-monooxygenase
LALA0_S15e01442g	similar to uniprot|P43555 Saccharomyces cerevisiae YFL048C (ohnolog of YLR080W) EMP47 Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
LALA0_S15e01464g	weakly similar to uniprot|P43554 Saccharomyces cerevisiae YFL049W SWP82 Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p
LALA0_S15e01486g	similar to Lachancea thermotolerans KLTH0F00110g hypothetical protein
LALA0_S15e01508g	highly similar to uniprot|P04076 Saccharomyces cerevisiae YHR018C ARG4 Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
LALA0_S15e01530g	similar to uniprot|P34251 Saccharomyces cerevisiae YKL107W Putative protein of unknown function; proposed to be a palmitoylated membrane protein
LALA0_S15e01552g	similar to uniprot|P24031 Saccharomyces cerevisiae YBR092C PHO3 Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
LALA0_S15e01574g	similar to uniprot|Q12177 Saccharomyces cerevisiae YLL056C Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
LALA0_S15e01596g	highly similar to uniprot|C5E3F9 Lachancea thermotolerans KLTH0H13090g hypothetical protein
LALA0_S15e01618g	similar to uniprot|Q12177 Saccharomyces cerevisiae YLL056C Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
LALA0_S15e01640g	similar to uniprot|Q12177 Saccharomyces cerevisiae YLL056C Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
LALA0_S15e01662g	similar to uniprot|Q12177 Saccharomyces cerevisiae YLL056C Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin
LALA0_S15e01684g	weakly similar to uniprot|P53745 Saccharomyces cerevisiae YNR059W MNT4 Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation
LALA0_S15e01750g	highly similar to uniprot|P46969 Saccharomyces cerevisiae YJL121C RPE1 D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
LALA0_S15e01772g	similar to uniprot|P47019 Saccharomyces cerevisiae YJL122W ALB1 Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
LALA0_S15e01794g	similar to uniprot|P47018 Saccharomyces cerevisiae YJL123C MTC1 Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1
LALA0_S15e01816g	similar to uniprot|P36141 Saccharomyces cerevisiae YKR049C FMP46 Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S15e01838g	similar to uniprot|P47017 Saccharomyces cerevisiae YJL124C LSM1 Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
LALA0_S15e01860g	similar to uniprot|P46959 Saccharomyces cerevisiae YJL125C GCD14 Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
LALA0_S15e01882g	similar to uniprot|P47016 Saccharomyces cerevisiae YJL126W NIT2 Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
LALA0_S16e00100g	similar to uniprot|P00431 Saccharomyces cerevisiae YKR066C CCP1 Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
LALA0_S16e00122g	highly similar to uniprot|P42884 Saccharomyces cerevisiae YNL331C AAD14 Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
LALA0_S16e00144g	highly similar to uniprot|P10127 Saccharomyces cerevisiae YGL256W ADH4 Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
LALA0_S16e00166g	similar to uniprot|Q08579 Saccharomyces cerevisiae YOR192C THI72 Transporter of thiamine or related compound; shares sequence similarity with Thi7p
LALA0_S16e00188g	similar to uniprot|C5DC55 Lachancea thermotolerans KLTH0B00110g putative transmembrane transporter
LALA0_S16e00210g	similar to uniprot|Q05131 Saccharomyces cerevisiae YMR034C Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
LALA0_S16e00232g	weakly similar to uniprot|P26188 Saccharomyces cerevisiae YDL200C MGT1 DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
LALA0_S16e00254g	similar to uniprot|P53744 Saccharomyces cerevisiae YNR056C BIO5 Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
LALA0_S16e00276g	similar to uniprot|P32843 Saccharomyces cerevisiae YMR302C YME2 Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
LALA0_S16e00298g	similar to uniprot|P50101 Saccharomyces cerevisiae YMR304W UBP15 Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p
LALA0_S16e00320g	similar to uniprot|P53332 Saccharomyces cerevisiae YGR277C CAB4 Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved
LALA0_S16e00342g	similar to uniprot|P53333 Saccharomyces cerevisiae YGR278W CWC22 Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
LALA0_S16e00364g	similar to uniprot|P53334 Saccharomyces cerevisiae YGR279C (ohnolog of YMR305C) SCW4 Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
LALA0_S16e00386g	highly similar to uniprot|Q04952 Saccharomyces cerevisiae YMR306W FKS3 Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S16e00408g	similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery
LALA0_S16e00430g	similar to uniprot|P22146 Saccharomyces cerevisiae YMR307W GAS1 Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery
LALA0_S16e00452g	similar to uniprot|P53335 Saccharomyces cerevisiae YGR280C PXR1 Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
LALA0_S16e00474g	highly similar to uniprot|P32337 Saccharomyces cerevisiae YMR308C PSE1 Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
LALA0_S16e00496g	weakly similar to uniprot|P38114 Saccharomyces cerevisiae YBR150C (ohnolog of YOL089C) TBS1 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S16e00518g	similar to uniprot|P53049 Saccharomyces cerevisiae YGR281W YOR1 Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)
LALA0_S16e00540g	similar to uniprot|Q08417 Saccharomyces cerevisiae YOR049C RSB1 Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
LALA0_S16e00562g	some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
LALA0_S17e00100g	some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
LALA0_S17e00122g	hypothetical protein
LALA0_S17e00144g	weakly similar to uniprot|P36086 Saccharomyces cerevisiae YKL071W Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S17e00166g	weakly similar to uniprot|P24813 Saccharomyces cerevisiae YDR423C (ohnolog of YML007W) CAD1 AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA
LALA0_S17e00188g	weakly similar to uniprot|P32578 Saccharomyces cerevisiae YDR422C SIP1 Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions
LALA0_S17e00210g	weakly similar to uniprot|Q04233 Saccharomyces cerevisiae YML006C GIS4 CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
LALA0_S17e00232g	weakly similar to uniprot|P41809 Saccharomyces cerevisiae YDR420W HKR1 Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection
LALA0_S17e00254g	similar to uniprot|P32317 Saccharomyces cerevisiae YEL052W AFG1 Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
LALA0_S17e00276g	similar to uniprot|Q02197 Saccharomyces cerevisiae YEL053C MAK10 Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
LALA0_S17e00298g	highly similar to uniprot|P17079 Saccharomyces cerevisiae YEL054C (ohnolog of YDR418W) RPL12A Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
LALA0_S17e00320g	some similarities with uniprot|P31787 Saccharomyces cerevisiae YGR037C ACB1 Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion
LALA0_S17e00342g	similar to uniprot|Q04049 Saccharomyces cerevisiae YDR419W RAD30 DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; mutations in human pol eta are responsible for XPV
LALA0_S17e00386g	similar to uniprot|Q03759 Saccharomyces cerevisiae YML108W Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene
LALA0_S17e00408g	weakly similar to uniprot|P50111 Saccharomyces cerevisiae YMR273C (ohnolog of YML109W) ZDS1 Protein with a role in regulating Swe1p-dependent polarized growth; interacts with silencing proteins at the telomere; has a role in Bcy1p localization; implicated in mRNA nuclear export; involved in mitotic exit through Cdc14p regulation
LALA0_S17e00430g	similar to uniprot|Q03530 Saccharomyces cerevisiae YMR274C RCE1 Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone
LALA0_S17e00474g	highly similar to uniprot|P49017 Saccharomyces cerevisiae YML110C COQ5 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
LALA0_S17e00496g	similar to uniprot|P48524 Saccharomyces cerevisiae YMR275C (ohnolog of YML111W) BUL1 Ubiquitin-bindingcomponent of the Rsp5p E3-ubiquitin ligase complex,functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting ofamino acid permeases
LALA0_S17e00518g	similar to uniprot|P46963 Saccharomyces cerevisiae YML112W CTK3 Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity
LALA0_S17e00540g	weakly similar to uniprot|P13483 Saccharomyces cerevisiae YML113W DAT1 DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
LALA0_S18e00100g	some similarities with uniprot|P38894 Saccharomyces cerevisiae YHR211W FLO5 Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
LALA0_S18e00122g	highly similar to uniprot|P38891 Saccharomyces cerevisiae YHR208W (ohnolog of YJR148W) BAT1 Mitochondrial branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
LALA0_S18e00144g	similar to uniprot|P40099 Saccharomyces cerevisiae YER183C FAU1 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
LALA0_S18e00166g	similar to uniprot|P40098 Saccharomyces cerevisiae YER182W FMP10 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
LALA0_S18e00188g	similar to uniprot|P38890 Saccharomyces cerevisiae YHR207C SET5 Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus
LALA0_S18e00210g	similar to uniprot|P38889 Saccharomyces cerevisiae YHR206W (ohnolog of YJR147W) SKN7 Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation
LALA0_S18e00232g	similar to uniprot|P11792 Saccharomyces cerevisiae YHR205W SCH9 Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB
LALA0_S18e00254g	highly similar to uniprot|P0CX36 Saccharomyces cerevisiae YHR203C (ohnolog of YJR145C) RPS4B Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
LALA0_S18e00276g	similar to uniprot|P38887 Saccharomyces cerevisiae YHR202W Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
LALA0_S18e00298g	similar to uniprot|P32787 Saccharomyces cerevisiae YJR144W MGM101 Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
LALA0_S18e00320g	similar to uniprot|P46971 Saccharomyces cerevisiae YJR143C PMT4 Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals
LALA0_S18e00342g	similar to uniprot|P47173 Saccharomyces cerevisiae YJR142W Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition
LALA0_S18e00364g	similar to uniprot|P38698 Saccharomyces cerevisiae YHR201C PPX1 Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
LALA0_S18e00386g	similar to uniprot|P47172 Saccharomyces cerevisiae YJR141W Essential protein of unknown function
LALA0_S18e00408g	similar to uniprot|P47171 Saccharomyces cerevisiae YJR140C HIR3 Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein
LALA0_S18e00430g	highly similar to uniprot|P31116 Saccharomyces cerevisiae YJR139C HOM6 Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
LALA0_S18e00452g	similar to uniprot|P47170 Saccharomyces cerevisiae YJR138W IML1 Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal CDC48-like domain and a C-terminal DEP domain; central region is readily accessible to proteases
LALA0_S18e00474g	highly similar to uniprot|P38886 Saccharomyces cerevisiae YHR200W RPN10 Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
LALA0_S19e00100g	some similarities with uniprot|C5DHK8 Lachancea thermotolerans KLTH0E05148g hypothetical protein
LALA0_S19e00122g	similar to uniprot|P36172 Saccharomyces cerevisiae YKR105C Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny
LALA0_S19e00144g	similar to uniprot|P25379 Saccharomyces cerevisiae YCL064C CHA1 Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
LALA0_S19e00166g	some similarities with uniprot|P40896 Saccharomyces cerevisiae YJL213W Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
LALA0_S19e00188g	weakly similar to uniprot|P15365 Saccharomyces cerevisiae YJR152W DAL5 Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression
LALA0_S19e00210g	highly similar to uniprot|P42884 Saccharomyces cerevisiae YNL331C AAD14 Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
LALA0_S19e00232g	highly similar to uniprot|P10127 Saccharomyces cerevisiae YGL256W ADH4 Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
LALA0_S19e00254g	similar to uniprot|A8WRF6 Caenorhabditis briggsae CBG01854 hypothetical protein
LALA0_S19e00276g	similar to uniprot|Q05131 Saccharomyces cerevisiae YMR034C Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
LALA0_S19e00298g	similar to uniprot|P26188 Saccharomyces cerevisiae YDL200C MGT1 DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage
LALA0_S19e00320g	some similarities with uniprot|A8WRF6 Caenorhabditis briggsae CBG01854 hypothetical protein
LALA0_S20e00100g	some similarities with uniprot|P32768 Saccharomyces cerevisiae YAR050W FLO1 Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
LALA0_S20e00122g	similar to uniprot|P41816 Saccharomyces cerevisiae YPL171C OYE3 Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death
LALA0_S20e00144g	highly similar to uniprot|P25087 Saccharomyces cerevisiae YML008C ERG6 Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane
LALA0_S20e00166g	weakly similar to uniprot|P25346 Saccharomyces cerevisiae YCR098C GIT1 Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
LALA0_S20e00188g	some similarities with uniprot|P53086 Saccharomyces cerevisiae YGL216W KIP3 Kinesin-related motor protein involved in mitotic spindle positioning
LALA0_S20e00210g	highly similar to uniprot|Q02647 Saccharomyces cerevisiae YDR424C DYN2 Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex
LALA0_S20e00232g	similar to uniprot|Q04053 Saccharomyces cerevisiae YDR425W SNX41 Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p
LALA0_S20e00254g	highly similar to uniprot|Q04062 Saccharomyces cerevisiae YDR427W RPN9 Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects
LALA0_S20e00276g	similar to uniprot|Q04066 Saccharomyces cerevisiae YDR428C BNA7 Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine
LALA0_S20e00298g	similar to uniprot|Q04067 Saccharomyces cerevisiae YDR429C TIF35 eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
LALA0_S21e00100g	some similarities with uniprot|P38735 Saccharomyces cerevisiae YHL035C (ohnolog of YLL048C) VMR1 Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions
LALA0_S21e00122g	some similarities with uniprot|P39720 Saccharomyces cerevisiae YAL051W (ohnolog of YOR363C) OAF1 Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis
LALA0_S21e00144g	weakly similar to uniprot|P43561 Saccharomyces cerevisiae YFL041W FET5 Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
LALA0_S21e00166g	similar to Lachancea thermotolerans KLTH0B10318g hypothetical protein
LALA0_S21e00188g	similar to uniprot|P38732 Saccharomyces cerevisiae YHL039W EFM1 Probable lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
LALA0_S21e00210g	highly similar to uniprot|Q03048 Saccharomyces cerevisiae YLL050C COF1 Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
LALA0_S21e00232g	weakly similar to uniprot|Q07887 Saccharomyces cerevisiae YLL049W LDB18 Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24
LALA0_S21e00254g	weakly similar to uniprot|P03874 Saccharomyces cerevisiae YHL038C CBP2 Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
LALA0_S21e00276g	similar to uniprot|P38734 Saccharomyces cerevisiae YHL036W MUP3 Low affinity methionine permease, similar to Mup1p
LALA0_S21e00298g	some similarities with uniprot|P38735 Saccharomyces cerevisiae YHL035C (ohnolog of YLL048C) VMR1 Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions
LALA0_S22e00100g	putative transposase of the Rover hAT-like DNA transposon, degenerate;putative transposase of the Rover hAT-like DNA transposon, degenerate
LALA0_S22e00122g	weakly similar to uniprot|P40475 Saccharomyces cerevisiae YIL120W (ohnolog of YNL065W) QDR1 Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban
LALA0_S22e00144g	similar to uniprot|P0CH64 Saccharomyces cerevisiae YNL335W DDI3 Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants
LALA0_S22e00166g	similar to uniprot|P33335 Saccharomyces cerevisiae YPR198W SGE1 Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
LALA0_S22e00188g	weakly similar to uniprot|P40024 Saccharomyces cerevisiae YER036C ARB1 ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
LALA0_S22e00210g	similar to uniprot|Q12198 Saccharomyces cerevisiae YLL058W Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
LALA0_S22e00232g	some similarities with uniprot|C5DG35 Lachancea thermotolerans KLTH0D02090g hypothetical protein
LALA0_S23e00100g	similar to uniprot|P32804 Saccharomyces cerevisiae YGL255W ZRT1 High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
LALA0_S23e00122g	similar to uniprot|P32837 Saccharomyces cerevisiae YDL210W UGA4 Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
LALA0_S23e00144g	similar to uniprot|P38735 Saccharomyces cerevisiae YHL035C (ohnolog of YLL048C) VMR1 Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions
LALA0_S24e00100g	similar to uniprot|P38087 Saccharomyces cerevisiae YBR104W (ohnolog of YPR058W) YMC2 Mitochondrial protein,putative inner membrane transporter with a role in oleatemetabolism and glutamate biosynthesis; member of themitochondrial carrier (MCF) family; has similarity withYmc1p